-
Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-14 Isil Ezgi Eryilmaz, Unal Egeli, Gulsah Cecener
Redox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-...
-
Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-11 Jianqing Qiu, Ziyi Zhao, Hongyan Suo, Sarah E. Paraghamian, Gabrielle M. Hawkins, Wenchuan Sun, Xin Zhang, Tianran Hao, Beor Deng, Xiaochang Shen, Chunxiao Zhou, Victoria Bae-Jump
Emerging evidence has provided considerable insights into the integral function of reprogramming fatty acid metabolism in the carcinogenesis and progression of endometrial cancer. Linoleic acid, an...
-
The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-11 Lili Han, Jing Liu, Mireayi Shataer, Chengyong Wu, Mayinuer Niyazi
CASC21 was reported to be a hotspot gene in cervical cancer. The relationship between CASC21 genetic polymorphisms and cervical cancer has not been reported. Genetic factors influence the occurrenc...
-
Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-11 Xi Jia, Naying Liao, Yunqian Yao, Xutao Guo, Kai Chen, Pengcheng Shi
Adipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic L...
-
Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-11 Yusi Wang, Hongyan Zou, Wei Ji, Min Huang, Benhui You, Nan Sun, Yuandong Qiao, Peng Liu, Lidan Xu, Xuelong Zhang, Mengdi Cai, Ye Kuang, Songbin Fu, Wenjing Sun, Xueyuan Jia, Jie Wu
Double minutes (DMs), extrachromosomal gene fragments found within certain tumors, have been noted to carry onco- and drug resistance genes contributing to tumor pathogenesis and progression. After...
-
Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-04 Xiaoping Wang, Zhendong Zhang, Xiaolan Cao
Salidroside inhibited the proliferation of cancer cell. Nevertheless, the mechanism has not been completely clarified. The purpose of the study is to explore the mechanisms of salidroside against g...
-
Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-06 Samatha M Jain, Shruthi Nagainallur Ravichandran, Makalakshmi Murali Kumar, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Rupak Pathak, Xiao-Feng Sun, Surajit Pathak
Rectal cancer accounts for the second highest cancer-related mortality, which is predominant in Western civilizations. The treatment for rectal cancers includes surgery, radiotherapy, chemotherapy,...
-
RND1 inhibits epithelial-mesenchymal transition and temozolomide resistance of glioblastoma via AKT/GSK3-β pathway Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-05 Qian Sun, Junjie Xu, Fan’en Yuan, Yan Liu, Qianxue Chen, Lirui Guo, Huimin Dong, Baohui Liu
GBM is one of the most malignant tumor in central nervous system. The resistance to temozolomide (TMZ) is inevitable in GBM and the characterization of TMZ resistance seriously hinders clinical tre...
-
TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-03-06 Kaiwen Zhang, Xingyu Zheng, Yiqing Sun, Xinyu Feng, Xirong Wu, Wenlu Liu, Chao Gao, Ye Yan, Wenyan Tian, Yingmei Wang
Ovarian cancer (OC) is a form of gynecological malignancy that is associated with worse patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α (TOP2A) is common...
-
Role of glutaminyl-peptide cyclotransferase in breast cancer doxorubicin sensitivity Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-28 Bin Xu, Liu Yang, Lixian Yang, Ahmed Al-Maamari, Jingyu Zhang, Heng Song, Meiqi Wang, Suwen Su, Zhenchuan Song
Doxorubicin (DOX) is one of the most effective and widely used chemotherapeutic drugs. However, DOX resistance is a critical risk problem for breast cancer treatment. Previous studies have demonstr...
-
A mathematical model for predicting the spatiotemporal response of breast cancer cells treated with doxorubicin Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-27 Hugo J. M. Miniere, Ernesto A. B. F. Lima, Guillermo Lorenzo, David A. Hormuth II, Sophia Ty, Amy Brock, Thomas E. Yankeelov
Tumor heterogeneity contributes significantly to chemoresistance, a leading cause of treatment failure. To better personalize therapies, it is essential to develop tools capable of identifying and ...
