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Toxicity of commercial and pure forms of three nonsteroidal anti-inflammatory drugs in Xenopus laevis embryos before and after ozonation Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-11 Fatma Bilge Emre, Duygu Özhan Turhan, Abbas Güngördü
In this study, the toxic and teratogenic effects of three commercial drugs and their active ingredients on Xenopus laevis embryos before and after ozonation were evaluated using the Frog Embryos Te...
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Both acute glyphosate and the aminomethylphosphonic acid intoxication decreased the acetylcholinesterase activity in rat hippocampus, prefrontal cortex and gastrocnemius muscle Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-11 Jesús Chávez-Reyes, Carlos H. López-Lariz, Bruno A. Marichal-Cancino
It has been reported that glyphosate, one of the most common herbicides used in agriculture, impairs locomotion and cognition. Glyphosate has a variable half-life in soil up to biotic and/or abioti...
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A toxicological review of alkaloids Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-11 Nannan Yang, Jiafu Guo, Jian Zhang, Song Gao, Qiwen Xiang, Jiayu Wen, Yan Huang, Chaolong Rao, Yan Chen
Alkaloids are naturally occurring compounds with complex structures found in natural plants. To further improve the understanding of plant alkaloids, this review focuses on the classification, toxi...
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Beneficial effects of adipose-derived stromal vascular fraction on testicular injury caused by busulfan Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-11 E. Rumeysa Hekimoglu, Mukaddes Esrefoglu, Fatma Bedia Karakaya Cimen, Birsen Elibol, Huri Dedeakayogullari, Özge Pasin
The use of stem cells can attenuate testicular injury and promote sperm production. The adipose-derived stromal vascular fraction (SVF) has become an attractive cell source for cell-based therapies...
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Sweet basil (Ocimum basilicum) leaf and seed extracts alleviate neuronal dysfunction in aluminum chloride-induced neurotoxicity in Drosophila melanogaster Meigen model Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-04 Olubukola H. Oyeniran, Famusiwa D. Courage, Adedayo O. Ademiluyi, Ganiyu Oboh
Ocimum basilicum is an important medicinal plant and culinary herb generally known as sweet basil (SB). These plants are effective radical scavengers, that have been employed in treatment of nervou...
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Fumaric acid protects rats from ciprofloxacin-provoked depression through modulating TLR4, Nrf-2, and p190-rho GTP Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-04 Marwa M. Khalaf, Heba M. Mahmoud, Mohamed A. Kandeil, Hend A. Mahmoud, Abeer A. Salama
Depression is a persistent illness affecting health, behavior, and performance in life. Worldwide morbidity and mortality are caused by depression. The current study intended to explore fumaric aci...
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Identification, trace level quantification, and in silico assessment of potential genotoxic impurity in Famotidine Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-01 Faiz Hussain Sayyed, Nitin Rathod, Vipin Kumar Mishra, Vighnesh Nalawade, Bappaditya Roy
Potential genotoxic impurities in medications are an increasing concern in the pharmaceutical industry and regulatory bodies because of the risk of human carcinogenesis. To prevent the emergence of...
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Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and Caenorhabditis elegans by regulating redox homeostasis Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-03-01 Acharya Balkrishna, Vivek Gohel, Nishit Pathak, Kunal Bhattacharya, Rishabh Dev, Anurag Varshney
Treatment with cationic amphiphilic drugs like Amiodarone leads to development of phospholipidosis, a type of lysosomal storage disorder characterized by excessive deposition of phospholipids. Such...
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Effects of low-dose ionizing radiation on the molecular pathways linking neurogenesis and autism spectrum disorders in zebrafish embryos Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-21 Burcu Yeliz Kollayan, Derya Cansiz, Merih Beler, Ismail Unal, Ebru Emekli-Alturfan, Sebnem Ercalik Yalcinkaya
Prenatal exposure to environmental factors may play an important role in the aetiopathogenesis of autism spectrum disorder (ASD). We aim to investigate the potential effects of low-dose x-rays from...
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Evaluation of Global Dystonia Rating Scale as a predictor of unfavorable outcomes among acute antipsychotics poisoned patients Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-13 Asmaa Fady Sharif, Zahraa Khalifa Sobh, Sanaa Abd El-Fatah Abdo, Osama M. Alahmadi, Hatem A. Alharbi, Mohannad Saif Awaji, Faris A. Alabdullatif, Abdullah M. Baghlaf, Ahmad F. Alanazi, Manar Maher Fayed
Worldwide, acute antipsychotic poisoning results in high morbidities and mortalities. Though extrapyramidal syndromes are commonly associated, the extent of extrapyramidal syndromes in relation to ...
