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Sulfonyl thiourea derivatives from 2‐aminodiarylpyrimidines: In vitro and in silico evaluation as potential carbonic anhydrase I, II, IX, and XII inhibitors Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-16 Nguyen Dinh Thanh, Nguyen Thi Kim Giang, Do Son Hai, Vu Ngoc Toan, Hoang Thi Kim Van, Nguyen Minh Tri
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Understanding gut microbiome‐based machine learning platforms: A review on therapeutic approaches using deep learning Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-16 Shilpa Malakar, Priya Sutaoney, Harishkumar Madhyastha, Kamal Shah, Nagendra Singh Chauhan, Paromita Banerjee
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Thymoquinone potentiates anti‐cancer effects of cisplatin in oral squamous cell carcinoma via targeting oxidative stress Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-15 Mohsen Karami Fath, Kamyar Nasiri, Shabnam Ghasemzadeh, Seyedeh Tabasom Nejati, Nima Ghafari, Sahand Saeidpour Masouleh, Esmaeel Dadgar, Kimia Sadat Kazemi, Mahla Esfahaniani
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Flubendazole suppresses VEGF‐induced angiogenesis in HUVECs and exerts antitumor effects in PC‐3 cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-14 Baoyue Zhang, Jun Zhao, De Kang, Zhe Wang, Lvjie Xu, RuiFang Zheng, Ailin Liu
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Melatonin and its bioisosteres as potential therapeutic agents for the treatment of retinopathy of prematurity Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-14 N. A. Osipova, A. Y. Panova, A. M. Efremov, N. A. Lozinskaya, O. V. Beznos, L. A. Katargina
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Diethoxyphosphoryloxy‐oleanolic acid is a nanomolar‐inhibitor of butyrylcholinesterase Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-14 Anastasiya V. Petrova, Alexandr I. Poptsov, Niels V. Heise, René Csuk, Oxana B. Kazakova
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Asiatic acid inhibits rheumatoid arthritis fibroblast‐like synoviocyte growth through the Nrf2/HO‐1/NF‐κB signaling pathway Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-13 Li Zhang, Zhi‐ning Liu, Xi‐yuan Han, Xin Liu, Yang Li
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Serum exosomal miR‐3662 down‐regulates the expression of RBMS3 to promote malignant progression and gemcitabine resistance of breast cancer cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-13 Xiang Li, Xu Chu, Hao Wang, Ling Xiang, Xuandi Yue
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Investigating the effect of polymerase inhibitors on cellular proliferation: Computational studies, cytotoxicity, CDK1 inhibitory potential, and LC‐MS/MS cancer cell entrapment assays Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-12 Faten Farouk, Ibrahim M. Ibrahim, Salma Sherif, Heba Gamal Abdelhamed, Marwa Sharaky, Ahmed A. Al‐Karmalawy
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Brucine alleviates fibroblast‐like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-09 Qian Zhang, Gaodan Wang, Bin Xu
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Saikosaponin D mitigate pilocarpine‐induced astrocyte injury by regulating the NLRP3/caspase‐1 signaling pathway Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-09 Jun‐yan Liu, Yu‐ling Shen, Jing‐yi Zhu, Dong‐dong Yang
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Synthesis, in silico screening, and biological evaluation of novel pyridine congeners as anti‐epileptic agents targeting AMPA (α‐amino‐3‐hydroxy‐5‐methylisoxazole) receptors Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-08 Shivani Tyagi, Rakhi Mishra, Avijit Mazumder, Rupa Mazumder, Gurvinder Singh, Pratibha Pandey
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Ag2O‐TiO2‐NTs enhance osteogenic activity in vitro by modulating TNF‐α/β‐catenin signaling in bone marrow‐derived mesenchymal stem cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-08 Zhan‐Peng Zeng, Chang‐Rong Lai, Wei‐Jie Zheng
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Design, synthesis, and biological evaluation of novel quinoxaline aryl ethers as anticancer agents Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-08 Srinuvasu Nakka, Asif Raza, Kosana Sai Chaitanya, Naga Venkata Madhusudhan Rao Bandaru, Ala Chandu, Sankaranarayanan Murugesan, Nagaraju Devunuri, Arun K. Sharma, Kondapalli Venkata Gowri Chandrasekhar
