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Development of a novel human stratum corneum mimetic phospholipid vesicle-based permeation assay models for in vitro permeation studies Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-18 Yuerong Qian, Xuchao Wei, Yiwei Wang, Shaoping Yin, Jun Chen, Jie Dong
Objectives: Development and evaluation of a novel human stratum corneum (SC) mimetic phospholipid vesicle-based permeation assay (PVPASC) model for in vitro permeation studies. Significance: Due Ow...
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Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-14 Gustavo Ferrari, Loise Silveira da Silva, Renata Cerruti, Izabelle de Mello Gindri, Gean Vitor Salmoria, Carlos Rodrigo de Mello Roesler
The overactive bladder is a condition characterized by a sudden urge to urinate, even with small volumes of urine present in the bladder. The current treatments available for this pathology consist...
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Construction and in vitro/in vivo evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-14 Hongfei Liu, Ying Bao, Xiangping Lai, Yingshu Feng, Dan Yang, Rui Sun, Caleb Kesse Firempong, Haibing He
The purpose of the present study was to formulate a menantine hydrochloride (MH) sustained-release suspension.Menantine hydrochloride drug resin complex (MH-DRC) was prepared with strong acid catio...
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BSA nanoclusters-based sensor for detection of dopamine in schizophrenia from biofluids Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-12 Bhakti Khanolkar, Pravin Shende
Development of non-toxic and stable fluorescent emission B-Cu nanoclusters (NCs) for the specific detection of dopamine at low concentrations in cerebrospinal fluid (CSF).Fluorescent gold and coppe...
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Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-11 Huiyun Zhang, Yu zhang, Yunfei Hu, Shunru Wei, Michael Adu-Frimpong, Congyong Sun, Gang Qi
Objective Magnolol (MG) and Brucea javanica (L.) Merr. oil (BJO) possess synergetic anti-tumor effects, but have poor water solubility and stability, which results in low oral bioavailability. Sign...
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A newly developed UPLC-MS/MS method for simultaneous quantitative analysis of ajuforrestin A, ajuforrestin B, ajugamacrin and 8-O-Acetylharpagide derived from Ajuga Plants in mice blood and the in vivo pharmacokinetics Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-08 Xiuwei Shen, Chen Chen, Congcong Wen, Shuaishuai Yu, Huamin Liu, Xiaomin Gao, Lianguo Chen
Objective: To develop a sensitive and fast detection method via ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to assess the concentration of ajuforrestin A, ajuforre...
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Exposure to Potentially Harmful Excipients in Medications among Neonates at a State Hospital in Malaysia Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-08 Shien Woan Wong, Soo Piing Chew, Siti Azdiah AbdulAziz, Noraida MohamedShah
Objectives: This study aimed to determine the incidence, types and predictors of Potentially Harmful Excipients (PHE) exposure among hospitalized neonates.Methods: A prospective observational study...
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Formulation and optimisation of Ozenoxacin topical nano-emulgel including a comprehensive methodology to qualify and validate the critical parameters of an in-vitro release test method and ex-vivo permeation test Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-08 Amarnath Reddy Ramireddy, Dilip Kumar Behara
Objective: The purpose of this study was to formulate, optimise Ozenoxacin topical nano-emulsion using factorial design followed by to prepare and evaluate nano-emulgel using validated In-Vitro Rel...
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Computer-aided optimization of carbidopa/levodopa orally disintegrating tablets Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-08 Fucheng Qin, Congcong Wan, Yuanyuan Zhang
Objective: This study aimed to optimize the formulation of carbidopa/levodopa orally disintegrating tablets (ODTs) in order to improve their disintegration performance, and facilitate easier medica...
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Development, optimization and characterization of cisplatin loaded cubosomes for human lung carcinoma Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-03-07 Hassaan Umar, Habibah A Wahab, Nadeem Ahmed, Nao Akusa Fujimura, Muhammad Wahab Amjad, Syed Nasir Abbas Bukhari, Waqas Ahmad
ObjectivesThis study aimed to develop, optimize and evaluate glyceryl monooleate (GMO) based cubosomes as a drug delivery system containing cisplatin for treatment of human lung carcinoma.Significa...
