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Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Shihao Chen, Wenqiang Fang, Linqian Zhao, Huiqin Xu
Objective:This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering the third quarter of 2020 to the second quarter of 2023.Methods:Data related to cenobamate-associated ADEs from the third quarter of 2020 to the second quarter of 2023 were collected. After standardizing the data, various signal quantification techniques, including ROR, MHRA
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Integration of meta-analysis and network pharmacology analysis to investigate the pharmacological mechanisms of traditional Chinese medicine in the treatment of hepatocellular carcinoma Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Jie Lin, Huaijuan Guo, Hanjiao Qin, Xuewen Zhang, Jiyao Sheng
Background: This study will explore the therapeutic value of traditional Chinese medicine (TCM) in Hepatocellular Carcinoma (HCC) through meta-analysis, combined with network pharmacology analysis.Methods: The results of randomized controlled trials on TCM and HCC were retrieved and summarized from multiple databases. The effective active com-pounds and target genes of the high-frequency TCM were obtained
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Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Marta Llansola, Yaiza M. Arenas, María Sancho-Alonso, Gergana Mincheva, Andrea Palomares-Rodriguez, Magnus Doverskog, Paula Izquierdo-Altarejos, Vicente Felipo
Enhanced GABAergic neurotransmission contributes to impairment of motor coordination and gait and of cognitive function in different pathologies, including hyperammonemia and hepatic encephalopathy. Neuroinflammation is a main contributor to enhancement of GABAergic neurotransmission through increased activation of different pathways. For example, enhanced activation of the TNFα–TNFR1-NF-κB-glutaminase-GAT3
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Effects of a proprietary mixture of extracts from Sabal serrulata fruits and Urtica dioica roots (WS® 1541) on prostate hyperplasia and inflammation in rats and human cells Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Carla Sens-Albert, Sabrina Weisenburger, Beatrix C. König, Silas F. Melcher, Ulrike A. M. Scheyhing, Karin Rollet, Philippe Lluel, Egon Koch, Martin D. Lehner, Martin C. Michel
Introduction: Phytotherapeutics, particularly extracts from Sabal serrulata (saw palmetto) fruit or Urtica dioica (stinging nettle) root, are popular for the treatment of male lower urinary symptoms in many countries, but their mechanism of action is poorly understood. We performed in vivo and in vitro studies to obtain deeper insight into the mechanism of action of WS® 1541, a proprietary combination
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Chinese patent medicine combined with calcium channel blockers in the treatment of essential hypertension:a Bayes network meta-analysis and systematic review Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Liangyu Cui, Xingfang Liu, Yukun Li, Tianyue Jing, Dasheng Liu, Cong Ren, Tong Yin, Yu Wang, Zhiwei Zhao, Jiaheng Wang, Xuejie Han, Liying Wang
Backgroud: The co-administration of Chinese patent medicine with calcium channel blockers (CCBs) is a prevalent practice in China for treating essential hypertension (EH). However, robust evidence supporting the efficacy and safety of tailored combinations of different Chinese patent medicines with CCBs, according to individual patient conditions, is still limited. This study sought to elucidate the
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Ceftriaxone-induced severe hemolytic anemia, renal calculi, and cholecystolithiasis in a 3-year-old child: a case report and literature review Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Enfu Tao, Huangjia Zhou, Meili Zheng, Yisha Zhao, Junfen Zhou, Junhui Yuan, Tianming Yuan, Changhua Zheng
Ceftriaxone is widely used in pediatric outpatient care for its efficacy against respiratory and digestive system infections, yet its increasing association with severe immune hemolytic reactions requires heightened vigilance from pediatricians. This report details a rare and severe case of ceftriaxone-induced severe immune hemolytic anemia (IHA), hemolytic crisis, myocardial injury, liver injury,
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Efficacy of turmeric in the treatment of oral mucositis in patients with head and neck cancer after radiotherapy or chemoradiotherapy: a systematic review and meta-analysis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Chiu-Feng Wu, Hui-Juan Wu, Chia-Lung Shih, Tzu-Pei Yeh, Wei-Fen Ma
BackgroundOral mucositis is a major complication for head and neck cancer (HNC) patients after radiotherapy or chemotherapy. A meta-analysis was performed to assess the efficacy of turmeric in the treatment of oral mucositis in HNC patients.MethodsRandomized controlled trials investigating our topic were included in the meta-analysis. The clinical outcomes considered were the severity of oral mucositis
