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Safety Assessment of Basic Red 76 as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-03-13 Priya Cherian, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Basic Red 76, which is reported to function in cosmetics as a hair colorant and hair-conditioning agent. The Panel reviewed the available data to determine the safety of this ingredient. The Panel concluded that Basic Red 76 is safe for use as a hair dye ingredient in the present practices of use and concentration described
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In Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input Combinations Int. J. Toxicol. (IF 2.2) Pub Date : 2024-03-13 Emmanuel Boulay, Eric Troncy, Vincent Jacquemet, Hai Huang, Michael K Pugsley, Anne-Marie Downey, Rafael Venegas Baca, Simon Authier
In silico modeling offers an opportunity to supplement and accelerate cardiac safety testing. With in silico modeling, computational simulation methods are used to predict electrophysiological interactions and pharmacological effects of novel drugs on critical physiological processes. The O’Hara-Rudy’s model was developed to predict the response to different ion channel inhibition levels on cardiac
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Safety Assessment of Polysilicone-11 as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-03-12 Priya Cherian, Wilma F. Bergfeld, Donald V. Belsito, David E. Cohen, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Lisa A. Peterson, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Polysilicone-11 as used in cosmetic formulations. This ingredient is reported to function as a film former. The Panel considered the available data and concluded that Polysilicone-11 is safe in cosmetics in the present practices of use and concentration described in this safety assessment.
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Safety Assessment of Hydrogen Peroxide as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-03-12 Lillian C. Becker, Priya A. Cherian, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Hydrogen Peroxide for use in cosmetics. This ingredient is reported to function in cosmetics as an antimicrobial agent, cosmetic biocide, oral health care agent, and oxidizing agent. The Panel reviewed the data relevant to the safety of this ingredient and concluded that Hydrogen Peroxide is safe in cosmetics in the present
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Safety Assessment of Capryloyl Salicylic Acid as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-03-11 Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Lisa A. Peterson, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Capryloyl Salicylic Acid in cosmetic products; this ingredient is reported to function as a skin conditioning agent. The Panel reviewed relevant data relating to the safety of this ingredient in cosmetic formulations, and concluded that the available data are insufficient to make a determination that Capryloyl Salicylic
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Safety Assessment of Hydroxyethyl Urea as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-03-11 Alice Akinsulie, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Hydroxyethyl Urea, which is reported to function as a humectant and a hair and skin conditioning agent. The Panel reviewed the available data to determine the safety of this ingredient. The Panel concluded that Hydroxyethyl Urea is safe in cosmetics in the present practices of use and concentration described in the safety
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Ayahuasca and Dimethyltryptamine Adverse Events and Toxicity Analysis: A Systematic Thematic Review Int. J. Toxicol. (IF 2.2) Pub Date : 2024-02-16 Eleanor White, Tom Kennedy, Simon Ruffell, Daniel Perkins, Jerome Sarris
The objective of this paper is to conduct a systematic thematic review of adverse events, safety, and toxicity of traditional ayahuasca plant preparations and its main psychoactive alkaloids (dimethyltryptamine [DMT], harmine, harmaline, and tetrahydroharmine), including discussing clinical considerations (within clinical trials or approved settings). A systematic literature search of preclinical,
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Safety Assessment of Soy-Derived Ingredients as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-02-12 Priya Cherian, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Lisa A. Peterson, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 28 soy-derived ingredients as used in cosmetic products. These ingredients are reported to primarily function as antioxidants, skin protectants, skin-conditioning agents, and hair-conditioning agents. The Panel considered the available data relating to the safety of these ingredients in cosmetic formulations, and concluded
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Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays Int. J. Toxicol. (IF 2.2) Pub Date : 2024-02-08 Alan P. Brown, Gregory S. Friedrichs, Hai-Ming Tang, Martin Traebert, Valerie Weber, Nancy Yao, Gan-Xin Yan
