样式: 排序: IF: - GO 导出 标记为已读
-
Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended‐release microparticle formulation: A phase 1, dose‐ascending study in male volunteers Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-14 Elisabeth Kjær Jensen, Søren Bøgevig, Torben Balchen, Anders Holten Springborg, Mike Allan Royal, Ida Klitzing Storgaard, Trine Meldgaard Lund, Kirsten Møller, Mads Utke Werner
A novel microparticle‐based extended‐release local anaesthetic containing a bupivacaine/poly‐lactic‐co‐glycolic acid (PLGA; LIQ865A) or plain bupivacaine (LIQ865B) was examined in a first‐in‐human trial. The objectives were to examine the dose safety/tolerability and pharmacodynamics. Randomized subcutaneous injections of LIQ865A (n = 16) or LIQ865B (n = 12) and diluent, contralaterally, were administered
-
A review on the new age methodologies for early detection of Alzheimer's and Parkinson's disease Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-14 Nabanita Ghosh, Krishnendu Sinha, Parames C. Sil
BackgroundsNeurodegenerative diseases (NDDs) such as Alzheimer's (AD) and Parkinson's (PD) are often diagnosed late, impeding effective treatment; therefore, early detection is imperative. Modern methodologies can serve a pivotal role in fulfilling the crucial need for timely detection and intervention in this context.ObjectivesEvaluate early detection's significance and summarize key technologies
-
Issue Information Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-14
No abstract is available for this article.
-
A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin‐induced hepatotoxicity in mice Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-13 Lijuan Xiong, Kexin Lin, Tianmu He, Xingyan Liu, Rui Yuan, Xiaofei Li, Jianyong Zhang
Cantharidin (CTD) is a widely used anticancer compound, but its clinical use is mainly limited due to hepatotoxicity. Ginsenoside Rb1 (GRb1) shows potential hepatoprotective effects. Nonetheless, the protective effect and underlying mechanism of GRb1 against CTD‐induced hepatotoxicity in mice have not been investigated. This study aims to elucidate the effect and mechanism of GRb1 on CTD‐induced hepatotoxicity
-
Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-13 Maria de Fátima dos Santos Sampaio, Yara Bezerra de Paiva, Tuane Bazanella Sampaio, Messias Gonzaga Pereira, Norberto Cysne Coimbra
-
Matrix metalloproteinases are associated with severity of disease among COVID‐19 patients: A possible pharmacological target Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-12 Gisele Lopes Cavalcante, Lívia Pimenta Bonifacio, Jéssica Maria Sanches‐lopes, Fernanda Guioti Puga, Felipe Santos de Carvalho, Fernando Bellissimo‐Rodrigues, Jose Eduardo Tanus‐Santos
COVID‐19 is a devastating disease and imbalanced matrix metalloproteinase (MMP) activity may contribute to its pathophysiology. This exploratory study examined whether increased circulating concentrations of MMP‐2 and MMP‐9, and their endogenous inhibitors, the tissue inhibitors of MMP (TIMP)‐1, TIMP‐2, TIMP‐3 and TIMP‐4 are persistently found in patients 2 weeks after their recovery from severe or
-
Dementia and depression: Biological connections with amyloid β protein Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-09 Helamã Moraes dos Santos, Amanda Gollo Bertollo, Maiqueli Eduarda Dama Mingoti, Roberta Eduarda Grolli, Kelli Maria Kreuz, Zuleide Maria Ignácio
-
The glucocorticoid dexamethasone alleviates allergic inflammation through a mitogen‐activated protein kinase phosphatase‐1‐dependent mechanism in mice Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-05 Tiina Lehtola, Elina Nummenmaa, Riina Nieminen, Mari Hämäläinen, Katriina Vuolteenaho, Eeva Moilanen
Glucocorticoids are widely used in the treatment of allergic and inflammatory diseases. Glucocorticoids have a widespread action on gene expression resulting in their pharmacological actions and also an array of adverse effects which limit their clinical use. It remains, however, to be studied which target gene effects are essential for the anti‐allergic activity of glucocorticoids. Mitogen‐activated
-
Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-03-01 Thamyris Santos‐Silva, Debora A. E. Colodete, João Roberto Fernandes Lisboa, Ícaro Silva Freitas, Caio Fábio Baeta Lopes, Victor Hadera, Thaís Santos Almeida Lima, Adriana Jesus Souza, Felipe V. Gomes