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Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-13 Ebru Şancı, Çinel Köksal Karayıldırım, Melih Dağdeviren, Gürkan Yiğittürk, Aylin Buhur, Oytun Erbaş, Altuğ Yavaşoğlu, Nefise Ülkü Karabay Yavaşoğlu
Streptozotocin (STZ) is used as a diabetes-inducing agent in experimental animal studies. However, it is known that STZ-induced diabetic animals show significant increases in oxidative stress param...
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Preparation, characterization, and toxicity evaluation of microemulsion formulation containing prunetin for potential oral applications Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-08 Çinel Köksal Karayıldırım, Neslihan Üstündağ Okur, Mehmet Evren Okur, Emre Şefik Caglar, Ayşe Nalbantsoy, Karar Ali Mohammed Hasan Alsakını, Nefise Ülkü Karabay Yavasoglu
Phytochemicals as therapeutic alternatives can have a fundamental impact on the various stages of inflammation and its resolution. Prunetin is a naturally occurring isoflavone and has been claimed ...
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Hepatoprotective effect of methanol fruit extract of Punica granatum L in highly active antiretroviral therapy-induced toxicity in Wistar rats Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-08 Eliah Kwizera, Eddie M. Wampande, Charles D. Kato, Pastori Mujinya, Allan Wandera, Fred Bwambale, Jackie Rachael Mpumbya, Robert Siida, Kenneth Ssekatawa
Prolonged use of Highly Active Antiretroviral Therapy (HAART) has been linked to toxicity, particularly hepatotoxicity. There are few effective drugs for HAART patients that promote hepatic cell re...
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Preclinical toxicological assessment of polydatin in zebrafish model Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-04 Lucia Emanueli Schimith, Vitória Machado da Silva, Dennis Guilherme da Costa-Silva, Linda Karolynne Seregni Monteiro, Ana Luiza Muccillo-Baisch, Corinne André-Miral, Mariana Appel Hort
Polydatin (3,4’,5-trihydroxystilbene-3-β-D-glucoside, piceid), a natural stilbenoid found in different plant sources, has gained increasing attention for its potential health benefits. However, pri...
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Toward a greener multifunctional pharmaceutical excipient: in vivo safety evaluation of nanofibrillated cellulose from tobacco stalk Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-07 Keth Ribeiro Garcia, Rafaella Câmara Rocha Menezes, Venina dos Santos, Letícia Scherer Koester, Eliane Dallegrave
Tobacco stalk is a cellulose-rich material and a sustainable alternative to be applied as a plant-based nanofibrillated cellulose (NFC) source. NFC use has garnered attention in the development of ...
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Testing the detoxification power of black cumin oil (Nigella sativa) over cypermethrin insecticide effects in rainbow trout (Oncorhynchus mykiss) at multiple scales Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-07 Veysel Karani Gültekin, Muhammed Atamanalp, Arzu Ucar, Gonca Alak, Veysel Parlak
This study investigated the curative effect of black cumin oil (Nigella sativa, NS), which is a phytotherapeutic agent against to cypermethrin (CYP), which is known to have adverse effects on rainb...
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Pre-clinical and cellular safety assessment of oral administered DHA rich microalgae oil from Schizochytrium sp. (Strain ATCC-20889): acute, sub-chronic and genotoxicity Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-02-04 Shubham Thakur, Harmanpreet Singh, Sunil Sharma, Manjot Kaur, Amrinder Singh, Arvinder Kaur, Subheet Kumar Jain
The lack of toxicity data for DHA-rich oil from Schizochytrium sp. (Strain ATCC-20889) leads to its exclusion from the Qualified Presumption of Safety list. Therefore, present study addresses toxic...
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Safety assessment of Wuzhuyu decoction extract: acute and subacute oral toxicity studies in rats Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-30 Zhiyong Xu, Yongtian Yuan, Yueming Yuan, Li Ru, Zheng Yuan, Qin Xu, Xiaobo Li
Wuzhuyu decoction (WZYD) is a well-known classic traditional Chinese medicine prescription and has been widely used to treat headache, nausea, vomiting, insomnia, etc. However, little published inf...
