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Recent Developments in Bio-Ink Formulations Using Marine-Derived Biomaterials for Three-Dimensional (3D) Bioprinting Mar. Drugs (IF 5.4) Pub Date : 2024-03-16 Zied Khiari
3D bioprinting is a disruptive, computer-aided, and additive manufacturing technology that allows the obtention, layer-by-layer, of 3D complex structures. This technology is believed to offer tremendous opportunities in several fields including biomedical, pharmaceutical, and food industries. Several bioprinting processes and bio-ink materials have emerged recently. However, there is still a pressing
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Study on the Anti-Mycobacterium marinum Activity of a Series of Marine-Derived 14-Membered Resorcylic Acid Lactone Derivatives Mar. Drugs (IF 5.4) Pub Date : 2024-03-16 Qian-Qian Jing, Jun-Na Yin, Ya-Jie Cheng, Qun Zhang, Xi-Zhen Cao, Wei-Feng Xu, Chang-Lun Shao, Mei-Yan Wei
With the emergence of drug-resistant strains, the treatment of tuberculosis (TB) is becoming more difficult and there is an urgent need to find new anti-TB drugs. Mycobacterium marinum, as a model organism of Mycobacterium tuberculosis, can be used for the rapid and efficient screening of bioactive compounds. The 14-membered resorcylic acid lactones (RALs) have a wide range of bioactivities such as
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Marine Bromotyrosine Derivatives in Spotlight: Bringing Discoveries and Biological Significance Mar. Drugs (IF 5.4) Pub Date : 2024-03-14 Paula Ferreira Montenegro, Giang Nam Pham, Fatouma Mohamed Abdoul-Latif, Elisabeth Taffin-de-Givenchy, Mohamed Mehiri
The Verongida order comprises several sponge families, such as Aplysinellidae, Aplysinidae, Ianthellidae, and Pseudoceratinidae, reported for producing bromotyrosine-derived compounds. First identified in 1913, bromotyrosine derivatives have since captivated interest notably for their antitumor and antimicrobial properties. To date, over 360 bromotyrosine derivatives have been reported. Our review
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Novel [1,3,4]Thiadiazole[3,2-a]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens Mar. Drugs (IF 5.4) Pub Date : 2024-03-15 Daniela Carbone, Camilla Pecoraro, Fabio Scianò, Valentina Catania, Domenico Schillaci, Barbara Manachini, Stella Cascioferro, Patrizia Diana, Barbara Parrino
Biofilm-associated infections pose significant challenges in healthcare settings due to their resistance to conventional antimicrobial therapies. In the last decade, the marine environment has been a precious source of bioactive molecules, including numerous derivatives with antibiofilm activity. In this study, we reported the synthesis and the biological evaluation of a new series of twenty-two t
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Anti-Inflammatory Activity of Cyanobacteria Pigment Extracts: Physiological Free Radical Scavenging and Modulation of iNOS and LOX Activity Mar. Drugs (IF 5.4) Pub Date : 2024-03-12 Lécia Rodrigues, Janaína Morone, Guilherme Scotta Hentschke, Vitor Vasconcelos, Graciliana Lopes
Cyanobacteria are among the oldest organisms colonizing Earth. Their great biodiversity and ability to biosynthesize secondary metabolites through a variety of routes makes them attractive resources for biotechnological applications and drug discovery. In this pioneer study, four filamentous cyanobacteria (Cephalothrix lacustris LEGE 15493, Leptolyngbya boryana LEGE 15486, Nodosilinea nodulosa LEGE
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A Review of Cyclic Imines in Shellfish: Worldwide Occurrence, Toxicity and Assessment of the Risk to Consumers Mar. Drugs (IF 5.4) Pub Date : 2024-03-11 Sarah C. Finch, D. Tim Harwood, Michael J. Boundy, Andrew I. Selwood
Cyclic imines are a class of lipophilic shellfish toxins comprising gymnodimines, spirolides, pinnatoxins, portimines, pteriatoxins, prorocentrolides, spiro-prorocentrimine, symbiomines and kabirimine. They are structurally diverse, but all share an imine moiety as part of a bicyclic ring system. These compounds are produced by marine microalgal species and are characterized by the rapid death that
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Antioxidant Activity, Inhibition of Intestinal Cancer Cell Growth and Polyphenolic Compounds of the Seagrass Posidonia oceanica’s Extracts from Living Plants and Beach Casts Mar. Drugs (IF 5.4) Pub Date : 2024-03-11 Alkistis Kevrekidou, Andreana N. Assimopoulou, Varvara Trachana, Dimitrios Stagos, Paraskevi Malea
The aim of the present study was to investigate the use of Posidonia oceanica for making products beneficial for human health. Firstly, we demonstrated that the antioxidant defense (i.e., SOD and APX activity) of P. oceanica’s living leaves (LP) has low efficacy, as they partly neutralize the produced H2O2. However, high H2O2 levels led LP to produce, as a response to oxidative stress, high phenolic
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Induction of Autophagy by Extract from Corydalis heterocarpa for Skin Anti-Aging Mar. Drugs (IF 5.4) Pub Date : 2024-03-08 Kyeong Eun Yang, Soo-Bin Nam, Ga-Eun Lee, Gabsik Yang, Mee-Hyun Lee, Geul Bang, Jung Hoon Choi, Yong-Yeon Cho, Cheol-Jung Lee