The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly “neuron‐centric” paradigm. Particularly, the perineuronal nets (PNNs), a specialized net‐like structure formed by ECM aggregates, play significant roles in brain development and physiology. PNNs enwrap synaptic junctions in various brain regions, precisely balancing
-
Characteristics of α1‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-27 Masaru Yoshizumi, Shin‐nosuke Ise, Akihiko Yonezawa, Chizuko Watanabe, Shinobu Sakurada, Hirokazu Mizoguchi
Although α1‐adrenoceptor (α1‐AR) antagonists used to treat benign prostatic hyperplasia can cause ejaculation disorders, the aetiology of this adverse event is still controversial. Therefore, we investigated the effects of antagonists with different affinities for α1‐AR subtypes on ejaculatory function and their mechanisms of action in normal rats. In the spontaneous seminal emission (SSE) test, systemically
-
Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-27 Jens Hohwü Voigt, Katrine M. Lauritsen, Steen Bønløkke Pedersen, Troels K. Hansen, Niels Møller, Niels Jessen, Marcello C. Laurenti, Chiara Dalla Man, Adrian Vella, Lars C. Gormsen, Esben Søndergaard
-
Pharmacogenetic testing of CYP2D6, CYP2C19 and CYP2C9 in Denmark: Agreement between publicly funded genotyping tests and the subsequent phenotype classification Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-26 Morten Baltzer Houlind, Luise Hansen, Esben Iversen, Henrik Berg Rasmussen, Jens Borggaard Larsen, Steffen Jørgensen, Kim Dalhoff, Per Damkier, Anne B. Walls, Charlotte Vermehren, Trine Rune Høgh Andersen, Thomas Kallemose, Lona Christrup, Niels Westergaard
1 INTRODUCTION The cytochrome P450 (CYP) enzyme family catalyses the metabolism of approximately 80% of all medications.1, 2 Many genes encoding the CYP enzymes exhibit high levels of polymorphism that affect their expression and activity. The most frequent and clinically important variations exist within the genes CYP2D6, CYP2C19 and CYP2C9.1 CYP2D6, the most extensively studied drug-metabolizing
-
The effects of cannabidiol against Methotrexate‐induced lung damage Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-23 Ozlem Ozmen, Adem Milletsever, Serife Tasan, Esma Selcuk, Mehtap Savran
Methotrexate (MTX) is a widely used medication for various cancers, yet its use is associated with adverse effects on organs, notably the lungs. Cannabidiol (CBD), known for its antioxidant and anti‐inflammatory properties, was investigated for its potential protective effects against MTX‐induced lung injury. Thirty‐two female Wistar Albino rats were divided into four groups: control, MTX (single 20
-
Effect of stearyl alcohol on imiquimod-induced psoriasis-like skin inflammation in mice Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-20 Yu-Hang Dai, Fang-Li Sun, Rui-Miao Wei, Jia-Ji Guo, De-Li Dong, Zhi-Jie Sun
Psoriasis is a chronic inflammatory skin disease. Topical medicines are the preferred treatment for mild to moderate psoriasis, but the effect of excipients used in semi-solid preparations on psoriasis-like skin inflammation is not fully understood. In the present study, we investigated the effect of stearyl alcohol, a commonly used excipient, on imiquimod (IMQ)-induced psoriasis-like skin inflammation
-
Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-20 Taija Voutilainen, Leea Keski-Nisula, Jaana Rysä, Olli Kärkkäinen
Smoking during pregnancy is one of the leading causes for adverse pregnancy outcomes. We studied parental smoking both before and during pregnancy in a retrospective cohort of 21 472 singleton pregnancies. Although most smoking women (74%) ceased tobacco use, there was possible gestational exposure to maternal cigarette smoking in every fifth pregnancy. Continued smoking throughout pregnancy was more
-
Ehrlich ascites carcinoma provokes renal toxicity and DNA injury in mice: Therapeutic impact of chitosan and maitake nanoparticles Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-18 Hamed A. Abosharaf, Doaa T. Gebreel, Sahar Allam, Afaf El-Atrash, Ehab Tousson
In this study, the impact of chitosan (CS) and maitake (GF) nanoparticles towards the renal toxicity induced by Ehrlich ascites carcinoma (EAC) in vivo model was conducted. Besides benchmark negative control group, EAC model was constructed by intraperitoneal injection (i.p.) of 2.5 × 106 cells. Alongside positive control, two groups of EAC-bearing mice received 100 mg/kg of CS and GF nanoparticles/body
-
Issue Information Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-11
No abstract is available for this article.