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Safety evaluation of Gamisoyo-san: genotoxicity, acute toxicity, and influence on drug-metabolizing enzymes Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-30 Seong Eun Jin, Mee-Young Lee, Hyekyung Ha, Hyeun-Kyoo Shin, Chang-Seob Seo
Gamisoyo-san is an herbal formula widely used to treat psychological issues, menopausal symptoms, and dysmenorrhea. However, there is insufficient information on its safety profile. This study aime...
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Determination of micronuclei frequency in Danio rerio for assessing genotoxicity induced by propineb Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-15 Pinar Goc Rasgele, Fatma Demir, Serife Gulsun Kirankaya
The aim of this study was to investigate the genotoxic effect of Propineb fungicide at different concentrations (0.167, 0.335 and 0.670 mg L−1) and different treatment times (24, 48, 72 and 96 h) o...
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Unraveling the neuroprotective mechanisms of naltrexone against aluminum-induced neurotoxicity Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-14 Sonia Sanajou, Anil Yirün, Deniz Arca Çakır, Göksun Demirel, Gönül Şahin, Pinar Erkekoğlu, Terken Baydar
Aluminum (Al) is a known neurotoxic trace element linked to Alzheimer’s disease (AD). Naltrexone, an opioid antagonist, has shown promising effects in reducing neuroinflammation at lower doses than...
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Correction Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-12
Published in Drug and Chemical Toxicology (Vol. 47, No. 1, 2024)
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Prognostic value of systemic immune-inflammation index and monocyte-to-HDL-cholesterol ratio in early cardio-cerebral complications in elderly patients with acute severe carbon monoxide poisoning Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-12 Jia Li, Hong-na Qi, Ping Gong, Yuan-yuan Wang, Qing-mian Xiao, Pu Wang, Wei-zhan Wang
To investigate how effectively systemic immune-inflammation index (SII) and Monocyte-to-HDL-cholesterol ratio (MHR) predict the development of early cardio-cerebral complications in elderly patient...
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Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-08 Debiao Pan, Jun Wang, Hailin Ye, Yong Qin, Shengqian Xu, Guanxiong Ye, Hejuan Shen
Tauroursodeoxycholic acid (TUDCA) can activate farnesoid X receptor (FXR) to involve in the formation of gallstones. Here, this study aimed to probe the potential mechanism of TUDCA-FXR network in ...
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Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway Drug Chem. Toxicol. (IF 2.6) Pub Date : 2024-01-03 Shenglan Shang, Weiliang Li, Fan Zhou, Yan Zhao, Mengchen Yu, Ling Tong, Huawen Xin, Airong Yu
Cyclosporine-A (CsA) is currently used to treat immune rejection after organ transplantation as a commonly used immunosuppressant. Liver injury is one of the most common adverse effects of CsA, who...
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Ferroptosis: action and mechanism of chemical/drug-induced liver injury Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-12-26 Li Zeng, Xueli Jin, Qing-Ao Xiao, Wei Jiang, Shanshan Han, Jin Chao, Ding Zhang, Xuan Xia, Decheng Wang
Drug-induced liver injury (DILI) is characterized by hepatocyte injury, cholestasis injury, and mixed injury. The liver transplantation is required for serious clinical outcomes such as acute liver...
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Single and repeat-dose toxicity and local tolerance assessment of newly developed oil emulsion adjuvant formulations for veterinary purposes Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-12-13 Karrar Ali Mohammed Hasan Alsakini, Ebru Sanci, Aylin Buhur, Altuğ Yavasoglu, N. Ülkü Karabay Yavasoglu, Ayşe Nalbantsoy
Adjuvants are components of vaccines that boost the intensity, duration, and breadth of the immune response. Insight into the mechanisms responsible for the immunotoxicity of both local and systemi...
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Effects of acetaminophen exposure on behavior and erythrocyte nuclear morphology of juvenile Oreochromis niloticus Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-12-12 Dissanayakage Dilshan Sampath Dissanayaka, S. H. N. P. Gunawickrama, Thakshila Nadeeshani Dharmapriya, K. B. S. Gunawickrama
The occurrence of pharmaceuticals in the environment can have undesirable effects on nontarget animals, including fish. The present experiment assessed the effects of subchronic exposure to waterbo...
