样式: 排序: IF: - GO 导出 标记为已读
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TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-03-18 Sven Jacob, Ilja Balonov, Vindi Jurinovic, Christian Heiliger, Tengis Tschaidse, Jörg Kumbrink, Thomas Kirchner, Jens Werner, Martin K. Angele, Marlies Michl, Jens Neumann
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The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-03-15 Sarah Libring, Emily D. Berestesky, Cynthia A. Reinhart-King
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Current pharmacologic treatment of brain metastasis in non-small cell lung cancer Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-03-11 Takae Okuno, Takeshi Isobe, Yukari Tsubata
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From pre-clinical to translational brain metastasis research: current challenges and emerging opportunities Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-03-02 Emilija Aleksandrovic, Siyuan Zhang, Dihua Yu
Brain metastasis, characterized by poor clinical outcomes, is a devastating disease. Despite significant mechanistic and therapeutic advances in recent years, pivotal improvements in clinical interventions have remained elusive. The heterogeneous nature of the primary tumor of origin, complications in drug delivery across the blood–brain barrier, and the distinct microenvironment collectively pose
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Differentiation of benign and metastatic lymph nodes in soft tissue sarcoma Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-29 Anton Burkhard-Meier, Vindi Jurinovic, Luc M. Berclaz, Markus Albertsmeier, Hans Roland Dürr, Alexander Klein, Thomas Knösel, Dorit Di Gioia, Lena M. Unterrainer, Nina-Sophie Schmidt-Hegemann, Jens Ricke, Michael von Bergwelt-Baildon, Wolfgang G. Kunz, Lars H. Lindner
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Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-28
Abstract High rates of mortality in non-small cell lung cancer lung cancer is due to inherent and acquired resistance to systemic therapies and subsequent metastatic burden. Metastasis is supported by suppression of the immune system at secondary organs and within the circulation. Modulation of the immune system is now being exploited as a therapeutic target with immune checkpoint inhibitors. The tracking
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Prediction of transformation in the histopathological growth pattern of colorectal liver metastases after chemotherapy using CT-based radiomics Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-28 Shengcai Wei, Xinyi Gou, Yinli Zhang, Jingjing Cui, Xiaoming Liu, Nan Hong, Weiqi Sheng, Jin Cheng, Yi Wang
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CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-β/SMAD signaling Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-24
Abstract Objective Aberrant expression of CD276 has been reported in malignant tumors. However, the exact role and mechanisms of CD276 influence the progression of esophageal squamous cell carcinoma (ESCC) still need to be understood. Methods Bioinformatics analysis of data from The Cancer Genome Atlas and Gene Expression Omnibus databases, along with immunohistochemistry staining, was used to explore
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Comparison of trastuzumab emtansine, trastuzumab deruxtecan, and disitamab vedotin in a multiresistant HER2-positive breast cancer lung metastasis model Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-17 Negar Pourjamal, Narjes Yazdi, Aleksi Halme, Vadim Le Joncour, Pirjo Laakkonen, Pipsa Saharinen, Heikki Joensuu, Mark Barok
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External validation of a red cell-based blood prognostic score in patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-16 Michele Maffezzoli, Matteo Santoni, Giulia Mazzaschi, Sara Rodella, Eleonora Lai, Marco Maruzzo, Umberto Basso, Davide Bimbatti, Roberto Iacovelli, Annunziato Anghelone, Ondřej Fiala, Sara Elena Rebuzzi, Giuseppe Fornarini, Cristian Lolli, Francesco Massari, Matteo Rosellini, Veronica Mollica, Cecilia Nasso, Alessandro Acunzo, Enrico Maria Silini, Federico Quaini, Massimo De Filippo, Matteo Brunelli
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Letter: Estimating the baseline local recurrence rate for a brain metastasis after neurosurgical resection Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-14 Joshua S. Suppree, Siddarth Kannan, David M. Hughes, Michael D. Jenkinson, Rasheed Zakaria
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Comparison of ex vivo bioluminescence imaging, Alu-qPCR and histology for the quantification of spontaneous lung and bone metastases in subcutaneous xenograft mouse models Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-14 Marie-Therese Haider, Vera Freytag, Linda Krause, Tanja Spethmann, Tobias Gosau, Mia C. Beine, Christine Knies, Jennifer Schröder-Schwarz, Michael Horn, Kristoffer Riecken, Tobias Lange
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Interrogating the roles of lymph node metastasis in systemic immune surveillance Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-02-05
