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Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-03-08 Wanlu Ye, Nan Xiang, Qing Wang, Yanming Lu
Circular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various
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Identification of novel molecules and pathways associated with fascin actin‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-03-01 Hongliang Liu, Wenjing Hao, Xinfang Wang, Yuliang Zhang, Long He, Xuting Xue, Jiao Yang, Chunming Zhang
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells
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[Corrigendum] Bax inhibitor‑1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-03-01 Jiaxin Liu, Shuai Zhou, Yueting Zhang, Xiuying Li, Xiying Qian, Weihua Tao, Lide Jin, Jianhua Zhao
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors
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Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-03-01 Wenlin Yang, Yingze Wei, Ting Wang, Ying Xu, Xiaoxia Jin, Hongyan Qian, Shuyun Yang, Song He
SET domain bifurcated 1 (SETDB1), a pivotal histone lysine methyltransferase, is transported to the cytoplasm via a chromosome region maintenance 1 (CMR1)‑dependent pathway, contributing to non‑histone methylation. However, the function and underlying mechanism of cytoplasmic SETDB1 in breast cancer remain elusive. In the present study, immunohistochemistry revealed that elevated cytoplasmic SETDB1
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Adipocyte‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-03-01 Siqi Chen, Zixuan Liu, Haixia Wu, Bo Wang, Yuqing Ouyang, Junru Liu, Xiaoyan Zheng, Haoke Zhang, Xueying Li, Xiaofan Feng, Yan Li, Yangyang Shen, Hong Zhang, Bo Xiao, Chunyan Yu, Weimin Deng
The effects of adipocyte‑rich microenvironment (ARM) on chemoresistance have garnered increasing interest. Ovarian cancer (OVCA) is a representative adipocyte‑rich associated cancer. In the present study, epithelial OVCA (EOC) was used to investigate the influence of ARM on chemoresistance with the aim of identifying novel targets and developing novel strategies to reduce chemoresistance. Bioinformatics
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Protein aggregation and biomolecular condensation in hypoxic environments (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-02-16 Chaoqun Li, Bingjie Hao, Haiguang Yang, Kai Wang, Lihong Fan, Weihua Xiao
Due to molecular forces, biomacromolecules assemble into liquid condensates or solid aggregates, and their corresponding formation and dissolution processes are controlled. Protein homeostasis is disrupted by increasing age or environmental stress, leading to irreversible protein aggregation. Hypoxic pressure is an important factor in this process, and uncontrolled protein aggregation has been widely
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Research progress, challenges and perspectives of phospholipids metabolism in the LXR‑LPCAT3 signaling pathway and its relation to NAFLD (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-02-16 Junmin Wang, Jiacheng Li, Yugang Fu, Yingying Zhu, Liubing Lin, Yong Li
Phospholipids (PLs) are principle constituents of biofilms, with their fatty acyl chain composition significantly impacting the biophysical properties of membranes, thereby influencing biological processes. Recent studies have elucidated that fatty acyl chains, under the enzymatic action of lyso‑phosphatidyl‑choline acyltransferases (LPCATs), expedite incorporation into the sn‑2 site of phosphatidyl‑choline
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[Retracted] Long non‑coding RNA KCNQ1OT1 promotes nasopharyngeal carcinoma cell cisplatin resistance via the miR‑454/USP47 axis. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-02-09 Feng Yuan, Zhiping Lou, Zhifeng Zhou, Xiaojun Yan
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the colony formation assay data shown in Figs. 4C and 6D and the Transwell migration and invasion assay data shown in Figs. 4D, 6E and 6F were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had
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Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-02-01 Yifeng Zhang, Hang Yang, Shuai Hou, Yulei Xia, Yan-Qiang Wang
Stroke, a debilitating cerebrovascular ailment, poses significant threats to human life and health. The intricate interplay between the gut‑brain‑microbiota axis (GBMA) and cerebral ischemia‑reperfusion has increasingly become a focal point of scientific exploration, emerging as a pivotal research avenue in stroke pathophysiology. In the present review, the authors delved into the nexus between the
