样式: 排序: IF: - GO 导出 标记为已读
-
Characterization of AST‐001 non‐clinical pharmacokinetics: A novel selective AKR1C3‐activated prodrug in mice, rats, and cynomolgus monkeys Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-03-16 Teng Meng, Donald Jung, Xiao‐Hong Cai, Zhao‐Qiang Lu, Ji‐Bing Yu, Tian‐Yang Qi, Fan‐Ying Meng, Mei‐Zhen Ruan, Jian‐Xin Duan
AST‐001 is a chemically synthesized inactive nitrogen mustard prodrug that is selectively cleaved to a cytotoxic aziridine (AST‐2660) via aldo‐keto reductase family 1 member C3 (AKR1C3). The purpose of this study was to investigate the pharmacokinetics and tissue distribution of the prodrug, AST‐001, and its active metabolite, AST‐2660, in mice, rats, and monkeys. After single and once daily intravenous
-
Aging and brain free cholesterol concentration on amyloid‐β peptide accumulation in guinea pigs Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-03-16 K. Sandy Pang, H. Benson Peng, Betty P. Li, Binyu Wen, Keumhan Noh, Runyu Xia, Anja Toscan, Sylvia Serson, Paul E. Fraser, Rommel G. Tirona, Inès A. M. de Lannoy
-
In situ evaluation of the impact of metformin or verapamil coadministration with vildagliptin on its regional absorption from the rabbit’s intestine Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-02-24 Ahmed M. Elmeniar, Mohamed A. Osman, Sanaa A. El‐Gizawy, Dimple Modi, Nitin B. Charbe, Ayman F. El‐Kattan, Mohamed El‐Tanani, Yusuf A. Haggag, Murtaza M. Tambuwala
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-02-13
No abstract is available for this article.
-
Utility of cystatin C and serum creatinine-based glomerular filtration rate equations in predicting vancomycin clearance: A population pharmacokinetics analysis in elderly Chinese patients Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-02-06 Jing Ling, Xuping Yang, Lulu Dong, Yan Jiang, Sulan Zou, Nan Hu
-
Identification and characterization of an endogenous biomarker of the renal vectorial transport (OCT2-MATE1) Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-02-02 Yanrong Ma, Xinyi Wang, Xueyan Gou, Xinan Wu
-
Computational exploration of microsomal cytochrome P450 3A1 enzyme modulation by phytochemicals of Cichorium intybus L.: Insights into drug metabolism Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-01-20 Abhishek Pathak, Satya Pal Singh, Dev Bukhsh Singh, Pranav Anjaria, Apoorv Tiwari
-
Evidence for cytochrome P450 3A4-mediated metabolic activation of SCO-267 Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2024-01-18 Cui Li, Xiaokun Li, Ali Fan, Ning He, Dongmei Wu, Hongyan Yu, Kun Wang, Weijie Jiao, Xu Zhao
-
Quantitative analysis of the impact of membrane permeability on intestinal first-pass metabolism of CYP3A substrates Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-12-12 Yugo Yasugi, Yoshiyuki Shirasaka, Ikumi Tamai
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-12-01
No abstract is available for this article.
-
Metabolism of testosterone and progesterone by cytochrome P450 2C19 allelic variants Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-10-10 Shiori Takeji, Mai Okada, Shu Hayashi, Kengo Kanamaru, Yuichi Uno, Hiromasa Imaishi, Tomohide Uno
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-10-04
No abstract is available for this article.
-
Pharmacokinetic–pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-09-07 Lin Zhou, Xiaohui Wang, Jinlan Xia, Liyuan Zhang, Lianping Xue, Qingquan Jia, Zhihui Fu, Zhi Sun
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-09-06
No abstract is available for this article.
