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Diagnosis of a Familial Psittacosis Outbreak with Clinical Analysis and Metagenomic Next-Generation Sequencing Under COVID-19: A Case Series Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-18 Jiaru Wang, Peiyao Jia, Dong Zhang, Ying Zhao, Xin Sui, Zhengyu Jin, Wei Song
Purpose: To explore the clinical characteristics, diagnosis, and treatment of family outbreak of psittacosis and to improve the success rate of treatment. Patients and Methods: The clinical characteristics, diagnosis, treatment, and outcome of family outbreak of psittacosis, which consists three patients, diagnosed by clinical analysis and metagenomic next-generation sequencing (mNGS) in our hospital
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Hepatic Involvement in Acquired Immunodeficiency Syndrome-Associated Kaposi’s Sarcoma: A Descriptive Analysis on CT, MRI, and Ultrasound Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-18 Chun-Shuang Guan, Jing Yu, Yan-Ni Du, Xin-Gang Zhou, Zi-Xin Zhang, Hui Chen, Yu-Xue Xing, Ru-Ming Xie, Zhi-Bin Lv
Purpose: To retrospectively analyse the different imaging manifestations of acquired immunodeficiency syndrome-associated hepatic Kaposi’s sarcoma (AIDS-HKS) on CT, MRI, and Ultrasound. Patients and Methods: Eight patients were enrolled in the study. Laboratory tests of liver function were performed. The CT, MRI, and Ultrasound manifestations were reviewed by two radiologists and two sonographers,
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Reliability of Droplet Digital PCR Alone and in Combination with Interleukin-6 and Procalcitonin for Prognosis of Bloodstream Infection Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-15 Sheng Yin, YingRui Lin, Bingqi Wang, Yizhi Peng, Zeyou Wang, Xiaolin Zhu, Hao Liang, Xianping Li, Min Wang
Purpose: Bloodstream infection(BSI) is linked with high mortality, underscoring the significance of prompt etiological diagnosis for timely and precise treatment. This study aims to investigate the diagnostic value of droplet digital polymerase chain reaction(ddPCR) in combination with conventional inflammatory markers [interleukin-6(IL-6) and procalcitonin(PCT)] concerning disease progression and
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A Cross-Sectional Study on Awareness of Tuberculosis Control Among Post-Treatment Tuberculosis Patients in a City in China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-15 Rui Jing, Hui Dong, Kun Huang, Zhong Liu, Ran Xue, Yiran Dong, Mei Jiao, Na Li, Yumei Guo, Yun Liu, Wenqian Zhang, Hongyun Sun
Purpose: This study aimed to investigate awareness of tuberculosis control among post-treatment tuberculosis patients, in order to provide a basis for future preventive and control work in this population. Patients and Methods: A cross-sectional descriptive study was conducted on post-treatment patients with tuberculosis in seven districts of Jinan City between July 2021 and December 2022. A face-to-face
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Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-14 Radostina Alexandrova, Ilia Tsachev, Plamen Kirov, Abedulkadir Abudalleh, Hristo Hristov, Tanya Zhivkova, Lora Dyakova, Magdalena Baymakova
Abstract: Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus that belongs to Hepeviridae family. HEV is the most common cause of acute viral hepatitis worldwide. According to the World Health Organization (WHO), there are estimated 20 million HEV infections worldwide every year, leading to estimated 3.3 million symptomatic cases of HEV infection. The WHO estimates that HEV infection
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Analysis of the Risk Factors for Plastic Bronchitis in Children with Severe Adenovirus Pneumonia: A Retrospective Study Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-14 Xue-hua Xu, Jie-rong Cai, Hui-feng Fan, Ting-ting Shi, Di-yuan Yang, Li Huang, Dong-wei Zhang, Gen Lu
Purpose: Plastic bronchitis (PB), a rare complication of respiratory infection characterized by the formation of casts in the tracheobronchial tree, can lead to airway obstruction and severe condition. Adenovirus is one of the common pathogens of PB caused by infection. This study aimed to evaluate the clinical features and risk factors for PB in children with severe adenovirus pneumonia. Methods:
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Sepsis and Hepatapostema Secondary to Chromobacterium Violaceum Infection on Lower Limb Skin: A Case Report Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-14 Kun Li, Dongsheng Han, Ahmad Alhaskawi, Tingting Liu, Xiaojuan Wang, Wu Yang, Hui Lu, Xueling Fang
Background: Chromobacterium violaceum (C. violaceum) is a Gram-negative bacterium capable of causing severe infections in both humans and specific animals. Despite its infrequency, C. violaceum infections exhibit a notably high mortality rate. The timely and precise detection of this pathogen stands as a critical factor in achieving effective diagnosis and treatment. Traditional diagnostic approaches
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Effects of Maternal Health During Pregnancy and Child Immunization on Mother-to-Child Transmission of Hepatitis B Virus: A Multicentre, Large-Sample Study in Southeast China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-13 Xin-Xin Huang, Quan Lin, Yun Li, Li Li
