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  • The two faces of Coprinus comatus—Functional properties and potential hazards
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-27
    Patryk Nowakowski; Sylwia K. Naliwajko; Renata Markiewicz‐Żukowska; Maria H. Borawska; Katarzyna Socha

    Mushrooms have been used for centuries not only as food but also in traditional medicine as a source of components with pro‐health activity. One of them is Coprinus comatus (O.F.Müll.) Pers. also called shaggy mane, chicken drumstick mushroom, or lawyer's wig. In Asian countries, C . comatus (CC) is approved as edible mushroom and often cultivated for consumption, whereas in many other countries, although

  • Protective effects of isorhamnetin on pulmonary arterial hypertension: in vivo and in vitro studies
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-25
    Zhi Chang; Jia‐ling Wang; Zhi‐cheng Jing; Ping Ma; Qing‐bing Xu; Jian‐rong Na; Jie Tian; Xuan Ma; Wei Zhou; Ru Zhou

    Pulmonary arterial hypertension (PAH) is a malignant disease with high mortality and closely involves the bone morphogenetic protein (BMP) pathway. Mutations in BMPR2 caused proliferation of pulmonary artery smooth muscle cells (PASMCs) leading to PAH. Isorhamnetin, one of the main naturally occurring flavonoids extracted from Hippophae rhamnoides L , shows antiinflammatory and anti‐proliferative properties

  • Anticancer molecular mechanisms of oleocanthal.
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-24
    Mohammed El Haouari,Juan E Quintero,Juan A Rosado

    Cancer is among the leading causes of mortality worldwide. Current cancer therapies are associated with serious side effects, which further damage patients' health. Therefore, the search for new anticancer agents with no toxic effects on normal and healthy cells is of great interest. Recently, we and other groups have demonstrated that oleocanthal (OLC), a phenolic compound from extra virgin olive

  • Effect of evening primrose oil supplementation on lipid profile: A systematic review and meta-analysis of randomized clinical trials.
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-22
    Masoud Khorshidi,Meysam Zarezadeh,Omid Moradi Moghaddam,Mohammad Reza Emami,Hamed Kord-Varkaneh,Seyed Mohammad Mousavi,Shahab Alizadeh,Javad Heshmati,Beheshteh Olang,Naheed Aryaeian

    BACKGROUND Studies have shown that evening primrose oil (EPO) supplementation might be effective in improving lipid profile, however, the results are inconsistent. This study was performed to determine the direction and magnitude of the EPO effect on the lipid profile. METHODS PubMed, Scopus, Cochrane Library, Embase and Web of Science databases and Google Scholar were searched up to September-2019

  • Clinical trials on pain lowering effect of ginger: A narrative review.
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-20
    Mariangela Rondanelli,Federica Fossari,Viviana Vecchio,Clara Gasparri,Gabriella Peroni,Daniele Spadaccini,Antonella Riva,Giovanna Petrangolini,Giancarlo Iannello,Mara Nichetti,Vittoria Infantino,Simone Perna

    Ginger has a pain-reducing effect and it can modulate pain through various mechanisms: inhibition of prostaglandins via the COX and LOX-pathways, antioxidant activity, inibition of the transcription factor nf-kB, or acting as agonist of vanilloid nociceptor. This narrative review summarizes the last 10-year of randomized controlled trials (RCTs), in which ginger was traditionally used as a pain reliever

  • Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of Tinospora crispa.
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-19
    Ahmed Rakib,Shahriar Ahmed,Md Ashiqul Islam,Mir Muhammad Nasir Uddin,Arkajyoti Paul,Md Nazim Uddin Chy,Talha Bin Emran,Veronique Seidel

    Pharmacological studies were performed in mice on the methanol extract of Tinospora crispa (TC), and of its hexane (HF) and chloroform (CF) fractions. Significant antinociceptive activity was observed for TC, HF, and CF in the acetic acid-induced writhing and formalin-induced paw licking tests. Anxiolytic and antidepressant activities were assessed using the open field, hole board, and elevated plus

  • Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress.
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-19
    Chunyang Yi,Xiaolong Li,Si Chen,Mingyao Liu,Weiqiang Lu,Xiyun Ye

    Natural product corynoline is a unique isoquinoline alkaloid extracted from traditional Chinese medicine Corydalis bungeana Turcz, whereas its anticancer properties have not been investigated. In this study, we found that corynoline potently impairs the growth of melanoma cells, B16F10, and A375 in a concentration-dependent manner. Treatment of melanoma cells with corynoline results in G2 cell arrest

  • Dammarane sapogenins attenuates stress-induced anxiety-like behaviors by upregulating ERK/CREB/BDNF pathways.
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-19
    Ning Jiang,Haixia Wang,Jingwei Lv,Qiong Wang,Cong Lu,Yujiao Li,Xinmin Liu

    Dammarane sapogenins (DS), an extract derived from ginseng by alkaline hydrolysis of total ginsenosides, possesses high pharmacological activity and higher bioavailability than ginsenosides. The present study was designed to investigate the anxiolytic-like effects of DS in a mouse model of chronic social defeat stress (CSDS). DS (40 and 80 mg/kg) significantly ameliorated social avoidance and anxiety-like

  • Potential effects of curcumin in the treatment of COVID-19 infection.
    Phytother. Res. (IF 3.766) Pub Date : 2020-05-19
    Fatemeh Zahedipour,Seyede Atefe Hosseini,Thozhukat Sathyapalan,Muhammed Majeed,Tannaz Jamialahmadi,Khalid Al-Rasadi,Maciej Banach,Amirhossein Sahebkar

    Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus