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Regulatory impact of statins on macrophage polarization: mechanistic and therapeutic implications J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-03-12 Mahvash Sadeghi, Shaho Khayati, Sajad Dehnavi, Wael Almahmeed, Vasily N Sukhorukovi, Amirhossein Sahebkar
Statins, also known as HMG-CoA reductase inhibitors, are widely prescribed drugs for the prevention and treatment of cardiovascular diseases. In addition to their lipid-lowering effects, these compounds have been found to possess immune-modulating properties. Macrophages, which are crucial phagocytic cells in the body, can be divided into two main subsets: M1 (proinflammatory) and M2 (anti-inflammatory)
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Δ(9)-tetrahydrocannabinol protects cardiac tissue against endoplasmic reticulum and oxidative stresses, apoptosis, and inflammation in rats with hyperinsulinemia J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-03-12 Zeynep Mine Coskun Yazici, Karolin Yanar, Sema Bolkent
Objectives In our study, we aimed to examine how δ(9)-tetrahydrocannabinol (THC) administration to hyperinsulinemia (HI) model rats would change endoplasmic reticulum stress (ERS), apoptosis, inflammation, and oxidative stress in cardiac tissue. Methods Rats were divided into four groups (n = 32): Control (C), THC, HI, and Treatment (Tre). Fructose (10%) in the drinking water was given to HI and Tre
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Rosemary essential oil potentiates the antitumour activity of 5-fluorouracil in human colorectal carcinoma cells J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-03-09 Amine Ali El Sala, Ghada Khawaja, Mahmoud Khalil, Sherine Abdel Salam
Objectives Improving response rates in colorectal cancer (CRC) is an urgent clinical need. This study aimed to explore the synergistic action of Lebanese rosemary essential oil (REO) and 5-fluorouracil (5-FU) in HCT116 CRC cells. Methods We tested the cell viability of monotherapy and combination therapy. The combination index was calculated using CompuSyn software to evaluate drug–drug interactions
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Phillyrin improves myocardial remodeling in salt-sensitive hypertensive mice by reducing endothelin1 signaling J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-03-06 Qingman Luo, Qiao Liu, Kecheng Tang, Bin Zhong, Shengqian Yang, Xiaohui Li
Objectives Prolonged exposure to chronic hypertension places the heart under excessive strain, resulting in myocardial remodeling. Phillyrin, derived from the natural plant Forsythia suspensa, has been found to possess cardioprotective properties. The objective of this study is to investigate the role and mechanism of phillyrin in hypertension-induced myocardial remodeling in mice. Methods We constructed
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1H-NMR-based metabolomics to dissect the traditional Chinese medicine promotes mesenchymal stem cell homing as intervention in liver fibrosis in mouse model of Wilson’s disease J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-03-02 Ying Ma, Yuancheng Bao, Han Wang, Huaizhou Jiang, Lei Zhou, Bo Yang, Xiaofeng Huang, Wenming Yang, Daojun Xie, Juan Zhang
Background We administered Bushen Huoxue Huazhuo Formula (BSHXHZF) and transplanted bone marrow mesenchymal stem cells (BMSCs) into mice with Wilson’s disease (WD)-related liver fibrosis to evaluate the liver-protecting mechanism of this prescription. Methods Mice, randomly divided into different treatment groups, showed histopathological changes and degree of hepatocyte apoptosis. For hepatic hydroxyproline
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Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-29 Xueqiang Chen, Chunhong Liu, Jiaxin Deng, Taibao Xia, Xiaohai Zhang, Shuangtao Xue, Meng-Ke Song, Opeyemi Joshua Olatunji
Objectives Schisandrin B (Sch B) has been shown to possess anti-inflammatory and antioxidant properties, however, its antirheumatoid arthritis properties and potential mechanism remain unexplored. This study evaluated the potential of Sch B in adjuvant-induced arthritic (AIA) rats. Methods AIA was induced by injecting 0.1 ml of CFA into the paw of rats and the animals were administered with Sch B (50
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Preparation of glycyrrhizic acid-modified BSA-nanoparticles and evaluation of their hepatic cellular distribution J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-25 Hongping Tang, Xinyu Qiu, Yue Chen, Li Yan, Jie Zhao, Bing tao Cao, Yujing He, Jifu Hao
Objectives Orientation to specific cells is an important topic in active targeting strategy for nanoparticle-based drug delivery systems. While these administered nanoparticles will be sequestrated within the liver, their cellular distribution behaviors in the liver are not clear. The aim of this study was to fabricate glycyrrhizic acid (GL) modified BSA nanoparticles and evaluate their hepatic cellular
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Brusatol’s anticancer activity and its molecular mechanism: a research update J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-23 Wenyi Xi, Chenhui Zhao, Zeyu Wu, Tongtong Ye, Rui Zhao, Xiaochun Jiang, Shizhang Ling
Objective Brusatol (BT) is a quassinoid compound extracted from Brucea javanica that is a traditional Chinese herbal medicine. Brusatol possesses biological and medical activity, including antitumor, antileukemia, anti-inflammatory, antitrypanosomal, antimalarial, and antitobacco mosaic virus activity. To summarize and discuss the antitumor effects of BT and its mechanisms of actions, we compiled this