Purpose: High hepatitis B infection rates in China are a major public health issue, and mother-to-child transmission (MTCT) is a significant risk factor. Patients and Methods: This study was conducted with a prospective multicentre design from January 2021 to December 2022 in 245 hospitals providing midwifery services in southeastern China. The participants were pregnant women who were positive for
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Development of a Risk Prediction Model for Infection After Kidney Transplantation Transmitted from Bacterial Contaminated Preservation Solution Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-13 Mingxing Guo, Chen Pan, Ying Zhao, Wanyi Xu, Ye Xu, Dandan Li, Yichen Zhu, Xiangli Cui
Background: The risk of transplant recipient infection is unknown when the preservation solution culture is positive. Methods: We developed a prediction model to evaluate the infection in kidney transplant recipients within microbial contaminated preservation solution. Univariate logistic regression was utilized to identify risk factors for infection. Both stepwise selection with Akaike information
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Antimicrobial Resistance and Molecular Characterization of Salmonella Rissen Isolated in China During 2008–2019 Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-12 Lili Wang, Lu Nie, Yue Liu, Liang Hu, Aiping Zhou, Dongjiang Wang, Xuebin Xu, Jian Guo
Background: This study aimed to provide epidemiological features of Salmonella enterica serovar Rissen, determine antimicrobial susceptibility, virulence gene profiles, and describe the potential association of S. Rissen from different sources in China. Methods: During 2008– 2019, a total of non-repetitive 228 S. Rissen isolates were collected from human, animals and environment in China. The antimicrobial
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Atypical Rickettsia japonica Infection Involving Critical Illness Diagnosed by Metagenomic Next-Generation Sequencing: A Case Report Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-12 Zheng Yang, Zhanli Shi, Kun Fang, Danhong Ren
Background: Rickettsia japonica infection is a rare disease, it is rare to report critical and severe case caused by this disease in Zhejiang Province, China. Patient Concerns: We report a patient who initially sought medical attention due to fever and developed coma and convulsions during treatment. The patient did not develop typical eschar and rash. Eventually, the patient needed to be treated in
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Rapid Identification of Carbapenemase-Producing Klebsiella Pneumoniae Using Headspace Solid-Phase Microextraction Combined with Gas Chromatography-Mass Spectrometry [Corrigendum] Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-11 Hong Luo, Yaping Hang, Hongying Zhu, Qiaoshi Zhong, Suqin Peng, Shumin Gu, Xueyao Fang, Longhua Hu
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Incidence and Risk Factors of Active Tuberculosis Among Hospitalized Patients with Latent Tuberculosis Infection in China: A Cohort Study Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-11 Ye Liu, Lifan Zhang, Yan Chen, Guiren Ruan, Yuchen Liu, Shi Chen, Lantian Xie, Fengying Wu, Xiaochun Shi, Xiaoqing Liu
Background: The population with latent tuberculosis infection (LTBI) represents a potential pool of patients with active tuberculosis (ATB). T-SPOT.TB is an important test tool for screening LTBI. Owing to the large population of LTBI patients in China, it is necessary to identify a high-risk group for LTBI and enlarge tuberculosis preventive treatment (TPT) to reduce the incidence of ATB. Methods:
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Emergence of SARS-CoV-2 with Dual-Drug Resistant Mutations During a Long-Term Infection in a Kidney Transplant Recipient [Corrigendum] Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-11 Yoko Tanino, Keisuke Nishioka, Chie Yamamoto, Yohei Watanabe, Tomo Daidoji, Masataka Kawamoto, Sayaka Uda, Shoko Kirito, Yuta Nakagawa, Yu Kasamatsu, Yoshiyuki Kawahara, Yuri Sakai, Shuji Nobori, Tohru Inaba, Bon Ota, Naohisa Fujita, Atsushi Hoshino, Yoko Nukui, Takaaki Nakaya
Corrigendum for the article Emergence of SARS-CoV-2 with Dual-Drug Resistant Mutations During a Long-Term Infection in a Kidney Transplant Recipient
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Knowledge, Perception, and Self-Confidence of Antibiotic Resistance, Appropriate Antibiotic Therapy, and Antibiotic Stewardship Among Undergraduate Pharmacy Students in Sudan Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-11 Omalhassan Amir Abdelkarim, Usman Abubakar, Mohamed A Hussain, Abd Elrahman Babiker Abadi, Ahmed Osman Mohamed, Wadah Osman, Asmaa E Sherif, Sara Altayep Ebrahim, Asmaa Hussein Ahmed, Marwa Omer Ahmed, Ahmed Ashour
Background: Adequate training in infectious diseases and antibiotic resistance is crucial for pharmacy students to participate in antibiotic stewardship programs and understand microbiology careers. Aim: The study was carried out to assess the knowledge and self-reported confidence in antibiotic resistance, antibiotic therapy, and antimicrobial stewardship (AMS) among final-year undergraduate pharmacy
