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Red blood membrane camouflaging Bismuth nanoflowers designed for radio-photothermal therapy in lung cancer J. Drug Target. (IF 4.5) Pub Date : 2024-03-12 Chang Liu, Yuanyuan Zhang, Jing Wen, Ji Liu, Meirong Huo, Yan Shen, Hao Luo, Hui Zhang
Radio-photothermal therapy is an effective modality for cancer treatment. To overcome the radio-resistance in the hypoxic microenvironment and improve the sensitivity of radiotherapy, metal nanopar...
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Novel pH-Responsive Alginate-Stabilized Curcumin-Selenium-ZIF-8 Nanocomposites for Synergistic Breast Cancer Therapy J. Drug Target. (IF 4.5) Pub Date : 2024-03-06 Emma Frouhar, Arghavan adibifar, Maryam Salimi, Zahra Karami, Nasim Shadmani, Kobra Rostamizadeh
In this study, a novel selenium@Zeolitic imidazolate framework core/shell nanocomposite stabilized with alginate was used to improve the anti-tumor activity of curcumin. The developed alginate-stab...
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Enhancing Periodontal Defences with Nanofiber Treatment: Recent Advances and Future Prospects J. Drug Target. (IF 4.5) Pub Date : 2024-02-26 Unnati Garg, Tanya Dua, Shreya Kaul, Neha Jain, Manisha Pandey, Upendra Nagaich
The term periodontal disease is used to define diseases characterized by inflammation and regeneration of the gums, cementum, supporting bone, and periodontal ligament. The conventional treatment i...
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Lauric Acid-Based Thermosensitive Delivery System for the Treatment of Head and Neck Squamous Cell Carcinoma J. Drug Target. (IF 4.5) Pub Date : 2024-02-22 Maha AliAlghamdi, Mohamed Haider, Sebastiano Intagliata, Valeria Pittalà, Jayalakshmi Jagal, Youssef Haider, Nasneen Althaf, Khaled Greish
Traditional treatments for head and neck squamous cell carcinoma (HNSCC) such as surgery, radiation therapy, and chemotherapy, often have severe side effects. Local delivery of chemotherapeutic age...
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Emerging role of ferroptosis in diabetic retinopathy: a review J. Drug Target. (IF 4.5) Pub Date : 2024-02-22 Ruohong Wang, Suyun Rao, Zheng Zhong, Ke Xiao, Xuhui Chen, Xufang Sun
Diabetic retinopathy (DR) is a significant complication of diabetes and the primary cause of blindness among working age adults globally. The development of DR is accompanied by oxidative stress, c...
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In vivo evaluation of monoclonal antibody M4M using a humanised rat model of stroke demonstrates attenuation of reperfusion injury via blocking human TRPM4 channel J. Drug Target. (IF 4.5) Pub Date : 2024-02-12 Charlene Priscilla Poore, Shunhui Wei, Bo Chen, See Wee Low, Jeslyn Si Qi Tan, Andy Thiam-Huat Lee, Bernd Nilius, Ping Liao
Blocking Transient Receptor Potential Melastatin 4 (TRPM4) in rodents by our antibody M4P has shown to attenuate cerebral ischaemia-reperfusion injury. Since M4P does not interact with human TRPM4,...
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Nanoparticles toxicity: An overview of its mechanism and plausible mitigation strategies J. Drug Target. (IF 4.5) Pub Date : 2024-02-08 Nitin Sharma, Balak Das Kurmi, Dilpreet Singh, Sidharth Mehan, Kushagra Khanna, Ritu Karwasra, Shobhit Kumar, Amit Chaudhary, Vikash Jhakmola, Anjana Sharma, Sachin Kumar Singh, Kamal Dua, Dipti Kakkar
Over the last decade, nanoparticles have found great interest among scientists and researchers working in various fields within the realm of biomedicine including drug delivery, gene delivery, diag...