During drug discovery, small molecules are typically assayed in vitro for secondary pharmacology effects, which include ion channels relevant to cardiac electrophysiology. Compound A was an irreversible inhibitor of myeloperoxidase investigated for the treatment of peripheral artery disease. Oral doses in dogs at ≥5 mg/kg resulted in cardiac arrhythmias in a dose-dependent manner (at Cmax, free ≥1
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Safety Assessment of Zinc Salts as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-01-27 Laura N. Scott, Monice Fiume, Jinqiu Zhu, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 27 inorganic and organometallic zinc salts as used in cosmetic formulations; these salts are specifically of the 2+ (II) oxidation state cation of zinc. These ingredients included in this report have various reported functions in cosmetics, including hair conditioning agents, skin conditioning agents, cosmetic astringents
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Application of the Key Characteristics of Carcinogens to Bisphenol A Int. J. Toxicol. (IF 2.2) Pub Date : 2024-01-11 Karin Ricker, Vanessa Cheng, Chingyi Jennifer Hsieh, Feng C. Tsai, Gwendolyn Osborne, Kate Li, Meltem Yilmazer-Musa, Martha S. Sandy, Vincent J. Cogliano, Rose Schmitz, Meng Sun
The ten key characteristics (KCs) of carcinogens are based on characteristics of known human carcinogens and encompass many types of endpoints. We propose that an objective review of the large amount of cancer mechanistic evidence for the chemical bisphenol A (BPA) can be achieved through use of these KCs. A search on metabolic and mechanistic data relevant to the carcinogenicity of BPA was conducted
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In vitro Safety Assessment of Extracts and Compounds From Plants as Sunscreen Ingredients Int. J. Toxicol. (IF 2.2) Pub Date : 2024-01-06 Silvia Juliana Flórez González, Elena E. Stashenko, Raquel Elvira Ocazionez, María Pilar Vinardell, Jorge Luis Fuentes
This work investigated the safety of extracts obtained from plants growing in Colombia, which have previously shown UV-filter/antigenotoxic properties. The compounds in plant extracts obtained by the supercritical fluid (CO2) extraction method were identified using gas chromatography coupled to mass spectrometry (GC/MS) analysis. Cytotoxicity measured as cytotoxic concentration 50% (CC50) and genotoxicity
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Safety Assessment of Alkane Diols as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-01-04 Laura N. Scott, Monice Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 10 alkane diol ingredients as used in cosmetics. The alkane diols are structurally related to each other as small diols, and most are reported to function in cosmetics as solvents. The Panel reviewed the relevant data for these ingredients, and concluded that seven alkane diols are safe in cosmetics in the present practices
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Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2024-01-03 Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 13 Butyrospermum parkii (shea)-derived ingredients, which are most frequently reported to function in cosmetics as skin and hair conditioning agents. The Panel reviewed the available data to determine the safety of these ingredients. Because final product formulations may contain multiple botanicals, each containing similar
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Safety Assessment of Polyfluorinated Polymers as Used in Cosmetics. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-12-01 Wilbur Johnson,Wilma F Bergfeld,Donald V Belsito,Ronald A Hill,Curtis D Klaassen,Daniel C Liebler,James G Marks,Ronald C Shank,Thomas J Slaga,Paul W Snyder,Monice Fiume,Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 12 polyfluorinated polymers in cosmetic products; most of these ingredients have the reported function of film former in common. However, PTFE, the only ingredient that is reported as currently used in cosmetics, functions as a bulking agent and slip modifier, but not as a film former. The Panel reviewed data relevant to
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Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Exacerbates Methamphetamine-Induced Activation of Microglia and Neuroinflammation. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-11-25 Yanxia Peng,Genmeng Yang,Shangwen Wang,Wanrong Lin,Lihua Zhu,Wenjuan Dong,Baoyu Shen,Qianyun Nie,Shijun Hong,Lihua Li
Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to neurotoxicity and drug addiction. Studies have shown that neurotoxicity is strongly associated with METH-induced neuroinflammation, and microglia are the key drivers of neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2)
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A Review of Hydrotropic Solubilization Techniques for Enhancing the Bioavailability of Poorly Soluble Drugs. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-11-24 Uddeshya Sharma,Kamal Saroha
