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GW9508 ameliorates cognitive dysfunction via autophagy pathway in streptozotocin‐induced mouse model of Alzheimer's disease Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-03-15 Yanan Wang, Jingjing Chen, Chen Wang, Tong Chen, Ling He
BackgroundG protein‐coupled receptor 40 (GPR40) is a potential drug target for Alzheimer's disease (AD), and its agonist GW9508 ameliorates cognitive impairment by intravenous administration.ObjectivesThe present study was conducted to investigate the efficacy of GW9508 administered peripherally on cognitive dysfunction in streptozotocin (STZ)‐induced AD mice.MethodsSeventy male ICR mice were randomly
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Intradermal testing of iodinated contrast media: Should we test up to pure or with diluted compounds only? Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-03-14 Adrian A. Schmid, Martin N. Hungerbühler, Paolo Lombardo, Ingrid B. Boehm
BackgroundIntradermal testing (IDT) with iodinated contrast media (ICMs) is an established diagnostic tool in patients with ICM hypersensitivity. Currently, it is unclear which test concentration is the more useful one, up to pure or up to 1:10 diluted ICMs.MethodsWe searched the literature database PubMed for eligible papers dealing with ICM allergy and their IDT results. We analyzed the data presented
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Synergistic effects of epoxyazadiradione (EAD) and paclitaxel against triple‐negative breast cancer cells Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-03-14 Kunnathully Sudhan Sijisha, Rajitha Anusha, Sulochana Priya
BackgroundTriple‐negative breast cancer (TNBC) is the most aggressive and chemo‐resistant form of breast cancer subtype, and chemotherapy is a vital treatment option for that. Paclitaxel is an effective chemo drug for TNBC. However, in clinical settings, paclitaxel has adverse side effects. The synergistic combination is the most promising method for overcoming undesirable toxicity and achieving a
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Antimanic‐like effect of dipyridamole in the methylphenidate‐induced hyperlocomotion Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-03-13 Anderson Gustavo Santos, Carlos Eduardo Kühl, Arisa Namie Higashijima, Luiz Kae Sales Kanazawa, Suzen Tortato Furtado de Souza, Roberto Andreatini
BackgroundAdenosinergic system has been implicated in the pathophysiology of bipolar disorder and drugs that affect adenosine neurotransmission have shown some efficacy as add‐on therapy in manic patients.ObjectiveThus, the aim of the present study was to screen adenosinergic drugs for antimanic‐like effect in methylphenidate (MPH)‐induced hyperlocomotion in mice.MethodsMale and female Swiss mice received
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Challenges and opportunities of medicines for treating tendon inflammation and fibrosis: A comprehensive and mechanistic review Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-03-12 Zohreh Najafi, Pouria Rahmanian‐Devin, Vafa Baradaran Rahimi, Ali Nokhodchi, Vahid Reza Askari
BackgroundTendinopathy refers to conditions characterized by collagen degeneration within tendon tissue, accompanied by the proliferation of capillaries and arteries, resulting in reduced mechanical function, pain, and swelling. While inflammation in tendinopathy can play a role in preventing infection, uncontrolled inflammation can hinder tissue regeneration and lead to fibrosis and impaired movement
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Issue Information Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-03-12
No abstract is available for this article.
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Borolatonin limits cognitive deficit and neuron loss while increasing proBDNF in ovariectomised rats Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-29 Mónica Barrón-González, Astrid M. Rivera-Antonio, Rosa A. Jarillo-Luna, José M. Santiago-Quintana, David Levaro-Loquio, Teresa Pérez-Capistran, Christian H. Guerra-Araiza, Marvin A. Soriano-Ursúa, Eunice D. Farfán-García
Borolatonin is a potential therapeutic agent for some neuronal diseases such as Alzheimer's disease (AD). Its administration exerts ameliorative effects such as those induced by the equimolar administration of melatonin in behavioral tests on male rats and in neuronal immunohistochemistry assays.
