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Retraction: In vitro antioxidant potentials of Cyperus Rotundus L. rhizome extracts and their phytochemical analysis. Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-02-22
[This retracts the article on p. 261 in vol. 14, PMID: 29720842.].
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Genetic clonal fidelity assessment of rhizome-derived micropropagated Acorus calamus L. – A medicinally important plant by random amplified polymorphic DNA and inter-simple sequence repeat markers Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Potshangbam Nongdam,Leimapokpam Tikendra,Oinam Sushma,Thoungamba Amom,NandeibamApana Devi,Sonia Paonam,Nongthombam Bidyananda,AngambaMeetei Potshangbam,Abhijit Dey,RajkumariSanayaima Devi
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Elucidating the immunomodulatory effect of daidzein in Benzo(a)pyrene -Induced lung cancer mice model through modulation of proliferating cell nuclear antigen, NF-κB, CYP1A1, and NRF Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Hui Guan,Jianyu Feng,Wei Meng,Yandong Liu,Cuiyun Li,Chunnan Zhang,Peng Wang,HeshamS Almoallim,Velu Manikandan
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Protective effect of the traditional Korean herbal prescription, Bojangunbi-tang, on non-steroidal anti-inflammatory drug-induced small bowel injury Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Seok-Jae Ko,Minji Cho,Jinhyun Bae,Ji-Hye Park,Youngmin Bu,Beom-Joon Lee,Jae-Woo Park,Jinsung Kim,HyeHyun Yoo
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Syringin protects against cerebral ischemia and reperfusion injury via suppression of inflammatory mediators and toll-like receptor/MyD88 signaling pathway in rats Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Yihong Huang,Xiaopeng Wang,Shaobing Guan,Han Lin,Zhizhong Mei,Zhi Huang
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Antioxidant, anti-proliferative, and anti-atherosclerotic effect of phytochemicals isolated from Trachyspermum ammi with honey in RAW 264.7 and THP-1 cells Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 SunilS More,GHari Priyaa
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Preparation and anti-fatigue effects of Vicatia thibertica polysaccharide Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Meixian Guo,Xiaobo Liu,Weiwei Zhang,Jincheng Duan,Chunyan Ji,Zhengchun He,Guirong Shi
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Evaluation of the antidepressant-like activity of the aqueous extract of Crataegus aronia Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 HasanSaeed Alamri
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Morphological, biochemical, molecular marker, gas chromatography-tandem mass spectrometer analysis of garlic (Allium sativum L.) landraces in the rain shadow high hills of Kerala, India Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 JalajaS Menon,Berin Pathrose,AC Asna,RukamSingh Tomer,B Dineshkumar
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Ameliorative efficacy of oxypaeoniflorin, a traditional chinese medicine monomer against adjuvant-induced arthritic inflammation and pain Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Meng Jiang,Ke Lv
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Evaluation on the skin anti-aging potential of an aqueous extract from Oenanthe javanica (Blume) DC Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Chang-Jin Lim,Hye-Won Lim,Yu-Hua Huang,Minsik Park
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Anticarcinogenic effect of brucine on DMBA-induced skin cancer via regulation of PI3K/AKT signaling pathway Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Wei Chen,Jie Wang,Zhenxing He,Juhua Zhao,Wenming Xiao,Lingling Xiong
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The critical phases of effective research planning, scientific writing, and communication Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Pitchai Balakumar,BettadapuraN Srikumar,B Ramesh,Gowraganahalli Jagadeesh
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Exploring cross-linked tragacanth as novel excipient-proof-of-concept Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 AnroopB Nair,NRaghavendra Naveen,Santosh Fattepur,Prakash Goudanavar,NagaPrashant Koppuravuri,Buduru Gowthami,Mallikarjun Telsang,RiyazAli Osmani,Nagaraja Sreeharsha,Mohammed Habeebuddin
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Possible correction of thiazide-induced hypokalemia with co-administration of date palm fruits with hydrochlorothiazide in rats Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Mahesh Attimarad,PromiseMadu Emeka,KazeemYusuff Babatunde,AbdulazizK Al Mouslem
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Synthesis, characterization, and anti-hepatocellular carcinoma effect of glycyrrhizin-coupled bovine serum albumin-loaded luteolin nanoparticles Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Yongli Zhang,Yongxia Yang,Huaguo Liang,Pei Zeng,Wei Fu,Jingwei Yu,Luxi Chen,Dong Chai,Ying Wen,Ali Chen
