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The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-03-18 Andrea Albano, Silvio Colomba, Angelo Palmese, Jessica Salvadori, Lorenzo Mencuccini, Alessio Moriconi, Federica Bellato, Carmine Malzone, Stefania Berti, Marilena Paludi, Caterina Valoti, Giuseppe Panariello, Nicola Cozzolino, Carlo Pergola
In this work we exploit Computational Fluid Dynamics (CFD) to evaluate Stirred Tank Reactor (STR) Process Engineer Parameters (PEP) and design a scale down system (SDS) to be representative of the ...
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Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-03-11 Lei Liu, Mingxiu Zheng, Rongcai Liang
In the current work, we aimed to prepare a liraglutide-loaded porous microsphere-gel composite system. By employing polyethylene glycol (PEG) as a porogenic agent and poly (lactic-co-glycolic acid)...
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Atorvastatin-loaded cubosome: a repurposed targeted delivery systems for enhanced targeting against breast cancer Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-03-09 Eman M. El-Marakby, Hend Fayez, M. A. Motaleb, Mai Mansour
Cancer ranks as one of the most challenging illnesses to deal with because progressive phenotypic and genotypic alterations in cancer cells result in resistance and recurrence. Thus, the creation o...
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Engineering nanosystems for transdermal delivery of antihypertensive drugs Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-28 Mingliang Fan, Wengang Liu, Liangfeng Zhao, Lirong Nie, Yu Wang
To control hypertension, long-term continuous antihypertensive therapeutics are required and five classes of antihypertensive drugs are frequently involved, including diuretics, β-blockers, calcium...
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Preparation of Tofacitinib Sustained-Release Tablets Using Hot Melt Extrusion Technology Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-28 Sung-Yeop Kim, Ike de la Pena, Kwon-Yeon Weon, Jun-Bom Park
This study aimed to develop a tablet that shows a drug release profile similar to the tofacitinib sustained-release tablet (Xeljanz XR®; OROS™) using hot melt extrusion technology. Tofacitinib citr...
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Nanoparticles as carriers of photosensitizers to improve photodynamic therapy in cancer Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-26 Duy Hieu Truong, Phuong Thi Thu Tran, Tuan Hiep Tran
Photodynamic therapy (PDT) has emerged as a promising non-invasive therapeutic approach for cancer treatment, offering unique advantages over conventional treatments. The combination of light activ...
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Drug Content Determination of Low-Dosed Hot-Melt Extruded Filaments using Raman Spectroscopy Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-26 Rebecca Chamberlain, Jörg Breitkreutz, Björn Fischer
The aim of this study was to evaluate the suitability of a non-disruptive Raman spectroscopic method to quantify drug concentrations below 5 w% within a polymer matrix produced by hot-melt extrusio...
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Paeoniflorin Loaded Liposomes Modified with Glycyrrhetinic Acid for Liver-Targeting: Preparation, Characterization, and Pharmacokinetic Study Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-20 Menghuan Yang, Gang Jiang, Yumeng Li, Weidong Chen, Shantang Zhang, Rulin Wang
To enhance the retention times and therapeutic efficacy of paeoniflorin (PF), a liver-targeted drug delivery system has been developed using glycyrrhetinic acid (GA) as a ligand.The development and...
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Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending colon Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-23 Fatemeh Soltani, Hossein Kamali, Abbas Akhgari, Hadi Afrasiabi Garekani, Ali Nokhodchi, Fatemeh Sadeghi
The current budesonide formulations are inadequate for addressing left-sided colitis, and patients might hesitate to use an enema for a prolonged time. This study focuses on developing a single-lay...
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Bile salt-enriched vs. non-enriched nanoparticles: Comparison of their physicochemical characteristics and release pattern Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-19 Marjan Emzhik, Amirsajad Qaribnejad, Azadeh Haeri, Simin Dadashzadeh
Bile salts were first used in the preparation of nanoparticles due to their stabilizing effects. As time went by, they attracted much attention and were increasingly employed in fabricating nanopar...
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Porous Microneedle Arrays as Promising Tools for the Quantification of Drugs in the Skin: A proof of concept study Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-16 Eyman M. Eltayib, Achmad Himawan, Usanee Detamornrat, Wildan Khairi Mukhtadi, Huanhuan Li, Luchi Li, Lalitkumar Vora, Ryan F Donnelly
This study aimed to demonstrate the potential of using porous microneedles (PMNs) as a promising tool for the non-invasive quantification of topically applied pharmaceutical products.We fabricated ...