The extracts of Corydalis heterocarpa, a salt-tolerant plant, exhibit diverse physiological properties, including anti-inflammatory, anticancer, and antiadipogenic effects. However, the anti-aging effects of C. heterocarpa extract (CHE) on human skin cells have not yet been investigated. In the present study, we determined that CHE inhibited senescence-associated β-galactosidase (SA-β-gal)-stained
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Isolation and Purification of Chitosan Oligosaccharides (Mw ≤ 1000) and Their Protective Effect on Acute Liver Injury Caused by CCl4 Mar. Drugs (IF 5.4) Pub Date : 2024-03-08 Kai Wang, Dawei Yu, Yan Bai, Hua Cao, Jiao Guo, Zhengquan Su
Chitosan oligosaccharides are the degradation products of chitin obtained from the shell extracts of shrimps and crabs. Compared with chitosan, chitosan oligosaccharides have better solubility and a wider application range. In this study, high-molecular-weight chitosan oligosaccharides (COST, chitosan oligosaccharides, MW ≤ 1000) were isolated and purified by a GPC gel column, and the molecular weight
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Mycosporine-like Amino Acids in Palmaria palmata (Rhodophyta): Specific Implication of Usujirene in Photoprotection Mar. Drugs (IF 5.4) Pub Date : 2024-03-05 Fanny Lalegerie, Valérie Stiger-Pouvreau, Solène Connan
The effect of UV radiation on the accumulation of mycosporine-like amino acids (MAAs) and pigments was investigated on red macroalga Palmaria palmata cultivated for 21 days. The data were combined with the effect of NaNO3 to further investigate the synthesis of these nitrogenous compounds. A progressive decrease in both total MAA and pigment contents was observed, with a positive effect of nitrate
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First Report of Pinnatoxin-G (PnTX-G) in a Marine–Coastal Area of the Adriatic Sea Associated with the Presence of the Dinoflagellate Vulcanodinium rugosum Mar. Drugs (IF 5.4) Pub Date : 2024-03-05 Monica Cangini, Sonia Dall’Ara, Silva Rubini, Barbara Bertasi, Paolo Rizzi, Giovanni Dell’Orfano, Stefania Milandri, Stefano Manfredini, Erika Baldini, Silvia Vertuani
This study reports the first detection of the marine neurotoxin pinnatoxin-G (PnTX-G) in clams collected in the northwestern Adriatic Sea (Italy). It also represents the first report of the potential toxin-producing dinoflagellate, Vulcanodinium rugosum, in Italian seas. This result, from the coasts of the Emilia-Romagna Region, indicates a successful colonization process, reflecting conditions in
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Effects of Polymannuronic Acid on the Intestinal Microbiota in Mice after Long-Term Intragastric Administration Mar. Drugs (IF 5.4) Pub Date : 2024-03-06 E Zhang, Qiang Wei, Xia Li, Shuliang Song
Polymannuronic acid (PM) is an alginate oligosaccharide derived from brown algae with a characterized structure and excellent biological activities. Herein, mice were given different doses of PM through 30-day-long-term intragastric administration, and the contents of the jejunum, ileum, and colon were analyzed by 16S rRNA gene sequencing technology for microbial diversity, and relevant experiments
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Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications Mar. Drugs (IF 5.4) Pub Date : 2024-03-06 Sergio Fernández, Virginia Arnáiz, Daniel Rufo, Yolanda Arroyo
Indole is a versatile pharmacophore widely distributed in bioactive natural products. This privileged scaffold has been found in a variety of molecules isolated from marine organisms such as algae and sponges. Among these, indole alkaloids represent one of the biggest, most promising family of compounds, having shown a wide range of pharmacological properties including anti-inflammatory, antiviral
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Algae-Based Supplements Claiming Weight Loss Properties: Authenticity Control and Scientific-Based Evidence on Their Effectiveness Mar. Drugs (IF 5.4) Pub Date : 2024-03-05 Fátima Fernandes, Raquel Martins, Mariana Barbosa, Patrícia Valentão
The worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements based on algae that claim to aid in weight loss, there is a notable scarcity of scientific evidence supporting their effectiveness, and their regular consumption
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Microencapsulation of Lactobacillus plantarum with Improved Survivability Using Pufferfish Skin Gelatin-Based Wall Materials Mar. Drugs (IF 5.4) Pub Date : 2024-03-05 Honghui Guo, Yelin Zhou, Quanling Xie, Hui Chen, Yiping Zhang, Zhuan Hong, Sijin Chen, Ming’en Zhang
To improve the survivability of probiotics, Lactobacillus plantarum was microencapsulated using pufferfish skin gelatin (PSG)-based wall materials by spray-drying. This work investigated the protective effect of three different pH-dependent proteins (sodium caseinate (SC), soy protein isolate (SPI), and whey protein isolate (WPI)) combined with PSG on L. plantarum. The experimental results of spray-drying