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Birth Outcomes of Pregnant Women Infected with COVID-19 in Highland Areas of China from 2020 to 2022: A Retrospective Analysis Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-08 Aiming Lv, Bian Ba Zhuo Ma, De Qiong, Da Wa Zhuo Ma, Pu Bu Zhuo Ma, Donghua Yao, Da Zhen, Chunxiu Tang, Bian Ba Zhuo Ma, Youzhi Lu, Long Cai, Yutong Zhang, Jinyu Yin, Tong Ding, Lang Ji Qu Zhen, Da Wa Cang, Meng Wu, Yulan Chen, Ye Li
Purpose: To explore the effect of coronavirus disease 2019 (COVID-19) infection on neonates in plateau regions. Methods: Cases of newborns born to pregnant women infected with COVID-19 who received prenatal care or treatment at the Women and Children’s Hospital of the Tibet Autonomous Region and the Lhasa People’s Hospital between January 2020 and December 2022 (infected group) and newborns born to
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Trends of Drug-Resistant Tuberculosis in an Urban and a Rural Area in China: A 10-Year Population-Based Molecular Epidemiological Study Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-08 Peng Xu, Meng Li, Qi Jiang, Chongguang Yang, Xiangxiang Liu, Howard Takiff, Qian Gao
Objective: Drug resistance is the critical determinant for appropriate tuberculosis (TB) treatment regimens and an important indicator of the local TB burden. We aimed to investigate and compare trends in TB drug resistance in the urban Songjiang District of Shanghai from 2011 to 2020, and the rural Wusheng County of Sichuan Province from 2009 to 2020, to assess the effectiveness of local TB control
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Effectiveness of Drip Infusion of Lascufloxacin, a Novel Fluoroquinolone Antibiotic, for Patients with Pneumonia Including Chronic Lung Disease Exacerbations and Lung Abscesses Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-08 Daishi Shimada, Masafumi Seki
Background: Lascufloxacin (LSFX), a novel fluoroquinolone antibacterial agent, has recently been used as a drip infusion for treating pneumonia, apparently with good effectiveness against various bacteria, including anaerobes, and good intrapulmonary penetration. Methods: The clinical effectiveness of LSFX was retrospectively investigated for the 55 patients admitted to our hospital with pneumonia
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Association Studies of Serum Levels of TNF- α, IL-10, IFN-γ and CXCL 5 with Latent Tuberculosis Infection in Close Contacts Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-07 Jaina Razbek, Mayisha Daken, Yanggui Chen, Li Ma, Yan Zhang, Wanting Xu, Baofeng Wen, Junan Wang, Xiaomin Wang, Mingqin Cao
Purpose: Early recognition and treatment of latent tuberculosis infection(LTBI) is key to tuberculosis(TB) prevention. However, the emergence of LTBI is influenced by a combination of factors, of which the role of individual immune cytokines remains controversial. The aim of this study is to explore the influencing factors of LTBI and their effects with cytokines on LTBI. Patients and Methods: Close
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Evaluation of the Prognostic Role of Neutrophil-Lymphocyte Ratio, C-Reactive Protein-Albumin Ratio, and Platelet-Lymphocyte Ratio in Patients with the Co-Presentation of Coronary Artery Disease and COVID-19 Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-07 Xiaoqun Xu, Xinyu Zhu, Hanxin Wang, Xiao Liu, Chao Yang, Libin Liu, Tielong Chen, Long Cai, Houyong Zhu
Aim: The purpose of this study was to investigate the role of neutrophil-lymphocyte ratio (NLR), C-reactive protein-albumin ratio (CAR), and platelet-lymphocyte ratio (PLR) in the prognosis of patients with coronary artery disease (CAD) complicated with coronavirus disease 2019 (COVID-19). Methods: This study included 265 patients. A receiver operating characteristic (ROC) curve analysis was performed
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SPINK1 is a Potential Diagnostic and Prognostic Biomarker for Sepsis Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-08 Dexiu Chen, Zhangjing Shi, Xiaolan Gao, Yuxiang Yang, Xianying Lei, Yingchun Hu
Purpose: There are no satisfactory diagnostic biomarkers for sepsis. Accordingly, this study screened biomarkers valuable for sepsis diagnosis and prognosis using data-independent acquisition (DIA) combined with clinical data analysis. Patients and Methods: Serine protease inhibitor Kazal-type 1 (SPINK1) is a differentially expressed protein that was screened using DIA and bioinformatics in sepsis
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Disseminated Histoplasmosis Infection Diagnosed by Metagenomic Next-Generation Sequencing: A Case Report Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-07 Lei Qiang, Xianghui Deng, Yong Yang, Zhigan Wang, Wei Gai
Abstract: Histoplasmosis is an endemic disease caused by Histoplasma capsulatum. This systemic disease can affect various organs beyond the lungs, such as the liver, spleen, adrenal gland, and lymph nodes. The clinical symptoms can range from asymptomatic to severe, life-threatening conditions, depending on the state of the patient’s immune system. This report describes a 40-year-old male who presented
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Isolation, and Identification of Escherichia coli O157:H7 Recovered from Chicken Meat at Addis Ababa Slaughterhouses Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-06 Hailehizeb Tegegne, Kassahun Filie, Tadele Tolosa, Motuma Debelo, Eyoel Ejigu
