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Clinical and laboratory diagnosis of Mayaro virus (MAYV): Current status and opportunities for further development Rev. Med. Virol. (IF 11.1) Pub Date : 2024-03-18 Severino Jefferson Ribeiro da Silva, Larissa Krokovsky
The recent outbreaks related to Mayaro virus (MAYV) infection in the Americas have brought this neglected virus as a potential threat to global public health. Given the range of symptoms that can be associated with MAYV infection, it can be challenging to diagnose individuals based on clinical signs, especially in countries with simultaneous circulation of other mosquito-borne viruses, such as dengue
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Overview of reemerging mpox infection with a focus on neurological manifestations Rev. Med. Virol. (IF 11.1) Pub Date : 2024-03-08 Mohammed Alissa, Abdullah Alghamdi, Suad A. Alghamdi
Mpox, a reemerging zoonotic disease caused by the mpox virus, has garnered increasing attention due to its potential for severe clinical manifestations. While the cutaneous and systemic presentations of mpox have been well‐documented, its neurological complications have recently emerged as an area of concern. This review provides a brief overview of the neurological aspects of mpox infection, highlighting
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Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS‐CoV‐2 and other respiratory viruses: A comprehensive review Rev. Med. Virol. (IF 11.1) Pub Date : 2024-03-06 Chiranjib Chakraborty, Manojit Bhattacharya, Sang‐Soo Lee
miRNAs are single‐stranded ncRNAs that act as regulators of different human body processes. Several miRNAs have been noted to control the human immune and inflammatory response during severe acute respiratory infection syndrome (SARS‐CoV‐2) infection. Similarly, many miRNAs were upregulated and downregulated during different respiratory virus infections. Here, an attempt has been made to capture the
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Coinfections in human papillomavirus associated cancers and prophylactic recommendations Rev. Med. Virol. (IF 11.1) Pub Date : 2024-02-20 Gayathri Ashok, Soumya Basu, Priyamvada Priyamvada, Anand Anbarasu, Sreenivasulu Chintala, Sudha Ramaiah
The Human Papillomavirus (HPV) infection is responsible for more than 80% of reported cervical cancer and other virus‐associated tumours. Although this global threat can be controlled using effective vaccination strategies, a growing perturbation of HPV infection is an emerging coinfection likely to increase the severity of the infection in humans. Moreover, these coinfections prolong the HPV infections
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Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next? Rev. Med. Virol. (IF 11.1) Pub Date : 2024-02-20 Michael X. Fu, Peter Simmonds, Monique Andersson, Heli Harvala
Blood transfusion is a vital procedure, where transfusion‐transmitted infection of hepatitis B virus (HBV) remains an important issue, especially from blood donors with occult hepatitis B virus infection (OBI). Occult hepatitis B virus infection is a complex entity to detect using surrogate blood biomarkers for intrahepatic viral transcriptional activity, requiring a continually refined battery of
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Breakthrough infection and reinfection in patients with mpox Rev. Med. Virol. (IF 11.1) Pub Date : 2024-02-13 Wenyi Jiang, Yibo Hu, Xiu Yang, Lingli Hou, Jingjing Zhang, Hong Niu, Congxia Hu, Jihui Lin
Recently, patients with Mpox breakthrough infection or reinfection were constantly reported. However, the induction, risk factors, and important clinical symptoms of breakthrough infection and reinfection of Mpox virus (MPXV), as well as the factors affecting the effectiveness of Mpox vaccine are not characterized. Herein, a literature review was preformed to summarize the risk factors and important
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Clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands: A systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2024-02-10 Sahil Kharwadkar, Nipun Herath
Dengue, Zika and chikungunya outbreaks pose a significant public health risk to Pacific Island communities. Differential diagnosis is challenging due to overlapping clinical features and limited availability of laboratory diagnostic facilities. There is also insufficient information regarding the complications of these arboviruses, particularly for Zika and chikungunya. We conducted a systematic review
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Increased risk of new-onset cardiovascular disease after COVID-19: A systematic review and meta-analysis of 14 cohorts Rev. Med. Virol. (IF 11.1) Pub Date : 2024-02-01 Mingyao Sun, Mengyuan Yuan, Honghao Lai, Qian Wang, Hengyang Wang, Lina Xing, Jinhui Tian, Zhigang Zhang, Long Ge
Cardiovascular diseases (CVD) are common in long COVID, yet the associated risk remains uncertain. We aimed to quantify the risk of new-onset cardiovascular diseases after COVID-19. We searched PubMed, Embase, and Web of Science from inception up to October 2022. Cohort studies that provided information on the number, proportion, or relative risks (RR) of cardiovascular diseases after COVID-19 were
