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Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application Arch. Pharm. Res. (IF 6.7) Pub Date : 2024-03-16 Ya-Xiao Liu, Xiao-Mei Song, Lin-Wei Dan, Jia-Mei Tang, Yi Jiang, Chong Deng, Dong-Dong Zhang, Yu-Ze Li, Wei Wang
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Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway Arch. Pharm. Res. (IF 6.7) Pub Date : 2024-03-15 Xinyan Qu, Yingying Song, Qingjun Li, Qi Xu, Yanru Li, Huimin Zhang, Xuemei Cheng, Charles R. Mackay, Quanbo Wang, Wei Liu
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The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus Arch. Pharm. Res. (IF 6.7) Pub Date : 2024-03-14 Wenwen Ding, Xiaoxue Yang, Kaiyi Lai, Yu Jiang, Ying Liu
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New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis Arch. Pharm. Res. (IF 6.7) Pub Date : 2024-02-28 Seulah Lee, Mina Jang, Rhim Ryoo, Jongtae Roh, Sung-Kyun Ko, Ki Hyun Kim
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Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways Arch. Pharm. Res. (IF 6.7) Pub Date : 2024-01-24
Abstract Insulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza
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Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management Arch. Pharm. Res. (IF 6.7) Pub Date : 2024-01-15 Yueyue Guan, Guohua Tang, Lei Li, Jianzhong Shu, Yuhua Zhao, Li Huang, Jun Tang
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Comparative metabolism of aschantin in human and animal hepatocytes Arch. Pharm. Res. (IF 6.7) Pub Date : 2024-01-05
Abstract Aschantin, a tetrahydrofurofuran lignan with a 1,3-benzodioxole group derived from Flos Magnoliae, exhibits antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. This study compared the metabolic profiles of aschantin in human, dog, mouse, and rat hepatocytes using liquid chromatography–high-resolution mass spectrometry. The hepatic extraction ratio of aschantin among the
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Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-30
Abstract Pitavastatin, a potent 3-hydroxymethylglutaryl coenzyme A reductase inhibitor, is indicated for the treatment of hypercholesterolemia and mixed dyslipidemia. Hepatic uptake of pitavastatin is predominantly occupied by the organic anion transporting polypeptide 1B1 (OATP1B1) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene, which is a polymorphic gene that encodes
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Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-28 Shivangi Kumari, Sonam Raj, M. Arockia Babu, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti
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Dysregulation of histone deacetylases in ocular diseases Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-27 Jae Hyun Jun, Jun-Sik Kim, Leon F. Palomera, Dong-Gyu Jo
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Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-27 Maryam Dolatshahi, Ahmad Reza Bahrami, Qaiser Iftikhar Sheikh, Mohsen Ghanbari, Maryam M. Matin
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PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-27 Chang-Keun Cho, Eunvin Ko, Ju Yeon Mo, Pureum Kang, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Jung-Woo Bae, Chang-Ik Choi
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The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m6A-dependent stabilization of AURKA mRNA Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-26 Pratikshya Shrestha, Garam Kim, Hyelim Kang, Poshan Yugal Bhattarai, Hong Seok Choi
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Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-26 Meng Yan, Hao Wang, Rui Wei, Wenwen Li
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Targeting dysregulated lipid metabolism in the tumor microenvironment Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-07 Do-Hee Kim, Na-Young Song, Hyungshin Yim
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Phytochemistry and pharmacology of plants in the genus Chaenomeles Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-07 Ruoling Xu, Mengting Kuang, Ning Li
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Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-08 Chang-Keun Cho, Pureum Kang, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi
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Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-12-04 Min Chang Choi, Sang Kyum Kim, Young Jae Choi, Yong June Choi, Suntae Kim, Kyung Hwan Jegal, Sung Chul Lim, Keon Wook Kang
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Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-11-30 Xiaoping Song, Lina Wang, Wei Tang, Luyao Yuan, Qingchao Liu, Jing Li, Daidi Fan
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Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-11-09 Yujin Jin, Hyesu Jeon, Thuy Le Lam Nguyen, Lila Kim, Kyung-Sun Heo
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Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-10-07 Mi Zhang, Xindong Shui, Xiaoqing Zheng, Jong Eun Lee, Yingxue Mei, Ruomeng Li, Yuan Tian, Xiuzhi Zheng, Quling Wang, Long Wang, Dongmei Chen, Tao Zhang, Byeong Mo Kim, Jungho Kim, Tae Ho Lee
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2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-10-02 Yiyuan Xi, Soeun Kim, Thi Thanh Thuy Nguyen, Phil Jun Lee, Jujia Zheng, Zhuofeng Lin, Namki Cho
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Artemongolins A–K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-28 Chong Shang, Yun-Bao Ma, Yuan Wang, Xiao-Feng He, Tian-Ze Li, Ji-Jun Chen
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Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-30 Sunil K. Gupta, Khan Hashim Ali, Sooyeun Lee, Young Ho Seo
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Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2 Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-26 Da Eun Lee, Kun Hee Park, Joo-Hyun Hong, Seon Hee Kim, Ki-Moon Park, Ki Hyun Kim
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Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-26 Surapriya Surendranath Prabhu, Aathira Sujathan Nair, Saiprabha Vijayakumar Nirmala
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Review on pharmacological effects of gastrodin Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-25 Guirong Xiao, Rong Tang, Nan Yang, Yanhua Chen
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Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-21 Jie Xu, Aizhen Xiong, Xunjiang Wang, Xing Yan, Yilin Chen, Xuanling Ye, Zhengtao Wang, Lili Ding, Li Yang
