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Erucin, a natural isothiocyanate, exerts pro‐angiogenic properties in cultured endothelial cells and reverts angiogenic impairment induced by high glucose Phytother. Res. (IF 7.2) Pub Date : 2024-03-16 Shirley Genah, Valerio Ciccone, Arianna Filippelli, Vittoria Simonis, Alma Martelli, Eugenia Piragine, Eleonora Pagnotta, Nicola Pecchioni, Vincenzo Calderone, Lucia Morbidelli
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Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia Phytother. Res. (IF 7.2) Pub Date : 2024-03-16 Wenfang Lai, Rui Luo, Yuheng Tang, Zhengshuang Yu, Binbin Zhou, Zelin Yang, John Brown, Guizhu Hong
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Kaempferitrin attenuates unilateral ureteral obstruction‐induced renal inflammation and fibrosis in mice by inhibiting NOX4‐mediated tubular ferroptosis Phytother. Res. (IF 7.2) Pub Date : 2024-03-15 Jianchun Li, Jieke Yang, Qianwen Xian, Hongwei Su, Yufang Ni, Li Wang
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Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside Phytother. Res. (IF 7.2) Pub Date : 2024-03-13 Jhong Yuan Chen, Tsung Rung Huang, Shih Yun Hsu, Ching Chun Huang, Huei Syun Wang, Jung San Chang
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Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose–response meta‐analysis Phytother. Res. (IF 7.2) Pub Date : 2024-03-13 Shooka Mohammadi, Damoon Ashtary‐Larky, Omid Asbaghi, Vida Farrokhi, Yasaman Jadidi, Fatemeh Mofidi, Mehrnaz Mohammadian, Reza Afrisham
It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review and dose–response meta‐analysis assessed the impact of SIL administration on certain hepatic, renal, and oxidative stress markers. A systematic search was conducted in various databases to identify relevant trials published until January 2023. Randomized controlled
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Effect of hesperidin on blood pressure and lipid profile: A systematic review and meta‐analysis of randomized controlled trials Phytother. Res. (IF 7.2) Pub Date : 2024-03-11 Hanumanthappa Shylaja, Gollapalle Lakshminarayanashastry Viswanatha, Venkategowda Sunil, Shalam M. Hussain, Syeda Ayesha Farhana
The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta‐analysis published on this topic in 2019. However, considering the recently published clinical studies, there is a scope for performing a systematic review and meta‐analysis of hesperidin to determine its beneficial effect in alleviating alterations in cardiovascular parameters
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Dihydrocapsaicin suppresses the STING‐mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia–reperfusion injury of perforator skin flap Phytother. Res. (IF 7.2) Pub Date : 2024-03-09 Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Gao
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Quercetin inhibits necroptosis in cardiomyocytes after ischemia–reperfusion via DNA-PKcs-SIRT5-orchestrated mitochondrial quality control Phytother. Res. (IF 7.2) Pub Date : 2024-03-06 Xing Chang, Qin Zhang, Yu Huang, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Zhiming Liu, Ruxiu Liu
We investigated the mechanism by which quercetin preserves mitochondrial quality control (MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme-linked immunosorbent assay was employed in the in vivo experiments to assess myocardial injury markers, measure the transcript levels of SIRT5/DNAPK-cs/MLKL during various time intervals of ischemia–reperfusion, and observe structural changes
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Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation Phytother. Res. (IF 7.2) Pub Date : 2024-03-07 Daifan Yue, Dongming Zheng, Yuxin Bai, Linlan Yang, Jiangyan Yong, Yan Li
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Therapeutic potential of saffron in brain disorders: From bench to bedside Phytother. Res. (IF 7.2) Pub Date : 2024-03-06 Erjola Bej, Anna Rita Volpe, Patrizia Cesare, Annamaria Cimini, Michele d'Angelo, Vanessa Castelli
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Curculigoside, a traditional Chinese medicine monomer, ameliorates oxidative stress in Alzheimer's disease mouse model via suppressing ferroptosis Phytother. Res. (IF 7.2) Pub Date : 2024-03-06 Yuhang Gong, Yanan Wang, Yanfeng Li, Fanglin Weng, Tong Chen, Ling He