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Nanomedicine targeted anti-inflammatory therapy to deal with the “crux” of rheumatoid arthritis J. Drug Target. (IF 4.5) Pub Date : 2024-02-07 Min An, Juntao Zhang, Xiaojie Zhang, Yumeng Zhao, Yanhua Liu
Rheumatoid arthritis is a chronic and complex autoimmune disease that is marked by an inflammatory response, synovial hyperplasia, vascularization, fascial formation, cartilage and bone destruction...
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Plant-based Natural Products in Cancer Therapeutics J. Drug Target. (IF 4.5) Pub Date : 2024-02-05 Rohini Mahato, Dillip kumar Behera, Biswajit Patra, Shradhanjali Das, Kulwant Lakra, Surya Narayan Pradhan, Sk Jahir Abbas, Sk Imran Ali
Various cells in our body regularly divide to replace old cells and dead cells. For a living cell to be growing, cell division and differentiation is highly essential. Cancer is characterized by un...
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Insight into modulators of sphingosine-1-phosphate receptor and implications for cardiovascular therapeutics J. Drug Target. (IF 4.5) Pub Date : 2024-02-06 Yu-Xin Xie, Hui Yao, Jin-Fu Peng, Dan Ni, Wan-Ting Liu, Chao-Quan Li, Guang-Hui Yi
Cardiovascular disease is the leading cause of death worldwide, and it’s of great importance to understand its underlying mechanisms and find new treatments. Sphingosine 1-phosphate (S1P) is an act...
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Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model J. Drug Target. (IF 4.5) Pub Date : 2024-02-05 Rongsha Chen, Ke Li, Yinying Wang, Liyun Song, Ruohua Wang, Wenhui Fan, Ninghui Zhao, Wei Zou, Zhongshan Yang, Jinyuan Yan
Parkinson's disease (PD) is a central nervous system disease with the highest disability and mortality rate worldwide, and it is caused by a variety of factors. The most common medications for PD h...
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Advances in herbal polysaccharides-based nano-drug delivery systems for cancer immunotherapy J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Miao-miao Han, Yi-Kai Fan, Yun Zhang, Zheng-qi Dong
The boom in cancer immunotherapy has provided many patients with a better chance of survival, but opportunities often come with challenges. Single immunotherapy is not good enough to eradicate tumo...
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Artificial intelligence for skin permeability prediction: deep learning J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Kevin Ita, Sahba Roshanaei
Researchers have put in significant laboratory time and effort in measuring the permeability coefficient (Kp) of xenobiotics. To develop alternative approaches to this labour-intensive procedure, p...
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Nano-medicine therapy reprogramming metabolic network of tumour microenvironment: new opportunity for cancer therapies J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Xiaojie Zhang, Min An, Juntao Zhang, Yumeng Zhao, Yanhua Liu
Metabolic heterogeneity is one of the characteristics of tumour cells. In order to adapt to the tumour microenvironment of hypoxia, acidity and nutritional deficiency, tumour cells have undergone e...
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Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro, and in vivo evaluation J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Xuewei Cui, Zhong He, Jianjia Liang, Mulan Wei, Zhiyong Guo, Yiqing Zhou, Ye Qin, Zhangshuang Deng
Dehydrocurvularin (DCV) is a promising lead compound for anti-cancer therapy. Unfortunately, the development of DCV-based drugs has been hampered by its poor solubility and bioavailability. Herein,...
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Harnessing the synergistic potential of NK1R antagonists and selective COX-2 inhibitors for simultaneous targeting of TNBC cells and cancer stem cells J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Madhu Tanya Singh, Praveen Thaggikuppe Krishnamurthy, Sai Varshini Magham
Triple-negative breast cancer (TNBC) lacks the expression of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), rendering it unresponsive to e...
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Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Xian-long Fang, Xue-ping Cao, Jun Xiao, Yun Hu, Mian Chen, Hafiz Khuram Raza, Huai-yuan Wang, Xu He, Jin-fa Gu, Kang-jian Zhang
Survivin holds significant importance as a member of the inhibitor of apoptosis protein (IAP) family due to its predominant expression in tumours rather than normal terminally differentiated adult ...