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A mid‑pandemic night's dream: Melatonin, from harbinger of anti‑inflammation to mitochondrial savior in acute and long COVID‑19 (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-02-01 Ioannis G Lempesis, Vasiliki Epameinondas Georgakopoulou, Russel J Reiter, Demetrios A Spandidos
Coronavirus disease 2019 (COVID‑19), a systemic illness caused by severe acute respiratory distress syndrome 2 (SARS‑CoV‑2), has triggered a worldwide pandemic with symptoms ranging from asymptomatic to chronic, affecting practically every organ. Melatonin, an ancient antioxidant found in all living organisms, has been suggested as a safe and effective therapeutic option for the treatment of SARS‑CoV‑2
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[Retracted] Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-02-01 Jing-Meng Hu, Li-Jie He, Peng-Bo Wang, Yan Yu, Ya-Ping Ye, Li Liang
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the EdU staining assay data shown in Figs. 4C and 5C and the western blotting data shown in Fig. 4E were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had either already been published, or were
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[Corrigendum] Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-01-26 Furong Song, Jun Liu, Yawei Feng, Yi Jin
Following the publication of the above article, an interested reader drew to the authors' attention that the western blots for the PCNA and cyclin D1 bands appeared to be strikingly similar. The authors were able to re‑examine their original data, and recognize how the error was made with respect to the compilation of this figure (they were also able to demonstrate to the Editorial Office how the error
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NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-01-19 Hong Zhou, Qun Zhang, Chenyang Liu, Jiahao Fan, Wen Huang, Nan Li, Mingxia Yang, Hong Wang, Weiping Xie, Hui Kong
NOD-like receptor protein 3 (NLRP3) inflammasome is closely related to silica particle‑induced chronic lung inflammation but its role in epithelial remodeling, repair and regeneration in the distal lung during development of silicosis remains to be elucidated. The present study aimed to determine the effects of the NLRP3 inflammasome on epithelial remodeling and cellular regeneration and potential
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[Retracted] MicroRNA‑15a‑5p‑targeting oncogene YAP1 inhibits cell viability and induces cell apoptosis in cervical cancer cells. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-01-19 Xu Chen, Ruiqin Cao, Haifang Liu, Tuanying Zhang, Xinrong Yuan, Shuxiang Xu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion assay data shown in Fig. 3A and B on p. 1306 were strikingly similar to data appearing in different form in a paper by different authors at a different research institute that had already been submitted for publication. Owing to the fact that the contentious data
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Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-01-19 Xinwang Zhu, Congxiao Zhang, Linlin Liu, Li Xu, Li Yao
The senolytics dasatinib and quercetin (DQ) alleviate age‑related disorders. However, limited information is available regarding the effects of DQ on diabetic kidney disease (DKD). The present study aimed to explore the effects of DQ on DKD and its potential molecular mechanism(s). Dasatinib (5 mg/kg) and quercetin (50 mg/kg) were administered to diabetic db/db mice by gavage for 20 weeks. Body weight
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Low‑intensity pulsed ultrasound accelerates diabetic wound healing by ADSC‑derived exosomes via promoting the uptake of exosomes and enhancing angiogenesis. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-01-12 Fanglu Zhong, Sheng Cao, Li Yang, Junbi Liu, Bin Gui, Hao Wang, Nan Jiang, Qing Zhou, Qing Deng
Diabetic wounds remain a great challenge for clinicians globally as a lack of effective radical treatment often results in poor prognosis. Exosomes derived from adipose‑derived stem cells (ADSC‑Exos) have been explored as an appealing nanodrug delivery system in the treatment of diabetic wounds. However, the short half‑life and low utilization efficiency of exosomes limit their therapeutic effects
