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Undescribed (2–7′)-neolignans and polyoxygenated cyclohexene glycosides from the aerial parts of Piper mutabile C. DC. and their inhibitory effects on nitric oxide production Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen Huy Hoang, Ngo Anh Bang, Pham Hai Yen, Do Thi Trang, Duong Thi Dung, Nguyen Thi Cuc, Phan Thi Thanh Huong, Bui Huu Tai
A phytochemical study of the aerial parts of C. DC. revealed seven undescribed compounds [two (2–7′)-neolignans and five polyoxygenated cyclohexene glycosides] and six known propenylcatechol derivatives. The chemical structures of the isolated compounds were elucidated by extensive HR-ESI-MS and NMR analyses, as well as comparison with the literature. The absolute configurations of the (2–7′)-neolignans
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Salty treatment increased bioactive compounds accumulation during agarwood development in Aquilaria sinensis trees Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Tingting Yan, Ningnan Zhang, Zhou Hong, Yuan Chen, Gaiyun Li
To compare the bioactive compounds in agarwood induced by different methods in trees, a two dimensional thin layer chromatograph(2D-TLC) combined with effect directive analysis(EDA) was developed. Three antioxidants were found by 2D-TLC-DPPH and further identified as 2-(2-phenylethyl) chromones(PECs) with LC-MS/MS. The 3 antioxidants decreased along agarwood formation and their compositions in drilling
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Enhancement of hepatoprotective activity of limonin from citrus seeds against acetaminophen-induced liver injury by HSCCC purification and liposomal encapsulation Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Wanling Yang, Yiyao Liang, Yujie Liu, Yunan Yao, Zhiqian Yu, Baizhong Chen, Yi Cai, Minyan Wei, Guodong Zheng
Limonin is a natural tetracyclic triterpenoid compound in citrus seeds that presents hepatoprotective effects but is often discarded as agricultural waste because of its low content and low solubility. Herein, limonin with high purity (98.11%) from citrus seeds was obtained purification by high-speed counter-current chromatography (HSCCC) and recrystallization. Limonin-loaded liposomes (Lip-LM) prepared
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Cymbopogon schoenanthus (L) extract ameliorates high fat diet-induced obesity and dyslipidemia via reducing expression of lipogenic and thermogenic proteins Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Asmaa Elebishehy, Mohamed M. Ahmed, Badr Aldahmash, Mostafa Abdelgaber Mohamed, Aya A. Shetaia, Shaden A.M. Khalifa, Mabrouk Attia Abd Eldaim, Hesham R. El-Seedi, Nermeen Yosri
Globally, obesity has become one of the major health problems. This study was conducted to evaluate the anti-obesity potential of methanolic extract (CS) in rats. Fifty male Wistar rats of six to eight weeks-old, 100–120 g body weight (BW) was randomly assigned into 5 groups ( = 10): Control group was fed basal diet. CS-group was supplied with basal diet and orally given CS (200 mg/kg BW) for 12 weeks
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Type-1 diabetes: Lessons from a decade of preclinical studies on phytotherapy Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Ahmad Ghorbani, Leila Mobasheri, Mostafa Moshirian, Mohaddeseh Sadat Alavi, Omid Fakharzadeh Moghaddam, Niloofar Nikpasand, Elham Einafshar, Mahdyar Esmaeilizadeh
In recent decades, numerous herbal products have been shown to have antihyperglycemic and beta cell-regenerative effects in animal studies. However, there is no clinical evidence that those products completely cure patients with type-1 diabetes (T1D). Therefore, it seems that most of the phytochemicals do not have a significant impact on human beta cells, and the results of experimental studies conducted
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Three new indole alkaloid derivatives from Fissistigma oldhamii Levl. and their anti-inflammatory effects Fitoterapia (IF 3.4) Pub Date : 2024-03-11 De-Cai Dai, Xue-Feng Xu, Hao Yan, Yu Zhang
Three new indole alkaloid derivatives, fissindoalkas A-C (–) together with one known biogenetically related polysubstituted indole alkaloid () were isolated from the roots of (Hemsl.) Merr. The structures of compounds – were elucidated using comprehensive spectroscopic methods. The inhibitory activities of compounds – against nitric oxide (NO) production induced by lipopolysaccharide (LPS) were evaluated
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Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Yang Ke-Xin, Ma Yun-Bao, Li Tian-Ze, Wang Meng-Fei, Li Feng-Jiao, Chen Ji-Jun
Artemdubosides A-E (), the first examples of natural polyacetylenes substituted by 6’--crotonyl glucopyranoside, and artemdubosides F-G () that were two unusual polyacetylenes featuring a 6’--acetyl glucopyranoside moiety, were isolated from var. Their structures were elucidated based on the spectral data including HRESIMS, UV, IR, 1D and 2D NMR, and ECD calculations. Antihepatoma assay suggested that
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New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Xian-Zhe Fan, Jia-Qi Song, Xin-Yi Shi, Jin-Fang Zhou, Rui-Juan Yuan, Ting Liu, Xiang-Qian Kong, Ya-Si Huang, Li-Jun Zhang, Hai-Bing Liao
Three undescribed sesquiterpenes, designed as pichinenoid A-C (–), along with nine known ones (–) were isolated from the stems and leaves of . The new isolates including their absolute configurations were elucidated based on extensive spectroscopic methods, single crystal X-ray diffraction, and electronic circular dichroism (ECD) experiments, as well as comparison with literature data. Structurally
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Five new compounds from the stems of Ephedra equisetina Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Siqi Tao, Denghui Zhu, Qimei Tie, Yuanyuan Wu, Jingke Zhang, Xiaoke Zheng, Weisheng Feng
Five new compounds were identified from the stems of Bunge. Their structures were elucidated by spectroscopic methods, involving UV, IR, NMR spectrum and HRESIMS analyses. The absolute configuration of compound was proved by comparing their experimental and calculated ECD spectrum. The bioactive assay of all compounds suggested that compound , , , and may have potential anti-asthmatic activities.
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Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006 Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Jing-Wen Wang, Yi-Yi Liu, Guang-Ying Chen, Cai-Juan Zheng, Xu-Hua Nong
Nine metabolites, including three undescribed alkaloids pyripyropenes VW (–), penicioxa A (), two previously reported pyripyropene A (), oxaline (), three grisephenone-type xanthone derivatives (–), and a diphenyl ether derivative 4-chloro-7,4′-dihydroxy-5,2′-dimethoxy-2-methylformate-6′-methybenzophone (), were isolated from cultures of the mangrove-derived fungus HNNU0006. Their structures were determined
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Six unprecedented 2-(2-phenethyl)chromone dimers from agarwood of Aquilaria filaria Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Yuan Wei, Wen-Hua Dong, Wei Li, Jun Zeng, Hui-Qin Chen, Sheng-Zhuo Huang, Li Yang, Wen-Li Mei, Ya-Li Wang, Zhi-Yong Guo, Hao-Fu Dai, Hao Wang
Six new dimeric 2-(2-phenylethyl)chromones (–) were successfully isolated from the ethanol extract of agarwood of from Philippines under HPLC-MS guidance. Compounds – are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and flindersia 2-(2-phenylethyl)chromone a single ether bond, and the linkage site (C5-O-C8′′) of compound is extremely rare. A variety of spectroscopic methods
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Flavonoid glycosides from the leaves of Michelia champaca Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Meihong Liu, Yongxia Jia, Haihui Xie
L. (Magnoliaceae) was cultivated in large scale for flowers as cosmetic raw materials, whereas the value of its leaves remains to be discovered. Our chemical study on the leaves yielded four new flavonol diglycosides, champaflavosides A–D (–), together with twenty-three known flavonoid glycosides (–). Their structures were determined by spectroscopic and chemical methods. Compounds – and – were not
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Underutilized fruit lasoda (Cordia myxa L.): Review on bioactive compounds, antioxidant potentiality and applications in health bioactivities and food Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Yamini Tak, Mahesh Kumar Samota, Nirmal Kumar Meena, Gurpreet Kaur, M.C. Jain, Rajendra Kumar, Manpreet Kaur, Ryszard Amarowicz
Underutilized fruits are thought to be nutrient and antioxidant gold mines. Despite their high nutritive value, therapeutic properties, and ability to grow in adverse soil and climatic conditions, they have received little attention. However, these underutilized fruits are an important component of traditional foods, particularly in arid and semiarid regions of Rajasthan. Lasoda () contains numerous
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Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms Fitoterapia (IF 3.4) Pub Date : 2024-03-11 Md. Shimul Bhuia, Raihan Chowdhury, Iffat Ara, Md. Mamun, Razina Rouf, Muahmmad Ali Khan, Shaikh Jamal Uddin, Md. Abdul Kader Shakil, Solomon Habtemariam, Jannatul Ferdous, Daniela Calina, Javad Sharifi-Rad, Muhammad Torequl Islam
Morroniside (MOR) is an iridoid glycoside and the main active principle of the medicinal plant, Sieb. This phytochemical is associated with numerous health benefits due to its antioxidant properties. The primary objective of the present study was to assess the pharmacological effects and underlying mechanisms of MOR, utilizing published data obtained from literature databases. Data collection involved
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Anti-hemostatic, antithrombotic, and chemical profiles of a curly-leaf variety of Petroselinum crispum (Apiaceae), a food and medicinal aromatic herb Fitoterapia (IF 3.4) Pub Date : 2024-03-08 Alessandra Lyra Guedes, Livia Marques Casanova, Mariana Neubarth Coelho, Flávia Serra Frattani, Sônia Soares Costa, Russolina Benedeta Zingali