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Opportunities and challenges for the application of artificial intelligence paradigms into the management of endemic viral infections: The example of Chronic Hepatitis C Virus Rev. Med. Virol. (IF 11.1) Pub Date : 2024-02-02 Ahmed N. Farrag, Ahmed M. Kamel, Iman A. El-Baraky
Despite the advent of direct-acting antiviral agents (DAAs) as a definitive therapy for chronic hepatitis C virus (HCV) infection, the burden of the disease remains globally elevated. The emerging big data on different HCV paradigms fostered the introduction of artificial intelligence/machine learning (AI/ML) applications to help decrease that burden by providing more optimised strategies for early
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The relationship between HIV-1 neuroinflammation, neurocognitive impairment and encephalitis pathology: A systematic review of studies investigating post-mortem brain tissue Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-27 Monray Edward Williams, Petrus J. W. Naudé
The activities of HIV-1 in the central nervous system (CNS) are responsible for a dysregulated neuroinflammatory response and the subsequent development of HIV-associated neurocognitive disorders (HAND). The use of post-mortem human brain tissue is pivotal for studying the neuroimmune mechanisms of CNS HIV infection. To date, numerous studies have investigated HIV-1-induced neuroinflammation in post-mortem
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Human-virus protein-protein interactions maps assist in revealing the pathogenesis of viral infection Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-25 Hui-Min Chen, Jia-Xin Liu, Di Liu, Ge-Fei Hao, Guang-Fu Yang
Many significant viral infections have been recorded in human history, which have caused enormous negative impacts worldwide. Human-virus protein-protein interactions (PPIs) mediate viral infection and immune processes in the host. The identification, quantification, localization, and construction of human-virus PPIs maps are critical prerequisites for understanding the biophysical basis of the viral
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Immunogenicity, clinical efficacy and safety of additional second COVID-19 booster vaccines against Omicron and its subvariants: A systematic review Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-24 Santenna Chenchula, Madhu Bhargavi Chandra, Madhu Babu Adusumilli, Sai Nikhila Ghanta, Anusha Bommasani, Anitha Kuttiappan, R. Padmavathi, Krishna Chaitanya Amerneni, Radhika Chikatipalli, Mohan Krishna Ghanta, Samarra Simha Reddy, K. Mythili Bai, Satya Prakash, G. Jogender, Madhavrao Chavan, S. Balakrishnan
The Omicron variant of severe acute respiratory syndrome coronavirus 2 is a new variant of concern (VOC) and an emerging subvariant that exhibits heightened infectivity, transmissibility, and immune evasion, escalating the incidence of moderate to severe coronavirus disease 2019 (COVID-19). It resists monoclonal antibodies and diminishes vaccine efficacy. Notably, new sublineages have outpaced earlier
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A comprehensive review of Langya virus and framework for future zoonotic disease control Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-22 Dang Huu Thien, Hoang Bao Tran, Nguyen Ngoc Phuong Uyen, Huynh Lai Phuong Thao, Huynh Thi My Tam, Nguyen Khoi Quan, Nguyen Tien Huy
First reported in August 2022, the Langya virus (LayV) has emerged as a potential global health threat in the post-COVID-19 era. Preliminary reports show that 35 patients near Shandong and Henan, China experienced a febrile acute LayV infection. We conducted this review following the PRISMA protocol to synthesise current knowledge on LayV's characteristics in terms of molecular, clinical, and public
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An overview of SARS-CoV2 natural infections in companion animals: A systematic review of the current evidence Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-08 Zahra Heydarifard, Ardalan Maleki Chegeni, Fatemeh Heydarifard, Bahram Nikmanesh, Vahid Salimi
This systematic review provides a comprehensive overview of natural SARS-CoV-2 infections in companion animals. The findings show that these infections are relatively rare. Among the examined dogs, only 1.32% tested positive for SARS-CoV-2, while for cats, the rate was 1.55%. Infections in rabbits and ferrets were even less common, at less than 1%. These results support previous research indicating
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The controversy of SARS-CoV-2 integration into the human genome Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-09 Laith AL-Eitan, Ahmad Mihyar
Bat borne disease have attracted many researchers for years. The ability of the bat to host several exogenous viruses has been a focal point in research lately. The latest pandemic shifted the focus of scholars towards understanding the difference in response to viral infection between humans and bats. In a way to understand the basis of the interaction and behaviour between SARS-CoV-2 and the environment
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Utilising biosensor-based approaches for identifying neurotropic viruses Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-09 Mohammed Alissa, Ahmed Hjazi
Neurotropic viruses, with their ability to invade the central nervous system, present a significant public health challenge, causing a spectrum of neurological diseases. Clinical manifestations of neurotropic viral infections vary widely, from mild to life-threatening conditions, such as HSV-induced encephalitis or poliovirus-induced poliomyelitis. Traditional diagnostic methods, including polymerase
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Assessment of the relationship between the dopaminergic pathway and severe acute respiratory syndrome coronavirus 2 infection, with related neuropathological features, and potential therapeutic approaches in COVID-19 infection Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-05 Yousef Rasmi, Ameneh Shokati, Shima Hatamkhani, Yeganeh Farnamian, Roya Naderi, Ladan Jalali
Dopamine is a known catecholamine neurotransmitter involved in several physiological processes, including motor control, motivation, reward, cognition, and immune function. Dopamine receptors are widely distributed throughout the nervous system and in immune cells. Several viruses, including human immunodeficiency virus and Japanese encephalitis virus, can use dopaminergic receptors to replicate in
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Virus-induced host cell metabolic alteration Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-05 Syed Shahariar Bappy, Md. Muzammal Haque Asim, Mohammad Mainul Ahasan, Asif Ahsan, Sorna Sultana, Roksana Khanam, Abu Zaffar Shibly, Yearul Kabir
Viruses change the host cell metabolism to produce infectious particles and create optimal conditions for replication and reproduction. Numerous host cell pathways have been modified to ensure available biomolecules and sufficient energy. Metabolomics studies conducted over the past decade have revealed that eukaryotic viruses alter the metabolism of their host cells on a large scale. Modifying pathways
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The impact of trained immunity in respiratory viral infections Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-05 Jocelyne Piret, Guy Boivin
Epidemic peaks of respiratory viruses that co-circulate during the winter-spring seasons can be synchronous or asynchronous. The occurrence of temporal patterns in epidemics caused by some respiratory viruses suggests that they could negatively interact with each other. These negative interactions may result from a programme of innate immune memory, known as trained immunity, which may confer broad
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Prevalence and outcomes of upper gastrointestinal bleeding in COVID-19: A systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-04 Sawai Singh Rathore, Zario Shai Wint, Aman Goyal, Bijay Mukesh Jeswani, Ameer Mustafa Farrukh, María Alejandra Nieto-Salazar, Thanmai Reddy Thugu, Snigdha Erva, Raafay Mehmood, Adriana Carolina Toro-velandia, Hamam Aneis, Sunny Ratnani, Ibrahim Marouf Yasin Al Shyyab
Upper gastrointestinal bleeding (UGIB) in COVID-19 presents challenges in patient management. Existing studies lack comprehensive review due to varied designs, samples, and demographics. A meta-analysis can provide valuable insights into the incidence, features, and outcomes of UGIB in COVID-19. A comprehensive literature search was carried out using several databases. We considered all appropriate
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Estimates of congenital cytomegalovirus-attributable infant mortality in high-income countries: A review Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-03 Scott D. Grosse, Patrick Fleming, Megan H. Pesch, William D. Rawlinson
As many as 5%–10% of infants with symptomatic congenital cytomegalovirus (cCMV) disease, or 0.4%–0.8% of all liveborn infants with cCMV infection, die in early infancy in high-income countries. However, estimates are uncertain due to several potential biases that can result from data limitations and study designs. First, infants with cCMV infections who die prior to diagnosis, which usually occurs
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Clinical characteristics and outcomes of patients with mpox during the 2022 mpox outbreak compared with those before the outbreak: A systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2024-01-01 Wonyoung Cho, Sangil Park, Hyeon Jin Kim, Myeongcheol Lee, Yong Sung Choi, Seung Geun Yeo, Jinseok Lee, Ai Koyanagi, Louis Jacob, Lee Smith, Masoud Rahmati, Suhana Ahmad, Guillaume Fond, Laurent Boyer, Sang Youl Rhee, Seung Won Lee, Jae Il Shin, Ho Geol Woo, Dong Keon Yon
On 23 July 2022, the World Health Organization declared the global mpox outbreak as a public health emergency of international significance. The mpox virus (MPXV) that caused the outbreak was classified as clade IIb, which belongs to the West African clade. However, the relationship between MPXV clades and symptoms, as well as the severity of mpox outcomes, is not fully understood. Thus, we aimed to