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Integration of transcriptomics and metabolomics reveals toxicological mechanisms of ZhuRiHeng drop pill in the 180-day repeated oral toxicity study Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-15 Qian Zhang, Fang Wang, Jing Liu, Jun Li, Wei Zhang, Shengsang Na, Jingkun Lu, Yuewu Wang
Background: ZhuRiHeng Drop Pill (ZRH) is a traditional Mongolian medicinal preparation. Despite its long history of use for the treatment of coronary heart disease, there have been few toxicological studies of the safety profile of ZRH.Purpose: In order to comprehensively elucidate the underlying mechanisms behind the observed toxicity of ZRH on rat livers in the 180-day repeated oral toxicity study
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Identification of key genes increasing susceptibility to atrial fibrillation in nonalcoholic fatty liver disease and the potential mechanisms: mitochondrial dysfunction and systemic inflammation Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Baiyin Zhong, Zhonghui Xie, Jianhong Zhang, Xing Xie, Yuankang Xie, Binhui Xie, Jing Wang, Chuanbin Liu
Background: Non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) are major health burdens, with emerging evidence suggesting NAFLD as a significant risk factor for AF, but the mechanism is remain unclear.Methods: In this study, we analyzed gene expression data from NAFLD (GSE89632) and AF (GSE75092) datasets from the Gene Expression Omnibus. We identified co-upregulated and co-downregulated
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Probes for the heterogeneity of muscimol binding sites in rat brain Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Veronika Müller, Margot Ernst, Aygul Baykuchkarova, Filip Koniuszewski, Konstantina Bampali, Thomas Seidel, Petra Scholze
Introduction: The plant-based alkaloid muscimol is a potent agonist of inhibitory GABAA-neurotransmitter receptors. GABAA receptors are a heterogeneous family of pentameric complexes, with 5 out of 19 subunits assembling around the central anion pore. Muscimol is considered to bind to all receptor subtypes at the orthosteric drug binding site at the β+/α− interface. Recently, we observed that the antipsychotic
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Model-based exploration of the rationality of off-label use of cetirizine in Chinese pediatric patients: a prospective cohort study Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Wei Liu, Zhiyuan Tan, Ping Yang, Zhiheng Yu, Xueting Yao, Pengxiang Zhou, Ling Liu, Wei Zhou
Aims: Cetirizine is frequently administered at an increased dosage in clinical practice and recommended by several guidelines. Nonetheless, the pharmacokinetic (PK) profile and real-world safety data remain insufficient in the Chinese pediatric population. The objective of the current study is to develop a population pharmacokinetic (PPK) model for cetirizine in Chinese pediatric patients and to investigate
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Effectiveness of prophylactic antibacterial drugs for patients with liver cirrhosis and upper gastrointestinal bleeding: a systematic review and meta-analysis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Zhuo Wang, Han-Shuo Hu, Li-Mei Zhao, Yu Li, Xiao-Dong Liu
Background: Prophylactic antibacterial drugs are used for patients with liver cirrhosis and upper gastrointestinal bleeding, and independent studies have concluded that they can decrease the rate of infection, mortality, and rebleeding in these diseases. However, no comprehensive assessment of this effect has been reported in recent years and available data pertaining to the prognostic implications
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In-depth LC-MS and in-vitro studies of a triterpenoid saponin capilliposide-A metabolism modulation in gut microbiota of mice Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Huan Zhao, Xueli Hu, Shenghong Guan, Jinhong Cai, Xiaohan Li, Jiaxi Fang, Bo Lin, Wei Zhu, Jingkui Tian, Juan Jin, Qiang He, Xiaoyong Zhang
Introduction: Some herbal ingredients can reshape the composition of the gut microbiome as well as its metabolites. At the same time, the gut microbiota can also affect drug metabolism. A large number of studies have reported that saponins are biotransformed under the action of intestinal microorganisms to improve drug efficacy and bioavailability. Capilliposide A is a triterpenoid saponin, which is
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CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Cataldo Martucci, Andrew Dennis Allen, Nadia Moretto, Valentina Bagnacani, Alessandro Fioni, Riccardo Patacchini, Maurizio Civelli, Gino Villetti, Fabrizio Facchinetti
Inhibition of p38 mitogen-activated protein kinase (MAPKs) is a potential therapeutic approach for the treatment of acute and chronic pulmonary inflammatory conditions. Here, we report the in vitro and in vivo characterization of the anti-inflammatory effects of CHF6297, a novel potent and selective p38α inhibitor designed for inhalation delivery as a dry powder formulation. CHF6297 has been proven
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Post-marketing safety evaluation of lurbinectedin: a pharmacovigilance analysis based on the FAERS database Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Zhao Li, Changying Guo, Xingfei Liu, Zhengzhou Qiu, Ruilin Zhang
