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The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse J. Nat. Med. (IF 3.3) Pub Date : 2024-03-18
Abstract Non-alcoholic steatohepatitis (NASH) is a progressive fibrotic form of non-alcoholic fatty liver disease. Liver fibrosis leads to liver cancer and cirrhosis, and drug therapy for NASH remains lacking. Ninjin’yoeito (NYT) has shown antifibrotic effects in a model of liver fibrosis without steatosis but has not been studied for NASH. Therefore, we evaluated the efficacy of NYT in mice fed a
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Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV–XVII J. Nat. Med. (IF 3.3) Pub Date : 2024-03-08 Masateru Ono, Daiki Tenmaya, Maki Tarumi, Syouri Satou, Kotone Tsuji, Hirotaka Nishikawa, Shin Yasuda, Hiroyuki Miyashita, Jian-Rong Zhou, Kazumi Yokomizo, Hitoshi Yoshimitsu, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo
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Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway J. Nat. Med. (IF 3.3) Pub Date : 2024-03-03
Abstract Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentraxin 3 (PTX3) is highly expressed in the serum of patients with LN. Renal PTX3 deposition is directly related to clinical symptoms such as proteinuria and inflammation. The excessive proliferation of mesangial cells (MCs) is one of the representative pathological changes
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Cycloartane-type triterpenoids from the leaves of Sandoricum koetjape and their efficacy on α-glucosidase inhibition activity J. Nat. Med. (IF 3.3) Pub Date : 2024-03-01 Tai-Xuan-Hoa Hang, Suekanya Jarupinthusophon, Rita Hairani, Van-Kieu Nguyen, Warinthorn Chavasiri
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Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments J. Nat. Med. (IF 3.3) Pub Date : 2024-03-01 Xin Fang, Yaoxuan Ji, Shuang Li, Lei Wang, Bo He, Bo li, Boshen Liang, Hongke Yin, Haotian Chen, Duojie Dingda, Bing Wu, Fabao Gao
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Identification of Angelica acutiloba, A. sinensis, and other Chinese medicinal Apiaceae plants by DNA barcoding J. Nat. Med. (IF 3.3) Pub Date : 2024-03-01 Motoyasu Minami, Ryusaku Tanaka, Takako Mori, Taichi Fujii, Takashi Tsuchida
Crude drug Angelicae acutilobae radix is one of the most important crude drugs in Japanese traditional medicine and is used mainly for the treatment of gynecological disorders. In the listing in the Japanese Pharmacopoeia XVIII, Angelicae acutilobae radix is defined as the root of Angelica acutiloba (Apiaceae), which has long been produced on an industrial scale in Japan. With the aging of farmers
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A new linear peptide, higapeptin, isolated from the mud flat-derived fungus Acremonium persicinum inhibits mitochondrial energy metabolism J. Nat. Med. (IF 3.3) Pub Date : 2024-02-29 Ahmed H. El-Desoky, Yuki Hitora, Yoshitomo Nishime, Yusaku Sadahiro, Teppei Kawahara, Sachiko Tsukamoto
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Screening of growth inhibitors for epithelial–mesenchymal transition-induced cells by TGF-β from plant-based sources identified the active compound hydroxychavicol from Piper bitle J. Nat. Med. (IF 3.3) Pub Date : 2024-02-29
Abstract Epithelial–mesenchymal transition (EMT) has recently been associated with cancer invasion, metastasis, and resistance. In our previous study, we discovered nanaomycin K, a natural growth inhibitor for EMT-induced Madin Darby canine kidney (MDCK) cells, from the cultured broth of actinomycetes. However, the screening method was undeveloped, because the activity of nanaomycin K was discovered
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Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation J. Nat. Med. (IF 3.3) Pub Date : 2024-02-26 Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu
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Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo J. Nat. Med. (IF 3.3) Pub Date : 2024-02-25
Abstract Betulinic acid (BA), a naturally occurring lupane-type triterpenoid, possesses a wide range of potential activities against different types of cancer. However, the molecular mechanisms involved in anti-cervical cancer about BA were rarely investigated. Herein, the role of BA in cervical cancer suppression by ROS-mediated endoplasmic reticulum stress (ERS) and autophagy was deeply discussed
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Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo J. Nat. Med. (IF 3.3) Pub Date : 2024-02-14 Yan Luo, Jiaxing Zhang, Yue Jiao, Hao Huang, Liangshan Ming, Yunlei Song, Yanlong Niu, Xiaolu Tang, Liwei Liu, Yi Li, Yumao Jiang
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Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus J. Nat. Med. (IF 3.3) Pub Date : 2024-02-12 Yusuke Hirasawa, Ayaka Kase, Akie Okamoto, Keigo Suzuki, Mizuki Hiroki, Toshio Kaneda, Nahoko Uchiyama, Hiroshi Morita
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Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway J. Nat. Med. (IF 3.3) Pub Date : 2024-02-09 Chong Gao, Zhong-He Hu, Zhen-Yu Cui, Yu-Chen Jiang, Jia-Yi Dou, Zhao-Xu Li, Li-Hua Lian, Ji-Xing Nan, Yan-Ling Wu
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Evodiamine inhibits growth of vemurafenib drug-resistant melanoma via suppressing IRS4/PI3K/AKT signaling pathway J. Nat. Med. (IF 3.3) Pub Date : 2024-02-07 Xingxian Guo, Shiying Huang, Yonghong Zhang, Hong Wang, Lisha Li, Jianhua Ran, Dilong Chen, Xiaopeng Li, Jing Li
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Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7 J. Nat. Med. (IF 3.3) Pub Date : 2024-01-24 Takahiro Kitagawa, Takahiro Matsumoto, Tomoe Ohta, Tatsusada Yoshida, Youhei Saito, Yuji Nakayama, Yuki Hadate, Eishi Ashihara, Tetsushi Watanabe
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Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability J. Nat. Med. (IF 3.3) Pub Date : 2024-01-24
Abstract Chemotherapy is still a prevalent strategy for clinical lung cancer treatment. However, the inevitable emerged drug resistance has become a great hurdle to therapeutic effect. Studies have demonstrated that the primary cause of drug resistance is a decrease in the chemotherapeutic medicine concentration. Several lectins have been confirmed to be effective as chemotherapy adjuvants, enhancing
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Study on the mechanism of Panax notoginseng–Salvia miltiorrhiza herb pair on invigorating blood circulation and eliminating blood stasis by blocking the conversion of arachidonic acid to prostaglandin J. Nat. Med. (IF 3.3) Pub Date : 2024-01-23
Abstract We combined untargeted and targeted metabolomics to explore the mechanism of blood circulation and blood stasis activation in the traditional Chinese herb pair Panax notoginseng–Salvia miltiorrhiza (PS). In this study, the right hind limb of SD rats was struck by a 1 kg weight, causing traumatic blood stasis (TBS) model, then the rats were gavaged with PS (at ratios of 1:0, 0:1, 3:1, 1:1,
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Revision of NMR assignment for Morin-3-O-glucoside and microbial production of Morin-2’-O-glucoside J. Nat. Med. (IF 3.3) Pub Date : 2024-01-18 Muhammad Fitrah, Syatirah Djalaluddin, Zhichao Wang, Kana Nishida, Hideaki Otsuka, Katsuyoshi Matsunami
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Improved quantitative analysis of tenuifolin using hydrolytic continuous-flow system to build prediction models for its content based on near-infrared spectroscopy J. Nat. Med. (IF 3.3) Pub Date : 2024-01-04 Tatsuki Kitazoe, Chisato Usui, Eiichi Kodaira, Takuro Maruyama, Noriaki Kawano, Hiroyuki Fuchino, Kazuhiko Yamamoto, Yasushi Kitano, Nobuo Kawahara, Kayo Yoshimatsu, Tatsuya Shirahata, Yoshinori Kobayashi