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Safety and efficacy of COVID-19 vaccines: A systematic review and meta-analysis of controlled and randomized clinical trials Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-29 Jayesh Beladiya, Anup Kumar, Yogesh Vasava, Krupanshu Parmar, Dipanshi Patel, Sandip Patel, Sandip Dholakia, Devang Sheth, Sai H. S. Boddu, Chirag Patel
Vaccines against coronavirus disease 2019 (COVID-19) have been discovered within a very small duration of time as compared to the traditional way for the development of vaccines, which raised the question about the safety and efficacy of the approved vaccines. The purpose of this study is to look at the effectiveness and safety of vaccine platforms against the incidence of COVID-19. The literature
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Targeting the mammalian target of rapamycin pathway in neurological manifestations of Covid-19 Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-29 Han Wang, Li Cheng, Lanlan Yu, Zhigang Guo
The diverse and severe nature of neurological manifestations associated with coronavirus disease 2019 (Covid-19) has garnered increasing attention. Exploring the potential to decrease neurological complications in Covid-19 patients involves targeting the mammalian target of rapamycin (mTOR) pathway as a therapeutic strategy. The mTOR pathway, widely recognised for its central role in essential cellular
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Issue Information Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-27
No abstract is available for this article.
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Relationship of human cytomegalovirus-infected endothelial cells and circulating leukocytes in the pathogenesis of disseminated human cytomegalovirus infection: A narrative review Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-28 Giuseppe Gerna, Daniele Lilleri, Chiara Fornara, Piera d’Angelo, Fausto Baldanti
Among the leucocyte subpopulations circulating in peripheral blood of immune-compromised patients with disseminated Human cytomegalovirus (HCMV) infection, polymorphonuclear leuckocytes (PMNL) and M/M may carry infectious virus. While only in PMNL early HCMV replicative events do occur, monocytes are susceptible to complete virus replication when they enter human organs, where as macrophages become
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Evaluating fluvoxamine for the outpatient treatment of COVID-19: A systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-26 Jiawen Deng, Myron Moskalyk, Qi Kang Zuo, Cristian Garcia, Umaima Abbas, Harikrishnaa Ba Ramaraju, Daniel Rayner, Ye-Jean Park, Kiyan Heybati, Fangwen Zhou, Simran Lohit
This systematic review and meta-analysis of randomised controlled trials (RCTs) aimed to evaluate the efficacy, safety, and tolerability of fluvoxamine for the outpatient management of COVID-19. We conducted this review in accordance with the PRISMA 2020 guidelines. Literature searches were conducted in MEDLINE, EMBASE, International Pharmaceutical Abstracts, CINAHL, Web of Science, and CENTRAL up
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Cumulative incidence and mortality rate of cardiovascular complications due to laboratory-confirmed influenza virus infection: A systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-21 Konstantinos Ouranos, Stephanos Vassilopoulos, Athanasios Vassilopoulos, Fadi Shehadeh, Eleftherios Mylonakis
Influenza infection is associated with cardiovascular complications that range significantly in presentation and severity. The cumulative incidence of cardiovascular complications due to laboratory-confirmed influenza, however, is not reported in the literature. We conducted a systematic review and random-effects meta-analysis to evaluate the cumulative incidence and mortality rate of influenza virus-related
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Targeting epidermal growth factor receptor signalling pathway: A promising therapeutic option for COVID-19 Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-21 Aroona Razzaq, Cyrollah Disoma, Yuzheng Zhou, Siyi Tao, Zongpeng Chen, Sixu Liu, Rong Zheng, Yongxing Zhang, Yujie Liao, Xuan Chen, Sijie Liu, Zijun Dong, Liangtao Xu, Xu Deng, Shanni Li, Zanxian Xia
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously producing new variants, necessitating effective therapeutics. Patients are not only confronted by the immediate symptoms of infection but also by the long-term health issues linked to long COVID-19. Activation of epidermal growth factor receptor (EGFR) signalling during SARS-CoV-2 infection promotes virus propagation,
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Assessing the antiviral potential of melatonin: A comprehensive systematic review Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-21 Tasneem Alomari, Haneen Al-Abdallat, Rawan Hamamreh, Omar Alomari, Beria H. Hos, Russel J. Reiter
This review assesses the antiviral potential of melatonin through comprehensive analysis of studies across human subjects, animal models, cell cultures, and in-silico simulations. The search strategy targeted relevant research until 22 June 2023, resulting in 20 primary studies after screening and deduplication. The findings highlight strong evidence supporting antiviral properties of melatonin. In