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Integration of pharmacodynamics and metabolomics to reveal rhubarb anthraquinone protection against nonalcoholic fatty liver disease rat model J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-13 Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xiaohong Gong, Yunxia Li
Objectives The objective of the present study was to investigate the effect of Rhubarb anthraquinone (RA) on a high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) rat model, and explore potential biomarker and metabolic pathways by using the metabolomics method. Materials and methods We established HFD rats as the NAFLD model. Forty Sprague–Dawley rats were randomly divided into a
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Protective effects of piperlongumine against adjuvant-induced arthritis in rats through modulating OPG/RANKL/NF-κB signaling pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-09 Sheng-dong Wu, Xin-jie Wu, Tian-tian Wang, Fei Jiang, Ming-wang Hu, Rong Li, Ji Liu, Li Cai
Objectives We examined the antirheumatoid effects of piperlongumine (PLM) on rat adjuvant-induced arthritis (AIA) and explored the underlying mechanisms involved. Methods PLM (2.5, 5, and 10 mg/kg) was administered intraperitoneally to AIA rats to assess its effectiveness. Blood, thymus, spleen, ankle joint, and synovial tissue samples were gathered for subsequent analyses, like enzyme-linked immunosorbent
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Celastrus orbiculatus extract reverses precancerous lesions of gastric cancer by inhibiting autophagy via regulating the PDCD4-ATG5 signaling pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-09 Fangyuan Zhu, Xiaoze Zhang, Junsong Wen, Yanqing Liu, Yaodong Zhu
Objectives Celastrus orbiculatus ethyl acetate extract (COE) is the main extract of the stem of the Chinese herbal C. orbiculatus, which has anti-tumor and anti-inflammatory biological effects. Our previous study showed that COE had a certain reversal effect on the precancerous lesions of gastric cancer (PLGC) in rats, but the exact mechanism of action remains elusive. We aimed to explore the therapeutic
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Ganoderic acid A suppresses autophagy by regulating the circFLNA/miR-486-3p/CYP1A1/XRCC1 axis to strengthen the sensitivity of lung cancer cells to cisplatin J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-08 Enhui Gong, Jiongwei Pan, Zaiting Ye, Xiaoping Cai, Hao Zheng, Zhangyong Yin, Yiwei Jiang, Xin Wang, Zhuo Cao
Objectives Reportedly, ganoderic acid A (GA-A) increases the sensitivity of hepatocellular carcinoma cells to cisplatin (DDP) chemotherapy. Therefore, this study aims to fathom the influence of GA-A on lung cancer cells. Methods After the construction of A549/DDP cells through exposure to DDP, the effects of GA-A on A549 and A549/DDP cells were revealed by cellular functional assays, western blot and
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Chrysin bonded to β-d-glucose tetraacetate enhances its protective effects against the neurotoxicity induced by aluminum in Swiss mice J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-02-08 Victor Ifeanyi Okoh, Hericles Mesquita Campos, Pâmela Yasmin de Oliveira Ferreira, Robbert Mota Pereira, Yohanny Souza Silva, Evilanna Lima Arruda, Barbara Pagliarani, Gerlon de Almeida Ribeiro Oliveira, Luciano Morais Lião, Gabriel Franco dos Santos, Boniek Gontijo Vaz, José Ricardo Sabino, Fernanda Cristina Alcantara dos Santos, Elson Alves Costa, Andrea Tarozzi, Ricardo Menegatti, Paulo César Ghedini
Objectives To evaluate whether the glycosylation of chrysin (CHR) enhances its protective effects against aluminum-induced neurotoxicity. Methods To compare the antioxidant, anticholinesterase, and behavioral effects of CHR with its glycosylated form (CHR bonded to β-d-glucose tetraacetate, denoted as LQFM280), we employed an integrated approach using both in vitro (SH-SY5Y cells) and in vivo (aluminum-induced
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Sanshimao formula inhibits the hypoxia-induced pro-angiogenesis of hepatocellular carcinoma cells partly through regulating MKK6/p38 signaling pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-30 Zhe Chen, Man Wang, Xiang Lv, Yannan Xu, Xionghui Wang, Bai Li, Changquan Ling, Juan Du
Objectives Sanshimao (SSM) is a traditional Chinese medicine formula for advanced hepatocellular carcinoma (HCC). This study was designed to investigate the effect of SSM on HCC-induced angiogenesis and to explore the potential mechanism. Methods The endothelial cells were cultured with HCC cells conditioned medium in the 1% oxygen atmosphere to imitate tumor hypoxia microenvironment. EA.hy926 cells
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Investigation of polysaccharide from Radix Aconiti Lateralis Preparata (Fuzi) cardio protective effect on doxorubicin-induced chronic cardiotoxicity J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-30 Fang Xiong, Lin Pu, Daibo Wang, Fu Peng, Luyao Sun, Qian Yu, Xiaofang Xie, Cheng Peng
Objectives Doxorubicin (DOX) is a chemotherapy drug for treating malignant tumours. However, its cardiotoxicity has limited its clinical application. The Radix Aconiti Lateralis Preparata, also known as Fuzi, has been used for treating heart failure. Nevertheless, there is still a deficiency of claeity as to whether the Fuzi polysaccharide (FPS) may prevent the side effects of DOX. Methods Mice were
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Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-27 Acharya Balkrishna, Ashwani Kumar, Akansha Rohela, Vedpriya Arya, Ajay Kumar Gautam, Hemant Sharma, Priyanka Rai, Amita Kumari, Ryszard Amarowicz