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The role of β-adrenergic receptors in the regulation of cardiac tolerance to ischemia/reperfusion. Why do β-adrenergic receptor agonists and antagonists protect the heart? Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-29 Leonid N. Maslov, Natalia V. Naryzhnaya, Nikita S. Voronkov, Boris K. Kurbatov, Ivan A. Derkachev, Vyacheslav V. Ryabov, Evgeny V. Vyshlov, Viktor V. Kolpakov, Eugenia A. Tomilova, Ekaterina V. Sapozhenkova, Nirmal Singh, Feng Fu, Jianming Pei
Catecholamines and β-adrenergic receptors (β-ARs) play an important role in the regulation of cardiac tolerance to the impact of ischemia and reperfusion. This systematic review analyzed the molecular mechanisms of the cardioprotective activity of β-AR ligands.
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Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-20 Irmak Dik, Burak Dik, Öznur Tufan, Ayşe Er
Fish skin mucus contains innate immune factors and acts as the first line of physical or chemical defense against pathogens.
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Patterns of ketamine use among people with substance use disorder in France: Multisource analysis of the data from the French Addictovigilance Network Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-19 Pauline Gandolfo, Thomas Soeiro, Élisabeth Jouve, Bruno Revol, Amélie Daveluy, Célian Bertin, Céline Eiden, Valérie Gibaja, Leila Chaouachi, Marie‐Christine Pérault‐Pochat, Cécile Chevallier, Aurélie Aquizérate, Reynald Le Boisselier, Louise Carton, Maryse Lapeyre‐Mestre, Élisabeth Frauger, Clémence Lacroix, Joëlle Micallef
BackgroundDue to its psychoactive effects, ketamine has become a drug used for non‐medical purpose.ObjectivesTo assess the latest trends in ketamine use among people with substance use disorder and to characterize its clinical complications using complementary health data sources of the French Addictovigilance Network.MethodsFirst, we extracted all reports involving ketamine from 2012 to 2021 from
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Targeting mevalonate pathway by zoledronate ameliorated pulmonary fibrosis in a rat model: Promising therapy against post-COVID-19 pulmonary fibrosis Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-15 Reham Hussein Mohamed, Nesma Hussein Abdel hay, Nesma Mohamed Fawzy, Yomna M. Tamim, M. M. Doaa Karem, Dalia Ahmed Yousef Yehia, Omnia M. Abdel Maksoud, Dina S. Abdelrahim
Rho kinase (ROCK) pathway plays a critical role in post-COVID-19 pulmonary fibrosis (PCPF) and its intervention with angiotensin-converting enzyme 2 (ACE2) and vascular endothelial growth factor (VEGF) will be a potential therapeutic target.
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Latest advances in the reversal strategies for direct oral anticoagulants Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-13 Jean Escal, Julien Lanoiselée, Géraldine Poenou, Paul Zufferey, Silvy Laporte, Patrick Mismetti, Xavier Delavenne
Since the late 2000s, Europe has granted approval for various thrombotic risk-related uses of direct oral anticoagulants (DOACs). Unlike traditional anticoagulants, DOACs do not necessitate routine coagulation monitoring. Nevertheless, clinical practice often encounters bleeding events associated with these medications, making the need for effective reversal strategies evident.
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Population pharmacokinetics and pharmacodynamics of nirmatrelvir in Chinese patients with COVID-19 Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-11 Liyan Zeng, Rui Chen, Xuhua Jiang, Feng Li, Zhaoqin Zhu, Zheng Jiao, Yun Ling, Lijun Zhang
The pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of nirmatrelvir (NMV) are unknown in Chinese patients with COVID-19.
