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FTO in Lung Cancer: Its Progression and Therapeutic Potential Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-15 Xue-Fen Chen, Chen Gong
: One of the most fatal and frequent malignancies on the planet is lung cancer. Its occurrence and development are the results of multifactorial and multigenic interactions. In recent years, RNA N6-methyladenosine transferase (FTO) has gained significant attention in the field of oncology. FTO is the first RNA demethylase to be found to control target mRNA demethylation. The growth, proliferation,
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Daptomycin Inhibits Multiple Myeloma Progression through Downregulating the Expression of RPS19 Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-08 Yijun Zhuang, Yin Zhang, Caiyun Chen, Jincheng Chen, Qiuxia Xu, Peihong Wang
Objectives:: This study aimed to explore new therapeutic drugs for multiple myeloma (MM). MM is a common plasma cell malignant proliferative disease, accounting for 15% of hematological malignancies. The role of daptomycin (DAP), a potential anti-tumor drug, remains unclear in MM. In the present research, we investigated the anticancer effect of DAP in MM cell line RPMI 8226. Methods:: RPMI 8226 cells
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DPP2/7 is a Potential Predictor of Prognosis and Target in Immunotherapy in Colorectal Cancer: An Integrative Multi-omics Analysis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-08 Zhihao Shang, Yueyang Lai, Haibo Cheng
Background:: Colorectal cancer (CRC) ranks among the leading causes of cancerrelated deaths. Objective:: This study aimed to illuminate the relationship between DPP7 (also known as DPP2) and CRC through a combination of bioinformatics and experimental methodologies. Methods:: A multi-dimensional bioinformatic analysis on DPP7 was executed, covering its expression, survival implications, clinical associations
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Identification of PLAC8 as a Potential Biomarker for the Diagnosis of Interstitial Cystitis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-05 Zhilei Zhang, Mingwei Xu, Xiangyan Zhang, Fei Xie, Xiaofei Zhang, Peng Li
Background:: Interstitial cystitis is a diagnosis of exclusion due to the complexity of its etiology and pathology, which is a chronic disease with an unknown etiology. To our knowledge, few studies were performed to identify predictive biomarkers for interstitial cystitis. Objective:: This study aimed to identify and validate potential biomarkers for interstitial cystitis (IC). Methods:: The interstitial
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Plant Adaptation and Tolerance to Heat Stress: Advance Approaches and Future Aspects Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-05 Vineeta Pandey, Sonia Singh
: Heat stress impacts plant growth at all phases of development, although the particular threshold for heat tolerance varies significantly across different developmental stages. During seed germination, elevated temperatures can either impede or completely halt the process, contingent upon the plant type and the severity of the stress. During advanced stages, high temperatures can have a negative impact
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Integrated Serum Pharmacochemistry and Network Pharmacological Analysis Used To Explore Possible Anti-Aging Mechanisms of the Ginsenosides Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-05 Jing Li, Ruigang Li, Qing Yang, Xiaoran Liu, Xiaobo Qu, Na Li
Background:: Although constitutive ginsenosides are credited with ginseng's remarkable anti-aging efficacy, the mechanism of action and bioactive components of ginsenosides are unclear. Objective:: The goal of the study was to examine the effect of ginsenosides on D-galactose (Dgal)- induced aging in rats and to figure out the underlying molecular mechanism using serum pharmacochemistry and network
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Unraveling Amentoflavone's Therapeutic Potential in Alzheimer's Disease: A Preclinical Assessment Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-05 Sushma Singh, Neetu Agrawal, Ahsas Goyal
: Alzheimer’s disease is one of the neurodegenerative diseases which causes cognition deficit. There are currently few medications available to treat Alzheimer's disease, even though researchers have devoted a great deal of time studying the condition and offering many benefits. Thus, only a few drugs are available for the treatment of Alzheimer’s disease. Amentoflavone is a dietary component found
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Pharmacological Mechanisms of Kirenol against Ovarian Carcinoma: A Network Pharmacology and Experimental Validation Study In Vitro Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-03-01 Xiaoling Mao, Hong Zhu, Jun Gao, Shixin Lin, Yin Bao, Mingyue Zhang, Huan Yang