Objectives Despite significant advancements in modern medicine, effective hepatoprotective medication with minimal side effects is still lacking. In this context. Tinospora cordifolia, an Indian Ayurvedic liana, has attracted much attention. Key findings Traditionally, T. cordifolia has been found to be effective in the treatment of jaundice; according to the literature, T. cordifolia is a hepatoprotective
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Fructose aggravates copper-deficiency-induced cardiac remodeling by inhibiting SERCA2a J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-25 Yi Xu, Qiuxia Xu, Zhirui Zheng, Xin Jiang, Yuansen Shi, Yipu Huang, Yun Liu
Objectives Accumulating evidence demonstrates that copper deficiency (CuD) is a risk factor for cardiovascular diseases, besides, fructose has been strongly linked to the development of cardiovascular diseases. However, how CuD or fructose causes cardiovascular diseases is not clearly delineated. The present study aims to investigate the mechanism of CuD or fructose on cardiac remodeling. Methods We
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Exploring various measures of the area under the curve for the assessment of dose-proportionality and estimation of bioavailability J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-24 Dion R Brocks, Elisabeth A Minthorn, Brian E Davies
Objective In pharmacokinetics, the area under the concentration versus time curve (AUC) extrapolated to infinity (AUC0−∞) is the preferred metric but it is not always possible to have a reliable estimate of the terminal phase half-life. Here we sought to explore the accuracy of three different area measures to accurately identify dose proportionality and bioavailability. Methods One to three compartment
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Phloretin: a comprehensive review of its potential against diabetes and associated complications J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-20 Vishwadeep Shelke, Ajinath Kale, Yogesh A Kulkarni, Anil Bhanudas Gaikwad
Objectives Phloretin is ubiquitous in apples (Malus domestica) and other fruits and has potential antidiabetic properties. Considering the preclinical potential of phloretin, its transition to clinical observations has unintentionally been neglected, particularly within the diabetic population. Furthermore, a comprehensive understanding of its pharmacokinetics remains elusive. This review seeks to
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Oligo/polysaccharides from Cyathula officinalis and Achyranthes bidentata: a review of structures and bioactivities J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-20 Jun-Hong Chai, Ting-Ting He, Si-Liang Jiang, Xin-Hua Zhu, Qing-Yu Zhang, Ming-Chi Ji, Jun Liang, Yong-Gang Xia
Objectives Oligo-/polysaccharides from Cyathula officinalis Kuan (COPs) and Achyranthes bidentata Blume (ABPs) have attracted researchers’ attention in the fields of healthy food supplements and traditional Chinese medicine (Niúxī) due to their multiple bioactivities combined with their nontoxic and highly biocompatible nature. The purpose of this paper was to provide a systematic and comprehensive
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Fat mass and obesity-associated protein inhibit the pathology of rheumatoid arthritis through the NSUN2/SFRP1/Wnt/β-catenin signal axis J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-20 Yurong Huang, Pengfei Xu, Faxue Liao, Huibo Ca, Xiaomei Wang, Xiao Wang, Jun Chang, Chenggui Miao
Objectives The purpose of this study is to investigate whether fat mass and obesity-associated protein (FTO) and NOL1/NOP2/Sun domain family member 2 (NSUN2) mediated RNA methylation is associated with RA pathology. Methods We studied the anti-rheumatoid arthritis (RA) mechanism mediated by FTO and NSUN2 in RA samples and collagen-induced arthritis (CIA) rats using real time qPCR (RT-qPCR), western
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Solanine induces ferroptosis in colorectal cancer cells through ALOX12B/ADCY4 molecular axis J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-20 Xudong Ma, Yijun Li, Daoming Liang, Fan Jiang, Lu Zhang, Wanhong Song, Baosheng Wan, Chuqi Xia, Qiyu Lu
Objectives Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer worldwide. Solanine is a phytochemical extracted from traditional Chinese medicine with widely reported anticancer effects. Here, we investigated the potential role of solanine in regulating ferroptosis in CRC cells and scrutinized the molecular mechanism. Methods Cell growth and cytotoxicity were examined using CCK-8 proliferation
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Ethyl 2,2-difluoro-2-(2-oxo-2H-chromen-3-yl) acetate attenuates the malignant biological behaviors of non-small cell lung cancer via suppressing EGFR/PI3K/AKT/mTOR signaling pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-19 Liyi Zou, Xiaodan Li, Jiansuo Lin, Xuehong Fang, Jie Lin, Lu Zhang, Yan Zhang, Yanwen Liang, Jianwei Ren, Yi Liu, Zunnan Huang
Objective The goal of the study is to examine the impact on the malignant biological behaviors of non-small cell lung cancer (NSCLC) of a novel coumarin derivative, ethyl 2,2-difluoro-2-(2-oxo-2H-chromen-3-yl) acetate (C2F). It also aims to define its underlying mechanism. Methods NSCLC cell lines and xenograft nude mice model were conducted to explore the anti-NSCLC effects of C2F in vitro and in
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Ling-Gui-Zhu-Gan decoction protects against doxorubicin-induced myocardial injury by downregulating ferroptosis J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-19 Ya-li Yang, Chuan-zhi Zhao, Chun-chun Zhao, Zhong-yu Wen, Yao-yao Ma, Xiao-ni Zhao, Liang Wang, Jin-ling Huang, Peng Zhou