Introduction: It is a growing concern that pathogenic bacteria can be found in poultry meat, and an additional problem is the ongoing rise in food-derived bacteria’s resistance to antibiotics. Methods: A cross-sectional study was conducted from February 2021 to March 2023. This study aimed to isolate, identify and analyze E. coli in poultry meat collected from slaughterhouses in Addis Ababa. A total
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Case Report: Pneumonia Caused by Chlamydia Psittaci and Cryptococcus Co-Infection Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-06 Anbing Zhang, Xiaoli Lao, Jinguang Liang, Xiuqiong Xia, Lei Ma, Jianping Liang
Abstract: This study presents a rare case of pneumonia caused by a co-infection of Chlamydia psittaci and Cryptococcus, confirmed by metagenomic next-generation sequencing (mNGS). The patient, who had underlying chronic hepatitis B, had adopted a stray pigeon before the onset of the disease. The primary symptoms were fever, and a productive cough. The patient recovered following treatment with moxifloxacin
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Comparison of Computed Tomography and Clinical Features Between Patients Infected with the SARS‐CoV‐2 Omicron Variant and the Original Strain Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-05 Yue Zhang, Qi Li, Jiang-Lin Xiang, Xing-Hua Li, Jing Li
Purpose: To investigate potential differences in clinical and computed tomography (CT) features between patients with the SARS‐CoV‐2 Omicron variant and the original strain. Patients and Methods: This retrospective study included 69 hospitalized patients infected with Omicron variant from November to December 2022, and 96 hospitalized patients infected with the original strain from February to March
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Antifungal Selection for the Treatment of Onychomycosis: Patient Considerations and Outcomes Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-04 Eden Axler, Shari R Lipner
Abstract: Onychomycosis, a common fungal nail infection, affects > 20% of adults over age 60 and > 50% of people over age 70. Onychomycosis may cause pain, psychosocial problems, and secondary infections, therefore meriting treatment. This review describes the range of treatment modalities, including FDA-approved systemic drugs and topical therapies. Additionally, new and emerging oral and topical
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Alginate and Chitosan-Based Hydrogel Enhance Antibacterial Agent Activity on Topical Application Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-01 Nasrul Wathoni, Cecep Suhandi, Muhammad Fadhil Ghassani Purnama, Annisa Mutmainnah, Neng Sani Nurbaniyah, Desra Widdy Syafra, Khaled M Elamin
Abstract: Untreated topical infections can become chronic, posing serious health issues. Optimal skin adherence is crucial in addressing such infections. In this context, chitosan and alginate emerge as promising candidates for use as a foundation in the development of topical hydrogels. The aim of this review is to examine the literature on topical hydrogel formulations that use chitosan and alginate
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Species Distribution, Typical Clinical Features and Risk Factors for Poor Prognosis of Super-Elderly Patients with Bloodstream Infection in China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-03-01 Jiewei Cui, Yang Li, Qingyan Du, Yuanhui Wei, Jinxia Liu, Zhixin Liang
Objective: Bloodstream infection (BSI) is characterized by high mortality, especially among these increasing super-elderly patients (≥ 85 years), and this study was conducted to understand the species distribution, typical clinical features and risk factors for poor prognosis of super-elderly patients with BSI. Methods: Based on previous work, this retrospective study was performed by reviewing an
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Roles of Nucleolar Factor RCL1 in Itraconazole Resistance of Clinical Candida albicans Under Different Stress Conditions Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-27 Jing Yang, Yan Ma, Bo Li, Zhiqin Xi, Li Zhang, Yuxi Wang, Wenli Feng
Purpose: RNA terminal phosphate cyclase like 1 (RCL1) undergoes overexpression during the immune response of Candida albicans following drug treatment. This study aims to investigate the expression levels of RCL1 in C. albicans under various stress conditions. Methods: Fifteen itraconazole (ITR)-resistant strains of clinical C. albicans, and one standard strain were employed for RCL1 sequencing, and
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Model-Informed Precision Dosing of Imipenem in an Obese Adolescent Patient with Augmented Renal Clearance and History of Schizophrenia Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-27 Yueliang Chen, Yun Han, Feng Guo, Zhenwei Yu
Abstract: Imipenem is a broad-spectrum antibiotic that has been used in treating severe infections and exhibits a time-dependent PK/PD profile. Its dose should be adjusted based on renal function. However, there is little experience with imipenem dosing in obese adolescent patients with augmented renal clearance (ARC) and history of schizophrenia. This case reported successful dosing of imipenem in