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Therapeutic and diagnostic applications of carbon nanotubes in cancer: recent advances and challenges J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Muskan Sharma, Parodi Alessandro, Sanith Cheriyamundath, Manu Lopus
Carbon nanotubes (CNTs) are allotropes of carbon, composed of carbon atoms forming a tube-like structure. Their high surface area, chemical stability, and rich electronic polyaromatic structure fac...
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Elements in trace amount with a significant role in human physiology: a tumor pathophysiological and diagnostic aspects J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Manish Dwivedi, Divya Jindal, Sandra Jose, Saba Hasan, Pradeep Nayak
Cancer has a devastating impact globally regardless of gender, age, and community, which continues its severity to the population due to the lack of efficient strategy for the cancer diagnosis and ...
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Current targeting strategies and advanced nanoplatforms for atherosclerosis therapy J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Yingchao Li, Qixiang Feng, Luyue Wang, Xi Gao, Yanwei Xi, Lei Ye, Jianbo Ji, Xiaoye Yang, Guangxi Zhai
Atherosclerosis is one of the major causes of death worldwide, and it is closely related to many cardiovascular diseases, such as stroke, myocardial infraction and angina. Although traditional surg...
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Factors of faecal microbiota transplantation applied to cancer management J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Yi-Huang Liu, Juan Chen, Xiang Chen, Hong Liu
The homeostasis of the microbiota is essential for human health. In particular, the gut microbiota plays a critical role in the regulation of the immune system. Thus, faecal microbiota transplantat...
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Development and characterization of a novel neutralizing scFv vectored immunoprophylaxis against botulinum toxin type A J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Yongpeng Wei, Guangyao Li, Zhuo Wang, Kewen Qian, Shuyi Zhang, Lingling Zhang, Changhai Lei, Shi Hu
Botulinum toxin is a protein toxin secreted by Clostridium botulinum that is strongly neurotoxic. Due to its characteristics of being super toxic, quick acting, and difficult to prevent, the curren...
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Pharmaceutical cocrystals: a rising star in drug delivery applications J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Prabhakar Panzade, Anita Wagh, Pratiksha Harale, Sumeet Bhilwade
Pharmaceutical cocrystals, owing to their manifold applications, are acting as bridge between drug discovery and pharmaceutical product development. The ability to scale up pharmaceutical cocrystal...
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The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Daysiane de Oliveira, Gabriel Paulino Luiz, Rahisa Scussel, Mirian Ivens Fagundes, Nathália Coral Galvani, Jessica da Silva Abel, Rubya Pereira Zaccaron, Gustavo de Bem Silveira, Thiago Antônio Moretti de Andrade, Paulo Cesar Lock Silveira, Ricardo Andrez Machado-de-Ávila
Introduction: The search for fast and efficient treatment for dermonecrotic lesions caused by the venom of the spider from the Loxosceles simillis, is a demand in health. Prednisolone is one of the...
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Molecular mechanism of Wilms tumour 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1 J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Chen Guo, Mingyi Yu, Jinghua Liu, Zhe Jia, Hui Liu, Shaozhen Zhao
Background: Dry eye disease (DED) is often secondary to diabetes mellitus (DM).Purpose: This study is to explore the action of Wilms tumor 1-associated protein (WTAP) in DM-DED via lncRNA NEAT1 m6A...
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Colon-targeted delivery of niclosamide from solid dispersion employing a pH-dependent polymer via hotmelt extrusion for the treatment of ulcerative colitis in mice J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Sakshi Arjun, Uttam Kulhari, Amruta Prabhakar Padakanti, Bidya Dhar Sahu, Naveen Chella
Niclosamide (NCL) is repurposed to treat inflammatory bowel disease due to its anti-inflammatory properties and potential to reduce oxidative stress. This therapeutic activity remains challenging i...