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Comparison of agranulocytosis and anti-neutrophil cytoplasmic antibody-associated vasculitis caused by two antithyroid drugs: A pharmacovigilance study using the WHO international database Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-11 Ji Yun Han, Jun Myong Lee, Se Yong Jung, Min Seo Kim, Seung Won Lee, Andreas Kronbichler, Kalthoum Tizaoui, Ai Koyanagi, Eun Young Kim, Kyungchul Song, Hyun Wook Chae, Dong Keon Yon, Jae Il Shin, Lee Smith
Methimazole (MMI) and propylthiouracil (PTU) are commonly used for patients with thyrotoxicosis. Agranulocytosis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is associated with high morbidity and mortality, requiring appropriate interventions. In this study, we compared adverse drug effects associated with MMI and PTU using a real-world large pharmacovigilance database
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Ursodeoxycholic acid for preventing parenteral nutrition-associated cholestasis in neonates: A systematic review and meta-analysis Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-11 Rajendra Prasad Anne, Srikanth Puttaiah Kadyada, Abhishek Somasekhara Aradhya, Tejo Pratap Oleti
While ursodeoxycholic acid is used in treating parenteral nutrition-associated cholestasis (PNAC) in neonates, its role in prevention is unclear.
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Anticancer effect of propranolol on diethylnitrosamine-induced hepatocellular carcinoma rat model Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-07 Yomna M. Tamim, Ahmed A. Nagy, Ahmed M. Abdellah, Ahmed H. Osman, Amel F. M. Ismail
Hepatocellular carcinoma (HCC) is the most widespread type of primary liver cancer. Diethylnitrosamine (DEN), a hepatotoxic hepatocarcinogenic compound, is used to induce HCC in animal models. The non-selective β-blocker propranolol demonstrated antiproliferative activity in many cancer types.
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Angiotensin 1–7 increases cardiac tolerance to ischemia/reperfusion and mitigates adverse remodeling of the heart—The signaling mechanism Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-02-04 Ivan A. Derkachev, Sergey V. Popov, Leonid N. Maslov, Alexandr V. Mukhomedzyanov, Natalia V. Naryzhnaya, Alexander S. Gorbunov, Artur Kan, Andrey V. Krylatov, Yuri K. Podoksenov, Ivan V. Stepanov, Svetlana V. Gusakova, Feng Fu, Jian-Ming Pei
The high mortality rate of patients with acute myocardial infarction (AMI) remains the most pressing issue of modern cardiology. Over the past 10 years, there has been no significant reduction in mortality among patients with AMI. It is quite obvious that there is an urgent need to develop fundamentally new drugs for the treatment of AMI. Angiotensin 1–7 has some promise in this regard.
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Role of biomarkers and molecular signaling pathways in acute lung injury Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-26 Pakter Niri, Achintya Saha, Subramanyam Polopalli, Mohit Kumar, Sanghita Das, Pronobesh Chattopadhyay
Acute lung injury (ALI) is caused by bacterial, fungal, and viral infections. When pathogens invade the lungs, the immune system responds by producing cytokines, chemokines, and interferons to promote the infiltration of phagocytic cells, which are essential for pathogen clearance. Their excess production causes an overactive immune response and a pathological hyper-inflammatory state, which leads
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Effect of spermidine on long non-coding RNAs MALAT1 in a rotenone induced-rat model of Parkinson's disease Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-26 Noha Mohamed Badae, Doaa A. Abdelmonsif, Rania Gaber Aly, Amira M. Omar, Mai S. Shoela, Eman M. Omar
Spermidine is a natural biologically active substance that has widespread influences on the body.
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Issue Information Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-25
No abstract is available for this article.
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Arterial hypertension associated with PARPi: A meta-analysis of 41 placebo randomized controlled trials combined with a World Health Organization's pharmacovigilance study Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-25 Clémence Blaize, Ellina Surtouque, Jonaz Font, Charles Dolladille, Sophie Postel-Vinay, Angélique Da Silva, Joachim Alexandre, Pierre-Marie Morice
Arterial hypertension has been recently reported from randomized controlled trials (RCTs) assessing poly (ADP-ribose) polymerase inhibitor (PARPi).