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Case Report: Encephalitis with Initial Manifestation of Orientia Tsutsugamushi Infection Detected by Metagenomic Next-Generation Sequencing Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-26 Song Han, Suge Yang, Yun Wang, Yingying Xu
Purpose: Scrub typhus, caused by Orientia tsutsugamushi, is characterized by fever, eschars, lymphadenopathy, and rash. The absence of eschars in some cases makes it difficult to distinguish it from other diseases, complicating the diagnosis process. Atypical Scrub typhus is difficult to diagnose and often leads to delayed treatment. Therefore, early diagnosis and treatment through effective detection
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Retrospective Analysis of the Efficacy and Safety of Endoscopic Spinal Tuberculosis Focus Removal versus Posterior Pedicle Lesion Removal, Bone Grafting, and Internal Fixation Combined with Drug Chemotherapy for Thoracolumbar Tuberculosis Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-26 Tuerhongjian Abudurexiti, Abuduwupuer Haibier, Alimujiang Yusufu, Kutiluke Shoukeer, Hang Lin
Objective: This study aims to investigate the clinical efficacy of endoscopic spinal tuberculosis focus removal, posterior pedicle lesion removal, bone grafting, and internal fixation combined with drug chemotherapy in treating thoracolumbar tuberculosis. It also seeks to summarize strategies for preventing complications and provide a reference for clinical treatment. Methods: We retrospectively analyzed
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Unravelling Childhood Tinea Capitis: A Multi-Dimensional Investigation Using Dermoscopy, Scanning Electron Microscopy and Mass Spectrometry Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-26 Zeyu Huang, Mingyan Chen, Yang Peng, Ruzhi Zhang
Abstract: Tinea capitis, a common cutaneous fungal infection, shows an increasing prevalence with the increasing number of pets. We present tinea capitis in a 4-year-old girl presenting without typical symptoms such as alopecia or hair breakage. After a comprehensive evaluation including dermoscopy, Wood’s light, direct KOH fluorescent staining, scanning electron microscopy, fungal culture and mass
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Characteristics of Immunocytes and Cytokines in Patients with Bloodstream Infections Caused by Carbapenem-Resistant Klebsiella pneumoniae in China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-22 Wenhui Guo, Xiang Lian, Hong Li, Lushun Jiang, Yingsha Chen, Ping Shen, Wei Yu
Objective: To evaluate the characteristics of immunocytes and cytokines associated with bloodstream infections (BSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). Methods: Patients with BSIs K. pneumoniae (BSIs-Kpn) were enrolled in our hospital between 2015 and 2022. Whole blood and serum samples were collected on the first day after diagnosis. Immunocytes and cytokines profiles were
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Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-22 Xinchao Liu, Hao Xing, Jing Lin, Jian Sun, Yu Wang, Yaxu Liu, Wei Cao, Zhengyin Liu, Taisheng Li
Background: Talaromyces marneffei is prevalent in South Asia. Latent Talaromyces marneffei infection of travellers make the diagnosis difficult. There are similarities in clinical manifestations between Talaromyces marneffei infection and lymphoma. Brain abscess is a rare form of Talaromyces marneffei infection. Case Presentation: We reported a very rare case of a 19-year-old man with HIV infection
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Clinical Characteristics of Chlamydia psittaci Infection Diagnosed by Metagenomic Next-Generation Sequencing: A Retrospective Multi-Center Study in Fujian, China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-21 Kaixiong Liu, Luling Wu, Gongping Chen, Dunhuan Zeng, Qiwei Zhong, Li Luo, Bin Song, Xiuhong Ying, Fayu Ni, Lifang Yu, Liyu Xu, Xin Lin, Xiaoyan Chen, Xin Zou, Jianhong Xiao, Yuekai Hu
Objective: This study aimed to describe and compare the epidemiological, demographic, clinical, laboratory and radiological characteristics as well as the complications, treatments, and outcomes of these patients. Methods: We retrospectively investigated clinical data of patients with C. psittaci infection (psittacosis) in eight Grade IIIA hospitals of Fujian. Metagenomic next-generation sequencing
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Evolution of Peritoneal Dialysis-Associated Peritonitis: Pathogen, Antibiotic Resistance, and the Impact of Lymphocyte Count on Treatment Outcomes Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-19 YuJian He, Guang Yang, Pengpeng Wang, Xu Wang, Zuying Xiong, Yan He, Zibo Xiong
Purpose: Antibiotic administration leads to alterations in pathogenic organisms and antibiotic resistance, posing a significant risk to peritoneal dialysis patients’ health. This study aimed to investigate changes in the cause-specific peritonitis, pathogen profiles, antibiotic resistance, and the prognostic factors among patients with peritoneal dialysis-associated peritonitis (PDAP) at our center
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Detection of HIV-1 DNA/RNA in Peripheral Blood, Bone Marrow and Femoral Head of Patients with Osteonecrosis of the Femoral Head [Letter] Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-19 Hasta Handayani Idrus, Fitriana, Setyo Adiningsih