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Quercetin nanocrystals prepared using a microfluidic chip with improved in vitro dissolution Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-14 Guangyan Zheng, Wenli Wu, Zemei Liu, Yuanju Lv, Yongming Luo, Xin Che, Lihong Wang
Objective: In order to improve the dissolution property of quercetin (QCT), the quercetin nanocrystals (QNCs) were prepared in this study. Methods: QNCs were prepared by a 100μm diameter Y-shape mi...
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Oridonin Loaded Peptide Nanovesicles Alleviate Nonalcoholic Fatty Liver Disease in Mice Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-08 Lifen Zhang, Yao Yu, Qi Wang, Xi Huang, Zheng Feng, Zhi Li
This study was to construct a nanovesicle delivery system to improve the loading efficiency and stability of ORI for the treatment of nonalcoholic fatty liver disease (NAFLD). This nanovesicles (NV...
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Preparation, in vitro anti-tumor activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-08 Xianchun Wen, Jiping Li, Hao Zhang, Xinliang Mao, Huilin Deng, Li Fan, Liling Yue, Chengchong Li, Siwen Pan
Shikonin (SHK) has been evidenced to possess effects against various cancer cells. However, poor aqueous solubility and high toxicity restrict its application. In the study, RGD-decorated liposomes...
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Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA) Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-02-02 Yun Meng, Ye Cai, Mengyao Cui, Xu Yuhang, Wu Long, Xiang Li, Xiaoqin Chu
The aim of this study was to prepare a solid self-microemulsifying drug delivery system (S-SMEDDS) of cinnamaldehyde (CA) by spray drying technique to improve the oral bioavailability of CA. The pr...
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Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-01-30 Rongrong Fu, Rui Chang, Andong Peng, Changshun Feng, Weifan Zhu, Yi Chen, Xue Tian, Rui Wang, Hui Yan, Dianlong Jia, Jun Li
To solve the problem of resistance of tumor cells to TRAIL and the inevitable side effects of imatinib during treatment, we successfully prepared a kind of multifunctional liposome that encapsulate...
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Fabrication of controlled-release polymeric microneedles containing progesterone-loaded self-microemulsions for transdermal delivery Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-01-23 Phuvamin Suriyaamporn, Porawan Aumklad, Theerasak Rojanarata, Prasopchai Patrojanasophon, Tanasait Ngawhirunpat, Boonnada Pamornpathomkul, Praneet Opanasopit
Progesterone (PG) has been approved for hormone replacement therapy to mitigate the risk of endometrial carcinoma. However, there has been a lack of success in oral PG due to its rapid degradation....
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An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin. Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-01-18 S.P Lacerda, S. Del Confetto, L. Haurie, M. Bernard, S. Faget, M.I Ré
The aim of this work was to study the possibility to use SepitrapTM as a carrier for the formulation of amorphous solid dispersions by HME (hot melt extrusion) processing aiming solubility enhancem...
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Preparation and Evaluation of Vaginal Suppo-sponges Loaded with Benzydamine, In-Vitro/In-Vivo Study Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-01-19 Noha S. El- Salamouni, Marwa A. Yakout, Gihan S. Labib, Ragwa M. Farid
Mucoadhesive dosage forms, releasing locally administered drugs in a controlled manner for vaginal candidiasis may present distinct advantages over traditional creams, ointments, or gels. This work...
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Development and efficacy evaluation of a novel water-in-oil-in-water adjuvant for an inactivated foot-and-mouth disease vaccine Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-01-12 Rong, Zhang, Yanming Wei, Xuerong Liu, Yongshu Wu
To develop a novel water-in-oil-in-water (W/O/W) adjuvant and evaluate the effect on foot-and-mouth disease (FMD) inactivated vaccine, in this study, we prepared the novel nano-emulsion adjuvant ba...
