-
A Novel DNA Aptamer Probe Recognizing Castration Resistant Prostate Cancer in vitro and in vivo Based on Cell-SELEX Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-18 Jinman Zhong, Duoduo Liu, Quanxin Yang, Jianke Ding, Xin Chen
Background: Early recognition of castration-resistant state is of significance for timely adjustment of treatment regimens and improvement of prognosis. Purpose: This study aims to screen new aptamers CRda8 and CRda21 which recognize castration resistant prostate cancer (CRPC) cells with high affinity and specificity by SELEX technology. Methods: The enrichment of specific aptamer candidates was monitored
-
Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-18 Ji-Eun Song, Hae-Jin Ko, A-Sol Kim
Purpose: Anti-obesity medications (AOMs), along with lifestyle interventions, are effective means of inducing and maintaining weight loss in patients with obesity. Although the efficacy of AOMs has been reported, there have been no direct comparisons of these drugs. Therefore, in the present study, we aimed to compare the efficacy of all the AOMs available in Korea in a real-world setting. Patients
-
Understanding Sorafenib-Induced Cardiovascular Toxicity: Mechanisms and Treatment Implications Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-18 Jue Li, Lusha Zhang, Teng Ge, Jiping Liu, Chuan Wang, Qi Yu
Abstract: Tyrosine kinase inhibitors (TKIs) have been recognized as crucial agents for treating various tumors, and one of their key targets is the intracellular site of the vascular endothelial growth factor receptor (VEGFR). While TKIs have demonstrated their effectiveness in solid tumor patients and increased life expectancy, they can also lead to adverse cardiovascular effects including hypertension
-
Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-15 Yanli Wang, Yan Liu, Yongle Wang, Ping Bai, Madelyn Rose Hallisey, Breanna Lizeth Varela, Anne Siewko, Changning Wang, Yulong Xu
Introduction: Sirtuins (SIRTs) comprise a group of histone deacetylase enzymes crucial for regulating metabolic pathways and contributing significantly to various disease mechanisms. Sirtuin 1 (SIRT1), among the seven known mammalian homologs, is extensively investigated and understood, playing a key role in neurodegenerative disorders and cancer. This study focuses on potential as a therapeutic target
-
Model-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-14 Gehang Ju, Xin Liu, Wenyu Yang, Nuo Xu, Lulu Chen, Chenchen Zhang, Qingfeng He, Xiao Zhu, Dongsheng Ouyang
Introduction: Isoniazid (INH) is a crucial first-line anti tuberculosis (TB) drug used in adults and children. However, various factors can alter its pharmacokinetics (PK). This article aims to establish a population pharmacokinetic (popPK) models repository of INH to facilitate clinical use. Methods: A literature search was conducted until August 23, 2022, using PubMed, Embase, and Web of Science
-
Qifu Yixin Formula Improves Heart Failure by Enhancing β-Arrestin2 Mediated the SUMOylation of SERCA2a Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-11 Xinting Wang, Jiahui Yang, Cheng Lu, Yinqin Hu, Zhaohui Xu, Qiqi Wan, Meng Zhang, Tianyun Shi, Zhirui Liu, Yongming Liu
Purpose: This study aimed to elucidate the protective mechanism of Traditional Chinese Medicine (TCM) Qifu Yixin formula (QFYXF) to improve heart failure (HF) by promoting β-arrestin2 (β-arr2)-mediated SERCA2a SUMOylation. Materials and Methods: The transverse aortic constriction (TAC)-induced HF mice were treated with QFYXF or carvedilol for 8 weeks. β-arr2-KO mice and their littermate wild-type (WT)
-
Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-11 Jiying Liu, Guangyao Fang, Cong Lan, Chenming Qiu, Li Yao, Qian Zhang, Jingtang Hu, Yaolei Zhang, Yongjian Yang, Yan Zhang
Purpose: Pulmonary arterial hypertension (PAH) is a devastating disease with little effective treatment. The proliferation of pulmonary artery smooth muscle cells (PASMCs) induced by the nuclear factor-κB (NF-κB) signaling activation plays a pivotal role in the pathogenesis of PAH. Forsythoside B (FTS•B) possesses inhibitory effect on NF-κB signaling pathway. The present study aims to explore the effects
-
Mechanisms of Action of Potentilla discolor Bunge in Type 2 Diabetes Mellitus Based on Network Pharmacology and Experimental Verification in Drosophila Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-11 Yinghong Li, Fanwu Wu, Jianbo Zhang, Ye Xu, Hong Chang, Yueyue Yu, Chunhua Jiang, Xiujuan Gao, Huijuan Liu, Zhen Chen, Chenxi Wu, Ji-An Li
Purpose: Type 2 diabetes mellitus (T2DM) is associated with reduced insulin uptake and glucose metabolic capacity. Potentilla discolor Bunge (PDB) has been used to treat T2DM; however, the fundamental biological mechanisms remain unclear. This study aimed to understand the active ingredients, potential targets, and underlying mechanisms through which PDB treats T2DM. Methods: Components and action