Letter for the article Detection of HIV-1 DNA/RNA in Peripheral Blood, Bone Marrow and Femoral Head of Patients with Osteonecrosis of the Femoral Head
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Evaluation of Nanopore Sequencing for Diagnosing Pulmonary Tuberculosis Using Negative Smear Clinical Specimens Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-19 Guocan Yu, Yanqin Shen, Liwei Yao, Xudong Xu
Purpose: This study aimed to evaluate the efficacy of nanopore sequencing for diagnosing pulmonary tuberculosis (PTB) using smear-negative clinical specimens. Methods: We conducted a retrospective study based on a review of patient medical records to assess the accuracy of nanopore sequencing as a diagnostic tool for smear-negative PTB. Compared with clinical diagnosis, we determined the sensitivity
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Two Cases of Superficial Fungal Infection Caused by Non-Albicans Candida Species Manifest Greenish-black Discoloration Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-19 Leyao Shi, Yahui Feng, Dongmei Shi
Abstract: The clinical manifestation of superficial candidiasis varies depending on the infectious sites and causative Candida species that brings a great challenge to diagnose or treat without mycological or pathological evidence in clinical settings. Oral mucosal candidiasis and onychomycosis are most common types of superficial candidiasis. Typically, oral mucosal candidiasis manifests as white
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Genomic Sequencing of Clinical Cupriavidus gilardii Isolates Revealed Their Diverse Antimicrobial Resistance Mechanisms Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-16 Weichao Zhao, Huqin Yang, Yong Huang, Xin Fan, Zhaohui Tong
Purpose: Cupriavidus gilardii is an emerging multidrug-resistant pathogen found in many environments and few clinical samples. The clinical infectiousness, pathogenicity, and resistance mechanisms of C. gilardii are still unclear due to the lack of clinical and sequencing data. We need to obtain insight into the clinical characteristics, virulence, and resistance mechanisms of C. gilardii. Patients
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CTX-M, TEM, and SHV Genes in Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp Isolated from Hematologic Cancer Patients with Bacteremia in Uganda Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-16 Margaret Lubwama, David P Kateete, George Katende, Edgar Kigozi, Jackson Orem, Warren Phipps, Freddie Bwanga
Purpose: We determined the phenotypic resistance to third-generation cephalosporins, phenotypic extended spectrum beta-lactamase (ESBL) prevalence, and genotypic prevalence of ESBL-encoding genes blaCTX-M, blaTEM, and blaSHV in Enterobacteriaceae isolated from hematologic cancer patients with febrile neutropenia and bacteremia at the Uganda Cancer Institute (UCI). Patients and Methods: Blood cultures
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Evaluation of Sulfasalazine as an Adjunctive Therapy in Treating Pulmonary Pre-XDR-TB: Efficacy, Safety, and Treatment Implication Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-17 Liang Fu, Wenfei Wang, Juan Xiong, Peize Zhang, Hui Li, Xilin Zhang, Hancheng Liang, Qianting Yang, Zhaoqin Wang, Xinchun Chen, Guofang Deng, Yi Cai, Shenjie Tang
Background: The rising prevalence and limited efficacy of treatments for pre-extensively drug-resistant tuberculosis (pre-XDR-TB) underscore an immediate need for innovative therapeutic options. A combination of host-directed therapy (HDT) and anti-TB treatment presents a viable alternative for pre-XDR-TB management. Sulfasalazine (SASP), by targeting the amino acid transport system xc (xCT), potentially
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Microbiota-Based Live Biotherapeutic Products for Clostridioides Difficile Infection- The Devil is in the Details Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-15 Lea Monday, Glenn Tillotson, Teena Chopra
Abstract: Clostridioides difficile infection (CDI) remains a significant contributor to healthcare costs and morbidity due to high rates of recurrence. Currently, available antibiotic treatment strategies further disrupt the fecal microbiome and do not address the alterations in commensal flora (dysbiosis) that set the stage for CDI. Advances in microbiome-based research have resulted in the development
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A Network Pharmacology and Molecular Dynamics Simulation-Based Study of Qing Run Hua Jie Decoction in Interstitial Pneumonia Treatment Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-16 Chunxiang Li, Yingbin Lian, Yaoshen Lin, Zhihua Li
Objective: This study is dedicated to revealing the potential mechanism of Qin Run Hua Jie (QRHJ) decoction in Interstitial pneumonia (IP) treatment. Methods: The TCMSP database predicted the chemical components and targets of QRHJ decoction, and the IP-related genes were from the Genecards database. Cytoscape software was used to establish the interaction network. R package clusterProfiler was utilized