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Computational analysis followed by in vitro studies to explore cytokines (TNF‐α, IL‐6 and IL‐1β) inhibition potential of the new natural molecule polonilignan Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-07 Pragya Paramita Pal, P. S. Lakshmi Soukya, Suraj Gupta, Hiroshi Araya, Yoshinori Fujimoto, Ahil Sajeli Begum
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Curcumin activates the JNK signaling pathway to promote ferroptosis in colon cancer cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-06 Wei Xin, Yong Zhang
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Biotin‐new indocyanine green conjugate: Synthesis, in vitro photocytotoxicity and in vivo biodistribution Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-06 Shengping Liu, Fang Ding, Wei Xu, Liangrui Miu, Yuxiang Tang, Defeng Xu, Tianyu Zhu, Hang Hu
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Caffeic acid‐grafted chitooligosaccharides downregulate MAPK and NF‐kB in RAW264.7 cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-06 Van‐Hoai Bui, Hong‐Tham N. Vo, Se‐Kwon Kim, Dai‐Nghiep Ngo
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Design, synthesis, in silico molecular docking, and ADMET studies of quinoxaline‐isoxazole‐piperazine conjugates as EGFR‐targeting agents Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-06 Mohammad Imtiyaz Ali, Narasimha Swamy Thirukovela, Gajjela Bharath Kumar, Gouthami Dasari, Vinitha Badithapuram, Ravinder Manchal, Srinivas Bandari
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β‐Sitosterol attenuates anlotinib resistance in non‐small cell lung cancer cells by inhibiting miR‐181a‐3p/SHQ1 signaling Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-05 Li‐huai Wang, Yin‐hui Sun, Hua Liu, Xiao Yang, Zhi Wen, Xue‐fei Tian
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Role of Qufeng Tongqiao Prescription in the protection of cerebral ischemia and associated molecular network mechanism Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-03-04 Xue Bai, Shen Wang, Na Li, Min Xu, Ji‐Lin Chen, Yan‐Ping Qian, Ting‐Hua Wang
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Methyltransferase METTL3‐mediated maturation of miR‐4654 facilitates high glucose‐induced apoptosis and oxidative stress in lens epithelial cells via decreasing SOD2 Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-26 Ming Guo, Fanfan Su, Yao Chen, Bo Su
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Cinnamaldehyde protects cardiomyocytes from oxygen‐glucose deprivation/reoxygenation‐induced lipid peroxidation and DNA damage via activating the Nrf2 pathway Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-26 Yan‐guang Li, Jiang‐hong Li, Hai‐qin Wang, Junhua Liao, Xiao‐ya Du
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Isoliquiritigenin attenuates neuroinflammation after subarachnoid hemorrhage through inhibition of NF‐κB‐mediated NLRP3 inflammasome activation Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-24 Zhang Wenfei, Tao Xiang, Chen Chen, Tao Yang, Tao Yun, Chen Zhibiao, Zhang Ge
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IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-20 Jinrong Zhou, Lixia Yao, Yuan Su, Lili Tian
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Design, synthesis, and evaluation of novel bistrifluoromethyl-based hydrazones as dual inhibitors of acetylcholinesterase and carbonic anhydrase enzymes for Alzheimer's disease Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-20 Efe Doğukan Dincel, Faika Başoğlu-Ünal, Ebru Didem Kuran, Tülay Kayra, Nurcan Aydın, Esmanur Kanber, İlhami Gülçin, Nuray Ulusoy-Güzeldemirci
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Correction to “Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells” Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-20
Ying-jie Zhu, Hu-lin Chen, Xin-jie Cai, Bang-le Zhan, Xiao-ming Liu (2024) Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical Biology & Drug Design, 103, e14390. The funding information for this article was inadvertently omitted. The correct details are included below. This work was financially supported by Project of Nanshan District Health
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Piceatannol selectively inhibited the JNK3 enzyme and augmented apoptosis through inhibition of Bcl-2/Cyt-c/caspase-dependent pathways in the oxygen–glucose deprived SHSY-5Y cell lines: In silico and in vitro study Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-21 Ravi Kumar Rajan, M. Ramanathan