Abstract Lymph nodes (LNs) are principal orchestrators of the adaptive immune response, yet in the context of malignancy, they are typically the first sites of metastasis. When tumors spread to LNs, they alter the immune repertoire, ultimately reconditioning it in a manner that suppresses anti-tumor immunity and promotes further metastatic dissemination. Conversely, activation of anti-tumor immunity
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Neoadjuvant therapy for resectable melanoma Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-28 Cimarron E. Sharon, Giorgos C. Karakousis
The standard of care for patients with resectable stage III/IV melanoma classically included upfront resection with adjuvant therapy. However, in more recent years, the amount of systemic therapies available for neoadjuvant use for these patients has increased. This article reviewed clinical trials investigating neoadjuvant therapy for patients with resectable stage III/IV melanoma. The outcomes of
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Clinical applications of circulating tumor cells in patients with solid tumors Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-28 Daniel J. Smit, Svenja Schneegans, Klaus Pantel
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Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-23 Cassia Wang, Lee Chen, Doris Fu, Wendi Liu, Anusha Puri, Manolis Kellis, Jiekun Yang
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miRNAs in pancreatic cancer progression and metastasis Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-19 Ellie T. Y. Mok, Jessica L. Chitty, Thomas R. Cox
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Molecular mechanisms of sensitivity and resistance to radiotherapy Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-17 Jessica L. Xing, Baldassarre Stea
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Mapping the single cell spatial immune landscapes of the melanoma microenvironment Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-13 Jamie Magrill, Dan Moldoveanu, Jiayao Gu, Mathieu Lajoie, Ian R Watson
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Axillary nodal staging in breast cancer: what have we learned? Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-13 Theresa L Schwartz
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Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-09
Abstract Glycosylation changes of cancer cells are known to be associated with malignant progression and metastases and potentially determine the organ-selective nature of metastasis as theorized by Paget (Lancet 1:571–573, 1889). Cellular glycans play a variety of roles in the processes of metastasis and may be unique to the cells that metastasize to different organs. We analyzed the glycosylation
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Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-05 Sachin G Nair, Sonu Benny, Wesley M Jose, Aneesh T P
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Acetone compression improves lymph node yield and metastasis detection in colorectal cancer Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-04 Christina Schnoz, Katrin Schmid, Guacimara Ortega Sanchez, Sabina Schacher-Kaufmann, Michel Adamina, Georgios Peros, Dieter Erdin, Peter Karl Bode
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Sentinel lymph nodes in melanoma: necessary as ever for optimal treatment Clin. Exp. Metastasis (IF 4.0) Pub Date : 2024-01-02 Mark B. Faries
Lymphatic metastasis is the dominant route of initial spread for most solid tumors. For many such malignancies, including melanomas, surgical treatment previously included removal of all potentially draining regional lymph nodes (elective node dissection). The advent of lymphatic mapping and sentinel lymph node (SLN) biopsy allowed accurate pathologic assessment of the metastatic status of regional
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Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-23 Margarida Varela dos Santos, Arild Holth, Katharina Bischof, Ben Davidson
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Computational markers for personalized prediction of outcomes in non-small cell lung cancer patients with brain metastases Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-20 Sébastien Benzekry, Pirmin Schlicke, Alice Mogenet, Laurent Greillier, Pascale Tomasini, Eléonore Simon
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Topography and probability diagram of cervical and intra-parotid lymph node metastasis in parotid gland cancer Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-11 Nayeon Choi, Yung Jee Kang, Junhun Cho, Dongryul Oh, Jaewoo Jeong, Han-Sin Jeong
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Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-09 Meret Grube, Arno Dimmler, Anja Schmaus, Rafael Saup, Tabea Wagner, Boyan K. Garvalov, Jonathan P. Sleeman, Wilko Thiele
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Correction to: PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-08 Ying Zhang, Yelong Chen, Chuangzhen Chen, Huancheng Guo, Chunbin Zhou, Hu Wang, Zhaoyong Liu