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Assessment of Knowledge and Practice of Healthcare Providers in Saudi Arabia Regarding Clostridioides difficile Infection Diagnosis and Management: A Cross-Sectional Questionnaire-Based Study Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-14 Masaad Saeed Almutairi, Faris S Alnezary, Rasil O Alsuwaylim, Ibrahim Alsulaymi, Omar A Almohammed, Abrar K Thabit
Introduction: Diagnosis of Clostridioides difficile infection (CDI) depends on clinical presentation and laboratory testing. Stool diagnostic tests are essential for effective detection of toxigenic C. difficile strains. No study to date has evaluated the readability of microbiology labs in Saudi Arabia to test for CDI and evaluated the knowledge and practice of healthcare providers regarding CDI management
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Multidrug-Resistant Proteus mirabilis Infections and Clinical Outcome at Tertiary Hospital in Riyadh, Saudi Arabia Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-14 Taghreed A Hafiz, Ghadi S Alghamdi, Zeina S Alkudmani, Ahmed S Alyami, Abeer AlMazyed, Ohoud S Alhumaidan, Murad A Mubaraki, Fawzia E Alotaibi
Background: Proteus mirabilis (P. mirabilis) is known to cause various infections, most commonly urinary tract infections, and is a threat to hospitalized patients, especially in long-stay departments that utilize invasive devices. This study aims to fill the knowledge gap regarding P. mirabilis epidemiology and antimicrobial resistance in Saudi Arabia. It investigates epidemiological patterns, resistance
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Suppurative Meningitis Complicated with Arthritis Caused by Streptococcus Suis Infection: A Case Report Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-14 Bin Shen, Luyuan Tong, Jia Qiu, Jianfeng Zhong, Zhaowei Tong, Xiaofeng Li
Background: Streptococcus suis (S. suis) is a common gram-positive bacterium in pigs. Its natural infection sites are the upper respiratory tract (especially tonsils and nasal cavity), reproductive tract and digestive tract of pigs. It is a new emerging human and animal disease. A co-morbid pathogen that can cause serious infections in humans, including meningitis, sepsis, septic arthritis, and sometimes
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Detection of HIV-1 DNA/RNA in Peripheral Blood, Bone Marrow and Femoral Head of Patients with Osteonecrosis of the Femoral Head Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-12 Kangpeng Li, Bo Liu, Rui Ma, Qiang Zhang
Background: With the increasing life expectancy of people living with HIV (PLWH) following antiretroviral therapy (ART), there is a growing prevalence of chronic diseases such as osteonecrosis of the femoral head (ONFH). Compared with the more accessible blood, the viral infection profile in bone marrow and necrotic femoral heads in PLWH remains inadequately characterized. Methods: Femoral head and
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Incidence of and Risk Factors for Third-Generation Cephalosporin-Resistant Escherichia coli Bloodstream Infections in Children Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-09 Jie Cheng, Ya Liu, Shaojun Li, Kaibin Pu, Lin Yang, Liping Tan
Objective: Third-generation cephalosporin-resistant (3GC-R) bloodstream infection (BSI) is associated with poor prognosis. We investigated the incidence of and risk factors for 3GC-R Escherichia coli (E. coli) BSI in children. Methods: Patients with E. coli BSIs who were hospitalized at the Children’s Hospital of Chongqing Medical University were retrospectively enrolled. Univariate and multivariate
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Emergence of SARS-CoV-2 with Dual-Drug Resistant Mutations During a Long-Term Infection in a Kidney Transplant Recipient Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-08 Yoko Tanino, Keisuke Nishioka, Chie Yamamoto, Yohei Watanabe, Tomo Daidoji, Masataka Kawamoto, Sayaka Uda, Shoko Kirito, Yuta Nakagawa, Yu Kasamatsu, Yoshiyuki Kawahara, Yuri Sakai, Shuji Nobori, Tohru Inaba, Bon Ota, Naohisa Fujita, Atsushi Hoshino, Yoko Nukui, Takaaki Nakaya
Introduction: Various therapeutic agents are being developed for the treatment of coronavirus disease 2019 (COVID-19). Therefore, it is crucial to accumulate information regarding the features of drug-resistant viruses to these antiviral drugs. Methods: We investigated the emergence of dual-drug resistance in a kidney transplant recipient who received sotrovimab (from day 0) and remdesivir (RDV) (from
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Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-08 Karyne Rangel, Salvatore Giovanni De-Simone
Abstract: Acinetobacter pneumonia is a significant healthcare-associated infection that poses a considerable challenge to clinicians due to its multidrug-resistant nature. Recent world events, such as the COVID-19 pandemic, have highlighted the need for effective treatment and management strategies for Acinetobacter pneumonia. In this review, we discuss lessons learned from recent world events, particularly
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Prevalence and Antimicrobial Resistance of Campylobacter Species and Associated Factors Among Under-Five Children with Diarrhea at Randomly Selected Public Health Facilities in Mekelle, Tigray, Ethiopia Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-08 Kebede Araya Abay, Girmay Desalegn, Yemane Weldu, Gebrecherkos Teame Gebrehiwot, Gebreselema Gebreyohannes, Letemicheal Negash Welekidan, Kibra Hailu Desta, Yohanns Tekle Asfaw, Ataklti Gessese Teka, Mulugeta Tilahun Gebremedhin