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Sodium hypochlorite accident diagnosis and management: Analysis from the literature and the French pharmacovigilance database Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-24 Zahoua Kartit, Céline Delacroix, Céline Clement, Mathilde Beurrier, Claudie Mouton-Faivre, Nadine Petitpain
Sodium hypochlorite (NaOCl) is considered as the reference irrigation solution in endodontics. However, NaOCl-related accidents may occur, and non-dentist health professionals might under-recognize this rare adverse effect although it is potentially severe, with possible medical and aesthetic sequelae. We performed a literature review to provide to non-dentist healthcare professionals a large picture
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Repurposing of atorvastatin and metformin denotes their individual and combined antiproliferative effects in non-small cell lung cancer Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-23 Elsayed I. Salim, Safaa Elsebakhy, Mohamed Hessien
Due to the limited success in the treatment of lung adenocarcinomas, new treatment protocols are urgently needed to increase the curability rate and the survival of lung cancer patients.
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Probing polypharmacy, ageing and sex effects on physical function using different tests Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-21 Gizem Gemikonakli, John Mach, Trang Tran, Harry Wu, Sarah N. Hilmer
Ageing, sex and polypharmacy affect physical function.
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Cell–cell communication in stem cells and cancer: Alone but in touch Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-16 Mehran Radak, Hossein Fallahi
Cellular communication and signaling pathways are fundamental regulators of stem cell and cancer cell behaviors. This review explores the intricate interplay of these pathways in governing cellular behaviors, focusing on their implications for diseases, particularly cancer.
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Update on monkeypox virus infection: Focusing current treatment and prevention approaches Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-16 Rishika Dhapola, Sneha Kumari, Prajjwal Sharma, Pramod KumarKushawaha, Dibbanti HariKrishnaReddy
While the world is still facing the global pandemic COVID-19, another zoonosis monkeypox (Mpox) has emerged posing a great threat to society. Insight into the pathogenesis, symptoms, and management strategies will aid in the development of potent therapeutics for the treatment of monkeypox virus infection.
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Impacts of genetic polymorphisms and cancer cachexia on naldemedine pharmacokinetics and bowel movements in patients receiving opioid analgesics Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2024-01-08 Emi Nakatsugawa, Takafumi Naito, Kaito Shibata, Ryo Kitajima, Junichi Kawakami
Clinical responses to naldemedine vary between individuals with advanced cancer. This is a prospective, single-center, observational study aimed to evaluate the influence of genetic polymorphisms and cachexia status on plasma naldemedine and clinical responses.
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The comparison of the antidiabetic effects of exenatide, empagliflozin, quercetin, and combination of the drugs in type 2 diabetic rats Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-12-27 Yasemin Korkmaz, Burak Dik
Type 2 diabetes, a metabolic disease that involves extended treatment, is rapidly increasing in humans and animals worldwide.
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Antimalarial activities of benzothiazole analogs: A systematic review Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-12-26 Linh Tran, Vo Linh Tu, Mohammad Najm Dadam, Jeza Muhamad Abdul Aziz, Tran Le Dinh Duy, Hajer Hatim Hassan Ahmed, Patrick Amanning Kwaah, Hoang Nghia Quoc, Truong Van Dat, Satoshi Mizuta, Kenji Hirayama, Nguyen Tien Huy
Benzothiazole derivatives have been reported to possess a wide range of biological activities, including antimalarial activity. This systematic review aims to summarize and evaluate the antimalarial activities of benzothiazole analogs.