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Combined eutexia and amorphization for simultaneous enhancement of dissolution rate of triamterene and hydrochlorothiazide: Preparation of orodispersible tablets Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-24 Hend A. Awad, Mohamed I. Fetouh, Amal A. Sultan, Gamal M. ElMaghraby
Background: Triamterene is an oral antihypertensive drug with dissolution-limited poor bioavailability. It can be used as monotherapy or in fixed dose combination with hydrochlorothiazide which als...
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Enhanced dissolution rates of glibenclamide through solid dispersions on microcrystalline cellulose and mannitol, combined with phosphatidylcholine Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-22 Wanlop Weecharangsan, Robert J. Lee
This study aimed to investigate the impact of physical solid dispersions of spray-dried glibenclamide (SG) on the surface of microcrystalline cellulose (MC) and mannitol (M) surfaces, as well as th...
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Developing a rapid analytical method for simultaneous determination of apigenin and gallic acid: validation and application in a nanoliposomal formulation Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-19 Ahmed Gouda, Omar S. Sakr, Maha Nasr, Omaima A. Sammour
Apigenin and gallic acid are natural compounds that are useful as antioxidant, anti-inflammatory and anticancer agents, especially when used together in combination. Therefore, the development and ...
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An empirical predictive model for determining the aqueous solubility of BCS class IV drugs in amorphous solid dispersions Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-14 Sridivya Raparla, Charina Lampa, Xiaoling Li, Bhaskara R Jasti
Determining solubility of drugs is laborious and time-consuming process that may not yield meaningful results. Amorphous solid dispersion (ASD) is a widely used solubility enhancement technique. Pr...
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Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-09 Nima Hamzian, Abolfazl Nickfarjam, Ali Shams, Fatemeh Haghiralsadat, Moslem Najmi-Nezhad
The present study aimed to assess the radioprotective effect of nanoniosomes loaded by Mentha Pulegium essential oil (MPEO-N nanoparticles) as a natural antioxidant on human peripheral blood mononu...
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Formulation, Optimization and Full Characterization of Mirtazapine Loaded Aquasomes: A new technique to boost antidepressant effects Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-09 Lamiaa Mohamed Hussein Ali, Aya Mohamed Dawaba, Shereen Ahmed El-Adawy
ObjectiveThe development of Mirtazapine (MRT)-loaded aquasomes by co-precipitation sonication technique to boost the antidepressant potential of MRT.MethodologyMRT-loaded aquasomes formulations wer...
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Development of PU Foam Dressings Loaded with Extract of Plectranthus Amboinicus for Burn Wound Healing Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-05 Akhila Jain, Sindhu Abraham, Shwetha Krishnamurthy, Kesha Desai, Basavaraj Basappa Veerabhadraiah
To develop Plectranthus amboinicus extract loaded Polyurethane foam dressing for burn wound healing.Plectranthus amboinicus is traditionally used as an anti-inflammatory and wound healing agent. It...
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Development and optimization of Clitoria Teratea synthesized silver nanoparticles and its application to nanogel systems for Wound Healing Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-06 Richa Jain, Ruchi Singh, Reena Badhwar, Tinku Gupta, Harvinder Popli
Objective The present research deals with sequential optimization strategy based on Central Composite Design to optimize the process variables for efficient production of Clitoria teratea (CLT) syn...
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Potential Anticancer Effect of Free and Nanoformulated Deferasirox for Breast Cancer Treatment: In-vitro and In-vivo Evaluation Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-02 Nadeen Diaa Abdel-Wahab, Mohamed Fawzi Kabil, Ibrahim M. El-Sherbiny, Mohamed F. Salama, Gehad El-Sayed, El-Said El-Sherbini
Background: Breast cancer (BC) stands as the second leading cause of mortality among women worldwide. Many chemotherapeutic treatments for BC come with significant adverse effects. Additionally, BC...
