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Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention Indian J. Pharmacol. (IF 2.4) Pub Date : 2024-03-08 Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. AIM: The aim of this study was to find out the safety, adverse reactions, and long-term effectiveness of Pistacia lentiscus plant extract (mastic gum) in diabetic gastroparesis (DG) with respect to sustainable improvement in gastroparesis symptoms (Gastrointestinal Cardinal Symptom Index [GCSI] score) by observational
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Development of Alpha-Synuclein protein model against therapeutic aspects of Parkinson’s disease Indian J. Pharmacol. (IF 2.4) Pub Date : 2024-03-08 Kanika Bhardwaj, Neelu Kanwar Rajawat, Nupur Mathur
Parkinson’s disease (PD) is the most common neurodegenerative disease caused by the steady depletion of dopamine in the striatum due to the loss of dopaminergic neurons. Most of the current therapeutics work on rebuilding the striatal dopamine level through oral administration of levodopa which stops the symptoms of PD. But there is a long-term motor complication with these dopamine precursors. Moreover
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Cosmeceuticals: A transit state from synthetic to natural Indian J. Pharmacol. (IF 2.4) Pub Date : 2024-03-08 Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati
Cosmeceuticals are topically applied cosmetic products containing a biologically active ingredient with a pharmaceutical effect that improves, nourishes, and treats the skin appearance. The trend of cosmeceuticals began during the mid-20th century due to its potent ingredients with therapeutic effects for various skin ailments. Even though there is a great advancement in cosmetics, which shows the
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Fixed drug combination (levosulpiride and rabeprazole)-induced atypical Parkinsonian’s disorders with associated anxiety and low-lying depression Indian J. Pharmacol. (IF 2.4) Pub Date : 2024-03-08 Vishal R. Tandon, Sheikh Hanan Ismail, Amarjeet Singh
We hereby describe a rare case of levosulpiride-induced atypical parkinsonism presenting with sluggish movements, atypical kinetic tremors (tremors with voluntary movement), periorbital tremors, dystonia, difficulty in speech and coordination, postural imbalance, with additional features of difficulty in swallowing and drooling with associated recent onset psychiatric disturbances such as anxiety and
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Investigation of the Asyogh’s rectangular device for learning and memory testing in Wistar rats Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-12-27 Yogesh Chand Yadav
This study aimed to design Asyogh’s rectangular device that is used for memory testing in rodents. It was found that scopolamine (3 mg/kg i.p.) and diazepam (1 mg/kg i.p.) caused significant memory deficits in rats, as evidenced by increased transfer latency times. However, these memory deficits were significantly reversed when the rats were pretreated with Donepezil. It further demonstrates that pretreated
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Tongue and teeth hyperpigmentation in etoposide, prednisolone, vincristine, and cyclophosphamide regimen in the treatment of cutaneous lymphoma Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-12-27 Soumya Shivalingappa Morabad, Zahed Ullah Khan, Richa Gad, Nikitha Kallur, Irappa Vithoba Madhabhavi, Mallappa Hanumanthappa Shalavadi, Chandrashekhar Venkaraddi Mangannavar
Cutaneous extranodal non-Hodgkin lymphoma is a rare cancer and chemotherapeutic agents like etoposide, vincristine and cyclophosphamide are the drug of choice, which rarely cause hyperpigmentation in skin and nails. However, herein we present a case of hyperpigmentation that was seen in tongue and even in teeth. The hyperpigmentation of the tongue and teeth occurred shortly after the initiation of
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A comprehensive review on traditional applications, phytochemistry, pharmacology, and toxicology of Thymus serpyllum Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-12-27 Deeksha Salaria, Rajan Rolta, Uma Ranjan Lal, Kamal Dev, Vikas Kumar
Thymus serpyllum L. from the Lamiaceae family is an underexplored perennial medicinal shrub with traditional usage in treating respiratory and gastrointestinal issues in the upper foothills of India. This review aims to provide a comprehensive assessment of current knowledge concerning the traditional uses, phytochemistry, and pharmacology of T. serpyllum. The primary objective is to collect updated
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Comparative evaluation of efficacy and tolerability of apremilast and methotrexate in patients of moderate-to-severe palmoplantar psoriasis: A randomized, parallel, open-label clinical trial Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-12-27 Mitali Wagh, Jayesh Mukhi, Smita Sontakke, Amit Dhok, Avinash Turankar, Mrunalini Kalikar
BACKGROUND: Variable results about efficacy as well as safety of apremilast compared to methotrexate are reported in different trials. Hence, it is necessary to collect more evidence to prove the role of Apremilast in palmoplantar psoriasis. METHODOLOGY: The study was a randomized, prospective, parallel-group, open-label study conducted in patients with moderate-to-severe palmoplantar psoriasis.