Background: Ovarian carcinoma is an aggressive gynecological malignancy. Kirenol, a diterpene compound, has recently gained attention for its potential anticancer properties. However, its exact anti-tumor mechanism remains largely unexplored. Objective: In this study, we explored the inhibitory effects of Kirenol on ovarian cancer using network pharmacology and in vitro experiments and elucidated its
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Is Ancient Medical Treatment an Option for Curating Osteosarcoma Combined with Chemotherapy? A Basic Analysis of Clinic Pharmacy Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-27 Jian-yu Hu, Ya-ru Gao, Yu-qi Bao, Jing Zhao, Bo Liu, Chang-wei Zhao, Zheng-yao Zhang
Background:: As a malignant tumor, osteosarcoma (OS) ranks first place among adolescent cancers and is susceptible to developing resistance to chemotherapeutic agents. Differently, traditional Chinese medicine (TCM) has multiple pharmacodynamic targets and complex biological components, which can inhibit tumor survival and drug resistance and gradually play an important role in the treatment of sarcoma
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Quercetin Prevents HSpertension in Dahl Salt-sensitive Rats Fed a High-salt Diet Through Balancing Endothelial Nitric Oxide Synthase and Sirtuin 1 Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-22 Guanji Wu, Fuqiang Liu, Qing Cui, Tao Zhang, Junjun Hao, Jianjun Bao
Background: A high-salt diet is a leading dietary risk factor for elevated blood pressure and cardiovascular disease. Quercetin reportedly exhibits cardioprotective and antihypertensive therapeutic effects. background: A high-salt diet is a leading dietary risk factor for elevated blood pressure and cardiovascular disease. Quercetin reportedly exhibits cardioprotective and antihypertensive therapeutic
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Zuogui Pill Promotes Neurite Outgrowth by Regulating OPN/ IGF-1R/PTEN and Downstream mTOR Signaling Pathway Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-16 Yan Liu, Dan Wu, Xiaohui Yan, Xinyu Xu, Jian Zhu, Changyin Li, Qinghua Feng, Li Li, Minghua Wu, Wenlei Li
Aim and Objective: Zuogui pill (ZGP) is the traditional Chinese medicine for tonifying kidney yin. Clinical and animal studies have shown that ZGP effectively enhances neurologic impairment after ischemic stroke, which may be related to promoting neurite outgrowth. This investigation aimed to prove the pro-neurite outgrowth impact of ZGP and define the underlying molecular pathway in vitro. Materials
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A Six-gene Prognostic Model Based on Neutrophil Extracellular Traps (NETs)-related Gene Signature for Lung Adenocarcinoma Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-15 Guiyan Mo, Xuan Long, Limin Cao, Yuling Tang, Yusheng Yan, Ting Guo
Background: Lung adenocarcinoma (LUAD) is one of the most common malignant cancers. Neutrophil extracellular traps (NETs) have been discovered to play a crucial role in the pathogenesis of LUAD. We aimed to establish an innovative prognostic model for LUAD based on the distinct expression patterns of NETs-related genes. background: Neutrophil extracellular traps (NETs) plays dual roles in lung adenocarcinoma
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A Novel KIF4A-Related Model for Predicting Immunotherapy Response and Prognosis in Kidney Renal Clear Cell Carcinoma Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-15 Guang Hua Yang, Xu Dong Ma, Xi Feng Wei, Ran Lu Liu, Chao Wang
Background:: The efficacy of chemotherapy in treating Kidney Renal Clear Cell Carcinoma (KIRC) is limited, whereas immunotherapy has shown some promising clinical outcomes. In this context, KIF4A is considered a potential therapeutic target for various cancers. Therefore, identifying the mechanism of KIF4A that can predict the prognosis and immunotherapy response of KIRC would be of significant importance
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Exploring the Potential Mechanisms of Action of Gentiana Veitchiorum Hemsl. Extract in the Treatment of Cholestasis using UPLC-MS/MS, Systematic Network Pharmacology, and Molecular Docking Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-15 Yue Wang, Nixia Tan, Rong Su, Zhenhua Liu, Qi Dong, Na Hu
Introduction: Gentiana veitchiorum Hemsl. (GV) has a long history in Tibetan medicine for treating hepatobiliary disease cholestasis. However, the mechanisms mediating its efficacy in treating cholestasis have yet to be determined. background: Gentiana veitchiorum Hemsl. (GV) has a long history in Tibetan medicine to treat cholestasis. However, the mechanisms mediating its efficacy in the treatment
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Phage Therapy in Bacterial Pneumonia Models: A Systematic Review and Meta-Analysis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-15 Mohammad Akhlaquer Rahman, Kapil Kumar Verma, Mahesh Kumar Posa