Hydrotropic solubilization is a technique that can be used to improve the solubility of drugs that are poorly soluble. This technique involves adding a large amount of a second solute, known as a hydrotrope, which increases the aqueous solubility of the poorly soluble drug. Hydrotropes such as sodium citrate, sodium benzoate, and urea have been shown to be effective in enhancing the solubility of poorly
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In Vitro Evaluation of Vancomycin-Induced Toxicity in Human Primary Knee Chondrocytes. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-11-21 Susan Hall,Jane Grayson,Gary Grant,Christopher Vertullo,Shailendra Anoopkumar-Dukie
Septic arthritis as a complication of orthopaedic joint surgery can have catastrophic outcomes for patients. To minimise infection risk associated with elective orthopaedics, topical vancomycin during surgery has become increasingly common. Evidence suggests that high concentrations of vancomycin, following direct application of the drug to the joint, are toxic towards various local cell types in the
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Toxicological Assessment of Higher Olefins in OECD TG 422 Repeated Dose and Reproductive /Developmental Toxicity Screening Tests in Han Wistar Rats. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-11-07 Quan Shi,Juan-Carlos Carrillo,Michael G Penman,Hua Shen,Colin M North,Sophie Jia,Tilly Borsboom-Patel,Yuan Tian,Fabienne Hubert,Jason C Manton,Peter J Boogaard
Higher olefins (HO) are used primarily as intermediates in the production of other chemicals, such as polymers, fatty acids, plasticizer alcohols, surfactants, lubricants, amine oxides, and detergent alcohols. The potential toxicity of five HO (i.e., 1-Octene, Nonene, Decene, Hexadecene, and 1-Octadecene) with carbon ranging from C8 to C18 was examined in a combined repeated dose and reproduction/developmental
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An Evaluation of Zebrafish, an Emerging Model Analyzing the Effects of Toxicants on Cognitive and Neuromuscular Function. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-10-30 Truth Clevenger,Jakob Paz,Andrew Stafford,Deborah Amos,A Wallace Hayes
An emerging alternative to conventional animal models in toxicology research is the zebrafish. Their accelerated development, regenerative capacity, transparent physical appearance, ability to be genetically manipulated, and ease of housing and care make them feasible and efficient experimental models. Nonetheless, their most esteemed asset is their 70% (+) genetic similarity with the human genome
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Amended Safety Assessment of Mentha piperita (Peppermint)-Derived Ingredients as Used in Cosmetics. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-10-06 Wilbur Johnson,Wilma F Bergfeld,Donald V Belsito,Ronald A Hill,Curtis D Klaassen,Daniel C Liebler,James G Marks,Ronald C Shank,Thomas J Slaga,Paul W Snyder,Monice Fiume,Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of M piperita (peppermint)-derived ingredients. The Panel reviewed data relevant to the safety of these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituent(s) of concern, formulators are advised to be aware of these constituents and avoid reaching levels that
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Preclinical In-Vivo Safety and Toxicokinetics of D-PLEX100 in an Abdominal Surgery Incision Model in Juvenile Miniature Swine. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-10-03 Yuval Ramot,Abraham Nyska,Meidan Dvir,Shlomo Nedvetzki,Sefi Rosenfeld,Noam Emanuel
D-PLEX100 (D-PLEX) is a novel product candidate made of a polymer-lipid-based matrix (PLEX platform) which contains doxycycline that is being released at a constant rate for 30 days. D-PLEX was developed to prevent surgical site infections, which are a major global health challenge. Previous studies have shown its safety in adult humans, adult swine, and adult rabbits. The aim of this study was to
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Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-09-29 Christina L Burnett,Wilma F Bergfeld,Donald V Belsito,David E Cohen,Curtis D Klaassen,Allan E Rettie,David Ross,Thomas J Slaga,Paul W Snyder,Susan Tilton,Monice Fiume,Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 1983, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal is safe for topical application to humans in the practices of use
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Glycol Stearate and Glycol Stearate SE. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-09-28 Regina Tucker,Wilma F Bergfeld,Donald V Belsito,David E Cohen,Curtis D Klaassen,Daniel C Liebler,Allan E Rettie,David Ross,Thomas J Slaga,Paul W Snyder,Susan Tilton,Monice Fiume,Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1982, along with updated information regarding product types and concentrations of use, and confirmed that Glycol Stearate and Glycol Stearate SE are safe as cosmetic ingredients in the practices of use and concentration as described in this report.