-
SATB1 mediated tumor colonization and β-catenin nuclear localization are associated with colorectal cancer progression Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-22 Luan Sun, Feng Wang, Xufei Wang, Feiying Zhang, Sujuan Ma, Jinghuan Lv
Colorectal cancer (CRC) is a malignancy with high incidence and poor prognosis. It is urgent to identify valuable biomarkers for early diagnosis and potent therapeutic targets. It has been reported...
-
MiR-378a-5p exerts a radiosensitizing effect on CRC through LRP8/β-catenin axis Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-22 Guolin Hu, Pengbiao Che, Ling Deng, Lei Liu, Jia Liao, Qi Liu
MiRNAs are closely related to tumor radiosensitivity. MiR-378a-5p level is down-regulated in colorectal cancer (CRC). Therefore, this study intends to explore the role of miR-378a-5p in CRC, especi...
-
miR-10b-5p promotes tumor growth by regulating cell metabolism in liver cancer via targeting SLC38A2 Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-23 Mingzhi Xia, Jie Chen, Yingyun Hu, Bin Qu, Qianqian Bu, Haoming Shen
Metabolic reprogramming plays a critical role in hepatocarcinogenesis. However, the mechanisms regulating metabolic reprogramming in primary liver cancer (PLC) are unknown. Differentially expressed...
-
Immunotherapy resistance in solid tumors: mechanisms and potential solutions Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-22 Daniel S. Lefler, Steven A. Manobianco, Babar Bashir
While the emergence of immunotherapies has fundamentally altered the management of solid tumors, cancers exploit many complex biological mechanisms that result in resistance to these agents. These ...
-
The role of liver cancer stem cells in hepatocellular carcinoma metastasis Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-23 Qinghui Niu, Susu Ye, Liu Zhao, Yanzhi Qian, Fengchao Liu
Metastasis accounts for the vast majority of cancer deaths; however, this complex process has yet to be fully explained. To form metastases, cancer cells must undergo a series of steps, known as th...
-
MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-20 Ding Ma, Shuwen Liu, Kua Liu, Lingkai Kong, Lingjun Xiao, Qilei Xin, Chunping Jiang, Junhua Wu
Colorectal cancer (CRC) is one of the most lethal cancers. Single-cell RNA sequencing (scRNA-seq) and protein-protein interactions (PPIs) have enabled the systematic study of CRC. In our research, ...
-
M6A modification regulates tumor suppressor DIRAS1 expression in cervical cancer cells Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-19 Yu-Yan Wang, Lian-Hua Ye, An-Qi Zhao, Wei-Ran Gao, Ning Dai, Yu Yin, Xin Zhang
DIRAS family GTPase 1 (DIRAS1) has been reported as a potential tumor suppressor in other human cancer. However, its expression pattern and role in cervical cancer remain unknown. Knockdown of DIRA...
-
CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-15 Hongjie Wang, Theo Koob, Jonathan R. Fromm, Ajay Gopal, Darrick Carter, André Lieber
Multiple myeloma (MM) is an incurable malignancy of the B-cell lineage. Remarkable progress has been made in the treatment of MM with anti-CD38 monoclonal antibodies such as daratumumab and isatuxi...
-
Correction Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-13
Published in Cancer Biology & Therapy (Vol. 25, No. 1, 2024)
-
The antipsychotic drug pimozide promotes apoptosis through the RAF/ERK pathway and enhances autophagy in breast cancer cells Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-14 Ge Jiang, Xingzhi Zhou, Ye Hu, Xiaoyu Tan, Dan Wang, Lina Yang, Qinggao Zhang, Shuangping Liu
The antipsychotic drug pimozide has been demonstrated to inhibit cancer. However, the precise anti-cancer mechanism of pimozide remains unclear. The purpose of this study was to investigate the eff...