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Regulator of G protein signalling 18 promotes osteocyte proliferation by activating the extracellular signal‑regulated kinase signalling pathway. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-01-12 Yong Meng, Si-Qiang Qiu, Qiang Wang, Jin-Liang Zuo
Osteocyte function is critical for metabolism, remodelling and regeneration of bone tissue. In the present study, the roles of regulator of G protein signalling 18 (RGS18) were assessed in the regulation of osteocyte proliferation and bone formation. Target genes and signalling pathways were screened using the Gene Expression Omnibus (GEO) database and Gene Set Enrichment Analysis (GSEA). The function
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[Retracted] Upregulation of miR‑183‑5p is responsible for the promotion of apoptosis and inhibition of the epithelial‑mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin. Int. J. Mol. Med. (IF 5.4) Pub Date : 2024-01-12 Hua Yan, Bing-Mei Sun, Yu-Ying Zhang, Yu-Juan Li, Cheng-Xiang Huang, Fu-Zhong Feng, Cui Li
Following the publication of this article, a concerned reader drew to the Editor's attention that, in Fig. 9C on p. 2478 showing the results of Transwell invasion assay experiments, unexpected areas of similarity were identified in terms of the cellular patterns revealed both within the data panels for the six different experiments portrayed in this figure, and comparing among them. After having conducted
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Deciphering the emerging landscape of HOX genes in cardiovascular biology, atherosclerosis and beyond (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-22 Yu Zhou, Qiang Wu, Yingchu Guo
Atherosclerosis, a dominant driving force underlying multiple cardiovascular events, is an intertwined and chronic inflammatory disease characterized by lipid deposition in the arterial wall, which leads to diverse cardiovascular problems. Despite unprecedented advances in understanding the pathogenesis of atherosclerosis and the substantial decline in cardiovascular mortality, atherosclerotic cardiovascular
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[Retracted] Rotenone restrains colon cancer cell viability, motility and epithelial‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-15 Wenbo Xiao, Yongwei Liu, Maolin Dai, Yu Li, Renqun Peng, Shuangjiang Yu, Hao Liu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the immunofluorescence staining data shown in Fig. 3C, and the migration and invasion assay data shown in Figs. 4C and 4D were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had either already
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An LGR4 agonist activates the GSK‑3β pathway to inhibit RANK‑RANKL signaling during osteoclastogenesis in bone marrow‑derived macrophages. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Yuria Jang, Hyeonjoon Lee, Yongjin Cho, Eunseo Choi, Suenghwan Jo, Hong Moon Sohn, Beom Chang Kim, Young Jong Ko, Wonbong Lim
The binding between receptor‑activated nuclear factor‑κB (RANK) and the RANK ligand (RANKL) during osteoclast development is an important target for drugs that treat osteoporosis. The leucine‑rich repeat‑containing G‑protein‑coupled receptor 4 (LGR4) acts as a negative regulator of RANK‑RANKL that suppresses canonical RANK signaling during osteoclast differentiation. Therefore, LGR4 agonists may be
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Euphorbia factor L2 suppresses the generation of liver metastatic ascites in breast cancer via inhibiting NLRP3 inflammasome activation. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Dongjing Jiang, Xun Liu, Rulan Tan, Ye Zhu, Li Zhang
Metastasis is the leading cause of death in patients with breast cancer, in part due to the lack of effective treatments. Euphorbia factor L2 (EFL2) is a diterpenoid extracted from Euphorbia lathyris L. seeds, which has attracted increasing attention in recent years due to its anticancer effect. However, the role and molecular mechanism of EFL2 in breast cancer liver metastasis remain unclear. In the
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Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Zhenkai Ma, Hui Lu, Xuemin Feng, Ting Du, Jianhua Li, Qiang Zhang, Xindong Gu, Yuandong Shao, Xingzhi Jing, Cheng Su
Iron overload and ferroptosis are associated with intervertebral disc degeneration (IDD); however, the mechanism underlying the regulation of iron homeostasis remains to be elucidated. Nuclear factor erythroid 2‑related factor 2 (Nrf2) has been reported to regulate cellular iron homeostasis; however, its impact on IDD pathology and the underlying mechanism of action requires further investigation.