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Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review Phytother. Res. (IF 7.2) Pub Date : 2024-03-03 Sepideh Yadegar, Fatemeh Mohammadi, Amirhossein Yadegar, Ali Mohammadi Naeini, Aryan Ayati, Nesa Milan, Amirhossein Tayebi, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani
Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible
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Targeting epidermal growth factor receptor and its downstream signaling pathways by natural products: A mechanistic insight Phytother. Res. (IF 7.2) Pub Date : 2024-03-04 Rutuja Damare, Kritika Engle, Gautam Kumar
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Exploring the therapeutic potential of quercetin: A focus on its sirtuin‐mediated benefits Phytother. Res. (IF 7.2) Pub Date : 2024-03-02 Anca Ungurianu, Anca Zanfirescu, Denisa Margină
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Natural H2S‐donors: A new pharmacological opportunity for the management of overweight and obesity Phytother. Res. (IF 7.2) Pub Date : 2024-03-02 Jacopo Spezzini, Eugenia Piragine, Lorenzo Flori, Vincenzo Calderone, Alma Martelli
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New horizons for the study of saffron (Crocus sativus L.) and its active ingredients in the management of neurological and psychiatric disorders: A systematic review of clinical evidence and mechanisms Phytother. Res. (IF 7.2) Pub Date : 2024-03-01 Shufen Han, Yifei Cao, Xingrong Wu, Jiaoyang Xu, Zizheng Nie, Yue Qiu
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Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review Phytother. Res. (IF 7.2) Pub Date : 2024-02-29 Sale Zhang, Farzam Kiarasi
Recently, various studies have shown that epigenetic changes are associated with aging and age‐related diseases. Both animal and human models have revealed that epigenetic processes are involved in aging mechanisms. These processes happen at multiple levels and include histone modification, DNA methylation, and changes in noncoding RNA expression. Consequently, changes in the organization of chromatin
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Long COVID‐19 gastrointestinal related disorders and traditional Chinese medicine: A network target‐based approach Phytother. Res. (IF 7.2) Pub Date : 2024-02-29 Laura Beatrice Mattioli, Maria Frosini, Ivan Corazza, Sirio Fiorino, Maddalena Zippi, Matteo Micucci, Roberta Budriesi
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Impact of Chinese herbal medicine on sarcopenia in enhancing muscle mass, strength, and function: A systematic review and meta‐analysis of randomized controlled trials Phytother. Res. (IF 7.2) Pub Date : 2024-02-29 Yujie Zhang, Kaoqiang Liu, Yunfan Zhan, Ye Zhao, Yongli Chai, Jiawei Ning, Hui Pan, Lingjun Kong, Wei'an Yuan
Sarcopenia has become important to the public health with the increase in the aging population in society. However, the therapeutic effects of conventional approaches, including pharmacotherapy, exercise, and nutritional intervention, are far from satisfactory. Chinese herbal medicine is a new treatment format with interesting possibilities in sarcopenia has been widely practiced. The study aims to
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Comprehensive review of Bcl-2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small molecules Phytother. Res. (IF 7.2) Pub Date : 2024-02-28 Iksen, Wasita Witayateeraporn, Besse Hardianti, Varisa Pongrakhananon
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Carnosol alleviates sepsis‐induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2‐related factor 2/sirtuin‐3 signaling pathway to attenuate oxidative damage Phytother. Res. (IF 7.2) Pub Date : 2024-02-28 Xingbing Li, Shuo Wang, Minghao Luo, Ming Wang, Shaoping Wu, Chang Liu, Fengxian Wang, Yong Li
Excessive reactive oxygen species production during acute lung injury (ALI) will aggravate the inflammatory process and endothelial barrier dysfunction. Carnosol is a natural phenolic diterpene with antioxidant and anti‐inflammatory properties, but its role in treating sepsis‐induced ALI remains unclear. This study aims to explore the protective effects and underlying mechanisms of carnosol in sepsis‐induced
