-
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-03-05 Tove Selvin, Malin Berglund, Lena Lenhammar, Magnus Lindskog, Malin Jarvius, Rolf Larsson, Peter Nygren, Mårten Fryknäs, Claes R Andersson
It has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunological effects of 46 standard anticancer agents and 22 commonly administered concomitant non-cancer drugs. We utilized a miniaturized in vitro model system comprised of fluorescently labeled human
-
Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-03-05 Han-Jie Lin, Pin-Yang Shih, Stella Chin-Shaw Tsai, Wu-Lung Chuang, Tsai-Ling Hsieh, Heng-Jun Lin, Teng-Shun Yu, Fuu-Jen Tsai, Chiu-Ying Chen, Kuang-Hsi Chang
This study aimed to evaluate the long-term risk of CKD and renal function declines using a combination of diuretics and SGLT2i. We selected the data of subjects who had at least two outpatient records or at least one inpatient record for DM treatment as the DM group from the National Health Insurance Research Database (NHIRD). Patients receiving versus not receiving SGLT2i were defined as the SGLT2i
-
Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-27 Xu Zuo, Xin Zhao, Jinjin Shi, Tiandong Zhang
This bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into two groups and received a single dose (sulfamethoxazole: 400 mg and trimethoprim: 80 mg) of test cotrimoxazole tablets (generic drug) or reference cotrimoxazole tablets (branded drug). After a
-
Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-27 Salwa Farid Ahmed, Eman M. F. El-Maghraby, Maha M. Rashad, Dina W. Bashir
Radiation triggers salivary gland damage and excess iron accumulates in tissues induces cell injury. Flavonoids are found in some fruits and are utilized as potent antioxidants and radioprotective agents. This study aimed to evaluate the antioxidant and anti-inflammatory effects of hesperidin and rutin on gamma radiation and iron overload induced submandibular gland (SMG) damage and to evaluate their
-
Preparation and evaluation of transdermal permeation of Huperzine A ethosomes gel in vitro BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-26 Jiyu Wu, Renai Xu, Xiaowei Xu, Shiyuan Ye, Aifang Huang
This study aimed to design and evaluate the transdermal permeation of Huperzine A ethosomes gel in vitro. Huperzine A ethosomes were prepared using the injection method, and their physical and chemical properties were characterized. A comparison was made between Huperzine A ethosomes gel, ordinary gel, and cream. The Franz diffusion cell test on mouse abdominal skin was conducted, and Huperzine A concentration
-
Pharmacovigilance study of BCR-ABL1 tyrosine kinase inhibitors: a safety analysis of the FDA adverse event reporting system BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-23 Dehua Zhao, Xiaoqing Long, Jisheng Wang
With the increased use of BCR-ABL1 tyrosine kinase inhibitors (TKIs) in cancer patients, adverse events (AEs) have garnered considerable interest. We conducted this pharmacovigilance study to evaluate the AEs of BCR-ABL1 TKIs in cancer patients using the Food and Drug Administration Adverse Event Reporting System (FAERS) database. To query AE reports from the FAERS database, we used OpenVigil 2.1.