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Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Miaomiao Xu, Ying Cui, Siyuan Wei, Xuelong Cong, Yiying Chen, Shujie Tian, Anqi Yao, Weiwei Chen, Lixing Weng
Macrophages, as highly heterogeneous and plastic immune cells, occupy a pivotal role in both pro‑inflammatory (M1) and anti‑inflammatory (M2) responses. While M1‑type macrophages secrete pro‑inflammatory factors to initiate and sustain inflammation, M2‑type macrophages promote inflammation regression and uphold tissue homeostasis. These distinct phenotypic transitions in macrophages are closely linked
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Role of vitamins beyond vitamin D3 in bone health and osteoporosis (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Anatoly V Skalny, Michael Aschner, Aristidis Tsatsakis, Joao B T Rocha, Abel Santamaria, Demetrios A Spandidos, Airton C Martins, Rongzhu Lu, Tatiana V Korobeinikova, Wen Chen, Jung-Su Chang, Jane C J Chao, Chong Li, Alexey A Tinkov
The objective of the present review was to summarize the molecular mechanisms associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and their potential roles in the development of osteoporosis. Epidemiological findings have demonstrated an association between vitamin deficiency and a higher risk of developing osteoporosis; vitamins are positively related to bone health
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Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Sangyu Hu, Zhigang Li, Huan Liu, Wenze Cao, Yilei Meng, Chang Liu, Siyu He, Qin Lin, Mengyue Shang, Fang Lin, Na Yi, Hanrui Wang, Agapios Sachinidis, Qilong Ying, Li Li, Luying Peng
The Kv11.1 potassium channel encoded by the Kcnh2 gene is crucial in conducting the rapid delayed rectifier K+ current in cardiomyocytes. Homozygous mutation in Kcnh2 is embryonically lethal in humans and mice. However, the molecular signaling pathway of intrauterine fetal loss is unclear. The present study generated a Kcnh2 knockout rat based on edited rat embryonic stem cells (rESCs). Kcnh2 knockout
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[Retracted] Downregulation of ROS‑FIG inhibits cell proliferation, colony‑formation, cell cycle progression, migration and invasion, while inducing apoptosis in intrahepatic cholangiocarcinoma cells. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Gang Deng, Chenghuan Hu, Lei Zhu, Feizhou Huang, Wei Huang, Hongbo Xu, Wanpin Nie
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 9 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to International Journal
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Nanobodies in cytokine‑mediated immunotherapy and immunoimaging (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-08 Xiaochen Zhang, Jin Wang, Ying Tan, Chaoting Chen, Shuang Tang, Shimei Zhao, Qiuhong Qin, Hansheng Huang, Siliang Duan
Cytokines are the main regulators of innate and adaptive immunity, mediating communications between the cells of the immune system and regulating biological functions, including cell motility, differentiation, growth and apoptosis. Cytokines and cytokine receptors have been used in the treatment of tumors and autoimmune diseases, and to intervene in cytokine storms. Indeed, the use of monoclonal antibodies
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Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-12-01 Zuly A Sánchez-Florentino,Bianca S Romero-Martínez,Edgar Flores-Soto,Héctor Serrano,Luis M Montaño,Marcela Valdés-Tovar,Eduardo Calixto,Arnoldo Aquino-Gálvez,Germán O López-Riquelme,Ramón Alvarado,Jesús Argueta,Héctor Solís-Chagoyán,Bettina Sommer
Schizophrenia (SZ) is a multifactorial disorder characterized by volume reduction in gray and white matter, oxidative stress, neuroinflammation, altered neurotransmission, as well as molecular deficiencies such as punctual mutation in Disrupted‑in‑Schizophrenia 1 protein. In this regard, it is essential to understand the underlying molecular disturbances to determine the pathophysiological mechanisms
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Inhibition of HDAC6 alleviates cancer‑induced bone pain by reducing the activation of NLRP3 inflammasome. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-11-24 Yin-Di Hu, Zhao-Di Wang, Yuan-Fen Yue, Dai Li, Shu-Qing Zhen, Jie-Qiong Ding, Wei Meng, Hai-Li Zhu, Min Xie, Ling Liu
Cancer‑induced bone pain (CIBP) is characterized as moderate to severe pain that negatively affects the daily functional status and quality of life of patients. When cancer cells metastasize and grow in bone marrow, this activates neuroinflammation in the spinal cord, which plays a vital role in the generation and persistence of chronic pain. In the present study, a model of CIBP was constructed by