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Physicochemical interaction of rifampicin and ritonavir-lopinavir solid dispersion: an in-vitro and ex-vivo investigation Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-02 Athira R. Nair, Sai Krishna Anand Vullendula, Dani Lakshman Yarlagadda, Brahmam Bheemisetty, Swapnil J. Dengale, Krishnamurthy Bhat
To investigate the in-situ physicochemical interaction of Rifampicin and Ritonavir - Lopinavir Solid dispersion administered for the treatment of comorbid conditions i.e. Tuberculosis and HIV/AIDS....
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Comparative pharmacokinetic evaluation of glimepiride orodispersable and conventional tablets in rabbits Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-02-01 Altaf ur Rahman, Fazli Nasir, Muzna Ali Khattak, Talaya Hidayatullah, Sadia Pervez, Syeda Rabqa Zainab, Arbab Tahir Ali, Shazma Gohar, Gul e Maryam, Waleed H. Almalki
Glimepiride Orodispersable Tablets (ODT) were prepared with the goal to have rapid onset of action and higher bioavailability with ease administration to individuals with swallowing difficulty to a...
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Quantitative analysis of cephalexin in solid dosage form by Raman spectroscopy and chemometric tools Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Nida Ghafoor, Naeema Kanwal, Haq Nawaz, Muhammad Irfan Majeed, Nosheen Rashid, Shazra Ishtiaq, Rabiah Tariq, Kiran Kainat, Arslan Ali, Ayesha Anwar, Zainab Shoukat, Aiman Amir, Muhammad Imran
To use Raman Spectroscopy for qualitative and quantitative evaluation of pharmaceutical formulations of active pharmaceutical ingredient (API) of Cephalexin.Raman Spectroscopy is a noninvasive, non...
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Intranasal administration of innovative triamcinolone acetonide encapsulated cubosomal in situ gel: formulation and characterization Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Ruturaj Patil, Archana S. Patil, Krutuja Chougule, Yadishma Gaude, Rajashree S. Masareddy
The primary objective of the research was to develop a cubosomal in situ gel encapsulated with Triamcinolone acetonide (TCA) in order to enhance its penetration through the blood-brain barrier (BBB...
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Development of a novel direct compressible co-processed excipient and its application for formulation of Mirtazapine orally disintegrating tablets Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Ying Hui Loke, Yik-Ling Chew, Ashok Kumar Janakiraman, Siew-Keah Lee, A.B.M. Helal Uddin, Choon Fu Goh, Phei Er Kee, Hui Suan Ng, Long Chiau Ming, Kai Bin Liew
Orally disintegrating tablets (ODTs) are designed to dissolve in the oral cavity within 3 min, providing a convenient option for patients as they can be taken without water. Direct compression is t...
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Enhancing oral bioavailability of Ca-DTPA by self double emulsifying drug delivery system (SDEDDS) Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Vaishali Agrawal, Anjali Priyadarshani, Dharam Pal Pathak, Nidhi Sandal
BCS class III drug (highly soluble, poorly permeable) possesses low oral bioavailability. The research work highlights the utility of self-double emulsifying drug delivery system (SDEDDS) which are...
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In silico exploration of venlafaxine, a potential non-tricyclic antidepressant in a liposomal formulation for nose-to-brain drug delivery Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Sulekha Khute, Rajendra K. Jangde
Non-tricyclic antidepressants (non-TCAs) work by preventing the intake of norepinephrine and serotonin. Therefore, the aim of this study was to identify a potent non-TCAs and to develop liposomal f...
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Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using solid dispersion and effervescent disintegration technology Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Chao Li, Nanxin Li, Xingyu Chen, Xiaojuan Li, Chang Liu, Awn Abbas, Yueli Wang, Shuangcai Qi, Yifan Zhang, Dongbo Li, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li, Funeng Xu, Guangneng Peng, Hualin Fu
Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability.Here in, we aimed to explore the applicability of fast disintegrating tablets compressed f...