Thrombosis is currently among the major causes of morbidity and mortality in the World. New prevention and therapy alternatives have been increasingly sought in medicinal plants. In this context, we have been investigating parsley, (Mill.) Nym, an aromatic herb with two leaf varieties. We report here the , and anti-hemostatic and antithrombotic activities of a parsley curly-leaf variety. Aqueous extracts
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Protective effect of phenylpropionamides in the seed of Cannabis Sativa L. on Parkinson's disease through autophagy Fitoterapia (IF 3.4) Pub Date : 2024-03-06 Yi-kai Jiang, Meng-meng Li, Si-yi Wang, Zhi-chao Hao, Xin Meng, Hai-xue Kuang, Bing-you Yang, Yan Liu
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. As one of the major degradation pathways, autophagy plays a pivotal role in maintaining the effective turnover of proteins and damaged organelles in cells. Lewy bodies composed of α-synuclein (α-syn) abnormally aggregated in the substantia nigra are important pathological features of PD, and autophagy dysfunction
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Structurally diverse phthalides from fibrous roots of Ligusticum chuanxiong Hort. and their biological activities Fitoterapia (IF 3.4) Pub Date : 2024-03-05 Yu-Zhu Tan, Hong-Ling Yan, Yun-Yun Liu, Yong-Ming Yan, Li Wang, Ji-Xu Qiao, Jing Wu, Yin Tian, Cheng Peng
Falonolide A () and B (), two novel polyyne hybrid phthalides resulting from unprecedented carbon skeleton polymerized by -ligustilide and falcarindiol, along with six new related phthalides (–), were isolated from Hort. Their structures were elucidated by spectroscopic analysis, computer-assisted structure elucidation (CASE) analysis, DP4+ probability analysis and electronic circular dichroism (ECD)
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Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata Fitoterapia (IF 3.4) Pub Date : 2024-03-02 Yun-Yuan Tian, Lin-Lin Bi, Wen-Wen Chen, Shu-Xian Zheng, Yu Cao, Yan-Hua Xie, Hai-Feng Tang, Yun-Yang Lu, Si-Wang Wang
Two previously undescribed cholestanol saponins, parpetiosides F − G (–), and six known analogs (–) were isolated from the rhizomes of var. . Their structures were elucidated by extensive spectroscopic data analysis and chemical methods. Compound was a rare 6/6/6/5/5 fused-rings cholestanol saponin with disaccharide moiety linked at C-26 of aglycone which was hardly seen in genus . All of these compounds
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Secondary metabolites isolated from Trichoderma hamatum b-3 and their fungicidal activity Fitoterapia (IF 3.4) Pub Date : 2024-02-29 Li Huang, Meng-Dan Liu, Yi-Wen Hu, Li-Juan Chen, Yun Deng, Yu-Cheng Gu, Qiang Bian, Da-Le Guo, Guang-Zhi Wang
An undescribed trichodenone derivative (), two new diketopiperazines ( and ) along with a bisabolane analog () were isolated from b-3. The structures of the new findings were established through comprehensive analyses of spectral evidences in HRESIMS, 1D and 2D NMR, Marfey's analysis as well as comparisons of ECD. The absolute configuration of was unambiguously confirmed by NMR, ECD calculation and
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Polyacetylenes from Saposhnikovia divaricata and their anticancer activity Fitoterapia (IF 3.4) Pub Date : 2024-02-29 Yan Sun, Yan Liu, Peng Jiang, Si-Yi Wang, Juan Pan, Wei Guan, Yu-Xuan Wang, Hai-Xue Kuang, Yan-Hong Wang, Bing-You Yang
Nine polyacetylenes, including five new compounds named sadivaethynes -I (–), were isolated from the roots of . Structural elucidation of compounds – was established by extensive spectroscopic analysis, quantum chemical calculations and DP4 probability analysis. Among them, the absolute configuration of compound –, – was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity
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Synthesis, biological evaluation and docking studies of N-substituted resveratrol derivatives Fitoterapia (IF 3.4) Pub Date : 2024-02-28 Haoyu Wu, Liying Liu, Mingxiang Song, Xiaorong Yin, Mengqing Chen, Guangyao Lv, Feng Zhao, Xiaofeng Mou
