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Improvement of inhaled paraquat induced lung and systemic inflammation, oxidative stress and memory changes by safranal Toxicon (IF 2.8) Pub Date : 2024-03-12 Sima Beigoli, Ali Asghar Hajizadeh, Mohammad Ehsan Taghavizadeh Yazdi, Reyhaneh Khosravi, Farzaneh Vafaee, Mohammad Hossein Boskabady
The effects of safranal and pioglitazone alone and their combination on inhaled paraquat (PQ)-induced systemic oxidative stress and inflammation as well as behavioral changes were examined in rats. In this study, animals were exposed to saline (Ctrl) or PQ (PQ groups) aerosols. PQ exposed animals were treated with dexamethasone, 0.8 and 3.2 mg/kg/day safranal (Saf-L and Saf-H), 5 mg/kg/day pioglitazone
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The effects of CDP-choline treatment in Amanita phalloides mushroom toxicosis Toxicon (IF 2.8) Pub Date : 2024-03-12 Nuri Cenk Coskun, Seyma Buyucek
poisoning is known to be the most fatal case among mushroom poisoning cases. Its main mechanism of toxicity is that it leads to cell death by the irreversible binding of its toxins to the DNA-dependent RNA polymerase II enzyme. This study was planned to analyze the effects of the CDP-choline molecule on mushroom poisoning cases.
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Capacity of community health centers to treat snakebite envenoming in indigenous territories of the Brazilian Amazon Toxicon (IF 2.8) Pub Date : 2024-03-10 André Sachett, Eleanor Strand, Thiago Serrão-Pinto, Alexandre da Silva Neto, Thais Pinto Nascimento, Sewbert Rodrigues Jati, Gisele dos Santos Rocha, Sediel Ambrósio Andrade, Fan Hui Wen, Manuela Berto Pucca, João Vissoci, Charles J. Gerardo, Jacqueline Sachett, Altair Seabra de Farias, Wuelton Monteiro
The deaths from and morbidities associated with snakebites - amputations, loss of function in the limb, visible scarring or tissue damage - have a vast economic, social, and psychological impact on indigenous communities in the Brazilian Amazon, especially children, and represent a real and pressing health crisis in this population. Snakebite clinical and research experts have therefore proposed expanding
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Astaxanthin treatment reduces kidney damage and facilitates antioxidant recovery in lithium-intoxicated rats Toxicon (IF 2.8) Pub Date : 2024-03-08 Elif Erbaş, Hilal Üstündağ, Emre Öztürk, Seçil Nazife Parlak, Tuğçe Atcalı
This study aimed to evaluate the protective effects of astaxanthin against lithium-induced nephrotoxicity, focusing on histopathological changes, oxidative stress modulation, and alteration in the expression of key proteins related to apoptosis and inflammation. In this study, 56 male rats were utilized and divided into experimental groups subjected to lithium-induced nephrotoxicity, with and without
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The establishment and evaluation of a swine model of deinagkistrodon acutus snakebite envenomation Toxicon (IF 2.8) Pub Date : 2024-03-07 Linjie Lai, Xie Lutao, Yi Chen, Wang Du, Xuelin Yang, Wanjuan Liu, Peixin Shangguan, Jiefeng Xu, Pin Lan
To establish a preclinical large-animal model of snakebite envenomation and evaluate its feasibility. The venom of (0 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg, or 10 mg/kg) was injected into the left biceps femoris of 11 male pigs. Then, the circumferences of the limbs were regularly measured, and changes in muscle injury biomarkers, blood parameters, coagulation function, vital organ function and injury biomarkers
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Long-term hospital care needs after Bothrops atrox envenomation with hemorrhagic stroke in the Brazilian Amazon: ‘From social to physical death’ – A case report Toxicon (IF 2.8) Pub Date : 2024-03-07 Thaís Pinto Nascimento, Talyson Aparicio Gomes, Bárbara Juliana Carvalho Costa, Erica Carvalho, Amanda Braga Cunha, Bianca Leite Pereira, Marco Aurélio Sartim, Felipe Leão Gomes Murta, Wuelton Monteiro, Jacqueline de Almeida Gonçalves Sachett
Hemorrhagic stroke is a severe complication reported in cases of snakebite envenomation. We report an unusual case of a patient who evolved with an intracranial hemorrhagic stroke and was in a coma for more than five years in a tertiary hospital located in Manaus, Amazonas. 52-year-old man, carpenter, resident in the rural area of the municipality of Tabatinga, located 1106 km from Manaus, capital