-
The effect of oral supplementation of Paricalcitol on C-reactive protein levels in chronic kidney disease patients: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-23 Seyyed Mostafa Arabi, Mostafa Shahraki-Jazinaki, Mahla Chambari, Leila Sadat Bahrami, Sara Sabeti, Mohammaed Ibrahim Mohaildeen Gubari, Basil D. Roufogalis, Amirhossein Sahebkar
Previous studies investigating the effect of oral supplementation of paricalcitol on reactive protein levels in chronic kidney disease (CKD) patients reported inconsistent findings. In this systematic review and meta-analysis, we have analyzed and interpreted the results obtained from previous randomized clinical trials on the effect of paricalcitol on C-reactive protein in CKD patients in the literature
-
New tricks for old drugs- praziquantel ameliorates bleomycin-induced pulmonary fibrosis in mice BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-14 Yanjun Zeng, Rui Hu, Wei Ma, Ying Ding, Yi Zhou, Xin Peng, Lixin Feng, Qingmei Cheng, Ziqiang Luo
Pulmonary fibrosis is a chronic progressive disease with complex pathogenesis, short median survival time, and high mortality. There are few effective drugs approved for pulmonary fibrosis treatment. This study aimed to evaluate the effect of praziquantel (PZQ) on bleomycin (BLM)-induced pulmonary fibrosis. In this study, we investigated the role and mechanisms of PZQ in pulmonary fibrosis in a murine
-
Safinamide, an inhibitor of monoamine oxidase, modulates the magnitude, gating, and hysteresis of sodium ion current BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-08 Te-Yu Hung, Sheng-Nan Wu, Chin-Wei Huang
Safinamide (SAF), an α-aminoamide derivative and a selective, reversible monoamine oxidase (MAO)-B inhibitor, has both dopaminergic and nondopaminergic (glutamatergic) properties. Several studies have explored the potential of SAF against various neurological disorders; however, to what extent SAF modulates the magnitude, gating, and voltage-dependent hysteresis [Hys(V)] of ionic currents remains unknown
-
Large variation in anti-factor Xa levels with nadroparin as thromboprophylaxis in COVID-19 and non-COVID-19 critically ill patients BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-06 Monique M.R. de Maat, Henk J. van Leeuwen, Lian Roovers, Sabine J.G.M. Ahlers, Jolanda Lambers, Marcel M.C. Hovens
Critically ill COVID-19 and non-COVID-19 patients receive thromboprophylaxis with the LMWH nadroparin. Whether a standard dosage is adequate in attaining the target anti-FXa levels (0.20–0.50 IU/ml) in these groups is unknown. This study was a prospective, observational study in the ICU of a large general teaching hospital in the Netherlands. COVID-19 and non-COVID-19 patients admitted to the ICU who
-
Determination of the median lethal dose of zinc gluconate in mice and safety evaluation BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-05 Yong-cai Wang, Xia Yang, Juan Xiao, Su-mei Wei, Ying Su, Xiu-qi Chen, Ting Huang, Qing-wen Shan
Zinc Gluconate (ZG) is a safe and effective supplement for zinc. However, there is limited research on the optimal dosage for intravenous injection and the safety evaluation of animal models for ZG. This study aims to determine the safe dose range of ZG for intravenous injection in C57BL/6J mice. A Dose titration experiment was conducted to determine the LD50 and 95% confidence interval (95%CI) of
-
Role of uranium toxicity and uranium-induced oxidative stress in advancing kidney injury and endothelial inflammation in rats BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-02 Yuwei Yang, Chunmei Dai, Xi Chen, Bin Zhang, Xiaohan Li, Wenyu Yang, Jun Wang, Jiafu Feng
Uranium exposure may cause serious pathological injury to the body, which is attributed to oxidative stress and inflammation. However, the pathogenesis of uranium toxicity has not been clarified. Here, we evaluated the level of oxidative stress to determine the relationship between uranium exposure, nephrotoxic oxidative stress, and endothelial inflammation. Forty male Sprague–Dawley rats were divided
-
Drug-drug interaction assessment based on a large-scale spontaneous reporting system for hepato- and renal-toxicity, and thrombocytopenia with concomitant low-dose methotrexate and analgesics use BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-02-01 Takeshi Honma, Kenji Onda, Koichi Masuyama
Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) treatment and is highly effective with low-dose intermittent administration. MTX is occasionally used in combination with non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (APAP)/paracetamol for pain or inflammation control. With MTX treatment, the side effects, such as hepatotoxicity, renal failure, and myelosuppression
-
Comparison of three different prophylactic treatments for postoperative nausea and vomiting after total joint arthroplasty under general anesthesia: a randomized clinical trial BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-30 Jinwei Xie, Yingcun Cai, Fuxing Pei