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Extensive arm skin necrosis following administration of unfractionated heparin Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-11-02 Dena Firouzabadi, Peyman Petramfar, Laleh Mahmoudi
Unfractionated heparin (UH), a commonly used anticoagulant, can rarely cause skin necrosis following heparin-induced thrombocytopenia (HIT). A 38-year-old female, a case of chronic inflammatory demyelinating polyneuropathy (CIDP) admitted to the neurology ward, developed extensive skin necrosis following a change in UH dose at the exact site of UH injection. A sudden fall in the platelet count was
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Drug repurposing a compelling cancer strategy with bottomless opportunities: Recent advancements in computational methods and molecular mechanisms Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-11-02 Rasmita Dash, Madhulika Yadav, Jyotirmaya Biswal, Shrabani Samanta, Tripti Sharma, Sujata Mohapatra
Drug discovery has customarily focused on a de novo design approach, which is extremely expensive and takes several years to evolve before reaching the market. Discovering novel therapeutic benefits for the current drugs could contribute to new treatment alternatives for individuals with complex medical demands that are safe, inexpensive, and timely. In this consequence, when pharmaceutically yield
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Efficacy, safety, and dose-response effects of calcifediol supplementation on 25-hydroxyvitamin D, parathyroid hormone, and 1,25-dihydroxyvitamin D levels in healthy adults: An open-label, interventional pilot study Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-11-02 Liza Das, Michael F. Holick, Naresh Sachdeva, Sanjay Kumar Bhadada, Shallu Singhmar, Neetika Thakur, Pinaki Dutta, Raman Kumar Marwaha
BACKGROUND: Vitamin D deficiency (VDD) is highly prevalent across the globe. Cholecalciferol (Vitamin D3) fails to attain sufficient serum concentrations of 25-hydroxyvitamin D (25(OH)D) in a significant proportion of supplemented individuals. Calcifediol (25-hydroxyvitamin D3) is less studied in healthy adults and its effects on 25(OH)D, parathyroid hormone (PTH), and 1,25-dihydroxyvitamin D (1,25(OH)2D)
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Toxicity of zinc alone or its formulation: An issue that needs attention. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Sumanpreet Kaur,Dibyajyoti Banerjee
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Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 J Kumaravel,Harvinder Singh,Sukhmeet Kaur,Ajay Prakash,Bikash Medhi
Novel SARS-CoV-2 (COVID-19) is affecting worldwide as declared pandemic by the WHO. Various repositioning and novel therapeutic agents are being evaluated under different clinical setups; however, there is no promising therapeutic agent reported to date. Small molecules like peptides have their popularity as their specificity, delivery, and synthesizability as promising therapeutic agents. In this
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Efficacy and safety of levamisole in childhood nephrotic syndrome: A meta-analysis. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Girish Chandra Bhatt,Bhupeshwari Patel,Rashmi Ranjan Das,Shikha Malik,Martin Bitzan,Nihar Ranjan Mishra
Present evidence regarding the efficacy and safety of levamisole in childhood nephrotic syndrome (NS), particularly the steroid-sensitive NS (SSNS), is limited. We searched relevant databases such as PubMed/MEDLINE, Embase, Google Scholar, and Cochrane CENTRAL till June 30, 2020. We included 12 studies for evidence synthesis (5 were clinical trials that included 326 children). The proportion of children
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Successful management of delayed hyaluronidase hypersensitivity after subtenon's anesthesia during the COVID-19 pandemic: A rare case report. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Bharat Gurnani,Kirandeep Kaur
Subtenon's block is commonly used to achieve akinesia, analgesia, and anesthesia for ophthalmic surgeries. This case study detailed a rare hypersensitivity report in a 65-year-old female who had underwent manual small incision cataract surgery under subtenon's anesthesia (STA) in the left eye. On postoperative day 1, she presented with acute onset proptosis, periorbital edema, conjunctival chemosis
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Nutrivigilance - The need of the hour. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Harshad Malve,Madeline Fernandes
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Nephroprotective potential of syringic acid in experimental diabetic nephropathy: Focus on oxidative stress and autophagy. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Bhoomika Sherkhane,Veera Ganesh Yerra,Anjana Sharma,K Anil Kumar,Gundu Chayanika,Arruri Vijay Kumar,Ashutosh Kumar