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Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression Toxicon (IF 2.8) Pub Date : 2024-03-06 Hesham A. El-Beshbishy, Dania S. Waggas, Rabab A. Ali
Bisphenol A (BPA) engenders testicular toxicity hydroxyl free radical genesis in rat striatum and depletion of the endogenous antioxidants in the epididymal sperms. The multi-drug resistance efflux carrier; P-glycoprotein (P-gp) expel the BPA from the testis and is responsible for the testicular protection through the deactivation of numerous xenobiotics. In our study, we investigated whether the BPA-induced
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Biochemical and toxicological profiles of venoms from an adult female South American bushmaster (Lachesis muta rhombeata) and her offspring Toxicon (IF 2.8) Pub Date : 2024-03-05 Nathália C. Galizio, Laura S. Moraes-Santos, Ana C. Yabunaka, Poliana J. Demico, Kristian A. Torres-Bonilla, Julian C.G. Varón, Nelson J.da Silva Jr, Anita M. Tanaka-Azevedo, Marisa M.Teixeira da Rocha, Stephen Hyslop, Rafael S. Floriano, Karen de Morais-Zani
In this work, we compared the biochemical and toxicological profiles of venoms from an adult female specimen of (South American bushmaster) and her seven offspring born in captivity, based on SDS-PAGE, RP-HPLC, enzymatic, coagulant, and hemorrhagic assays. Although adult and juvenile venoms showed comparable SDS-PAGE profiles, juveniles lacked some chromatographic peaks compared with adult venom. Adult
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β-keto amyrin isolated from Cryptostegia grandiflora R. br. inhibits inflammation caused by Daboia russellii viper venom: Direct binding of β-keto amyrin to phospholipase A2 Toxicon (IF 2.8) Pub Date : 2024-03-05 K.H. Santhosh, V. Krishna, K. Kemparaju, H. Manjunatha, R. Shashi Kumar, A. Mukherjee, S.E. Gomez Mejiba, D.C. Ramirez, B.S. Ravindranath
The search for mechanism-based anti-inflammatory therapies is of fundamental importance to avoid undesired off-target effects. Phospholipase A (PLA) activity is a potential molecular target for anti-inflammatory drugs because it fuels arachidonic acid needed to synthesize inflammation mediators, such as prostaglandins. Herein, we aim to investigate the molecular mechanism by which β-keto amyrin isolated
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Real-world differences in dosing and clinical utilization of OnabotulinumtoxinA and AbobotulinumtoxinA in the treatment of upper limb spasticity Toxicon (IF 2.8) Pub Date : 2024-03-04 Zachary Bohart, Khashayar Dashtipour, Heakyung Kim, Marc Schwartz, Aleks Zuzek, Ritu Singh, Mariana Nelson
According to prescribing information, potency units are not interchangeable between botulinum toxin A products. This exploratory study compared real-world dosing and utilization of onabotulinumtoxinA and abobotulinumtoxinA in adults with upper limb spasticity. In this retrospective study, 101 clinicians provided chart data via online surveys for 215 US post-stroke patients treated for upper limb spasticity
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Morusin suppresses the stemness characteristics of gastric cancer cells induced by hypoxic microenvironment through inhibition of HIF-1α accumulation Toxicon (IF 2.8) Pub Date : 2024-03-01 Mo Chen, Shufeng Xiao, Ping Sun, Yongfu Li, Zhixing Xu, Jun Wang
Gastric cancer (GC) is a common, life-threatening malignancy that contributes to the global burden of cancer-related mortality, as conventional therapeutic modalities show limited effects on GC. Hence, it is critical to develop novel agents for GC therapy. Morusin, a typical prenylated flavonoid, possesses antitumor effects against various cancers. The present study aimed to demonstrate the inhibitory
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Highly in vitro anti-cancer activity of melittin-loaded niosomes on non-small cell lung cancer cells Toxicon (IF 2.8) Pub Date : 2024-03-01 Pooyan Honari, Delavar Shahbazzadeh, Mahdi Behdani, Kamran Pooshang Bagheri
Development of promising medicines from natural sources, specially venom, is of highly necessitated to combat against life-threatening cancers. Non-small cell lung cancer (NSCLC) has a significant percentage of mortalities. Melittin, from bee venom, is a potent anticancer peptide but its toxicity has limited its therapeutic applications. Accordingly, this study aims to synthesize niosomes with suitable
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Characterization of an antimicrobial peptide family from the venom gland of Heteropoda venatoria Toxicon (IF 2.8) Pub Date : 2024-02-29 Zhihao Peng, Chao Wei, Jisen Cai, Zhaoxia Zou, Jinjun Chen