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Anti-inflammatory, antioxidant, cytotoxic activities, and sesquiterpenoid contents of Paralemnalia thyrsoides Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 WaliedM Alarif,AyaAli Alassass,MarwaS Abubakr,Seif-EldinN Ayyad,Abd-ElsalamE Mohammed
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Network pharmacology analysis with molecular docking of phytochemicals of Panax ginseng against osteosarcoma Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 SongJa Kim,FahadHassan Shah
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Development and evaluation of sesamol-loaded self nanoemulsifying drug delivery system for breast cancer Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Poonam Kushwaha,Namrata Singh,Amresh Gupta,Akash Ved,Shivam Swarup
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Alteration of murine cytochrome P450 profiles in fatty liver disease by hesperidin and myricetin Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Kanokwan Jarukamjorn,Nadta Sukkasem,Waranya Chatuphonprasert
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Effect of total flavonoids of Hippophae rhamnoides L. on the activity and mRNA expression of CYP450 in rats Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Dong Zhang,Guodong Wu,Haimei Hao,Le Chang,Xiaofeng Cao
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Screening and characterization of an acid polysaccharide with antioxidant activity in vitro and in vivo from Dendrobium aurantiacum var. denneanum (Kerr) Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Aoxue Luo,Yijun Fan,Xueyan Tan,Juan Zhao,Kaigang Yang,Shengdi Wu,Jiao Zhang,Shangrao Pu,Gang Wang
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Phyto-mediated green synthesis of silver nanoparticles using Acmella oleracea leaf extract: Antioxidant and catalytic activity Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Rajni Garg,Sweta Bhardwaj,Suman Lata
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Evaluation of cardioprotective potential of isolated swerchirin against the isoproterenol-induced cardiotoxicity in wistar albino rats Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 SyedEhtaishamul Haque,Rustam Ekbbal,Ashif Iqubal,MohdAsif Ansari,Sayeed Ahmad
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Enhanced synergistic antitumor efficacy with topotecan (camptothecin derivative) and curcumin analogs coadministration in novel proniosomal formulations Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 AfzalHaq Asif,PredeepkumarNarayanappa Shiroorkar,Purna Singh,Pottathil Shinu,Nagaraja Sreeharsha,MdKhalid Anwer
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Anti-tick potential and intra-specific chemical variations in Ageratum conyzoides L. collected from Indus plain and Central India Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Sharad Srivastava,Bhanu Kumar,PushpendraKumar Shukla,AnilKumar Sharma,AjayKumar Singh Rawat,YashwantSingh Rawat,Srikant Ghosh
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The ethanol extract of Caragana sinica ameliorated skin lesions in mice with contact dermatitis Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Hyungwoo Kim,Seonkyung Jang,Yoonhyoung Kang,Yuntae Kang,Seungyeop Oh,Soyeon Kim,Ji-Hyo Lyu
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Anticancer effects of Piper nigrum extract against cholangiocarcinoma cells Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Benjaporn Buranrat,Laddawan Senggunprai,Auemduan Prawan,Veerapol Kukongviriyapan
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Protective effect of Lycium barbarum on renal injury induced by acute pancreatitis in rats Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Kadir Batcioglu,Tugba Dogan,ElifKayhan Kustepe,AyseBurcin Uyumlu,Yakup Yilmaztekin
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Structure identification and biological activities of a new polysaccharide isolated from Lyophyllum decastes (Fr.) Sing Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Yiling Hou,Xiang Ding,Ying Liu
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In vitro cytotoxic activity using fruits of Annona muricata and aerial parts of Euphorbia tirucalli against lung and oral cancer cell lines Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 RamachandraSiddamsetty Setty,B Swapna,MRaghavendra Rao,Satvik Kotha,S Sagar
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Polyherbal formulation improves glucose-lipid metabolism and prevent hepatotoxicity in streptozotocin-induced diabetic rats: Plausible role of IRS-PI3K-Akt-GLUT2 signaling Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Manju Sharma,Abdul Haye,MohdAsif Ansari,Abhinav Saini,Zubair Ahmed,Kavita Munjal,Yasmeen Shamsi