-
Integration of artificial neural network and physiologically based biopharmaceutic models in the development of sustained-release formulations Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-08-30 Frederico Severino Martins, Luiza Borges, Rene Oliveira do Couto, Stephan Schaller, Osvaldo de Freitas
Model-informed drug development is an important area recognized by regulatory authorities and is gaining increasing interest from the generic drug industry. Physiologically based biopharmaceutics modeling (PBBM) is a valuable tool to support drug development and bioequivalence assessments. This study aimed to utilize an artificial neural network (ANN) with a multilayer perceptron (MLP) model to develop
-
Linking in vitro–in vivo extrapolations with physiologically based modeling to inform drug and formulation development Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-08-25 Rodrigo Cristofoletti, Amin Rostami-Hodjegan
CONFLICT OF INTEREST STATEMENT Research activities in RC lab at the Center for Pharmacometrics and Systems Pharmacology (CPSP) at the University of Florida are partially funded by pharmaceutical companies. ARH is employed part-time by Certara, a company that develops and supplies modeling and simulation software and services to the pharmaceutical industry. Research activities in the Center for Applied
-
Influence of Gegenqinlian decoction on pharmacokinetics and pharmacodynamics of saxagliptin in type 2 diabetes mellitus rats Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-08-18 Chao Yu, Mingyu Cui, Yifeng Yin, Fengmei Zhu, Yue Sui, Xueying Yan, Yingli Gai
-
Transition of average drug-to-antibody ratio of trastuzumab deruxtecan in systemic circulation in monkeys using a hybrid affinity capture liquid chromatography-tandem mass spectrometry Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-08-03 Hiromi Habara, Hiromi Okamoto, Yoko Nagai, Masataka Oitate, Hideo Takakusa, Nobuaki Watanabe
Trastuzumab deruxtecan (T-DXd, DS-8201a) is an antibody–drug conjugate, comprising an anti-HER2 antibody at a drug-to-antibody ratio of 7–8 with the topoisomerase I inhibitor DXd. In this study, the concentrations of antibody-conjugated DXd and total antibody were determined and observed to decrease over time following intravenous administration of T-DXd to monkeys. The drug-to-antibody ratio of T-DXd
-
Self-micellizing solid dispersion of tacrolimus: Physicochemical and pharmacokinetic characterization Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-08-01 Keisuke Makino, Ryota Tsukada, Atsushi Kambayashi, Kohei Yamada, Hideyuki Sato, Satomi Onoue
-
Irinotecan-induced gastrointestinal damage alters the expression of peptide transporter 1 and absorption of cephalexin in rats Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-07-28 Ayuko Imaoka, Tomoki Hattori, Takeshi Akiyoshi, Hisakazu Ohtani
-
Selective inhibitory effects of suberosin on CYP1A2 in human liver microsomes Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-07-13 Sanjita Paudel, Hyoje Jo, Taeho Lee, Sangkyu Lee
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-06-29
No abstract is available for this article.
-
Coming full circle: The potential utility of real-world evidence to discern predictions from a physiologically based pharmacokinetic model Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-06-22 Joseph A. Grillo, Douglas McNair, Ping Zhao
-
Model-informed drug development: The mechanistic HSK3486 physiologically based pharmacokinetic model informing dose decisions in clinical trials of specific populations Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-06-14 Miao Zhang, Zhiheng Yu, Huan Liu, Xu Wang, Haiyan Li, Xueting Yao, Dongyang Liu
-
Association between α-defensin 5 and the expression and function of P-glycoprotein in differentiated intestinal Caco-2 cells Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-06-05 Genki Yasuda, Atsuhito Kubota, Keisuke Okamoto, Katsuya Narumi, Ayako Furugen, Izumi Kato, Ayako Mori, Yoshitaka Saito, Takashi Satoh, Natsuko Takahashi-Suzuki, Ken Iseki, Masaki Kobayashi
-
Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-05-09 Jialin Mao, Fang Ma, Jesse Yu, Tom De Bruyn, Miaoran Ning, Christine Bowman, Yuan Chen
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-04-25
No abstract is available for this article.
-
Physiologically-based pharmacokinetic/pharmacodynamic modeling to predict tumor growth inhibition and the efficacious dose of selective estrogen receptor degraders in humans Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-04-27 Anjani Ganti, Sijia Yu, Danielle Sharpnack, Ellen Ingalla, Tom De Bruyn
-
In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II — Assessment of model reusability and comparison between open and non-open source-code software Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-04-21 Hamza Khaled Abdelmajed Aldibani, Arham Jamaal Rajput, Amin Rostami-Hodjegan
-
In-depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source-code software Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-04-21 Arham Jamaal Rajput, Hamza Khaled Abdelmajed Aldibani, Amin Rostami-Hodjegan
-
Develop adult extrapolation to pediatrics and pediatric dose optimization based on the physiological pharmacokinetic model of azithromycin Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-04-20 Luhua Liang, Wentao Li, Zhihao Zhang, Dingyuan Li, Sijing Pu, Rongwu Xiang, Fei Zhai
-
Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-04-09 Chieri Fujino, Taiki Kuzu, Yukine Kubo, Kurumi Hayashi, Satoshi Ueshima, Toshiya Katsura
-
Enhanced oral bioavailability of capsaicin-loaded microencapsulation complex via electrospray technology: Preparation, in vitro and in vivo evaluation Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-03-31 Yuan Zhu, Shuang Li, Haiqiao Wang, Michael Adu-Frimpong, Yuanyuan Xue, Zhengqing Gu, Jiangnan Yu, Ximing Xu
-
Norvancomycin plasma concentration monitoring in hemodialysis patients with end stage kidney disease: A retrospective cohort study Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-03-28 Liying Du, Liman Huo, Juan Hou, Xiajin Zhou, Mingfeng Liu, Teng Guo, Wei Wang, Huihui Chen, Xinran Chen
-
Exploring in vitro solubility of lamotrigine in physiologically mimetic conditions to prospect the in vivo dissolution in pediatric population Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-03-23 Edilainy Rizzieri Caleffi-Marchesini, Fernanda Belincanta Borghi-Pangoni, Julia Macente, Priscila Chiamulera-Mantovani, Josmar Mazucheli, Rodrigo Cristofoletti, Andréa Diniz
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-03-17
No abstract is available for this article.