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Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time Pharm. Dev. Technol. (IF 3.4) Pub Date : 2024-01-12 Do Hwan Kim, Jun Soo Park, Min Young Jeong, In Gyu Yang, Wookyung Kim, Seung Bo Shim, Hye Seon Kim, Hyun Yang Park, Myoung Jin Ho, Myung Joo Kang
Herein, we aimed to formulate a novel oral disintegrating tablet (ODT) of aripiprazole (ARP) capable of rapid disintegration using a direct compression technique. Different ODTs were fabricated wit...
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Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser scanning microscopy, and in vivo pharmacokinetic studies Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-19 Shahinaze A. Fouad, Sara T. Khatab, Mahmoud H. Teaima, Mohamed A. El-Nabarawi, Rehab Abdelmonem
Nebivolol (NBV), a BCS class II anti-hypertensive drug, suffers from limited solubility and oral bioavailability. Nanosized ethosomes were adopted as an approach to solubilize and deliver NBV trans...
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Transethosome as a versatile nano vehicle for various indications and its regulatory insights Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Ramesh Joga, Bharathi Kannan, Sravani Yerram, Amruta Nandagawale, Manasi Gawai, Hitesh Kumar Behera, Neeraj Kumar, Parul Grover, Saurabh Srivastava, Gorav Monga, Sandeep Kumar
Transethosomes, classified as 3rd generation nanocarriers, have gained global acclaim due to their profound potential in addressing diverse medical conditions. Their superior dermal penetration, at...
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Effect of variables on exemestane-loaded albumin nanoparticles: statistical optimization and anti-cancer activity in MCF-7 cell lines Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Darshan Vyas, Sarika Wairkar
This research aimed to evaluate the effect of variables on exemestane-loaded bovine serum albumin nanoparticles (EXE-BSA NPs) to improve anti-breast cancer activity. EXE-BSA NPs were optimized usin...
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Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs: polymer materials and solvent casting micromoulding method Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Rr. Kirana Andranilla, Qonita Kurnia Anjani, Pietradewi Hartrianti, Ryan F. Donnelly, Delly Ramadon
Proteins and peptides are rapidly developing pharmaceutical products and are expected to continue growing in the future. However, due to their nature, their delivery is often limited to injection, ...
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Nose-to-brain drug delivery for the treatment of glioblastoma multiforme: nanotechnological interventions Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Nitish Kumar, Bharat Khurana, Daisy Arora
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor with a short survival rate. Extensive research is underway for the last two decades to find an effective treatment for GBM...
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Incorporation of exemestane into ternary nanosponge system for enhanced anti-tumor potential in breast cancer Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Preeti Tanaji Mane, Balaji Sopanrao Wakure, Pravin Shridhar Wakte
The present investigation reports the potential of exemestane loaded cyclodextrin based nanosponges for the treatment of breast cancer. Fourier transform infrared, and nuclear magnetic resonance (N...
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Crosslinked hydrogel loaded with chitosan-supported iron oxide and silver nanoparticles as burn wound dressing Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Mina Borhani, Saba Dadpour, Atoosa Haghighizadeh, Leila Etemad, Vahid Soheili, Bahram Memar, Farzad Vafaee, Omid Rajabi
Burns can result in infection, disability, psychosocial and economic issues. Advanced wound dressings like hydrogel absorb exudate and maintain moisture. Considering the antimicrobial properties of...
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Effects of tableting process parameters and powder lubrication levels on tablet surface temperature and moisture content Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
Punch sticking is a recurrent problem during the pharmaceutical tableting process. Powder moisture content plays a key role in the buildup of sticking; it evaporates due to increased tablet tempera...
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Extrusion-based technologies for 3D printing: a comparative study of the processability of thermoplastic polyurethane-based formulations Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Ángela Aguilar-de-Leyva, Vicente Linares, Juan Domínguez-Robles, Marta Casas, Isidoro Caraballo
Thermoplastic polyurethanes (TPU) offer excellent properties for a wide range of dosage forms. These polymers have been successfully utilized in personalized medicine production using fused deposit...
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Sucrose acetate isobutyrate (SAIB) and glyceryl monooleate (GMO) hybrid nanoparticles for bioavailability enhancement of rivaroxaban: an optimization study Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Adam A. Al-Shoubki, Mahmoud H. Teaima, Rehab Abdelmonem, Mohamed A. El-Nabarawi, Sammar Fathy Elhabal
This study aims to improve the RXB bioavailability using hybrid nanoparticles. A modified melt dispersion technique created different formulas with varying GMO-SAIB: RXB and GMO: SAIB ratios, with ...