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Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention Phytother. Res. (IF 7.2) Pub Date : 2024-02-28 Mehedi Hasan Bappi, Md. Nayem Mia, Siddique Akber Ansari, Irfan Aamer Ansari, Abdullah Al Shamsh Prottay, Md. Showkoth Akbor, Heba A. S. El‐Nashar, Mohamed El‐Shazly, Mohammad S. Mubarak, Muhammad Torequl Islam
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The effects of pomegranate consumption on blood pressure in adults: A systematic review and meta‐analysis Phytother. Res. (IF 7.2) Pub Date : 2024-02-27 Hossein Bahari, Kosar Omidian, Kian Goudarzi, Hossein Rafiei, Omid Asbaghi, Kosar Sadat Hosseini Kolbadi, Moslem Naderian, Ali Hosseini
Considering the main component of cardiovascular disease and due to the high prevalence of hypertension, controlling blood pressure is required in individuals with various health conditions. Randomized clinical trials (RCTs) which studied the effects of pomegranate consumption on blood pressure have shown inconsistent findings. As a result, we intended to assess the effects of pomegranate consumption
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Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K/AKT pathway Phytother. Res. (IF 7.2) Pub Date : 2024-02-27 Hong Wu, Tianjun Ma, Mei He, Wenkai Xie, Xueyan Wang, Liuping Lu, Hui Wang, Ying Cui
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Therapeutic effects and molecular mechanisms of natural products in thrombosis Phytother. Res. (IF 7.2) Pub Date : 2024-02-24 Ming‐hao Yuan, Wen‐xiao Zhong, Yu‐lu Wang, Yu‐shi Liu, Jia‐wen Song, Yu‐rou Guo, Bin Zeng, Yi‐ping Guo, Li Guo
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The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity Phytother. Res. (IF 7.2) Pub Date : 2024-02-24 Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
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Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy Phytother. Res. (IF 7.2) Pub Date : 2024-02-23 Yiping Zhang, Jun Xie
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Effect of proanthocyanidins on blood lipids: A systematic review and meta‐analysis Phytother. Res. (IF 7.2) Pub Date : 2024-02-23 Peng Wang, Xue Lian Liu, Zong Zhe Jiang, Yang Long, Chen Lin Gao, Wei Huang, Xiao Zhen Tan, Xiu Mei Ma, Yong Xu
Proanthocyanidins (PCs) are natural antioxidant polyphenols and their effect on the regulation of blood lipids is still controversial. This study was conducted to evaluate the effect of PCs on lipid metabolism. We searched PubMed, Embase, Web of Science, Chinese biomedical literature service system, China National Knowledge Internet, and Wanfang Data with no time restriction until March 18, 2022, using
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Asiaticoside ameliorates DSS‐induced colitis in mice by inhibiting inflammatory response, protecting intestinal barrier and regulating intestinal microecology Phytother. Res. (IF 7.2) Pub Date : 2024-02-22 Kunjian Liu, Yu Yin, Chong Shi, Chengqiu Yan, Yiwen Zhang, Li Qiu, Shuangyan He, Guofeng Li
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Critical review on anti‐inflammation effects of saponins and their molecular mechanisms Phytother. Res. (IF 7.2) Pub Date : 2024-02-19 Tharuka Wijesekara, Jinhai Luo, Baojun Xu
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Quercetin as a promising intervention for rat osteoarthritis by decreasing M1‐polarized macrophages via blocking the TRPV1‐mediated P2X7/NLRP3 signaling pathway Phytother. Res. (IF 7.2) Pub Date : 2024-02-19 Wenjun Li, Hebei He, Min Du, Mu Gao, Qijie Sun, Yeyang Wang, Hanyu Lu, Shuanji Ou, Changliang Xia, Changpeng Xu, Qi Zhao, Hongtao Sun
Osteoarthritis (OA) is characterized by an imbalance between M1 and M2 polarized synovial macrophages. Quercetin has shown protective effects against OA by altering M1/M2‐polarized macrophages, but the underlying mechanisms remain unclear. In this study, rat chondrocytes were treated with 10 ng/mL of IL‐1β. To create M1‐polarized macrophages in vitro, rat bone marrow‐derived macrophages (rBMDMs) were
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Natural xanthones as modulators of the Nrf2/ARE signaling pathway and potential gastroprotective agents Phytother. Res. (IF 7.2) Pub Date : 2024-02-19 Natalie Vivien Gunter, Soek Sin Teh, Ibrahim Jantan, Kung Pui Law, Hiroyuki Morita, Siau Hui Mah