-
Influence of genetic polymorphisms in vascular endothelial-related genes on the clinical outcome of axitinib in patients with metastatic renal cell carcinoma Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-07 Kazuyuki Numakura, Ryoma Igarashi, Makoto Takahashi, Taketoshi Nara, Sohei Kanda, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Takenori Niioka, Masatomo Miura, Tomonori Habuchi
Axitinib is an oral multi-target tyrosine kinase inhibitor used for the treatment of renal cell carcinoma (RCC). Because of the severe adverse events (AEs) associated with axitinib, patients often ...
-
A landscape of checkpoint blockade resistance in cancer: underlying mechanisms and current strategies to overcome resistance Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-02-02 Ginette S. Santiago-Sánchez, Kellsye P. Fabian, James W. Hodge
The discovery of immune checkpoints and the development of immune checkpoint inhibitors (ICI) have achieved a durable response in advanced-stage cancer patients. However, there is still a high prop...
-
Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-01-30 Chun Ye, Xiao Liu, Zilun Liu, Chuxuan Pan, Xiaowei Zhang, Zhanyi Zhao, Haitao Sun
Fusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. Wh...
-
The critical role of tumor microbiome in cancer immunotherapy Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-01-19 Liu Yang, Qi Wang, Lijuan He, Xingyu Sun
In recent years, the microbiome has shown an integral role in cancer immunotherapy and has become a prominent and widely studied topic. A full understanding of the interactions between the tumor mi...
-
Mutually exclusive teams-like patterns of gene regulation characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-01-17 Manas Sehgal, Sonali Priyadarshini Nayak, Sarthak Sahoo, Jason A Somarelli, Mohit Kumar Jolly
Neuroblastoma is the most frequent extracranial pediatric tumor and leads to 15% of all cancer-related deaths in children. Tumor relapse and therapy resistance in neuroblastoma are driven by phenot...
-
Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-01-16 Qian Du, Meiying Zhang, Aiai Gao, Tao He, Mingzhou Guo
Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) is a new member of the SCAN domain family. The expression regulation...
-
Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9 Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-01-16 Fei Yan, Yue Teng, Xiaoyou Li, Yuejiao Zhong, Chunyi Li, Feng Yan, Xia He
Lung cancer is the deadliest form of malignancy and the most common subtype is non-small cell lung cancer (NSCLC). Hypoxia is a typical feature of solid tumor microenvironment. In the current study...
-
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-01-11 Brajesh P. Kaistha, Gozde Kar, Andreas Dannhorn, Amanda Watkins, Grace Opoku-Ansah, Kristina Ilieva, Stefanie Mullins, Judith Anderton, Elena Galvani, Fabien Garcon, Jean-Martin Lapointe, Lee Brown, James Hair, Tim Slidel, Nadia Luheshi, Kelli Ryan, Elizabeth Hardaker, Simon Dovedi, Rakesh Kumar, Robert W. Wilkinson, Scott A. Hammond, Jim Eyles
CD73 is a cell surface 5’nucleotidase (NT5E) and key node in the catabolic process generating immunosuppressive adenosine in cancer. Using a murine monoclonal antibody surrogate of Oleclumab, we in...
-
WYC-209 inhibited GC malignant progression by down-regulating WNT4 through RARα Cancer Biol. Ther. (IF 3.6) Pub Date : 2024-01-04 Zhenyuan Qian, Wenfa Lin, Xufan Cai, Jianzhang Wu, Kun Ke, Zaiyuan Ye, Fang Wu
Gastric cancer (GC) has been a major health burden all over the world but there are fewer promising chemotherapeutic drugs due to its multidrug resistance. It has been reported that WYC-209 suppres...
-
Correction Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-12-26
Published in Cancer Biology & Therapy (Vol. 25, No. 1, 2024)
-
Diagnostic value of 18F-PSMA-1007 PET/CT for predicting the pathological grade of prostate cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-12-20 Xiao-Bo Niu, Yan-Peng Li, Jun Wang, Xiao-Li Mei, Xue-Yan Zhao, Ting-Ting Liu, Sha-Sha Xu, Xing-Min Han, Jing-Liang Cheng
This study was designed to evaluate the diagnostic efficacy of relevant parameters of 18F-prostate-specific membrane antigen (PSMA)-1007 PET/CT in predicting the pathological grade of primary prost...