Spider venom boasts extensive peptide diversity, constituting a natural biochemical arsenal for defense and predation. The new family HvAMPs, including 9 homologous members, were identified from the unnormalized cDNA library of venom gland by Sanger sequencing. The putative mature peptide is composed of 22 aliphatic amino acid residues. The mature peptides of HvAMP1 and HvAMP5, with 3 different amino
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Fatal Africanized bee attack in captive non-human primates (Saimiri ustus and Sapajus libidinosus) Toxicon (IF 2.8) Pub Date : 2024-02-28 Isabel Luana de Macêdo, Davi Emanuel Ribeiro de Sousa, Antonizete dos Reis Souza, Aníbal G. Armién, Mizael Machado, Márcio Botelho de Castro
Bee stings (BS) are a life-threatening issue and a growing concern for public health and animals in the Americas. We describe the clinical, pathological, and ultrastructural findings of a massive lethal bee attack in two non-human primates (NHPs). Both animals showed BS scattered throughout the skin, surrounded by a local reaction, diffuse pulmonary congestion, edema, hemorrhage, and remarkable degeneration
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High-grain feeding contributes to endotoxin contamination in dairy milk Toxicon (IF 2.8) Pub Date : 2024-02-28 S. Aditya, M. Qumar, M.F. Karimy, P. Pourazad, F. Penagos-Tabares, N. Wulansari
To support milk production and milk quality, ruminant animals like dairy cows are particularly fed using concentrate containing high grain and starch. Nonetheless, this type of regimen feeding could induce subacute rumen acidosis condition. Then, these circumstances cause the lysis of gram-negative bacteria accompanied by endotoxin release in gut. More importantly, gut endotoxin could be translocated
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Evaluation of the toxicological effects of Neltuma alpataco (Prosopis alpataco) pod alkaloid extract Toxicon (IF 2.8) Pub Date : 2024-02-28 Luciana Cholich, María Pistán, Angelica Cabrera Benítez, Ana Torres, Enrique Nicolas García, Agustín Martinez, Dale Gardner, Soledad Bustillo
The pods of spp. have shown potential as a source of protein and energy in livestock. However, prolonged consumption of some of these species can lead to neurological symptoms in ruminants. This study aimed to determine the alkaloid content, as well as the and effects of an alkaloid-enriched extract (AEE) from pods High performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS)
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Comparative analysis of Deinagkistrodon acutus venom from Taiwan and China utilizing chromatographic, electrophoretic, and bioinformatic approaches, along with ELISA employing a monospecific antivenom Toxicon (IF 2.8) Pub Date : 2024-02-28 Tein-Shun Tsai, Inn-Ho Tsai, Jing-Lin Qiu, Yuen-Ying Chan, Yu-Wei Chiang
is a medically important pitviper inhabiting mainly South China and Taiwan. The hemorrhagic effects of its envenoming are compatible to its venom, which is abundant in metalloproteases (svMPs) and C-type lectin-like proteins. In this study, we investigated geographic variations in the venom of collected from Taiwan and four Mainland Chinese provinces: Fujian, Jiangxi, Anhui, and Hunan. The variations
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Evaluation of venom diversity and antivenom quality from the venom of long-term captive vs recently wild captured Pseudocerastes persicus snake: An In vitro and In vivo study Toxicon (IF 2.8) Pub Date : 2024-02-27 Kiumars Bahmani, Adel Abdollahnia, Hossein Vatenpour, Alireza Ghassempour, Mohammad Kaboli, Mohammad reza Shahidi
Snakebite envenomation is a life-threatening condition and antivenoms are used as the most effective treatment. Venom obtained from snakes in long-term captivity showed some variations in comparison to the venom of the wild snakes. The objective of this study is to compare the venom of the under long-term captivity and wild conditions as well as the antivenom obtained from these venoms. We have analyzed
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Biodistribution of radiolabeled alpha-amanitin in mice: An Investigation Toxicon (IF 2.8) Pub Date : 2024-02-24 Kubra Durkan, Cigdem Ichedef, Elif Baris, M. Aylin Arici
Mushroom poisonings caused by Amanita phalloides are the leading cause of mushroom-related deaths worldwide. Alpha-Amanitin (α-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The objective of our study was to determine the distribution of α-AMA in Balb/c mice by labeling with Iodine-131.