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Mixed Pluronic/lecithin micelles formulation for oral bioavailability of candesartan cilexetil drug: in vitro characterization and in vivo pharmacokinetic investigations Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Homraj Mahajan, Hemil S. Patel, Debes Ray, Vinod K. Aswal, Rakesh K. Sharma, Hemal Tandel
This study aimed to develop a mixed polymeric micelle formulation incorporating candesartan cilexetil (CAND) drug to enhance its oral bioavailability for the better treatment of hypertension.A Box–...
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Formulation development and evaluation of nasal in situ gel of promethazine hydrochloride Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-30 Surabhi V. Boraste, Sanjay B. Patil
The present work aims to develop mucoadhesive thermosensitive nasal in situ gel for Promethazine hydrochloride using quality by design (QbD) approach. It can reduce nasal mucociliary clearance (MCC...
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Revisiting the significance of nano-vitamin D for food fortification and therapeutic application Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-26 Gaurav K. Jain, Vidya Raina, Rakshita Grover, Jagriti Sharma, Musarrat Husain Warsi, Geeta Aggarwal, Prashant Kesharwani
Vitamin D (a prohormone) is an important micronutrient required by the body for skeletal homeostasis and a range of non-skeletal actions. Calcitriol, the active form of vitamin D, regulates a varie...
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Effect of stoichiometry upon the characteristics of quercetin-arginine cocrystals formulated through solution crystallization Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-24 Mahima Mishra, Shivanshu Agrawal, Pratap Bahadur, Sanjay Tiwari
The aim of this study is to demonstrate the effect of stoichiometry upon characteristics of quercetin-arginine (QCT-Arg) cocrystals.Quercetin (QCT) is a most abundant flavonoid in vegetables and fr...
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Development of oral formulation of Lepidium seeds significantly decreases the high blood glucose levels in diabetic rats: in vitro formulation and in vivo antidiabetic performance Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-24 Basmah N. Aldosari, Ahmed A. H. Abdellatif, Alanood Sunhat Almurshedi, Iman Mohammed Alfagih, Bushra Tawfeeq AlQuadeib, Asmaa Youssef A. Abbas, Yasser A. Hassan, Ahmed Abdelfattah, Hesham M. Tawfeek
Lepidium sativum, Garden Cress (GC), seeds have a lot of natural molecules with a pronounced activity against different disorders. It was reported that GC seeds have the ability to lower the blood ...
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Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-23 Yang Liu, Jia-yu Cai, Yang Liu, Lu Zhang, Rui-bo Guo, Xue-tao Li, Ling-yue Ma, Liang Kong
Glioma is the most common and deadly primary malignant tumor in adults. Treatment outcomes are ungratified due to the presence of blood–brain barrier (BBB), glioma stem cells (GSCs) and multidrug r...
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Integrating chemical similarity and bioequivalence: an overall evaluation of the quality consistency of traditional decoction and dispensing granule decoction of Amomum villosum Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-16 Yousong Yue, Haiyang Li, Manwen Xu, Lijie Ma, Xiaopeng Wang, Yan Miao, Lu Zhang, Xuelin Li, Ruixin Liu
This study aims to investigate the quality consistency between traditional decoction (TD) of Amomum villosum and its dispensing granule decoction (DGD). Fifteen batches of TD and nine batches of di...
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Solvent-free method for masking the bitter taste of azithromycin dihydrate using supercritical fluid technology Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-08 Hadeia Mashaqbeh, Rana M. Obaidat, Mo’tasem M. Alsmadi
The unpleasant extremely bitter taste of the orally administered broad-spectrum antibiotic azithromycin decreases patient compliance, especially in pediatrics. This issue can be overcome by decreas...