Background:: Phage therapy could play an important role in the bacterial pneumonia. However, the exact role of phage therapy in bacterial pneumonia is unclear to date. Aim:: The current study aims to find out the role of phage therapy in preclinical models of bacterial pneumonia. Methods:: The studies were searched in databases with proper MeSH terms along with Boolean operators and selected based
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Observation of the Short-term Efficacy of Technetium-99 Conjugated with Methylene Diphosphonate Combined Therapy in the Treatment of Postmenopausal Osteoporosis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-15 Wen Sun, Quan Xie, Juan-Juan Yan, Ying Huang, Ying Zhou, Chao-Qun Wang, Huan Xiao
Objective: To investigate the short-term efficacy and safety of Yunke (technetium-99 conjugated methylene diphosphonate) combined with pulsed electromagnetic field (PEMF) and Gukang capsule in the treatment of postmenopausal osteoporosis (PMOP). Methods: A total of 112 patients with PMOP who received treatment in the Department of Nuclear Medicine of the hospital from January 2019 to June 2020 were
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Construction and Application of a Traditional Chinese Medicine Syndrome Differentiation Model for Dysmenorrhea Based on Machine Learning Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-14 Limin Zhang, Jianing You, Yiqing Huang, Ruiqi Jing, Yifei He, Yujie Wen, Lulu Zheng, Yong Zhao
Background: Dysmenorrhea is one of the most common ailments affecting young and middle-aged women, significantly impacting their quality of life. Traditional Chinese Medicine (TCM) offers unique advantages in treating dysmenorrhea. However, an accurate diagnosis is essential to ensure correct treatment. This research integrates the age-old wisdom of TCM with modern Machine Learning (ML) techniques
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Prognosis and clinical significance of Piezo2 in tumor: a meta-analysis and database validation Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-13 Tong Liang, Junhong Wang, Chenglou Zhu, Yongli Hu, Zhenhua Gao, Mingxu Da
Objective:: The objective of this study is to assess the correlation between Piezo2 and tumors through a comprehensive meta-analysis and database validation Methods:: Case-control studies investigating the association between Piezo2 and tumors were obtained from various databases, including China National Knowledge Infrastructure (CNKI), SinoMed, Embase, Web of Science, The Cochrane Library, and PubMed
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Matrine: A Promising Treatment for Ulcerative Colitis by Targeting the HMGB1/NLRP3/Caspase-1 Pathway Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-13 Kexin Sun, Weiye Lin, Qianran Hong, Shuangyu Chen, Jiayang Li, Shengliang Qiu
Background:: Previous studies have found that matrine (MAT) effectively treated Ulcerative Colitis (UC). The purpose of this study is to explore its mechanism based on the HMGB1/NLRP3/Caspase-1 signaling pathway. Methods:: MAT was administered intragastrically to DSS-induced UC mice for 14 days. The Disease Activity Index (DAI) and histological staining were measured to detect histopathological changes
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Research Progress of TCM Therapy for Rotator Cuff Injury Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-06 Xianquan Zhang, Guanghui Zhou, Zhuoxu Gu, Minghui Luo, Guihong Liang
: Rotator cuff injury is a common orthopedic disease with high morbidity, which is one of the most important reasons for shoulder pain and limited movement. With the development of more research, the Traditional Chinese Medicine (TCM) therapy for rotator cuff injury is increasingly rich and has achieved a good curative effect. TCM has certain characteristics and advantages, which may become the main
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Potential Antidiabetic Activity of β-sitosterol from Zingiber roseum Rosc. via Modulation of Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-02 Muhammed Amanat, A F M Shahid Ud Daula, Randhir Singh
Aim: To evaluate the antidiabetic potential of β-sitosterol from Zingiber roseum. Background: Diabetes mellitus is a cluster of metabolic disorders, and 90% of diabetic patients are affected with Type II diabetes (DM2). For the treatment of DM2, thiazolidinedione drugs (TZDs) were proposed, but recent studies have shown that TZDs have several detrimental effects, such as weight gain, kidney enlargement
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The Different Therapeutic Effects of Traditional Chinese Medicine Shensong Yangxin Capsule and Salubrinal in High-intensity Exercise-induced Heart Failure in Rats with Acute Myocardial Infarction Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-02 Junli Lu, Yanzhuo Ma, Hongzhi Lv, Congxin Li, Leisheng Ru, Jian Zhao, Dongmei Wang
Background: Currently, endoplasmic reticulum stress is studied utilizing a dephosphorylation inhibitor (Sal). The traditional Chinese patent medicine and simple formulation Shensong Yangxin Capsule is a commonly used medication for the treatment of arrhythmia. However, the efficacy and underlying mechanism of the capsule in treating post-ischemic heart failure in myocardial tissue have not yet been