Postoperative nausea and vomiting (PONV) after total joint arthroplasty is common and associated with delayed recovery. This study was performed to evaluate the efficacy of three different prophylactic regimens for PONV after total joint arthroplasty under general anesthesia. Patients undergoing primary total hip or knee arthroplasty were randomized to Group A (ondansetron), Group B (10 mg dexamethasone
-
Informal sale of antibiotics in Guatemalan convenience stores before and after implementation of federal antibiotic dispensing legislation BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-25 N. Rojop, P. Moreno, L. Grajeda, J. Romero, L. Reynoso, E. Muñoz, G. H. Palmer, C. Cordón-Rosales, D. R. Call, B. M. Ramay
Convenience stores in Guatemala provide essential consumer goods in communities, but many dispense antibiotics illegally. Federal legislation, passed in August of 2019, requires prescriptions for antibiotic purchase at pharmacies but it is unclear if this legislation is enforced or if it has any impact on unlawful sales of antibiotics. To determine if antibiotic availability changed in convenience
-
Lipidomics reveals serum lipid metabolism disorders in CTD-induced liver injury BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-15 Shan Li, Xiaotong Duan, Yixin Zhang, Cancan Zhao, Ming Yu, Xiaofei Li, Xiaomei Li, Jianyong Zhang
Cantharidin (CTD), the main toxic component of Mylabris, has been extensively used for tumor treatment in recent years. CTD-induced liver toxicity has attracted significant interest in clinic. In this study, biochemical parameters and liver pathological changes were analyzed after CTD was administered to mice by gavage. Subsequently, a lipidomic approach was used to investigate serum lipid metabolism
-
Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-11 Kiarash Ghazvini, Hossein Kamali, Hadi Farsiani, Masoud Yousefi, Masoud Keikha
The Gram-negative bacterium Helicobacter pylori, H. pylori, is associated with significant digestive disorders. However, the effectiveness of bacterial eradication is declining due to drug resistance. A potent anti-H. pylori activity is shown by the natural antimicrobial peptide pexiganan. The current study aimed to evaluate the effectiveness of pexiganan and its lipid-liquid crystals (LLCs) in inducing
-
Enoxaparin for VTE thromboprophylaxis during inpatient rehabilitation care: assessment of the standard fixed dosing regimen BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-10 Amir Haim, Orli Avnery, Deborah Rubin-Asher, Hagay Amir, Kaifa Hashem, Harel Ben Zvi, Motti Ratmansky
We aimed to examine the efficiency of fixed daily dose enoxaparin (40 mg) thromboprophylaxis strategy for patients undergoing inpatient rehabilitation. This was an observational, prospective, cohort study that included 63 hospitalized patients undergoing rehabilitative treatment following sub-acute ischemic stroke (SAIS) or spinal cord injury (SCI), with an indication for thromboprophylaxis. Anti-Xa
-
Fenofibrate alleviates NAFLD by enhancing the PPARα/PGC-1α signaling pathway coupling mitochondrial function BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-03 Xuemei Wang, Jieying Wang, Cao Ying, Yuan Xing, Xuan Su, Ke Men
To comprehend the influences of fenofibrate on hepatic lipid accumulation and mitochondrial function-related signaling pathways in mice with non-alcoholic fatty liver disease (NAFLD) secondary to high-fat diets together with free fatty acids-influenced HepG2 cells model. A random allocation of male 6-week C57BL/6J mice into three groups was done, including controls, model (14 weeks of a high-fat diet)
-
Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-02 Pengfei Li, Ping Du, Jun Peng, Zhixia Zhao, Huiling Li, Weiyue Yu, Shumin Wang, Lihong Liu
Definity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as perflutren, microspheres, which is initially designed to enhance echocardiographic ultrasound images. With no pharmacologic action, Definity can increase the backscatter of ultrasound resulting enhanced ultrasound signals. The objective of this study was to determine the pharmacokinetics
-
Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-02 Jennifer L. Fisher, Amanda D. Clark, Emma F. Jones, Brittany N. Lasseigne
Previous pharmacovigilance studies and a retroactive review of cancer clinical trial studies identified that women were more likely to experience drug adverse events (i.e., any unintended effects of medication), and men were more likely to experience adverse events that resulted in hospitalization or death. These sex-biased adverse events (SBAEs) are due to many factors not entirely understood, including
-
Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-02 Guangwei Jia, Congcong Ren, Hongyan Wang, Caixia Fan