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Production of Alginate Oligosaccharides (AOSs) Using Enhanced Physicochemical Properties of Immobilized Alginate Lyase for Industrial Application Mar. Drugs (IF 5.4) Pub Date : 2024-03-04 Simranjeet Kaur, Reinu E. Abraham, Christopher M. M. Franco, Munish Puri
Alginate lyase (AL) is a polysaccharide-degrading enzyme that can degrade alginate by hydrolyzing glycosidic bonds and produces unsaturated alginate oligosaccharides (AOSs). These AOSs have wide therapeutic and nutraceutical applications. However, to produce alginate oligosaccharides in a cost-effective manner is challenging due to the low availability and high cost of this degrading enzyme. Immobilization
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Targeted Metabolite Fingerprints of Thirteen Gambierdiscus, Five Coolia and Two Fukuyoa Species Mar. Drugs (IF 5.4) Pub Date : 2024-03-02 J. Sam Murray, Emillie M. F. Passfield, Lesley L. Rhodes, Jonathan Puddick, Sarah C. Finch, Kirsty F. Smith, Roel van Ginkel, Elizabeth M. Mudge, Tomohiro Nishimura, Hiroshi Funaki, Masao Adachi, Michèle R. Prinsep, D. Tim Harwood
The genus Gambierdiscus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen Gambierdiscus, five Coolia and two Fukuyoa species (34 isolates) by assessing the production of 56 characterised secondary metabolites. Gambierdiscus polynesiensis was the only species to
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An Eco-Friendly Extraction and Purification Approach for Obtaining Active Ingredients for Cosmetics from Two Marine Brown Seaweeds Mar. Drugs (IF 5.4) Pub Date : 2024-02-28 Leslie Gager, Solène Connan, Stéphane Cérantola, Sylvain Petek, Céline Couteau, Laurence Coiffard, Valérie Stiger-Pouvreau
Brown seaweeds are attracting attention due to their richness in bioactive compounds, in particular, their phlorotannins. We present here a case study of two Fucales, Ascophyllum nodosum and Halidrys siliquosa, sustainably collected, to produce active polyphenols for the cosmetics sector. Phenolic contents of crude extracts, obtained by Accelerated Solvent Extraction (ASE), were more elevated in H
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Exploring the Potential of Crassostrea nippona Hydrolysates as Dietary Supplements for Mitigating Dexamethasone-Induced Muscle Atrophy in C2C12 Cells Mar. Drugs (IF 5.4) Pub Date : 2024-02-28 M. J. M. S. Kurera, D. P. Nagahawatta, N. M. Liyanage, H. H. A. C. K. Jayawardhana, D. S. Dissanayake, Hyo-Geun Lee, Young-Sang Kim, Sang In Kang, You-Jin Jeon
Muscle atrophy is a detrimental and injurious condition that leads to reduced skeletal muscle mass and disruption of protein metabolism. Oyster (Crassostrea nippona) is a famous and commonly consumed shellfish in East Asia and has become a popular dietary choice worldwide. The current investigation evaluated the efficacy of C. nippona against muscle atrophy, which has become a severe health issue.
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Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies Mar. Drugs (IF 5.4) Pub Date : 2024-02-28 Doralyn S. Dalisay, Chuckcris P. Tenebro, Edna M. Sabido, Angelica Faith L. Suarez, Melissa June V. Paderog, Rikka Reyes-Salarda, Jonel P. Saludes
Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting
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New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain Mar. Drugs (IF 5.4) Pub Date : 2024-02-29 Romina Gomes, Inês Mendes, Maria Paula Duarte, Narcisa M. Bandarra, Ana Gomes-Bispo
Low levels of docosahexaenoic acid (DHA) in the brain have been related to neurological disorders, like Alzheimer’s disease (AD). After ingestion, dietary DHA must cross the blood–brain barrier, where it is absorbed as lysophosphatidylcholine (LPC), due to its role as a preferential DHA carrier in the brain. This work aimed at the production of LPC-DHA extracts to be used in supplementation/food fortification
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Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus Mar. Drugs (IF 5.4) Pub Date : 2024-02-29 Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating the structure and function of the various nAChR subtypes. By studying how conotoxins interact with nAChRs, we can improve our understanding of these
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New Phenol Derivatives from the Haima Cold Seep-Derived Fungus Aspergillus subversicolor CYH-17 Mar. Drugs (IF 5.4) Pub Date : 2024-02-29 Yi-Hao Che, Wen-Ping Ding, Zhi-Hui Xiao, Jia-Min Wu, Hao Yin, Fa-Zuo Wang, Si Zhang
Seven new phenol derivatives, subversins A–E (1–5), subversic acid A (6) and epi-wortmannine G (7); one new natural product, 4-hydroxy-7-methoxyphthalide (8); and five known compounds (9–13) were isolated from the fungus Aspergillus subversicolor CYH-17 collected from the Haima cold seep. The structures and absolute configurations of these compounds were determined via NMR, MS, optical rotation, electronic