Objective To investigate the mechanism of Ling-Gui-Zhu-Gan decoction (LGZGD) protects against doxorubicin (DOX)-induced myocardial injury. Methods In vivo experiment, rats were divided into six groups: normal group, model group (15 mg/kg, DOX), Dex group(150 mg/kg, Dex), LGZGD-L group (2.1 g/kg), LGZGD-M group (4.2 g/kg), and LGZGD-H group (8.4 g/kg). We used HE and Masson staining to observe the histopathological
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Examination of Hibiscus sabdariffa’s bioactive arsenal: pharmacological prospects and comprehensive insights into catalysing health and wellness through its therapeutic attributes—an exposition J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-16 Saurabh Dilip Bhandare, Sarika Shivaji Malode
This study signifies the rich pharmacological potential of Hibiscus sabdariffa, exploring its bioactive components and their therapeutic implications for health and wellness. Despite the promising insights, a comprehensive critical analysis is essential to ensure scientific rigour. To address this, the study establishes clear aims and objectives, aiming to scrutinise the study findings through a meticulous
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Puerarin alleviates diabetic nephropathy by inhibiting Caspase-1-mediated pyroptosis J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-12 QiuYan Chen, Lu Wang, Xiaojie Wei, Ming Chen, Xiaoping Zhang, Rou Mo, Renbin Huang, Tao Liang, Xiaohui Xu
Background and purpose Diabetic nephropathy (DN) is an important cause of end-stage renal disease, with podocyte injury as the main feature. Pyroptosis plays a non-negligible role in the process of diabetic nephropathy. Puerarin (PR) treatment of diabetic nephropathy has great potential, but the mechanism is not very clear. This article aims to study the protective effect and mechanism of puerarin
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Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-12 Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu
Imperatorin (IMP) is the main bioactive furanocoumarin of Angelicae dahuricae radix, which is a well-known traditional Chinese medicine. The purpose of this study was to elucidate the role of IMP in promoting absorption and the possible mechanism on the compatible drugs of Angelicae dahuricae radix. The influence of IMP on drugs’ intestinal absorption was conducted by the Caco-2 cell model. The mechanism
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Biochemical changes to the inner ear contributing to diabetes-induced hearing loss: possible pharmacological targets for therapy J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-11 Ahmed Gedawy, Hani Al-Salami, Crispin R Dass
Objectives Biochemical alterations due to diabetes development and progress are complex and diabetes-associated injury to various tissues has been well reported. Nevertheless, a close investigation of the literature demonstrates limited coverage regarding these biochemical and molecular alterations within the inner ear and their impact on the vestibulocochlear environment. A closer look at these may
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Natural products derived from herbs as promising source for diarrhea predominant-irritable bowel syndrome via gut microbiota–serotonin pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-10 Mengmeng Zhang, Ming Dang, Yao Li, PeiFeng Wei, Chongbo Zhao, Taiwei Dong
Objective Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, with diarrhea predominant IBS (IBS-D) as the most common subtype. Increasing evidence reported that the gut microbiota-mediated serotonin pathway plays a crucial role in the pathogenesis of IBS-D. In this study, potential herbal medicine, plant extracts and its monomers that can be employed as the candidate
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Si-Zhi Wan regulates osteoclast autophagy in osteoporosis through the AMPK signaling pathway to attenuate osteoclastogenesis J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-06 Yucheng Huang, Huan Yao, Adi Wirawan Tjahjono, Li Xiang, Ke Li, Jiahe Tang, Yongxiang Gao
Objectives The mechanisms underlying the therapeutic effects of Si-Zhi Wan (SZW), a traditional Chinese medicine used to treat osteoporosis (OP), remain unknown. This study investigated the therapeutic effects of SZW on mice that underwent ovariectomy (OVX) and underlying mechanisms thereof. Methods We established an in vivo model of OP by performing OVX in mice. Microcomputed tomography (Micro-CT)
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Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Duhuo–Jisheng pair against osteoarthritis J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-06 Haiyang Kou, Jianbing Ma
Objective The Duhuo–Jisheng pair is the ruling herb in Duhuo Jisheng decoction, which is a classic formula first recorded in the preparedness and urgency of the thousand jewels. Methods We obtained the primary constituents of Duhuo–Jisheng and their associated protein targets from the TCMSP database. We constructed a composite target network using Cytoscape 3.9.1. To identify potential targets for
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3-Demethyl-2-geranyl-4-prenylbellidifoline, a natural xanthone with diuretic and kidney protective properties J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2024-01-02 Luísa Nathália Bolda Mariano, Thaise Boeing, Valdir Cechinel Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza
Objectives The diuretic and kidney protective effect of the 3-demethyl-2-geranyl-4-prenylbellidifoline (DGP) were evaluated in rats. Methods The normotensive (NTR) and spontaneously hypertensive rats (SHR) received, once a day for 7 days, oral treatment with DGP (0.1 mg/kg), hydrochlorothiazide (10 mg/kg), or vehicle (10 ml/kg). Urine, blood, and kidney samples were collected for further analysis.