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A cisplatin and disulphiram co-loaded inclusion complex overcomes drug resistance by inhibiting cancer cell stemness in non-small cell lung cancer J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Wenhui Ye, Huaiyou Lv, Qinxiu Zhang, Jianxiong Zhao, Xin Zhao, Guozhi Zhao, Chongzheng Yan, Fengqin Sun, Zhongxi Zhao, Xiumei Jia
Introduction: Non-small cell lung cancer (NSCLC) accounting for about 80-85% of all lung cancer cases is one of the fastest-growing malignancies in terms of incidence and mortality worldwide and is...
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Ghrelin inhibits myocardial pyroptosis in diabetic cardiomyopathy by regulating ERS and NLRP3 inflammasome crosstalk through the PI3K/AKT pathway J. Drug Target. (IF 4.5) Pub Date : 2024-02-01 Fan Wang, Jingzhi Wang, Xinfang Liang, Zixuan Wu, Jiaxin Xue, Lingyu Yin, Lai Wei, Xiaohui Zhang
Endoplasmic reticulum stress(ERS) can induce inflammation mediated by NLRP3 inflammatory bodies and link inflammation with oxidative stress in myocardial tissue. Ghrelin is an endogenous growth hor...
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Resveratrol-loaded Microemulsion Based Thermosensitive Hydrogel for Potential Topical Treatment of the Vaginal Inflammation J. Drug Target. (IF 4.5) Pub Date : 2024-01-30 Jiaxin Liu, Liuqi Zhou, Huijing Cong, Jing Hu, Jingling Tang
Vaginal inflammation is a prevalent gynecological condition. If left untreated, it can potentially spread to the urinary and reproductive systems. In this study, we propose a resveratrol-loaded mic...
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State-of-the-art drug delivery system to target the lymphatics J. Drug Target. (IF 4.5) Pub Date : 2024-01-22 Omkar T. Khaire, Akshada Mhaske, Aprameya Ganesh Prasad, Waleed H. Almalki, Nidhi Srivastava, Prashant Kesharwani, Rahul Shukla
The lymphatic system assumes a pivotal role in maintaining humoral equilibrium, regulating lipid metabolism, and orchestrating immune responses. Lymph nodes (LNs) are recognized as primary loci for...
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Identifying factors controlling cellular uptake of gold nanoparticles by machine learning J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Eyup Bilgi, David A. Winkler, Ceyda Oksel Karakus
There is strong interest to improve the therapeutic potential of gold nanoparticles (GNPs) while ensuring their safe development. The utility of GNPs in medicine requires a molecular-level understa...
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Enhanced neuroprotective activity of ophthalmic delivered nerve growth factor conjugated with cell penetrating peptide against optic nerve injury J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Danni Zhu, Yao Li, Jinlong Zhang, Yi Chen, Xiaohong Song, Wei Chen, Shipo Wu, Lihua Hou
Aims: Nerve growth factor is a well characterised neurotrophic factor that play a critical role in the survival, growth and differentiation of neurons both in central and peripheral nervous system....
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A paradigm use of monoclonal antibodies-conjugated nanoparticles in breast cancer treatment: current status and potential approaches J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Anmar Al-Taie, Ece Özcan Bülbül
Monoclonal antibodies (mAbs) are integral to cancer treatment over conventional non-specific therapy methods. This study provides a scoping review of the clinically approved mAbs, focusing on the c...
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Cancer stem cell biomarkers and related signalling pathways J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Zhe Wang, Rui Li, Guilin Yang, Yijin Wang
Cancer stem cells (CSCs) represent a distinct subset of neoplastic cells characterised by their heightened capacity for tumorigenesis. These cells are implicated in the facilitation of cancer metas...
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Design and preparation of naringenin loaded functional biomimetic nano-drug delivery system for Alzheimer’s disease J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Chang Yan, Jinlian Gu, Shun Yin, Hao Wu, Xia Lei, Fang Geng, Ning Zhang, Xiaodan Wu
Efficient brain drug delivery has been a challenge in the treatment of Alzheimer’s Disease and other brain disorders as blood-brain barrier (BBB) impedes most drugs to reach brain. To overcome this...