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Ocotillo-type ginsenosides from the Panax vietnamensis ha et grushv protect H9c2 cardiomyocytes against H2O2-induced apoptosis Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Wei-Wei Jiang,Jing Xie,Xiao-Bo Li,Chun-Hua Ma
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Rehmanniae Radix-Induced apoptosis via inhibition of PI3K/AKT/mTOR signaling pathways in human hepatocellular carcinoma cell lines SMMC-7721 Pharmacogn. Mag. (IF 0.7) Pub Date : 2022-01-01 Lin Cai,Bonian Liao,Fangli Luo,Shu Zhang,Zhengwan Deng
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Phytochemical investigation of bauhinia winitii based on alpha-glucosidase inhibitory effect and molecular docking affirmation Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Sukanya Dej-adisai, Ichwan Ridwan Rais, Chatchai Wattanapiromsakul, Thanet Pitakbut
Background: Bauhinia winitii (BW) (Fabaceae) plant revealed poor phytochemical investigation and anti-diabetic report. As one of the Bauhinia family which known with abundant flavonoids content, contrary, BW was only used for the treatment of diarrhea in Thai conservative remedy. Objectives: The aim of this study was to investigate the phytochemical constituents and anti-alpha glucosidase activity
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Effects of retinoic acid-induced osteoporosis on pharmacokinetics and tissue distribution of 2,3,5,4'-tetrahydroxy stilbene-2-Ο-β-D-glucoside and β-ecdysterone in rats Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Sun Yan-Tao, Wang Bing, Kang Ting-Guo
Background: The compatibility of Radix Polygoni multiflori-Achyranthes (RPMA) root is a Traditional Chinese medicine pair frequently used in the clinic and has good anti-osteoporosis (OP) effects. Materials and Methods: The extract of the compatibility of RPMA root was given orally in this study. The pharmacokinetics and the distribution in the tissues of tetrahydroxystilbene glucoside and β-ecdysterone
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Antifibrotic effects of lilii bulbus extract in a mouse model of bleomycin-induced pulmonary fibrosis Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Shuen-Cheng Chiang, Jihye Park, Jinhyun Bae, Hyejin Joo, Donghyun Lee, Kwan-Il Kim, Seok-Jae Ko, Jae-Woo Park, Youngmin Bu, Beom-Joon Lee
Objectives: Lilii Bulbus (LB), a lung-moistening herbal medicine, has been used to treat the symptoms of pulmonary fibrosis, including dry cough and dyspnea. In this study, we investigated whether LB water extract (LIB) has antifibrotic effects in a mouse model of bleomycin-induced pulmonary fibrosis. Materials and Methods: The effects of LIB and its mechanisms of action were investigated in a mouse
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Data mining and network pharmacology study on dried tangerine peel and immature tangerine peel essential oil as a treatment for liver depression and insomnia Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Gang Ke, Guilin Ren, Qingrong Pu, Rui Huang, Ting Liu, Lu Liu, Qian Gong, Jie Li, Rong Li
Background: With the variation of modern medical mode from “disease medicine” to “health medicine,” the traditional Chinese medicine (TCM) aromatherapy befits an important part of the exclusive health service resource intended for the prevention of diseases, rehabilitation and health care in China. Liver depression and insomnia are among the human health conditions that are apparently treated by TCMs
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Arbortristoside-A: A promising bioactive moiety from nyctanthes arbortristis linn. against hemorrhoid Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Sanjita Das, Saumya Das, Aniruddh Pratap Singh, Manas Kumar Das, Nishu Gautam, P Ayash Kumar, Sradhanjali Mohapatra, Richa Shakya
Background: Hemorrhoid disease is becoming a common problem in modernized society and its treatment is less developed. Although there are many plants used traditionally, proper scientific evidence is still lacking. Nyctanthes arbortristis Linn. is scientifically proved to have pharmacological activities. In this research work, an approach has been made to establish the potentiality of arbortristoside-A
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D-Pinitol-attenuated trinitrobenzene sulfonic acid-induced ulcerative colitis in experimental rats: possible through inhibition of nuclear factor-κb/nuclear factor of kappa light polypeptide gene enhancer in b-cell inhibitor-alpha pathway and activation of colonic tight junction proteins Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Hui Yang, Shanshan Yuan, Yongsheng Li
Background: Ulcerative colitis (UC) is a complex, chronic, and relapsing inflammatory disorder categorized by chronic inflammation followed by colonic damage. D-Pinitol has been recognized for its numerous pharmacological properties, counting antioxidant, antiulcer, and anti-inflammatory potential. Aim: The aim of the study was to measure the plausible mechanisms of action of pinitol on an experimental