-
Inappropriate prescribing in patients with kidney disease: A rapid review of prevalence, associated clinical outcomes and impact of interventions Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-13 Zohra Hamzaei, Morten Baltzer Houlind, Lene Juel Kjeldsen, Louise Westberg Strejby Christensen, Anne Byriel Walls, Anissa Aharaz, Charlotte Olesen, Faruk Coric, Joo Hanne Poulsen Revell, Lene Vestergaard Ravn-Nielsen, Trine Rune Høgh Andersen, Ulla Hedegaard
The prevalence of patients with chronic kidney disease (CKD) and polypharmacy is increasing and has amplified the importance of examining inappropriate prescribing (IP) in CKD. This review focuses on the latest research regarding the prevalence of IP in CKD and the related adverse clinical effects and explores new interventions against IP.
-
Effect on QTc interval by switching from methadone to equipotent R-methadone dose in methadone maintenance treatment patients Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-03 Stine Marie Havig, Riikka Mari Berg-Pedersen, Hege-Merete Krabseth, Lill Dannevig Müller, Kristina Haugaa, Hasse Khiabani Zare, Knut Gjesdal, Peter Krajci, Mimi Stokke Opdal
Methadone (R,S-methadone) can prolong the QT interval. R-methadone inhibits cardiac potassium channel function less than S-methadone. We tested if switching from methadone to R-methadone would reduce corrected QT (QTc) intervals in methadone maintenance treatment (MMT) patients. Nine patients, with automatically read QTc intervals ≥450 ms, were required to detect a 20 ms (clinically relevant) reduction
-
Use of drugs with pharmacogenomics (PGx)-based dosing guidelines in a Danish cohort of persons with chronic kidney disease, both on dialysis and not on dialysis: Perspectives for prescribing optimization Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-02-03 Niels Westergaard, Morten Baltzer Houlind, Lona Louring Christrup, Helle Gybel Juul-Larsen, Charlotte Strandhave, Anne Estrup Olesen
The objective of this registry study is to assess the utilization of pharmacogenomic (PGx) drugs among patients with chronic kidney disease (CKD).
-
Exploring the role of oxidative stress and the effect of N-acetylcysteine in thiopurine-induced liver injury in inflammatory bowel disease: A randomized crossover pilot study Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-01-29 Dirk P. van Asseldonk, Femke Crouwel, Margien L. Seinen, Peter G. Scheffer, Agnes I. Veldkamp, Nanne K. de Boer, Birgit Lissenberg-Witte, Godefridus J. Peters, Adriaan A. van Bodegraven
Thiopurine treatment is regularly complicated by drug-induced liver injury. It has been suggested that oxidative stress may play a synergistic role. To assess whether thiopurine-induced liver injury coincides with increased oxidative stress and whether co-administration with N-acetylcysteine is protective, we performed a randomized open label crossover pilot study in inflammatory bowel disease patients
-
Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-01-29 Mackenzie Newman, Cayla Lynch, Heather Connery, William Goldsmith, Timothy Nurkiewicz, Raymond Raylman, Jonathan Boyd
Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up-down procedure, with subjects monitored post-administration using pulse oximetry (5 min) and then whole-body plethysmography (40 min). Following the determination
-
Review of clinical pharmacokinetics and pharmacodynamics of clonidine as an adjunct to opioids in palliative care Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-01-26 Sarwat Amna, Thomas Øhlenschlæger, Eva Aggerholm Sædder, Jarl Voss Sigaard, Troels Korshøj Bergmann
Clonidine is an α-adrenoceptor agonist acting on receptors in the brain and peripheral tissues, leading to a reduction in sympathetic outflow and release of certain neurotransmitters. Clonidine has multiple uses across various medical conditions. One of its uses is as adjuvant to anaesthetic and analgesic agents specially opioids, mostly administered through intravenous and epidural routes. The opioids
-
Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-01-26 Silje Skrede, Nataša Bogavac-Stanojević, Erwin Dreesen, Elisabet Nielsen, Martina Zaninotto, Denis Mulleman
The European Cooperation in Science and Technology (COST) action ENOTTA (The European Network on Optimising Treatment with Therapeutic Antibodies in chronic inflammatory diseases) was launched in 2022. To pave the way for harmonization of analytical methods for quantitation of serum levels of therapeutic antibodies in research and clinical settings, ENOTTA recently performed an online survey mapping
-
The role of ATP-binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A review of the mechanisms Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-01-26 Mohsen Karbasi Yazdi, Mohaddeseh Sadat Alavi, Ali Roohbakhsh