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Akebia saponin D attenuates allergic airway inflammation through AMPK activation J. Nat. Med. (IF 3.3) Pub Date : 2024-01-04
Abstract Akebia saponin D (ASD) is a bioactive triterpenoid saponin extracted from Dipsacus asper Wall. ex DC.. This study aimed to investigate the effects of ASD on allergic airway inflammation. Human lung epithelial BEAS-2B cells and bone marrow-derived mast cells (BMMCs) were pretreated with ASD (50, 100 and 200 μΜ) and AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) (1 mM)
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Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity J. Nat. Med. (IF 3.3) Pub Date : 2023-12-28 Seung-U Son, Hee Won Lee, Ju-Hyeon Park, Kwang-Soon Shin
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Kaempferol-3-O-(2″-O-galloyl-β-d-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia—induced brain injury J. Nat. Med. (IF 3.3) Pub Date : 2023-12-24 Loan Thanh Thi Nguyen, Xoan Thi Le, Ha Thi Nguyen, Tai Van Nguyen, Hang Nguyet Thi Pham, Anh Van Thi Pham, Kinzo Matsumoto
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Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs J. Nat. Med. (IF 3.3) Pub Date : 2023-12-22 Katsuko Komatsu
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Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation J. Nat. Med. (IF 3.3) Pub Date : 2023-12-11 Yue Fei, Xiaoyan Zhang, Xiaohui Wang, Yifei Sun, Jin He, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianming Liu, Huilai Zhang, Xianhuo Wang
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Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway J. Nat. Med. (IF 3.3) Pub Date : 2023-12-08 Yu Shimada, Motofumi Kumazoe, Yushi Otsuka, Rin Tetsuzen, Yoshinori Fujimura, Hirofumi Tachibana
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Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics J. Nat. Med. (IF 3.3) Pub Date : 2023-11-30 Gang Zou, Ruihong Yu, Dezhang Zhao, Zhaohui Duan, Shimin Guo, Tingting Wang, Limei Ma, Zhiyi Yuan, Chao Yu
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Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells J. Nat. Med. (IF 3.3) Pub Date : 2023-11-28 Hiroko Miyagishi, Ami Joyama, Hiroshi Nango, Koume Nagayama, Minoru Tsuji, Hiroshi Takeda, Yasuhiro Kosuge
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Kamikihito reduces β-amyloid25–35-induced axon damage via neurotrophic factors J. Nat. Med. (IF 3.3) Pub Date : 2023-11-27 Takumi Nagamatsu, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki
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Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors J. Nat. Med. (IF 3.3) Pub Date : 2023-11-22 La-or Somsakeesit, Thanaset Senawong, Gulsiri Senawong, Pakit Kumboonma, Arunta Samankul, Narissara Namwan, Chavi Yenjai, Chanokbhorn Phaosiri
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Three-membered ring formation catalyzed by α-ketoglutarate-dependent nonheme iron enzymes J. Nat. Med. (IF 3.3) Pub Date : 2023-11-19 Richiro Ushimaru
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Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver J. Nat. Med. (IF 3.3) Pub Date : 2023-11-16 Akifumi Nagatomo, Mamiko Kohno, Hirosato Kawakami, Yoshiaki Manse, Toshio Morikawa
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Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine J. Nat. Med. (IF 3.3) Pub Date : 2023-11-11 Takao Hirai, Wei Wang, Naoko Murono, Kazuo Iwasa, Makoto Inoue
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Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens J. Nat. Med. (IF 3.3) Pub Date : 2023-11-06 Linda Sukmarini, Akhirta Atikana, Triana Hertiani