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Lacosamide use during breastfeeding: A case report and a literature review Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-12-06 Morgan Cercos, Ines Seqat, Anthony Facile, Thierry Vial, Marine Auffret
Lacosamide, a voltage-gated sodium channel inhibitor, is an anti-seizure medication (ASM) from the age of 4. We report on the case of a woman treated with lacosamide for pharmacoresistant epilepsy who breastfed her infant for more than 6 months after birth. The infant's blood concentrations of lacosamide were 2.4 mg/L on Day 1 and less than 1 mg/L on Day 10 (reference values are 1–10 mg/L). No adverse
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Effect of Bacille-Calmette-Guerin vaccine against rotenone-induced Parkinson's disease: Role of neuroinflammation and neurotransmitters Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-12-02 Narhari Gangaram Yedke, Divya Soni, Puneet Kumar
Parkinson's disease (PD) is an extrapyramidal movement disorder associated with a hypokinetic condition generated by impairment in dopaminergic neuronal viability in the nigrostriatal region of the brain. Current medications can only provide symptomatic management; to date, no permanent cure is available. To compensate for this lacuna, researchers are gaining interest in antigen-based therapy, and
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Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-27 Elizabeth W. Covington, Shaneese L. Jasper-Trotter, Robert D. Arnold, Raj Amin, Susan Egbert, Allison Chung
Vitamin D deficiency is a common finding in critically ill children. However, the optimal supplementation strategy in this patient population is unknown. The objective of this study was to evaluate the effects of high-dose (10 000 IU/kg, max. 400 000 IU) vitamin D supplementation on 25-hydroxyvitamin D3 (25[OH]D3) levels in pediatric intensive care unit (PICU) patients with baseline vitamin D deficiency
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Association between immune-related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-27 Romain Euvrard, Marie Robert, Sabine Mainbourg, Stéphane Dalle, Jean-Christophe Lega
Immune checkpoint inhibitors (ICI) represent a breakthrough in oncology in terms of prognosis and safety. They now constitute a cornerstone in the management of metastatic melanoma. However, a new kind of adverse event called immune-related adverse events (irAE) has emerged. These irAE could be conceptually considered as an indicator of the antitumoral immune response, but the association between irAE
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Chlorogenic acid co-administration alleviates cisplatin-induced peripheral neuropathy in rats Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-23 Çiğdem Çengelli Ünel, Ezgi Eroğlu, Orhan Özatik, Kevser Erol
Chemotherapy-induced peripheral neuropathy (CIPN) is still an unresolved problem in cisplatin (CIS) use.
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Issue Information Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-21
No abstract is available for this article.
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Myrtenal exhibits cardioprotective effects by attenuating the pathological progression associated with myocardial infarction Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-21 N Abhirami, Mahesh Chandran, Athira Ramadasan, Dhanalekshmi Bhasura, Janeesh Plakkal Ayyappan
Myocardial infarction poses major risks to human health because of their incredibly high rates of morbidity and mortality. Infarctions are more likely to develop as a result of dysregulation of cell death. Myrtenal can be considered for their bioactive beneficial activity in the context of cardiovascular pathologies and, particularly, in the protection toward oxidative stress followed by ischemic injury
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An exploratory study of drug concentration and inhibitory effect of cetylpyridinium chloride buccal tablets on SARS-CoV-2 infection among 10 Chinese subjects Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-20 Yanting Li, Zhenwei Xie, Liming Chen, Xiangxing Liu, Shuang Li, Shichun Ye, Hongyan Tang, Chongyou Lee, Qun Gu, Fang Men, Jiaojiao Zhang, Dingyuan Hu, Yuanli Jiang, Xiaochun Wang, Qian Wang, Yufei Feng, Suping Niu, Yan Liu, Yi Fang
It was evidenced that cetylpyridinium-chloride (CPC) mouthwash could inhibit SARS-COV-2 activity and reduce salivary viral load, thus reducing SARS-CoV-2 transmission. However, due to insufficient residence time in the oral cavity, CPC-containing mouthwashes have no prolonged antiviral effect. The duration of action of the CPC buccal tablet is expected to be longer than that of the mouthwash. However