BACKGROUND Diabetic nephropathy (DN) is a chronic hyperglycemic manifestation of microvascular damage in the kidneys. Widespread research in this area suggests the involvement of perturbed redox homeostasis and autophagy in renal cells phrase- promote the progression of DN. MATERIALS AND METHODS Reframed sentences-The present study investigates the pharmacological effect of Syringic acid (SYA), in
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Comparison of clinical effect of octreotide and pituitrin in treatment of upper gastrointestinal hemorrhage in cirrhosis. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Yanli Zhu,Yihua Ren,Chunmei Li,Zhaoming Si,Nannan Chi
OBJECTIVE The objective of the study was to compare and observe the therapeutic effect of octreotide and pituitrin in upper gastrointestinal hemorrhage caused by cirrhosis. MATERIALS AND METHODS In this prospective, randomized, open, single-blind, controlled, and single-center study, patients with upper gastrointestinal hemorrhage induced by cirrhosis were divided into control group (treated with pituitrin)
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Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Meha P Mehta,Normi D Gajjar,Rutvi J Patel,Lipi P Joshi,Gaurang B Shah
OBJECTIVE Human cytochrome p450 enzymes play an important role in the metabolism of various substances. The CYP2C subfamily consists of various important drug-metabolizing enzymes such as CYP2C9 and CYP2C19. The objectives of the study include the determination of the frequency of genetic variants (CYP2C9*2, CYP2C9*3, and CYP2C19*2) of selected enzymes using allele-specific polymerase chain reaction
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Comparison of patients using lamivudine, entecavir, and tenofovir according to liver fibrosis markers fibrosis-4 and aspartate aminotransferase-to-platelet ratio index scores. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Huseyin Dogus Okan,Oguz Karabay,Ertugrul Guclu,Mustafa Baran Inci,Aziz Ogutlu
OBJECTIVES It was intended to assess the efficacy of lamivudine, entecavir, and tenofovir regimens in the management of chronic hepatitis B (CHB) guided by Fibrosis-4 (FIB-4) and aspartate aminotransferase-to-platelet ratio index (APRI) scores. MATERIALS AND METHODS Our study was conducted on patients who applied to the hepatitis outpatient clinic between 2008 and 2015 retrospectively. Lamivudine,
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Efficacy and safety analysis of prucalopride in refractory chronic constipation cases in a tertiary care hospital in Eastern India: A randomized, single-blind, placebo-controlled study. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Suhasini Dehury,Sourya Mohapatra,Haribhakti Seba Das,Siddhartha Goutam,Chetna Kaushik
OBJECTIVES Chronic constipation (CC), a common functional gastrointestinal disorder, has laxatives as its mainstay of treatment. Refractoriness to laxatives calls for better treatment options. Prucalopride is a novel, well-tolerated enterokinetic with high 5-hydroxytryptamine 4 receptor selectivity. This study was undertaken with the intention to establish the efficacy and safety of prucalopride with
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Concept of essential medicines and recent updates. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Shreya Gupta,J Kumaravel,Ajay Prakash,Bikash Medhi
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Baboon syndrome with lactulose: An apparently inert drug causing a systemic reaction. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Diksha Agrawal,Pooja Arora
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Pharmacovigilance study of amphotericin B for mucormycosis in post-COVID and non-COVID patients at a tertiary care hospital in Eastern India. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Suparna Chatterjee,Manjari Bhattacharjee,Avijit Hazra,Pradip Mukhopadhyay,Biman Kanti Ray,Sayan Chatterjee,Souvik Dubey
BACKGROUND Mucormycosis is a rare but serious fungal infection which has dramatically increased in post-COVID patients. There is a paucity of safety data on amphotericin B (amphoB) used for mucormycosis treatment. OBJECTIVES The objective of this prospective, observational, active safety surveillance study was to evaluate the safety profile of amphoB in a cohort of hospitalized patients who were on
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An idiosyncratic reaction of unilateral common peroneal nerve palsy associated with below desired therapeutic range of tacrolimus level in a patient postheart transplantation. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Ayush Srivastava,P Ansuman Abhisek,Shweta Supriya Pradhan