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Comparison of capecitabine concentrations determined by microsampling versus plasma concentrations for therapeutic drug monitoring: a pilot study J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-12-23 Mohsen Shafiei, Peter Galettis, Philip Beale, Jennifer H Martin, Andrew J McLachlan, Prunella Blinman
Objectives Therapeutic drug monitoring allows personalized dosing of chemotherapy, but is not well established for capecitabine. The aim of this study was to compare the concentrations of capecitabine and its metabolites obtained simultaneously by microsampling with plasma sampling and their acceptability to patients. Methods Adults taking capecitabine for cancer had paired (duplicate) microsampling
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Engineering carrier nanoparticles with biomimetic moieties for improved intracellular targeted delivery of mRNA therapeutics and vaccines J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-12-14 Matteo Puccetti, Marilena Pariano, Aurelie Schoubben, Maurizio Ricci, Stefano Giovagnoli
Biological membrane-engineered lipid nanoparticles (LNP) have shown enormous potential as vehicles for drug delivery due to their outstanding biomimetic properties. To make these nanoparticles more adaptable to complex biological systems, several methods and cellular sources have been adopted to introduce biomembrane-derived moieties onto LNP and provide the latter with more functions while preserving
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Differential effects of dietary polyphenols on oral pharmacokinetics of cyclin-dependent kinase inhibitors in rats: a mechanistic framework for in vitro–in vivo extrapolation J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-12-12 Prajakta Harish Patil, Mrunal Pradeep Desai, Sumit Birangal, G Gautham Shenoy, Jagadish Puralae Channabasavaiah
Objectives Cyclin-dependent kinase inhibitors are subject to rapid first-pass metabolism, and their oral absorption is hindered by intestinal CYP3A4 and P-gp. The present study investigates the impact of dietary polyphenols on the oral pharmacokinetics of palbociclib and ribociclib, considering their potential as modulators of CYP3A4 and P-gp. Methods Therefore, potential inhibitory effects of dietary
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The effect of patient’s body weight, infusion connection point, and infusion pump position on intravenous multi-infusion drug delivery at low infusion rates suitable for premature neonates J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-12-02 Kamelia Krysiak, Brian Cleary, Naomi McCallion, Fiona O’Brien
Introduction Parenteral drug administration in the neonatal intensive care involves complex pharmacotherapy adjusted for the patient’s weight, fluid allowance, and complex multi-infusion systems. Objectives We investigated the delivery rate of a model drug through a multi-infusion system consisting of six intravenous infusions. Methods Delivery rate of the model drug was determined after infusion initiation
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Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-26 Wanli Jin, Samantha J Stehbens, Ross T Barnard, Mark A T Blaskovich, Zyta M Ziora
Objectives The co-occurrence of melanoma and Parkinson’s disease (PD) is higher than expected. We review the relationship between melanoma and PD, then proffer a hypothesis of how dysregulated human tyrosinase could be involved in both diseases via the loss of dopamine and neuromelanin-positive neurons in PD and the genesis alterations in melanin content during melanoma. Key findings There are a surprising
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Thyme extract could overcome diabetes-induced reproductive dysfunction by inhibiting oxidative damage and increasing the expression of insulin receptor substrate and pyruvate kinase in the rat sperm J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-26 Mahdieh Raeeszadeh, Borhan Shokrollahi, Abolfazl Akbari, Sima Masumi, Ali Akbar Amiri
Objectives Oxidative stress and disruption of energy metabolism in the reproductive system, especially sperm, play a significant role in diabetes-related infertility. Zataria multiflora Boissis (ZMB), a medicinal plant containing various bioactive compounds, may have efficacy in treating metabolic diseases and reproductive disorders. Therefore, the aim of this study was to investigate the effects of
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Peimisine ameliorates DSS-induced colitis by suppressing Jak–Stat activation and alleviating gut microbiota dysbiosis in mice J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-26 Yue Li, Xia Yang, Jicheng Han, Bing Bai, Yaru Li, Chao Shang, Shanzhi Li, Zhiru Xiu, Zirui Liu, Chenchen Ge, Guangze Zhu, Ningyi Jin, Jinbo Fang, Yiquan Li, Xiao Li, Yilong Zhu
Objectives Inflammatory cytokine secretion and gut microbiota dysbiosis play crucial roles in ulcerative colitis. In this research, the protective effects of peimisine on colitis mice were investigated. Methods The protective effects were evaluated by the disease activity index, colonic length, hematoxylin–eosin, and AB/PAS Staining. The protective mechanisms were analyzed by ELISA, Western-blot,