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Some relevant mitigating agents of chronic aflatoxin exposure: a treatise Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-12-07 Mohammad Nazari, Reza Heidari, Zahra Hami, Mahdi Shiri, Ehsan Nassireslami, Mohsen Chamanara
Aflatoxins, a group of toxic secondary metabolites produced by Aspergillus species, pose significant threats to human health due to their potent carcinogenic, mutagenic, and immunosuppressive prope...
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Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-12-04 Guangtao Yang, Wei Zhou, Minhong Zhang, Xiaohuan Zhong, Haili Qiu, Yingping Xiang, Zhimin Zhang, Peimao Li, Dianpeng Wang
In this study, we established SH-SY5Y human neuroblastoma cells as an in vitro model to investigate whether oxidative stress and the nuclear erythroid-2 related factor 2 (Nrf2) signaling pathway ar...
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Insight into the mechanism and toxicology of nitrofurantoin: a metabolomics approach Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-11-26 Olakunle Sanni, David D. N’Da, Gisella Terre’Blanche
Safety and effectiveness are the two ends of the balance in drug development that needs to be evaluated. The biotransformation of drugs within a living organism could potentiate biochemical insults...
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Ginsenoside Rg3 improves microcystin-induced cardiotoxicity through the miR-128-3p/MDM4 axis Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-11-21 Xiaoming Zhou, Xiaoyan Xia
Microcystin (MC) is the byproduct of cyanobacteria metabolism that is associated with oxidative stress and heart damage. This study aimed to investigate the effect of ginsenoside Rg3 on MC-induced ...
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Omeprazole induces profibrotic gene expression in rat kidney: implication of TGF-β/Smad signaling pathway Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-11-20 Albatoul Allam, Azza A. Ali, Naira A. Abdel Baky, Amany Balah
Proton pump inhibitors (PPIs) are one of the most commonly prescribed medications. However, PPI usage is linked to a higher risk of both acute and chronic renal damage by mechanisms not entirely kn...
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Outcome prediction of methadone poisoning in the United States: implications of machine learning in the National Poison Data System (NPDS) Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-11-09 Omid Mehrpour, Farhad Saeedi, Varun Vohra, Christopher Hoyte
Methadone is an opioid receptor agonist with a high potential for abuse. The current study aimed to compare different machine learning models to predict the outcomes following methadone poisoning. ...
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Topiramate’s effects on normal and fatty liver Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-11-02 Sevtap Kılınç, Pelin Şahin, Zeynep Yığman, Ayşe Meltem Sevgili
Topiramate (TPM), a carbonic anhydrase (CA) inhibitor, is known for its anti-obesity effect. Even though, nonalcoholic fatty liver disease (NAFLD) is present in 80% of obese patients, TPM’s effects...
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A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-10-05 Alican Kaya, Aslı F. Ceylan, Mustafa Kavutcu, Abel Santamaria, Marta Šoltésová Prnová, Milan Stefek, Çimen Karasu
Inhibiting aldose reductase (ALR2, AR) as well as maintaining a concomitant antioxidant (AO) activity via dual-acting agents may be a rational approach to prevent cellular glucotoxicity and at leas...
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Cytogenetic damage by vanadium(IV) and vanadium(III) on the bone marrow of mice Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-10-05 Lucila Álvarez-Barrera, Juan José Rodríguez-Mercado, Rodrigo Aníbal Mateos-Nava, Adolfo Acosta-San Juan, Mario Agustín Altamirano-Lozano
Vanadium is a strategic metal that has many important industrial applications and is generated by the use of burning fossil fuels, which inevitably leads to their release into the environment, main...
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Assessment of redox homeostasis via genotoxicity, cytotoxicity, apoptosis and NRF-2 in colorectal cancer cell lines after treatment with Ganoderma lucidum extract Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-09-13 Yasin Tülüce, Ahmet Yasin Keleş, Sedat Köstekci
Abstract This study aimed to investigate the cytotoxic and apoptotic effects of Ganoderma lucidum, Pleurotus ostreatus, Pleurotus eryngii, and Inonotus hispidus fungal extracts on HT-29 and HCT-116 colorectal cancer cell lines and to search the DNA damage and oxidative stress caused by these extracts. Accordingly, mushroom extracts were applied to colorectal cancer cell lines in vitro, and the IC50
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Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafish Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-08-30 Namita Muduli, Sai Aparna, Manorama Patri, Khirod Kumar Sahoo
Saffron is a well-known expensive spice, which has many pharmacological properties against a variety of ailments. Saffron stigma and leaf contain apocarotenoids and bioactive phytochemicals having ...