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Scale-up in twin-screw wet granulation: impact of formulation properties Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-18 Marcel Franke, Thomas Riedel, Robin Meier, Carsten Schmidt, Peter Kleinebudde
The focus of this study was to investigate the sensitivity of different drug formulations to differences in process parameters based on previously developed scale-up strategies. Three different for...
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Emulgels: a promising topical drug delivery system for arthritis management and care Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-12 Aditi Sinha, Unnati Garg, Upendra Nagaich, Amit Chaudhary, Manisha Pandey, Neha Jain
Emulgels, hybrid formulations of emulsions and gels, offer distinct benefits viz. extended release, enhanced bioavailability, and targeted drug delivery to inflamed joints, thereby minimizing syste...
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Experimental design approach for development of carboplatin loaded chitosan modified liposomal formulation with improved topical vaginal therapeutic potential Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-06 Rati Yadav, Rohit Bhawale, Deepak N. Kapoor, Shashi Bala Singh, Neelesh Kumar Mehra
One of the most prevalent cancers affecting women globally is cervical cancer. Cervical cancer is thought to cause 570 000 new cases annually, and standard treatments can have serious side effects....
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Solusomes (novel soluplus® enriched nano-vesicular carriers) for improving the oral bioavailability of Candesartan cilexetil Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-12-06 Mohammed Abdallah, Aysha Sayed Mohamed, Mina Ibrahim Tadros, Mohamed El-Nabarawi, Mai Ahmed Tawfik
Candesartan cilexetil (CAN) is administered for treating hypertension and heart failure. CAN suffers poor oral bioavailability, owing to limited aqueous solubility, and first-pass metabolism. Solus...
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Review of inhalable nanoparticles for the pulmonary delivery of anti-tuberculosis drugs Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-23 Sowmya Ramachandran, Priyanka Prakash, Noratiqah Mohtar, K. Sudesh Kumar, Thaigarajan Parumasivam
Tuberculosis is an airborne disease caused by the pathogen, Mycobacterium tuberculosis, which predominantly affects the lungs. World Health Organization (WHO) has reported that about 85% of TB pati...
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Docetaxel liposomes for lung targeted delivery: development and evaluation Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Yishuai Liu, Zixuan Zhao, Shuhui Zhu, Yumin Cheng, Jun Liu, Tiantian Ye, Shujun Wang
Docetaxel (DTX) is an artificial semi-synthetic second-generation taxane anti-tumor drug, which is suitable for the treatment of various cancers such as lung cancer. The route of administration of ...
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Design of experiments approach on the compaction properties of co-amorphous tablets Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Florian Engelsing, Laura Buchart, Holger Grohganz
Co-amorphous systems are an evolving strategy to stabilize the amorphous form of a drug molecule with the aim of overcoming its poor water-solubility. With research focussing on the molecular level...
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Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Barbara Sterle Zorec
The necessity for personalized patient treatment has drastically increased since the contribution of genes to the differences in physiological and metabolic state of individuals have been exposed. ...
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Optimization of PLGA-DSPE hybrid nano-micelles with enhanced hydrophobic capacity for curcumin delivery Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Fatmanur Babalı Balıbey, Fatemeh Bahadori, Gamze Ergin Kizilcay, Adem Tekin, Ebru Kanimdan, Abdurrahim Kocyigit
Poly (D, L Lactic-co-Glycolic acid) (PLGA) is an FDA-approved polymer. It is distinguished from other biocompatible polymers by its feasibility of production and safety for intravenous cancer tumor...
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Electrospun PVA nanofiber mat for topical Deflazacort delivery: accentuated anti-inflammatory efficacy for wound healing Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Dalia A. Mostafa, Amira Mostafa Hashad, Doaa Abou El-ezz, Mai F. Ragab, Maha K.A. Khalifa
Asses the wound healing activity of Polyvinyl alcohol – Deflazacort (PVA-DEF) nanofibers mats synthesized by electrospinning technology.PVA-DEF nanofiber mats were created with various PVA polymer ...