Background: Campylobacter species are the most predominant bacterial agents to cause diarrhea in under-five children. It poses a serious challenge to public health worldwide with ongoing acquisition of resistance to different antimicrobials with multiple patterns. Thus, this study aimed to determine the prevalence, and antimicrobial resistance of Campylobacter species, and associated factors among
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Clinical Characteristics and Drug Resistance Mechanisms of Linezolid-Non-Susceptible Enterococcus in a Tertiary Hospital in Northwest China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-08 Mengying Wu, Jia Kang, Jia Tao, Yanwen Yang, Gang Li, Wei Jia
Purpose: To understand the detection rate and distribution characteristics of Linezolid-nonsusceptible Enterococcus (LNSE) and analyze the molecular typing and main drug resistance mechanisms of LNSE, providing a theoretical basis for the precision prevention and control of LNSE hospital infections. Methods: A total of 40 LNSE strains isolated from clinical specimens between January 1, 2012, and December
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Vitamin D Improves Klebsiella-Induced Severe Pneumonia in Rats by Regulating Intestinal Microbiota Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-08 Jia-Jia Hu, Yu-Sen Lin, Jing-Cong Zhang, Yan-Hong Wang
Background: In the context of progressively uncontrolled drug resistance of bacteria, the difficulty of treating Klebsiella (KP)-induced pneumonia increases. Searching for drugs other than antibiotics has become an urgent task. Vitamin D (VD), meanwhile, is shown to be capable of treating pneumonia. Therefore, we aimed to explore the effects and mechanisms of VD on KP-infected rats. Methods: Male Sprague
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EMR Combined with CRB-65 Superior to CURB-65 in Predicting Mortality in Patients with Community-Acquired Pneumonia Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-08 Yi Sun, Hong Wang, Minghao Gu, Xingyu Zhang, Xuedong Liu, Xiudi Han
Background: Data about eosinophil-to-lymphocyte ratio (ELR) and eosinophil-to-monocyte ratio (EMR) in patients with community-acquired pneumonia (CAP) are rare. We aimed to evaluate the role of EMR and ELR in predicting disease severity and mortality in patients with CAP. Methods: A total of 454 patients (76 with severe CAP (SCAP), 378 with non-SCAP) were enrolled from November 18, 2020, and November
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Interactions and Implications of Klebsiella pneumoniae with Human Immune Responses and Metabolic Pathways: A Comprehensive Review Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-03 Ruojing Bai, Jun Guo
Abstract: Klebsiella pneumoniae (K. pneumoniae), a significant contributor to the global challenge of antibiotic resistance, is not only a ubiquitous component of the human microbiome but also a potent pathogen capable of causing a spectrum of diseases. This review provides a thorough analysis of the intricate interactions between K. pneumoniae and the human immune system, elucidating its substantial
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Risk Factors for COVID-19 Infection in Adult Patients: A Retrospective Observational Study in Japan Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-03 Akie Yoshida, Kazuhiro Furumachi, Etsuko Kumagai, Keiko Hosohata
Purpose: The aim of the study was to identify the characteristics of patients infected with coronavirus disease 2019 (COVID-19) and to determine risk factors for COVID-19 infection in Japanese patients. Patients and Methods: We conducted a single-center retrospective observational study in Japanese adult patients (≥ 20 years) who visited Kenwakai Hospital (Nagano Japan). We analyzed data of 378 patients
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Epidemiology and Azole Resistance of Clinical Isolates of Aspergillus fumigatus from a Large Tertiary Hospital in Ningxia, China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-02 Yuting Kang, Qiujie Li, Yao Yao, Chao Xu, Zhuoran Qiu, Wei Jia, Gang Li, Pengtao Wang
Purpose: The objective of this study was to determine the clinical distribution, in vitro antifungal susceptibility and underlying resistance mechanisms of Aspergillus fumigatus (A. fumigatus) isolates from the General Hospital of Ningxia Medical University between November 2021 and May 2023. Methods: Antifungal susceptibility testing was performed using the Sensititre YeastOne YO10, and isolates with
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The Recent Transmission and Associated Risk Factor of Mycobacterium tuberculosis in Golmud City, China Infect. Drug Resist. (IF 3.9) Pub Date : 2024-02-01 Zexuan Song, Wencong He, Xiaolong Cao, Aijing Ma, Ping He, Bing Zhao, Shengfen Wang, Chunfa Liu, Yanlin Zhao
Background: Tuberculosis (TB) remains a severe public health problem globally, and it is essential to comprehend the transmission pattern to control tuberculosis. Herein, we evaluated the drug-resistant characteristics, recent transmission, and associated risk factors of TB in Golmud, Qinghai, China. Methods: In this study, we performed a population-based study of patients diagnosed with TB in Golmud