Background: On 15 June 2020, the United States Food and Drug Administration (FDA) approved lurbinectedin for treating adult patients with metastatic small-cell lung cancer whose disease has progressed despite prior platinum-based chemotherapy. Following its market approval, safety data on lurbinectedin in large populations is currently lacking. Therefore, this study aims to evaluate adverse events
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Prevalence of use of on-label and off-label psychotropics in the Greek pediatric population Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Stella Pesiou, Rafel Barcelo, Georgios Papazisis, Ferran Torres, Caridad Pontes
With a global increased use of psychotropics in pediatrics, their off-label use is a concern due to uncertainty and risk. Data on psychotropics use in the Greek pediatric population do not exist to date. We analyzed retrospective data from the nationwide pharmacy claim database, to estimate the prevalence of psychotropics in pediatrics focusing on off-label use (March 2016-October 2019). In total 63
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Sedum aizoon L.: a review of its history, traditional uses, nutritional value, botany, phytochemistry, pharmacology, toxicology, and quality control Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Bai-Ling Wang, Zhen-Kai Ge, Jing-Ran Qiu, Si-Qi Luan, Xin-Cai Hao, Yong-Heng Zhao
In China, Russia, Mongolia, Japan, North Korea, and Mexico, Sedum aizoon L. (S. aizoon) is used as an edible plant. Up to now, over 234 metabolites, including phenolic acids, flavonoids, triterpenes, phytosterols, and alkaloids, among others, have been identified. In addition to its antioxidant, anti-inflammatory, anti-fatigue, antimicrobial, anti-cancer, and hemostatic activities, S. aizoon is used
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Methanol extract of Ligusticum chuanxiong Hort. Rhizome ameliorates bilateral common carotid artery stenosis-induced cognitive deficit in mice by altering microglia and astrocyte activation Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Sehyun Lim, Chiyeon Lim, Suin Cho
In traditional Asian medicine, Ligusticum chuanxiong Hort also known as Conioselinum anthriscoides “Chuanxiong”, is mainly used for improving blood circulation or for analgesic and anti-inflammatory purposes, but they also have a long history of use for pain disorders in the head and face, such as headache. Despite the possibility that the plant is effective for diseases such as cerebral infarction
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Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-14 Yi Wu, Feng Zhang, Dan Kuang, Dan Li, Jiai Yan, Ju Yang, Qinyue Wang, Yingyu Wang, Jing Sun, Yiran Liu, Yanping Xia, Hong Cao
Background: In clinical practice, antibiotics and/or inhaled or oral hormone preparations are the first line of treatment for chronic pharyngitis. However, this therapeutic regimen is not satisfactory enough. At present, medicinal plants as dietary supplements or functional foods are widely recognized for the treatment and prevention of different diseases.Purpose: This study aimed to evaluate the efficacy
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Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Yixuan Zheng, Hui Wang, Xueying Li, Jing Xie, Junming Fan, Sichong Ren
Chronic kidney disease (CKD) is a progressive disorder characterized by structural and functional changes in the kidneys, providing a global health challenge with significant impacts on mortality rates. Extracellular vesicles (EVs), are vital in the physiological and pathological processes associated with CKD. They have been shown to modulate key pathways involved in renal injury, including inflammation
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The protective effects of ligustrazine on ischemic stroke: a systematic review and meta-analysis of preclinical evidence and possible mechanisms Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Ziming Wang, Zihong Wu, Yifan Miao, Aohan Hao, Hao Chen, Shuang Zhao, Min Luo, Shihan Guo, Yingming Liu, Yun Lu
Introduction: The objective of this study is to systematically evaluate the effect of ligustrazine on animal models of ischemic stroke and investigate its mechanism of action.Materials and Methods: The intervention of ligustrazine in ischemic diseases research on stroke model animals was searched in the Chinese National Knowledge Infrastructure (CNKI), Wanfang Database (Wanfang), VIP Database (VIP)
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Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Winnie S. Liang, Brett Beaulieu-Jones, Susan Smalley, Michael Snyder, Laura H. Goetz, Nicholas J. Schork
In recent years, the development of sensor and wearable technologies have led to their increased adoption in clinical and health monitoring settings. One area that is in early, but promising, stages of development is the use of biosensors for therapeutic drug monitoring (TDM). Traditionally, TDM could only be performed in certified laboratories and was used in specific scenarios to optimize drug dosage