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In vitro stability study of 10 beta-lactam antibiotics in human plasma samples Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-20 Matthieu Brenkman, Tom Cartau, Elise Pape, Allan Kolodziej, Alexandre Charmillon, Emmanuel Novy, Jean-Yves Jouzeau, Nicolas Gambier, Julien Scala-Bertola
Beta-lactam antibiotics are reported for some of them to be subject to a rapid degradation in infusion solutions and in human blood samples. However, the current data of stability available in blood samples are limited to a few number of beta-lactam antibiotics, and the methodology of the corresponding studies may be discussed. The objective of the present study is to evaluate the stability of 10 beta-lactam
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Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini-review on availability and limitations Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-15 Monika Berezowska, Pradeep Sharma, Venkatesh Pilla Reddy, Paola Coppola
Physiologically based pharmacokinetic (PBPK) modelling in pregnancy is a relatively new approach that is increasingly being used to assess drug systemic exposure in pregnant women to potentially inform dosing adjustments. Physiological changes throughout pregnancy are incorporated into mathematical models to simulate drug disposition in the maternal and fetal compartments as well as the transfer of
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Alterations in the gene expression of SARS-COV-2 entry receptors and enzymes in lungs and hearts of controlled and uncontrolled diabetic mice Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-10 Ohood Alkhawaldeh, Yazun Jarrar, Munir Gharaibeh, Sara Abudahab, Dina Abulebdah, Bashir Jarrar
The entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is carried out by specific receptors and enzymes, including human angiotensin-converting enzyme 2 receptor (ACE2), transmembrane serine protease 2 (TMPRSS2), and cathepsin-L (CTSL). COVID-19 patients with comorbidities, such as diabetes mellitus (DM), are more prone to severe symptoms and have a higher
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Cardiac and hepatic side effects of fluoxetine in male and female adolescent rats Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-11-08 Hajar Babaaeyan, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadati, Ali Niapour
Fluoxetine (FLX) is widely prescribed as an antidepressant medicine in the juvenile population.
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Analgesic switching in chronic users of dextropropoxyphene in France Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-10-21 Amélie Daveluy, Michael Charles Bryan, Ghada Miremont-Salamé, Régis Lassalle, Clémentine Lacueille, Angela Grelaud, Marie Floccia, Françoise Haramburu, Maryse Lapeyre-Mestre, Joëlle Micallef, Francesco Salvo
The combination dextropropoxyphene/paracetamol (DXP/P) was the most prescribed opioid analgesic until its withdrawal in 2011.
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Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-10-19 Zhikal Omar Khudhur, Shang Ziyad Abdulqadir, Abdullah Faqiyazdin Ahmed Mzury, Abdulrahman Aziz Rasoul, Shukur Wasman Smail, Mohammad B. Ghayour, Arash Abdolmaleki
Epothilone B (EpoB) is a microtubule-stabilizing agent with neuroprotective properties.
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Synthesis, molecular docking, ADMET, and evaluation of the anxiolytic effect in adult zebrafish of synthetic chalcone (E)-3-(4-(dimethylamino)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one: An in vivo and in silico approach Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-10-16 Larissa Santos Oliveira, Maria Kueirislene Amâncio Ferreira, Francisco Wagner de Queiroz Almeida-Neto, Antonio Wlisses da Silva, José Ivo Lima Pinto Filho, Matheus Nunes da Rocha, Emanuelle Machado Marinho, Walber Henrique Ferreira Ribeiro, Márcia Machado Marinho, Emmanuel Silva Marinho, Jane Eire Silva Alencar de Menezes, Hélcio Silva dos Santos
Anxiety disorders represent the complex interaction between biological, psychological, temperamental, and environmental factors; drugs available to treat anxiety such as benzodiazepines (BZDs) are associated with several unwanted side effects. Although there are useful treatments, there is still a need for more effective anxiolytics with better safety profiles than BZDs. Chalcones or 1,3-diphenyl-2-proper-1-ones
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Exploring signals of myopathy associated with statin and contraindicated comedications in the realworld Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-10-11 Sewon Park, Ju Won Lee, Dal Ri Nam, Sun-Young Jung
Using statins in combination with other drugs was reported to increase the risk of myopathy. However, there was a sparse number of studies on the incidence of adverse events (AEs) associated with the concomitant use of statin and contraindicated drugs in the real world.