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The marine Penicillium sp. GGF16-1-2 metabolite dicitrinone G inhibits pancreatic angiogenesis by regulating the activation of NLRP3 inflammasome J. Nat. Med. (IF 3.3) Pub Date : 2023-10-28 Zhimian Shi, Minyi Zhang, Hao Fan, Yijun Chen, Su Dong, Fengguo Zhou, Bin Wang, Jingya Liu, Jiaqi Jin, Yong Luo, Qiuhe Chen, Wei Wang, Cuixian Zhang, Yang Chen
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Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway J. Nat. Med. (IF 3.3) Pub Date : 2023-10-10 Tengyang Ni, Zewen Chu, Li Tao, Yang Zhao, Mengying Lv, Miao Zhu, Yuanyuan Luo, Masataka Sunagawa, Haibo Wang, Yanqing Liu
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Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation J. Nat. Med. (IF 3.3) Pub Date : 2023-10-12 Yan Luo, Jiaxuan Hu, Yue Jiao, Liwei Liu, Dan Miao, Yunlei Song, Wenjing Yan, Yi Li, Yumao Jiang
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2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs J. Nat. Med. (IF 3.3) Pub Date : 2023-10-07 Kuniko Kusama-Eguchi, Yuki Tokui, Ai Minoura, Yuta Yanai, Dai Hirose, Megumi Furukawa, Yasuhiro Kosuge, Motofumi Miura, Emika Ohkoshi, Mitsuko Makino, Kimino Minagawa, Keiichi Matsuzaki, Yoshio Ogawa, Kazuko Watanabe, Ayumi Ohsaki
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Highly sensitive indirect competitive enzyme-linked immunosorbent assay based on a monoclonal antibody against saikosaponin b2 for quality control of Kampo medicines containing Bupleuri radix J. Nat. Med. (IF 3.3) Pub Date : 2023-10-07 Akihiro Ochi, Shunsuke Fujii, Tomoe Ohta, Takuhiro Uto, Poomraphie Nuntawong, Hiroyuki Tanaka, Satoshi Morimoto, Seiichi Sakamoto
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Ligustilide enhances pregnancy outcomes via improvement of endometrial receptivity and promotion of endometrial angiogenesis in rats J. Nat. Med. (IF 3.3) Pub Date : 2023-09-12 Dongjie He, Yanli Song, Huidongzi Xiao, Shaoqi Shi, Hongyan Song, Tianwei Cui, Tingting Ni, Jing Wang, Xingxing Ren, Aiwu Wei
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Genetic diversity of Panax ginseng cultivated in Japan and its relation with some plant characteristics J. Nat. Med. (IF 3.3) Pub Date : 2023-09-14 Honoka Ito, Michiho Ito
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Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata J. Nat. Med. (IF 3.3) Pub Date : 2023-09-15 Lingjian Tan, Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Di Zhou, Ning Li, Li Huang, Chin-Ho Chen, Wei Li
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Ceramicines U–Z from Chisocheton ceramicus and structure–antimalarial activity relationship study J. Nat. Med. (IF 3.3) Pub Date : 2023-09-10 Alfarius Eko Nugroho, Tomoyuki Komuro, Takuya Kawaguchi, Yusuke Shindo, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, A. Hamid A. Hadi, Hiroshi Morita
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Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells J. Nat. Med. (IF 3.3) Pub Date : 2023-09-05 Mizuki Hiroki, Aishanjiang Abulikemu, Chihiro Totsuka, Yusuke Hirasawa, Toshio Kaneda, Hiroshi Morita
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Allicin ameliorates sepsis-induced acute kidney injury through Nrf2/HO-1 signaling pathway J. Nat. Med. (IF 3.3) Pub Date : 2023-09-05 Xiao-Jun Li, Ting Liu, Yuan Wang
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Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells J. Nat. Med. (IF 3.3) Pub Date : 2023-09-01 Masaya Okayama, Takahiro Matsumoto, Takahiro Kitagawa, Seikou Nakamura, Tomoe Ohta, Tatsusada Yoshida, Tetsushi Watanabe
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Euchronin A–F isolated from the Arnebia euchroma (Royle) Johnst. and their anti-proliferative activities in vitro J. Nat. Med. (IF 3.3) Pub Date : 2023-09-01 Zhen-Peng Zhang, Yan Liu, Hai-Dan Zou, Juan Pan, Zhi-Chao Hao, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang, Bing-You Yang