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Clinical evaluation of liposome-based gel formulation containing glycolic acid for the treatment of photodamaged skin J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Eskandar Moghimipour, Ali Gorji, Reza Yaghoobi, Anayatollah Salimi, Mahmoud Latifi, Maryam Aghakouchakzadeh, Somayeh Handali
Background: Long contact of UV causes skin damage. Glycolic acid (GA) as an alpha hydroxy acid is used to treat photodamaged skin. However, GA leads to side effects including; burning, erythema and...
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Development of mRNA nano-vaccines for COVID-19 prevention and its biochemical interactions with various disease conditions and age groups J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Mirza Muhammad Faran Ashraf Baig, Lok Yin Wong, Hongkai Wu
This review has focused on the development of mRNA nano-vaccine and the biochemical interactions of anti-COVID-19 mRNA vaccines with various disease conditions and age groups. It studied five major...
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microRNAs: critical targets for treating rheumatoid arthritis angiogenesis J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Lingyun Zhao, Qingze Wu, Yiying Long, Qirui Qu, Fang Qi, Li Liu, Liang Zhang, Kun Ai
Vascular neogenesis, an early event in the development of rheumatoid arthritis (RA) inflammation, is critical for the formation of synovial vascular networks and plays a key role in the progression...
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Machine learning for skin permeability prediction: random forest and XG boost regression J. Drug Target. (IF 4.5) Pub Date : 2024-01-12 Kevin Ita, Joyce Prinze
Background: Machine learning algorithms that can quickly and easily estimate skin permeability (Kp) are increasingly being used in drug delivery research. The linear free energy relationship (LFER)...
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Recent advances in cancer cell bionic nanoparticles for tumour therapy J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Wanting Jiang, Yujing Lei, Cheng Peng, Donghai Wu, Jing Wu, Yiling Xu, Xinhua Xia
Nanoparticle-based drug delivery systems have found extensive use in delivering oncology therapeutics; however, some delivery vehicles still exhibit rapid immune clearance, lack of biocompatibility...
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Spanlastics: a novel elastic drug delivery system with potential applications via multifarious routes of administration J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Harshita Saini, Yugendhar Rapolu, Karan Razdan, Nirmala, Vivek Ranjan Sinha
Drug delivery systems (DDS) based on nanocarriers are designed to transport therapeutic agents to specific areas of the body where they are required to exhibit pharmacodynamic effect. These agents ...
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Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Yumeng Zhao, Xiaojie Zhang, Min An, Juntao Zhang, Yanhua Liu
Therapy on lipid metabolism is emerging as a groundbreaking cancer treatment, offering the unprecedented opportunity to effectively treat and in several cases. Tumorigenesis is inextricably linked ...
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Signalling in pancreatic cancer: from pathways to therapy J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Kexun Zhou, Yingping Liu, Shiman Yuan, Ziyu Zhou, Pengfei Ji, Qianhan Huang, Feng Wen, Qiu Li
Pancreatic cancer (PC) is a common malignant tumour in the digestive system. Due to the lack of sensitive diagnostic markers, strong metastasis ability, and resistance to anti-cancer drugs, the pro...
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Targeting WNT signalling pathways as new therapeutic strategies for osteoarthritis J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Zoya Iqbal, Jiang Xia, Ghulam Murtaza, Maryam Shabbir, Khurrum Rehman, Liang Yujie, Li Duan
Osteoarthritis (OA) is a highly prevalent chronic joint disease and the leading cause of disability. Currently, no drugs are available to control joint damage or ease the associated pain. The wingl...
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Chitosan tamarind-based nanoparticles as a promising approach for topical application of curcumin intended for burn healing: in vitro and in vivo study J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Eman S. Shalaby, Sally Aboutaleb, Shaymaa A. Ismail, Noha N. Yassen, Ahmed A. Sedik
One of the most prevalent worldwide problems that affect all ages and genders is skin burn. The goal of our study was to assess the ability of curcumin nanoparticles to cure a rat burn model. Three...