A total of 19 resveratrol derivatives, including 12 imines and 7 amines, were synthesized, among which compounds , , , , , and are new compounds. The anti-inflammatory and antitumor activities of these compounds were evaluated in vitro. The results revealed that compounds , , , , and exhibited significant inhibitory effects (> 50%) on NO production at the concentration of 10 μM and their NO production
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Chemodiverse monoterpene indole alkaloids from Kopsia teoi, inhibitory potential against α-amylase, and their molecular docking studies Fitoterapia (IF 3.4) Pub Date : 2024-02-28 Muhammad Tahir Muhammad, Mehdi A. Beniddir, Lacksany Phongphane, Mohamad Hafizi Abu Bakar, Mohd Hazwan Hussin, Khalijah Awang, Marc Litaudon, Unang Supratman, Mohamad Nurul Azmi
Diabetes mellitus stands as a metabolic ailment marked by heightened blood glucose levels due to inadequate insulin secretion. The primary aims of this investigative inquiry encompassed the isolation of phytochemical components from the bark of , followed by the assessment of their α-amylase inhibition. The phytochemical composition of the culminated in the discovery of a pair of new indole alkaloids;
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Anti-breast cancer activity of the essential oil from grapefruit mint (Mentha suaveolens × piperita) Fitoterapia (IF 3.4) Pub Date : 2024-02-28 Zohreh Jahanafrooz, Mir Mohammad Hossein Mousavi, Soghra Akbarzadeh, Maedeh Hemmatzadeh, Filippo Maggi, Mohammad Reza Morshedloo
Grapefruit mint () is a hybrid, perennial, and aromatic plant widely cultivated all over the world and used in the food, cosmetics, and pharmaceutical industries mostly for its valuable essential oil. Herein, we evaluated the anticancer activity of the grapefruit mint essential oil, cultivated in Iran. For the chemical composition analysis of essential oil, GC–MS was used. MTT assay was utilized for
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Comparative analysis of chemical profiles, antioxidant, antibacterial, and anticancer effects of essential oils of two Thymus species from Montenegro Fitoterapia (IF 3.4) Pub Date : 2024-02-28 Kenan Preljević, Ivana Pašić, Milorad Vlaović, Ivana Z. Matić, Slađana Krivokapić, Nina Petrović, Tatjana Stanojković, Vladimir Živković, Svetlana Perović
The essential oils of (TVEO) and (TSEO) show different biological activities. The aim of the study was to evaluate the biological activities of TVEO and TSEO from Montenegro. The main components of TVEO were -cymene (29.52%), thymol (22.8%) and linalool (4.73%) while the main components of TSEO were -cymene (19.04%), geraniol (11,09%), linalool (9.16%), geranyl acetate (6.49%) and borneol (5.24%).
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Dauferulins A–L, daucane-type sesquiterpenes from the roots of Ferula communis: Their structures and biological activities Fitoterapia (IF 3.4) Pub Date : 2024-02-28 Yuki Yoshino, Masaki Imanishi, Licht Miyamoto, Daisuke Tsuji, Reiko Akagi, Koichiro Tsuchiya, Yoshiki Kashiwada, Naonobu Tanaka
Phytochemical study on the roots of a medicinal plant L. (Apiaceae) resulted in the isolation of 20 sesquiterpenes including 12 previously undescribed compounds, dauferulins A–L (−). The detailed spectroscopic analysis revealed – to be daucane-type sesquiterpenes with a -methoxybenzoyloxy group at C-6. The absolute configurations of – were deduced by analysis of the ECD spectra. Dauferulins A–L (–)
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The mechanistic role of curcumin on matrix metalloproteinases in osteoarthritis Fitoterapia (IF 3.4) Pub Date : 2024-02-28 Jennifer Swallow, Karin Seidler, Michelle Barrow
A systematic mechanistic review was performed to determine mechanistic evidence for curcumin on pro-inflammatory matrix metalloproteinases and Osteoarthritis to understand the underlying pathophysiology, and to evaluate available human intervention evidence to inform clinical decision making.