This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to predict changes in the pharmacokinetics (PK) and pharmacodynamics (PD, PDE4 inhibition) of roflumilast (ROF) and ROF N-oxide when co-administered with eight CYP3A4/1A2 perpetrators. The population PBPK model of ROF and ROF N-oxide has been successfully developed and validated based on the four clinical PK studies and
-
Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-02 Yu-Jie Liang, Ding-Xin Long, Shanshan Wang, Hui-Ping Wang, Yi-Jun Wu
Multiple pesticides are often used in combination for plant protection and public health. Therefore, it is important to analyze the physiological changes induced by multiple pesticides exposure. The objective of this study was to investigate the combined toxicity of the widely-used organophosphorus and pyrethroid pesticides diazinon, dimethoate, and cypermethrin. Male Wistar rats were administrated
-
Prevalence and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city, southwestern Uganda BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-02 Allan Phillip Lule, Ogwal Basil Delic, Keneth Katunguka, Francis Muwonge, Tadele Mekuriya Yadesa
Drug-drug interactions (DDIs) influence the effectiveness of medication and thus determine the treatment outcomes of diseases managed with pharmacotherapy. This study aimed to determine the prevalence, severity, and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city. DDIs were identified and classified basing on risk and severity
-
Genetic prediction of antihyperglycemic drug targets and risk of epilepsy: a mendelian randomisation study BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2024-01-02 Kaiping Zhou, Huan Yang, Zhihao Xie, Weiping Wang, Zhenzhen Qu
A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unclear whether antihyperglycemic drugs have a causal role in epilepsy in humans. To investigate this potential causal relationship, a Mendelian randomisation study was conducted using International
-
Amlodipine alleviates renal ischemia/reperfusion injury in rats through Nrf2/Sestrin2/PGC-1α/TFAM Pathway BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-21 Hadi Shirzad, Seyed Amin Mousavinezhad, Mohammad Panji, Moin Ala
Previously, observational studies showed that amlodipine can mitigate calcineurin inhibitor- and contrast-induced acute kidney injury (AKI). Herein, we aimed to measure the effect of amlodipine on renal ischemia/reperfusion (I/R) injury and find the underlying mechanisms. Bilateral renal I/R was induced by clamping the hilum of both kidneys for 30 min. The first dose of amlodipine 10 mg/kg was gavaged
-
In diabetic male Wistar rats, quercetin-conjugated superparamagnetic iron oxide nanoparticles have an effect on the SIRT1/p66Shc-mediated pathway related to cognitive impairment BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-21 Mahnaz Karami Chamgordani, Akram Bardestani, Shiva Ebrahimpour, Abolghasem Esmaeili
Quercetin (QC) possesses a variety of health-promoting effects in pure and in conjugation with nanoparticles. Since the mRNA-SIRT1/p66Shc pathway and microRNAs (miRNAs) are implicated in the oxidative process, we aimed to compare the effects of QC and QC-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) on this pathway. Through the use of the chemical coprecipitation technique (CPT)
-
Addition of progesterone to feminizing gender-affirming hormone therapy in transgender individuals for breast development: a randomized controlled trial BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-20 Benthe A.M. Dijkman, Danithsia Helder, Lidewij S. Boogers, Noor C. Gieles, Jason O. van Heesewijk, Sjoerd te Slaa, Niels P.T.J. Liberton, Chantal M. Wiepjes, Christel J.M. de Blok, Martin den Heijer, Koen M.A. Dreijerink
Feminizing gender-affirming hormone therapy (GAHT) for transgender individuals traditionally includes estradiol and androgen deprivation. Research has demonstrated that breast size as a result of GAHT in transgender women is often limited. Therefore, transgender women often choose to undergo breast augmentation surgery. Progesterone is important for breast development in cisgender women during puberty
-
Effectiveness and safety of different doses of febuxostat compared with allopurinol in the treatment of hyperuricemia: a meta-analysis of randomized controlled trials BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-14 Hong Xie, Nan Hu, Ting Pan, Jun-Cai Wu, Miao Yu, Deng-Chao Wang
The prevalence of hyperuricemia has increased steadily with the continuous improvement of living standards. Some studies have reported the clinical effectiveness and safety of different doses of febuxostat in comparison with allopurinol in hyperuricemia treatment, but the sample sizes of the studies have been small, and the results have been inconsistent. We designed this meta-analysis to evaluate
-