-
Decreased plasma exposure of clopidogrel active metabolite in rats after long-term treatment with clopidogrel Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-02-27 Yani Wang, Yingrui Liu, Hongwei Yao, Xue Chen, Yantong Sun, Yingjie Guo
-
Metabolic interaction between biflavonoids in Ginkgo biloba leaves and tacrolimus Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-02-25 Jie Bai, Chao Zhang
-
Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT6 receptor occupancy from non-human primates to humans Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-02-24 Aarti Sawant-Basak, Laigao Chen, Peter Lockwood, Tracey Boyden, Angela C. Doran, Jessica Mancuso, Kenneth Zasadny, Timothy McCarthy, Evan D. Morris, Richard E. Carson, Irina Esterlis, Yiyun Huang, Nabeel Nabulsi, Beata Planeta, Terence Fullerton
-
In vitro and ex vivo experimental models for evaluation of intranasal systemic drug delivery as well as direct nose-to-brain drug delivery Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-02-03 Anja Haasbroek-Pheiffer, Suzanne Van Niekerk, Frank Van der Kooy, Theunis Cloete, Jan Steenekamp, Josias Hamman
-
Recent advances in the in vitro and in vivo methods to assess impact of P-glycoprotein and breast cancer resistance protein transporters in central nervous system drug disposition Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-01-24 Sagnik Chatterjee, Anup Arunrao Deshpande, Hong Shen
-
Metabolism and pharmacokinetic study of deuterated osimertinib Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-01-17 Xuyi Zhan, Shaoyin Bao, Xumei Li, Shaojun Zhou, Maha Raja Dahar, Nengming Lin, Xiugui Chen, Chengshan Niu, Kaige Ji, Yusheng Wu, Kui Zeng, Zhihua Tang, Lushan Yu
-
In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-01-17 Thomas Altendorfer-Kroath, Joanna Hummer, Thomas Birngruber
-
Regional distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats when orally co-administered with quercetin and paeoniflorin Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-01-13 Weilan Yu, Xiaolin Liu, Dake Cai, Juntao Zheng, Biaochang Lao, Min Huang, Guoping Zhong
-
Evaluation of bottom-up modeling of the blood–brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2023-01-11 Christine Bowman, Fang Ma, Jialin Mao, Emile Plise, Eugene Chen, Liling Liu, Shu Zhang, Yuan Chen
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-12-27
No abstract is available for this article.
-
Special Issue on Applications of in Vitro, in Vivo, and Modelling & Simulation Tools for CNS Drug Disposition Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-12-22 Li Di
This article is protected by copyright. All rights reserved.
-
Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-12-14 Ting Zhu, Yu Wu, Xue-Mei Li, Yu-Meng Jia, Huan Zhou, Li-Ping Jiang, Ting Tai, Qiong-Yu Mi, Jin-Zi Ji, Hong-Guang Xie
-
Enalapril increases the urinary excretion of metformin in rats by inducing multidrug and toxin excretion protein 1 in the kidney Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-12-09 Xue-yan Gou, Yan-fang Wu, Feng-lin Ran, Yan-rong Ma, Xin-an Wu
-
Predicting transporter mediated drug–drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where we are now and the way forward Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-11-22 Gautam Vijaywargi, Sivacharan Kollipara, Tausif Ahmed, Siddharth Chachad
-
Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-11-05 Akihiko Goto, Syunsuke Yamamoto, Shinji Iwasaki
-
In vitro–in vivo extrapolation of bexarotene metabolism in the presence of chronic kidney disease and acute kidney injury in rat using physiologically based pharmacokinetic modeling and extrapolation to human Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-11-01 Mo'tasem M. Alsmadi, Saja B. Alzughoul
-
Issue Information Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-10-27
No abstract is available for this article.
-
Intestinal absorption pathways of lisinopril: Mechanistic investigations Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-10-26 Sarah H. Elewa, Mohamed A. Osman, Ebtessam A. Essa, Amal A. Sultan
-
Physiologically based pharmacokinetic model to predict drug concentrations of breast cancer resistance protein substrates in milk Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-10-20 Tao Zhang, Peng Zou, Yingsi Fang, Yanyan Li
-
Prediction of basic drug exposure in milk using a lactation model algorithm integrated within a physiologically based pharmacokinetic model Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-10-09 Amita Pansari, Muhammad Faisal, Masoud Jamei, Khaled Abduljalil
-
The role of the efflux transporter, P-glycoprotein, at the blood–brain barrier in drug discovery Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-10-05 Benoit Cox, Johan Nicolaï, Beth Williamson
-
Evaluation of bleeding and anticoagulation markers by edoxaban and low-dose cyclosporine: A case series study Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-10-04 Toshinori Hirai, Yuri Shinogi, Makoto Ikejiri, Tomohiro Murata, Takuya Iwamoto
-
Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-10-04 Marc Le Vée, Amélie Moreau, Elodie Jouan, Claire Denizot, Yannick Parmentier, Olivier Fardel
-
Estimation of fraction of drug metabolism by a single UDP-glucuronosyl transferase enzyme using relative expression factor Biopharm. Drug Dispos. (IF 2.1) Pub Date : 2022-09-23 Tomoyo Honda, Wataru Obuchi, Yumi Nishiya, Takahiro Shibayama, Kengo Watanabe, Nobuaki Watanabe