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Role of the integrin-linked kinase/TGF-β/SMAD pathway in sitagliptin-mediated cardioprotective effects in a rat model of diabetic cardiomyopathy. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-22 Anfal F Bin Dayel,Asma S Alonazi,Nawal M Alrasheed,Maha A Alamin,Wedad S Sarawi,Abeer O Alharbi,Nahla'a A Alabbad,Danah A Albuaijan,Dareen N Alassiri,Alanoud F Aljarbua,Fatimah K Almusaytir,Nouf M Alrasheed
OBJECTIVES Diabetic cardiomyopathy is a known complication of diabetes mellitus. Herein, we aimed to determine whether glycemic control mediated by sitagliptin, a dipeptidyl peptidase-4 inhibitor, can ameliorate diabetic myocardial abnormalities by modulating TGF-β signaling via the SMAD and integrin-linked kinase (ILK) pathways. METHODS Four groups of male Wistar albino rats were used, with six rats
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Deciphering the putative bioactive metabolites and the underlying mechanism of Juniperus horizontalis Moench (Creeping juniper) in the treatment of inflammation using network pharmacology and molecular docking. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-22 Alaa A El-Banna,Eman Shawky,Ismail Celik,Doaa A Ghareeb,Shaymaa A Abdulmalek,Reham S Darwish
OBJECTIVES To investigate the chemical composition of the alcoholic extract from creeping juniper leaves using HPLC-MS/MS and to elucidate its potential anti-inflammatory mechanism through network-based pharmacology analysis to collectively enable a systematic exploration of the chemical composition, mechanism of action, and therapeutic potential of the alcoholic extract from creeping juniper leaves
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Moslosooflavone protects against brain injury induced by hypobaric hypoxic via suppressing oxidative stress, neuroinflammation, energy metabolism disorder, and apoptosis. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-22 Jie Zhang,Tong Zhao,Pengpeng Zhang,Zhiqun Shi,Qingyue Da,Huiping Ma,Linlin Jing
OBJECTIVES To investigate the protect effect of moslosooflavone against brain injury induced by hypobaric hypoxia (HH) in mice. METHODS Protective effects of moslosooflavone in oxidative stress, neuroinflammation, energy metabolism disorder, and apoptosis were studied in HH-induced brain damage mice. The pathological morphology in the cortex of mice was determined by hematoxylin and eosin staining
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Isolation, phytochemistry, characterization, biological activity, and application of Morinda officinalis How oligosaccharide: a review J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-22 Jiahui Yue, Wenxin Xia, Yushu Wang, Yuanyuan Zhang, Yan Zhang, Yuxin Li, Lulu Wang, Cunbing Li, Tingting Li, Xueyan Fu
Morinda officinalis How oligosaccharide (MOO) stands as one of the principal active constituents of M. officinalis How, widely employed in traditional Chinese medicine. The methods for MOO extraction predominantly encompass hot water extraction, ethanol extraction, ultrasonic-assisted extraction, and microwave-assisted extraction. Distinct extraction techniques yield varying MOO quantities. MOO encompasses
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In vivo assessment of black seed oil single dose on prednisolone pharmacokinetics. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-18 Rana Abutaima,Yousef Al-Ebini,Ahmad Alkofahi,Anas Alshishani,Samar Thiab,Kumarappan C Alagammai,Mohammad Khalid
OBJECTIVES To investigate the effect of blackseed oil (BSO) single dose on prednisolone pharmacokinetics via p-gp inhibition. METHODS Three groups of rats (n = 5) were orally administered the vehicle, verapamil (50 mg/kg) or BSO (5 ml/kg) 15 min prior to prednisolone (5 mg/kg) administration. Blood samples were collected over 24 h and quantified. Non-compartmental analysis was employed to calculate
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Icariside I reduces breast cancer proliferation, apoptosis, invasion, and metastasis probably through inhibiting IL-6/STAT3 signaling pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-16 Manting Hou, Hui Li, Tingting He, Siwen Hui, Wenzhang Dai, Xiaorong Hou, Jing Zhao, Jia Zhao, Jincai Wen, Wen Kan, Xiaohe Xiao, Xiaoyan Zhan, Zhaofang Bai
Objectives Breast cancer is a common malignancy in women. More than 90% of breast cancer deaths are caused by metastasis. Epimedii Folium (EF) is a commonly used herb with anti-tumor benefits, but its underlying mechanisms and active components for breast cancer prevention are little understood. This study assessed the therapeutic role of Icariside I (ICS I) in Epimedium flavonoids (EF) on lung metastasis
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Pharmaceutical co-crystals: A green way to enhance drug stability and solubility for improved therapeutic efficacy J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-07 Anisha Chettri, Ankita Subba, Govind P Singh, Partha Pratim Bag
Pharmaceutical co-crystals have gained significant attention in recent years as a promising green and sustainable method for poorly soluble drugs to improve their solubility, stability, and bioavailability. In the drug development research field, it is an extremely useful technique as it does not require a large number of synthetic steps as well a minimum amount of solvent is utilized or sometimes