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mROS‑calcium feedback loop promotes lethal ventricular arrhythmias and sudden cardiac death in early myocardial ischemia. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-11-24 Danya Zhou, Ye Zhang, Mengting Zhu, Xiaojun Zhang, Xiaojuan Zhang, Junyao Lv, Wanting Tang, Qi Weng, Yang Lin, Lejun Tong, Zhiwei Zhong, Yanmei Zhang, Mengxuan Zhang, Minchao Lai, Dian Wang
Lethal ventricular arrhythmia‑sudden cardiac death (LVA‑SCD) occurs frequently during the early stage of myocardial ischemia (MI). However, the mechanism underlying higher LVA‑SCD incidence is still poorly understood. The present study aimed to explore the role of mitochondrial reactive oxygen species (mROS) and Ca2+ crosstalk in promoting LVA‑SCD in early MI. RyR2 S2814A mice and their wild‑type littermates
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Roles of vitamin K‑dependent protein in biomineralization (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-11-24 Meng Zhang, Qingqi Zhang, Pengfei Du, Xin Chen, Yumei Zhang
Vitamin K (VK), a fat‑soluble vitamin, is well known as an anticoagulant in the clinic. It is essential for the post‑translational activation of VK‑dependent proteins (VKDPs) because hydroquinone VK is a cofactor of glutamine carboxylase. At present, 17 VKDPs are known, which are mainly involved in coagulation and calcification. When Glu residues are carboxylated to Gla residues, these proteins gain
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[Retracted] Downregulation of long non‑coding RNA GACAT1 suppresses proliferation and induces apoptosis of NSCLC cells by sponging microRNA‑422a. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-11-08 Youqing Zhong, Hui Lin, Qi Li, Chang Liu, Lei Zhong
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the flow cytometric data shown in Fig. 2E on p. 662 were strikingly similar to data appearing in different form in a pair of other research articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been
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Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-11-08 Xuehan Gao, Runying Long, Ming Qin, Wenfang Zhu, Linna Wei, Pinzhi Dong, Jin Chen, Junmin Luo, Jihong Feng
Tumor‑associated macrophages (TAMs) are pivotal components in colorectal cancer (CRC) progression, markedly influencing the tumor microenvironment through their polarization into the pro‑inflammatory M1 or pro‑tumorigenic M2 phenotypes. Recent studies have highlighted that the Grb2‑associated binder 2 (Gab2) is a critical gene involved in the development of various types of tumor, including CRC. However
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Single‑cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-11-08 Dunyong Tan, Zeqi Huang, Zhe Zhao, Xiaoqiang Chen, Jianquan Liu, Daping Wang, Zhiqin Deng, Wencui Li
Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration, secondary bone hyperplasia, inadequate extracellular matrix synthesis and degeneration of articular cartilage. Mesenchymal stem cells (MSCs) can self‑renew and undergo multidirectional differentiation; they can differentiate into chondrocytes. Aging MSCs have a weakened ability to differentiate, and release
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Bone marrow mesenchymal stem cell‑derived exosomes: A novel therapeutic agent for tendon‑bone healing (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-11-08 Yongjia Zhu, Jiapeng Yan, Hongfei Zhang, Guanxing Cui
In sports medicine, injuries related to the insertion of tendons into bones, including rotator cuff injuries, anterior cruciate ligament injuries and Achilles tendon ruptures, are commonly observed. However, traditional therapies have proven to be insufficient in achieving satisfactory outcomes due to the intricate anatomical structure associated with these injuries. Adult bone marrow mesenchymal stem
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Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoaging. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-27 A Yeon Park, Jung Ok Lee, Youna Jang, Yu-Jin Kim, Jung Min Lee, Su-Young Kim, Beom Joon Kim, Kwang Ho Yoo
Exosomes are used as innovative treatment options for repairing skin defects, such as aging, atopic dermatitis and wounds. However, the effects of exosomes obtained from human foreskin fibroblasts BJ‑5ta (BJ‑5ta Exo) on ultraviolet B (UVB)‑mediated photoaging have not been previously reported, at least to the best of our knowledge. Therefore, the present study aimed to investigate the anti‑photoaging