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Research Progress in Single-herb Chinese Medicine and Compound Medicine for Knee Osteoarthritis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-02 Guanghui Zhou, Xianquan Zhang, Zhuoxu Gu, Jinlong Zhao, Minghui Luo
: Due to an increase in the aging population, osteoarthritis (OA), especially knee osteoarthritis (KOA), has increasingly become one of the diseases affecting the quality of life of the elderly. As the pathogenesis of KOA is still unclear, Western medicine treatment lacks specificity, and surgical treatment is difficult to cover all patients. Therefore, in recent years, traditional Chinese medicine
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Design, Virtual Screening, Molecular Docking, ADME and Cytotoxicity Studies of 1,3,5-Triazine Containing Heterocyclic Scaffolds as Selective BRAF Monomeric, Homo and Heterodimeric Inhibitors Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-02 Ankit Kumar Singh, P. Sreelakshmi, Prateek Pathak, Adarsh Kumar, Harshwardhan Singh, Jagat Pal Yadav, Amita Verma, Maria Grishina, Pradeep Kumar
Background: v-RAF murine sarcoma viral homolog B1 (BRAF) is one of the most frequently mutated kinases in human cancers. BRAF exhibits three classes of mutations: Class I monomeric mutants (BRAFV600), class II BRAF homodimer mutants (non-V600), and class III BRAF heterodimers (non-V600). Method: In this manuscript, the protein-ligand interaction site of all three mutants: BRAF monomer, BRAF homodimer
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Development and Validation of Anoiki-Related Lncrna Signature Prediction Model for KIRC Prognosis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-02 Yao Su, Jin Yang
Background: Various cancer types have been studied and understood using long noncoding RNA (lncRNA). Despite this, only a few studies have examined anoikis-related lncRNAs in kidney renal clear cell carcinoma (KIRC). As a result, this study evaluated a powerful prognostic model for KIRC patients based on anoikis-lncRNAs and identified potential biological targets. Methods: Anoikis-related lncRNAs associated
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Narrative Review of Traditional Chinese Medicine in the Treatment of Postmenopausal Osteoporosis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-02 Li Qi, Wang Wei-guo, Huang Xu-dong, Zhao Xiu-mei, XU Xiao-dong, Zhang Cheng-ming
: An increasing percentage of people in China are suffering from osteoporosis, particularly postmenopausal osteoporosis (PMOP), as the country rapidly evolves into an aging culture. Patients with osteoporosis are inclined to endure fractures, as well as deformities and impairments, which drastically decrease people’s quality of life. The benefits of traditional Chinese medicine (TCM) treatment have
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Cu-Co Bimetallic Catalyst-based Electrochemical Sensing Platform for Determination of Bisoprolol in Clinical Samples Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-02 Mohammad Reza Salemi, Shahla Fathi, Fereshteh Chekin, Banafsheh Norouzi
Background: Bisoprolol (BIS) is a selective beta-blocker. It has been successfully used to treat hypertension and angina pectoris. An overdose of BIS can lead to serious complications. An overdose is a medical emergency that requires immediate medical attention to overcome the adverse effects of the overdose. Hence, sensitive, reliable, and cost-effective methods are required for the determination
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Inhibition of Taurine-upregulated Gene 1 Upregulates MiR-34a-5p to Protect against Myocardial Ischemia/Reperfusion via Autophagy Regulation Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Qunjun Duan, Aiqiang Dong, Haifeng Cheng, Shufen Zhang, Wei Chen, Weijun Yang
Background:: Taurine upregulated gene 1 (TUG1) has been identified on long noncoding RNA (lncRNA); however, its function in myocardial cells following ischemia/ reperfusion (I/R) injury has not been explored. This study aimed to investigate the role of LncTUG1 in I/R injury by focusing on its relationship with autophagy induction by regulating miR-34a-5p expression. Methods:: We established a myocardial
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Identification of Novel Hub Genes Associated with Inflammation and Autophagy in Astragaloside Membranaceus ameliorates Lupus Nephritis by Bioinformatics Analysis and Molecular Dynamics Simulation Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Kaili Kong, Xiaomei Qiao, Ting Liu, Xiaoxia Wang, Rui Li, Jingai Fang, Xiaodong Zhang
Background:: Lupus nephritis is an autoimmune disease, and its pathogenesis involves inflammation and autophagy disorders. Studies have demonstrated that Astragalus membranaceus can effectively suppress the progression of LN, but the underlying therapeutic target is still unclear. Objection:: This study aimed to investigate the therapeutic target whereby AM ameliorates LN Method:: We downloaded AM