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TMEM97 knockdown inhibits 5‐fluorouracil resistance by regulating epithelial‐mesenchymal transition and ABC transporter expression via inactivating the Akt/mTOR pathway in 5‐fluorouracil‐resistant colorectal cancer cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-23 Yi Xu, Yan Tang, Qiu Xu, Wenguang He
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Icariin promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by regulating USP47/SIRT1/Wnt/β-catenin Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-19 Hongrui Wang, Hongyue Zhang, Yuntong Zhang, Panfeng Wang
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Sinigrin improves cerebral ischaemia‐reperfusion injury by inhibiting the TLR4 pathway‐mediated oxidative stress Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-19 Shenglong Guo, Qi Lei, Qian Yang, Ruili Chen
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Prostaglandin E2 may clinically alleviate dry eye disease by inducing Th17 cell differentiation Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-15 Jingyao Chen, Yu Gong, Xiaoyu Sun, Nuo Chen, Zijun Zhao, Weijia Zhang, Yixin Zheng
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Design, synthesis, and anticancer evaluation of alkynylated pyrrole derivatives Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-14 Hegeng Wei, Yu Cao, Chungang Zhao, Zhanying Shao, Xiaoli Huo, Jinming Pan, Rangxiao Zhuang
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Synthesis and in vitro evaluation of antibacterial and antibiofilm activities of novel triphenylphosphonium-functionalized substituted pyrimidines Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-14 Liubov V. Muzychka, Nataliia I. Humeniuk, Iryna O. Boiko, Nina O. Vrynchanu, Oleg B. Smolii
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Nitrogen-containing heterocyclic compounds: A ray of hope in depression? Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-15 Diksha Choudhary, Bhupinder Kumar, Rajwinder Kaur
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A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-13 Yash Pal Singh, Harish Kumar
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Hydromorphone hydrochloride preconditioning combined with postconditioning attenuates myocardial ischemia/reperfusion injury in rats by improving mitochondrial function and activating the PI3K/Akt signaling pathway Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-11 Liuji Qiu, Yan Yan, Guocheng Zhong, Zhiqi Hou, Yongcai Ye, Jiaying Lin, Dexing Luo
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Network pharmacology and in vitro experiments reveal sophoridine-induced apoptosis and G1 phase arrest via ROS-dependent PI3K/Akt/FoxO3a pathway activation in human bladder cancer cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-12 Yao Su, Lin Chen, Jin Yang
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HSYA prevents IL-1β-induced human chondrocyte damage in osteoarthritis by inhibiting NF-κB activation Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-07 Jiaying Shen, Qi Sheng, Manman Gao, Junhong Li, Zhen Zhang, Fuan Wang, Zhiyu Zhou, Jinping Wang
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Synthesis of peiminine derivatives and its effect on A549 lung cancer-bearing mice Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-07 Xin Jin, Jianpeng Guo, Meng Lan, Gao Li, Hui Zhang
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Miltirone suppresses ESCC cell viability and invasion by promoting E3 ligase mediated-FZD2 ubiquitination and degradation Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-07 Shi-Jie Dai, Jiang-Shun Yang, Yun-Jia Tang, Xiao-Ning Yan, Chen-Xian Gu, Pei Liu, Xiao-Feng Yuan
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Glycyrrhetinic acid alleviates atrial fibrillation by inhibiting the expression of PIM1 Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-06 Hao Liang, Na Zhang, Le Zhao, Qingsong Wang, Yu An, Hong Wang
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Capsaicin derivatives: Synthesis and biological activity Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-05 Shun Liu, Xing Zheng, Jiao Wu, Yiqian Zeng, Xueni Wei, Anfeng Li, Xu Yao