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Potential mechanism of TMEM2/CD44 in endoplasmic reticulum stress‑induced neuronal apoptosis in a rat model of traumatic brain injury. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-27 Muyao Wu, Chaoyu Wang, Yating Gong, Yaqian Huang, Lei Jiang, Min Zhang, Rong Gao, Baoqi Dang
Traumatic brain injury (TBI) can lead to the disruption of endoplasmic reticulum (ER) homeostasis in neurons and induce ER stress. Transmembrane protein 2 (TMEM2) may regulate ER stress through the p38/ERK signaling pathway, independent of the classic unfolded protein response (UPR) pathway. The present study examined the expression of TMEM2 following TBI in a rat model, in an aim to determine whether
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Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-27 Shihua Deng, Jin Li, Li Li, Sheng Lin, Yueyan Yang, Teng Liu, Ting Zhang, Guangsu Xie, Dongming Wu, Ying Xu
Acute lung injury (ALI) causes high morbidity and mortality rates in critically ill patients, and there are currently no effective therapeutic drugs. Ferroptosis is a newly discovered mode of regulated cell death that contributes to the progression of ALI. Quercetin possesses anti‑inflammatory and antioxidant properties. However, whether quercetin can protect against lipopolysaccharide (LPS)‑induced
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Role of dendritic cell‑derived exosomes in allergic rhinitis (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-27 Chenglin Kang, Haipeng He, Peng Liu, Yue Liu, Xiaomei Li, Jin Zhang, Hong Ran, Xianhai Zeng, Hailiang Zhao, Jiangqi Liu, Shuqi Qiu
Allergic rhinitis (AR) is a common pathological condition in otorhinolaryngology. Its prevalence has been increasing worldwide and is becoming a major burden to the world population. Dendritic cells (DCs) are typically activated and matured after capturing, phagocytosing, and processing allergens during the immunopathogenesis of AR. In addition, the process of DC activation and maturation is accompanied
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Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-20 Xin Lin,Xiaoxia Zhao,Qingfeng Chen,Xiaoyue Wang,Yongya Wu,Hao Zhao
Sepsis‑induced cardiomyopathy (SIC) is a manifestation of multiple organ failure as a result of sepsis and is a serious threat to life. Here, the effect and mechanisms of quercetin (QUE) in SIC were assessed. It was found that patients with SIC expressed lower serum levels of glutathione peroxidase 4 (GPX4) and SIRT1 but higher levels of CK‑MB, cTnI, TNF‑α, and IL‑6 compared with healthy individuals
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Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer's disease. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-13 Jing He, Yuanjie Liu, Junhua Li, Yueyang Zhao, Hanxiao Jiang, Shifang Luo, Guiqiong He
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid‑β (Aβ) in the brain. The gut/brain axis may serve a role in AD pathogenesis. The present study investigated deposition of Aβ in the intestinal epithelium and its potential effects on intestinal barrier function in a transgenic mouse model of AD. To investigate alterations in the structure and functionality
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[Corrigendum] Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P‑gp and MRP‑1. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-13 Ying-Jie Yi, Xiu-Hong Jia, Jian-Yong Wang, You-Jie Li, Hong Wang, Shu-Yang Xie
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 2 on p. 1408, the microscopic images shown for the light scope images (upper row) and the green fluorescence images (lower row) appeared to be overlapping, such that these images appeared to have been derived from the same original sources even though they were intended to portray the results
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Piperlongumine induces apoptosis via the MAPK pathway and ERK‑mediated autophagy in human melanoma cells. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-13 Su-Ji Jeon, Eun-Young Choi, Eun-Ji Han, Sang-Woo Lee, Jun-Mo Moon, Soo-Hyun Jung, Ji-Youn Jung
Piperlongumine (PL) is an amide alkaloid with diverse pharmacological effects against cancer, bronchitis and asthma; however, research on its efficacy against melanoma is lacking. The present study investigated the anticancer effects of PL on A375SM and A375P human melanoma cells. PL decreased the survival rate of A375SM and A375P cells, as shown by MTT assay, increase of apoptotic cells by DAPI staining
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Spotlight on HOX cluster‑embedded antisense lncRNAs in cardiovascular diseases (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-13 Yu Zhou, Qiang Wu