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Exploring the Potential Role of Massa Medicata Fermentata in Alcoholic Liver Injury Disease Based on Network Pharmacology and Animal Experiments Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Lu Yang, Yuchen Bao, Qinwen Fu, Yue Fu, Qingqing Tian, Yu Tang, Zihan Xia, Huifang Zhou, Chuyue Wu, Jilin Sun, Qinwan Huang
Background:: ALD is a chronic liver disease caused by chronic excessive alcohol consumption, for which there are no drugs with better efficacy. Ancient literature and modern studies have shown that Massa Medicata Fermentata (MMF) has a hangover effect and ameliorates hepatic inflammation, so we believe that MMF has a potential role in the treatment of alcoholic liver disease. Methods:: UPLC-Q-Orbitrap
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Network Pharmacology and Experimental Validation to Elucidate the Pharmacological Mechanisms of Luteolin Against Chondrocyte Senescence Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Ling Long, Xiaokai Tang, Yi Wang, Jiaxiang Gu, Jiachao Xiong, Hao Luo, Hao Lv, Faxin Zhou, Kai Cao, Sijian Lin
Background:: Luteolin, a flavonoid found in various medicinal plants, has shown promising antioxidant, anti-inflammatory, and anti-aging properties. The cartilaginous endplate (CEP) represents a crucial constituent of the intervertebral disc (IVD), assuming a pivotal responsibility in upholding both the structural and functional stability of the IVD. Objective:: Exploring the precise mechanism underlying
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Understanding the Molecular Mechanisms of H2's Regulatory Effect on miR-29s for Brain Protection during Deep Hypothermic Circulatory Arrest Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Hongmei Li, Li Shen, Junwen Ge, Hongyun Li, Feng Chen, Xiaolong Chen, Haifa Hong
Introduction:: Research regarding post-operative brain protection after deep hypothermic circulatory arrest (DHCA) has gained attracted significant attention. We previously demonstrated that hydrogen can significantly reverse DHCA-induced brain damage. Method:: In the current research, we have established the DHCA model successfully using a modified four-vessel occlusion method and injected miR-29s
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Investigating the Effect of Vitamin a on Orthodontic Tooth Movement: An Experimental Study Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Pengxiang Shi, Jing Zhao, Feng Wang
Background: Vitamin A is essential not only for bone metabolism and development but also for the normal functioning of many physiological processes in the body. Despite vitamin A's important involvement in bone metabolism, its effect on orthodontic tooth movement is not entirely known. background: Vitamin A is essential not only for bone metabolism and development, but also for the normal functioning
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GATA6 Suppresses Lung Adenocarcinoma Progression by Activating CFTR to Modulate Arachidonic Acid Metabolism Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Yong Lin, Yushan Chen, Yi Zhang, Jianming Weng, Rongqiang Shen, Wenshan Zhang, Yulin Lin
Background: CFTR, which belongs to the ATP-binding cassette transporter family and whose members are always involved in cancer progression, is implicated in lung adenocarcinoma (LUAD) progression, but the underlying mechanism remains undefined. Therefore, this study intended to investigate how CFTR works exactly on LUAD progression. background: CFTR, which belongs to the ATP-binding cassette transporter
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Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Cordycepin against Pulmonary Arterial Hypertension in Rats Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Jiangpeng lin, Yuzhuo Zhang, Shuangfeng Lin, Haiming Ding, Weihua Liu
Background:: Pulmonary Arterial Hypertension (PAH) is a fatal disease with high morbidity and mortality. Cordycepin has anti-inflammatory, antioxidant and immune enhancing effects. However, the role of Cordycepin in the treatment of PAH and its mechanism is not clear. Methods:: The Cordycepin structure and PAH-related gene targets were obtained from public databases. The KEGG and GO enrichment analysis
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Prediction of Anti-rheumatoid Arthritis Natural Products of Xanthocerais Lignum Based on LC-MS and Artificial Intelligence Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-02-01 Hao Qian, Zhibing Xiao, Lei Su, Yaqiong Yang, XiangYang Tian, Xiaoqin Wang
Aims: Employing the technique of liquid chromatography-mass spectrometry (LCMS) in conjunction with artificial intelligence (AI) technology to predict and screen for antirheumatoid arthritis (RA) active compounds in Xanthocerais lignum. Background: Natural products have become an important source of new drug discovery. RA is a chronic autoimmune disease characterized by joint inflammation and systemic