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Fast dissolving microneedle patch for pronounced systemic delivery of an antihyperlipidemic drug Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Zulcaif Ahmad, Nadiah Zafar, Asif Mahmood, Rai Muhammad Sarfraz, Riffat Latif, Heba A. Gad
Fast dissolving microneedles (F-dMN) are quite a novel approach delivering specific drug molecules directly into the bloodstream, bypassing the first-pass effect. The present study reported an F-dM...
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Solid lipid nanoparticles of lutein with improved dissolution behavior and oral absorption Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Kodai Ueno, Tetsuya Matsushita, Monami Sugihara, Kohei Yamada, Hideyuki Sato, Satomi Onoue
The present study aimed to develop solid lipid nanoparticles of lutein (SLN/LT) with improved dissolution behavior and oral absorption. SLN/LT were prepared by a flash nanoprecipitation method usin...
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Optimizing formulation parameters for the development of carvedilol injectable in situ forming depots Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Majd Alrashdan, Ziad A. Shraideh, Samer R. Abulateefeh
In situ forming depots (ISFDs) represent attractive alternatives to the conventional sustained drug delivery systems. Carvedilol, a short half-life drug used on a daily basis to manage chronic cond...
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Eutectic phase transition during tablet manufacture: effect of melting point of eutectic forming drug Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-15 Hadir F. Marei, Gamal M. El Maghraby, Mona F. Arafa
The aim was to investigate eutectic transition during tableting and storage. Mixtures of lidocaine and series of NSAIDs with increasing melting point were used as model systems to guide formulators...
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In vitro evaluation and in vivo efficacy studies of a liposomal doxorubicin-loaded glycyrretinic acid formulation for the treatment of hepatocellular carcinoma Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-11-08 Mine Diril, Kemal Volkan Özdokur, Yeliz Yıldırım, H. Yeşim Karasulu
Hepatocellular carcinoma (HCC), more than 800 000 cases reported annually, is the most common primary liver cancer globally. Doxorubicin hydrochloride (Dox-HCl) is a widely used chemotherapy drug f...
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Formulation and optimization of lipid- and Poloxamer-tagged niosomes for dermal delivery of terbinafine: preparation, evaluation, and in vitro antifungal activity Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-09-11 Hamdy Abdelkader, Asmaa Abd El‐Wahab, Ahmed Osama El-Gendy, Heba A. Abou-Taleb
Fungal skin diseases are recognized as a global burden disease that affect human quality adjusted life. Terbinafine belongs to allylamine and broad-spectrum antifungal drugs but considered practica...
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Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-09-04 Khushwant S. Yadav, Hrushikesh C. Raut, Harsh P. Nijhawan
The study developed and evaluated Sorafenib Tosylate (SRT)-loaded polymeric microparticles (MPs) using biodegradable polymer polycaprolactone (PCL) as a potential inhalable carrier for NSCLC. MPs w...
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Chondroitin Sulphate-Chitosan polyelectrolyte complexes for etorocoxib transdermal delivery: in silico, in vitro and in vivo studies Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-08-31 Shereen H. Noshi, Mervat Shafik Ibrahim, Abeer Salama, Iman A. Fathy, Nihal Mohamed Elmahdy Elsayyad
Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects around 1% globally leading to joint inflammation and disability. Etorocoxib (ETR) is a potent COX-2 inhibitor traditionally u...
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Topical foam as a promising carrier system for active pharmaceutical ingredients: review of clinical studies Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-08-26 Fabiana O. Kotwiski, Elaine C. de M. C. Albuquerque, Angélica M. Lucchese
Skin disorders are preferentially treated by topical administration of medicines or cosmetics because of the possibility of local action. However, a great concern is the delivery of topical actives...
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Layered double hydroxides - poloxamer 188 nanocomposites based on exfoliation reassembling for improved cellular uptake and controlled delivery of methotrexate Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-08-16 Liang Liang, Jin Ren, Jun Dai, Jianyun Liu, Lifang Zhang, Donglin Li, Chao Yang, Jingmou Yu
Exploitation of advanced methotrexate (MTX) delivery with nanocomposites has important clinical application value. Poloxamer 188 micelle and layered double hydroxide loaded with MTX (LDH-MTX) by ex...
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Comparative evaluation of three methods for quantifying tablet brittleness Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-08-02 Jørn Sonnergaard
A low value of deformation before crushing is an obvious and understandable measure of brittleness of materials including tablets. In this article, three methods based on deformation measurement in...