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Ameliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity Toxicon (IF 2.8) Pub Date : 2024-02-24 Zeynep Erdemli, Mehmet Gul, Nurcan Gokturk, Elif Kayhan, Nursena Demircigil, Eda Nur Ozsoy, Harika Gozukara Bag, Mehmet Erman Erdemli
First in the literature this study aimed to investigate the effects of Tartrazine, a common industrial food dye, on kidney and whether Thymoquinone has a protective effect in tartrazine-induced nephrotoxicity. The study conducted on the rats bred at İnönü University Experimental Animals Production and Research Center. Wistar albino rats were randomly divided into 4 groups, where each group included
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Intraarticular botulinum toxin type A versus corticosteroid or hyaluronic acid for painful knee osteoarthritis: A meta-analysis of head-to-head randomized controlled trials Toxicon (IF 2.8) Pub Date : 2024-02-22 Yinan Yang, Guozheng Li, Yuping Su
Intraarticular botulinum toxin type A (BTA) has been shown to be effective for painful knee osteoarthritis (KOA), while the efficacy and safety of intraarticular BTA compared to corticosteroid and hyaluronic acid (HA) remains unknown. A meta-analysis was performed to compare. A search was conducted in Medline (PubMed), CENTER (Cochrane Library), Embase (Ovid), Web of Science, Wanfang, and CNKI to find
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Quantifying venom production: A study on Micrurus snakes in Mexico Toxicon (IF 2.8) Pub Date : 2024-02-22 Edgar Neri-Castro, Vanessa Zarzosa, Melisa Benard-Valle, Audrey Michelle Rodríguez-Solís, Lorena Hernández-Orihuela, Javier A. Ortiz- Medina, Alejandro Alagón
Our study quantifies venom production in nine Mexican coral snake species (), encompassing 76 specimens and 253 extractions. Noteworthy variations were observed, with and displaying diverse yields, ranging from 0.3 mg to 59 mg. For animals for which we have length data, there is a relationship between size and venom quantity. Twenty-eight percent of the observed variability in venom production can
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Betulinic acid attenuates T-2 toxin-induced lung injury by activating Nrf2 signaling pathway and inhibiting MAPK/NF-κB signaling pathway Toxicon (IF 2.8) Pub Date : 2024-02-21 Chunlin Huang, Zhaoping Ou, Li Kong, You Huang, Wenjiang Yang, Jiayu He, Mingqi Yang, Jing Wu, Siting Xiang, Yu Zhou, Jine Yi
T-2 toxin, a type-A trichothecene mycotoxin, exists ubiquitously in mildewed foods and feeds. Betulinic acid (BA), a pentacyclic triterpenoid derived from plants, has the effect of relieving inflammation and oxidative stress. The purpose of this study was to investigate whether BA mitigates lung impairment caused by T-2 toxin and elucidate the underlying mechanism. The results indicated that T-2 toxin
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Biopesticide Turex®‘s cytotoxicity, genotoxicity and cell cycle arrest on HepG2 cell line Toxicon (IF 2.8) Pub Date : 2024-02-20 Párástu Oskoei, Sofia Guilherme, Helena Oliveira
Population growth leads to the need for more efficient techniques and compounds in agriculture, such as pesticides, to deal with the ever-growing demand. Pesticides may end up in the environment, often compromising the ecosystem affecting all organisms including humans. Therefore, the consequences of exposure to these compounds to biota and humans needs to be assessed. Bearing this in mind, the aim
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Leucaena leucocephala toxicity in Brazilian horses Toxicon (IF 2.8) Pub Date : 2024-02-19 Mizael Machado, Cintia R.R. Queiroz-Machado, Dale R. Gardner, Márcio B. Castro, Antônio Carlos L. Câmara, Luciano A. Pimentel, Glauco J.N. Galiza, Franklin Riet-Correa