-
Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-08 Taotao Sun, Yipiao Liu, Penghui Yuan, Zhankui Jia, Jinjian Yang
Purpose: As a common male disease, erectile dysfunction (ED) seriously affects the physical and mental health of patients. In recent years, studies have continued to point out the great potential of stem cell therapy (SCT) in the treatment of ED. The purpose of this study is to comprehensively analyze the research of SCT for ED and understand the development trends and research frontiers in this field
-
UHPLC-qTOF-MS-Based Nontargeted Metabolomics to Characterize the Effects of Capsaicin on Plasma and Skin Metabolic Profiles of C57BL/6 Mice-An In vivo Experimental Study Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-05 Zhen Xiao, Simin Yu, Deng Zhang, Chunming Li
Background: Capsaicin is the main compound found in chili pepper and has complex pharmacologic effects. This study aimed to elucidate the mechanism of the effect of capsaicin on physiological processes by analyzing changes in metabolites and metabolic pathways. Methods: Female C57BL/6 mice were divided into two groups(n = 10/group) and fed with capsaicin-soybean oil solution(group T) or soybean oil(group
-
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-04 Xuqing Zhou, Xu Wang, Jiaqi Li, Mengxue Zhang, Yi Yang, Shihui Lei, Ying He, Hua Yang, Desheng Zhou, Chun Guo
Background: Annao Pingchong decoction (ANPCD) is a traditional Chinese decoction which has definite effects on treating intracerebral hemorrhage (ICH) validated through clinical and experimental studies. However, the impact of ANPCD on oxidative stress (OS) after ICH remains unclear and is worth further investigating. Aim: To investigate whether the therapeutic effects of ANPCD on ICH are related to
-
Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-04 Yaxin Wei, Min Zhu, Yan Man, Hongyi Xiao, Guimin Dong, Xinyuan Shi, Fanceng Ji
Purpose: To evaluate the effect of flumazenil antagonizing remimazolam on postoperative nausea and vomiting (PONV) after gynecologic day surgery. Patients and Methods: 141 cases of gynaecological daycase surgery patients in Weifang People’s Hospital were selected, randomized into group F (flumazenil group, 71 cases) and group C (control group, 70 cases). Dexamethasone 5 mg, flurbiprofen axetil 50 mg
-
Safety and Effectiveness of a Biosimilar Recombinant Human Growth Hormone in Children Requiring Growth Hormone Treatment: Analysis of Final Data from PATRO Children, an International, Post-Marketing Surveillance Study Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-02 Sandro Loche, Shankar Kanumakala, Philippe Backeljauw, Karl Otfried Schwab, Alfonso M Lechuga-Sancho, Altaher Esmael, Dragan Urosevic, Anca Boldea, Markus Zabransky
Purpose: Omnitrope® (somatropin) was approved as a biosimilar recombinant human growth hormone (rhGH) in 2006. Here, we report final data from the PAtients TReated with Omnitrope® (PATRO) Children study, a post-marketing surveillance study designed to monitor the long-term safety and effectiveness of this treatment in pediatric patients. Methods: The study population included all pediatric patients
-
Penehyclidine for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery Under Combined Intravenous and Inhalation Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-01 Kai Zhao, Yali Gao, Jianping Zhang, Shan Wang, Jiaqi Chen, Fenglin Guo, Sheng Wang
Purpose: We designed this study to investigate the effect of intravenous use of penehyclidine on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery. Patients and Methods: Ninety-two Women Patients (Aged ≥ 18) Scheduled for Elective Gynecologic Laparoscopy Were Enrolled in the Current Study. Patients Were Equally Randomized Assigned Into Penehyclidine group (PHC group:
-
Exploration of the in vitro Antiviral Effects and the Active Components of Changyanning Tablets Against Enterovirus 71 Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-03-02 Qiong Ge, Zhewen Zhang, Zhiming Cao, Dan Wu, Changping Xu, Jianbiao Yao, Jian Gao, Yan Feng
Purpose: This study aims to investigate the in vitro antiviral effects of the aqueous solution of Changyanning (CYN) tablets on Enterovirus 71 (EV71), and to analyze its active components. Methods: The in vitro anti-EV71 effects of CYN solution and its herbal ingredients were assessed by testing the relative viral RNA (vRNA) expression level and the cell viability rates. Material basis analysis was
-