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Virus-like particles as powerful vaccination strategy against human viruses Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-20 Ikbel Hadj Hassine, Manel Ben M'hadheb, Mohammed A. Almalki, Jawhar Gharbi
Nowadays, viruses are not only seen as causative agents of viral infectious diseases but also as valuable research materials for various biomedical purposes, including recombinant protein production. When expressed in living or cell-free expression systems, viral structural proteins self-assemble into virus-like particles (VLPs). Mimicking the native form and size of viruses and lacking the genetic
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Role of the VEGF in virus-associated cancers Rev. Med. Virol. (IF 11.1) Pub Date : 2023-12-11 Shaian Tavakolian, Seidamir Pasha Tabaeian, Abolfazl Namazi, Ebrahim Faghihloo, Abolfazl Akbari
The role of numerous risk factors, including consumption of alcohol, smoking, having diet high in fat and sugar and many other items, on caner progression cannot be denied. Viral diseases are one these factors, and they can initiate some signalling pathways causing cancer. For example, they can be effective on providing oxygen and nutrients by inducing VEGF expression. In this review article, we summarised
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Serological response and immune-related adverse events following COVID-19 vaccination in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-28 Yue Wang, Dong Chen, Yuancan Pan, Haiming Li, Weizhe Zhao, Taicheng Lu, Weijia Kong, Min Ding, Xiaomin Wang, Ganlin Zhang
With the popularity of Coronavirus disease 2019 (COVID-19) vaccine and the development of vaccination strategies, the impact of COVID-19 vaccine on cancer patients receiving immune checkpoint inhibitors (ICIs) is still unclear. In the systematic review and meta-analysis of patients with ICIs, we assessed the serological response of cancer patients receiving COVID-19 vaccine, and explored the risk of
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The association between various viral infections and multiple sclerosis: An umbrella review on systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-27 Arash Bakhshi, Narges Eslami, Naeim Norouzi, Negin Letafatkar, Ehsan Amini-Salehi, Soheil Hassanipour
Multiple Sclerosis (MS) is one of the immune-mediated demyelinating disorders. Multiple components, including the environment and genetics, are possible factors in the pathogenesis of MS. Also, it can be said that infections are a key component of the host's response to MS development. Finally, we evaluated the relationship between different pathogens and MS disease in this umbrella research. We systematically
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Comparable performance of antigen-detecting rapid test by healthcare worker-collected and self-collected swabs for SARS-CoV-2 diagnostic: A systematic review and meta-analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-21 Samuel Johnson Kurniawan, Maria Mardalena Martini Kaisar, Helen Kristin, Soegianto Ali
Usage of self-screening tests has become increasingly relevant in public health perspective for early detection of SARS-CoV-2 infection in the transitioning era of the COVID-19 pandemic into an endemic. This study was designed to compare the diagnostic accuracy of self-conducted and health professional-conducted SARS-CoV-2 rapid antigen tests (Ag-RDTs) and whether the sample was taken from anterior
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Immunopathology of herpes simplex virus-associated neuroinflammation: Unveiling the mysteries Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-20 Md Sadique Hussain, Gaurav Gupta, Vijaya Paul Samuel, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Shakir Saleem, Ruqaiyah Khan, Najla Altwaijry, Samir Patel, Archita Patel, Sachin Kumar Singh, Kamal Dua
The immunopathology of herpes simplex virus (HSV)-associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes
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Reply to Kleebayoon and Wiwanitkit on 'Effects of COVID-19 vaccination during pregnancy on SARS-CoV-2 infection and maternal and neonatal outcomes: A systematic review and meta-analysis'. Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-17 Masoud Rahmati,Dong Keon Yon,Seung Won Lee,Laurie Butler,Ai Koyanagi,Louis Jacob,Jae Il Shin,Lee Smith
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The 2022 monkeypox outbreak 1 year on: The 5 Ws Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-06 Gulfaraz Khan, Nighat Perveen
In May 2022, World Health Organization (WHO) reported an outbreak of Mpox in several European countries which were previously Mpox free. Mpox (formerly known as monkeypox) is a zoonotic viral disease endemic in Central and West Africa. The sudden emergence of Mpox outside Africa and its subsequent rapid spread lead the WHO to declare the outbreak as Public Health Emergency of International Concern
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Issue Information Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-03
No abstract is available for this article.