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Correction Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-08-24
Published in Drug and Chemical Toxicology (Vol. 47, No. 1, 2024)
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Effects of sodium hydrosulfide (NaHS) on cisplatin-induced hepatic and cardiac toxicity Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-08-08 Esrafil Mansouri, Zeinab Shafiei Seifabadi, Nastaran Azarbarz, Maasoumeh Zare Moaiedi
In recent years, the cardiotoxicity and hepatotoxicity induced by chemotherapeutic drugs such as cisplatin (CP) have become significant issues. The current research looks into the effects of sodium...
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Study on the acute toxicity of sodium taurocholate via zebrafish mortality, behavioral response, and NMR-metabolomics analysis Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-08-07 Isah Abdulazeez, Intan Safinar Ismail, Siti Munirah Mohd Faudzi, Annie Christianus, Seok-Giok Chong
Sodium taurocholate (NaT) is a hydrophobic bile salt that exhibits varying toxicity and antimicrobial activity. The accumulation of BSs during their entero-hepatic cycle causes cytotoxicity in the ...
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Anti-ischemic drug trimetazidine blocks mercury nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-dependent apoptosis in rats Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-08-02 Azza Sedky, Ademola C. Famurewa
Abstract Trimetazidine (TMZ) is a promising emerging therapeutic piperazine derivative for renal pathologies. However, the nephroprotective mechanism of TMZ against heavy metal-induced toxicity is unknown. This study, therefore, aimed to explore whether TMZ could mitigate mercury-induced nephrotoxicity in rats. Rats were injected TMZ (3 mg/kg bw) and/or mercury chloride (HgCl2) (4 mg/kg bw) for 4 days
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Formulation and evaluation of solid lipid nanoparticles loaded with papaya seed chloroform extract for long-term antifertility effects on the male rat, Bandicota bengalensis Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-28 Ruchika Thukral, Payal Arora, Sunidhi Sharma, Diptiman Choudhury, Neena Singla
Abstract The study is the first to formulate and investigate potential of papaya seed chloroform extract based solid lipid nanoparticles (PSCEN) as antifertility agents on male Bandicota bengalensis. The prepared nanoparticles were spherical of size 300–600 nm. The release kinetics showed a controlled release of the drug with major release over 48 h. To assess the antifertility effects of PSCEN, adult
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Long-term toxicity of fluoroquinolones: a comprehensive review Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-28 Narmin Hama Amin Hussen, Shnyar Hamid Qadir, Heshu Sulaiman Rahman, Yusra Yassin Hamalaw, Parsan Siyamand Shekh Kareem, Botan Aziz Hamza
Abstract Fluoroquinolones (FQs) are highly potent bactericidal antibiotics with broad-spectrum activity against Gram-negative/positive bacteria. The Food and Drug Administration (FDA) anticipated the presence of a long-lasting incapacity of Fluoroquinolone Associated Toxicity (FQAT), which is not officially documented yet. This review aimed to précis the existing information on FQA long-term toxicity
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Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-28 Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Roham Foroumadi, Mahdi Gholami, Shokoufeh Hassani, Soheyl Mirzababaei, Hamed Haghi-Aminjan, Mona Navaei-Nigjeh, Mahban Rahimifard, Mohammad Abdollahi
Abstract Chlorpyrifos (CPF) is a widely used pesticide that can impair body organs. Nonetheless, metformin is known for its protective role against dysfunction at cellular and molecular levels led by inflammatory and oxidative stress. This study aimed to investigate the modulatory impacts of metformin on CPF-induced heart and lung damage. Following the treatment of Wistar rats with different combinations
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Toxicity of ciprofloxacin and ofloxacin to Moina macrocopa and investigation of p-value adjustments for (eco)toxicological studies Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-25 Tan-Duc Nguyen, Tomoaki Itayama, Norio Iwami, Kazuya Shimizu, Thanh-Son Dao, Thanh Luu Pham, Vinh Quang Tran, Hideaki Maseda
Abstract Ciprofloxacin (CFX) and ofloxacin (OFX) are commonly found as residual contaminants in aquatic environments, posing potential risks to various species. To ensure the safety of aquatic wildlife, it is essential to determine the toxicity of these antibiotics and establish appropriate concentration limits. Additionally, in (eco)toxicological studies, addressing the issue of multiple hypothesis