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Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-10-04 Ivana Šušak Sporiš, Nada Božina, Iva Klarica Domjanović, Davor Sporiš, Silvio Bašić, Ivana Bašić, Mila Lovrić, Lana Ganoci, Vladimir Trkulja
Valproate inhibits clearance of lamotrigine and greatly increases its concentrations. We assessed whether this effect was moderated by a polymorphism (ABCG2 c.421C>A) of the breast cancer resistance protein.
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Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-27 Maryam Golmohammadi, Mohammadreza Mahmoudian, Ekhlas Khammas Hasan, Shadia Hamoud Alshahrani, Rosario Mireya Romero-Parra, Jitendra Malviya, Ahmed Hjazi, Mazin A. A. Najm, Abbas F. Almulla, Mohammad Yasin Zamanian, Mona Kadkhodaei, Nazanin Mousavi
Despite several hundred clinical trials of drugs that initially showed promise, there has been limited clinical improvement in Alzheimer's disease (AD). This may be attributed to the existence of at least 25 abnormal cellular pathways that underlie the disease. It is improbable for a single drug to address all or most of these pathways, thus even drugs that show promise when administered alone are
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Evaluation of anti-inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-21 Ricardo Andrade Furtado, Samir A. Ross, Silvio de Almeida Junior, Rafael Paranhos de Mendonça, Cristiane Teixeira Vilhena Bernardes, Mauro Nogueira da Silva, Karina Furlani Zoccal, Lúcia Helena Faccioli, Jairo Kenupp Bastos
Kaurenol, a diterpene alcohol found in Copaifera langsdorffii Desf. (known as “copaiba”), is historically used in traditional medicine for inflammatory conditions.
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Changes in serotonin neurotransmission as assayed by microdialysis after acute, intermittent or chronic ethanol administration and withdrawal Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-15 Abdelkader Dahchour, Roberta J. Ward
The serotonergic neurotransmitter system is involved in many ethanol-induced changes, including many behavioural alterations, as well as contributing to alcohol dependence and its withdrawal.
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The state of astragaloside IV research: A bibliometric and visualized analysis Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-12 Ning Liu, Yansu Ji, Rui Liu, Xin Jin
Astragaloside IV has emerged as a pharmaceutical monomer with great medical applications and potential. Astragaloside IV has many effects such as improving myocardial ischemia, cerebral ischemia–reperfusion injury, anti-inflammatory, analgesic, antiviral, promoting lymphocyte proliferation, and antitumor effects. However, there are few bibliometric studies on astragaloside IV.
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A systematic strategy for investigating the pharmacological effects and mechanism of traditional Chinese medicinal formula: Guilin Xiguashuang as a case Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-11 Jianing Zhang, Yue Ren, Yanan Liu, Zian Wang, Yingying Li, Chun Li, Hua Chang, Yanling Zhang
Traditional Chinese medicinal formula (TCMF) has specific advantages in treating diseases. However, the pharmacological effects and mechanism of TCMF composed of traditional Chinese medicines (TCM) with unclear active components or targets have not yet been fully elucidated.
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Issue Information Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-08
No abstract is available for this article.
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Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug-induced liver injury Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-04 Julien Allard, Simon Bucher, Pierre-Jean Ferron, Youenn Launay, Bernard Fromenty
The antineoplastic drug busulfan can induce different hepatic lesions including cholestasis and sinusoidal obstruction syndrome. However, hepatic steatosis has never been reported in patients.