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Systems bioinformatic approach to determine the pharmacological mechanisms of radix astragali and radix angelicae sinensis in idiopathic pulmonary fibrosis Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Yufeng Zhang, Lina Gu, Juan PuYang, Mengying Liu, Qingqing Xia, Weilong Jiang, Mengshu Cao
Background: Earlier meta-analysis has publicized that Radix Astragali (RA) and Radix Angelicae sinensis (RAS) are valuable to pulmonary function and exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Objectives: The objective of the study was to regulate the pharmacological mechanism of RA and RAS in IPF treatment. Materials and Methods: Microarray datasets for IPF were examined
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Gas chromatography coupled with mass analysis phytochemical profiling, antiproliferative and antimigratory effect of tagetes lucida leaves extracts on cervical cancer cell lines Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Onelio Mora-Candelario, Marco Antonio Leyva-Vázquez, Miguel Angel Mendoza-Catalán, Laura Álvarez, Mayra Antunez-Mojica, Julio Ortiz-Ortiz, Macdiel Acevedo-Quiroz
Background: Tagetes species have been extensively employed in folk medicine and have been demonstrated to exert various biological activities due to its phytochemical constituents, including those related to cancer. Objectives: The aim of this study was to identify, in Tagetes lucida organic leaf extracts, the bioactive compounds with antiproliferative and antimigratory activities on the human cervical
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Processed rehmanniae radix can improve cold syndrome damage of rats by regulating glycolipid metabolism Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Mengmeng Wang, Yingying Ke, Yangyang Wang, Tong Liu, Yage Li, Zengfu Shan, Wangyang Mi, Ning Zhou, Weisheng Feng, Xiaoke Zheng
Background: The traditional chinese medicine have medicinal property,and the property of the drug has been found to be mostly related to the body's substance and energy metabolism. Objectives: The present study intended to assess the drug property of Rehmanniae Radix Praeparata (PRR), called Shudihuang in traditional Chinese medicine and to discover its mechanism of cold syndrome in rats. Materials
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Beneficial effect of moringa stenopetala (bak.f) cuf. on lithium–pilocarpine-induced temporal lobe epilepsy in experimental animals Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Etsay Weldekidan Tsegay, Rajkapoor Balasubramanian, Kald Beshir Tuem, Abadi Kahsu Gebre
Background: Moringa stenopetala is traditionally used for the treatment of epilepsy in southern Ethiopia. Additionally, the plant material is used for the treatment of various ailments such as pain, diabetes, hypertension, and hyperlipemia. Aim of the Study: The aim of the study was to investigate the effect of M. stenopetala crude extract on the development of lithium–pilocarpine-induced temporal
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Optimization of steaming process for polysaccharides from panax notoginseng by box-behnken response surface methodology and comparison of immunomodulatory effects of raw and steamed panax notoginseng polysaccharides Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Na Xing, Zhihong Zhang, Donghui Peng, Yuxin Li, Xue Wang, Rui Wang, Yanshan He, Yuanning Zeng, Haixue Kuang, Qiuhong Wang
Aim: We aimed to optimize the steaming process of Pana notoginseng using response surface methodology (RSM). Materials and Methods: The yield and immune activity of steamed P. notoginseng polysaccharides (s-PNPs) was used as the indicators to optimize the steaming parameters: wetting time, steaming time, and temperature. After this, chromatogram and spectroscopy were used to analyze the effect of steaming
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Antischistosomal evaluation of stem bark's extract and chemical constituents from anonidium mannii against schistosoma mansoni Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Josette Linda Toussi Matchi, Diderot Tchamo Noungoue, Guilhem Chaubet, Jérôme Boissier, Isabelle Kuhn, Jean Claude Tchouankeu, Marc Nothisen, Sylvain Ursuegui, Silvère Augustin Ngouela, Alain Wagner
Context: Anonidium mannii (Annonaceae) has been traditionally used in Africa to treat stomach aches, schistosomiasis, and many other illnesses. However, few phytochemical study and no investigation on schistosomiasis have been conducted on this species. This neglected tropical disease, caused by a worm, comes second after malaria as the most devastating parasitical infection. Aim: The goal of this