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Five new sesquiterpenoids isolated from Dictamnus dasycarpus Turcz Fitoterapia (IF 3.4) Pub Date : 2024-02-27 Ye Sun, Yan Liu, Si-Yi Wang, Xu Yang, Jia-Tong Wu, Juan Pan, Zhi-Chao Hao, Wei Guan, Adnan-Mohammed Algradi, Zhen-Peng Xu, Yuan-Yuan Zhou, Shao-Wa Lv, Hai-Xue Kuang, Bing-You Yang
Five new sesquiterpenoids, dictamtrinorguaianols E and F (), and dictameudesmnosides F, G, and H (), along with seven known sesquiterpenoids () were isolated from Turcz. The structures of all new compounds were characterized by spectroscopic methods, including UV, IR, HR-ESI-MS, and 1D and 2D NMR. The anti-proliferative activities of all the compounds against two human cancer cell lines (SW982 and
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New clerodane diterpenoids from Callicarpa pseudorubella and their antitumor proliferative activity Fitoterapia (IF 3.4) Pub Date : 2024-02-27 Xing Zhao, Zhaopeng Zheng, Chao Chen, Huan Wang, Hanfei Liu, Jinyu Li, Chao Sun, Huayong Lou, Weidong Pan
Six previously undescribed clerodane diterpenes, cardorubellas A-F (-), along with seven known ones (-), were isolated from the aerial parts of Their chemical structures were established by analysis of 1D and 2D NMR, HR-ESI-MS, X-ray diffraction, and electronic circular dichroism (ECD) data. Notably, cardorubella B () represented the first examples of naturally occurring succinic anhydride-containing
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Seco-nortriterpenoids from Cirsium setosum and their anti-inflammatory activity Fitoterapia (IF 3.4) Pub Date : 2024-02-27 Qing-Jiang Xu, Jia-Chen Liu, Cheng-Jin Huang, Xin Wang, Xiao-Ya Shang
Five unusual seco-nortriterpenoids, 3-hydroxy-20,21-seco-30-nortaraxastan-20,21-dioic acid (), 3-hydroxy-20,21-seco-30-nortaraxastan-20-oic-21-oate (), 3-hydroxy-20-oxo-21,22-seco-30-nortaraxastan-22-oic acid (), 3-hydroxy-19-oxo-20,21-seco-29,30-nortaraxastan-21-oic acid () and 3-hydroxy-19-oxo-20,21-seco-19-norlupan-21-oic acid () were isolated and elucidated from the anti-inflammatory activity fraction
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Phenolics and flavonoids from Polygonum posumbu and comparision of flavonoid compounds content in different tissues (leaves, stems and roots) Fitoterapia (IF 3.4) Pub Date : 2024-02-24 Premi Devi Pukhrambam, Khomdram Khedashwori Devi, Chingoileima Maibam, Roseeta Devi Mutum, Moirangthem Lakshmipriyari Devi, Sudripta Das
The growing global need for antioxidative phenolics and flavonoids for maintenance of human health resulted into search of new sustainable unexplored medicinal plants used by the traditional healers for various ailments. Many synthetic based products of phenolics and flavonoids have been used, however the demand of eco-friendly, natural herbal based products are increasing. As a result, the current
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Design, synthesis and biological evaluation of bakuchiol derivatives as multi-target agents for the treatment of Alzheimer's disease Fitoterapia (IF 3.4) Pub Date : 2024-02-19 Xiao-Qing Zhang, Yan-Nan Xiang, Tian Qin, Jing-Pei Zou, Qian-Wen Guo, Shu-Tong Han, Zhao-Yuan Zhang, Wei-Wei Liu, Gang Ding, Jing-Quan Dong, Da-Hua Shi
The concept of multi-target-directed ligands offers fresh perspectives for the creation of brand-new Alzheimer's disease medications. To explore their potential as multi-targeted anti-Alzheimer's drugs, eighteen new bakuchiol derivatives were designed, synthesized, and evaluated. The structures of the new compounds were elucidated by IR, NMR, and HRMS. Eighteen compounds were assayed for acetylcholinesterase
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Characterization, multivariate analysis and bioactivity evaluation of coumarins in the bark of Fraxinus mandshurica Fitoterapia (IF 3.4) Pub Date : 2024-02-19 Jianjin Guo, Jing Gao, Yan Guo, Lu Bai, Chi-Tang Ho, Naisheng Bai
The bark of is a traditional folk herb used to clear heat and dry dampness. To investigate the differences in coumarins content in the bark of , 24 batches of samples from four origins were collected and analyzed. Eight coumarins were obtained by traditional natural product extraction, isolation and identification techniques and quantified by high performance liquid chromatography-photodiode array
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Phytochemical analysis, antioxidant and ALR2 inhibitory activity of Sorbus torminalis (L.) fruits at different maturity stages Fitoterapia (IF 3.4) Pub Date : 2024-02-18 Karakousi Christina-Vasiliki, Beilektsidou Xanthippi, Theano Samara, Kokkalou Eugene