The maintenance of cholesterol homeostasis is essential for central nervous system function. Consequently, factors that affect cholesterol homeostasis are linked to neurological disorders and pathologies. Among them, ATP-binding cassette transporter G1 (ABCG1) plays a significant role in atherosclerosis. However, its role in Alzheimer's disease (AD) is unclear. There is inconsistent information regarding
-
Advances in noninvasive measurement of liver function and physiology: The HepQuant DuO test Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-01-15 Michael P. McRae, John Kittelson, Steve M. Helmke, Gregory T. Everson
Current noninvasive liver tests are surrogates for fibrosis and lack ability to directly measure liver function. HepQuant tests measure liver function and physiology through hepatic uptake of stable cholate isotopes. HepQuant SHUNT (V1.0) involves oral and intravenous dosing and six blood samples over 90 min. We developed simplified test versions: SHUNT V2.0 (oral and intravenous dosing, two blood
-
Issue Information Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2024-01-11
No abstract is available for this article.
-
Therapeutic benefit of melatonin in 5-fluorouracil-induced renal and hepatic injury Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-12-21 Razieh Mansoori, Sohrab Kazemi, Darya Almasi, Seyed Mohammad Hosseini, Bardia Karim, Majid Nabipour, Ali Akbar Moghadamnia
-
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-12-20 Fatemeh Chalabianloo, Lars Thore Fadnes, Kjell Arne Johansson, Gudrun Høiseth, Jørn Henrik Vold, Marianne K. Kringen, Olav Spigset, Jørgen G. Bramness
A considerable inter-individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. However, the underlying causes for this variability are not fully understood.
-
Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-12-18 Yingya Wang, Natalja Genina, Anette Müllertz, Jukka Rantanen
Current treatment strategies are moving towards patient-centricity, which emphasizes the need for new solutions allowing for medication tailored to a patient. This can be realized by precision medicine where patient diversity is considered during treatment. However, the broader use of precision medicine is restricted by the current technological solutions and rigid manufacturing of pharmaceutical products
-
A study of the genotoxicity, fertility and early embryonic development toxicity of rotigotine behenate extended-release microspheres Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-12-17 Xinyu Zhao, Chunmin Guo, Hong Zhang, Xin Yu, Guagnying Du, Jingwei Tian, Wanhui Liu, Tao Song, Xiaobo Chen, Wei Guo
Continuous dopaminergic stimulation (CDS) has become an important strategy for the development of drugs to treat Parkinson's disease (PD). Rotigotine behenate extended-release microspheres (RBEM) for injection represent a new treatment regime for CDS and are undergoing clinical trials. In this study, we aimed to investigate the effect of RBEM on genotoxicity, fertility and early embryonic development
-
Effect of albumin infusion on oxidative albumin modification and albumin binding capacity in chronic liver failure Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-12-13 Rudolf E. Stauber, Margret Paar, Irina Balazs, Angela Horvath, Nicole Feldbacher, Andreas Posch, Florian Rainer, Vanessa Stadlbauer, Karl Oettl
Oxidative albumin modification and impaired albumin binding function have been described both in chronic liver failure and for therapeutic albumin solutions. The aim of the present study was to evaluate the effect of albumin infusion on redox state and binding function of circulating albumin. We studied 20 patients with cirrhosis who routinely received albumin infusions for prevention of post-paracentesis
-
The role of peroxisome proliferator-activated receptors in the regulation of bile acid metabolism Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-12-04 Yuqing Sun, Luyong Zhang, Zhenzhou Jiang
Bile acids are synthesized from cholesterol in the liver. Dysregulation of bile acid homeostasis, characterized by excessive accumulation in the liver, gallbladder and blood, can lead to hepatocellular damage and the development of cholestatic liver disease. Nuclear receptors play a crucial role in the control of bile acid metabolism by efficiently regulating bile acid synthesis and transport in the
-
The gender composition of the members of the editorial board of toxicology journals: Assessment of gender equality Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-29 Volkan Hancı, Mehmet Nuri Yakar, Nurgazy Shermatov, Fevzi Kara, Emel İbişoğlu, Merve Oltulu, Rıza Kaan Köşker, Duygu Bilge, Batuhan Geylani
In many areas of medicine, gender equality has not yet been fully adopted despite recent developments. The inequality of gender in various areas of medicine is still debated. In this study, we analysed the gender composition of the editorial boards of toxicology journals in the Science Citation Index-Expanded (SCI-E) databases and the factors affecting this composition.