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Doxorubicin-sanguinarine nanoparticles: Formulation and evaluation of breast cancer cell apoptosis and cell cycle Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-05 Mahmoud Zaki El-Readi, Majed Abdurhman Abdulkarim, Ahmed A. H. Abdellatif, Mohamed E. Elzubeir, Bassem Refaat, Mohammad Althubiti, Riyad Adnan Almaimani, Mohammed Hasan Mukhtar, Issa Saad Al-Moraya, Safaa Yehia Eid
Background Therapeutic resistance fails cancer treatment. Drug-nanoparticle combinations overcome resistance. Sanguinarine-conjugated nanoparticles may boost sanguinarine's anticancer effects. Meth...
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Interdigitation of lipids for vesosomal formulation of ergotamine tartrate with caffeine: a futuristic trend of intranasal route Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2024-01-05 Preeti Dali, Pravin Shende
This research work aimed to form vesosomes using combination of two drugs ergotamine (ERG) and caffeine for synergistic activity when given intranasally resulting in faster absorption, steric stabi...
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Statement of Retraction: Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-12-20
Published in Drug Development and Industrial Pharmacy (Vol. 49, No. 12, 2023)
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Preparation of Piroxicam nanosuspensions by high pressure homogenization and evaluation of improved bioavailability Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-12-20 Okan Ali Aksoy, Merve Zanbak Çotaoğlu, Tugba Fatsa, Gizem Ruya Topal, Özgür Eşim, Berk Alp Göksel, Tuğrul Hoşbul, Cansel Köse Özkan, Ayhan Savaşer, Yalçın Özkan
Inflammation is a natural response of the organism, involving events responsible for releasing chemical mediators and requiring treatments of symptoms such as pain, redness, heat, swelling, and los...
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Characterization of withanolides and bacoside A-loaded proniosomes: effect on oxidative stress and survival under hypergravity in rodent model Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-12-20 Yallappa B. Saunshi, Corbon Godfrey David, Heartwin A. Pushpadass, Magdaline Eljeeva Emerald Franklin, Vaibhav Bhagwan Awachat, Veeranna R. Kadakol
This work provides characterization of withanolides and bacoside A proniosomes, and evaluating their potency in rat model for combating oxidative stress-induced blood–brain barrier (BBB) damage and...
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Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-12-20 Swapnali Vasant Birajdar, Farhan Mazahir, Awesh K. Yadav
We report the preparation, characterization, and in-vitro therapeutic evaluation of Metformin-Loaded, Transferrin-Poloxamer-Functionalized Chitosan Nanoparticles (TPMC-NPs) for their repurposing in...
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Synthesis and characterization of magnetic Ag–Fe3O4@polymer hybrid nanocomposite systems with promising antibacterial application Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-12-20 Basmah N. Aldosari, Mohamed Abd El-Aal, Essam F. Abo Zeid, Tarek M. Faris, Ashraf Aboelela, Ahmed A. H. Abdellatif, Hesham M. Tawfeek
Bacterial infections caused by different strains of bacteria still one of the most important disorders affecting humans worldwide. Polymers nanocomposite systems could be considered as an alternati...
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Evaluation of the effect of granule size of raw tableting materials on critical quality attributes of tablets during the continuous tablet manufacturing process using near-infrared spectroscopy Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-11-09 Makoto Otsuka, Tokiro Ogata, Yusuke Hattori, Tetsuo Sasaki
The effects of granule size of raw materials on tablet hardness (TH) and weight (TW) in the continuous tablet manufacturing process (CTMP) were investigated using near-infrared spectroscopy (NIRS)....
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Design of a pilot plant-type pharmaceutical reactor to address the problem of interchangeability of generic semisolid formulations Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-11-09 Emiliano Frenquelli, Daniel A. Real, Juan M. Llabot, Liliana Pierella, María L. Formica, Juan P. Real, Santiago D. Palma
This research aims to design and develop a pilot plant-type pharmaceutical reactor with a strong focus on its volumetric capacity and heat transfer capabilities. The primary goal is to replicate de...