Thirty four compounds were identified in (L.) fruit extracts of different maturity types by means of LC-DAD-MS (ESI+) fragmentation analysis. Both immature and mature fruits were rich in flavonoid glycosides esterified with hydroxycinnamic, phenolic and dicarboxylic acids along with benzoic, phenylpropanoic and cinnamoyl quinic acid derivatives with many of them being detected for the first time in
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Abietane diterpenoids with anti-neuroinflammation activity from Rosmarinus officinalis Fitoterapia (IF 3.4) Pub Date : 2024-02-18 Tang Zhou, Ji Wang, Zhiqi Lin, Hongbo Zhu, Weiyan Hu, Rongping Zhang, Xinglong Chen
A total of 12 abietane diterpenoids were isolated and identified from in which 6 ones were undescribed compounds. Their structures were illuminated by the HRESIMS, NMR, and ECD methods and named as rosmarinusin Q-V (–). It worthy mentioned that rosmarinusin Q was a novel abietane diterpenoid with 6/6/5 skeleton whose C ring was an ,-unsaturated five-element ketone. All the compounds and four compounds
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Four unreported aporphine alkaloids with antifungal activities from Artabotrys hexapetalus Fitoterapia (IF 3.4) Pub Date : 2024-02-18 Pei Zhao, Zhiyin Yu, Jian-Ping Huang, Li Wang, Sheng-Xiong Huang, Jing Yang
In this study, the extract from showed strong antifungal activity against phytopathogenic fungi in vitro. Four unreported aporphine alkaloids, hexapetalusine A-D (–), were isolated from stems and roots of (L.f.) Bhandari, along with six known aporphine alkaloids (–). Their chemical structures were elucidated by extensive spectroscopic analysis. The absolute configurations of – were determined using
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Discovery of sesquiterpene from Youngia japonica with antitumor effect Fitoterapia (IF 3.4) Pub Date : 2024-02-18 Xian-Sheng Ye, Kuan Lin, Xiao-Qing Tao, Jin-Ting Shang, Yu-Ran Gui, Shu-Xiu Zhu, Yi-Yuan Xia, Hai-Feng Chen, Bin-Lian Sun, Wei Liu, Xi-Ji Shu
Fourteen sesquiterpenes, including one undescribed sesquiterpene lactone, were isolated from , and their structures were identified by NMR, HRESIMS, ECD and calculated ECD. Cytotoxic activities of all isolates against A549, HeLa, and 4 T1 cell lines were detected by CCK8 assay. Among them, showed obvious cytotoxic activity against A549 cells. Subsequently, the production of ROS, and apoptosis of A549
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Elucidating the therapeutic mechanism of Hengqing II decoction in Alzheimer's disease using network pharmacology and molecular docking techniques Fitoterapia (IF 3.4) Pub Date : 2024-02-15 Yajing Wang, Jiahui Jiang, Shuyu Chen, Qian Chen, Xiaojing Yan, Xiaozhong Shen
The aim of our research was to investigate the mechanism of the Hengqing II decoction in treating Alzheimer's disease (AD) through network pharmacology and experimental validation methods. Firstly, the major chemical compounds of Hengqing II decoction were characterized by ultra-high-performance liquid chromatography-high resolution mass spectrometry (UHPLC-Q-TOF-MS/MS), and the gene sets related to
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An outlook on the versatility of plant saponins: A review Fitoterapia (IF 3.4) Pub Date : 2024-02-15 Annu Jolly, Youl Hour, Young-Chul Lee
The abundance of saponin-rich plants across different ecosystems indicates their great potential as a replacement for harmful synthetic surfactants in modern commercial products. These organic saponins have remarkable biological and surface-active properties and align with sustainable and eco-friendly practices. This article examines and discusses the structure and properties of plant saponins with
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Lagerstroemia macrocarpa extract inhibits Th2-mediated STAT6 signaling pathway in human keratinocytes Fitoterapia (IF 3.4) Pub Date : 2024-02-13 Gayeon Seo, Hoyong Hyun, Minju Jeong, Yukyung Park, Jeongmin Cho, Thet Thet Mar Win, Thant Zaw Win, Jinhyup Paik, Alfan D. Arbianto, Jung-Hee Kim, Jongmin Ahn, Dongwon Kim
In this study, we examined physiological functions as a key material to develop cosmeceuticals using extracts of Wall. Ex Kurz (). Initially, the extract was treated by different concentration and antioxidant assay (DPPH and ABTS) were performed to measure free radical scavenging ability. In the cytotoxicity experiment, the extract was treated into human epidermal keratinocytes with different concentrations