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Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-20 Ji-Young Byeon, Chang‑Keun Cho, Pureum Kang, Se-Hyung Kim, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
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Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-09-10 Mingyue Jiang, Suman Poudel, Kyung Song
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Synthesis of Au–Ag bimetallic nanoparticles using Korean red ginseng (Panax ginseng Meyer) root extract for chemo-photothermal anticancer therapy Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-08-17 Gayeon Lee, You Jeong Lee, Yeon-Jeong Kim, Youmie Park
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Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-08-10 Maria Razzaq, Ji Ho Han, Subramaniyam Ravichandran, Jaehyun Kim, Joon-Yong Bae, Man-Seong Park, Shrute Kannappan, Woo-Chang Chung, Jin-Hyun Ahn, Moon Jung Song, Kyeong Kyu Kim
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Ubiquitin–proteasome system as a target for anticancer treatment—an update Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-08-05 Yeon Jung Kim, Yeonjoo Lee, Hyungkyung Shin, SuA Hwang, Jinyoung Park, Eun Joo Song
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Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-08-03 Aruzhan Saparbayeva, Juho Lee, Shwe Phyu Hlaing, Jihyun Kim, Dongmin Kwak, Hyunwoo Kim, Eun Hee Lee, Seonghwan Hwang, Min-Soo Kim, Hyung Ryong Moon, Yunjin Jung, Jin-Wook Yoo
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Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-08-03 Le Zhang, Yuxing Wang, Dayong Wang
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Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-07-19 Hyeonha Jang, Uttam Ojha, Ji-Hak Jeong, Keun-Gyu Park, Shin Yup Lee, You Mie Lee
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Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-06-30 Peng Jiang, Xiujuan Fu, Hong Niu, Siwei Chen, Feifei Liu, Yu Luo, Dan Zhang, Hui Lei
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Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-06-24 Jin Kyung Seok, Minhyuk Kim, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
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Paritaprevir ameliorates experimental acute lung injury in vitro and in vivo Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-06-12 Rui Ren, Xin Wang, Zehui Xu, Wanglin Jiang
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Harnessing deep learning into hidden mutations of neurological disorders for therapeutic challenges Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-06-01 Sumin Yang, Sung-Hyun Kim, Mingon Kang, Jae-Yeol Joo
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Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-05-25 Dong-Soon Im
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Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-04-25 Pureum Kang, Chang-Keun Cho, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi, Jung-Woo Bae
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Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-04-18 Ritwik Maiti, Bhumika Patel, Nrupesh Patel, Mehul Patel, Alkesh Patel, Nirav Dhanesha
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Phytochemistry and pharmacology of natural prenylated flavonoids Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-04-14 Hua-Wei Lv, Qiao-Liang Wang, Meng Luo, Meng-Di Zhu, Hui-Min Liang, Wen-Jing Li, Hai Cai, Zhong-Bo Zhou, Hong Wang, Sheng-Qiang Tong, Xing-Nuo Li
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Aspergillus co-cultures: A recent insight into their secondary metabolites and microbial interactions Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-04-10 Abdullah Alanzi, Esraa A. Elhawary, Mohamed L. Ashour, Ashaimaa Y. Moussa
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Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-26 Laongdao Thongnak, Nattavadee Pengrattanachot, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Krit Jaikumkao, Anusorn Lungkaphin
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The function, mechanisms, and clinical applications of metformin: potential drug, unlimited potentials Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-24 Jianhong Liu, Ming Zhang, Dan Deng, Xiao Zhu
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Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-23 Rania M. Salama, Samah S. Abbas, Samar F. Darwish, Al Aliaa Sallam, Noura F. Elmongy, Sara A. El Wakeel
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Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-22 Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Lee
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EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-16 Kanchan Shakhakarmi, Jo-Eun Seo, Shrawani Lamichhane, Chhitij Thapa, Sangkil Lee
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Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-13 Emad H. M. Hassanein, Ahmed M. Sayed, Omnia A. M. Abd El-Ghafar, Zainab M. M. Omar, Eman K. Rashwan, Zuhair M. Mohammedsaleh, So Young Kyung, Jae Hyeon Park, Hyung Sik Kim, Fares E. M. Ali
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Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-11 ThiKem Nguyen, Raut Pawan Kumar, Pil-Hoon Park
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Engineered fibrotic liver-targeted truncated transforming growth factor β receptor type II variant for superior anti-liver fibrosis therapy Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-11 Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
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Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-10 Hyun Young Kim, Undarmaa Otgontenger, Jun-Woo Kim, Young Joo Lee, Sang-Bum Kim, Sung Chul Lim, Young-Mi Kim, Keon Wook Kang
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Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-03-06 Yeji Hong, Su-Min Nam, Aree Moon
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Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-02-25 Ho Seon Lee, Chan Uk Heo, Young-Ho Song, Kyeong Lee, Chang-Ik Choi
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Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-02-01 Ka Man Tse, Osamu Takeuchi
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Tumor lactic acid: a potential target for cancer therapy Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-02-02 Jun-Kyu Byun
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Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-02-02 Jing Wang, Qiang She, Jianlin Du
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Distinctive role of inflammation in tissue repair and regeneration Arch. Pharm. Res. (IF 6.7) Pub Date : 2023-01-31 Bokeum Choi, Changjun Lee, Je-Wook Yu