Oxidative stress is implicated in the initiation, pathogenesis, and progression of various gastric inflammatory diseases (GID). The prevalence of these diseases remains a concern along with the increasing risks of adverse effects in current clinical interventions. Hence, new gastroprotective agents capable of inhibiting oxidative stress by modulating cellular defense systems such as the nuclear factor
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Anti-inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review Phytother. Res. (IF 7.2) Pub Date : 2024-02-15 Farzaneh Shakeri, Sahar Kiani, Golnoosh Rahimi, Mohammad Hossein Boskabady
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The anti-inflammatory activity of flavonoids and alkaloids from Sophora flavescens alleviates psoriasiform lesions: Prenylation and methoxylation beneficially enhance bioactivity and skin targeting Phytother. Res. (IF 7.2) Pub Date : 2024-02-15 Chwan-Fwu Lin, Ming-Hsien Lin, Chi-Feng Hung, Abdullah Alshetaili, Yung-Fong Tsai, Cai-Ling Jhong, Jia-You Fang
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Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoA Phytother. Res. (IF 7.2) Pub Date : 2024-02-15 Jiahui Zhang, Tao Jiang, Yuxin Zhang, Kai Yang, Yichen Zhao, Qi Zhou, Zhuo Yang, Renhao Yang, Ruonan Ning, Tao Liu, Lianfu Deng, Xiaobing Xi, Xing Xu, Min Jiang
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Herb-drug interactions: A short review on central and peripheral nervous system drugs Phytother. Res. (IF 7.2) Pub Date : 2024-02-15 João Bernardo, Patrícia Valentão
Herbal medicines are widely perceived as natural and safe remedies. However, their concomitant use with prescribed drugs is a common practice, often undertaken without full awareness of the potential risks and frequently without medical supervision. This practice introduces a tangible risk of herb-drug interactions, which can manifest as a spectrum of consequences, ranging from acute, self-limited
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Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update Phytother. Res. (IF 7.2) Pub Date : 2024-02-15 Dusanka Kitic, Bojana Miladinovic, Milica Randjelovic, Agnieszka Szopa, Veronique Seidel, Parteek Prasher, Mousmee Sharma, Rabab Fatima, Dilek Arslan Ateşşahin, Daniela Calina, Javad Sharifi-Rad
Morinda citrifolia L., commonly known as Noni, has a longstanding history in traditional medicine for treating various diseases. Recently, there has been an increased focus on exploring Noni extracts and phytoconstituents, particularly for their effectiveness against cancers such as lung, esophageal, liver, and breast cancer, and their potential in cancer chemoprevention. This study aims to provide
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Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy-induced bone loss Phytother. Res. (IF 7.2) Pub Date : 2024-02-15 Yansi Xian, Yijie Gao, Yiji Su, Yuangang Su, Haoyu Lian, Xiaoliang Feng, Zhijuan Liu, Jinmin Zhao, Jiake Xu, Qian Liu, Fangming Song
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Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy Phytother. Res. (IF 7.2) Pub Date : 2024-02-14 Bethsebie Lalduhsaki Sailo, Suravi Chauhan, Mangala Hegde, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Arul Goel, Gautam Sethi, Ajaikumar B. Kunnumakkara
Chemoresistance is the adaptation of cancer cells against therapeutic agents. When exhibited by cancer cells, chemoresistance helps them to avoid apoptosis, cause relapse, and metastasize, making it challenging for chemotherapeutic agents to treat cancer. Various strategies like dosage modification of drugs, nanoparticle-based delivery of chemotherapeutics, antibody-drug conjugates, and so on are being
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Unravelling the role of Silibinin in targeting CD44+ cancer stem cells: Therapeutic implications, effective strategies and approaches Phytother. Res. (IF 7.2) Pub Date : 2024-02-14 Shreya Lotia, Shanaya Patel, Aditi Patel, Vaishnavi Patel, Kanisha Shah, Vivek Tanavde
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Regulation of mitophagy and mitochondrial function: Natural compounds as potential therapeutic strategies for Parkinson's disease Phytother. Res. (IF 7.2) Pub Date : 2024-02-14 Hao Liang, Zhenwang Ma, Wei Zhong, Jia Liu, Kazuo Sugimoto, Hong Chen