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Atrazine residue in waters of Ijebu-North local government, Nigeria: implications on human health, hematological, and biochemical parameters Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-16 Rasheed Yemi Oladunjoye, Folarin Ojo Owagboriaye, Oyebamiji Oladeni Fafioye, Oladunni Nimota Adekunle, Mistura Temitope Adeleke, Sulaimon Adebisi Aina, Titilola Fausat Salisu, Raheem Adekunle Asiru, Olusegun Adebayo Lawal, Titilayo Oyeronke Adesetan
Abstract Knowledge and implications of atrazine in waters from rural areas in Nigeria remain diminutive. Meanwhile, recent findings have shown presence of atrazine residue in water bodies. Atrazine level in six communities (Mamu, Oru, Ilaporu, Awa, Ijebu Igbo, and Ago-Iwoye) of Ijebu North local government, Ogun State, Nigeria using 69 hand-dug wells (HDWs), 40 boreholes (BHs) and four streams are
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Computational modeling (in silico) methods combined with ecotoxicological experiments (in vivo) to predict the environmental risks of an antihistamine drug (loratadine) Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-11 Vinicius Roveri, Luciana Lopes Guimarães, Alberto Teodorico Correia
Abstract This study employed computational modeling (in silico) methods, combined with ecotoxicological experiments (in vivo) to predict the persistence/biodegradability, bioaccumulation, mobility, and ecological risks of an antihistamine drug (Loratadine: LOR) in the aquatic compartment. To achieve these goals, four endpoints of the LOR were obtained from different open-source computational tools
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Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-10 Kürşat Kaya, Yasemin Şahin, Hasan Hüseyin Demirel, Osman Çiftçi
Abstract Favipiravir is a nucleoside analogue antiviral drug and inhibits the replication of many RNA viruses, especially influenza viruses. Favipiravir has also been used to treat patients with mild to moderate COVID-19 disease. However, various side effects, including neurological side effects, have been reported related to the use of favipiravir. Therefore, in this study, we aimed to investigate
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Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-07-04 Abiola S. Tijani, Tolessa M. Daba, Ime A. Ubong, Onaadepo Olufunke, Elemi J. Ani, Ebenezer O. Farombi
Abstract This study investigated the capability of a co-delivery system of thymol (THY) and sulfoxaflor that can serve to minimize the development of epididymal and testicular injury arise from SFX exposures alone. Forty-eight adult male rats were orally treated by gavage for 28 consecutive days. The rats were divided into six groups comprising control, THY alone (30 mg/kg), low SFX alone (79.4 mg/kg)
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Comparative evaluation of natural and artificial sweeteners from DNA damage, oxidative stress, apoptosis, to development using Drosophila melanogaster Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-30 Ghada Tagorti, Burçin Yalçın, Merve Güneş, Ayşen Yağmur Burgazlı, Bülent Kaya
Abstract The overconsumption of added sugars makes people vulnerable to a myriad of diseases. Several biochemical and developmental assays were performed in the current study to assess the effect of fructose on Drosophila melanogaster and to find substitutes for fructose by comparing it to well-known sweeteners. Drosophila was exposed separately to the same ratio of sugar 9.21% (w/v) of several types
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Hesperidin via maintenance of mitochondrial function and antioxidant activity protects lithium toxicity in rat heart isolated mitochondria Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-27 Mohammad Shabani, Zhaleh Jamali, Deniz Bayrami, Ahmad Salimi
Abstract Lithium is commonly used in the treatment of bipolar disorders (BD) and consumer electronics. It has been reported that lithium exposure is associated with mitochondrial dysfunction and oxidative stress in isolated cardiac mitochondria. Mitochondrial protection has a key role in myocardial tissue homeostasis, cardiomyocyte survival and inhibition of cardiotoxicity. Hesperidin as a flavanone
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Effect of Salvia officinalis aqueous infusion on copper sulfate-induced inflammatory response and oxidative stress imbalance in mice liver and kidney Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-26 Houcine Dab, Said Ben Hamed, Amel Jery, Amel Chehidi, Lazhar Zourgui