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Maackiain suppresses the development of cervical cancer via AMPK priming autophagy J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-07 Juan He, Lan Xiang, Tingting Zhu, Haiyan Wang, Yurong Huang, Hui Li, Chenggui Miao, Yali Zhuang, Yunxia Cao
Background Maackiain (Mac), a flavonoid analog isolated from Sophora flavescens, exhibits neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic effects. It is not clear whether Mac has a therapeutic effect on cervical cancer. Method In this work, we used RT-qPCR, western blot, immunofluorescence, and related methods to detect the therapeutic mechanism of Mac for cervical cancer. Results
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Fulvestrant alleviates cisplatin-induced acute kidney injury via repression of BNIP3-mediated apoptosis and autophagy. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-11-06 Hui-Ju Lee,Yae-Ji Kim,Kyung-Hyun Kim,Sung-Pil Cho,Geum-Lan Hong,Ju-Young Jung
Cisplatin-induced acute kidney injury (AKI) is a clinical disease characterized by a sudden loss of renal function within a few hours or days, due to cisplatin uptake. Fulvestrant is an oestrogen receptor alpha (ERα) antagonist used for endocrine therapy. However, the role of fulvestrant in cisplatin-induced AKI remains unclear. In this study, we investigated the effects of fulvestrant on the regulation
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Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-28 Fei Mu, Jiaxin Zhao, Meina Zhao, Rui Lin, Kedi Liu, Shi Zhao, Xingru Tao, Weihong Li, Qi Dai, Miaomiao Xi, Haifeng Tang, Jingwen Wang
Objectives To explore the effect of extract of Styrax (ES) on myocardial ischemic injury and its molecular mechanism, indirectly providing a theoretical basis for the development of ES. Methods In order to assess the impact of ES treatment on ischemic heart disease, both a left anterior descending ligation-induced myocardial infarction (MI) model and an ischemia/hypoxia (I/H)-induced H9c2 cell injury
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A synthetic resveratrol-curcumin hybrid derivative exhibits chemopreventive effects on colon pre-neoplastic lesions by targeting Wnt/β-catenin signaling, anti-inflammatory and antioxidant pathways. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-24 Mariane Minussi Baptistella,Raphaela Rebeca Silveira Assunção,Carolina Sales de Oliveira,Aléxia Polo Siqueira,Elda Gonçalves Dos Santos,Matheus de Freitas Silva,Ellen Tardelli Faleiros Lima,Ester Siqueira Caixeta,Rômulo Dias Novaes,Eric Batista Ferreira,Marisa Ionta,Claudio Viegas,Pollyanna Francielli de Oliveira
ABSTRACT Based on the effectiveness of resveratrol and curcumin in carcinogenesis, (E)-3-(4-hydroxy-3-methoxyphenyl)-N'-((E)-4-methoxybenzylidene) acrylohydrazide (PQM-162), curcumin-resveratrol hybrid derivative, was designed by molecular hybridization using a hydrazone functionality as a spacer moiety between pharmacophoric fragments inspired by the parent compounds. OBJECTIVES The present study
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Cardioprotection of Eucommiae Folium: the extract and pharmaceutically active compounds attenuate hyperglycemia, mitochondrial dysfunction, calcium dyshomeostasis, insulin resistance, and oxidative stress in diabetic cardiomyopathy db/db mice J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-23 Shuai-nan Zhang, Qi Liu, Xu-zhao Li, Wu-de Yang, Ying Zhou
Objectives A biolabel research based on multi-omics, informatics, molecular docking, and experimental verification was used to investigate the cardioprotective effect and pharmaceutically active compounds of Eucommiae Folium (EF). Key findings Based on the biolabel research pattern, metabonomics, proteomics, and bioinformatics indicated that EF has a therapeutic potential for a variety of heart diseases
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Hydroxyapatite-based nano-drug delivery system for nicotinamide mononucleotide (NMN): significantly enhancing NMN bioavailability and replenishing in vivo nicotinamide adenine dinucleotide (NAD+) levels J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-20 Da Zhang, Lee-Fong Yau, Long-Bo Bai, Tian-Tian Tong, Kai-Yue Cao, Tong-Meng Yan, Ling Zeng, Zhi-Hong Jiang
Objectives This study addresses the bioavailability challenges associated with oral nicotinamide mononucleotide (NMN) administration by introducing an innovative NMN formulation incorporated with hydroxyapatite (NMN–HAP). Methods The NMN–HAP was developed using a wet chemical precipitation and physical adsorption method. To assess its superiority over conventional free NMN, we examined NMN, nicotinamide
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Astaxanthin protects against pirarubicin-induced H9c2 cardiomyocytes by adjusting microRNA-494-3p-mediated MDM4/p53 signalling pathway J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-17 Peng Huang, Yibing Zhang, Fengjun Wang, Meng Qin, Jiulong Ma, Jiahua Ji, Dexian Wei, Liqun Ren
Purpose Pirarubicin (THP) is an antitumour drug widely used in clinical practice, but its cardiotoxicity limits its application. THP cardiotoxicity must be treated as soon as possible. There is an urgent need to find drugs that alleviate THP cardiotoxicity. The purpose of this study was to investigate the effects and mechanisms of Astaxanthin (AST) on THP-induced cardiomyocytes. Methods Rat cardiomyocytes