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Species Difference of Asarinin Metabolism in vitro and its Effect on the Activity of Cytochrome P450 Enzymes Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Hu Tingting, Shi Xianbao, Jiayin Hu, Yang Jingming
Aim: To investigate the metabolic behaviors of asarinin in different species and found animal models with metabolic pathways similar to those in humans and to study the effect (inhibition or induction) between asarinin and cytochrome P450 enzymes (CYP450s). Materials and Methods: The interspecies difference in asarinin metabolism was studied using liver microsomes (LMs) from humans and six mammals
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Effects of cyclocarya paliurus flavonoid extract in non-alcoholic steatohepatitis mice: Intermeshing network pharmacology and in vivo pharmacological evaluation Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Senling Feng, Jing Zhang, Baoying Liang, Hongliu Jin, Zhongwen Yuan
Objectives: Non-alcoholic steatohepatitis (NASH) is the second most common cause of the hepatitis. In this study, we aimed to investigate the effects and mechanisms of Cyclocarya paliurus (CPF) flavonoids extract in the treatment of NASH. To achieve this, we performed compound target prediction and network analysis based on the method of network pharmacology. We investigated the effect of CPF extract
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Effect of aging and geographical variations in the content of guggulsterones and metabolomic profiling of oleogum resins of commiphora wightii: The Indian bdellium Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Rajesh Kumar Verma, Mohammad Ibrahim, Avi Fursule, Ranjan Mitra, Jatavallabhula Lakshmi Narayana Sastry, Sayeed Ahmad
Background: The oleo-gum resin of Commiphora wightii has been utilized for centuries in Ayurvedic medicine for the treatment of various diseases. Ruthless exploitation of this species with negligible conservation efforts has led to its inclusion in the International Union for Conservation of Nature assemblage of endangered plant species. Objectives: In this paper, the impact of plant aging and geographical
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Astragaloside iv inhibits salmonella-induced meningitis via modulation of bacterial virulence and host response Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Zhonghua Chen
Objectives: To control Salmonella-induced meningitis, in this study, we aimed to investigate the potential anti-virulence activity and neuroprotective role of astragaloside IV (AS-IV) under in vitro and ex vivo conditions during coculturing with Salmonella cells. Materials and Methods: The expression of virulence factors encoding genes was tested under in vitro conditions using quantitative real-time
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Cytotoxic and antitumor properties of ziziphus spina-christi found in al bahah region of hejaz area: An in vitro study on oral cancer cell lines Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Abdulaziz Al Shahrani, Jagadish Virupaxi Hosmani, Ibrahim AlShahrani, Rafi Ahmad Togoo, Tasneem Sakinatul Ain, Sadatullah Syed, Master Luqman Mannakandath, Mohamed Khaled Abdulrahman Addas
Background: Ziziphus spina-christi (Z s-c) is traditionally been used as an herbal medicine and is part of Rhamnaceae plants family. Objectives: The probable cytotoxic effect of Z s-c, found in Al Bahah region, on human oral cancer cell lines (SCC-9) was assessed in the present study. Materials and Methods: Bioactive compounds of Z s-c were evaluated using thin layer chromatography, analytical high-performance
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Chrysoeriol promotes functional neurological recovery in a rat model of cerebral ischemia Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Guoqiang Shao, Shenxu Chen, Yijie Sun, Haizhu Xu, Fangfang Ge
Background: Stroke is among the leading causes of death worldwide, but current treatment options for cerebral ischemia are limited. Chrysoeriol is a natural isolated agent with bioactive pharmacological properties. Materials and Methods: Sprague–Dawley rats were subjected to transient middle cerebral artery occlusion (MCAO) surgery and chrysoeriol was administrated for the subsequent 3 days. Neurological
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Comparison of Esophageal Mucosa Protective Efficacy of Evodiae Fructus and Toosendan Fructus against Duodenogastroesophageal Reflux Esophagitis Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Jin A Lee, Mi-Rae Shin, Hae-Jin Park, Seong-Soo Roh
Background: Gastroesophageal reflux disease accounts for more than 20% of the Western population and is a disease that is also increasing in incidence in Asian countries. Objectives: This work was aimed to assess the impact of Evodiae Fructus and Toosendan Fructus against esophageal mucosal injury with Duodenogastroesophageal Reflux Esophagitis (DGER). Materials and Methods: After inducing DGER through