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Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-08 Wendi Liu, Anusha Puri, Doris Fu, Lee Chen, Cassia Wang, Manolis Kellis, Jiekun Yang
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Management of melanoma: can we use gene expression profiling to help guide treatment and surveillance? Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-08 Jonathan S. Zager, David M. Hyams
Although the incidence of cutaneous melanoma (CM) has been increasing annually, the mortality rate has been decreasing, likely due to better prevention, earlier detection, improved surveillance, and the development of new therapies. Current clinical management guidelines by the National Comprehensive Cancer Network (NCCN) are based on patient risk assignment using staging criteria established by the
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Clinical characteristics, treatment, and outcome of patients with large cell neuroendocrine carcinoma of the lung and brain metastases – data from a tertiary care center Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-12-08 Petar Popov, Ariane Steindl, Ladislaia Wolff, Elisabeth S. Bergen, Franziska Eckert, Josa M Frischer, Georg Widhalm, Thorsten Fuereder, Markus Raderer, Anna S. Berghoff, Matthias Preusser, Barbara Kiesewetter
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The role of host response to chemotherapy: resistance, metastasis and clinical implications Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-11-24 Abhilash Deo, Jonathan P Sleeman, Yuval Shaked
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Comparison of Gamma Knife (GK) and Linear Accelerator (LINAC) radiosurgery of brain metastasis resection cavity: a systematic review and proportional meta-analysis Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-11-09 Rajiv Dharnipragada, Kathryn Dusenbery, Yoichi Watanabe, Clara Ferreira, Clark C. Chen
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The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-11-02 Allison L. Hunt, Imran Khan, Alex M. L. Wu, Sasha C. Makohon-Moore, Brian L. Hood, Kelly A. Conrads, Tamara Abulez, Jonathan Ogata, Dave Mitchell, Glenn Gist, Julie Oliver, Debbie Wei, Monika A. Chung, Samiur Rahman, Nicholas W. Bateman, Wei Zhang, Thomas P. Conrads, Patricia S. Steeg
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Congratulations to Prof. em. Garth L. Nicolson - co-founder of Clinical & Experimental Metastasis. Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-10-21 Jörg Haier,Jonathan Sleeman
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Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-10-16 Anne Huibers, Danielle K. DePalo, Matthew C. Perez, Jonathan S. Zager, Roger Olofsson Bagge
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Cutting-edge innovations in breast cancer diagnosis- the potential of HDMI biomarkers. Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-10-17 Kainat Zahra,Hanzala Ahmed Farooqi
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Development and adaptations of the Graded Prognostic Assessment (GPA) scale: a systematic review Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-10-11 Luana Marques Ribeiro, Fernanda Ferreira Bomtempo, Rebeka Bustamante Rocha, João Paulo Mota Telles, Eliseu Becco Neto, Eberval Gadelha Figueiredo
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High sensitivity flow cytometry immunophenotyping increases the diagnostic yield of malignant pleural effusions Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-10-09 Dolores Subirá, Fabiola Barriopedro, Jesús Fernández, Ruth Martínez, Luis Chara, Jorge Castelao, Eugenia García
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CT-based deep learning model: a novel approach to the preoperative staging in patients with peritoneal metastasis Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-10-05 Jipeng Wang, Yuannan Hu, Hao Xiong, Tiantian Song, Shuyi Wang, Haibo Xu, Bin Xiong
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Etiology and treatment of cancer-related secondary lymphedema Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-09-30 Michael Bernas, Sara Al-Ghadban, Saskia R. J. Thiadens, Karen Ashforth, Walter C. Lin, Bauback Safa, Rudolf Buntic, Michael Paukshto, Alexandra Rovnaya, Margaret L. McNeely
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Associations amongst genes, molecules, cells, and organs in breast cancer metastasis Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-09-09 S. David Nathanson, Lothar C. Dieterich, Xiang H-F. Zhang, Dhananjay A. Chitale, Lajos Pusztai, Emma Reynaud, Yi-Hsuan Wu, Alejandro Ríos-Hoyo
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PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-09-08 Mahdi Zirakchian Zadeh
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Lymphatic trafficking of immune cells and insights for cancer metastasis Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-08-22 David G. Jackson