-
Bromodomain-containing protein 4 inhibition improves the efficacy of cisplatin and radiotherapy in oral squamous cell carcinoma by suppressing programmed cell death-ligand 1 expression Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-28 Jiajie Ren
The bromodomain-containing protein 4 (BRD4) is highly expressed in oral squamous cell carcinoma (OSCC) and plays a crucial role in tumour progression. However, the impact of BRD4 on the efficacy of chemotherapy and radiotherapy by regulating the expression of programmed cell death-ligand 1 (PD-L1) in OSCC remains unclear. In this study, we found that the BRD4 inhibitor JQ1 effectively enhanced the
-
Preparation of betaine injection and its therapeutic effect in pulmonary arterial hypertension Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-27 Youlan Che, Tian Xia, Hui Liu, Cong Li, Siyun Liu, Ping Ma, Qingbin Xu, Ru Zhou
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterised by elevated pulmonary pressure, right ventricular failure (RVF) and ultimately death. Aggressive treatment of RVF is considered an important therapeutic strategy to treat PAH. Previous studies have indicated that betaine may be may a promising therapeutic approach for PAH-induced RVF. Therefore, in this study, betaine
-
Role of bradykinin and prostaglandin EP4 receptors in regulating TRPV1 channel sensitization in rat dorsal root ganglion neurons Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-27 Sara A. Aldossary, Mohammad Alsalem, Blair D. Grubb
Transient receptor potential vanilloid type-1 (TRPV1) channels play key roles in chronic pain conditions and are modulated by different inflammatory mediators to elicit heat sensitisation. Bradykinin is a 9-amino acid peptide chain that promotes inflammation. The aim of present study is to investigate how bradykinin and prostaglandin receptors (EP3 and EP4) modulate the sensitisation of TRPV1-mediated
-
Issue Information Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-20
No abstract is available for this article.
-
Relationship between prolonged gestation and nifedipine pharmacokinetics in long-term tocolysis Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-21 Miho Tamura, Susumu Murata, Chihiro Ota, Shoko Tanaka, Hitomi Arichika, Daiki Hakuno, Naoto Okada, Kentaro Ushijima, Yasuhiro Tsuji, Takashi Kitahara
In this study, we examined the pharmacokinetics of nifedipine and investigated the maternal and foetal background factors that prolong pregnancy in pregnant women undergoing long-term tocolysis. This prospective observational study included 38 pregnant women hospitalised for threatened preterm labour and treated with nifedipine extended-release tablets in combination with an intravenous ritodrine infusion
-
Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-21 Felix P. Mayer, Adele Stewart, Randy D. Blakely
Aberrant dopamine (DA) signalling has been implicated in various neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), schizophrenia, bipolar disorder (BPD) and addiction. The availability of extracellular DA is sculpted by the exocytotic release of vesicular DA and subsequent transporter-mediated clearance, rendering the presynaptic
-
Advancing deprescribing: Learnings from the first international conference on deprescribing Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-20 Carina Lundby, Wade Thompson
CONFLICT OF INTEREST STATEMENT There are no conflicts to declare.