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Evaluation of the in vitro performance of generic and original adapalene gel Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-11-09 Changying Xin, Kai Duo, Xinying Yu, Liqun Liu
The aim was to evaluate the difference of the in vitro behavior between the commercially available generic adapalene gel and original product with Topical Classification System (TCS), and to analyz...
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Effective seed cake extract of O. sanctum inducing the p53 dependent apoptotic pathway in oral cancer cells Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-11-09 Yash Sharma, Rupa Mishra, Amritpal Kaur, Mausumi Bharadwaj, Kumud Bala
Present study was to observe the therapeutic aspects of seed cake extracts of Ocimum sanctum against the oral cancer cell line with the activation of p53 apoptotic pathway.Seed cake extracts were c...
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Formulation development of Lornoxicam loaded heat triggered ocular in-situ gel using factorial design Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-10-14 Heybet Kerem Polat, Sedat Ünal, Eren Aytekin, Nasıf Fatih Karakuyu, Esra Pezik, Muhammet Kerim Haydar, Nihat Kurt, Osman Doğan, Behzad Mokhtare
In the current research, lornoxicam-loaded in situ gels were developed, and their potential usage in ocular inflammation was evaluated.Lornoxicam cyclodextrin complex prepared with hydroxypropyl me...
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Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer’s disease Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-10-14 Avinash R. Tekade, Mayuri R. Suryavanshi, Ashutosh B. Shewale, Vilas S. Patil
The primary objective of this study was to develop nanostructured lipid carriers of donepezil hydrochloride (DNZ HCl) for effective management of Alzheimer’s disease (AD).Intranasal administration ...
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Utilization of response surface design for development and optimization of rosuvastatin calcium-loaded nano-squarticles for hair growth stimulating VEGF and IGF production: in-vitro and in-vivo evaluation Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-10-14 Mervat Shafik Ibrahim, Nihal Mohamed Elmahdy Elsayyad, Abeer Salama, Shereen H. Noshi
Countless individuals experience negative emotions as hair loss pattern affects their self-esteem and well-being. Rosuvastatin calcium (Ca-RUV) was reported to stimulate the growth of the hair in t...
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The folate-linked chitosan-coated Kaempferol/HSA nano-transporters (FCKH-NTs) as the selective apoptotic inducer in human MCF-7 breast cancer cell line Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-10-10 Mahshad Mollaei, Masoud Homayouni Tabrizi, Ali Es-haghi
Kaempferol, the natural bioactive flavonoid, has been utilized as an efficient anti-breast cancer compound. In the current study, the Kaempferol’s cellular uptake and its aqueous solubility were im...
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Preparation and In Vitro Characterization of Curcumin Loaded Chitosan-Hyaluronic Acid Polyelectrolyte Complex Based Hydrogels Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-10-02 Sema Arısoy, Emine Şalva
The manuscript aims to prepare and comprehensively characterize curcumin-loaded chitosan-hyaluronic acid polyelectrolyte complex (PEC) hydrogels through in vitro assessments. By elucidating the for...
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Nicotine Transport across Calu-3 Cell Monolayer: Effect of Nicotine Salts and Flavored E-liquids Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-09-26 Ming Chu, Jingjing Deng, Hao Hu, Ruoxi Wang, Ding Li, Zuxin Chen, Xin-an Liu, Jin Lu
This study aimed to investigate the transport capability of nicotine across Calu-3 cell monolayer in various nicotine forms, including nicotine freebase, nicotine salts, and flavored e-liquids with...
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Dual-targeted delivery system using hollow silica nanoparticles with H+-triggered bubble generating characteristic coated with hyaluronic acid and AS1411 for cancer therapy Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-09-29 Salimeh Mirzaei, Zahra Khademi, Reza Zolfaghari, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Herein, a dual-targeting delivery system using mesoporous silica nanoparticles with hollow structures (HMSNs) was developed for the specific delivery of epirubicin (EPI) to cancer cells and introdu...