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Adenosine monophosphate-regulated protein kinase inhibition modulates electrophysiological characteristics and calcium homeostasis of rabbit right ventricular outflow tract Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-09-04 Yen-Yu Lu, Chen-Chuan Cheng, Yao-Chang Chen, Yung-Kuo Lin, Satoshi Higa, Yu-Hsun Kao, Yi-Jen Chen
Metabolic stress predisposes to ventricular arrhythmias and sudden cardiac death. Right ventricular outflow tract (RVOT) is the common origin of ventricular arrhythmias. Adenosine monophosphate-regulated protein kinase (AMPK) activation is an important compensatory mechanism for cardiac remodeling during metabolic stress.
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Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre-eclampsia Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-08-31 Rebecca Reddy, Sooraj Baijnath, Sanil Singh, Roshila Moodley, Thajasvarie Naicker, Nalini Govender
Hesperidin, a flavanone commonly found in citrus fruits and herbal formulations, has emerged as a potential new therapeutic agent for modulating several diseases. Since pre-eclampsia is a growing public health threat, it may negatively impact the economy and increase the disease burden of South Africa. Phytocompounds are easily accessible, demonstrate minimal side effects, and may confer novel medicinal
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Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-08-30 Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Isaac Moura Araújo, Gustavo Miguel Siqueira, João Arthur de Oliveira Borges, Daniel Sampaio Alves, Gustavo Marinho Miranda, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Helcio Silva dos Santos, Saulo
Thiadiazines are heterocyclic compounds that contain two nitrogen atoms and one sulfur atom in their structure. These synthetic molecules have several relevant pharmacological activities, such as antifungal, antibacterial, and antiparasitic.
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Preliminary evaluation of the efficacy and safety of brimonidine for deep sedation Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-08-23 Xiaohui Wang, Rui Zhang, Bin Chen, Ting Zhang, Xinghua Jin, Ping Gao
Although brimonidine is currently used in the clinical treatment of glaucoma and rosacea, research of the deep sedative effect on animals after systemic administration is reported firstly and has shown promising results.
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Human neutrophil elastase inhibitors: Classification, biological-synthetic sources and their relevance in related diseases Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-08-23 Jhonnatan Styver Ocampo-Gallego, David Pedroza-Escobar, Ana Ruth Caicedo-Ortega, María Teresa Berumen-Murra, Ana Lucía Novelo-Aguirre, Rebeca Denis de Sotelo-León, Dealmy Delgadillo-Guzmán
Human neutrophil elastase is a multifunctional protease enzyme whose function is to break the bonds of proteins and degrade them to polypeptides or amino acids. In addition, it plays an essential role in the immune mechanism against bacterial infections and represents a key mediator in tissue remodeling and inflammation. However, when the extracellular release of this enzyme is dysregulated in response
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Role of apoptosis and autophagy in folic acid-induced cytotoxicity of human breast cancer cells in vitro Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-08-16 Munevver Baran, Gozde Ozge Onder, Ozge Goktepe, Arzu Yay
Obstacles to the successful treatment of breast cancer patients with chemotherapeutic agents can be overcome with effective new strategies. It is still unclear how folic acid affects the onset and spread of breast cancer. The purpose of this study was to determine how folic acid affected the apoptotic and autophagic pathways of the breast cancer cell lines MCF-7 and MDA-MB-231. In the present study
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Can cannabidiol have an analgesic effect? Fund. Clin. Pharmacol. (IF 2.9) Pub Date : 2023-08-16 Bartłomiej Kulesza, Marek Mazurek, Jacek Kurzepa
Cannabis, more commonly known as marijuana or hemp, has been used for centuries to treat various conditions. Cannabis contains two main components cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD, unlike THC, is devoid of psychoactive effects and is well tolerated by the human body but has no direct effect on the receptors of the endocannabid system, despite the lack of action on the receptors