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Cottonseed Glyceride and Hydrogenated Cottonseed Glyceride. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-09-28 Preethi S Raj,Wilma F Bergfeld,Donald V Belsito,David E Cohen,Curtis D Klaassen,Daniel C Liebler,Allan E Rettie,David Ross,Thomas J Slaga,Paul W Snyder,Susan Tilton,Monice Fiume,Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 2001, along with updated information regarding product types and concentrations of use, and confirmed that Cottonseed Glyceride and Hydrogenated Cottonseed Glyceride are safe as cosmetic ingredients in the practices of use and concentration as described in this report, provided that established
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Dioscorea Villosa (Wild Yam) Root Extract. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-09-26 Preethi S Raj,Wilma F Bergfeld,Donald V Belsito,David E Cohen,Curtis D Klaassen,Allan E Rettie,David Ross,Thomas J Slaga,Paul W Snyder,Susan Tilton,Monice Fiume,Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 2004, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that Dioscorea Villosa (Wild Yam) Root Extract is safe as a cosmetic ingredient in the practices of use and concentration
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Alternatives to Monkey Reproductive Toxicology Testing for Biotherapeutics. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-09-15 Alan M Hoberman,Kazushige Maki,Fumito Mikashima,Misaki Naota,Ronald L Wange,Janice A Lansita,Shawna L Weis
Embryofetal toxicity studies are conducted to support inclusion of women of childbearing potential in clinical trials and to support labeling for the marketed pharmaceutical product. For biopharmaceuticals, which frequently lack activity in the rodent or rabbit, the nonhuman primate is the standard model to evaluate embryofetal toxicity. These studies have become increasingly challenging to conduct
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Non-Clinical Toxicology Evaluation of the Novel Non-ATP Competitive Oral PI3 Kinase Delta Inhibitor Roginolisib. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-09-04 Lars van der Veen,Michael Schmitt,Marcel A Deken,Michael Lahn
Roginolisib (IOA-244) is a novel, non-ATP competitive phosphoinositide-3-kinase (PI3K) delta inhibitor that regulates Akt/mTOR signaling. Roginolisib was administered once daily to rats and dogs in dose-range finding (DRF) and 4-week GLP toxicology studies. Free plasma levels of roginolisib exceeded the cellular target engagement IC90 for PI3Kδ for ≥12 hours at doses of 5 mg/kg, the IC90 for PI3Kβ
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Assessing the Safety of MA-[D-Leu-4]-OB3, a Synthetic Peptide Leptin Mimetic: Two Pre-Clinical Toxicity Studies in Male and Female C57BL/6 Mice. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-08-09 Forrest Enemark,Zachary M Novakovic,Patricia Grasso
Although the regulatory influence of leptin on energy balance, glycemic control, immunity, reproduction, and cognition is well established, its clinical application to common obesity and its co-morbidities has been limited by impaired transport across the blood-brain barrier, and tendencies to induce adverse side effects. To circumvent these drawbacks, MA-[D-Leu-4]-OB3, a leptin-related synthetic peptide
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Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951), a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor, in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-07-22 Yusuke Kemmochi,Kaoru Toyoda,Tomio Ishida,Yuzo Yasui,Toshiyuki Shoda
Enarodustat (JTZ-951) is an oral hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor for the treatment of anemia with chronic kidney disease. Carcinogenicity of enarodustat was evaluated in a 26-week repeated oral dose study in Transgenic rasH2 (Tg.rasH2) mice and a 2-year repeated oral dose study in Sprague-Dawley (SD) rats. The highest dose levels were set at 6 mg/kg in the Tg.rasH2 mouse
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Recent Advances in Drug Discovery Toxicology. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-07-15 Bowen Tang,Vijay More