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Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-28 Napoleon-Nikolaos Vrettos, Peng Wang, Yuhan Wang, Clive J. Roberts, Jinyi Xu, Hong Yao, Zheying Zhu
In the present study, novel gastroretentive bilayer tablets were developed that are promising for the once-a-day oral delivery of the drug candidate MT-1207. The gastroretentive layer consisted of ...
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Technical note: estimating longer drug shelf-life with reliability plotting Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-20 John Nicholas Zorich
A graphical plot of drug stability-study data can be extrapolated to estimate the drug’s percent degradation and therefore its shelf-life beyond the time period of the study. However, after a stati...
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A systematic review of emerging technologies to enhance the treatment of ovarian cancer Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-19 Samaneh Sepahi, Lily Kiaei, Mahmoud Kiaei, Adel Ghorani-Azam
Abstract The efficacy and safety of chemotherapy are two major challenges when it comes to treating ovarian cancer. The associated undesirable side effects of chemotherapy agents jeopardize the clinical intent and the efficiency of the therapy. Multiple studies have been published describing new developments and novel strategies utilizing the latest therapeutic and drug delivery technologies to address
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Rivaroxaban-loaded SLNs with treatment potential of deep vein thrombosis: in-vitro, in-vivo, and toxicity evaluation Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-19 Xuemei Luo, Aiman Saleem, Uswa Shafique, Sadia Sarwar, Kalim Ullah, Muhammad Imran, Alam Zeb, Fakhar ud Din
Abstract Objectives Rivaroxaban (RXB), a novel Xa inhibitor having groundbreaking therapeutic potential. However, this drug is associated with few limitations, including its pharmacokinetics related toxicities. Here, we developed RXB-loaded SLNs (RXB-SLNs) to improve its biopharmaceutical profile. Methods: High pressure homogenizer was used to prepare RXB-SLNs, followed by their particle characterization
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Development of invaethosomes and invaflexosomes for dermal delivery of clotrimazole: optimization, characterization and antifungal activity Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-18 Sureewan Duangjit, Kozo Takayama, Sureewan Bumrungthai, Jongjan Mahadlek, Tanasait Ngawhirunpat, Praneet Opanasopit
Abstract The objective of this study was to develop novel invaethosomes (I-ETS) and invaflexosomes (I-FXS) to enhance the dermal delivery of clotrimazole (CZ). Twenty model CZ-loaded I-ETS and I-FXS formulations were created according to a face-centered central composite experimental design. CZ-loaded vesicle formulations containing a constant concentration of 0.025% w/v CZ and various amounts of ethanol
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Solid amorphous formulations for enhancing solubility and inhibiting Erlotinib crystallization during gastric-to-intestinal transfer Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-15 L. Mugnier, F. Espitalier, J. Menegotto, S. Bell, M. I. Ré
Abstract The objective of this study was to improve the solubility and inhibit the crystallisation during the gastric-to-intestinal transfer of Erlotinib (ERL), a small molecule kinase inhibitor (smKI) compound class, which is classified as class II drug in the Biopharmaceutical Classification System (BCS). A screening approach combining different parameters (solubility in aqueous media, inhibitory
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Exploring the use of niosomes in cosmetics for efficient dermal drug delivery Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-14 Rana Abu-Huwaij, Adian Alkarawi, Dima Salman, Furqan Alkarawi
Abstract Dermal drug delivery has emerged as a promising alternative to traditional methods of drug administration due to its non-invasive nature and ease of use. However, the stratum corneum, the outermost layer of the skin, presents a significant barrier to drug penetration. Niosomes, self-assembled vesicular structures composed of nonionic surfactants and cholesterol, have been extensively investigated
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Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations Pharm. Dev. Technol. (IF 3.4) Pub Date : 2023-07-14 Sumit Kumar Saha, Amita Joshi, Romi Singh, Kiran Dubey
Abstract Evolving therapeutic landscape through combinatorial chemistry and high throughput screening have resulted in an increased number of poorly soluble drugs. Drug delivery strategies quickly adapted to convert these drugs into successful therapies. Amorphous solid dispersion (ASD) technology is widely employed as a drug delivery strategy by pharmaceutical industries to overcome the challenges