Host microbiome associated low intestinal acetate correlates with progressive NLRP3-dependent hepatic-immunotoxicity in early life microcystin-LR exposure BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-13 Madhura More, Somdatta Chatterjee, Punnag Saha, Dipro Bose, Ayushi Trivedi, Subhajit Roy, Saurabh Chatterjee
Microcystins (MCs), potent hepatotoxins pose a significant health risk to humans, particularly children, who are more vulnerable due to higher water intake and increased exposure during recreational activities. Here, we investigated the role of host microbiome-linked acetate in modulating inflammation caused by early-life exposure to the cyanotoxin Microcystin-LR (MC-LR) in a juvenile mice model. Our
-
Long-term survival in venous thromboembolic disease: rivaroxaban vs. warfarin – propensity score matching study BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-13 Estefan Ramos-Isaza, Eduardo Tuta-Quintero, Alirio Bastidas-Goyes, Diana Diaz-Quijano, Carolina Aponte-Murcia, Julian Espitia-Angel, Daniel Pinto-Beltran, Johan Rincón-Hernández, Juan Sánchez-Cuellar, Jesus Pérez-Bueno, Luis F. Giraldo-Cadavid
Venous thromboembolic disease (VTE) is characterized by obstruction of venous blood flow by a thrombus. Survival data, frequency of disease recurrence, and bleeding rate in patients on anticoagulant therapy with warfarin compared to rivaroxaban in the Latin American population are limited in VTE. A retrospective cohort study with propensity score matching analysis was conducted in patients with pulmonary
-
Levocetrizine attenuates cyclophosphamide-induced lung injury through inhibition of TNF-α, IL-1β, TGF-β and MMP-9 BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-11 Dalia H. El-Kashef, Mona Abdel Rahim
Cyclophosphamide (CP) is an antineoplastic drug commonly used worldwide. Despite its spread, it causes fatal organ toxicity. Lung toxicity is a serious side effect of CP. Actually, in the past three years the world has been facing an un-predicted crisis following COVID-19 pandemic and the associated high-mortality rates attributed to respiratory distress. Accordingly; this study aimed to probe the
-
Comparison of the efficacy of anti-diabetic medications as add-on to metformin in type 2 diabetes mellitus from a real-world database BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-09 Ryosuke Ono, Chika Ogami, Chihiro Hasegawa, Hideto To, Yoshiaki Matsumoto, Yasuhiro Tsuji
Metformin is recommended as a first-line drug in the guidelines of the treatment for type 2 diabetes mellitus. However, high-quality evidence from clinical trials directly comparing the degree of hypoglycemic effect of combination therapy of metformin and a hypoglycemic agent with a different mechanism of action with that of monotherapy of a hypoglycemic drug is lacking. We aimed to examine whether
-
Dolutegravir-induced growth and lifespan effects in Caenorhabditis elegans BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-07 Shin-Huei Kuo, Wen-Li Hsu, Ching-Ying Wu, Yu-Chang Lai, Tun-Chieh Chen
Integrase strand transfer inhibitor (INSTIs)-based combination antiretroviral treatment in people living with HIV (PLWH) has been reportedly correlated with several adverse effects, such as weight gain, fetal defects or psychiatric disorders. To comprehensively understand the adverse effect of INSTIs, our study utilized Caenorhabditis Elegans (C. elegans) as a model to investigate how dolutegravir
-
Antibiotics and antibiotic-associated diarrhea: a real-world disproportionality study of the FDA adverse event reporting system from 2004 to 2022 BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-04 Haining Huang, Lanfang Li, Mingli Wu, Zhen Liu, Yanyan Zhao, Jing Peng, Xiaolei Ren, Shuai Chen
Our study aimed to assess the risk signals of antibiotic-associated diarrhea (AAD) caused by various antibiotics using real-world data and provide references for safe clinical applications. We analyzed data extracted from the FDA Adverse Event Reporting System (FAERS) database, covering the period from the first quarter of 2004 to the third quarter of 2022. We computed the reporting odds ratio (ROR)
-
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-02 Sijie Yu, Yuhan Zhang, Chongkai Shen, Fei Shao
The main purpose was to evaluate the efficacy and tolerability of different medications used to treat bulimia nervosa (BN). Randomized controlled trials (RCTs) were identified from published sources through searches in PubMed, Cochrane Library, Web of Science, and Embase from inception to November 2022. Primary outcomes were changes in the frequency of binge eating episodes and vomiting episodes from
-
Efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a meta-analysis BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-01 Wen Chen, Yubingxue Liu, Luchun Li, Xianghua Zeng