Major advances in scientific discovery and insights that stem from the development and use of new techniques and models can bring remarkable progress to conventional toxicology. Although animal testing is still considered as the "gold standard" in traditional toxicity testing, there is a necessity for shift from animal testing to alternative methods regarding the drug safety testing owing to the emerging
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Pharmaceutical Industry Perspective on the Non-Clinical Evaluation of Novel Excipients: Results From an Industry Survey Conducted by the IQ Novel Excipient Working Group. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-07-14 Paul S Giffen,Lorrene A Buckley,Jason Pinkstaff
Excipients are essential components within drug products that contribute significantly to their overall quality, effectiveness, and safety. There is a lack of global, harmonized guidance relating to the non-clinical testing of novel excipients which is perceived to create uncertainty and strategic risk, potentially hindering innovation and disincentivizing their use. To test these perceptions, the
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Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-06-23 Nicole V Soucy,Susie Masten,Carla Caro,Ann M Arthur,Nadia H Moore,Michelle J Hooth,Robert Mitkus
The American Board of Toxicology (ABT), in consultation with ACT Credentialing & Career Services (ACT), performed a practice analysis study of general toxicology in 2020-21. This work follows up on an initial practice analysis commissioned by the ABT and conducted in 2014-2015, results of which were published in 2016. The purpose of the current, second-generation study was to update and validate the
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Corrigendum to: "Toxicology Certification: The Need, the Value, and an Evolving Landscape". Int. J. Toxicol. (IF 2.2) Pub Date : 2023-06-19
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Transcription Factor E2F8 Promotes Cisplatin Resistance in Hepatocellular Carcinoma by Regulating DNA Damage via NUSAP1. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-06-18 Jianqiao Kong,Song Xu,Peng Zhang,Yi Wang
DNA damage repair has been the key mechanism of cisplatin resistance in hepatocellular carcinoma (HCC). The present study elucidated the molecular mechanism by which nucleolar and spindle-associated protein 1 (NUSAP1) influenced cisplatin tolerance in HCC by regulating DNA damage. First, high mRNA expression of E2F8 and NUSAP1 in HCC was detected by real-time quantitative PCR in cells and tumor tissue
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High-Throughput Drug Screen for Potential Combinations With Venetoclax Guides the Treatment of Transformed Follicular Lymphoma. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-06-04 Zhifeng Li,Guangchao Pan,Mengya Zhong,Li Zhang,Xingxing Yu,Jie Zha,Bing Xu
Transformed follicular lymphoma (t-FL) is an aggressive malignancy that is refractory and rapidly progressing with poor prognosis. There is currently no effective treatment. High-throughput screening (HTS) platforms are used to profile the sensitivity or toxicity of hundreds of drug molecules, and this approach is applied to identify potential effective treatments for t-FL. We randomly selected a compound
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Safety Assessment of Soy Proteins and Peptides as Used in Cosmetics. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-06-02 Christina L Burnett,Wilma F Bergfeld,Donald V Belsito,Ronald A Hill,Curtis D Klaassen,Daniel C Liebler,James G Marks,Ronald C Shank,Thomas J Slaga,Paul W Snyder,Monice Fiume,Bart Heldreth
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of soy proteins and peptides, which function in cosmetics primarily as hair conditioning agents and skin-conditioning agents-miscellaneous. The Panel considered relevant data related to these ingredients. The Panel concluded that soy proteins and peptides are safe in cosmetics in the present practices of use and concentration
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Quantitative Risk Assessment of Dermal Sensitization Potential Following Use of Shampoo Products Containing the Formaldehyde Releasing Preservative DMDM Hydantoin Int. J. Toxicol. (IF 2.2) Pub Date : 2023-05-13 Chloe K. Stewart, Jillian Parker, Ruth Hwang, Melissa Vincent, Ernest Fung
Historically, formaldehyde was used as a preservative in personal care products to extend product shelf-life; however, given its skin sensitization potential it has been phased out of use and repla...