Randomized Double-Blinded Comparison of Intermittent Boluses Phenylephrine and Norepinephrine for the Treatment of Postspinal Hypotension in Patients with Severe Pre-Eclampsia During Cesarean Section Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-29 Zheng-Bin Pan, Zhi-Min Sheng, Miao Zhu, Zhong Mei, Yan-Ping Shen, Jin-Ping Liu, Xiao-Wei Qian
Background: Norepinephrine has fewer negative effects on heart rate (HR) and cardiac output (CO) for treating postspinal hypotension (PSH) compared with phenylephrine during cesarean section. However, it remains unclear whether fetuses from patients with severe pre-eclampsia could benefit from the superiority of CO. The objective of this study was to compare the safety and efficacy of intermittent
-
A Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-29 Hilda Amekyeh, Rayan Sabra, Nashiru Billa
Abstract: Oral administration of dosage forms is convenient and beneficial in several respects. Lipid nanoparticulate dosage forms have emerged as a useful carrier system in deploying low solubility drugs systemically, particularly class II, III, and IV drugs of the Biopharmaceutics Classification System. Like other nanoparticulate delivery systems, their low size-to-volume ratio facilitates uptake
-
Synthesis of a New Series of Anthraquinone-Linked Cyclopentanone Derivatives: Investigating the Antioxidant, Antibacterial, Cytotoxic and Tyrosinase Inhibitory Activities of the Mushroom Tyrosinase Enzyme Using Molecular Docking Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-27 Janani Mullaivendhan, Idhayadhulla Akbar, Anis Ahamed, Mansour K Gatasheh, Ashraf Atef Hatamleh, Gurusamy Raman, Aseer Manilal, Sabu Kuzhunellil Raghavanpillai
Purpose: New bioactive anthraquinone derivatives are investigated for antibacterial, tyrosinase inhibitory, antioxidant cytotoxic activity, and molecular docking. Methods: The compounds were produced using the grindstone method, yielding 69 to 89%. These compounds were analyzed using IR, 1H, and 13C NMR and elemental and mass spectral methods. Additionally, the antibacterial, antioxidant, and tyrosinase
-
Effects of Remifentanil Gradual Withdrawal Combined with Postoperative Infusion on Postoperative Hyperalgesia in Patients Undergoing Laparoscopic hysterectomy: A Factorial Design, Double-Blind, Randomized Controlled Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-27 Meng Luo, Xue Han, Huan Li, Guangyue Zhou, Haoxuan Chen, Fang Gao
Background: Remifentanil-induced hyperalgesia (RIH) increases the risk of persistent postoperative pain, making early postoperative analgesic therapy ineffective and affecting postoperative patient satisfaction. This study aimed to verify the effects of gradual withdrawal of remifentanil combined with postoperative pump infusion of remifentanil on postoperative hyperalgesia and pain in patients undergoing
-
Pharmacokinetics, Pharmacodynamics, and Safety of Evocalcet (KHK7580), a Novel Calcimimetic Agent: An Open-Label, Single- and Multiple-Dose, Phase I Trial in Healthy Chinese Subjects Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-26 Xuemei He, Kazuya Narushima, Masahiro Kojima, Chisato Nagai, Kexin Li
Purpose: This study explored the pharmacokinetics (PK), pharmacodynamics (PD), and safety of evocalcet (KHK7580), a new calcimimetic agent, in healthy Chinese subjects following single and multiple doses. Methods: This was a single-center, open-label phase I trial conducted in China. The study started from the single-dose cohorts (1, 3, 6, 12 mg evocalcet, step-by-step administration) and proceeded
-
Protective Effects of Red Ginseng Against Tacrine-Induced Hepatotoxicity: An Integrated Approach with Network Pharmacology and Experimental Validation Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-23 Bong-Jo Kim, Seon-Been Bak, Su-Jin Bae, Hyo-Jung Jin, Sang Mi Park, Ye-Rim Kim, Dae-Hwa Jung, Chang-Hyun Song, Young-Woo Kim, Sang-Chan Kim, Won-Yung Lee, Sun-Dong Park
Introduction: Tacrine, an FDA-approved acetylcholinesterase inhibitor, has shown efficacy in treating Alzheimer’s disease, but its clinical use is limited by hepatotoxicity. This study investigates the protective effects of red ginseng against tacrine-induced hepatotoxicity, focusing on oxidative stress. Methods: A network depicting the interaction between compounds and targets was constructed for
-
The Effects of Different Doses of Sufentanil on Intraoperative Cardiovascular Response and Postoperative Recovery in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Study Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-23 Meng Li, Xue Li, Yong Wu, Tianyu Zhang, Mengya Li, Ying Chen
Objective: To investigate the correlation between the amount of sufentanil used during anesthesia and intraoperative hemodynamic fluctuation and postoperative recovery in patients undergoing cardiopulmonary bypass (CPB). Materials and Methods: A retrospective analysis was performed on 454 patients undergoing elective heart surgery under CPB. Patients were divided into two groups according to the amount