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Impact of treatment adherence and inhalation technique on asthma outcomes of pediatric patients: a longitudinal study Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Catalina Lizano-Barrantes, Olatz Garin, Karina Mayoral, Alexandra L. Dima, Angels Pont, María Araceli Caballero-Rabasco, Manuel Praena-Crespo, Laura Valdesoiro-Navarrete, María Teresa Guerra, Alberto Bercedo-Sanz, Montse Ferrer
Introduction: We aimed to evaluate the longitudinal relationships, both at between- and within-person levels, that adherence to inhaled corticosteroid-based maintenance treatment and inhalation technique present with symptom control, exacerbations, and health-related quality of life (HRQoL) in children and adolescents with asthma.Methods: Participants (6–14 years old) from the ARCA (Asthma Research
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Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Jindu Zhao, Guo-Ying Li, Xian-Ying Lu, Li-Ran Zhu, Qun Gao
Liver cancer remains as the third leading cause of cancer-related death globally as of 2020. Despite the significant progress made in the field of liver cancer treatment, there is still a lack of effective therapies in patients with advanced cancer and the molecular mechanisms underlying liver cancer progression remain largely elusive. N6-methyladenosine (m6A) modification, as the most prevalent and
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Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Introduction:Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies has led to significant health improvements in individuals with this mutation. While numerous animal models of CF exist, few have a CFTR mutation that
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Development of a prognostic model based on different disulfidptosis related genes typing for kidney renal clear cell carcinoma Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Yuanyuan Feng, Wenkai Wang, Shasha Jiang, Yongming Liu, Yan Wang, Xiangyang Zhan, Huirong Zhu, Guoqing Du
Background: Kidney renal clear cell carcinoma (KIRC) is a common and clinically significant subtype of kidney cancer. A potential therapeutic target in KIRC is disulfidptosis, a novel mode of cell death induced by disulfide stress. The aim of this study was to develop a prognostic model to explore the clinical significance of different disulfidptosis gene typings from KIRC.Methods: A comprehensive
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Diuretic drug utilization in neonates: a French prescription database analysis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Silvia Iacobelli, Simon Lorrain, Ezira Rabe, Béatrice Gouyon, Jean-Bernard Gouyon, Francesco Bonsante
Background: The use of diuretics is extremely common in infants cared for in neonatal wards, despite the lack of proven efficacy for many conditions. The main objective of this study was to assess the rate of diuretics exposure in a multicenter French cohort. The secondary objectives were to describe the evolution of this exposure over time, the indications, the prescription practices, and the exposure
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The protective effect of traditional Chinese medicine Jinteng Qingbi granules on rats with rheumatoid arthritis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Yingying Wan, Wenting Sun, Jiaxi Yang, Haonan Wang, Wenqian Wang, Wanting Ye, Guoliang Cheng, Bing Li, Jianxun Ren, Qiuai Kou
Introduction: Jinteng Qingbi granules (JTQBG), a traditional Chinese medicine formulation, are widely used for the treatment of rheumatoid arthritis (RA) due to their satisfactory therapeutic efficacy. However, the underlying mechanism of action remains unclear. This study aims to investigate the protective effects of JTQBG against RA and elucidates its potential molecular mechanisms.Methods: A collagen-induced
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Different biologics for biological-naïve patients with psoriatic arthritis: a systematic review and network meta-analysis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Jixia Lin, Yougang Ren
Aim: To systematically compare the efficacy and safety of biologics [tumor necrosis factor inhibitors (TNFi), interleukin (IL) inhibitors, phosphodiesterase-4 inhibitors (PDE4i), and Janus kinase inhibitors (JAKi)] for biological-naïve patients with psoriatic arthritis (PsA).Methods: PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched until 12 March 2023. Only head-to-head
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Effectiveness and safety of Danshen injections in treatment of cardiac failure: a network meta-analysis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Yuchen Song, Nan Song, Lianqun Jia, Yupeng Pei
Objective: The purpose of this network meta-analysis (NMA) was to compare the therapeutic effects of various Danshen (Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma]) injections on heart failure to determine the optimal Danshen injection combined with conventional treatment.Methods: 8 databases were searched from the inception of these databases to May 2023 to collect