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Efficacy and safety of thoracic radiotherapy for extensive stage small cell lung cancer after immunotherapy in real world Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-08-16 Min Fang, Le Wang, Qing Gu, Huiwen Wu, Xianghui Du, Xiaojing Lai
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Oncolytic intralesional therapy for metastatic melanoma Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-08-09 Danielle K DePalo, Matthew C. Perez, Anne Huibers, Roger Olofsson Bagge, Jonathan S. Zager
In-transit metastasis (ITM) develop in approximately 1 in 10 patients with melanoma and the disease course can vary widely. Surgical resection is the gold-standard treatment; however, ITM are often surgically unresectable due to size, distribution, and/or anatomic involvement. Oncolytic viral therapies are one category of non-surgical treatment options available for ITM. They induce tumor cell lysis
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Revealing the concealed: A tribute to Donald L. Morton, MD Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-07-31 S. David Nathanson, Ian Wood
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Travelling under pressure - hypoxia and shear stress in the metastatic journey Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-07-25 Ece Su Ildiz, Ana Gvozdenovic, Werner J Kovacs, Nicola Aceto
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Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-07-22 Marcel Mayer, Lisa Nachtsheim, Johanna Prinz, Sami Shabli, Malte Suchan, Jens Peter Klußmann, Alexander Quaas, Christoph Arolt, Philipp Wolber
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Prognostic impact of EGFR/ALK alterations in leptomeningeal metastasis from lung adenocarcinoma treated with whole-brain radiotherapy Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-07-19 Hidekazu Oyoshi, Hidenari Hirata, Yasuhiro Hirano, Sadamoto Zenda, Yuzheng Zhou, Kento Tomizawa, Takeshi Fujisawa, Masaki Nakamura, Hidehiro Hojo, Atsushi Motegi, Shun-Ichiro Kageyama, Yoshitaka Zenke, Koichi Goto, Shunichi Ishihara, Shinji Naganawa, Tetsuo Akimoto
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Association between primary tumor characteristics and histopathological growth pattern of liver metastases in colorectal cancer Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-07-15 Ali Bohlok, Camille Tonneau, Sophie Vankerckhove, Ligia Craciun, Valerio Lucidi, Fikri Bouazza, Alain Hendlisz, Jean Luc Van Laethem, Denis Larsimont, Peter Vermeulen, Vincent Donckier, Pieter Demetter
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‘Sandwich treatment’ for posterior fossa brain metastases with volume larger than 4cm3: a multicentric retrospective study Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-07-13 Zheng Wang, Haining Chen, Qun Chen, Yucun Zhu, Min Li, Zhou Jia
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Clinical relevance of biomarker discordance between primary breast cancers and synchronous axillary lymph node metastases Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-07-01 Slavica Janeva, Toshima Z. Parris, Ellen Krabbe, Marie Sundquist, Per Karlsson, Riccardo A. Audisio, Roger Olofsson Bagge, Anikó Kovács
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EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-06-28 Xiaoting Song, Xu Cheng, Xiangang Jin, Shengyu Ruan, Xianquan Xu, Feng Lu, Xinhui Wu, Fangying Lu, Mingxuan Feng, Liwei Zhang, Renshan Ge, Haixiao Chen, Zhenghua Hong, Dun Hong
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Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-06-16 Mikaela M. Mallin, Nicholas Kim, Mohammad Ikbal Choudhury, Se Jong Lee, Steven S. An, Sean X. Sun, Konstantinos Konstantopoulos, Kenneth J. Pienta, Sarah R. Amend
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Platycodin D represses β-catenin to suppress metastasis of cetuximab-treated KRAS wild-type colorectal cancer cells Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-06-16 Yongming Lv, Wenhong Wang, Yanfei Liu, Ben Yi, Tianhao Chu, Zhiqiang Feng, Jun Liu, Xuehua Wan, Yijia Wang
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Effect of liver metastasis on the efficacy of immune checkpoint inhibitors in cancer patients: a systemic review and meta-analysis Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-06-13 Bao-Wen Tian, Cheng-Long Han, Han-Chao Wang, Lun-Jie Yan, Zi-Niu Ding, Hui Liu, Xin-Cheng Mao, Jin-Cheng Tian, Jun-Shuai Xue, Long-Shan Yang, Si-Yu Tan, Zhao-Ru Dong, Yu-Chuan Yan, Dong-Xu Wang, Tao Li
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LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-06-02 Jiao Guan, Zheng-Yun Zhang, Jian-Hua Sun, Xin-Ping Wang, Zun-Qiang Zhou, Lei Qin
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Clinical characteristics, treatment, and long-term outcome of patients with brain metastases from thyroid cancer Clin. Exp. Metastasis (IF 4.0) Pub Date : 2023-05-23 Ladislaia Wolff, Ariane Steindl, Petar Popov, Karin Dieckmann, Brigitte Gatterbauer, Georg Widhalm, Anna Sophie Berghoff, Matthias Preusser, Markus Raderer, Barbara Kiesewetter