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Jasmonates and Ethylene Shape Floridoside Synthesis during Carposporogenesis in the Red Seaweed Grateloupia imbricata Mar. Drugs (IF 5.4) Pub Date : 2024-02-28 Pilar Garcia-Jimenez, Diana del Rosario-Santana, Rafael R. Robaina
Floridoside is a galactosyl–glycerol compound that acts to supply UDP-galactose and functions as an organic osmolyte in response to salinity in Rhodophyta. Significantly, the UDP-galactose pool is shared for sulfated cell wall galactan synthesis, and, in turn, affected by thallus development alongside carposporogenesis induced by volatile growth regulators, such as ethylene and methyl jasmonate, in
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Differential Proteomic Analysis of Low-Dose Chronic Paralytic Shellfish Poisoning Mar. Drugs (IF 5.4) Pub Date : 2024-02-26 Xiujie Liu, Fuli Wang, Huilan Yu, Changcai Liu, Junmei Xia, Yangde Ma, Bo Chen, Shilei Liu
Shellfish poisoning is a common food poisoning. To comprehensively characterize proteome changes in the whole brain due to shellfish poisoning, Tandem mass tag (TMT)-based differential proteomic analysis was performed with a low-dose chronic shellfish poisoning model in mice. A total of 6798 proteins were confidently identified, among which 123 proteins showed significant changes (fold changes of >1
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The Role of Sargahydroquinoic Acid and Sargachromenol in the Anti-Inflammatory Effect of Sargassum yezoense Mar. Drugs (IF 5.4) Pub Date : 2024-02-26 Yena Park, Lei Cao, Suhyeon Baek, Seungjin Jeong, Hyun Jung Yun, Mi-Bo Kim, Sang Gil Lee
The anti-inflammatory effect of the ethanol extract of Sargassum yezoense and its fractions were investigated in this study. The ethanol extract exhibited a strong anti-inflammatory effect on lipopolysaccharide-stimulated RAW 264.7 macrophages and effectively suppressed the M1 polarization of murine bone-marrow-derived macrophages stimulated by lipopolysaccharides and IFN-γ (interferon-gamma). Through
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Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation Mar. Drugs (IF 5.4) Pub Date : 2024-02-27 Hyo-Geun Lee, N. M. Liyanage, Fengqi Yang, Young-Sang Kim, Seung-Hong Lee, Seok-Chun Ko, Hye-Won Yang, You-Jin Jeon
A biocompatible, heterogeneous, fucose-rich, sulfated polysaccharide (fucoidan) is biosynthesized in brown seaweed. In this study, fucoidan was isolated from Padina arborescens (PAC) using celluclast-assisted extraction, purified, and evaluated for its anti-inflammatory potential in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Structural analyses were performed using Fourier transform infrared
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Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors Mar. Drugs (IF 5.4) Pub Date : 2024-02-27 Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Rilei Yu
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of α-CTxs have been demonstrated with improved potency compared to the native peptide. In this study, we chemically synthesized Dab/Dap-substituted analogues
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Synthesis and Hypoglycemic Effect of Insulin from the Venom of Sea Anemone Exaiptasia diaphana Mar. Drugs (IF 5.4) Pub Date : 2024-02-27 Qiqi Guo, Tianle Tang, Jingyue Lu, Meiling Huang, Junqing Zhang, Linlin Ma, Bingmiao Gao
Sea anemone venom, abundant in protein and peptide toxins, serves primarily for predatory defense and competition. This study delves into the insulin-like peptides (ILPs) present in sea anemones, particularly focusing on their role in potentially inducing hypoglycemic shock in prey. We identified five distinct ILPs in Exaiptasia diaphana, exhibiting varied sequences. Among these, ILP-Ap04 was successfully
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Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review Mar. Drugs (IF 5.4) Pub Date : 2024-02-23 Alba Ortigosa-Palomo, Francisco Quiñonero, Raul Ortiz, Francisco Sarabia, Jose Prados, Consolación Melguizo
Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide, has been extensively investigated in the last decade in terms of developing new therapeutic options that increase patient survival. In this context, marine animals are a source of new, interesting bioactive molecules that have been applied to the treatment of different types
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Metabolomics-Guided Discovery of New Dimeric Xanthones from Co-Cultures of Mangrove Endophytic Fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11 Mar. Drugs (IF 5.4) Pub Date : 2024-02-23 Jingwan Wu, Dandan Chen, Qing Li, Ting Feng, Jing Xu
The co-culture strategy, which mimics natural ecology by constructing an artificial microbial community, is a useful tool for the activation of biosynthetic gene clusters (BGCs) to generate new metabolites, as well as to increase the yield of respective target metabolites. As part of our project aiming at the discovery of structurally novel and biologically active natural products from mangrove endophytic