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(S)-10-Hydroxycamptothecin Inhibits EMT-evoked Osteosarcoma Cell Growth and Metastasis by Activating the HIPPO Signaling Pathway Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-29 Xiaoping Ma, Junli Chang, Xingyuan Sun, Chujie Zhou, Peng Zhao, Yanping Yang
Background: Osteosarcoma is the most common primary bone cancer in children and adolescents with high metastatic ability. Aim: This study aimed to explore the inhibitory effects of (S)-10-hydroxycamptothecin (HCPT) on osteosarcoma cell growth and metastasis as well as the underlying mechanism. Method: The osteosarcoma cells of 143B and U-2 OS (U-2), treated with HCPT (20, 100, or 300 nM), underwent
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The Role of Zuo Jin Wan in Modulating the Tumor Microenvironment of Colorectal Cancer Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-29 Jiajia Wang, Dongming Hua, Mengyao Li, Ningning Liu, Yingru Zhang, Yiyang Zhao, Shasha Jiang, Xueqing Hu, Yan Wang, Huirong Zhu
Introduction: Traditional Chinese medicine (TCM) can modulate the immune function of tumor patients in various ways. Zuojin Wan (ZJW, a 6:1 ratio of Huanglian and Wuzhuyu) can modulate the microenvironment of ulcerative colitis, but its role in regulating the CRC microenvironment remains unclear. Exploring the role of ZJW in CRC immunomodulation may improve the antitumor effect of existing immunotherapeutic
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Clinical and Animal Studies of Waist and Knee Scraping Therapy for Knee Osteoarthritis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-29 Qianhong Jin, Mingrui Chen, Jing Kong, Dandan Chen, Xuan Wu, Xiaoqing Shi, Lishi Jie, Likai Yu, Sha Li, Zhengxiang Dai
Background: Knee osteoarthritis (KOA) is a degenerative condition with knee pain as the main clinical manifestation. Scraping is one of the commonly used traditional Chinese medicine treatment methods, which activates blood circulation, removes blood stasis, reduces inflammation, and so on. Although scholars have proposed that the synergistic treatment of the waist and knee for KOA is superior to simple
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Guidelines for the Diagnosis and Treatment of Rotator Cuff Tear with Integrated Traditional Chinese and Western Medicine Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-26 Ling-Feng Zeng, Xian-Quan Zhang, Wei-Yi Yang, Jun Liu
Rotator cuff tear is one of the common diseases among middle-aged and elderly people, which has a great impact on patients' physical and mental health and quality of life. The integrative medicine based on traditional Chinese medicine has certain characteristics and advantages in the diagnosis and treatment of Rotator cuff tear. Chinese medicine, which mainly focus on plant-based natural products,
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Fructus mori: An Updated Review on Botany, Phytonutrient, Detection, Bioactivity, Quality Marker, and Application Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-26 Ling-Na Li
Background: Fructus mori (mulberry) is not only a delicious fruit with rich phytonutrients and health functions but also a medicinal plant with many clinical therapeutic values for tonifying kidneys and consolidating essence, making hair black and eyes bright. Methods: The related references about F. mori in this review from 1996 to 2022 had been collected from both online and offline databases, including
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Application of Carbon-based Nano Adsorbents in the Extraction of Amphetamines from Urine Samples Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-26 Arezou Taghvimi, Siavoush Dastmalchi, Samin Hamidi, Sevinc Kurbanoglu, Anis Khoshkbar Sadigh, Yousef Javadzadeh
: Amphetamines, as psychoactive drugs, are extensively abused in society and cause serious mental and physical disorders among young people. Furthermore, the extremely euphoric and excited sense of stimulant consumption leads to dramatic social problems. Determination of various analytes and related metabolites in the complex biological matrices at trace levels has made sample preparation an indispensable
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Magnetic Nanomaterials for Sample Preparation of Disease-related Biomarkers Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-26 Samin Hamidi, Mohammadreza Siahi-Shadbad, Arezou Taghvimi, Sevinc Kurbanoglu
: Measuring clinically relevant biomarkers is critical for disease screening, diagnosis, and therapeutic monitoring. However, analyzing trace biomarkers in complex biological fluids remains challenging. Magnetic solid phase extraction (MSPE) has recently emerged as a promising sample preparation approach due to its simplicity, efficiency, and ability to selectively isolate biomarkers. Databases, including
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Recent Advances in Electrochemical Biosensors Targeting Stress Markers Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-26 Deepti Katiyar, Manish .