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Histomolecular characterisation of hepatitis B virus induced liver cancer Rev. Med. Virol. (IF 11.1) Pub Date : 2023-10-30 Adane Adugna
Hepatitis B virus (HBV)-associated liver cancer is the third most prevalent cancer-related cause of death worldwide. Different studies have been done on the histomolecular analysis of HBV induced-liver cancer including epigenetics which are dynamic molecular mechanisms to control gene expression without altering the host deoxyribonucleic acid, genomics characterise the integration of the viral genome
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Genomic and biological variation in bat IFNs: An antiviral treatment approach Rev. Med. Virol. (IF 11.1) Pub Date : 2023-11-03 Laith AL-Eitan, Ahmad Mihyar, Liguo Zhang, Punam Bisht, Rudolf Jaenisch
Bat-borne viruses have attracted considerable research, especially in relation to the Covid-19 pandemic. Although bats can carry multiple zoonotic viruses that are lethal to many mammalian species, they appear to be asymptomatic to viral infection despite the high viral loads contained in their bodies. There are several differences between bats and other mammals. One of the major differences between
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Targeting EBV-encoded products: Implications for drug development in EBV-associated diseases Rev. Med. Virol. (IF 11.1) Pub Date : 2023-10-31 Mengwen Lv, Yuan Ding, Yan Zhang, Shuzhen Liu
Epstein-Barr virus, a human gamma-herpesvirus, has a close connection to the pathogenesis of cancers and other diseases, which are a burden for public health worldwide. So far, several drugs or biomolecules have been discovered that can target EBV-encoded products for treatment, such as Silvestrol, affinity toxin, roscovitine, H20, H31, curcumin, thymoquinone, and ribosomal protein L22. These drugs
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The programed death-1/programed death ligand-1 axis and its potential as a therapeutic target for virus-associated tumours Rev. Med. Virol. (IF 11.1) Pub Date : 2023-10-31 Jing Li, Yan Zhang, Bing Luo
As an important and serious condition impacting human health, the diagnosis, and treatment of tumours is clinically vital because tumour cell immune escape sustains tumour development. Programed death ligand-1 (PD-L1) on tumour cell surfaces binds to the programed death-1 (PD-1), inhibits T cell activation, and induces apoptosis, and incapacitates cells. This allows tumour cells to evade recognition
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Electroencephalographic findings post-COVID-19 vaccination: A systematic review of case reports and case series Rev. Med. Virol. (IF 11.1) Pub Date : 2023-10-09 Asra Fazlollahi, Mahdi Zahmatyar, Ali Shamekh, Alireza Motamedi, Fatemeh Seyedi, Homa Seyedmirzaei, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Mark J. M. Sullman, Ali-Asghar Kolahi, Shahnam Arshi, Saeid Safiri
A number of different neurological complications have been reported following vaccination against the coronavirus disease 2019 (COVID-19). Electroencephalogram (EEG) is one of the modalities used to evaluate the neurological complications of diseases. The aim of the present study was to identify the EEG changes in participants vaccinated against COVID-19. PubMed, Scopus, Web of Science, medRxiv, and
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COVID-19 in hematopoietic stem-cell transplant recipients: A systematic review and meta-analysis of clinical characteristics and outcomes Rev. Med. Virol. (IF 11.1) Pub Date : 2023-10-04 Bruno Azevedo Randi, Hermes Ryoiti Higashino, Vinícius Ponzio da Silva, Erick Menezes Xavier, Vanderson Rocha, Silvia Figueiredo Costa
Patients who undergo hematopoietic stem-cell transplantation (HSCT) are more susceptible to developing severe forms of COVID-19 with an increased risk of mortality. The aim of this study was to analyze, by performing a systematic review and meta-analysis, all studies that evaluated COVID-19 in HSCT adult recipients and present clinical characteristics and outcomes. Studies were eligible for inclusion
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Modulation of various host cellular machinery during COVID-19 infection Rev. Med. Virol. (IF 11.1) Pub Date : 2023-09-27 Shivani Malvankar, Anjali Singh, Y. S. Ravi Kumar, Swetangini Sahu, Megha Shah, Yamini Murghai, Mahendra Seervi, Rupesh K. Srivastava, Bhupendra Verma