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Cloning and Characterization of a Novel N-Acetyl-D-galactosamine-4-O-sulfate Sulfatase, SulA1, from a Marine Arthrobacter Strain Mar. Drugs (IF 5.4) Pub Date : 2024-02-23 Monica Daugbjerg Christensen, Leila Allahgholi, Javier A. Linares-Pastén, Ólafur Friðjónsson, Hörður Guðmundsson, Varsha Kale, Roya R. R. Sardari, Guðmundur Ó. Hreggviðsson, Eva Nordberg Karlsson
Sulfation is gaining increased interest due to the role of sulfate in the bioactivity of many polysaccharides of marine origin. Hence, sulfatases, enzymes that control the degree of sulfation, are being more extensively researched. In this work, a novel sulfatase (SulA1) encoded by the gene sulA1 was characterized. The sulA1-gene is located upstream of a chondroitin lyase encoding gene in the genome
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The Presence of Bioactive Compounds in European Eel (Anguilla anguilla) Skin: A Comparative Study with Edible Tissue Mar. Drugs (IF 5.4) Pub Date : 2024-02-24 Antía Bote, Marcos Trigo, Sidonia Martínez, Santiago P. Aubourg
The presence of bioactive compounds in European eel (Anguilla anguilla) skin was studied. Proximate and lipid class compositions and analysis of the fatty acid (FA) profile (individual FAs; FA groups, i.e., saturated, monounsaturated, and polyunsaturated; FA ratios, i.e., polyunsaturated/saturated, ω3/ω6) were determined and compared to the composition of the eel muscle. As a result, higher (p < 0
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Effect of Iron Concentration on the Co-Production of Fucoxanthin and Fatty Acids in Conticribra weissflogii Mar. Drugs (IF 5.4) Pub Date : 2024-02-24 Ke Peng, David Kwame Amenorfenyo, Xiangyu Rui, Xianghu Huang, Changling Li, Feng Li
The production of fucoxanthin and fatty acids in Conticribra weissflogii has been examined, but there is still a lack of understanding regarding the impact of trace elements, including iron, on their co-production. To address this knowledge gap, this study investigated the effects of FeCl3·6H2O on the growth, fucoxanthin, and fatty acids of C. weissflogii. The findings revealed that the highest cell
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Two New Sesquiterpenoids and a New Shikimic Acid Metabolite from Mangrove Sediment-Derived Fungus Roussoella sp. SCSIO 41427 Mar. Drugs (IF 5.4) Pub Date : 2024-02-23 Zimin Xiao, Jian Cai, Ting Chen, Yilin Wang, Yixin Chen, Yongyan Zhu, Chunmei Chen, Bin Yang, Xuefeng Zhou, Huaming Tao
Two new sesquiterpenoid derivatives, elgonenes M (1) and N (2), and a new shikimic acid metabolite, methyl 5-O-acetyl-5-epi-shikimate (3), were isolated from the mangrove sediment-derived fungus Roussoella sp. SCSIO 41427 together with fourteen known compounds (4–17). The planar structures were elucidated through nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. The relative configurations
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Algae-Based Nanoparticles for Oral Drug Delivery Systems Mar. Drugs (IF 5.4) Pub Date : 2024-02-21 Eliyahu Drori, Dhaval Patel, Sarah Coopersmith, Valeria Rahamim, Chen Drori, Suchita Suryakant Jadhav, Roni Avital, Yaakov Anker, Aharon Azagury
Drug administration by oral delivery is the preferred route, regardless of some remaining challenges, such as short resident time and toxicity issues. One strategy to overcome these barriers is utilizing mucoadhesive vectors that can increase intestinal resident time and systemic uptake. In this study, biomimetic nanoparticles (NPs) were produced from 14 types of edible algae and evaluated for usage
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A Standardized Extract of Microalgae Phaeodactylum tricornutum (Mi136) Inhibit D-Gal Induced Cognitive Dysfunction in Mice Mar. Drugs (IF 5.4) Pub Date : 2024-02-21 Jonathan Maury, Antoine Delbrut, Vanessa Villard, Rémi Pradelles
The microalgae Phaeodactylum tricornutum (PT) is distinguished by its rich nutrient profile, characterized by well-documented neuroprotective activities, including fucoxanthin (FX), a major carotenoid and polyunsaturated omega-3 fatty acids (n-3 PUFA). The current study aims to evaluate the protective effects of a standardized extract of PT (Mi136) containing 2% FX on cognitive function, oxidative
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In Vitro Insights into the Role of 7,8-Epoxy-11-Sinulariolide Acetate Isolated from Soft Coral Sinularia siaesensis in the Potential Attenuation of Inflammation and Osteoclastogenesis Mar. Drugs (IF 5.4) Pub Date : 2024-02-19 Lin-Mao Ke, Dan-Dan Yu, Ming-Zhi Su, Liao Cui, Yue-Wei Guo
The balance between bone-resorbing osteoclasts and bone-forming osteoblasts is essential for the process of bone remodeling. Excessive osteoclast differentiation plays a pivotal role in the pathogenesis of bone diseases such as rheumatoid arthritis and osteoporosis. In the present study, we examined whether 7,8-epoxy-11-sinulariolide acetate (Esa), a marine natural product present in soft coral Sinularia