Introduction: When the body experiences a change in its internal environment due to factors such as mood (euphoria, stress) and illness, it releases biomarkers in large quantities. These biomarkers are used for detecting a disease at its early stages. This involves the detection of insufficient quantities of biocomponents, which can be done by using nanomaterials, conventional materials, and biotechnology;
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Network Pharmacology Study on the Underlying Mechanism of Danggui–Kushen Herb Pair in Adjuvant Chemotherapeutics against Breast Cancer Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-25 Yijuan Hu, Jiaolong He, Yunling Xu
Background: The Danggui–Kushen herb pair (DKHP) is a classic prescription that has long been used in combination with chemotherapeutic drugs to improve the immune status of patients with breast cancer (BC), however, the active components and the underlying pharmacological mechanisms remain unclear. Therefore, this study aimed to elucidate the possible mechanism of action of DKHP against BC-based comprehensive
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Microfluidics-assisted Tumor Cell Separation Approaches for Clinical Applications: An Overview on Emerging Devices Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-25 Nahid Shanehband, Seyed Morteza Naghib
: Recent advances in science and technology have led to revolutions in many scientific and industrial fields. The term lab on a chip, or in other words, performing a variety of complex analyses in just a short time and a minimal space, is a term that has become very common in recent years, and what used to be a dream has now come to life in practice. In this paper, we tried to investigate a specific
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Association between Postmenopausal Osteoporosis and IL-6、TNF-α: A Systematic Review and A Meta-analysis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-25 Xudong Huang, Baihe Ni, Qi Li, Meichen Liu, Minghua Zhao, Yanqi Zhang, Xiaolin Shi, Weiguo Wang
Background: Postmenopausal osteoporosis (PMOP) greatly increases the risk of bone fracture in postmenopausal women, seriously affects the quality of life of patients, and is an important global public health problem. Persistent chronic systemic inflammation may be involved in the change process of PMOP, and many cytokines, such as TNF-alpha and Interleukin-6, play an important role in the inflammatory
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Association of CirAEs and Efficacy in NSCLC Patients Treated with PD-1/PD-L1: A Meta-analysis of Cohort Studies Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-24 Junru Lu, Jiaming Zhu, Guan Jiang
Purpose: To systematically evaluate the relationship between cutaneous immunerelated adverse events (cirAEs) and the efficacy of PD-1/PD-L1 in the treatment of non-small cell lung cancer (NSCLC) and to provide an evidence-based reference for the clinical application of PD-1/PD-L1 and safety evaluation. Methods: Electronic databases (PubMed, Embase, Medline, Web of Science, and the Cochrane Library)
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Potential Role of Oxidative Stress in the Pathophysiology of Neurodegenerative Disorders Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-21 Sonia Singh, Ashima Ahuja, Shilpi Pathak
: Neurodegeneration causes premature death in the peripheral and central nervous system. Neurodegeneration leads to the accumulation of oxidative stress, inflammatory responses, and the generation of free radicals responsible for nervous disorders like amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders. Therefore, focus must be diverted towards treating
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Network Pharmacology Analysis and In Vitro Validation of the Active Ingredients and Potential Mechanisms of Gynostemma Pentaphyllum Against Esophageal Cancer Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-21 Jianxin Guo, Zhongbing Wu, Xiaoyue Chang, Ming Huang, Yu Wang, Renping Liu, Jing Li
Background: Esophageal cancer (EC) is one of the deadliest malignancies worldwide. Gynostemma pentaphyllum Thunb. Makino (GpM) has been used in traditional Chinese medicine as a treatment for tumors and hyperlipidemia. Nevertheless, the active components and underlying mechanisms of anti-EC effects of GpM remain elusive. Objective: This study aims to determine the major active ingredients of GpM in
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The Role of Innate Immunity in Osteoarthritis and the Connotation of "Immune-joint" Axis: A Narrative Review Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-21 Gaoyan Kuang, Xuyi Tan, Xin Liu, Naping Li, Nanxing Yi, Yilin Mi, Qiyun Shi, Fan Zeng, Xinjun Xie, Min Lu, Xiaotong Xu
: Osteoarthritis (OA) is a degenerative disease that results in constriction of the joint space due to the gradual deterioration of cartilage, alterations in subchondral bone, and synovial membrane. Recently, scientists have found that OA involves lesions in the whole joint, in addition to joint wear and tear and cartilage damage. Osteoarthritis is often accompanied by a subclinical form of synovitis
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Use of Network Pharmacology and Experiment Validation to Uncover the Mechanism of Jianshen Lishui Prescription in the Treatment of Intracerebral Hemorrhage Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-21 Gao Yuguang, Huang Deqing, Zhong Jie, Ma Yujuan, Yang Kan, Liao Yuxiong, Zhu Qiong, Liu Qiqi