-
Self-perceived learning outcomes of virtual and in-person academic detailing among general practitioners in Norway Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-10 Jan Schjøtt, Ingrid Lunde Steen, Ketil Arne Espnes, Bettina Riedel
Self-perceived learning outcomes of virtual academic detailing (AD) are poorly studied. We compared self-perceived learning outcomes of virtual and in-person AD among general practitioners (GPs). GPs from the Western region of Norway received a questionnaire before and after AD concerning rational pharmacotherapy of migraine in the autumn 2022. Five statements addressing specific knowledge and two
-
Transmembrane transporter proteins: Capturing transport in motion. Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-09 Claus J Loland,Petrine Wellendorph,Stine F Pedersen,Ulrik Gether
-
Kernel extreme learning with harmonized bat algorithm for prediction of pyrene toxicity in rats Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-11-09 Hang Su, Dong Zhao, Ali Asghar Heidari, Zhennao Cai, Huiling Chen, Jiayin Zhu
Polycyclic aromatic hydrocarbons (PAHs) are organic pollutants and manufactured substances conferring toxicity to human health. The present study investigated whether pyrene, a type of PAH, harms rats. Our research provides an effective feature selection strategy for the animal dataset from Wenzhou Medical University's Experimental Animal Center to thoroughly examine the impacts of PAH toxicity on
-
Trends in medication use at the onset of and during the COVID-19 pandemic in the Republic of Ireland: An interrupted time series study Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-30 Molly Mattsson, Jung Ah Hong, John Scott Frazer, Glenn Ross Frazer, Frank Moriarty
The COVID-19 pandemic had a substantial impact on healthcare delivery, particularly in general practice. This study aimed to evaluate how dispensing of medications in primary care in Ireland changed following the COVID-19 pandemic's onset compared to expected trends. This interrupted time series study used data on medications prescribed in general practice 2016–2022 to patient eligible for state health
-
Epidemiological surveillance of drug safety using cumulative sequential analysis in electronic healthcare data Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-27 Mia Aakjær, Marie Louise De Bruin, Morten Andersen
Methods for safety signal detection in electronic healthcare data analysing data sequentially are being developed to meet the limitations of spontaneous reporting systems.
-
Issue Information Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-23
No abstract is available for this article.
-
Effect of CYP2D6 genotype on duloxetine serum concentration Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-20 Kristine Hole, Sofie Gangsø, Åsa Tonette Jensstuen, Hanne Holte Ormøy, Maren Paulsen, Espen Molden, Tore Haslemo
Duloxetine is metabolized by cytochrome P450 (CYP)1A2 and CYP2D6. The aim of this study was to investigate the effect of the CYP2D6 genotype on duloxetine serum concentration adjusting for age and sex. Patients were included retrospectively from a therapeutic drug monitoring service. Multiple linear regression analysis was used to investigate the effect of CYP2D6 genotype, age and sex on the duloxetine
-
Direct oral anticoagulant concentrations and adherence in stroke patients Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-16 Rachel Aakerøy, Mari Nordbø Gynnild, Lena Løfblad, Roar Dyrkorn, Hanne Ellekjær, Stian Lydersen, Arne Helland, Olav Spigset
No therapeutic ranges linking drug concentrations of apixaban and rivaroxaban to clinical outcomes have been defined. We investigated whether direct oral anticoagulant (DOAC) concentrations among patients admitted to hospital with symptoms of stroke differed between those later verified to suffer an ischaemic cerebrovascular event (stroke or transient ischaemic attack) and those having other diagnoses
-
Attitudes towards deprescribing in geriatric psychiatry: A survey among older psychiatric outpatients Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-12 Carina Lundby, Marianne Nielsen, Trine Simonsen, Stine Galsgaard, Maija Bruun Haastrup, Lene Vestergaard Ravn-Nielsen, Anton Pottegård
Understanding the patient perspective is a significant part of the deprescribing process. This study aimed to explore the attitudes of older patients with psychiatric disorders towards deprescribing. A total of 72 of psychiatric outpatients (68% women; median age 76 years) completed the validated Danish version of the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire. Patients
-
Drug-related deaths in a university hospital: Comparison to previous decades Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-12 Mirjam Kauppila, Janne T. Backman, Mikko Niemi, Outi Lapatto-Reiniluoto