-
Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-23 Raden Maya Febriyanti, Jutti Levita, Ajeng Diantini
Abstract: The relationship between the immune system and metabolic diseases is complex and increasingly recognized as critical to understanding conditions like obesity, diabetes, and cardiovascular diseases. Modulation of the immune system in patients with metabolic disorders can offer several potential benefits. While the salutary impact of plant-derived bioactive compounds on metabolic and immune
-
Network Pharmacology with Metabolomics Study to Reveal the Mechanisms of Bushen Huoxue Formula in Intervertebral Disc Degeneration Treatment Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-21 Ji Guo, Shengqi Yang, Weifeng Zhai, Yue Xie, Zhan Shen, Jianpo Zhang, Yongwei Jia
Background: Intervertebral disc degeneration (IVDD) is a pathophysiological process that leads to severe back pain or neurological deficits. The Bushen Huoxue Formula (BSHXF) is a traditional herbal remedy widely used to treat diseases related to IVDD. However, its pharmacological mechanism needs further exploration. Objective: This study aimed to elucidate the mechanisms through which BSHXF treats
-
Hydroxy-Safflower Yellow A Mitigates Vascular Remodeling in Rat Pulmonary Arterial Hypertension Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-20 Xiang-Yu Ji, Cheng-Jing Lei, Shuang Kong, Han-Fei Li, Si-Yu Pan, Yu-Jing Chen, Fan-Rong Zhao, Tian-Tian Zhu
Purpose: The underlying causes of pulmonary arterial hypertension (PAH) often remain obscure. Addressing PAH with effective treatments presents a formidable challenge. Studies have shown that Hydroxysafflor yellow A (HSYA) has a potential role in PAH, While the mechanism underlies its protective role is still unclear. The study was conducted to investigate the potential mechanisms of the protective
-
Efficacy of Intravenous Administration of Esketamine in Preventing and Treating Rebound Pain After Thoracic Paravertebral Nerve Block: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-17 Xu Zeng, Xianjie Zhang, Wencai Jiang, Xinyu Zhou
Purpose: Investigating the efficacy of intraoperative fractionated intravenous esketamine in the prevention of rebound pain after cessation of thoracic paravertebral nerve blockade. Methods: One hundred and twenty patients who underwent elective thoracoscopic lobectomy were selected for the study and were randomly divided into two groups, the esketamine group was given 0.5 mg/kg and 0.3 mg/kg of esketamine
-
The Protective Effect of Roflumilast Against Acute Hepatotoxicity Caused by Methotrexate in Wistar Rats: In vivo Evaluation Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-15 Riyadh S Almalki
Introduction: Methotrexate (MTX) is one of the most widely used drugs in cancer chemotherapy and treating rheumatoid arthritis. The hepatotoxicity of MTX is one of its major side effects. Roflumilast (ROF) has been recognized to have antioxidant and anti-inflammatory activity in in-vivo and in-vitro models. The present study aimed to explore the potential protective effects of roflumilast against MTX-induced
-
Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective, Double-Blind, Randomized Controlled Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-13 Longbin Zheng, Tao Fang, Wei Zhang, Xiaojing Zhang, Zhiqiang Ren, Weimin Qin, Wenbo Liang, Qing Ma, Ning Yin
Purpose: Dexmedetomidine (Dex) is a potent and highly selective α 2-adrenergic receptor agonist. Within an appropriate dose range, Dex can effectively attenuate the surgical stress response, provide intraoperative hemodynamic stability, and improve the patient recovery quality. High-dose Dex can delay patient awakening from anesthesia and increase the incidence of bradycardia. This randomized controlled
-
Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-12 Yi-Ling Jiang, Yi Xun
Purpose: This study aimed to investigate the effect of Salvia miltiorrhiza on colorectal cancer, as well as the mechanisms involved. Methods: The active compounds of Salvia miltiorrhiza and the associated genes in colorectal cancer were sourced from publicly available databases. Targets associated with colorectal cancer were identified by searching the GeneCards and OMIM databases. Subsequently, the
-
Zishen Yutai Pills Promote Angiogenesis at the Maternal-Fetal Interface in Recurrent Spontaneous Abortion Mice by Regulating miR-187/VEGF Axis Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-12 Xiaoli Wang, Heng Hu, Xinhui Yu, Chengcheng Liang, Yanquan Han, Hongxia Chen, Jijun Chu