-
Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-12-12 Yangyi Chen, Yongge Chen, Weixian Liu
Chaperonin containing TCP1 subunit 6A (CCT6A) was recently discovered to be involved in cancer pathogenesis and stemness; however, its role in oral squamous cell carcinoma (OSCC) has not been repor...
-
Tumor-derived exosomal miR-1247-3p promotes angiogenesis in bladder cancer by targeting FOXO1 Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-12-10 Zonglai Liu, Dan Du, Shizhong Zhang
Tumor-derived exosomes are highly correlated with tumor progression and angiogenesis. This study was designed to probe the role of tumor-derived exosomal miR-1247-3p in mediating the angiogenesis i...
-
Elucidating structural variability in p53 conformers using combinatorial refinement strategies and molecular dynamics Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-12-10 Md Rimon Parves, Maria J. Solares, William J. Dearnaley, Deborah F. Kelly
Low molecular weight proteins and protein assemblies can now be investigated using cryo-electron microscopy (EM) as a complement to traditional structural biology techniques. It is important, howev...
-
The amino acid transporter SLC7A11 expression in breast cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-12-10 Preyanka Nath, Lutfi H. Alfarsi, Rokaya El-Ansari, Brendah K. Masisi, Busra Erkan, Ali Fakroun, Ian O. Ellis, Emad A. Rakha, Andrew R. Green
Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategies. Metabolic reprogr...
-
Red ginseng polysaccharide promotes ferroptosis in gastric cancer cells by inhibiting PI3K/Akt pathway through down-regulation of AQP3 Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-12-05 Yan Wang, Wen-Xian Guan, Yuan Zhou, Xiao-Yu Zhang, Hai-Jian Zhao
This study aims to investigate the effect of red ginseng polysaccharide (RGP) on gastric cancer (GC) development and explore its mechanism.GC cell lines AGS were treated with varying concentrations...
-
Clinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-30 Tingyu Yu, Qian Zhan, Xinyu Yan, Xiaohua Luo, Xin Wang, Xiaoqiong Tang, Hongbin Zhang, Zesong Yang, Jianbin Chen, Lin Liu, Li Wang
To explore the clinical significance and prognosis of acute myeloid leukemia (AML) patients with WT1 mutations.In total, the clinical data of 269 adult patients with non-M3 AML were considered retr...
-
CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-30 Zibo Chen, Xi Liu, Masanori Kawakami, Xiuxia Liu, Allison Baker, Aayush Bhatawadekar, Liliya Tyutyunyk-Massey, Kedar Narayan, Ethan Dmitrovsky
Cyclin-dependent Kinase 2 (CDK2) inhibition prevents supernumerary centrosome clustering. This causes multipolarity, anaphase catastrophe and apoptotic death of aneuploid cancers. This study elucid...
-
Serum ferritin level is an effective prognostic factor for lung cancer immunotherapy Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-30 Fei Wang, Guodong Deng, Ning Liang, Pingping Hu, Kuo Liu, Tong Liu, Yang Li, Meng Yuan, Li Liu, Jian Xie, Lili Qiao, Fengjun Liu, Jiandong Zhang
Immunotherapy of lung cancer has achieved promising clinical results. However, it is urgent to develop predictive biomarkers for effective immunotherapy. While ferroptosis plays a critical role in ...
-
Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-29 Hariss G Paremes Sivam, Beek Yoke Chin, Sook Yee Gan, Jia Hao Ng, Agnes Gwenhure, Elaine Wan Ling Chan
Modified macrophages, tumor-associated macrophages (TAMs), are key contributors to the survival, growth, and metastatic behavior of pancreatic ductal adenocarcinoma (PDAC) cells. Central to the rol...