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Hemidesmus indicus (l)-derived 2-hydroxy-4-methoxy benzoic acid attenuates dna damage and autophagy in sk-mel28 cells via p-erk pathway Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Yuanxin Miao, Zhenyu Chen, Zhiguo Wang, Chunnan Hu, Lu Chen, Hao Sun
Background: Melanoma, a type of skin cancer, is a leading cause of death worldwide. Currently available therapy shows numerous side effects; therefore, there is an urgent need to develop safe drugs to treat this malignancy. Recently, 2-hydroxy-4-methoxy benzoic acid (HMBA), a bioactive plant component, has been reported to demonstrate various biological functions. Objectives: In this study, the anticancer
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Myricitrin attenuates hypoxic-ischemia-induced brain injury in neonatal rats by mitigating oxidative stress and nuclear factor erythroid 2-related factor 2/hemeoxygenase-1/antioxidant response element signaling pathway Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Ting Yan, Man Lu
Background: Neonatal hypoxic ischemia (HI) is an overwhelming infantile neurological disability causing extreme morbidity and mortality with limited therapies available. Objectives: In this study, we aimed to explore the neuroprotective efficacy of myricitrin and elucidate the mechanism of action of myricitrin through the regulation of nuclear factor erythroid 2-related factor 2 (Nrf2)/hemeoxygenase-1
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Rhei rhizoma and citri pericarpium mixture regulates oxidative stress and tight junction proteins on acute reflux esophagitis Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Mi-Rae Shin, Jin A Lee, Min Ju Kim, Hae-Jin Park, Seong-Soo Roh
The aim of the present study was to assess the impact of a Rhei Rhizoma and Citri Pericarpium (RC) mixture on esophageal mucosal injury in rats with acute reflux esophagitis (ARE). An experimental model of ARE was established surgically. RC mixture was administered at a dose of 100 or 200 mg/kg body weight 90 min prior to induction of ARE, and its effects were compared with those of the Control group
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Antioxidant and antiglycation effects of cucurbita argyrosperma seeds polysaccharide Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Rosa Martha Perez Gutierrez
Background: Diabetes is related with oxidative stress caused by free radicals and glycation of the proteins. Objectives: This study aimed to isolate a polysaccharide (PLY) from Cucurbita argyrosperma seeds and determine their antioxidant and antiglycation effects. Materials and Methods: The PLY fraction was isolated by hot water extraction and purified by ion-exchange chromatography (A103S). La antioxidant
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Gas chromatography coupled with mass spectrometry for the rapid characterization and screening of volatile oil of euphorbia fischeriana steud Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Qi Liu, Yu-Mei Wang, Wen-Hao Fu, Ai-Hua Zhang
Gas chromatography (GC)-mass spectrometry is a powerful tool which is used in the analysis of volatile components in food and herbal medicine. Euphorbia fischeriana Steud., a traditional Chinese herb, has been used for thousands of years in China. Recently, scientists are exploring more on the pharmacological action of E. fischeriana. However, so far, there is no information regarding the volatile
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Anti-fatigue activities and phytochemical compositions of turnip (brassica rapa l.) extracts Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Yi Zhou, Zhanqiang Li
Background: Turnip (Brassica rapa L.) is a biennial plant, which belongs to Cruciferae Brassica, and is widely distributed at an altitude of 3000-4000 m in the Qinghai-Tibetan Plateau in western China. Turnip has been shown to have anti-hypoxia activities; however, there is limited scientific evidence of its anti-fatigue effects. Objectives: The objective is to evaluate the anti-fatigue properties
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Chemopreventive strategies of teucrium alopecurus de noé water insoluble fraction for hepatocarcinogenesis in lipopolysaccharide-induced mice models: Pharmacological attributes Pharmacogn. Mag. (IF 0.7) Pub Date : 2021-10-01 Fatma Guesmi, Manel Ben Ali, Ramla Ben Mouhoub, Amor Hedfi, Mohammad S AL-Harbi, Ahmed Landoulsi
Background: In Tunisia, the ethnobotanical study and biological activity of Teucrium alopecurus (TAlp), belonging to Labiatea family, is poorly recorded. Objectives: The goal of this study is to investigate the inhibitory potential of TAlp in lipopolysaccharide (LPS)-induced hepatic damage. Methods: Cell viability was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenylbromide (Thiazolyl blue tetrazolium