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Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo Phytother. Res. (IF 7.2) Pub Date : 2024-02-13 Ya-li Ren, Jie-ting Lei, Ting-rui Zhang, Peng Lu, Dan-dan Cui, Bo Yang, Gui-ying Zhao, Fu Peng, Zhi-xing Cao, Cheng Peng, Yu-zhi Li
Triple-negative breast cancer (TNBC) is the most aggressive and lethal clinical subtype and lacks effective targeted therapies at present. Isobavachalcone (IBC), the main active component of Psoralea corylifolia L., has potential anticancer effects. Herein, we identified IBC as a natural sirtuin 2 (SIRT2) inhibitor and characterized the potential mechanisms underlying the inhibition of TNBC. Molecular
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Cover Image Phytother. Res. (IF 7.2) Pub Date : 2024-02-13 Lan Lu, Jingya Wang, Chongrui Wang, Jie Zhu, Hongping Wang, Li Liao, Yuting Zhao, Xiaobo Wang, Chen Yang, Zhengyou He, Mingxing Li
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Correction to “Stigmasterol regulates microglial M1/M2 polarization via the TLR4/NF-κB pathway to alleviate neuropathic pain” Phytother. Res. (IF 7.2) Pub Date : 2024-02-09
Si, W., Li, X., Jing, B., Chang, S., Zheng, Y., Chen, Z., Zhao, G., & Zhang, D. (2024). Stigmasterol regulates microglial M1/M2 polarization via the TLR4/NF-κB pathway to alleviate neuropathic pain Phytotherapy Research,38(1), 265–279. https://doi.org/10.1002/ptr.8039 The author would like to correct Figures 1(d) and 2(a), (e), and (f). The images of the Sham group in Figure 1(d) and the images of
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Futoquinol improves Aβ25–35-induced memory impairment in mice by inhibiting the activation of p38MAPK through the glycolysis pathway and regulating the composition of the gut microbiota Phytother. Res. (IF 7.2) Pub Date : 2024-02-08 Yuhan Zhang, Hui Chen, Mengnan Zeng, Pengli Guo, Meng Liu, Bing Cao, Ru Wang, Fengxiao Hao, Xiaoke Zheng, Weisheng Feng
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Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination Phytother. Res. (IF 7.2) Pub Date : 2024-02-07 Liuye Yang, Meng Du, Kaiyuan Liu, Pengchao Wang, Jingbo Zhu, Fengcen Li, Ze Wang, Kai Huang, Minglu Liang
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Correction to Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase Phytother. Res. (IF 7.2) Pub Date : 2024-02-06
Liu L, Zhang Y, Wang L, Liu Y, Chen H, Hu Q, Xie C, Meng X, and Shen X. Phytother Res. 2023; 37(10): 4587–4606. https://onlinelibrary.wiley.com/doi/10.1002/ptr.7928 The authors would like to correct the Western blotting band errors in Figure 3o and the raw data of Western blot bands of GAPDH in Figure 5a, due to an inadvertent error caused while saving the data. The corrected figures are provided below
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Phyto-therapeutic potential of Withania somnifera: Molecular mechanism and health implications Phytother. Res. (IF 7.2) Pub Date : 2024-02-06 Nisha Yadav, Sandhya Tripathi, Neelam S. Sangwan
Withania somnifera, the plant named Indian ginseng, Ashwagandha, or winter cherry, has been used since ancient times to cure various health ailments. Withania somnifera is rich in constituents belonging to chemical classes like alkaloids, saponins, flavonoids, phenolic acids, and withanolides. Several chemotypes were identified based on their phytochemical composition and credited for their multiple
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Correction to: Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling Phytother. Res. (IF 7.2) Pub Date : 2024-02-05 Na Yang, Chunpeng Zou, Wu Luo, Diyun Xu, Mengyang Wang, Yi Wang, Gaojun Wu, Peiren Shan, Guang Liang
Corrected article in Phytotherapy Research, Volume 37, Issue 2 The authors regret that two original images (the whole-heart image of the Ang II-Pump+Scl 5 mg/kg group in Figure 1e and the H&E staining image of the Ctrl group in Figure 1H) in this manuscript have been misused. The correct version of Figure 1 including the replaced images in Figure 1e,h is listed below. The authors confirm that the corrections
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D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway Phytother. Res. (IF 7.2) Pub Date : 2024-02-04 Xiaoli Li, Xin Yu, Fei Yu, Chunli Fu, Wenqian Zhao, Xiaosong Liu, Chaochao Dai, Haiqing Gao, Mei Cheng, Baoying Li