To evaluate the efficacy and safety of thrombopoietin receptor agonists (TPO-RAs) in solid tumors with chemotherapy-induced thrombocytopenia (CIT). We conducted a comprehensive search of PubMed, FMRS, Cochrane Library, Web of Science, EMBASE, and ClinicalTrials.gov for randomized controlled trials (RCTs) reporting the efficacy and safety of TPO-RAs in solid tumors with CIT. The search was limited to
-
Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-12-01 Soon Woo Hong, Kyung Hwa Chang, Chang Jae Woo, Ho Chul Kim, Bong Seop Kwak, Bong Joo Park, Ki Chang Nam
Nebulizers are commonly used to treat respiratory diseases, which are a major cause of morbidity and mortality. While inhalation therapy with antibodies has been evaluated in preclinical studies and clinical trials for respiratory diseases, it has not yet been approved for treatment. Moreover, there is limited information regarding the delivery efficiency of therapeutic antibodies via nebulizer. In
-
In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus™ software BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-28 Lu Wang, Jinliang Chen, Wenjun Chen, Zourong Ruan, Honggang Lou, Dandan Yang, Bo Jiang
The prediction of intestinal absorption of various drugs based on computer simulations has been a reality. However, in vivo pharmacokinetic simulations and virtual bioequivalence evaluation based on GastroPlus™ have not been found. This study aimed to simulate plasma concentrations with different dissolution profiles and run population simulations to evaluate the bioequivalence of test and reference
-
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-27 Amina Sardar, Mehwish David, Sarwat Jahan, Tayyaba Afsar, Aneela Ahmad, Asad Ullah, Ali Almajwal, Huma Shafique, Suhail Razak
Imidacloprid is a neonicotinoid insecticide belonging to the chloronicotinyl nitroguanidine chemical family. Toxicity of IMD for mammals in scientific studies has shown high mutagenic, immunotoxic, teratogenic and neurotoxic effects. The present study was designed to assess the toxic effects of imidacloprid (IMD) on the testicular and epididymis tissues as well as testosterone levels of neonatal male
-
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-25 Temitope Akinwumi Ajani, Kenechukwu Obikeze, Zandisiwe E. Magwebu, Samuel Egieyeh, Chesa G. Chauke
Atherosclerosis is a form of cardiovascular disease that affects the endothelium of the blood vessel. Series of events are involved in the pathophysiology of this disease which includes the breaking down of the connective tissue elastin and collagen responsible for the tensile strength of the arterial wall by proteolytic enzyme. One of these enzymes called Cathepsin S (CatS) is upregulated in the progression
-
Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-23 Bin Ling, Yun Zhu, Zelin Yan, Hao Chen, Hua Xu, Qi Wang, Wanyou Yu, Wei Wang
The study was designed to investigate effects of single intravenous injection of esketamine on the incidence of postpartum depression (PPD) after labor analgesia and explore the potential mechanisms. A total of 120 women who underwent labor analgesia by epidural analgesia pump were enrolled and divided into two groups randomly. Esketamine at a dose of 0.2 mg/kg was intravenously injected after fetal
-
The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-22 Mohsen Yousefi, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Samira Rastgoo, Reza Bagher, Alireza Khadem, Farideh Shiraseb, Omid Asbaghi
Dyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced levels of high-density lipoprotein (HDL), is a major risk factor for cardiovascular diseases (CVD). Several studies have shown the potential of acarbose in improving serum lipid markers. However, there have been conflicting results on the topic in adults. Therefore
-
Study on the association between adverse drug reactions to opioids and gene polymorphisms: a case-case–control study BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-21 Jing Yang, Ying-zi Sun, Qun-fang Li, Zheng Fu, Yu-yao Guan, Chao Song, Lei Zheng
Adverse drug reactions (ADRs) caused by opioid drugs show individual differences. Our objective was to explore the association between gene polymorphism and ADRs induced by opioid drugs. Evidence-based medical data analysis was conducted for genes related to ADRs induced by opioid drugs to select target genes. Sixty patients with cancer pain who had ADRs after taking opioid drugs (morphine, codeine
-
Bisdemethoxycurcumin alleviates LPS-induced acute lung injury via activating AMPKα pathway BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-20 Huifang Li, Qi Zou, Xueming Wang
Inflammation and oxidative stress contribute to the pathogenesis of acute lung injury (ALI), and subsequently result in rapid deterioration in health. Considering the indispensable role of bisdemethoxycurcumin (BDMC) in inflammation and oxidative stress, the present study aims to examine the effect of BDMC on sepsis-related ALI. C57BL/6 mice were administered with BDMC (100 mg/kg) or an equal volume