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Hydroxytakakiamide and Other Constituents from a Marine Sponge-Associated Fungus Aspergillus fischeri MMERU23, and Antinociceptive Activity of Ergosterol Acetate, Acetylaszonalenin and Helvolic Acid Mar. Drugs (IF 5.4) Pub Date : 2024-02-20 Harol Ricardo Arias Cardona, Bruno Cerqueira da Silva, Flávia Oliveira de Lima, Franco Henrique Andrade Leite, Bruno Cruz de Souza, Hugo Neves Brandão, Jorge Maurício David, Clayton Queiroz Alves, Anake Kijjoa
An unreported prenylated indole derivative hydroxytakakiamide (4) was isolated, together with the previously described ergosterol (1), ergosterol acetate (2), and (3R)-3-(1H-indol-3-ylmethyl)-3, 4-dihydro-1H-1,4-benzodiazepine-2,5-dione (3), from the column fractions of the crude ethyl acetate extract of the culture of a marine sponge-associated fungus, Aspergillus fischeri MMERU 23. The structure
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Marine Brown Algae-Derived Compounds as Potential Inhibitors of Japanese Encephalitis Virus RNA-Dependent RNA Polymerase Mar. Drugs (IF 5.4) Pub Date : 2024-02-17 Saud O. Alshammari
The Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that primarily affects people in Asia and seriously threatens public health. Considering the rising occurrence rates and lack of targeted antiviral treatments, it is essential to comprehend and tackle obstacles related to JEV in order to lessen its influence on world health. This investigation explores compounds derived from marine
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Influence of Nutrient Deprivation on the Antioxidant Capacity and Chemical Profile of Two Diatoms from Genus Chaetoceros Mar. Drugs (IF 5.4) Pub Date : 2024-02-19 Roberta Frleta Matas, Sanja Radman, Martina Čagalj, Vida Šimat
The limited availability of phosphate, nitrogen and silicon in the growth media affects the growth, cellular processes, and metabolism of diatoms. Silicon deficiency primarily affects diatom morphology, while phosphate deficiency reduces the production of nucleic acids and phospholipids. Differences in pigment and protein composition are mainly due to nitrogen deficiency. In this study, Chaetoceros
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Understanding the Impact of Nitrogen Availability: A Limiting Factor for Enhancing Fucoxanthin Productivity in Microalgae Cultivation Mar. Drugs (IF 5.4) Pub Date : 2024-02-18 To Quyen Truong, Yun Ji Park, Jessica Winarto, Phuong Kim Huynh, Jinyoung Moon, Yeong Bin Choi, Dae-Geun Song, Song Yi Koo, Sang Min Kim
This study aimed to investigate the regulation of fucoxanthin (FX) biosynthesis under various nitrogen conditions to optimize FX productivity in Phaeodactylum tricornutum. Apart from light, nitrogen availability significantly affects the FX production of microalgae; however, the underlying mechanism remains unclear. In batch culture, P. tricornutum was cultivated with normal (NN, 0.882 mM sodium nitrate)
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Development of Integrated Vectors with Strong Constitutive Promoters for High-Yield Antibiotic Production in Mangrove-Derived Streptomyces Mar. Drugs (IF 5.4) Pub Date : 2024-02-18 Mingxia Zhao, Zhiqiang Yang, Xinyue Li, Yaqi Liu, Yingying Zhang, Mengqian Zhang, Yangli Li, Xincheng Wang, Zixin Deng, Kui Hong, Dongqing Zhu
It is important to improve the production of bioactive secondary products for drug development. The Escherichia coli—Streptomyces shuttle vector pSET152 and its derived vector pIB139 containing a strong constitutive promoter ermEp* are commonly used as integrative vectors in actinomycetes. Four new integrative vectors carrying the strong constitutive promoter kasOp*, hrdBp, SCO5768p, and SP44, respectively
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Targeted Affinity Purification and Mechanism of Action of Angiotensin-Converting Enzyme (ACE) Inhibitory Peptides from Sea Cucumber Gonads Mar. Drugs (IF 5.4) Pub Date : 2024-02-16 Yangduo Wang, Shicheng Chen, Wenzheng Shi, Shuji Liu, Xiaoting Chen, Nan Pan, Xiaoyan Wang, Yongchang Su, Zhiyu Liu
Protein hydrolysates from sea cucumber (Apostichopus japonicus) gonads are rich in active materials with remarkable angiotensin-converting enzyme (ACE) inhibitory activity. Alcalase was used to hydrolyze sea cucumber gonads, and the hydrolysate was separated by the ultrafiltration membrane to produce a low-molecular-weight peptide component (less than 3 kDa) with good ACE inhibitory activity. The peptide
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Brown Algae Dictyopteris divaricata Attenuates Adipogenesis by Modulating Adipocyte Differentiation and Promoting Lipolysis through Heme Oxygenase-1 Activation in 3T3-L1 Cells Mar. Drugs (IF 5.4) Pub Date : 2024-02-16 Lakshi A. Dayarathne, Seok-Chun Ko, Mi-Jin Yim, Jeong Min Lee, Ji-Yul Kim, Gun-Woo Oh, Chul Hwan Kim, Kyung Woo Kim, Dae-Sung Lee, Jae-Young Je
The present study aims to explore the probable anti-adipogenesis effect of Dictyopteris divaricata (D. divaricata) in 3T3-L1 preadipocytes by regulating heme oxygenase-1 (HO-1). The extract of D. divaricata retarded lipid accretion and decreased triglyceride (TG) content in 3T3-L1 adipocytes but increased free glycerol levels. Treatment with the extract inhibited lipogenesis by inhibiting protein expressions