Tacrolimus (TAC) is a very effective medication in routine use after solid organ transplantation. The potential, but infrequently reported neurological adverse effect of TAC is peripheral neuropathy (PN). This has rarely been reported in heart transplant patients. To the best of our knowledge, the data regarding mononeuropathy of common peroneal nerve presented with foot drop due to low whole blood
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Translational research: Bridging the gap between preclinical and clinical research. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Vidya Mahalmani,Shweta Sinha,Ajay Prakash,Bikash Medhi
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Intradermal versus intramuscular COVID-19 vaccination aiming at protection for delta variant: cost utility analysis. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Rujittika Mungmunpuntipantip,Viroj Wiwanitkit
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Evaluation of mechanism(s) of action underlying the antioxidant and antiulcer activity of Sesamum indicum leaves extract in experimental rats. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Shivam,Phool Chandra,Neetu Sachan
OBJECTIVE The current study aimed to estimate phytochemical screening, in vitro antioxidant activity, and gastroprotective activity of Sesamum indicum Linn ethanolic extract. MATERIALS AND METHODS The current study was held out by ulceration induced by pylorus ligation and indomethacin-induced ulcer screening models in Wister albino rats. The screening of antiulcer activity of ethanolic extract of
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Paxlovid: A promising drug for the challenging treatment of SARS-COV-2 in the pandemic era. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Niraj Niraj,Sonia Shinde Mahajan,Ajay Prakash,Phulen Sarma,Bikash Medhi
Coronavirus infection is a pandemic threat and the most dangerous disease of the 21st century. Despite the rigorous exertion of world-class researchers, there is no perfect cure for it. It has been seen in presently available studies that Paxlovid prevents the progression of diseases and reduces severity in patients tremendously who are at high risk of hospitalization and death. It is a safe oral antiviral
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Pharmacological treatment of bipolar disorder in pregnancy: An update on safety considerations. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Swarndeep Singh,Raman Deep
Pregnancy in women with bipolar disorder (BD) can be considered a high-risk pregnancy in view of several clinical and pharmacotherapeutic considerations. Pharmacological treatment during pregnancy requires a careful weighing of psychotropic drug exposure against the risk of BD relapse. An untreated bipolar illness can negatively affect the health of mother as well as unborn child in the event of a
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Lasmiditan abortive therapy for episodic migraine in Phase II/III randomized clinical trials: A meta-analysis. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Marya Ahsan,Ayaz Khurram Mallick
OBJECTIVE Although migraine is common, there are very few treatment options. Recently, lasmiditan, a specific 5-HT1F agonist, has gained approval as abortive therapy for migraine. This meta-analysis and trial sequential analysis (TSA) was performed to analyze efficacy and tolerability of lasmiditan therapy for episodic migraine. MATERIALS AND METHODS Phase II and Phase III double-blinded placebo-controlled
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Use of drugs not listed in the National List of Essential Medicines: Findings from a prescription analysis by the Indian Council of Medical Research-Rational Use of Medicines Centres Network in tertiary care hospitals across India. Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Ratinder Jhaj,Aditya Banerjee,Nilima Arun Kshirsagar,Balakrishnan Sadasivam,Sujith J Chandy,Heber Rew Bright,Preetha Kaur Chugh,C D Tripathi,Dinesh Kumar Badyal,Madhulika Peter Samuel,Bikash Medhi,Ajay Prakash,Rupa Joshi,Sandhya Kamat,Raakhi Tripathi,Urwashi Indrakumar Parmar,Harihar Dikshit,Hitesh Mishra,Sukalyan Saha Roy,Niyati Trivedi,Janki Chauhan,Suparna Chatterjee,Manjari Bhattacharya,Chetna
BACKGROUND The concept of listing essential medicines can lead to improved supply and access, more rational prescribing, and lower costs of drugs. However, these benefits hinge on the prescription of drugs from an Essential Medicines List (EML). Several studies have highlighted the problem of underutilization of EMLs by prescribers. Therefore, as part of prescription research by the Indian Council