-
Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-27 Yan Li, Liang Meng, Ge Lou
The function of Vasohibin-1 (VASH1) in human cancer has not been thoroughly or comprehensively examined. Here, we identified the tumor suppressor part of VASH1 across cancers, including epithelial ...
-
Mathematical modeling predicts pathways to successful implementation of combination TRAIL-producing oncolytic virus and PAC-1 to treat granulosa cell tumors of the ovary Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-27 Justin Le Sauteur-Robitaille, Powel Crosley, Mary Hitt, Adrianne L. Jenner, Morgan Craig
The development of new cancer therapies requires multiple rounds of validation from in vitro and in vivo experiments before they can be considered for clinical trials. Mathematical models assist in...
-
Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-27 Junying Zhou, Ningjing Lei, Bo Qin, Mengyu Chen, Shuai Gong, Hao Sun, Luojie Qiu, Fengling Wu, Ruixia Guo, Qian Ma, Yong Li, Lei Chang
Radioresistance is the major obstacle that affects the efficacy of radiotherapy which is an important treatment for cervical cancer. By analyzing the databases, we found that aldolase A (ALDOA), wh...
-
miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-19 Zelin Yang, Liang Yang, Zhenkai Sun, Yuxi Rong, Chenglian Bai, Qiaoxiang Dong, Lin Jian
Glioblastoma as the most common and aggressive central nervous system tumor in adults. Its prognosis and therapeutic outcome are poor due to the limited understanding of its molecular mechanism. Ap...
-
hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-18 Liang Liu, Wenze Huang
Osteosarcoma is a malignant orthopedic tumor that is frequently diagnosed in the pediatric population. Several studies have summarized the functions of circular RNAs (circRNAs) in the progression o...
-
Higher PD-1/Tim-3 expression on IFN-γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-14 Shuxin Huang, Yujie Zhao, Wenpu Lai, Jiaxiong Tan, Xue Zheng, Xianfeng Zha, Yangqiu Li, Shaohua Chen
With the success of immune checkpoint inhibitors (ICI), such as anti- programmed death-1 (PD-1) antibody for solid tumors and lymphoma immunotherapy, a number of clinical trials with ICIs have been...
-
The efficacy of induction chemotherapy or adjuvant chemotherapy added to concurrent chemoradiotherapy in T3-4N0-1M0 nasopharyngeal carcinoma: a propensity score-matched analysis Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-15 Qiulu Zhong, Danjing Luo, Xiangde Li, Qinghua Du, Qianfu Liang, Wenqi Liu, Jian Li, Xiaodong Zhu
This research aimed to assess the effectiveness of combining induction chemotherapy (IC) or adjuvant chemotherapy (AC) with concurrent chemoradiotherapy (CCRT) in patients with T3-4N0-1M0 nasophary...
-
Clinical application of molecular residual disease detection by circulation tumor DNA in solid cancers and a comparison of technologies: review article Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-13 Qiantong Dong, Chenbin Chen, Yuanbo Hu, Weiteng Zhang, Xinxin Yang, Yingxue Qi, Chan Zhu, Xiaodong Chen, Xian Shen, Weiping Ji
Molecular residual disease (MRD), detected by circulating tumor DNA (ctDNA) can be involved in the entire process of solid tumor management, including recurrence prediction, efficacy evaluation, an...
-
NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-10 Zengpei Li, Dajun Li, Tianbin Yang, Chen Yao
Laryngeal squamous cell carcinoma (LSCC), is a prevalent malignant tumor, belongs to the category of head and neck tumors. N-acetyltransferase 10 (NAT10) can alter mRNA stability through N4- acetyl...
-
MiR-597-5p inhibits carcinogenesis and macrophage recruitment in colitis-related colorectal cancer via reducing the expression of CXCL5 Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-09 Shuo Li, Miao Yu, Xiuying Wang, Bingyuan Fei
Despite being the subject of multiple cancer studies, nothing is known about miR-597-5p’s role in colitis-associated colorectal cancer (CAC). We intend to explore how miR-597-5p influences the grow...