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Synthesis of Bioactive Nickel Nanoparticles Using Bacterial Strains from an Antarctic Consortium Mar. Drugs (IF 5.4) Pub Date : 2024-02-14 Joseph Amruthraj Nagoth, Maria Sindhura John, Kesava Priyan Ramasamy, Alessio Mancini, Marco Zannotti, Sara Piras, Rita Giovannetti, Lydia Rathnam, Cristina Miceli, Maria Chiara Biondini, Sandra Pucciarelli
Marine microorganisms have been demonstrated to be an important source for bioactive molecules. In this paper we report the synthesis of Ni nanoparticles (NiSNPs) used as reducing and capping agents for five bacterial strains isolated from an Antarctic marine consortium: Marinomonas sp. ef1, Rhodococcus sp. ef1, Pseudomonas sp. ef1, Brevundimonas sp. ef1, and Bacillus sp. ef1. The NiSNPs were characterized
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Synthetic Antimicrobial Peptides Fail to Induce Leucocyte Innate Immune Functions but Elicit Opposing Transcriptomic Profiles in European Sea Bass and Gilthead Seabream Mar. Drugs (IF 5.4) Pub Date : 2024-02-14 Laura Cervera, Elena Chaves-Pozo, Alberto Cuesta
Antimicrobial peptides (AMPs) are promising molecules in diverse fields, including aquaculture. AMPs possess lytic effects on a wide range of pathogens, resulting in a potential replacement for traditional antimicrobials in aquaculture. In addition, they also have modulatory effects on host immune responses. Thus, the objective of this work was to evaluate the immunomodulatory capability of three known
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Meirols A–C: Bioactive Catecholic Compounds from the Marine-Derived Fungus Meira sp. 1210CH-42 Mar. Drugs (IF 5.4) Pub Date : 2024-02-14 Min Ah Lee, Jong Soon Kang, Jeong-Wook Yang, Hwa-Sun Lee, Chang-Su Heo, Sun Joo Park, Hee Jae Shin
Three new catecholic compounds, named meirols A–C (2–4), and one known analog, argovin (1), were isolated from the marine-derived fungus Meira sp. 1210CH-42. Their structures were determined by extensive analysis of 1D, 2D NMR, and HR-ESIMS spectroscopic data. Their absolute configurations were elucidated based on ECD calculations. All the compounds exhibited strong antioxidant capabilities with EC50
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Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells Mar. Drugs (IF 5.4) Pub Date : 2024-02-14 Sultan Pulat, Inho Yang, Jihye Lee, Sunghoon Hwang, Rui Zhou, Chathurika D. B. Gamage, Mücahit Varlı, İsa Taş, Yi Yang, So-Yeon Park, Ahreum Hong, Jeong-Hyeon Kim, Dong-Chan Oh, Hangun Kim, Sang-Jip Nam, Heonjoong Kang
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly
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Anti-Inflammatory and Immunomodulatory Properties of a Crude Polysaccharide Derived from Green Seaweed Halimeda tuna: Computational and Experimental Evidences Mar. Drugs (IF 5.4) Pub Date : 2024-02-11 Marwa Kraiem, Sonia Ben Hamouda, Malek Eleroui, Marwa Ajala, Amal Feki, Amel Dghim, Zakaria Boujhoud, Marwa Bouhamed, Riadh Badraoui, Jean Marc Pujo, Khadija Essafi-Benkhadir, Hatem Kallel, Ibtissem Ben Amara
In this study, we investigated for the first time the anti-inflammatory and immunomodulatory properties of crude polysaccharide (PSHT) extracted from green marine algae Halimeda tuna. PSHT exhibited anti-oxidant activity in vitro through scavenging 1, 1-diphenyl-2-picryl hydroxyl free radical, reducing Fe3+/ferricyanide complex, and inhibiting nitric oxide. PSHT maintained the erythrocyte membrane
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Identification of PLK1-PBD Inhibitors from the Library of Marine Natural Products: 3D QSAR Pharmacophore, ADMET, Scaffold Hopping, Molecular Docking, and Molecular Dynamics Study Mar. Drugs (IF 5.4) Pub Date : 2024-02-10 Nan Zhou, Chuangze Zheng, Huiting Tan, Lianxiang Luo
PLK1 is found to be highly expressed in various types of cancers, but the development of inhibitors for it has been slow. Most inhibitors are still in clinical stages, and many lack the necessary selectivity and anti-tumor effects. This study aimed to create new inhibitors for the PLK1-PBD by focusing on the PBD binding domain, which has the potential for greater selectivity. A 3D QSAR model was developed
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Effects of Ultrasonic Power on the Structure and Rheological Properties of Skin Collagen from Albacore (Thunnus alalunga) Mar. Drugs (IF 5.4) Pub Date : 2024-02-10 Hao Pan, Xuehua Zhang, Jianbo Ni, Qianqian Liang, Xin Jiang, Zihui Zhou, Wenzheng Shi
The effects of ultrasonic power (0, 150, 300, 450, and 600 W) on the extraction yield and the structure and rheological properties of pepsin-soluble collagen (PSC) from albacore skin were investigated. Compared with the conventional pepsin extraction method, ultrasonic treatment (UPSC) significantly increased the extraction yield of collagen from albacore skin, with a maximum increase of 8.56%. The