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Characterization of four new cycloartane triterpenoids from Swietenia macrophylla and their angiotensin-I-converting enzyme inhibitory activity Fitoterapia (IF 3.4) Pub Date : 2024-02-12 Bongani Sicelo Dlamini, Chiy-Rong Chen, Ya-Lin Chang, Pei-Hsuan Ho, Chia-Ho Chao, Chi-I Chang
Angiotensin I-converting enzyme (ACE) inhibition is currently a common method for the treatment and control of hypertension. In this study, four new () and one known () cycloartane triterpenoids were isolated from the leaves of by chromatographic techniques and identified by their spectroscopic data and a comprehensive comparison of published data. The triterpenoids were evaluated for their ACE inhibitory
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Integrated analysis and separation of 5-lipoxygenase inhibitors from triterpenes of Poria cocos using bioaffinity ultrafiltration UPLC-Q-Exactive, molecular docking and target-based multiple complex networks Fitoterapia (IF 3.4) Pub Date : 2024-02-12 Tong Wu, Wanchao Hou, Sainan Li, Chunming Liu, Yuchi Zhang
(Schw.) Wolf () has been widely used as medical plant in East Asia with remarkable anti-Alzheimer's disease (anti-AD) activity. However, the underlying mechanisms are still confused. In this study, based on the β-Amyloid deposition hypothesis of AD, an integrated analysis was conducted to screen and separation 5-lipoxygenase (5-LOX) inhibitors from triterpenoids of and investigate the anti-AD mechanisms
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Effect of Polygonatum sibiricum saponins on gut microbiota of mice with ulcerative colitis Fitoterapia (IF 3.4) Pub Date : 2024-02-12 Rong Cao, Xinyi Fang, Ziyi Li, Sijia Li, Qinqi Guo, Yangyang Chai
is a plant with medicinal and nutritional properties. Saponins are the important biologically active components of . In this study, the specific components of saponins (PSS) were analyzed, and the regulation effect of PSS on intestinal flora in patients with ulcerative colitis (UC) was investigated by inducing male Kunming mice with dextran sulfate sodium (DSS). PSS could ameliorate the symptoms of
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Humulus lupulus aqueous extract and hydrolate as a potential ingredient for cosmetics: Chemical characterization and in vitro antimicrobial, cytotoxicity, antioxidant, and anti-inflammatory assessment Fitoterapia (IF 3.4) Pub Date : 2024-02-12 João Valente, Rita Palmeira-de-Oliveira, Liliana Guiomar, Cátia Vaz, Joana Rolo, Carlos Gaspar, Ana Sofia Oliveira, Débora Caramelo, Luiza Breitenfeld, José Carlos Gonçalves, Fernanda Delgado, José Martinez-de-Oliveira, Ana Palmeira-de-Oliveira
extracts have in their composition different molecules, such as polyphenols, α-acids, β-acids, and hydrocarbons, which contribute to the plant's medicinal properties. These molecules are associated with antimicrobial, antioxidant, and anti-inflammatory activities. This work focuses on the evaluation of biological activities, with the aim of evaluating its potential for inclusion in cosmetic formulations
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Antiulcer activity of Mauritia flexuosa L.f. (Arecaceae) pulp oil: An edible Amazonian species with functional properties Fitoterapia (IF 3.4) Pub Date : 2024-02-12 Maria de Fátima Rodrigues, José Wellinton da Silva, Jucielma Silva de Lima, Bárbara de Azevedo Ramos, Silvania Tavares Paz, Diego Lomonaco, Davila Zampieri, Rafael Matos Ximenes
, known as buriti in Brazil, is a widespread palm tree in Amazonia. It has many ethnobotanical uses, including food, oil, and medicine. The oil obtained from buriti's fruit pulp has high levels of monounsaturated fatty acids, carotenoids, and tocopherols, and is used in the food, cosmetic, and pharmaceutical industries for its antioxidant properties. Many biological activities have been reported for
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Enhancing lathyrane structural diversity and MDR activity by combinatorial modification of lathyrane nucleus and ester side chain: A case study of Euphorbia Factor L1 and Euphorbia Factor L3 Fitoterapia (IF 3.4) Pub Date : 2024-02-06 Zilong Zhan, Xin Liu, Zhihong Cheng
The chemical transformation of lathyrane nucleus through reduction and oxidation reactions using Euphorbia Factor L1 (EFL1) and Euphorbia Factor L1 (EFL3) as examples were investigated, along with a co-modification strategy of lathyrane nucleus and its side ester chain. A total of 38 lathyrane derivatives (–) including 34 new compounds were obtained, which greatly enriched the structural diversity
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Two rearranged acylphloroglucinols with moderate neuroprotective effects from Hypericum ascyron Linn. Fitoterapia (IF 3.4) Pub Date : 2024-02-05 Shuo Wang, Yuyu Shao, Lingran Tian, Lingyu Li, Shuqi Wang, Xiaoning Wang, Tao Shen, Dongmei Ren