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Saponins as therapeutic candidates for atherosclerosis Phytother. Res. (IF 7.2) Pub Date : 2024-02-01 Nuan Lv, Luming Wang, Miao Zeng, Yijing Wang, Bin Yu, Wenyun Zeng, Xijuan Jiang, Yanrong Suo
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Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives Phytother. Res. (IF 7.2) Pub Date : 2024-02-01 Yuan Chen, Xiyue Tan, Wenwen Zhang, Yubing Li, Xinyu Deng, Jinhao Zeng, Lihua Huang, Xiao Ma
Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer-related mortality, continues to pose significant challenges in the realm of medical oncology, impacting both clinical drug selection and mechanistic research. Recent investigations have unveiled autophagy-related signaling as a promising avenue for HCC treatment. A growing body of research has highlighted the pivotal
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Efficacy of an oral suspension containing xyloglucan and pea proteins on a murine model of gastroesophageal reflux disease Phytother. Res. (IF 7.2) Pub Date : 2024-01-31 Alessio Ardizzone, Deborah Mannino, Giovanna Casili, Michela Campolo, Irene Paterniti, Marika Lanza, Alessia Filippone, Alberto Repici, Valentina Bova, Anna Paola Capra, Salvatore Cuzzocrea, Emanuela Esposito
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Flavonoids derived from medicinal plants as a COVID-19 treatment Phytother. Res. (IF 7.2) Pub Date : 2024-01-29 Mentor Sopjani, Francesca Falco, Federica Impellitteri, Valeria Guarrasi, Xuan Nguyen Thi, Miribane Dërmaku-Sopjani, Caterina Faggio
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 disease. Through its viral spike (S) protein, the virus enters and infects epithelial cells by utilizing angiotensin-converting enzyme 2 as a host cell's receptor protein. The COVID-19 pandemic had a profound impact on global public health and economies. Although various effective vaccinations and medications are now available
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Tanshinone IIA reverses gefitinib resistance in EGFR-mutant lung cancer via inhibition of SREBP1-mediated lipogenesis Phytother. Res. (IF 7.2) Pub Date : 2024-01-28 Lei Zhang, Chuncao Xu, Junyuan Huang, Shiqin Jiang, Zhiyan Qin, Lin Cao, Guoyao Tan, Zhongxiang Zhao, Min Huang, Jing Jin
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Mitochondrial-targeted curcumin inhibits T-cell activation via Nrf2 and inhibits graft-versus-host-disease in a mouse model Phytother. Res. (IF 7.2) Pub Date : 2024-01-28 Raghavendra S. Patwardhan, Dievya Gohil, Babita Singh, Binita K. Kumar, Vaitashi Purohit, Maikho Thoh, Rahul Checker, Nilesh Gardi, Vikram Gota, Vijay Kumar Kutala, Sejal Patwardhan, Deepak Sharma, Santosh K. Sandur
Anti-inflammatory and immune suppressive agents are required to moderate hyper-activation of lymphocytes under disease conditions or organ transplantation. However, selective disruption of mitochondrial redox has not been evaluated as a therapeutic strategy for suppression of T-cell-mediated pathologies. Using mitochondrial targeted curcumin (MitoC), we studied the effect of mitochondrial redox modulation
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Plant-derived compounds as potential leads for new drug development targeting COVID-19 Phytother. Res. (IF 7.2) Pub Date : 2024-01-28 Lingxiu Liu, Maxim Kapralov, Mark Ashton
COVID-19, which was first identified in 2019 in Wuhan, China, is a respiratory illness caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although some patients infected with COVID-19 can remain asymptomatic, most experience a range of symptoms that can be mild to severe. Common symptoms include fever, cough, shortness of breath, fatigue, loss of taste or smell and
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Effects of purified anthocyanins supplementation on serum concentration of inflammatory mediators: A systematic review and dose–response meta-analysis on randomized clinical trials Phytother. Res. (IF 7.2) Pub Date : 2024-01-25 Mitra Hariri, Bahareh Amirkalali, Ali Gholami
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Gum acacia dietary fiber: Significance in immunomodulation, inflammatory diseases, and cancer Phytother. Res. (IF 7.2) Pub Date : 2024-01-25 Srikanth Barkeer, Ramesh Pothuraju, Pushkar Malakar, Tatiana Colombo Pimentel, Jawed A. Siddiqui, S. Asha Nair