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Structure and Binding Properties to Blood Co-Factors of the Least Sulfated Galactan Found in the Cell Wall of the Red Alga Botryocladia occidentalis Mar. Drugs (IF 5.4) Pub Date : 2024-02-09 Antim K. Maurya, Hoda Al. Ahmed, Anderson DeWitt, Anter A. Shami, Sandeep K. Misra, Vitor H. Pomin
Three different populations of sulfated polysaccharides can be found in the cell wall of the red alga Botryocladia occidentalis. In a previous work, the structures of the were revised. In this work, NMR-based structural analysis was performed on the least sulfated polysaccharide and its chemically modified derivatives. Results have revealed the presence of both 4-linked α- and 3-linked β-galactose
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Reconstruction of Long-Chain Polyunsaturated Acid Synthesis Pathways in Marine Red Microalga Porphyridium cruentum Using Lipidomics and Transcriptomics Mar. Drugs (IF 5.4) Pub Date : 2024-02-09 Tao Li, Chulin Li, Weinan Wang, Hualian Wu, Houbo Wu, Jin Xu, Wenzhou Xiang
The marine red microalga Porphyridium can simultaneously synthesize long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (C20:5, EPA) and arachidonic acid (C20:4, ARA). However, the distribution and synthesis pathways of EPA and ARA in Porphyridium are not clearly understood. In this study, Porphyridium cruentum CCALA 415 was cultured in nitrogen-replete and nitrogen-limited conditions
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Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp. Mar. Drugs (IF 5.4) Pub Date : 2024-02-03 Zequan Huang, Dong Liu, Shang Chen, Jinwei Ren, Chenghai Gao, Zhiyong Li, Aili Fan, Wenhan Lin
Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds 6–10 and 16 exhibited significant
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Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders Mar. Drugs (IF 5.4) Pub Date : 2024-02-06 Mariam Alhattab, Lakshana S. Moorthy, Durva Patel, Christopher M. M. Franco, Munish Puri
The products of oleaginous microbes, primarily lipids, have gained tremendous attention for their health benefits in food-based applications as supplements. However, this emerging biotechnology also offers a neuroprotective treatment/management potential for various diseases that are seldom discussed. Essential fatty acids, such as DHA, are known to make up the majority of brain phospholipid membranes
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Current Research Status of Azaspiracids Mar. Drugs (IF 5.4) Pub Date : 2024-02-04 Jiaping Yang, Weiqin Sun, Mingjuan Sun, Yunyi Cui, Lianghua Wang
The presence and impact of toxins have been detected in various regions worldwide ever since the discovery of azaspiracids (AZAs) in 1995. These toxins have had detrimental effects on marine resource utilization, marine environmental protection, and fishery production. Over the course of more than two decades of research and development, scientists from all over the world have conducted comprehensive
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The Role of Natural and Synthetic Flavonoids in the Prevention of Marine Biofouling Mar. Drugs (IF 5.4) Pub Date : 2024-02-02 Daniela Pereira, Madalena Pinto, Joana R. Almeida, Marta Correia-da-Silva, Honorina Cidade
Marine biofouling is a major concern for the maritime industry, environment, and human health. Biocides which are currently used in marine coatings to prevent this phenomenon are toxic to the marine environment, and therefore a search for antifoulants with environmentally safe properties is needed. A large number of scientific papers have been published showing natural and synthetic compounds with
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The Screening and Identification of a Dextranase-Secreting Marine Actinmycete Saccharomonospora sp. K1 and Study of Its Enzymatic Characteristics Mar. Drugs (IF 5.4) Pub Date : 2024-01-28 Boyan Wang, Yizhuo Wu, Qiang Li, Xudong Wu, Xinxin Kang, Lei Zhang, Mingsheng Lyu, Shujun Wang
In this study, an actinomycete was isolated from sea mud. The strain K1 was identified as Saccharomonospora sp. by 16S rDNA. The optimal enzyme production temperature, initial pH, time, and concentration of the inducer of this actinomycete strain K1 were 37 °C, pH 8.5, 72 h, and 2% dextran T20 of medium, respectively. Dextranase from strain K1 exhibited maximum activity at 8.5 pH and 50 °C. The molecular
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Chemical and Pharmacological Prospection of the Ascidian Cystodytes dellechiajei Mar. Drugs (IF 5.4) Pub Date : 2024-01-31 Pedro Jatai Batista, Genoveffa Nuzzo, Carmela Gallo, Dalila Carbone, Mario dell’Isola, Mario Affuso, Giusi Barra, Federica Albiani, Fabio Crocetta, Riccardo Virgili, Valerio Mazzella, Daniela Castiglia, Giuliana d’Ippolito, Emiliano Manzo, Angelo Fontana
Marine invertebrates are a traditional source of natural products with relevant biological properties. Tunicates are soft-bodied, solitary or colonial, sessile organisms that provide compounds unique in their structure and activity. The aim of this work was to investigate the chemical composition of the ascidian Cystodytes dellechiajei, selected on the basis of a positive result in biological screening