Ethnopharmacological Relevance: Zishen Yutai pills (ZYP), a traditional Chinese patent medicine, was listed in China in 1981. It is composed of 15 traditional Chinese medicines and has the effects of regulating menstruation, helping pregnancy, and preventing abortion. In clinical practice, it is effective in preventing habitual and threatened miscarriages, and continuing to explore its mechanism of
-
Pharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-08 Juyoung Khwarg, Soyoung Lee, In-Jin Jang, Won-Ho Kang, Hye Jung Lee, Kyu Yeon Kim, Ki-Sun Jeong, Chongho Won, Youn Woong Choi, Dae Chul Ha, RaeHoon Jung, Min-Gu Han, Won Tae Jung, Kyu-Yeol Nam, YeSeul Kim, Kyung-Sang Yu, Jaeseong Oh
Purpose: Statins are widely used in combination with omega-3 fatty acids for the treatment of patients with dyslipidemia. The aim of this study was to compare the pharmacokinetic (PK) profiles of atorvastatin and omega-3-acid ethyl esters between fixed-dose combination (FDC) and loose combination in healthy subjects. Methods: A randomized, open-label, single-dose, 2-sequence, 2-treatment, 4-period
-
A Comprehensive Study to Investigate the Tumor-Suppressive Role of Radix Bupleuri on Gastric Cancer with Network Pharmacology and Molecular Docking Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-08 Long Lv, Jinghu Du, Daorong Wang, Zeqiang Yan
Background: Gastric cancer (GC) is a common fatal malignancy. The aim of this study was to explore and validate the tumor-suppressive role and mechanism of Radix Bupleuri in GC. Methods: The active constituents of Radix Bupleuri were screened using TCMSP database. SwissTargetPrediction database was used to predict potential target genes of the compounds. GeneCards, TTD, DisGeNET, OMIM, and PharmGKB
-
Ranibizumab Biosimilars in Treating Retinal Disorders: A Cost-Effective Revolution? Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-08 Eleftherios Chatzimichail, Kristina Pfau, Zisis Gatzioufas, Georgios D Panos
Abstract: Ranibizumab, is a humanized, monoclonal antibody fragment that binds and inactivates vascular endothelial growth factor-A (VEGF-A) and VEGF-B. One of the main indications for an intravitreal treatment with ranibizumab is age-related macular degeneration (AMD), which is a retinal disease with a high worldwide socioeconomic impact. Biosimilars constitute biological products that demonstrate
-
Comparative Study Between Dexmedetomidine with Bupivacaine and Bupivacaine Alone in Erector Spinae Plane Block for Postoperative Pain Control of Posterior Lumbosacral Spine Fixation Surgeries: A Randomized Controlled Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-07 Sawsan HA Abu El Hassan, Engy A Wahsh, Abdelmaksod Mohammed Mousa, Ahmed RN Ibrahim, Emad Lotfy Mohammed
Background: As posterior lumbosacral spine fixation surgeries are common spine procedures done nowadays due to different causes and mostly accompanied with moderate-to-severe postoperative pain, so should find effective postoperative analgesia for these patients. This study aimed to observe analgesic effect of dexmedetomidine combined with bupivacaine versus bupivacaine alone for erector spinae plane
-
Remifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-07 Jun Li, Hongrui Zhu, Yu Wang, Jiaqi Chen, Keqiang He, Sheng Wang
Background: Emergence agitation (EA) is one of the most common complications in clinical general anesthesia during recovery in adults. Remifentanil and propofol can reduce the incidence of EA, but with no randomized controlled trial to evaluate their effectiveness for treating EA. This study aims to compare the effectiveness of remifentanil and propofol for treating EA following general anesthesia
-
The Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Thoracoscopic Surgery for Lung Cancer: A Prospective, Randomized, Controlled Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-05 Zhaohui Liu, Yi Jin, Lingfei Wang, Zeqing Huang
Purpose: This study was conducted to assess whether ciprofol vs propofol could affect the incidence of postoperative delirium (POD) in elderly patients with lung cancer after thoracoscopic surgery. Patients and Methods: In this study, a total of 84 elderly patients undergoing thoracoscopic surgery for lung cancer were recruited and randomized into two groups to receive anesthesia with either ciprofol
-
The Potential Application of Aloe Barbadensis Mill. as Chinese Medicine for Constipation: Mini-Review Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-03 Wei-Rui Huang, Quan-Hui Fang, Xiang-Bin Yu, Wei-Hong Ge, Yue Yu
Abstract: Aloe barbadensis Mill. has a long history of medicinal use in the annals of traditional Chinese medicine, wherein it has garnered considerable renown. Its multifaceted therapeutic properties, characterized by its anti-inflammatory and antibacterial attributes, alongside its established efficacy as a laxative agent, have been extensively documented. This review commences with an exploration
-
Developments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-03 Bradley S Miller, Jo Blair, Reiko Horikawa, Agnès Linglart, Kevin CJ Yuen
Abstract: Growth hormone (GH) replacement therapy for growth hormone deficiency (GHD) in children and adults has for over 25 years, until recently, been administered as daily injections. This daily treatment regimen often incurs a burden to patients and caregivers, leading to high rates of non-adherence and, consequently, decreased treatment efficacy outcomes. To address this shortcoming, long-acting
-
Dupilumab Treatment in Pediatric Patients Aged 6–11 Years with Severe Atopic Dermatitis Whose Disease Is Not Adequately Controlled: A Review Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-03 Michael J Cork, Simon G Danby, Ana B Rossi, Ashish Bansal
Abstract: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Children with severe AD have a multidimensional disease burden characterized by skin lesions, itching, frequent infections, sleep deprivation, and a high rate of comorbidities. These impact the mental health and overall quality of life of not only the children but also of their parents and caregivers. There are
-
Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-01 Kai Chen, Yaohui Yu, Yishu Wang, Yi Zhu, Chaoren Qin, Jintao Xu, Xiangjie Zou, Tianqi Tao, Yang Li, Yiqiu Jiang
Background: Astragalus membranaceus (AM) shows promise as a therapeutic agent for osteoarthritis (OA), a debilitating condition with high disability rates. OA exacerbation is linked to chondrocyte ferroptosis, yet the precise pharmacological mechanisms of AM remain unclear. Methods: We validated AM’s protective efficacy in an anterior cruciate ligament transection (ACLT) mouse model of OA. The Traditional
-
Berberine Nanoparticles with Enhanced in vitro Bioavailability: Characterization and Antimicrobial Activity [Retraction] Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-02 Muhammad Umar Khayam Sahibzada, Abdul Sadiq, Hani S Faidah, Muhammad Khurram, Muhammad Usman Amin, Abdul Haseeb, Maria Kakar
Retraction for the article Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity
-
Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-01 Qiang Fu, Na Han, Na Li, Ling Gui, Chen Shi, Peipei Rong, Fan Zeng, He Rao, Yuan Chen
Abstract: Pain is one of the most common clinical symptoms of cancer patients, seriously affecting the quality of life of patients and bringing heavy mental and economic burden to families and society. The treatment of cancer pain in China is facing numerous challenges, one of which includes the irrational usage of analgesic drugs in clinical practice. As a strong opioid analgesic, transdermal fentanyl
-
Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-31 Yuye Chen, Yue Liu, Hong Lv, Qian Li, Jingjia Shen, Weiyun Chen, Jia Shi, Chenghui Zhou
Background: The potential myocardial protective effect of nicorandil (NICD) in patients undergoing percutaneous coronary intervention has been established. However, its efficacy in the context of cardiac surgery remains controversial. The present study aimed to evaluate the myocardial protective effect of perioperative NICD use in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)
-
Synthesis and Characterization of a New Carbon-11 Labeled Positron Emission Tomography Radiotracer for Orexin 2 Receptors Neuroimaging Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-31 Yanli Wang, Yongle Wang, Yan Liu, Hua Cheng, Tewodros Mulugeta Dagnew, Yulong Xu, Changning Wang
Purpose: Orexin receptors (OXRs) play a crucial role in modulating various physiological and neuropsychiatric functions within the central nervous system (CNS). Despite their significance, the precise role of OXRs in the brain remains elusive. Positron emission tomography (PET) imaging is instrumental in unraveling CNS functions, and the development of specific PET tracers for OXRs is a current research
-
Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-02-01 Deshanda Kurniawan Prayoga, Diah Lia Aulifa, Arif Budiman, Jutti Levita
Abstract: Ulcer disorders including the oral mucosa, large intestine, and stomach mucosa, cause significant global health burdens. Conventional treatments such as non-steroid anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), histamine H2 receptor antagonists (H2RAs), and cytoprotective agents have drawbacks like mucosal injury, diminish gastric acid secretion, and interact with concurrent
-
Review of the Protective Mechanism of Curcumin on Cardiovascular Disease Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-30 Chunkun Yang, Qinwei Zhu, Yanbo Chen, Kui Ji, Shuanghong Li, Qian Wu, Qingquan Pan, Jun Li