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Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-13 Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
The family of pH (Low) Insertion Peptides (pHLIP) comprises a tumor-agnostic technology that uses the low pH (or high acidity) at the surfaces of cells within the tumor microenvironment (TME) as a targeted biomarker. pHLIPs can be used for extracellular and intracellular delivery of a variety of imaging and therapeutic payloads. Unlike therapeutic delivery targeted to specific receptors on the surfaces
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New light on changes in the number and function of blood platelets stimulated by cocoa and its products Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Beata Olas
Hyperactivation of blood platelets, one of the causes of heart attack, and other cardiovascular diseases (CVDs), is influenced by various dietary components, including phenolic compounds from vegetables, fruits, teas, wines, cocoa and its products, including chocolate. The present paper sheds new light on the effect of cocoa and its products, especially dark chocolate, on the number and function of
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Forcing a square into a circle: why South Africa’s draft revised material transfer agreement is not fit for purpose Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Paul Esselaar, Lee Swales, Devarasi Bellengère, Banele Mhlongo, Donrich Thaldar
The South African National Health Research Ethics Council (NHREC) recently released a final draft revision of the standard material transfer agreement (MTA) that was promulgated into law in 2018. This new draft MTA raises pertinent questions about the NHREC’s mandate, the way in which the draft MTA deals with data and with human biological material, and its avoidance of the concept of ownership. After
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The Prescription trends and dosing appropriateness analysis of novel oral anticoagulants in ischemic stroke patients: a retrospective study of 9 cities in China Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Mingfen Wu, Hailun Jiang, Kefu Yu, Zhigang Zhao, Bin Zhu
Background: Novel oral anticoagulants (NOACs) have been recommended by guidelines as the first-line drugs for preventing cardiogenic stroke. We aimed to provide an overview of the prescription trends and dosing appropriateness of NOACs in China.Methods: We conducted a retrospective analysis of NOAC prescriptions using the Hospital Prescription Analysis Cooperation Project data from 2016 to 2022. Various
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Berberine-based self-assembly agents with enhanced synergistic antitumor efficacy Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Yun Wang, Zhongrui Li, Haili Zhang, Peiye Wu, Yu Zhao, Renshi Li, Chao Han, Lei Wang
Tumors are still a major threat to people worldwide. Nanodrug delivery and targeting systems can significantly improve the therapeutic efficacy of chemotherapeutic drugs for antitumor purposes. However, many nanocarriers are likely to exhibit drawbacks such as a complex preparation process, limited drug-loading capacity, untargeted drug release, and toxicity associated with nanocarriers. Therefore
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Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Wesam H. Abdulaal, Nabil A. Alhakamy, Amer H. Asseri, Mohamed F. Radwan, Tarek S. Ibrahim, Solomon Z. Okbazghi, Hisham A. Abbas, Basem Mansour, Aly A. Shoun, Wael A. H. Hegazy, Mahmoud Saad Abdel-Halim
The development of resistance to carbapenems in Klebsiella pneumoniae due to the production of metallo-β-lactamases (MBLs) is a critical public health problem because carbapenems are the last-resort drugs used for treating severe infections of extended-spectrum β-lactamases (ESBLs) producing K. pneumoniae. Restoring the activity of carbapenems by the inhibition of metallo-β-lactamases is a valuable
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Antiretroviral drugs from multiple classes induce loss of excitatory synapses between hippocampal neurons in culture Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Hannah M. McMullan, Benjamin M. Gansemer, Stanley A. Thayer
Introduction: Antiretroviral (ARV) drugs have improved prognoses for people living with HIV. However, HIV-associated neurocognitive disorders (HAND) persist despite undetectable viral loads. Some ARVs have been linked to neuropsychiatric effects that may contribute to HAND. Synapse loss correlates with cognitive decline in HAND and synaptic deficits may contribute to the neuropsychiatric effects of
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Naodesheng decoction regulating vascular function via G-protein-coupled receptors: network analysis and experimental investigations Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Shuhan Chen, Ziran Niu, Yanjia Shen, Wendan Lu, Jiaying Zhao, Huilin Yang, Minmin Guo, Li Zhang, Ruifang Zheng, Guanhua Du, Li Li
Introduction: Ischemic stroke (IS) is a detrimental neurological disease with limited treatment options. Recanalization of blocked blood vessels and restoring blood supply to ischemic brain tissue are crucial for post-stroke rehabilitation. The decoction Naodesheng (NDS) composed of five Chinese botanical drugs, including Panax notoginseng (Burk.) F. H. Chen, Ligusticum chuanxiong Hort., Carthamus