The incidence of fatal adverse drug reactions (ADRs) in hospitals varies widely, and ADRs are often underreported. The impact of medical safety processes is not easily evaluated, and although medical practice changes constantly, little is known about ADR trends. This study concentrated on the current incidence and properties of fatal ADRs occurring in a university hospital and compared the results
-
Making it happen: Development of an interprofessional deprescribing education programme Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-11 Natalie Kennie-Kaulbach, Emma Ramsay, Hannah Gormley, Jennifer E. Isenor
Deprescribing is the planned and supervised reduction or discontinuation of medications that may be causing harm or are no longer benefiting a patient. The need for deprescribing to be a routine part of patient care is essential with an aging population and the rising prevalence of polypharmacy, which has been associated with increased adverse outcomes such as falls, hospitalizations and mortality
-
Per- and polyfluoroalkyl substances and cardiometabolic diseases: A review Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-10 Tessa Schillemans, Carolina Donat-Vargas, Agneta Åkesson
Per- and polyfluoroalkyl substances (PFAS) are a group of persistent and widespread environmental pollutants that represent a high concern for human health. They have been shown to be associated with several important physiological processes such as lipid metabolism and the immune system. Consequently, PFAS are suspected to play a role in cardiometabolic disease development. However, the evidence regarding
-
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-09 Hedvig Nordeng, Christine Wegler, Annika Lindqvist, Erik Melander, Mikaela Magnusson, Peggy Gandia, Alice Panchaud, Pawel Baranczewski, Olav Spigset
Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least 8 weeks postpartum and using cetirizine or its pure (R)-enantiomer levocetirizine were eligible to participate. Breast milk samples were collected at six predefined times during a dose
-
Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-09 Enxue Tan, Zhihong Gao, Qian Wang, Baosheng Han, Honghong Shi, Lihua Wang, Guozhen Zhu, Yanjuan Hou
Berberine acts via multiple pathways to alleviate fibrosis in various tissues and shows renoprotective effects. However, its role and underlying mechanisms in renal fibrosis remain unclear. Herein, we aimed to investigate the protective effects and molecular mechanisms of berberine against unilateral ureteric obstruction-induced renal fibrosis. The results indicated that berberine treatment (50 mg/kg/day)
-
Issue Information Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-03
No abstract is available for this article.
-
Charting a new course: A vision for the future as editors-in-chief. Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-10-01 Ulf Simonsen,Jens Lykkesfeldt
-
BCPT 2023 policy for experimental and clinical studies Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-09-21 Pernille Tveden-Nyborg, Troels K. Bergmann, Niels Jessen, Ulf Simonsen, Jens Lykkesfeldt
Inconsistencies in the reproducibility of research findings are of pertinent concern throughout the scientific community. The disclosure of an apparent and low degree of reproducibility has fuelled investigations of causal factors, ranging from behavioural preferences in decision-making/‘human nature’and conviction bias to experimental constituents.1 The increased awareness has identified several aspects
-
Cerebral microbleeds in the poisoned patient: An observational magnetic resonance imaging study Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-09-21 Giulia Naïm, Isabelle Malissin, Bruno Mégarbane
Critical illness-associated cerebral microbleeds of poorly understood pathophysiology have been observed on magnetic resonance imaging (MRI) in severely hypoxaemic patients similarly to high-altitude cerebral oedema patients. The prevalence and circumstances of occurrence of such cerebral microbleeds in the severely poisoned patients are unknown. We retrospectively reviewed all cerebral MRIs performed
-
Probiotic bacteria alleviate chlorpyrifos-induced rat testicular and renal toxicity: A possible mechanism based on antioxidant and anti-inflammatory activity Basic Clin. Pharmacol. Toxicol. (IF 3.1) Pub Date : 2023-09-21 Roghayeh Nejati, Amene Nematollahi, Hashmieh Kabi Doraghi, Mehran Sayadi, Hiva Alipanah
Chlorpyrifos (CPF) has caused many potential toxicities in nontarget organisms. Fewer studies have been conducted on the effects of lactic acid bacteria (LAB) in mitigating tissue damage induced by CPF in vivo. Therefore, we investigated CPF renal and testicular toxicity and the alleviating effect of probiotic lactobacilli, based on antioxidant and anti-inflammatory activity, on induced toxicity in