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Enhanced chemoimmunotherapy of breast cancer in mice by apolipoprotein A1-modified doxorubicin liposomes combined with interleukin-21 J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Duopeng An, Peng He, Hongchuan Liu, Rui Wang, Xiaochen Yu, Nanye Chen, Xiaohan Guo, Xiang Li, Meiqing Feng
Backgroud: Breast cancer is a prevalent malignancy among women, with triple-negative breast cancer (TNBC) comprising approximately 15–20% of all cases, possessing high invasiveness, drug resistance...
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Targeted treatment of atherosclerosis with protein–polysaccharide nanoemulsion co-loaded with photosensitiser and upconversion nanoparticles J. Drug Target. (IF 4.5) Pub Date : 2023-11-29 Jing Huang, Shan Xu, Lina Liu, Jiyuan Zhang, Jinzhuan Xu, Lili Zhang, Xiang Zhou, Lei Huang, Jianqing Peng, Jianing Wang, Zipeng Gong, Yi Chen
Macrophages are the most abundant cell group in atherosclerosis (AS) lesions and play a vital role in all stages of AS progression. Recent research has shown that reactive oxygen species (ROS) gene...
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Recent developments in nanoparticles for the treatment of diabetes J. Drug Target. (IF 4.5) Pub Date : 2023-11-16 Dinesh Kumar Sharma, Gurudutta Pattnaik, Amulyaratna Behera
Changes in the homeostasis of blood sugar levels are a hallmark of diabetes mellitus, an incurable metabolic condition, for which the first-line treatment is the subcutaneous injection of insulin. ...
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Targeted delivery of epirubicin to cancerous cell using copper sulphide nanoparticle coated with polyarginine and 5TR1 aptamer J. Drug Target. (IF 4.5) Pub Date : 2023-11-16 Fatemeh Alizadeh, Elnaz Yaghoobi, Maryam Imanimoghadam, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Chemotherapy has been widely acknowledged as a primary approach for cancer treatment. However, the administration of chemotherapy agents is often limited by their adverse effects that result from a...
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Absorption enhancer approach for protein delivery by various routes of administration: a rapid review J. Drug Target. (IF 4.5) Pub Date : 2023-11-16 Toktam Salehi, Mohammad Amin Raeisi Estabragh, Soodeh Salarpour, Mandana Ohadi, Gholamreza Dehghannoudeh
As bioactive molecules, peptides and proteins are essential in living organisms, including animals and humans. Defects in their function lead to various diseases in humans. Therefore, the use of pr...
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Desmethoxycurcumin aids IFNα’s anti-HBV activity by antagonising CRYAB reduction and stabilising IFNAR1 protein J. Drug Target. (IF 4.5) Pub Date : 2023-11-16 Jinlai Wei, Xichuan Deng, Wenying Dai, Lingxin Xie, Guangyuan Zhang, Xinyue Fan, Xinyue Li, Zhixing Jin, Qin Xiao, Tingting Chen
The eradication of chronic hepatitis B (CHB) caused by hepatitis B virus (HBV) infection is a crucial goal in clinical practice. Enhancing the anti-HBV activity of interferon type I (IFNI) is a key...
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Advancing biofilm management through nanoformulation strategies: a review of dosage forms and administration routes J. Drug Target. (IF 4.5) Pub Date : 2023-11-16 Oyku Simsekli, Irfan Bilinmis, Sumeyye Celik, Gizem Arık, Abdullah Yucel Baba, Alptug Karakucuk
Biofilms are complex microbial communities formed by the attachment of bacteria or fungi to surfaces encased in a self-produced polymeric matrix. These biofilms are highly resistant to conventional...
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The activation of SIRT1 by resveratrol reduces breast cancer metastasis to lung through inhibiting neutrophil extracellular traps J. Drug Target. (IF 4.5) Pub Date : 2023-11-16 Wenyan Yu, Zhuning Wang, Ping Dai, Jing Sun, Jian Li, Wei Han, Kaichun Li
Neutrophil extracellular traps (NETs) play a crucial role in breast cancer metastasis. However, the therapeutic target of NETs in breast cancer metastasis is still unknown. Using a natural metaboli...