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An in vitro study to elucidate the effects of product Nkabinde on immune response in peripheral blood mononuclear cells of healthy donors Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Boitumelo Setlhare, Marothi Letsoalo, Siphathimandla Authority Nkabinde, Magugu Nkabinde, Gugulethu Mzobe, Andile Mtshali, Sobia Parveen, Samukelisiwe Ngcobo, Luke Invernizzi, Vinesh Maharaj, Mlungisi Ngcobo, Nceba Gqaleni
Introduction: A significant number of the South African population still rely on traditional medicines (TM) as their primary healthcare due to their belief in their holistic healing and immune-boosting properties. However, little to no scientific data is available on the effects of most TM products on cytokine and cellular biomarkers of the immune response. Here, we evaluated the impact of traditional
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Korean red ginseng extract prevents bone loss in an oral model of glucocorticoid induced osteoporosis in mice Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Nicholas J. Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R. McCabe, Narayanan Parameswaran
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut barrier function. Korean Red Ginseng (KRG, Panax Ginseng Meyer, Araliaceae) extract has been shown to prevent glucocorticoid-induced osteoporosis (GIO) in
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A real-world disproportionality analysis of Everolimus: data mining of the public version of FDA adverse event reporting system Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-12 Bin Zhao, Yumei Fu, Shichao Cui, Xiangning Chen, Shu Liu, Lan Luo
Background: Everolimus is an inhibitor of the mammalian target of rapamycin and is used to treat various tumors. The presented study aimed to evaluate the Everolimus-associated adverse events (AEs) through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS).Methods: The AE records were selected by searching the FDA Adverse Event Reporting System database from the
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Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Ning Tang, Yan Wang, Jiarui Miao, Yang Zhao, Yue Cao, Wentao Sun, Jingke Zhang, Hua Sui, Bing Li
Tanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate of Tan-IIA is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tan-IIA also has inhibitory effects on tumor cells such as gastric cancer, but its therapeutic effect and mechanism on human neuroblastoma have not been evaluated, so its pharmacological
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Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Chengjie Shu, Ling Ge, Zhuohang Li, Bin Chen, Shengliang Liao, Lu Lu, Qinlin Wu, Xinyi Jiang, Yuhan An, Zongde Wang, Man Qu
Background: Plant essential oils have long been regarded as repositories of antimicrobial agents. In recent years, they have emerged as potential alternatives or supplements to antimicrobial drugs. Although literature reviews and previous studies have indicated that cinnamon essential oil (CIEO) and its major component, cinnamaldehyde (CID), possess potent antibacterial activities, their antibacterial
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Sesquiterpene lactones as emerging biomolecules to cease cancer by targeting apoptosis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Chou-Yi Hsu, Sadegh Rajabi, Maryam Hamzeloo-Moghadam, Abhinav Kumar, Marc Maresca, Pallavi Ghildiyal
Apoptosis is a programmed cell death comprising two signaling cascades including the intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy response of different cancer types, making it an effective target for treating cancer. Cancer has been considered a challenging issue in global health. Cancer cells possess six biological characteristics during their developmental
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Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins inhibit intestinal glucose transport in human Caco-2 cells Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Mengting Wang, Haiguang Mao, Zhijian Ke, Jianchu Chen, Lili Qi, Jinbo Wang
Background: The hypoglycemic effects of Chinese bayberry leaves proanthocyanidins (BLPs) have been demonstrated. It is unclear, nevertheless, whether BLPs reduced postprandial blood glucose levels by regulating glucose uptake and glucose transport.Method: This study investigated the effect of BLPs (25, 50, and 100 μg/mL) on glucose uptake and glucose transport in human intestinal epithelial cells (Caco-2
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Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Purbali Chakraborty, Syeda Lubna, Shouvik Bhuin, Deepika K., Manab Chakravarty, Trinath Jamma, Perumal Yogeeswari
The pursuit of small molecule inhibitors targeting hexokinase 2 (HK2) has significantly captivated the field of cancer drug discovery. Nevertheless, the creation of selective inhibitors aimed at specific isoforms of hexokinase (HK) remains a formidable challenge. Here, we present a multiple-pharmacophore modeling approach for designing ligands against HK2 with a marked anti-proliferative effect on