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) emerged in December 2019, causing a range of respiratory infections from mild to severe. This resulted in the ongoing global COVID-19 pandemic, which has had a significant impact on public health. The World Health Organization declared COVID-19 as a global pandemic in March 2020. Viruses are intracellular pathogens that rely on the host's
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Human bocavirus respiratory infection: Tracing the path from viral replication and virus-cell interactions to diagnostic methods Rev. Med. Virol. (IF 11.1) Pub Date : 2023-09-25 María Belén Colazo Salbetti, Gabriel Amilcar Boggio, Laura Moreno, María Pilar Adamo
Human bocaviruses were first described between 2005 and 2010, identified in respiratory and enteric tract samples of children. Screening studies have shown worldwide distribution. Based on phylogenetic analysis, they were classified into four genotypes (HBoV1-4). From a clinical perspective, human bocavirus 1 (HBoV1) is considered the most relevant, since it can cause upper and lower acute respiratory
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Lactate dehydrogenase contribution to symptom persistence in long COVID: A pooled analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-09-14 Raphael Udeh, Alberto Utrero-Rico, Xenia Dolja-Gore, Masoud Rahmati, Mark McEVoy, Tony Kenna
There's critical need for risk predictors in long COVID. This meta-analysis evaluates the evidence for an association between plasma lactate dehydrogenase (LDH) and long COVID and explores the contribution of LDH to symptoms persistent across the distinct post-acute sequelae of COVID-19 (PASC) domains. PubMed, EMBASE, Web of Science, and Google Scholar were searched for articles published up to 20
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Human immunodeficiency virus transmission—Mechanisms underlying the cell-to-cell spread of human immunodeficiency virus Rev. Med. Virol. (IF 11.1) Pub Date : 2023-09-12 Marta Calado, David Pires, Carolina Conceição, Quirina Santos-Costa, Elsa Anes, José Miguel Azevedo-Pereira
Despite the success of combined antiretroviral therapy in controlling viral load and reducing the risk of human immunodeficiency virus (HIV) transmission, an estimated 1.5 million new infections occurred worldwide in 2021. These new infections are mainly the result of sexual intercourse and thus involve cells present on the genital mucosa, such as dendritic cells (DCs), macrophages (Mø) and CD4+ T
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Issue Information Rev. Med. Virol. (IF 11.1) Pub Date : 2023-09-07
No abstract is available for this article.
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The knowns and unknowns of cardiac autoimmunity in viral myocarditis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-09-02 Kiruthiga Mone, Jay Reddy
Myocarditis can result from various infectious and non-infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate infectious viral particles during clinical presentations, partly because by that point, the viruses would have damaged the tissues and be cleared by the
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Impact of differentiated service delivery models on retention in HIV care and viral suppression among people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis of randomised controlled trials Rev. Med. Virol. (IF 11.1) Pub Date : 2023-09-01 George M. Bwire, Belinda J. Njiro, Harieth P. Ndumwa, Castory G. Munishi, Bonaventura C. Mpondo, Mathew Mganga, Emmanuel Mang'ombe, Muhammad Bakari, Raphael Z. Sangeda, Christopher R. Sudfeld, Japthet Killewo
Differentiated service delivery (DSD) models, such as adherence clubs (ACs), are client-centred approaches where clinically stable people living with HIV (PLHIV) meet to receive various services, including psychosocial support, brief symptoms screening, and refills of antiretroviral medications, among others. We conducted a review to assess the impact of DSD models, including ACs, on sustaining retention
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Dynamics of viral disease outbreaks: A hundred years (1918/19–2019/20) in retrospect - Loses, lessons and emerging issues Rev. Med. Virol. (IF 11.1) Pub Date : 2023-08-21 Nicholas I. Nii-Trebi, Thomas S. Mughogho, Anisa Abdulai, Francis Tetteh, Priscilla M. Ofosu, Mary-Magdalene Osei, Akua K. Yalley
Infectious diseases continue to be the leading cause of morbidity and mortality, and a formidable obstacle to the development and well-being of people worldwide. Viruses account for more than half of infectious disease outbreaks that have plagued the world. The past century (1918/19–2019/20) has witnessed some of the worst viral disease outbreaks the world has recorded, with overwhelming impact especially