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Virtual screening and molecular dynamics simulation study of approved drugs as a binder to the linoleic acid binding site on spike protein of SARS-CoV-2 and double mutant (E484Q and L452R). Indian J. Pharmacol. (IF 2.4) Pub Date : 2022-01-01 Manisha Prajapat,Phulen Sarma,Nishant Shekhar,Arushi Chauhan,Gurjeet Kaur,Anusuya Bhattacharyya,Pramod Avti,Gajendra Choudhary,Seema Bansal,Saurabh Sharma,Hardeep Kaur,Subodh Kumar,Harvinder Mann,Anupam Raja,Ashutosh Singh,Rahul Singh,Amit Raj Sharma,Ajay Prakash,Bikash Medhi
INTRODUCTION Binding of linoleic acid (LA) to the spike trimer stabilizes it in closed conformation hindering its binding to angiotensin-converting enzyme-2, thus decreasing infectivity. In the current study, we tend to repurpose Food and Drug Administration-approved drugs as binder to the LA binding pocket in wild and double mutant spike protein. MATERIALS AND METHODS Approved drugs from DrugBank
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Long coronavirus disease: Consequences of COVID-19 infection and vaccine on cardiovascular diseases. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Krishna Tiwari,Aswini Saravanan,Abhishek Anil,Surjit Singh,Shoban Babu Varthya
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Annual ivermectin treatment, interferon-gamma, and responsiveness to monkeypox infection. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Rujittika Mungmunpuntipantip,Viroj Wiwanitkit
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Deferasirox causing duodenal ulcer leading to upper gastrointestinal bleed and hemorrhagic shock in a child with beta-thalassemia major. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Anu Tresa,Guruprasad Hassan Shankar,Bhakti U Sarangi,Ajay Walimbe
Iron chelators have significantly reduced the morbidity associated with iron overload and improved the quality of life in children with beta-thalassemia major. A 5-year-old female child with beta-thalassemia major on recurrent transfusions and oral chelation with deferasirox was brought with repeated episodes of frank hematemesis and progressive lethargy. Her evaluation revealed anemia, leukocytosis
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Baseline predictors of genital mycotic infections following sodium-glucose cotransporter-2 inhibitors initiation in men with type 2 diabetes. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Mainak Banerjee,Ayan Mukherjee,Avijit Hazra,Satinath Mukhopadhyay
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Plasma drug concentration resulting from body surface area-based dosage. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Heng Wang,Song Xue
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The effect of protocatechuic acid on neuropathic pain and possible mechanism. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Melda Ozgurbuz Cici,Nurcan Bektas
OBJECTIVES The goal of the research is to investigate the protocatechuic acid (PCA) potential action, a phenolic acid derivative, on pain induced by neuropathy and to determine its efficacy on activation of KATP type channels and A1 receptors. MATERIALS AND METHODS Neuropathic pain by cause of sciatic nerve damage was induced in Sprague-Dawley rats. Anti-allodynic and anti-hyperalgesic effects were
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A nude mutant rat derived from Sprague Dawley-National Institute of Nutrition rat colony with normal thymus: A potential model for noncommunicable diseases. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Satyavani Motha,Pradeep Bhatu Patil,Ravindar Naik Ramavat,Srinivas Myadara,S S Y H Qadri
BACKGROUND A spontaneous mutant rat with a hairless phenotype and an intact thymus was discovered in a long-standing Sprague Dawley-National Institute of Nutrition (SD/NIN) rat colony at a national animal resource facility. OBJECTIVE We conducted extensive phenotypic and biochemical analyses on this mutant strain to determine its suitability as a preclinical model for immunocompetent testing in noncommunicable
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Study of fingolimod, nitric oxide inhibitor, and P-glycoprotein inhibitor in modulating the P-glycoprotein expression via an endothelin-sphingolipid pathway in an animal model of pharmacoresistant epilepsy. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Nitika Garg,Rupa Joshi,Alka Bhatia,Seema Bansal,Amitava Chakrabarti,Ajay Prakash,Biman Saikia,Manish Modi,Bikash Medhi
BACKGROUND The overexpression of P-glycoprotein (P-gp) contributes to drug resistance in patients with epilepsy, and the change of P-gp expression located at the blood-brain barrier alienates the anti-seizure effects of P-gp substrates. Thus, the present study explored the effect of fingolimod (FTY720) acting through an endothelin-sphingolipid pathway on P-gp-induced pentylenetetrazol (PTZ)-kindled