Abstract: Cardiovascular diseases (CVDs) are the most common cause of death worldwide and has been the focus of research in the medical community. Curcumin is a polyphenolic compound extracted from the root of turmeric. Curcumin has been shown to have a variety of pharmacological properties over the past decades. Curcumin can significantly protect cardiomyocyte injury after ischemia and hypoxia, inhibit
-
Interactive Nutrient Process (INP) in a Generative AI of a New Drug—6-Shogaol as a Potential Case Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-27 Vladimir Badmaev
Abstract: The dynamically evolving science of pharmacology requires AI technology to advance a new path for drug development. The author proposes generative AI for future drugs, identifying suitable drug molecules, uncharacteristically to previous generations of medicines, incorporating the wisdom, experience, and intuit of traditional materia medica and the respective traditional medicine practitioners
-
In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-24 Shu-Tong Huang, Jin-Chong Luo, Guo-Hui Zhong, Li-Ping Teng, Cai-Yan Yang, Chun-Li Tang, Lin Jing, Zhong-Bo Zhou, Jing Liu, Neng Jiang
Purpose: Alzheimer’s disease (AD) is the most common neurodegenerative disease, and its multifactorial nature increases the difficulty of medical research. To explore an effective treatment for AD, a series of novel tacrine-selegiline hybrids with ChEs and MAOs inhibitory activities were designed and synthesized as multifunctional drugs. Methods: All designed compounds were evaluated in vitro for their
-
Comparison of Remimazolam versus Sevoflurane on the Postoperative Quality of Recovery in Cervical Spine Surgery: A Prospective Randomized Controlled Double-Blind Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-23 Jiwon Lee, Dong Woo Han, Na Young Kim, Keun-Su Kim, Yunil Yang, Juyeon Yang, Hye Sun Lee, Myoung Hwa Kim
Purpose: Remimazolam is a newly developed ultra-short-acting benzodiazepine. We compared overall functional recovery, including the postoperative Quality of Recovery-15 (QoR-15) questionnaire scores, between balanced inhalational anesthesia using sevoflurane and total intravenous anesthesia (TIVA) with remimazolam in patients undergoing anterior cervical discectomy and fusion (ACDF). Patients and Methods:
-
The Effect of Platelet Activity, ABCB1 Genetic Polymorphism, and Renal Function on the Development of Ticagrelor-Related Dyspnea in Patients with Acute Coronary Syndrome Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-23 Vytenis Tamakauskas, Remigijus Žaliūnas, Vaiva Lesauskaitė, Nora Kupstytė-Krištaponė, Ieva Čiapienė, Gintarė Šakalytė, Jurgita Plisienė, Vilius Skipskis, Vacis Tatarūnas
Purpose: The aim of this study was to determine the effect of ABCB1 genetic polymorphism and renal function on the occurrence of ticagrelor-related dyspnea. Patients and Methods: A total of 299 patients with acute with type 1, 2, or 3 myocardial infarction (with and without ST-segment elevation), who underwent coronary angiography and PTCA with stent implantation and were treated with antiplatelet
-
Nicotine Diminishes Alpha2-Adrenergic Receptor-Dependent Protection Against Oxidative Stress in H9c2 Cardiomyocytes Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-12 Giselle Del Calvo, Celina M Pollard, Teresa Baggio Lopez, Jordana I Borges, Malka S Suster, Anastasios Lymperopoulos
Introduction: Nicotine is a major component of cigarette smoke with various detrimental cardiovascular effects, including increased oxidative stress in the heart. Agonism of α2-adrenergic receptors (ARs), such as with dexmedetomidine, has been documented to exert cardioprotective effects against oxidative stress and related apoptosis and necroptosis. α2-ARs are membrane-residing G protein-coupled receptors
-
Immunosuppression with Generics in Liver and Kidney Transplantation: A Real-World Evidence Study Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-12 Marco Finocchietti, Maria Lucia Marino, Alessandro C Rosa, Arianna Bellini, Lucia Masiero, Massimo Cardillo, Marco Massari, Stefania Spila Alegiani, Silvia Pierobon, Eliana Ferroni, Martina Zanforlini, Olivia Leoni, Stefano Ledda, Donatella Garau, Marina Davoli, Antonio Addis, Valeria Belleudi
Purpose: This study evaluates the use, benefit-risk profile, and economic impact of generic immunosuppressants (tacrolimus-TAC, cyclosporine-CsA, and mycophenolate-MYC) in kidney and liver transplant recipients compared to brand-name drugs. Patients and Methods: A retrospective multicentre observational study, involving four Italian regions, was conducted based on the national transplant Information
-
Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-11 Haojing Song, Bo Qiu, Xue Sun, Caihui Guo, Yiting Hu, Wanjun Bai, Zhanjun Dong