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Harihara M. Mehendale: A Life Dedicated to Mentoring and Research. Int. J. Toxicol. (IF 2.2) Pub Date : 2023-05-13 Udayan Apte,S Satheesh Anand,Murali Badanthadka,Jaya Chilakapati,Lawrence R Curtis,Vivek Dadhania,Sivarao V Digavalli,Urmila Kodavanti,Prasada Rao Kodavanti,Pallavi Limaye,Raja Mangipudy,Subramanya N Murthy,Binu Philip,Pratibha Rao,Sharmilee Sawant,Kartik Shankar,Vishal Vaidya,Tao Wang
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Toxicology Certification: The Need, the Value, and an Evolving Landscape Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-28 Douglas A. Donahue, Leigh Ann Burns-Naas
Certification in toxicology remains a subject of interest to those in the field, as evidenced by the number of presentations at major meetings and publications in the past decade. In 2009, Brock an...
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Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-26 Erin McDevitt, Lucie Henein, Anna Crawford, Sandeep Kondakala, Darian Young, Edward Meek, George E. Howell, III
The overall prevalence of metabolic diseases such as type 2 diabetes (T2D) and associated co-morbidities have increased at an alarming rate in the United States and worldwide. There is a growing bo...
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Localization of the Adductor Tubercle in the Skeletally Immature: A Computed Tomography Study With Patellofemoral Surgical Implications Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Sahir S. Jabbouri, William McLaughlin, Peter Joo, Daniel Cooperman, John P. Fulkerson, David B. Frumberg
Background:The adductor tubercle of the distal femur is utilized by surgeons as an anatomic landmark to identify graft anchor placement during medial patellofemoral ligament (MPFL) and medial quadr...
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Linkage Between Fields of Focus in High School Career Technical Education and College Majors Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Zeyu Xu, Ben Backes
This study examines the extent to which students obtain postsecondary credentials in the career technical education (CTE) fields of focus they choose in high school. Using school fixed-effects mode...
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Ties That Bind? The Teaching and Post-Teaching Trajectories of Black and Latino/a Community Insiders and Elite College Graduates Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Andrew Brantlinger, Blake O’Neal Turner, Angela Valenzuela
Community teachers, particularly those who are Black and Latinx, are assumed to improve retention and outcomes depending on retention in schools that serve low-income Black and Latinx students. Bas...
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Testing an Explanation for Summer Learning Loss: Differential Examinee Effort Between Spring and Fall Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Megan Kuhfeld, James Soland, Brennan Register, Andrew McEachin
Summer learning loss is a perennial concern for educators and parents alike. However, researchers have recently questioned whether summer learning loss is just a statistical artifact driven by how ...
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The Relationship Between Cumulative Ecological Risk and Problematic Smartphone Use Among Chinese College Students: Based on Latent Profile Analysis Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Jinliang Guan, Jinliang Guan, Wangyan Ma, Chengzhen Liu
The aim of the current study is to explore the number of classes of cumulative ecological risk with latent profile analysis. Furthermore, the relationships between the classes of cumulative ecologi...
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Ken Plummer, editor Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Feona Attwood
Many of the relationships described in this special issue, put together to honour the work of Ken Plummer, focus on Essex connections, intergenerational friendships, or particular intellectual conc...
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An Ode to Humans From The Mouth of Coal Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 John Christopher Haddox
Appalachia and coal have a historically challenging relationship with each other. Coal has been the backbone of many Appalachian economies. Along with the economic benefits of coal have come many n...