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Cost-minimization analysis of escitalopram, fluoxetine, and amitriptyline in the treatment of depression. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Harshit Hemant Salian,M V Raghav,Vikram Singh Rawat,A Divakar
INTRODUCTION Escitalopram, fluoxetine, and amitriptyline are the drugs commonly used in the treatment of depression. The pharmacoeconomic evaluation of these drugs becomes relevant as they are prescribed for a long period of time, and depression causes a significant economic burden. The cost-minimization study would contribute to bringing down the annual treatment costs, leading to better medication
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Space medicine: Hunting for pharmacologist's guide in dealing with drugs in microgravity. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Vidya Mahalmani,Bikash Medhi
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Fixed drug eruption - Experience from a tertiary care center in Uttarakhand. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Neirita Hazarika,Puneet Dhamija,Amrita Upadhyaya,Manisha Rauthan
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Testing the knowledge and interpretation skills of ChatGPT in pharmacology examination of phase II MBBS. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Anitha Elango,Neevedha Kannan,Isswariya Anandan,Krishna Mohan Surapaneni
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A case series on tofacitinib-induced weight gain. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Kanisha Shah,Dhaiwat Shukla,Manish Patel,Supriya Malhotra
Janus kinase inhibitor tofacitinib belongs to a group of targeted synthetic disease-modifying anti-rheumatic drugs, also known as small molecule inhibitors. They are oral drugs with a novel strategy to treat inflammatory diseases. The major concern with the use of these drugs is a high risk for infections and other potential side effects. Here, we have focused on reporting one of the rare side effects
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Overview of the National Ethics Committee Registry for Biomedical and Health Research in India: Stepping up to safeguard the ethical aspect of research involving human participants. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Balu Venugopal,Anu Nagar,Yogesh Kumar,Sujata Sinha
As notified in the New Drugs and Clinical Trials Rules 2019, ethics committees (ECs), intending to review and oversee the conduct of Biomedical and Health Research (BHR) shall be required to register with the authority designated by the Central Government in the Ministry of Health and Family Welfare, Department of Health Research (DHR). The entire process of receiving and processing such applications
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Protective effects of ginsenosides in cisplatin-induced kidney injury: A systematic review, meta-analysis. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Xinyi Luo,Dengpiao Xie,Ziwei Chen,Qing Ji
Although evidence suggests ginsenosides, the primary active and distinctive components of ginseng, have beneficial effects in cisplatin-induced nephrotoxicity, their efficacy and protective mechanisms remain unclear. The aim of the current meta-analysis is to study the effectiveness and mechanisms of ginsenosides in a model of nephrotoxicity induced by cisplatin. Preclinical investigations were conducted
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Genomic biomarkers: Unveiling the potential for precise cancer therapy response. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Gurjeet Kaur,Paras Pahwa,Ajay Prakash,Bikash Medhi
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Potential use of Balanophora latisepala (V. Tiegh.) Lec. extract for the treatment of diabetes. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Nguyen Trong Hong Phuc,Nguyen Thi Yen Lan,Nguyen Van Ay
INTRODUCTION Balanophora latisepala (BL) is a chlorophyll-free and obligate parasitic plant found across mountainous areas of An Giang, Vietnam. This study was conducted to evaluate the effectiveness of extracts from BL, herbs mentioned in many traditional medicines in the treatment of diabetes, on laboratory mice. MATERIALS AND METHODS The effects of BL aqueous, methanol, and ethanol extracts on the
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Pharmacovigilance in the medical education: In UG curriculum where do we stand? What can be done? Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Shiva Murthy Nanjundappa,Pratibha Durgesh Nadig,M K Jayanti,R M Veena,G N Manjunath
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Citicoline on the Barthel Index: Severe and moderate brain injury. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Mehdi Mahmoodkhani,Bahram Aminmansour,Mehdi Shafiei,Mohammadreza Hasas,Donya Sheibani Tehrani