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Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models J. Nat. Med. (IF 3.3) Pub Date : 2023-08-19 Shao-Yang Zhao, Huan-Huan Zhao, Bao-Hua Wang, Cui Shao, Wen-Jun Pan, Sai-Mei Li
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Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood J. Nat. Med. (IF 3.3) Pub Date : 2023-08-19 Hiroyuki Morita, Yuan-E Lee, She-Po Shi
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Hydrophobic constituents of Polygonum multiflorum roots promote renal erythropoietin expression in healthy mice J. Nat. Med. (IF 3.3) Pub Date : 2023-08-16 Saki Shirako, Siti Mariyah Ulfa, Yuto Nishidono, Dinia Rizqi Dwijayanti, Tetsuya Okuyama, Richi Nakatake, Ken Tanaka, Yukinobu Ikeya, Mikio Nishizawa
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Population genetic structure of wild Angelica acutiloba, A. acutiloba var. iwatensis, and their hybrids by atpF–atpA intergenic spacer in chloroplast DNA and genome-wide SNP analysis using MIG-seq J. Nat. Med. (IF 3.3) Pub Date : 2023-08-15 Motoyasu Minami, Ryusaku Tanaka, Takako Mori, Taichi Fujii, Takashi Tsuchida, Toshiro Shibata
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Simplified detection of the species of origin of antler velvets using single-stranded tag hybridization chromatographic printed-array strip J. Nat. Med. (IF 3.3) Pub Date : 2023-08-14 Hiroaki Nakanishi, Aya Takada, Katsumi Yoneyama, Kentaro Sakai, Kazuyuki Saito
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Metabolite profiling of Drynariae Rhizoma using 1H NMR and HPLC coupled with multivariate statistical analysis J. Nat. Med. (IF 3.3) Pub Date : 2023-08-03 Yuzhuo Dong, Kazufumi Toume, Shin Kimijima, Hanpei Zhang, Shu Zhu, Yumin He, Shaoqing Cai, Takuro Maruyama, Katsuko Komatsu
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Publisher Correction: New biofunctional effects of oleanane-type triterpene saponins J. Nat. Med. (IF 3.3) Pub Date : 2023-08-03 Hisashi Matsuda, Toshio Morikawa, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa
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Quantitative analysis of taxiphyllin, a cyanogenic glycoside, in the leaves of Hydrangea macrophylla var. thunbergii J. Nat. Med. (IF 3.3) Pub Date : 2023-07-30 Junko Tsukioka, Yutaro Ohki, Momona Nakao, Seikou Nakamura
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A monoacylglyceryltrimethylhomoserine, 21F121-A, containing a branched acyl group from Penicillium glaucoroseum J. Nat. Med. (IF 3.3) Pub Date : 2023-07-29 Ichiro Kimura, Yuki Hitora, Yusaku Sadahiro, Teppei Kawahara, Sachiko Tsukamoto
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Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity J. Nat. Med. (IF 3.3) Pub Date : 2023-07-29 Xue Han, Li-Hua Liu, Xiao-Ying Fang, Shu-Tai Jiang, Huan Zhao, Zheng-Ming Qian, Zhi-Nan Yin, Li-Gong Lu, Chuan-Xi Wang, Xin-Sheng Yao, Hao Gao
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Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation J. Nat. Med. (IF 3.3) Pub Date : 2023-07-25 Li Li, Jia-Min Dong, He-He Ye, Man-Jing Jiang, Huan-Hua Yang, Lin-Pan Liang, Li-Jun Ning, Ying Wu
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Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes J. Nat. Med. (IF 3.3) Pub Date : 2023-07-18 Nhat Nam Hoang, Takeshi Kodama, Yu Nakashima, Kiep Minh Do, Saw Yu Yu Hnin, Yuan-E Lee, Prema, Naotaka Ikumi, Hiroyuki Morita
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Four new stilbenes and one new flavonoid with potential antibacterial and anti-SARS-CoV-2 activity from Cajanus cajan J. Nat. Med. (IF 3.3) Pub Date : 2023-07-18 Jia-Yan Chen, Xin Lian, Yu-Wen Fan, Zhuo-Yi Ao, Wei-Jie Zhang, Yong-Chen Pan, Li-Ping Chen, Jie Yuan, Jie-Wei Wu
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Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.) J. Nat. Med. (IF 3.3) Pub Date : 2023-07-14 Naoko Masumoto, Takumi Ohno, Toshihiro Suzuki, Tadayasu Togawa, Naoki Sugimoto