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Autoclave process parameters affecting mechanical and thermomechanical properties of CFRP laminates using response surface methodology Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Abd Baghad, Khalil El Mabrouk
Autoclave curing is a manufacturing process for high-performance parts based on carbon fiber–reinforced polymers (CFRPs) used for large aircraft parts. Today, this manufacturing process is the refe...
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The Risk, Need, and Responsivity Relevance of Working Alliance in a Sexual Offense Treatment Program: Its Intersection With Psychopathy, Diversity, and Treatment Change Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-24 Mark E. Olver, Keira C. Stockdale, Emily K. Riemer
The current study examined the self-reported working alliance of men attending a high intensity sexual offense treatment program and its associations with psychopathy, sexual violence risk, treatme...
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Clinicopathologic features in childhood-onset lupus nephritis with antineutrophil cytoplasmic antibody positivity——a multi-center retrospective study Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-13 Bei Jin, Cheng Cheng, Meizhen Tan, Jun Huang, Lizhi Chen, Zhilang Lin, Shuhan Zeng, Zihua Yu, Yingjie Li, Xiaoyun Jiang
BackgroundPositive antineutrophil cytoplasmic antibody (ANCA) serology in adult-onset lupus nephritis (LN) is associated with more active disease and distinct renal pathology, but data with respect...
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Social Ontology and Evaluation—A Comment on “Framing Evaluation in Reality: An Introduction to Ontologically Integrative Evaluation” Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-13 Robert Picciotto
According to Jennifer Billman, western evaluation bias against indigenous thinking is due to ontological incompetence. If so, the solution she offers (a highly abstract list of criteria) is inadequ...
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Appropriateness of Recommendations Provided by ChatGPT to Interventional Radiologists Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-13 Maxime Barat, Philippe Soyer, Anthony Dohan
Purpose: The purpose of this study was to analyze the answers provided by ChatGPT to various questions in the field of interventional radiology (IR) and compare their correctness to a consensus of ...
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Posterior Cranial Distraction in Craniosynostosis: A Systematic Review of the Literature Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-13 Ibrahim Khansa, Annie I. Drapeau, Gregory D. Pearson
ObjectivePosterior cranial distraction (PCD) is a surgical technique to address craniosynostosis, especially in syndromic patients. The technique has the ability to significantly expand the cranium...
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Gender(ed) violence in neo-authoritarian times Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-13 Leticia Sabsay
As conservative and neo-authoritarian tendencies in Europe move across political and geo-cultural borders, we bear witness to a renewed attack on gender and sexual rights. This is a challenge to de...
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Visual negotiation of identity and settlement of Poles in the so-called Recovered Territories: East Side Story by Anne Peschken and Marek Pisarsky Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-13 Marta Smolińska
This text is an analysis of a series of pinhole photographs, by Anne Peschken and Marek Pisarsky (Urban Art), entitled East Side Story I (Myślibórz). Photo research on migration and arrival stories...
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Walking hand in hand: The role of affection-sharing in understanding the social network effect in same-sex, mixed-sex, and gender-diverse relationships Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-13 Karen L Blair, Chelsea Hudson, Diane Holmberg
Individuals who perceive greater support or approval for their relationships from friends and family also report greater relationship stability and commitment and better mental and physical health ...
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Safety Assessment of Eucalyptus globulus (Eucalyptus)-Derived Ingredients as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2023-04-03 Lillian C. Becker, Alice Akinsulie, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
This is a safety assessment of 6 Eucalyptus globulus (eucalyptus)-derived ingredients as used in cosmetics. The reported functions of the Eucalyptus globulus (eucalyptus)-derived ingredients includ...
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Safety Assessment of Helianthus annuus (Sunflower)-Derived Ingredients as Used in Cosmetics Int. J. Toxicol. (IF 2.2) Pub Date : 2023-03-30 Lillian C. Becker, Ivan J. Boyer, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Jr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth
This is a review of the scientific literature and unpublished data that are relevant for assessing the safety of 12 Helianthus annuus (sunflower)-derived ingredients as used in cosmetics. Because f...