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Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Jinpeng Zhang, Xinyuan Cui, Shuo Zhao, Zenghui Chang, Junshuo Zhang, Yufeng Chen, Jiale Liu, Guohao Sun, Yiyuan Wang, Yuanyuan Liu
Objective: Our previous studies substantiated that the biological activity of Schisandra chinensis lignans during the treatment of Alzheimer’s disease (AD) was mediated by neurotransmitter levels, and 15 of its active components were identified. However, the pharmacokinetic and pharmacodynamic relationship of Schisandra chinensis lignans has been less studied. The objective of this study was to investigate
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Unlocking the potential of fondaparinux: guideline for optimal usage and clinical suggestions (2023) Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Qinan Yin, Lizhu Han, Yin Wang, Fengjiao Kang, Fengqun Cai, Liuyun Wu, Xingyue Zheng, Lian Li, Li e Dong, Limei Dong, Shuhong Liang, Min Chen, Yong Yang, Yuan Bian
Background: Thromboembolic disease is associated with a high rate of disability or death and gravely jeopardizes people’s health and places considerable financial pressure on society. The primary treatment for thromboembolic illness is anticoagulant medication. Fondaparinux, a parenteral anticoagulant medicine, is still used but is confusing due to its disparate domestic and international indications
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Development and validation of a pharmacogenomics reporting workflow based on the illumina global screening array chip Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Pamela Gan, Muhammad Irfan Bin Hajis, Mazaya Yumna, Jessline Haruman, Husnul Khotimah Matoha, Dian Tri Wahyudi, Santha Silalahi, Dwi Rizky Oktariani, Fitria Dela, Tazkia Annisa, Tessalonika Damaris Ayu Pitaloka, Priscilla Klaresza Adhiwijaya, Rizqi Yanuar Pauzi, Robby Hertanto, Meutia Ayuputeri Kumaheri, Levana Sani, Astrid Irwanto, Ariel Pradipta, Kamonlawan Chomchopbun, Mar Gonzalez-Porta
Background: Microarrays are a well-established and widely adopted technology capable of interrogating hundreds of thousands of loci across the human genome. Combined with imputation to cover common variants not included in the chip design, they offer a cost-effective solution for large-scale genetic studies. Beyond research applications, this technology can be applied for testing pharmacogenomics,
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Pharmacological treatments and medication-related problems in nursing homes in Catalonia: a multidisciplinary approach Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-11 Emilie Anderssen-Nordahl, Margarita Sánchez-Arcilla Rosanas, Montserrat Bosch Ferrer, Mònica Sabaté Gallego, Eladio Fernández-Liz, Antonio San-José, Maria Estrella Barceló-Colomer
Background: Aging correlates with increased frailty, multi-morbidity, and chronic diseases. Furthermore, treating the aged often entails polypharmacy to achieve optimal disease management, augmenting medication-related problems (MRPs). Few guidelines and tools address the problem of polypharmacy and MRPs, mainly within the institutionalized elderly population. Routine pharmacological review is needed
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Gentiopicroside improves non-alcoholic steatohepatitis by activating PPARα and suppressing HIF1 Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-10 Chaoyuan Huang, Qiuhong Yong, Yihui Lu, Lu Wang, Yiyuan Zheng, Lina Zhao, Peiwu Li, Chong Peng, Wei Jia, Fengbin Liu
Gentiopicroside (GPS) is a highly water-soluble small-molecule drug and the main bioactive secoiridoid glycoside of Gentiana scabra that has been shown to have hepatoprotective effects against non-alcoholic steatohepatitis (NASH), a form of non-alcoholic fatty liver disease (NAFLD) that can progress to cirrhosis and hepatocellular carcinoma. However, the effects of GPS on NASH and the underlying mechanisms
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Dysregulation of sphingolipid metabolism in pain Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Jianfeng Wang, Guangda Zheng, Linfeng Wang, Linghan Meng, Juanxia Ren, Lu Shang, Dongtao Li, Yanju Bao
Pain is a clinical condition that is currently of great concern and is often caused by tissue or nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer. Severe pain seriously affects the functional status of the body. However, existing pain management programs are not fully satisfactory. Therefore, there is a need to delve deeper into the pathological mechanisms underlying
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Integrated chemical characterization, metabolite profiling, and pharmacokinetics analysis of Zhijun Tangshen Decoction by UPLC-Q/TOF-MS Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Qingheng Tong, Yueyue Chang, Guanxiong Shang, Jiu Yin, Xiaoqi Zhou, Suwei Wang, Xiaofeng Yan, Fangfang Zhang, Suqin Wang, Weifeng Yao
Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide and a major public issue affecting the health of people. Therefore, it is essential to explore effective drugs for the treatment of DN. In this study, the traditional Chinese medicine (TCM) formula, Zhijun Tangshen Decoction (ZJTSD), a prescription modified from the classical formula Didang Decoction, has been used in
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AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Mengnan Li, Limin Zhang, Jiahui Yu, Xiaoxiao Wang, Le Cheng, Zhaowu Ma, Xiaoguang Chen, Lingzhi Wang, Boon Cher Goh
Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as a pivotal enzyme in androgen biosynthesis. It catalyzes the conversion of weak androgens, estrone (a weak estrogen), and PGD2 into potent androgens (testosterone and 5α-dihydrotestosterone), 17β-estradiol (a potent estrogen), and 11β-PGF2α
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Efficacy and safety of levosimendan in patients with sepsis: a systematic review and network meta-analysis Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Ruimin Tan, He Guo, Zinan Yang, Huihui Yang, Qinghao Li, Qiong Zhu, Quansheng Du
Objective: We conducted a systematic review to assess the advantages and disadvantages of levosimendan in patients with sepsis compared with placebo, milrinone, and dobutamine and to explore the clinical efficacy of different concentrations of levosimendan.Methods: PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang data, VIP, and CBM databases were searched using such keywords as simendan
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Natural products reverse cancer multidrug resistance Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Jia-Yu Zou, Qi-Lei Chen, Xiao-Ci Luo, Davaadagva Damdinjav, Usama Ramadan Abdelmohsen, Hong-Yan Li, Tungalag Battulga, Hu-Biao Chen, Yu-Qing Wang, Jian-Ye Zhang
Cancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor MDR. Discovering novel potential modulators to reduce tumor MDR by Natural Product-Derived Compounds has become a popular research area across the globe
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The anti-cholestatic effects of Coptis chinensis Franch. alone and combined with Tetradium ruticarpum (A. Jussieu) T. G. Hartley: dual effects on fecal metabolism and microbial diversity Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Jun Han, Peijie Wu, Zongying Xu, Chao Liu, Qian Chen, Fenghua Zhang, Huan Tao, Dan Luo, Li Zhou, Bo Wang, Zhe Gao, Tao Shen, Yueqiang Wen, Han Yu
Introduction: Drug dosages and combinations are the main factors that affect the efficacy of pleiotropic traditional Chinese medicine (TCM). Coptis chinensis Franch. (CF) is a representative TCM with multiple effects and is often combined with Tetradium ruticarpum (A. Jussieu) T. G. Hartley (TR) to treat cholestasis. The present study assessed the influence of CF dose and its combination with TR on
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Clinical aspects of reimbursement policies for orphan drugs in Central and Eastern European countries Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Szczepan Jakubowski, Pawel Kawalec, Przemyslaw Holko, Iwona Kowalska-Bobko, Maria Kamusheva, Guenka Petrova, Pero Draganić, Leos Fuksa, Agnes Männik, Fanni Ispán, Vitalis Briedis, Ioana Bianchi, Marian Sorin Paveliu, Tomas Tesar
Objectives: The aim of this study was to characterize the reimbursement policy for orphan drugs (ODs) in Central and Eastern European (CEE) countries in relation to the availability and impact of clinical evidence, health technology assessment (HTA) procedure, selected economic indicators, and the drug type according to indications.Materials and methods: A list of authorized medicines with orphan designation
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Case report: Successful induction of buprenorphine in medically complex patients concurrently on opioids: a case series at a tertiary care center Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Thomas Shelton, Sharanya Nama, Orman Hall, Margaret Williams
Effective pain management is essential for optimal surgical outcomes; however, it can be challenging in patients with a history of opioid use disorder (OUD). Buprenorphine, a partial opioid agonist, is a valuable treatment option for patients with OUD. Initiating buprenorphine treatment in patients concurrently taking opioids can be complex due to potential adverse outcomes like precipitated withdrawal
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Anti-diabetic and anti-inflammatory bioactive hits from Coriaria intermedia Matsum. stem and Dracontomelon dao (Blanco) Merr. & Rolfe bark through bioassay-guided fractionation and liquid chromatography-tandem mass spectrometry Front. Pharmacol. (IF 5.6) Pub Date : 2024-03-08 Mavis Colleen Porciuncula Fabian, Rezzaira Marie Neduelan Astorga, Arnelson Arwin Gray Atis, Luis Agustin Elido Pilapil, Christine Chichioco Hernandez
Women have been found to be at a higher risk of morbidity and mortality from type 2 diabetes mellitus (T2DM) and asthma. α-Glucosidase inhibitors have been used to treat T2DM, and arachidonic acid 15-lipoxygenase (ALOX15) inhibitors have been suggested to be used as treatments for asthma and T2DM. Compounds that inhibit both enzymes may be studied as potential treatments for people with both T2DM and