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Dimeric ent-kauranoids isolated from Isodon japonica var. Glaucocalyx and their anti-inflammatory activities Fitoterapia (IF 3.4) Pub Date : 2024-01-29 Ge Wang, Ao-Xue Ding, Guo-Qing Qin, Tong Chen, Xiang-Gang Hu, Liu Zheng, Gao-Xiang Du, Wenqiong Wang, Lijiang Xuan
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Phytochemical analysis and antihyperglycemic activity of Castilleja arvensis Fitoterapia (IF 3.4) Pub Date : 2024-01-29 Mónica Aideé Díaz-Román, Juan José Acevedo-Fernández, Gabriela Ávila-Villarreal, Elizabeth Negrete-León, A. Berenice Aguilar-Guadarrama
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New indolequinazoline alkaloids from the fruits of Tetradium ruticarpum Fitoterapia (IF 3.4) Pub Date : 2024-01-30 Mu Li, Xin-Lin Chen, Zhan-Peng Yu, Ya-Lin Li, Li-Hong Hong, Yu-Xing Cai, Ling-Yi Kong, Jian-Guang Luo
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Multi-level chemical characterization and anti-inflammatory activity evaluation of the polysaccharides from Prunella vulgaris Fitoterapia (IF 3.4) Pub Date : 2024-01-29 He Sun, Jia Lou, Bo-Xue Chen, Jia-Qi Huang, Qi-Long Wang, Shao-Fei Song, Zi-Yue Jia, Rong Miao, Shi-Yu Wang, Xue Li, Wen-Zhi Yang
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LC-MS/MS analysis of Shenghui decoction component and its effect on learning and memory and neuroprotection in sleep deprivation model mice Fitoterapia (IF 3.4) Pub Date : 2024-02-02 Chun Wen, Zi-Heng Li, Li Cheng, Jun-Zuo Zheng, Ping Wang, Linlin Chen, Qiu-Yun You, Li Ding
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A new integrated strategy for high purity pinolenic acid production from Pinus koraiensis Sieb. et Zucc seed oil and evaluation of its hypolipidemic activity in vivo Fitoterapia (IF 3.4) Pub Date : 2024-01-29 Linan Sun, Maoyu Zhang, Xiaodan Wu, Sansan Bao, Liang Yu, Ying Wang, Yujie Fu
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Research on the antipruritic active ingredients of Mikania micrantha Fitoterapia (IF 3.4) Pub Date : 2024-01-28 Qianqian Cheng, Bin Lyu, Jingweng Hu, Zhiqiang Zhang, Yusheng Huang, Zhenhua Wang
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Five new secondary metabolites from Aster tataricus Fitoterapia (IF 3.4) Pub Date : 2024-02-01 Jian-Li Li, Chao Chen, Min-Jie Ma, Pei Li, Si-Qi Yang, Rui Guo, Chun-Lei Zhang, Yan-Gang Cheng
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New steroidal saponins from the aerial parts of Paris polyphylla var. yunnanensis and their effects on blood coagulation Fitoterapia (IF 3.4) Pub Date : 2024-01-30 Wei Nie, Hong-yan Zhang, Yan-xia Ma, Jin-Fu Wan, Li-Ping Feng, Tao Cui, Qian Li
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Chemical characterization of three different extracts obtained from Chelidonium majus L. (Greater celandine) with insights into their in vitro, in silico and network pharmacological properties Fitoterapia (IF 3.4) Pub Date : 2024-01-30 Milena Terzic, Shaimaa Fayez, Nouran M. Fahmy, Omayma A. Eldahshan, Abdullahi Ibrahim Uba, Sathish Kumar M. Ponniya, Selami Selvi, , Ismail Koyuncu, Özgür Yüksekdağ, Gokhan Zengin
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Diverse diterpenoids and a triterpenoid from Euphorbia spinidens Bornm. ex Prokh Fitoterapia (IF 3.4) Pub Date : 2024-01-29 Abolfazl Shakeri, Mohammad Reza Mirahmadi, Olaf Kunert, Yu-Chi Tsai, Anita Barta, Judit Hohmann, Javad Asili
Four previously unreported diterpenoids including three -atisanes () and one -abietane (), along with one known linear triterpenoid () and five known diterpenoids including four myrsinanes (), and one abietane () have been isolated from the roots of Bornm. ex Prokh. The structures were determined on the basis of extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR and comparison of the
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Citrisorbicillinol, an undescribed hybrid sorbicillinoid with osteogenic activity from Penicillium citrinum ZY-2 Fitoterapia (IF 3.4) Pub Date : 2024-01-28 Ying Zhang, Jing Zhang, Qi Du, Xue Ming Wu, Yong Chen, Ren Xiang Tan
Citrisorbicillinol (), along with six other known compounds (–), was isolated from an endphyte ZY-2 of L. Citrisorbicillinol () was characterized as a skeletally unprecedented hybrid sorbicillinoid, and its unique framework is likely formed by intermolecular [4 + 2] cycloaddition between intermediates derived from citrinin and sorbicillinoid biosynthetic gene clusters. Compounds and demonstrated to