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Appraisal of evidence reliability and applicability of Paxlovid as treatment for SARS-COV-2 infection: A systematic review Rev. Med. Virol. (IF 11.1) Pub Date : 2023-08-14 Chang-tai Zhu, Jian-Yun Yin, Xiao-hua Chen, Ming Liu, Shi-gui Yang
This study aimed to clarify the beneficial effect and the clinical application value of Paxlovid in the treatment of coronavirus disease-19 (COVID-19) through a systematic review. Databases including PubMed, Cochrane Library, Chinese Clinical Trial Registry, and ClinicalTrials.gov were systematically searched for interventional or observational studies on the efficacy and safety of Paxlovid in the
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Prospects for developing an Hepatitis C virus E1E2-based nanoparticle vaccine Rev. Med. Virol. (IF 11.1) Pub Date : 2023-08-11 Eric A. Toth, Alexander K. Andrianov, Thomas R. Fuerst
Globally, more than 58 million people are chronically infected with Hepatitis C virus (HCV) with 1.5 million new infections occurring each year. An effective vaccine for HCV is therefore a major unmet medical and public health need. Since HCV rapidly accumulates mutations, vaccines must elicit the production of broadly neutralising antibodies (bnAbs) in a reproducible fashion. Decades of research have
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SARS-CoV-2 in digital era: Diagnostic techniques and importance of nucleic acid quantification with digital PCRs Rev. Med. Virol. (IF 11.1) Pub Date : 2023-08-02 N. Aravind Kumar, S. Aradhana, Harleen, M. R. Vishnuraj
Studies related to clinical diagnosis and research of SARS-CoV-2 are important in the current pandemic era. Although molecular biology has emphasised the importance of qualitative analysis, quantitative analysis with nucleic acids in relation to SARS-CoV-2 needs to be clearly emphasised, which can provide perspective for viral dynamic studies of SARS-CoV-2. In this regard, the requirement and utilization
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A meta-analysis and mapping of global mpox infection among children and adolescents Rev. Med. Virol. (IF 11.1) Pub Date : 2023-08-02 Tarun Kumar Suvvari, Mokanpally Sandeep, Jogender Kumar, Prakasini Satapathy, Santenna Chenchula, Aravind P. Gandhi, Muhammad Aaqib Shamim, Patricia Schlagenhauf, Alfonso J. Rodríguez-Morales, Ranjit Sah, Keerti Bhusan Pradhan, Sarvesh Rustagi, Alaa Hamza Hermis, Bijaya K. Padhi
Monkeypox (mpox) is a significant health concern affecting children and adolescents globally. This systematic review and meta-analysis aims to synthesise the available evidence on the proportion of children and adolescents affected by the mpox virus. A comprehensive search was conducted in seven electronic databases (PubMed, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane) to identify
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Efficacy and safety of paxlovid (nirmatrelvir/ritonavir) in the treatment of COVID-19: An updated meta-analysis and trial sequential analysis Rev. Med. Virol. (IF 11.1) Pub Date : 2023-07-23 Haokun Tian, Changsen Yang, Tiangang Song, Kechen Zhou, Lequan Wen, Ye Tian, Lirui Tang, Weikai Xu, Xinyuan Zhang
Our study is aimed to access the efficacy and safety outcomes for coronavirus disease 2019 (COVID-19) patients treated with Paxlovid. According to inclusion and exclusion criteria, databases were used to retrieve articles from 1 January 2020 to 1 January 2023. Article screening, quality evaluation and data extraction were completed and cross-checked. The meta-analysis and trial sequential analysis
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Issue Information Rev. Med. Virol. (IF 11.1) Pub Date : 2023-07-07
No abstract is available for this article.
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Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture Rev. Med. Virol. (IF 11.1) Pub Date : 2023-07-01 Gabriele Chiffi, Denis Grandgirard, Stephen L. Leib, Aleš Chrdle, Daniel Růžek
Tick-borne encephalitis virus (TBEV) is a flavivirus commonly found in at least 27 European and Asian countries. It is an emerging public health problem, with steadily increasing case numbers over recent decades. Tick-borne encephalitis virus affects between 10,000 and 15,000 patients annually. Infection occurs through the bite of an infected tick and, much less commonly, through infected milk consumption