Atherosclerosis is a complex and chronic inflammatory disease driven by multiple pathophysiological processes that are responsible for diverse cardiovascular events. Atherosclerotic cardiovascular disease, despite substantial triumphs in primary and secondary prevention, remains a dominant epidemic that impairs human health. Therefore, deciphering the pathogenesis of atherosclerosis will provide a
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Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-06 Longfei Wang, Hongchu Zha, Jing Huang, Lang Shi
In the follow‑up of hospitalized patients with acute kidney injury (AKI), it has been observed that 15‑30% of these patients progress to develop chronic kidney disease (CKD). Impaired adaptive repair of the kidneys following AKI is a fundamental pathophysiological mechanism underlying renal fibrosis and the progression to CKD. Deficient repair of proximal tubular epithelial cells is a key factor in
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Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-06 Tie Hu, Hua-Xi Zou, Shu-Yu Le, Ya-Ru Wang, Ya-Mei Qiao, Yong Yuan, Ji-Chun Liu, Song-Qing Lai, Huang Huang
Tanshinone IIA (TSN) extracted from danshen (Salvia miltiorrhiza) could protect cardiomyocytes against myocardial ischemia/reperfusion injury (IRI), however the underlying molecular mechanisms of action remain unclear. The aim of the present study was to identify the protective effects of TSN and its mechanisms of action through in vitro studies. An anoxia/reoxygenation (A/R) injury model was established
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Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-06 Yujia Zheng, Xiaolu Zhang, Ruifeng Zhang, Ziyu Wang, Jiali Gan, Qing Gao, Lin Yang, Pengjuan Xu, Xijuan Jiang
The intricate nature of Alzheimer's disease (AD) pathogenesis poses a persistent obstacle to drug development. In recent times, neuroinflammation has emerged as a crucial pathogenic mechanism of AD, and the targeting of inflammation has become a viable approach for the prevention and management of AD. The present study conducted a comprehensive review of the literature between October 2012 and October
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Arctiin attenuates iron overload‑induced osteoporosis by regulating the PI3K/Akt pathway. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-10-06 Miao Li, Zhaofeng Pan, Qi He, Jiacong Xiao, Baihao Chen, Fanchen Wang, Pan Kang, Haoran Luo, Jianliang Li, Jiaxu Zeng, Shaocong Li, Junzheng Yang, Haibin Wang, Chi Zhou
Iron overload is a prevalent pathological factor observed among elderly individuals and those with specific hematological disorders, and is frequently associated with an elevated incidence of osteoporosis. Although arctiin (ARC) has been shown to possess antioxidant properties and the ability to mitigate bone degeneration, its mechanism of action in the treatment of iron overload‑induced osteoporosis
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Secretome of EMSCs neutralizes LPS‑induced acute lung injury via aerosol administration. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-29 Jianing Tan, Ziliang Zhuo, Xiuyu Wang, Yanshuang Zhang, Yucheng Qian, Fangfang Lin
Ectodermal mesenchymal stem cells (EMSCs) are cells harvested from the stem cell niche (nasal mucosa) with high therapeutic potential. To the best of our knowledge, however, the anti‑inflammatory properties of these neural crest‑derived EMSCs have been rarely reported. The present study aimed to explore the effects of aerosolized EMSC‑Secretome (EMSC‑Sec) and clarify underlying mechanisms in treating
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Curculigoside mitigates dextran sulfate sodium‑induced colitis by activation of KEAP1‑NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-29 Fang Li, Hua Huang, Ping Zhao, Jie Jiang, Xufeng Ding, Donxgue Lu, Lijiang Ji
Curculigoside (CUR), a primary active ingredient of Curculigo orchioides Gaertn, serves an important role in the intervention of numerous diseases, including ulcerative colitis, rheumatoid arthritis, myocardial ischemia, etc. However its specific mechanisms of therapy have not been fully elucidated. The aim of the present study was to elucidate the mechanisms underlying the anti‑oxidative stress and
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[Corrigendum] Melanogenesis in uveal melanoma cells: Effect of argan oil. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-29 Nunzia Caporarello, Melania Olivieri, Martina Cristaldi, Dario Rusciano, Gabriella Lupo, Carmelina Daniela Anfuso