Abstract Extracts of Salvia officinalis (S. officinalis) have been described to have many therapeutic properties. However, the effect of S. officinalis on copper sulfate toxicity has not been previously reported. The aim of this study was to investigate the toxicity of copper sulfate and the potential beneficial effects of S. officinalis aqueous infusion on proinflammatory response and antioxidant
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The effect of glycine on oxidative stress, inflammation and renin-angiotensin system in kidneys and aorta of cyclosporine-administered rats Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-20 Rivaze Kalaycı, İlknur Bingül, Merva Soluk-Tekkeşin, Vakur Olgaç, Seldağ Bekpınar, Müjdat Uysal
Abstract Cyclosporine A (CsA) is an immunosuppressive drug, used in organ transplantations. Oxidative stress, inflammation and renin-angiotensin system (RAS) activation play an important role in CsA-toxicity. Glycine (Gly) has antioxidant and anti-inflammatory effects. In this study, Gly was investigated for its protective role against CsA-induced toxicity. CsA (20 mg/kg/day; subcutaneously) was administered
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In vitro assessment of the antioxidative, toxicological and antimicrobial properties of battery of parabens Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-19 Stela Katavic, Ilma Cehic, Nejla Zukic, Merjem Mirvic, Muamer Dizdar, Ana Gutalj, Belmina Saric Medic, Anesa Jerković-Mujkić, Irma Mahmutović-Dizdarević, Aner Mesic
Abstract The aim of this study was to evaluate antioxidative features using 2,2-diphenyl-1-pycrylhydrazyl free radical (DPPH•) scavenging method, bovine serum albumin (BSA)-binding properties with usage of spectrofluorimetric method, proliferative and cyto/genotoxic status by use of chromosome aberration test, and antimicrobial potential using broth microdilution method, followed by resazurin assay
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Assessment of imidacloprid induced genotoxicity in Pethia conchonius (Rosy barb), a common freshwater fish of India Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-16 Debojit Dutta, Arpita Ray, Bappaditya Ghosh, Min Bahadur
Imidacloprid is one of the highly efficient, globally used neonicotinoid groups of insecticides. The indiscriminate use of imidacloprid is contaminating large water bodies affecting not only the ta...
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TiO2 nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish (Danio rerio) embryos Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-14 Rajaduraipandian Subramanian, Mohemedibrahim Ponnanikajamideen, Rapael Samuel Rajendran, Mohammed Ali Alshehri, Abdulrahman Alasmari, Chellasamy Panneerselvam, Selvendiran Periyasamy
The present study was designed to green synthesize titanium dioxide nanoparticles (G-TiO2 NPs) using Salacia reticulata leaf extract as a reducing and capping agent to assess antidiabetic, anti-inf...
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Artesunate does not affect oocyte maturation and early embryo development of bovine Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-08 Priscila Di Paula Bessa Santana, Tatiana Cristina Mota, Marcela Oliveira Das Mercês, Eduardo Baia De Souza, Nathalia Nogueira Da Costa De Almeida, Marcela Da Silva Cordeiro, Simone Do Socorro Damasceno Santos, Marcelo De Oliveira Bahia, Moysés Dos Santos Miranda, Otávio Mitio Ohashi
Abstract Despite the cytotoxicity and embryotoxicity previously reported artesunate is a recommended drug to treat malaria for adults, children, and women in the first trimester of pregnancy. To address the putative effects of artesunate on female fertility and preimplantation embryo development, when the pregnancy is not detectable yet, artesunate was added to the oocyte in vitro maturation and in
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Evaluation of oxidative stress and its association with drug therapy in inpatients treated for cocaine dependence Drug Chem. Toxicol. (IF 2.6) Pub Date : 2023-06-01 Isabela Lorini Franciscatto, Bruna Scherer Seibert, Samuel Selbach Dries, Rafael Linden, Ana Luiza Ziulkoski, Magda Susana Perassolo
Abstract The use of cocaine affects several systems and organs of the human body and the consumption of this substance leads to an increase in the production of reactive oxygen species, and to the reduction of antioxidant defenses. The aim of this study was to evaluate the oxidative stress (OS), biochemical and hematological parameters in patients hospitalized for treatment of cocaine addiction, comparing