poisoning is reported in horses in different Brazilian regions. The poisoning occurred one month after the horses were introduced into paddocks invaded by the plant or after 10 days of consuming cut administered as the only food. Affected horses showed moderate to severe hair loss on the mane and tail, orthokeratotic hyperkeratosis with marked follicular telogenization, and hyperplasia of thyroid follicular
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Effects of microcystin-LR on purification efficiency of simulating drinking water source by Hydrocharis dubia (Bl.) backer Toxicon (IF 2.8) Pub Date : 2024-02-17 Junfei Liu, Yingbo Dong, Hai Lin
The safety of drinking water source directly affects human health. Microcystin-LR (MC-LR), a toxic and common pollutant in drinking water source, is released by algae and can impede the in-situ remediation effect of aquatic plant. Finding out the effect mechanism of MC-LR on the purification of drinking water by aquatic plant is the key to its application. This study aims to explore the performance
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Ruminant metabolism of zygacine, the major toxic alkaloid in foothill death camas (Zigadenuspaniculatus) Toxicon (IF 2.8) Pub Date : 2024-02-15 Stephen T. Lee, Clinton A. Stonecipher, Benedict T. Green, Kevin D. Welch, Dale R. Gardner, Daniel Cook
Death Camas ( spp.) are common poisonous plants distributed throughout North America. The toxic alkaloids in foothill death camas are zygadenine and a series of zygadenine esters, with zygacine, the 3-acetyl ester of zygadenine, being the most abundant. Both cattle and sheep can be poisoned by grazing death camas, however, sheep consume death camas more readily and are most often poisoned. We hypothesized
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The association between the neutrophil lymphocyte ratio and local edema after viper snake envenomation in South Korea Toxicon (IF 2.8) Pub Date : 2024-02-15 Jeong Mi Moon, B.J. Chun, Y.J. Koo
The role of the inflammatory process in the pathogenesis of local edema-related envenomation has not been explored with endemic venomous snakebites in Korea. species are responsible for most snakebites in South Korea. In this study we aimed to investigate whether the neutrophil–lymphocyte ratio is relevant to snake envenomation-induced local edema in South Korea. This retrospective study divided 126
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Therapeutic effects of hederacolchiside A1 on particulate matter-induced pulmonary injury Toxicon (IF 2.8) Pub Date : 2024-02-14 Sanghee Cho, Hui Ji Choi, Gyu Yong Song, Jong-Sup Bae
Particulate matter (PM) comprises a hazardous mixture of inorganic and organic particles that carry health risks. Inhaling fine PM particles with a diameter of ≤2.5 μm (PM) can promote significant lung damage. Hederacolchiside A1 (HA1) exhibits notable in vivo antitumor effects against various solid tumors. However, our understanding of its therapeutic potential for individuals with PM-induced lung
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Mechanisms involved in the cytoprotective effects of Lonomia obliqua venom on human endometrial stromal cells Toxicon (IF 2.8) Pub Date : 2024-02-09 Raquel de Almeida Schneider, Paula Barros Terraciano, Pamela Zanon, Letícia Quandt, Debora Helena Zanini Gotardi, Tuane Nerissa Alves Garcez, Lucélia Santi, Walter Orlando Beys da Silva, Ivan Sereno Montenegro, John Yates, Jorge Almeida Guimarães, Eduardo Pandolfi Passos, Markus Berger
The pathophysiology of recurrent pregnancy loss (RPL) involves deficiencies in the proliferation and migration capacities of endometrial stromal cells (hESCs), which impair embryo implantation and development. Since animal venoms are rich source of bioactive molecules, we aimed to characterize the cytoprotective effects of venom on hESCs. hESCs were isolated from endometrial biopsies and the mechanisms