-
A disproportionality analysis of adverse events associated to pertuzumab in the FDA Adverse Event Reporting System (FAERS) BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-13 Shu-peng Zou, Hai-yun Yang, Meng-ling Ouyang, Qian Cheng, Xuan Shi, Ming-hui Sun
Pertuzumab is widely used for the treatment of HER2 + breast cancer. But its safety in the real world should be continuously monitored. So, we evaluated the safety of pertuzumab by pharmacovigilance analyze based on related adverse events (AEs) from the FDA Adverse Event Reporting System (FAERS) and find whether potential or uncertain adverse events were present. In disproportionality analysis, four
-
In vitro evaluation of cell viability and expression profile of growth factors in mouse Sertoli cells exposed to Delta-9-tetrahydrocannabinol: a mechanistic insight into the cannabinoid-induced testicular toxicity BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-09 Shadi Mohammadpour-Asl, Shiva Roshan-Milani, Amin Abdollahzade Fard, Ali Golchin
The potentially adverse effects of cannabis (marijuana), a common leisure compound, on male reproductive performance are a reason for concern. δ-9-tetrahydrocannabinol (THC), the primary active component of marijuana alters testicular cells’ proliferation and function which affects male fertility and causes testicular cells dysfunction and apoptosis. The main objective of this study was to investigate
-
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson’s disease model BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-07 Zahra Salari, Ghorbangol Ashabi, Ali Fartoosi, Ahmad Fartoosi, Marjan Shariatpanahi, Mehdi Aghsami, Hamed Montazeri, Afshin Kheradmand
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of nigrostriatal dopaminergic neurons and movement impairment. Based on theories, neuroinflammatory processes may be vital in the etiology of PD and other neurodegenerative diseases. Reports show that rotenone has neurotoxic, inflammatory, and motor impairment effects in PD. Sericin is a natural polymer
-
Efficacy of intravenous N acetylcysteine as an adjuvant therapy in the treatment of acute aluminum phosphide Poisoning: a systematic review and meta-analysis BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-03 Heba Othman Shaker, Omar El Sayed Rageh, Maged Alnajar, Nesreen Fares Alshamaly, Walaa Abdelfattah Abdelmaged, Mohamed Abd-ElGawad
Aluminum phosphide toxicity is a serious problem in many countries. Unfortunately, there is no specific antidote. N-acetylcysteine has been used in some studies as adjuvant therapy depending on to its antioxidant properties. We hypothesized that IV N-acetylcysteine is effective in reducing mortality rate compared to supportive treatment alone. We searched in PubMed, Scopus, Web of Science, and Cochrane
-
GHB toxicokinetics and renal monocarboxylate transporter expression are influenced by the estrus cycle in rats BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-11-02 Hao Wei, Jieyun Cao, Tyler Fallert, Su Yeo, Melanie A. Felmlee
The illicit use and abuse of gamma-hydroxybutyric acid (GHB) occurs due to its sedative/hypnotic and euphoric effects. Currently, there are no clinically available therapies to treat GHB overdose, and care focuses on symptom treatment until the drug is eliminated from the body. Proton- and sodium-dependent monocarboxylate transporters (MCTs (SLC16A) and SMCTs (SLC5A)) transport and mediate the renal
-
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-27 Jui-Ting Chang, Yao-Jen Liang, Chia-Yu Hsu, Chao-Yi Chen, Po-Jung Chen, Yi-Feng Yang, Yen-Lin Chen, Dee Pei, Jin-Biou Chang, Jyh-Gang Leu
Correction to: BMC Pharmacol Toxicol 18, 67 (2017). https://doi.org/10.1186/s40360-017-0172-3 In the original publication of this article the following affiliation was missing for Jui-Ting Chang: - Department & Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan The article has been updated to add the missing affiliation. Authors and Affiliations Division of Nephrology, Department
-
Oxidative stress induction by narasin augments doxorubicin’s efficacy in osteosarcoma BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-20 Zhaoming Han, Juguang Yang, Ping Wang, Feng Bian, Jiguang Jia
Complications and fata toxicity induced by chemotherapy are the main challenge for clinical management of osteosarcoma. The identification of agents that can augment the efficacy of chemotherapy at lower doses may represent an alternative therapeutic strategy. Narasin is a polyether antibiotic widely used in veterinary medicine. In this study, we show that narasin is active against osteosarcoma cells
-
Correction: Core decompression combined with local DFO administration loaded on polylactic glycolic acid scaffolds for the treatment of osteonecrosis of the femoral head: a pilot study BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-17 Kaveh Gharanizadeh, Ali Mohammad Sharifi, Hamed Tayyebi, Razieh Heidari, Shayan Amiri, Sajad Noorigaravand