Background: The objective of this study was to evaluate the effect of a high-fat meal on the pharmacokinetics and safety of 80/5 mg valsartan/amlodipine tablets in healthy subjects. Subjects and Methods: These results were derived from a bioequivalence trial where subjects were randomly assigned to take valsartan/amlodipine 80/5mg under fed conditions or after a high-fat meal contained 978.6 kilocalories
-
Synthesis and Application of a Near-Infrared Light-Emitting Fluorescent Probe for Specific Imaging of Cancer Cells with High Sensitivity and Selectivity Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-10 Shaoguang Li, Zhan Lin, Haobo Chen, Qiu Luo, Shengnan Han, Kunlong Huang, Ruichan Chen, Yuying Zhan, Bing Chen, Hong Yao
Background: The preclinical diagnosis of tumors is of great significance to cancer treatment. Near-infrared fluorescence imaging technology is promising for the in-situ detection of tumors with high sensitivity. Methods: Here, a fluorescent probe was synthesized on the basis of Au nanoclusters with near-infrared light emission and applied to fluorescent cancer cell labeling. Near-infrared methionine-N-Hydroxy
-
Huang Gan Formula Alleviates Systemic Inflammation and Uremia in Adenine-Induced Chronic Kidney Disease Rats May Associate with Modification of Gut Microbiota and Colonic Microenvironment Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-06 Jingqian Zhao, Chenyu Zhao, Tianrong Xun, Xiaokang Wang, Sui Wei, Chunxiao Ye, Mimi Zhang, Dan Guo, Xixiao Yang
Purpose: This study aims to investigate the effects of Huang Gan formula (HGF), a Chinese herbal prescription used for chronic kidney disease (CKD), on the regulation of the gut microbiota and colonic microenvironment of CKD. Methods: CKD rats were induced by 150 mg/kg adenine gavage for 4 weeks, then orally treated with or without 3.6 g/kg or 7.2 g/kg of HGF for 8 weeks. The renal function and structure
-
Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2024-01-05 Pan Lei, Wanying Shen, Huijuan Tang, Li You, Guoyi Chen, Yijun Tang, Wei Lu
Purpose: Adagrasib is a selective and reversible inhibitor of KRAS G12C, which significantly delays the progression of solid tumors. However, the absorption, distribution, metabolism, and excretion of adagrasib in vivo are unclear. This study explores the absorption and distribution of adagrasib in vivo. Methods: An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UPLC-MS/MS)
-
The Role of AMPK Signaling in Ulcerative Colitis Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2023-12-29 Yuyi Yuan, Fang Wang, Xingxing Liu, Bo Shuai, Heng Fan
Abstract: Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by inflammation and ulcer formation of the intestinal mucosa. Due to its high recurrence rate, prolonged course, limited curative options, and significant impact on patients’ quality of life, along with a notable potential for malignant transformation, UC is designated as a refractory global health
-
Different Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2023-12-29 Shuxing Zhu, Yaqing Liu, Xiuli Wang, Liang Wang, Jinru Li, Xiaoming Xue, Zhao Li, Jiaxin Liu, Xin Liu, Shuang Zhao
Background: Postoperative delirium (POD) is of great concern as a complication of surgery in older adult patients. Sedation strategies influence the development of POD. This study compared how sedation strategies administered during spinal anesthesia influenced POD in patients aged ≥ 65 years undergoing elective surgery for hip fracture repair. Patients and Methods: A randomized clinical trial was
-
A Review on the Pharmacological Aspects of Engeletin as Natural Compound Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2023-12-23 Xing Zhong, Rui Huang, Xin Chen, Yuhua Lei
Background: Engeletin (ENG) is a natural flavonoid compound known for its diverse physiological and pharmacological effects, such as anti-inflammatory, antioxidant, and immunomodulatory properties. It has garnered significant attention as a promising candidate for drug development. Objective: This article aims to comprehensively review the clinical application, pharmacological action, and potential
-
Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling Drug Des. Dev. Ther. (IF 4.8) Pub Date : 2023-12-24 Xian Sun, Xi Zhou, Weiming He, Wei Sun, Zheng Xu
Abstract: Dysregulation of the gut microbial ecosystem (GME) (eg, alterations in the gut microbiota, gut-derived metabolites, and gut barrier) may contribute to the onset and progression of extra-intestinal diseases. Previous studies have found that Traditional Chinese Medicine herbs (TCMs) play an important role in manipulating the GME, but a prominent obstacle in current TCM research is the causal