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Pharmacomagnetography assessment of the prokinetic effect on metronidazole absorption J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-13 Guilherme Augusto Soares, Gustavo Serafim Rodrigues, Lais Pereira Buranello, Ricardo Brandt de Oliveira, José Ricardo de Arruda Miranda
Objectives This study aimed to evaluate the effects of prucalopride, a prokinetic agent that acts as a potent serotonin agonist of 5-HT4 receptors, on gastric emptying and small bowel transit and assess its impact on the absorption of metronidazole. Methods Six healthy volunteers, three men and three women, aged between 20 and 27 years, with a body weight ranging from 50 to 80 kg, were enrolled in
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Using ultra-performance liquid chromatography with linear ion trap-electrostatic field orbitrap mass spectrometry, network pharmacology, and molecular docking to explore the constituent targets and action mechanisms of decoction of Angelica sinensis, Zingiberis Rhizoma Recens, and Mutton in the treatment of diarrhea-predominant irritable bowel syndrome J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-13 Zhiyong Liu, Zihong Zheng, Ting Wang, Zhiyong Liu, Zhengyun Zuo
Background Irritable bowel syndrome (IBS) is a chronic intestinal disorder characterized by abdominal discomfort, stool characteristics, and changes in bowel habits. Among them, diarrhea-type (diarrhea-predominant irritable bowel syndrome, abbreviated as IBS-D) is the most common. Because its pathogenesis is not understood, symptomatic treatment is currently used in clinical practice, and its long-term
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Photoactivation of pheophorbide-a utilizing 670 nm LEDs elicits cancer suppressive effects in androgen-independent prostate cancer cellular models J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-12 Taher Gheewala, Mohamed Ali Hussein, Gnanasekar Munirathinam
Objectives Prostate cancer (PCa) is the most commonly diagnosed cancer and the second leading cause of cancer death in men in the USA. Photodynamic therapy (PDT) is a state-of-the-art treatment that combines high selectivity with minor side effects. Pheophorbide-a (Pheo) is a natural pigment with a photosensitizer property. Our study delved into the impact of Pheo alone or Pheo-PDT combination on the
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The genus Cratoxylum: traditional use, phytochemistry and pharmacology. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-05 Nguyen Thi Huong,Nguyen Quang Hop,Ninh The Son
OBJECTIVES The genus Cratoxylum contained medicinal herbs, which are widely distributed in South-East Asia and China. Plants of this genus were consumed as a vegetable side dish, a spice, an ingredient in soup, or a substitute for tea, as well as they are traditionally appropriate for various diseases such as fever, cough, flu, diarrhoea, etc. The most aims of the current review are to highlight the
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Homoharringtonine sensitizes pancreatic cancer to erlotinib by direct targeting and miRNA-130b-3p-mediated EphB4-JAK2-STAT3 axis. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-10-05 Ammar Sarwar,Zeren Zhu,Man Zhu,Xiaoyu Tang,Qi Su,Tianfeng Yang,Wenjun Tang,Yanmin Zhang
OBJECTIVES Pancreatic cancer (PC) is a very lethal malignancy with a scarcity of treatment options. Although erlotinib- and gemcitabine-based treatments have been approved for PC, their effectiveness is limited. The present study is aimed at exploring the molecular and epigenetic mechanisms of anticancer activities of homoharringtonine (HHT) and its interaction with erlotinib to develop a potential
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Homoplantaginin attenuates high glucose-induced vascular endothelial dysfunction via inhibiting store-operated calcium entry channel and endoplasmic reticulum stress. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-09-29 Yanyan Zhou,Lei Wang,Yuchen Liu,Lili Fan,Xueying Zhang,Qingru Shi,Xulu Li,Yining Lin,Feihua Wu
OBJECTIVES The activation of store-operated calcium entry (SOCE) channel and endoplasmic reticulum stress (ERS) induced by high glucose (HG) is recognized as a major cause of vascular endothelial dysfunction. This study aims to investigate the protective effect of homoplantaginin (Hom) on HG-induced endothelial dysfunction. METHODS HG-induced vascular endothelial dysfunction model in human umbilical
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Novel peptide calcitonin gene-related peptide antagonists for migraine therapy. J. Pharm. Pharmacol. (IF 3.3) Pub Date : 2023-09-23 Patrick M Killoran,Vicky Capel,Vera D'Aloisio,Adam Schofield,Tímea Aczél,Kata Bölcskei,Zsuzsanna Helyes,Bengt von Mentzer,David A Kendall,Chris R Coxon,Gillian A Hutcheon
OBJECTIVES It has previously been shown that the peptide (34Pro,35Phe)CGRP27-37 is a potent calcitonin gene-related peptide, CGRP receptor antagonist, and in this project we aimed to improve the antagonist potency through the structural modification of truncated C-terminal CGRP peptides. METHODS Six peptide analogues were synthesized and the anti-CGRP activity confirmed using both in vitro and in vivo