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A review of poisoning with various types of biotoxins and its common clinical symptoms Toxicon (IF 2.8) Pub Date : 2024-02-08 Mohammadreza Parak, Alireza Asgari, Yazdan Hasani Nourian, Mostafa Ghanei
Biotoxins are toxic substances that originate from living organisms and are harmful to humans. Therefore, we need to know the symptoms of biotoxins poisoning to manage the damage. The purpose of this study is to establish a practical diagnostic protocol for dealing with poisoned patients exposed to biotoxins. The present study is a review study. Our studied community is articles and books matching
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Arenobufagin, isolated from Bufo viridis toad venom, inhibits A549 cells proliferation by inducing apoptosis and G2/M cell cycle arrest Toxicon (IF 2.8) Pub Date : 2024-02-07 Qiang Dong, Gulmira Turdu, Haji Akber Aisa, Abulimiti Yili
Lung cancer is a significant contributor to cancer morbidity and mortality globally. Arenobufagin, a compound derived from toad venom, has demonstrated the ability to inhibit cell growth in various cancer cell lines. However, our understanding of the role and mechanism of arenobufagin in lung cancer remains incomplete, necessitating further researches to fully elucidate its action mechanism. In this
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Dietary supplementation of Capsicum powder affects the growth, immunoglobulins, pro-inflammatory cytokines, adipokines, meat, and liver histology of aflatoxin B1 exposed broiler chickens Toxicon (IF 2.8) Pub Date : 2024-02-06 Olugbenga D. Oloruntola, Simeon O. Ayodele, Deborah A. Oloruntola, Olumuyiwa J. Olarotimi, Andrew B. Falowo, Victor O. Akinduro, Francis A. Gbore, Olufemi A. Adu, Johnson O. Agbede
The effects of dietary supplementation with fruit pericarp powder (CPP) and fruit seed powder (CSP) on the health and performance of broiler chickens exposed to aflatoxin B1 (AFB1) was investigated. Four dietary groups were established: CON (control), AFT (0.5 mg/kg AFB1), CPAF (0.5 g/kg CPP and 0.5 mg/kg AFB1), and CSAF (0.5 g/kg CSP and 0.5 mg/kg AFB1). The AFT group shows a significant (P < 0.05)
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Toxic responses of metabolites produced by Ostreopsis cf. ovata on a panel of cell types Toxicon (IF 2.8) Pub Date : 2024-02-06 Rachelle Lanceleur, Marin-Pierre Gémin, Anne-Louise Blier, Lisa Meslier, Damien Réveillon, Zouher Amzil, Eva Ternon, Olivier P. Thomas, Valérie Fessard
Blooms of the dinoflagellate cf. are regularly associated with human intoxications that are attributed to ovatoxins (OVTXs), the main toxic compounds produced by this organism and close analogs to palytoxin (PlTX). Unlike for PlTX, information on OVTXs'toxicity are scarce due to the absence of commercial standards. Extracts from two cultures of Mediterranean strains of . cf. (MCCV54 and MCCV55), two
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Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model Toxicon (IF 2.8) Pub Date : 2024-02-06 Ronald Vlasblom, Jory van Thiel, Matyas A. Bittenbinder, Jon-Ruben van Rhijn, Rinske Drost, Lotte Muis, Julien Slagboom, Daniela Salvatori, Jeroen Kool, Robert Jan Veldman
Here we describe the acute myocardial effects of an elapid (red spitting cobra, ) and a viper (western diamondback rattlesnake, ) venom using an heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with
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Ageratina adenophora causes intestinal integrity damage in goats via the activation of the MLCK/ROCK signaling pathway Toxicon (IF 2.8) Pub Date : 2024-02-06 Jianchen Wang, Shu Wang, Samuel Kumi Okyere, Juan Wen, Xiaoxuan Wang, Ruya Huang, Ziyao Tang, Suizhong Cao, Juliang Deng, Zhihua Ren, Yanchun Hu