INTRODUCTION Traumatic brain injury (TBI) is a paramount factor in mortality and morbidity. The clinical trials conducted to investigate the efficacy of neuroprotective agents, such as citicoline, as a therapeutic alternative for TBI have presented divergent findings. Therefore, this study aimed to evaluate and compare citicoline's effect on the Barthel Index in patients with severe and moderate brain
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Colistin versus polymyxin B: A pragmatic assessment of renal and neurological adverse effects and effectiveness in multidrug-resistant Gram-negative bacterial infections. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Veneta Simon,Aathira Viswam,Pallavi Sarah Alexander,Emmanuel James,S Sudhindran
OBJECTIVES Our study aimed to evaluate the real-world data on renal and neurological adverse effects and effectiveness of colistimethate sodium (CMS) and polymyxin B (PMB). MATERIALS AND METHODS An observational prospective study was performed on inpatients receiving CMS and PMB for multidrug-resistant Gram-negative bacterial infections. CMS dose was titrated to renal function, and serum creatinine
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Role of vascular endothelial growth factor in tuberculous meningitis: A prospective study from a tertiary care center in North India. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Devesh Kumar,Deependra Singh,Tanish Modi,Riya Sharma,Anand Keshav Awasthy,Ritu Shree,Manoj Kumar Goyal,Dhawal Narang,Siddharth Chand,Sameer Vyas,Kusum Sharma,Navneet Sharma,Rudresh Gowda,Abeer Goel,Rajeev Ranjan,Manish Modi
INTRODUCTION The status of vascular endothelial-derived growth factor (VEGF) in the pathogenesis of tuberculous meningitis (TBM) remains far from clear. We prospectively evaluated the role of serum and cerebrospinal fluid (CSF) VEGF in TBM. PATIENTS AND METHODS This prospective study was conducted at a tertiary care center in North India from January 2018 to June 2019. Consecutive drug-naive patients
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Genetic polymorphisms of microsomal epoxide hydrolase and UDP-glucuronosyltransferase (UGT) and its effects on plasma carbamazepine levels and metabolic ratio in persons with epilepsy of South India: A cross-sectional genetic association study. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Shravan Venkatraman,Kesavan Ramasamy,Pradeep Pankajakshan Nair
OBJECTIVES Carbamazepine (CBZ), an anti-seizure drug, is widely prescribed for the management of focal seizures. At a given therapeutic dose, CBZ exhibits marked interindividual variation in the plasma CBZ levels. The aim wasto study the influence of EPHX1 c.337 T>C and UGT2B7*2 genetic polymorphisms on plasma carbamazepine (CBZ) levels in persons with epilepsy (PWE) from South India. METHODS 115 PWE
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A prospective study to assess the role of paraoxonase 1 genotype and phenotype on the lipid-lowering and antioxidant activity of statins. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Charuta Godbole,Saket Thaker,Santosh Salagre,Vyankatesh Shivane,Nithya Gogtay,Urmila Thatte
Human paraoxonase 1 (PON1) enzyme protects against atherosclerosis by preventing low-density lipoprotein from oxidative modification. Upregulation of PON1 enzymatic activity is suggested to contribute to atheroprotective potential of statins. Glutamine (Q) to arginine (R) at site 192 and leucine (L) to methionine (M) substitution at site 55 polymorphisms influence the PON1 activity. The study assessed
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Carpal tunnel syndrome ascribed to low-dose combined oral contraceptive pills. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Deepthi Yedla,Sharmila Vijayan,Thirunavukkarasu Arun Babu
Carpal tunnel syndrome (CTS) is the most prevalent compressive focal mononeuropathy brought on by median nerve compression, and common manifestations include pain in the wrist joint, decreased sensations along the distribution of the median nerve, a reduction in two-point discrimination, nighttime awakening, and, in more advanced stages, thenar muscle wasting and weakening. CTS, although common, yet
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Concurrent administration of COVID-19 vaccine and seasonal influenza vaccine: No increased estimated vaccine-related mortality rate. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Pathum Sookaromdee,Viroj Wiwanitkit
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Kratom (Mitragyna speciosa) and COVID-19: How about the current evidence? Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Amnuay Kleebayoon,Viroj Wiwanitkit
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Clinical trials for food - The gray areas: Developing countries' perspective. Indian J. Pharmacol. (IF 2.4) Pub Date : 2023-01-01 Praisy K Prabha,Ajay Prakash,Bikash Medhi