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Could natural terpenes be an alternative for the treatment of neglected tropical diseases? Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-02-02 Jacqueline Soto-Sánchez
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Inhibition of O6-methylguanine-DNA-methyltransferase (MGMT) by lomeguatrib reduces multiple myeloma cell viability and impairs DNA repair in MGMT-proficient cells Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-29 Dilara Akcora-Yildiz, Tulin Ozkan, Bekir Cetintav, Yunus Yukselten, Seyma Calis, Hatice Sevim-Nalkiran, Nezaket Turkel, Mehmet Gunduz, Mehmet Ozen, Meral Beksac, Asuman Sunguroglu
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Synthesis, molecular docking, QSTR and in-silico ADME studies of novel 1,3-thiazolidine-amide derivatives as hybrid bioactive heterocycles Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-29 Amit A. Pund, Dattatraya N. Pansare, Aniket P. Sarkate, Prathmesh P. Deshpande, Baban K. Magare
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Crocin enhances the sensitivity to paclitaxel in human breast cancer cells by reducing BIRC5 expression Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-29 Yunhao Jia, Han Yang, Jinsong Yu, Zhong Li, Guangwei Jia, Bo Ding
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Interactions of small molecule inhibitors with secreted phospholipase A2: A review of the structural data Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-29 Chantalle Crous, Anél Petzer, Jacobus P. Petzer
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The (patho)physiological roles of the individual deacylase activities of a sirtuin Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-29 Weiping Zheng
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Network pharmacology analysis and experimental evaluations of YH complex on androgenetic alopecia by regulating the androgenic-apoptotic axis Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-24 Mi Hye Kim, Woong Mo Yang
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Design, antitumor, and anti-Ras activity of propynyl-substituted harmine bases Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-24 Yongsheng Fang, Jinchai Qi, Xiaoxiao Fan, Jiahui Wang, Hao Wang, Yonggang Liu
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Betulinic acid reduces inflammation in rats with sepsis-induced myocardial dysfunction by inhibiting TLR4/MyD88/NF-κB signaling pathway Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-23 Lei Wang, Wei-yu Fei, Qian-ying Song
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Matrine inhibits cell proliferation, invasion, and stem cell formation in hepatocellular carcinoma by regulating the ELAVL1/RBM3-mediated Wnt/β-catenin signaling pathway Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-23 Chunhua Song, Hongwei Li, Zhengchun Huang, Xinfeng Chang, Wen Pan, Zhihua Zhang
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Discovery of novel chromone and acrylate-based pancreatic lipase inhibitors: Molecular modelling, synthesis, and in vitro evaluation for the treatment of obesity Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-23 Prashant S. Auti, Atish T. Paul
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Anti-tumor efficacy of emodin on colorectal cancer cells via targeting lncRNA HLA complex P5 Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-23 Chongxian Yan, Long Sun, Guobo Wang, Yuyi Yao, Jianli Shao, Weihua Zhou, Zhihua Zhu, Shuchai Luo, Li Han
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Investigation on the antipyretic mechanism of Chaiqin Qingning capsule for the treatment of fever based on network pharmacology, molecular docking, and in vitro experimental validation Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-23 Lianzhan Huang, Zhengwei Chen, Hongjin Gao, Zhen Wang, Xuansheng Ding
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In vivo anticancer study of sodium 2-[(4-oxidobenzylidene)amino]-6H-1,3,4-thiadiazine-5-olate against Ehrlich ascites carcinoma via targeting PI3K/mTOR pathway Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-23 Youstina William Rizzk, Ibrahim Mohey El-Deen, Mohammed El Behery, Ahmed A. E. Mourad, Faten Zahran Mohammed
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Regulation of UCP2 in nonalcoholic fatty liver disease: From mechanisms to natural product Chem. Bio. Drug Des. (IF 3.0) Pub Date : 2024-01-23 Liyuan Hao, Shenghao Li, Guo Chen, Xiaoyu Hu
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