Correction: BMC Pharmacology and Toxicology (2023) 24:44 https://doi.org/10.1186/s40360-023-00682-x Following publication of the original article [1], the authors identified an error in the author details. The correct author details are given below. The author details currently read: 1 Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical
-
Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-13 Lishan Zhong, Yanting Wu, Chen Huang, Kaisheng Liu, Cui-fang Ye, Zhe Ren, Yifei Wang
AT-533 is a novel heat shock protein 90 inhibitor that exerting anti-inflammatory, antiviral, and antitumor efficacy. Furthermore, the gel made of AT-533 as raw material named AT-533 gel has the function of repairing keratitis and dermatitis caused by herpes virus infection. However, the acute safety evaluation of AT-533 and AT-533 gel has not been conducted. Herein, we performed acute toxicological
-
Retraction Note: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-13 Omnia I. Ismail, Eman S. Shaltout, Nora Z. Abdellah, Diab F. Hetta, Wael M. A. Abd El-Ghani, Lobna A. Abdelzaher, Ahmed Mohamed Mohamed Mahmoud, Asmaa M. Hasan, Noha A. Rashed, Noha Esmael Ebrahem
Retraction Note: BMC Pharmacology and Toxicology (2022) 23:4 https://doi.org/10.1186/s40360-021-00546-2 The Editor has retracted this article. After publication, concerns were raised regarding image similarities and irregular features in the presented figures. Specifically: Fig. 2d appears to contain highly similar areas, and an unusual diagonal artifact that appears to duplicate nearby features of
-
The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a systematic review and meta-analysis BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-12 Chun-Lan Yang, Jia-Peng Huang, Ying-chao Tan, Ting-ting Wang, Han Zhang, Yun Qu
Botulinum toxin (BoNT) injection is an important adjunctive method to treat sialorrhea. The purpose of this systematic review was to analyze the effect and safety of BoNT injections in the intervention of sialorrhea with Parkinson’s disease (PD). We searched PubMed, Web Of Science (WOS), Scopus, Cochrane CENTRAL, and Embase from inception until April 2022. Randomized controlled trials or randomized
-
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-12 Lingjun Li, Baole Cai, Hongyang Li, Jun Wei, Lei Tao, Pengcheng Ma
EMLA cream is a local anesthetic. The pharmacokinetics and dermal effects of a topical anesthetic formulation has not been evaluated in healthy Chinese volunteers. The Pharmacokinetics of the lidocaine/prilocaine test (T) or reference (R, EMLA) cream were evaluated in a fasting, single-dose, two-period crossover bioequivalent study conducted in 40 healthy Chinese volunteers. Meanwhile, the dermal effects
-
Metformin alleviates adriamycin resistance of osteosarcoma by declining YY1 to inhibit MDR1 transcriptional activity BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-12 Bowen Wu, Peng Li, Eryue Qiu, Jian Chen
Chemotherapy resistance hinders the successful treatment of osteosarcoma (OS) to some extent. Previous studies have confirmed that metformin (Met) enhances apoptosis induced by chemotherapeutic drugs, but the underlying mechanism remains unclear. To establish adriamycin (ADM)-resistant MG-63 (MG-63/ADM) cells, the dosage of ADM was progressively increased. The results of qRT-PCR and Western blotting
-
Correction to: efficacy and safety of the switch of Triumeq® to generic (abacavir + lamivudine) + Tivicay®: data at 24 weeks BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-06 Julián Olalla, Javier Pérez-Stachowski, Begoña Tortajada, Alfonso Del Arco, Efrén Márquez, Javier De la Torre, Miriam Nieto, José María García de Lomas, José Luis Prada, Javier García-Alegría
Correction to: BMC Pharmacol Toxicol 19, 63 (2018). https://doi.org/10.1186/s40360-018-0252-z The original publication of this article did not provide clear clarification that the switch from brand to a generic drug was not done by the authors for the intention of the study. Patients were informed of the options and on switching to generic drugs the patients were able to expressed their agreements
-
Butyrate alleviates renal inflammation and fibrosis in a rat model of polycystic ovarian syndrome by suppression of SDF-1 BMC Pharmacol. Toxicol. (IF 2.605) Pub Date : 2023-10-03 Al-Amin M. Bashir, Kehinde S. Olaniyi
Polycystic ovarian syndrome (PCOS) is a multifactorial condition with metabolic-related complications, such as diabetic nephropathy and chronic renal disorder, which are the leading cause of renal transplant globally. Protective effects of histone deacetylase (HDAC) inhibitors (HDACi) have been documented in metabolic-linked pathologies. Nonetheless, the current study investigated the restorative role