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ceRNA networks in gynecological cancers progression and resistance J. Drug Target. (IF 4.5) Pub Date : 2023-11-16 Shuqin Wu, Baoshan Zhong, Yuxin Yang, Yurou Wang, Zezheng Pan
Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mecha...
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Emerging targeted therapeutic strategies for the treatment of triple-negative breast cancer J. Drug Target. (IF 4.5) Pub Date : 2023-08-29 Lakshmi Kumari, Lopamudra Mishra, Preeti Patel, Nitin Sharma, Ghanshyam Das Gupta, Balak Das Kurmi
Triple-negative breast cancer (TNBC), a subtype of breast cancer that lacks expression of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2), ...
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Relationship between ferroptosis and mitophagy in renal fibrosis: a systematic review J. Drug Target. (IF 4.5) Pub Date : 2023-08-23 Mingyu Zhang, Ziyuan Tong, Yaqing Wang, Wenjing Fu, Yilin Meng, Jiayi Huang, Li Sun
Abstract Renal fibrosis, characterised by glomerulosclerosis and tubulointerstitial fibrosis, is a typical pathological alteration in the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). However, the limited and expensive options for treating renal fibrosis place a heavy financial burden on patients and healthcare systems. Therefore, it is significant to find an effective
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Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma J. Drug Target. (IF 4.5) Pub Date : 2023-08-23 Linlin Zhang, Lei Cheng, Zhemeng Chen, Yi Fang, Changjiang Li, Min Chen, Peijie He, Haitao Wu, Jianzhang Wu, Jian Chen
Abstract Hypopharyngeal carcinoma is notorious for its poor prognosis among all head and neck cancers, posing a persistent challenge in clinical settings. The continuous hyperactivation of the NFκB signalling pathway has been noted in various cancer types, including hypopharyngeal carcinoma. In our quest to develop a novel drug that targets hypopharyngeal cancer via the NFκB pathway, we employed curcumin
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The battle of lipid-based nanocarriers against blood-brain barrier: a critical review J. Drug Target. (IF 4.5) Pub Date : 2023-08-17 Kawthar K. Abla, Mohammed M. Mehanna
Abstract Central nervous system integrity is the state of brain functioning across sensory, cognitive, emotional-social behaviors, and motor domains, allowing a person to realise his full potential. Thus, brain disorders seriously affect patients’ quality of life. Efficient drug delivery to treat brain disorders remains a crucial challenge due to numerous brain barriers, particularly the blood-brain
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In vivo application of magnetic molecularly imprinted polymer in rheumatoid arthritis rat model J. Drug Target. (IF 4.5) Pub Date : 2023-08-17 Mariam Soliman, Nagwan Shanan, Gamal Eissa, Boris Mizaikoff, Nesrine A. El Gohary
Abstract A magnetic molecularly imprinted polymer (MMIP) was synthesised and tested for an in vivo rheumatoid arthritis (RA) rat model. Magnetite coated with mesoporous silica (Fe2O3@mSi) was used as core for surface imprinting, dopamine was used as monomer and methotrexate (MTX) was loaded directly during polymerisation. The amount of MTX loaded on MMIPs reached 201.165 ± 0.315 µmol/g. Characterisation
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Exploring the efficient natural products for Alzheimer’s disease therapy via Drosophila melanogaster (fruit fly) models J. Drug Target. (IF 4.5) Pub Date : 2023-08-10 Mengdi Wu, Ying Li, Yaodong Miao, Huanhuan Qiao, Yiwen Wang
Abstract Alzheimer’s disease (AD) is a grievous neurodegenerative disorder and a major form of senile dementia, which is partially caused by abnormal amyloid-beta peptide deposition and Tau protein phosphorylation. But until now, the exact pathogenesis of AD and its treatment strategy still need to investigate. Fortunately, natural products have shown potential as therapeutic agents for treating symptoms