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Novel Co-Crystal of 3-Methylcinnamic Acid with Berberine(1:1): Synthesis, Characterization, and Intestinal Absorption Property Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-09-19 Yong He, Shiyun Chen, Mengmeng Li, Yonghao Gao, Huiyi Feng, Qasim Umar, Dengke Yin, Yisi Feng
To synthesis a novel “Pharmaceutical Cocrystal” of berberine (BBR) with coformer 3-methylcinnamic acid (3MCA) for increasing its solubility and intestinal absorption property.BBR-HCl has poor lipos...
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Breaking Barriers: Bilosomes Gel Potentials to Pave the Way for Transdermal Breast Cancer Treatment with Tamoxifen Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-09-18 Reem Abou Assi, Ibrahim M Abdulbaqi, Siew Mei Tan, Habibah A. Wahab, Yusrida Darwis, Siok-Yee Chan
Breast cancer affects women globally, regardless of age or location. On the other hand, Tamoxifen (TXN), a class II biopharmaceutical drug is acting as a prophylactic/treating agent for women at ri...
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Evaluation of the anticancer activity of Origanum Marjoram as a safe natural drink for daily use Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-09-13 Ahmed A. H. Abdellatif, Mansour Alsharidah
Chemotherapeutic agents have numerous side effects. There is a major interest in using natural and safe plants as food or drink to prevent from cancer. Origanum marjoram (OMAE) is a medicinal plant...
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ApoE-modified liposomes encapsulating resveratrol and salidroside alleviate manifestations of Alzheimer’s disease in APP/PS-1 mice Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-09-04 Mu-Han Chen, Xin-Ze Liu, Xiu-Wu Qu, Rui-Bo Guo, Lu Zhang, Liang Kong, Yang Yu, Yang Liu, Juan Zang, Xiu-Ying Li, Xue-Tao Li
Alzheimer’s disease (AD) is a neurodegenerative disease that is associated with aging and is influenced by both genetic and environmental factors. Several studies and clinical trials have demonstra...
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Evaluation of particle size distribution of sub-visible particles in powder injections with different packaging forms – small-sized sub-visible particles should not be ignored Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-08-30 Tao Wang, Enhao Lu, Qiwen Dai, Xueli Huang, Qiquan Yao, Xianyi Sha
Sub-visible particle, or particulate matter, is an important indicator in the safety assessment of clinical infusions. The present study aims to evaluate the effect of the packaging formats of anti...
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Multifunctional nanoparticles encapsulating methotrexate and curcumin for holistic management of rheumatoid arthritis: in-vitro and pre-clinical assessment Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-08-14 Ayesha Syed, Preeti Karwa, Kusum Devi Vemula, Salwa
Abstract Purpose Bovine serum albumin (BSA) nanoparticles (BSA-MTX-CUR-NPs) encapsulating methotrexate (MTX) and curcumin (CUR) was developed with an aim to co-deliver the drugs at the inflamed joint so as to maximize the therapeutic efficacy and alleviate toxic side effects associated with MTX. Methods Nanoparticle albumin-bound technology was used to formulate nanoparticles, followed by characterization
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Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model Drug Dev. Ind. Pharm. (IF 3.4) Pub Date : 2023-08-11 Shubham Kataria, Supriya Roy, Mohini Chaurasia, Himani Awasthi, Zeeshan Fatima, Rammani Prasad, Dipti Srivastava
Abstract Objective The present work aims to formulate nanoemulgel of crisaborole (CB) and evaluate its effectiveness against 2,4-Di-nitrochlorobenzene induced (DNCB) atopic dermatitis (AD) in mice. Significance AD is a chronic inflammation of the skin affecting the quality of life. CB is a topical PDE4 inhibitor marketed as a 2% ointment. It, however, possesses poor aqueous solubility. An o/w nanoemulsion