As a global toxin invasive species, the whole herb of contains various sesquiterpenes, which can cause various degrees of toxic reactions characterized by inflammatory damage when ingested by animals. Current studies on the toxicity of have focused on parenchymatous organs such as the liver and spleen, but few studies have been conducted on the intestine as the organ that is first exposed to and digests
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Wild mushroom poisoning: A case study of amatoxin-containing mushrooms and implications for public health Toxicon (IF 2.8) Pub Date : 2024-02-03 Zhifan He, Xiaohui Li, Min Feng, Xixi Wang, Yao Wang, Jianxin Chen
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Bufalin reprograms erythrocyte lifespan through p38 MAPK and Rac1 GTPase Toxicon (IF 2.8) Pub Date : 2024-02-03 Mohammad A. Alfhili, Jawaher Alsughayyir
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Daboialipase, a phospholipase A2 from Vipera russelli russelli venom posesses anti-platelet, anti-thrombin and anti-cancer properties Toxicon (IF 2.8) Pub Date : 2024-02-02 Nivedita Kolvekar, Navodipa Bhattacharya, Sukanta Mondal, Angshuman Sarkar, Dibakar Chakrabarty
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First report of clinically significant bites due to Platyceps ventromaculatus (GRAY, 1834) from Thar Desert region, Rajasthan, India Toxicon (IF 2.8) Pub Date : 2024-02-02 Akhilesh Kumar PH, Sourish Kuttalam, Divya Tanwar, Bharat Choudhary, Mahendra Kumar Garg, Maya Gopalakrishnan
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TLC and HPLC methods for the determination of plumbagin for the diagnosis of poisoning by Plumbago scandens L Toxicon (IF 2.8) Pub Date : 2024-02-01 Carlos José Rocha Teixeira, Barbara Pereira dos Santos, Carolina Julia Costa Saraiva, Heloísa de Paula Pedroza, Silvia Catarina Salgado Oloris, Benito Soto-Blanco
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Evaluation of spontaneous exploratory and anxiety-related behaviors of mice treated with gymnopilins obtained from the mushroom Gymnopilus imperialis (Agaricomycetes, Basidiomycota) Toxicon (IF 2.8) Pub Date : 2024-01-28 Lhaís Araújo Caldas, Beatriz Gangale Muratori, Andressa Gabriela Soliani, Suzete Maria Cerutti, Patrícia Sartorelli
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Mathematical models for predicting protodioscin in tropical forage grasses Toxicon (IF 2.8) Pub Date : 2024-01-24 Juliana Caroline Santos Santana, Gelson dos Santos Difante, Jéssica Gomes Rodrigues, Marislayne de Gusmão Pereira, Henrique Jorge Fernandes, Camila Celeste Brandão Ferreira Ítavo, Vanessa Zirondi Longhini, Alexandre Menezes Dias, Luís Carlos Vinhas Ítavo
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Evaluation of acute toxicity of Scabiosa artropurperea var.maritima aqueous extracts in Swiss mice Toxicon (IF 2.8) Pub Date : 2024-01-17 Wijden Niama, Samia Ben Said, Christelle Rame, Mohamed Aroua, Mokhtar Mahouachi, Pascal Froment, Joëlle Dupont
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Synaptic Release of Pathological Tau Is Calcium- and SNAP25-Dependent, and Blocked by BoNT-A Activity Toxicon (IF 2.8) Pub Date : 2024-01-21 Anna Masato, Chiara Panzi, Ioana Butnaru, Laura Restani, Francesca Mazzo, Emanuele Sher, Suchira Bose, Giampietro Schiavo
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Botulinum Neurotoxin Type A in Multimodal Management of Postamputation Limb Pain and Related Disorders Toxicon (IF 2.8) Pub Date : 2024-01-21 Aleksandr Esipov, Aleksandr Ivolgin, Tatiana Avseitseva, Olga Orlova, Ada Artemenko, Natalia Suponeva, Andrey Mazur
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Molecular Characterization of Group I Clostridium botulinum Type A(B) (bont A1,B5) Strains in the United States Toxicon (IF 2.8) Pub Date : 2024-01-21 Lori Gladney, Ana Rafaela Kruemmel, Jessica L. Halpin, Carolina Lúquez