Background: As a Chinese medicinal formula, the Jianshen Lishui prescription has been clinically proven to be effective in treating intracerebral hemorrhage (ICH). Yet, the mechanisms involved are unknown. Methods: (1) Network pharmacology analysis: It involved the screening of active components in the Jianshen Lishui prescription, identification of potential targets for these components, and the screening
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Screening for Biomarkers Related to Pigmentation and Formation in Vitiligo Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-17 Ying Shi, Mengyun Su
Background: Vitiligo is an autoimmune skin disorder primarily characterized by the absence of melanocytes, leading to the development of white patches on the patient's skin. Narrowband Ultraviolet B (NB-UVB) therapy is among the most effective approaches for stimulating the reformation of hyperpigmentation. This treatment utilizes a narrow spectrum of NBUVB wavelengths ranging from 311 to 313 nm to
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TOMM40 Correlates with Cholesterol and is Predictive of a Favorable Prognosis in Endometrial Carcinoma Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-17 Yan chen, Yi Luo, Jinling Long, Siyun liu, Linbeini zhao, Baishu chen, Qiuyun mu
Background: A link between cholesterol and endometrial cancer has been established, but current studies have been limited in their findings. We aimed to elucidate the causal relationship between cholesterol and endometrial cancer and to find prognostic genes for endometrial cancer. background: A link between cholesterol and endometrial cancer has been established, but current studies have been limited
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Investigation of the Potential Mechanism of Compound Dragon's Blood Capsule against Myocardial IschemiaBased on Network Pharmacology Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-17 Xin Su, Hongwei Xue, Yang Lou, Xinkai Lv, Xiao Mi, Juan Lu, Xi Chen
Background: Dragon's blood is widely consumed in China, Vietnam and Laos to promote blood circulation. A Compound Dragon's blood capsule (CDC) is a patented medicine composed of dragon’s blood, notoginseng, and borneol. This combination is purported to stabilize coronary heart disease and myocardial ischemia. However, the possible mechanisms and the characterization of its drug targets’ relevance at
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Disulfidptosis-related Protein RPN1 May be a Novel Anti-osteoporosis Target of Kaempferol Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-12 Chengzhen Pan, Chi Zhang, Zonghan Lin, Zhou Liang, Yinhang Cui, Zhihao Shang, Yuanxun Wei, Feng Chen
Background: Osteoporosis (OP) is an age-related skeletal disease. Kaempferol can regulate bone mesenchymal stem cells (BMSCs) osteogenesis to improve OP, but its mechanism related to disulfidptosis, a newly discovered cell death mechanism, remains unclear. Objective: The study aimed to investigate the biological function and immune mechanism of disulfidptosis- related ribophorin I (RPN1) in OP and
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Mechanism of Tonifying Spleen-lung Recipe in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Observational Data Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-12 Hongjin Wu, Shenguang Li, Xiaomei Du, Kaigong Zhu, Jing Li
Background: Chronic bronchitis is a type of common chronic inflammatory respiratory disease, which is mainly characterized by chronic cough and expectoration. Clinical practice and experimental research have shown that the modified tonifying spleen-lung method has significant preventive and therapeutic effects on chronic lung diseases, but the mechanism of TSLR in the treatment of chronic bronchitis
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Network Pharmacology and Experimental Validation Explore the Pharmacological Mechanisms of Herb Pair for Treating Rheumatoid Arthritis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-12 Xi-xi Xu, Hua Shao, Qiao-xue Wang, Zi-yuan Wang
Objective: This study aimed to elucidate the multitarget mechanism of the Mori Ramulus - Taxilli Herba (MT) herb pair in treating rheumatoid arthritis (RA). background: RA is a global chronic inflammatory disease that marked by chronic progressive synovitis and irreversible joint abnormalities. Methods: The targets of the herb pair and RA were predicted from databases and screened through cross-analysis
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The Potential Association of TFR1/SLC11A2/GPX4 with Ferroptosis in Mediating Lipid Metabolism Disorders in Atherosclerosis Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-12 Yuan Cao, Nan Song, Ying Wang, Xue Leng, Qun Wang, Yixin Ma, Si Chen, Xing Ju, Lianqun Jia
Purpose: Atherosclerosis is the most common and significant form of arterial disease, characterized primarily by lipid accumulation and inflammatory cell infiltration as its main pathological basis. This study aims to investigate the molecular mechanisms and associated pathways by which iron accumulation may be involved in lipid metabolism abnormalities in atherosclerotic mice. Methods: Relying on
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Total Glucosides of Paeony Induce Mitochondrial Dysfunction and Apoptosis by Promoting the Degradation of α5-nAChR in Melanoma Cells Comb. Chem. High Throughput Screen. (IF 1.8) Pub Date : 2024-01-12 Xianguang Meng, Ling Cheng, Jing Jiao, Yuanxin Xing, Li Zhang
background: Malignant melanoma is the leading cause of skin cancer-related death with high malignancy and rapid progression. Total glucosides of paeony (TGP) is extracted from the roots of Paeonia Lactiflora Pall and widely used in the treatment of chronic hepatitis, rheumatoid arthritis, and adjuvant therapy of tumor chemotherapy. Methods: In the present research, M14 and A375 cells were treated with