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 7 on p. 1282, a pair of the western blotting bands in the Akt blot positioned adjacent to each other looked strikingly similar. Although the authors considered that the data were correct as shown (and the Editorial Office were in agreement that it was not certain that the bands were identical)
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The role of heat shock proteins in the pathogenesis of heart failure (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-29 Anastasia Pavlovna Sklifasovskaya, Mikhail Blagonravov, Anna Ryabinina, Vyacheslav Goryachev, Sergey Syatkin, Sergey Chibisov, Karina Akhmetova, Daniil Prokofiev, Enzo Agostinelli
The influence of heat shock proteins (HSPs) on protein quality control systems in cardiomyocytes is currently under investigation. The effect of HSPs on the regulated cell death of cardiomyocytes (CMCs) is of great importance, since they play a major role in the implementation of compensatory and adaptive mechanisms in the event of cardiac damage. HSPs mediate a number of mechanisms that activate the
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Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia‑1. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-15 Hyun-Ju Yu,Ji-Ae Shin,Su-Jung Choi,Sung-Dae Cho
Podophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects
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UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF‑1α‑mediated mitophagy. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-08 Qiqian Yan, Shanwei Shi, Yang Ge, Shuangquan Wan, Mingfei Li, Maoquan Li
Stem cell‑based tissue engineering has shown significant potential for rapid restoration of injured cartilage tissues. Stem cells frequently undergo apoptosis because of the prevalence of oxidative stress and inflammation in the microenvironment at the sites of injury. Our previous study demonstrated that stabilization of hypoxia‑inducible factor 1α (HIF‑1α) is key to resisting apoptosis in chondrocytes
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Role of transcription factor FOXM1 in diabetes and its complications (Review). Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-08 Baoqing Zhao, Mengxi Li, Yanting Su, Shigang Shan, Wenbin Qian, Dan Zhu, Xiufen Liu, Zhenwang Zhang
Diabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes
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[Corrigendum] Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-08 Jian Du, Bo Tang, Jingwen Wang, Hongtao Sui, Xueli Jin, Liming Wang, Zhongyu Wang
Following the publication of the above article, an interested reader drew to the authors' attention that, for the western blots shown in Fig. 4 on p. 610, the two leftmost bands shown for the Bax data in Fig. 4A were strikingly similar to the two rightmost Mito Cyt C bands featured in Fig. 4C. The authors have checked their original data, and realized that these data were assembled incorrectly in this
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Characterization of circRNAs in established osimertinib‑resistant non‑small cell lung cancer cell lines. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-08 Xin Chen, Jingyao Gu, Jiali Huang, Kang Wen, Ge Zhang, Zhenyao Chen, Zhaoxia Wang
Drug resistance is an urgent problem to be solved in the treatment of non‑small‑cell lung cancer (NSCLC). Osimertinib is a third‑generation EGFR‑tyrosine kinase inhibitor, which can improve the efficacy and quality of life of patients; however, the inevitable resistance after long‑term use of osimertinib often leads to treatment failure. Cell lines are key tools for basic and preclinical studies. At
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Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1α/NOD1/NF‑κB pathway. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-01 Lihua Hu, Chaoqun Xu, Xiang Tang, Shanjun Yu, Lijun Wang, Qi Li, Xiangdong Zhou
Fine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for
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Adropin attenuates pancreatitis‑associated lung injury through PPARγ phosphorylation‑related macrophage polarization. Int. J. Mol. Med. (IF 5.4) Pub Date : 2023-09-01 Fadian Ding, Guozhong Liu, Feng Gao, Zhou Zheng, Yupu Hong, Youting Chen, Shangeng Weng
Acute pancreatitis (AP)‑associated lung injury (ALI) is a critical complication of AP. Adropin is a regulatory protein of immune metabolism. The present study aimed to explore the immunomodulatory effects of adropin on AP‑ALI. For this purpose, serum samples of patients with AP were collected and the expression levels of serum adropin were detected using ELISA. Animal models of AP and adropin knockout