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Detection of a Streptogramin A O-acetyltransferase vot(D)-Like Gene in the Chromosome of Clostridium botulinum Isolated From Infants in the United States Toxicon (IF 2.8) Pub Date : 2024-01-21 Ana Rafaela Kruemmel, Jessica L. Halpin, Victoria Foltz, Janet Dykes, Carolina Lúquez
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Social Media Listening Study to Understand the Journey and Unmet Needs of Patients Living With PSS Toxicon (IF 2.8) Pub Date : 2024-01-21 Stefano Carda, Jörg Wissel, Damon Hoad, Gerard E Francisco, Monica Verduzco-Gutierrez, Daniela Gallardo, Matteo Vacchelli, Jorge Jacinto
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Duration of Botulinum Toxin Efficacy in Cervical Dystonia Clinical Trials: A Narrative Review Toxicon (IF 2.8) Pub Date : 2024-01-21 Anna Castagna, Hyder A. Jinnah, Alberto Albanese
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Botulinum Toxin and Gross Motor Function Classification System: A 15-Year Retrospective Study on Target Muscles and Doses Toxicon (IF 2.8) Pub Date : 2024-01-21 João Luís, Gonçalo Martins e Pereira, David Cordeiro, Fernanda Pinheiro, Sara Antunes, Margarida Mota Freitas, Susana Almeida
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Serendipity Identifies Two Tinnitus Subtypes That Respond to Botulinum Toxin. Are There More? Toxicon (IF 2.8) Pub Date : 2024-01-21 Robert Levine, Danièle Ranoux
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Observational Study of the Effect of a Bupivacaine Diluent in Botulinum Neurotoxin Injections to Reduce Post-Procedural Headache in Patients With Chronic Migraine Toxicon (IF 2.8) Pub Date : 2024-01-21 Madisen Janssen, David Y. Balser, Stephanie Standal
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Botulinum Neurotoxin Treatment Dynamics and Persistence Over 2 Years in Patients With Cervical Dystonia or Spasticity: A Retrospective Claims Database Analysis Toxicon (IF 2.8) Pub Date : 2024-01-21 David M. Simpson, Jonathan Bouchard, Simon Page, Dean Spurden, Seth Goldfarb, Atul T. Patel
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Combining Botulinumtoxin Type A and Specific Speech Therapy Exercises to Improve the Quality of Rehabilitation In Children With Sialorrhea Toxicon (IF 2.8) Pub Date : 2024-01-21 Diana Krasavina, Ivan Frolov, Simon Vtyurin
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Effective Multi-Disciplinary Working in the Management of the Upper Limb in Children With Cerebral Palsy: A Child- and Family Centered Holistic Approach for Clinical Decision Making With Respect to Therapy, Medical, and Surgical Interventions Toxicon (IF 2.8) Pub Date : 2024-01-21 Joanna Lloyd, Kathryn Johnson, Mobin Syed, Maxim D. Horwitz, Iram Cockar, Jill Cadwgan
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BTA Abdominal Wall Preparation for Ventral Hernia Surgery: Promising Results From a Single Academic Center Toxicon (IF 2.8) Pub Date : 2024-01-21 N. Bontekoning, M.V.H. Rutten, A.S. Timmer, C. Aehling, T.C.P.M. Kemper, M.A. Boermeester
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Evaluation of Botulinum Neurotoxin Serotype F in a Bivalent Bf Strain Isolated From an Infant Botulism Case–2018 Toxicon (IF 2.8) Pub Date : 2024-01-21 Victoria M. Foltz, Janet Dykes, Jessica Halpin, Carolina Lúquez
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Improvement in Spasticity-Associated Limb Position Abnormality in Adults Following Treatment With IncobotulinumtoxinA: A Pooled Analysis Toxicon (IF 2.8) Pub Date : 2024-01-21 Franco Molteni, Jörg Wissel, Klemens Fheodoroff, Michael C. Munin, Atul T. Patel, Michael Althaus, Georg Comes, Andrzej Dekundy, Irena Pulte, Astrid Scheschonka, Matteo Vacchelli, Andrea Santamato