-
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-06 William S. Streitfeld, Annamarie C. Dalton, Breege V. Howley, Philip H. Howe
The poly(rC) binding protein 1 gene (PCBP1) encodes the heterogeneous nuclear ribonucleoprotein E1 (hnRNPE1), a nucleic acid-binding protein that plays a tumor-suppressive role in the mammary epith...
-
Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-11-02 Hyeon Woong Kang, Ju Hyun Kim, Da Eun Lee, Yun Sun Lee, Myeong Jin Kim, Hyung Sun Kim, SungSoon Fang, Bo Eun Lee, Kyung Jin Lee, Jongman Yoo, Hyo Jung Kim, Joon Seong Park
Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with high morbidity and mortality rates worldwide. Owing to a lack of therapeutic options, the overall survival rate of patients with pan...
-
Acquired resistance to crizotinib in novel CDK14-ALK and CLTC-ALK fusions of ALK-positive large B-cell lymphoma identified by next-generation sequencing Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-10-31 Yuxue Xia, Lu Zhang, Wenjuan He, Huaxiong Pan, Jun Fang, Guohui Cui
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a rare subtype of non-Hodgkin lymphoma. ALK inhibitors are being tried to treat recurrent/refractory ALK+ LBCL. A majority o...
-
Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-10-25 David J. Zahavi, Rossin Erbe, Yong-Wei Zhang, Theresa Guo, Zoe X. Malchiodi, Rachael Maynard, Alexander Lekan, Rosa Gallagher, Julia Wulfkuhle, Emanuel Petricoin, Sandra A. Jablonski, Elana J. Fertig, Louis M. Weiner
Targeted monoclonal antibody therapy has emerged as a powerful therapeutic strategy for cancer. However, only a minority of patients have durable responses and the development of resistance remains...
-
EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-10-20 Zunxian Wang, Bo Wei, Shuxia Ma
Bladder cancer is one of the most common malignant tumors of the urinary system, and its incidence is increasing worldwide. However, the underlying mechanisms that trigger migration, invasion and c...
-
Dysregulation of the circ_0087502/miR-1179/TGFBR2 pathway supports gemcitabine resistance in pancreatic cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-10-16 Mingliu Chen, Xinxiu Liu, Jinpeng Lu, Haiwen Teng, Chengui Yu, Yingchun Liu, Yansong Zheng
Circular RNAs (circRNAs) are a cohort of non-coding RNAs generated by back-splicing events. Accumulating evidence supports the crucial role of circRNAs in human tumorigenesis, metastasis, and chemo...
-
Phase II study of apatinib plus exemestane in estrogen receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-10-13 Aihua Tan, Li Nong, Hongxue Wang, Yuxian Jia, Wuning Zhong, Fanghui Qin, Han Wang, Jing Tang, Yan Liu, Yongkui Lu
Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (VEGFR)-2. This study was conducted to assess the efficacy and safety of apatinib combined with exemest...
-
Function of m5C RNA methyltransferase NOP2 in high-grade serous ovarian cancer Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-10-06 Shimin Yang, Dongmei Zhou, Chunxiao Zhang, Jiangdong Xiang, Xiaowei Xi
RNA methyltransferase nucleolar protein p120 (NOP2), commonly referred to as NOP2/Sun RNA methyltransferase family member 1 (NSUN1), is involved in cell proliferation and is highly expressed in var...
-
Ruangan Lidan decoction inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4 Cancer Biol. Ther. (IF 3.6) Pub Date : 2023-09-29 Tao Si, Liyin Huang, Ting Liang, Ping Huang, Hongyu Zhang, Mingmin Zhang, Xiaoling Zhou
A growing number of studies have suggested that traditional Chinese medicine (TCM) plays an essential role in the development and occurrence of liver cancer. However, the function of Ruangan Lidan ...