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Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1 Pharm. Res. (IF 3.7) Pub Date : 2024-03-14 Naomi Fukazawa, Tomohiro Nishimura, Keisuke Orii, Saki Noguchi, Masatoshi Tomi
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Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs Pharm. Res. (IF 3.7) Pub Date : 2024-03-12 Kohei Nakamura, Atsushi Kambayashi, Satomi Onoue
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When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers? Pharm. Res. (IF 3.7) Pub Date : 2024-03-12 Yunjiao Wu, Karel Allegaert, Robert B. Flint, Sebastiaan C. Goulooze, Pyry A. J. Välitalo, Matthijs de Hoog, Hussain Mulla, Catherine M. T. Sherwin, Sinno H. P. Simons, Elke H. J. Krekels, Catherijne A. J. Knibbe, Swantje Völler
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Healthcare Systems and Artificial Intelligence: Focus on Challenges and the International Regulatory Framework Pharm. Res. (IF 3.7) Pub Date : 2024-03-05 Alessia Romagnoli, Francesco Ferrara, Roberto Langella, Andrea Zovi
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Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms Pharm. Res. (IF 3.7) Pub Date : 2024-03-05 Chaozhuang Shen, Hongyi Yang, Wenxin Shao, Liang Zheng, Wei Zhang, Haitang Xie, Xuehua Jiang, Ling Wang
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Clinical Investigation of Large Volume Subcutaneous Delivery up to 25 mL for Lean and Non-Lean Subjects Pharm. Res. (IF 3.7) Pub Date : 2024-03-05 Xiangnan Dang, Han Shih, Rakesh Sharma, Daneen T. Angwin-Kaerner, Kathleen Lin, Shiven Kapur, Nagarajan R. Thyagarajapuram, Galen H. Shi, David S. Collins
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Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease Pharm. Res. (IF 3.7) Pub Date : 2024-03-05 Da Sun, Wenyu Sun, Song-Qi Gao, Jonathan Lehrer, Hong Wang, Ryan Hall, Zheng-Rong Lu
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A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution Pharm. Res. (IF 3.7) Pub Date : 2024-03-05
Abstract Purpose Hollow-type microneedles (hMNs) are a promising device for the effective administration of drugs into intradermal sites. Complete insertion of the needle into the skin and administration of the drug solution without leakage must be achieved to obtain bioavailability or a constant effect. In the present study, several types of hMN with or without a rounded blunt tip micropillar, which
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Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng Pharm. Res. (IF 3.7) Pub Date : 2024-02-21 Ying Yu, Li Yun Wang, Yan Chi Liu, Hao Cui, Cheng Yuan, Cheng Xiao Wang
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Research Landscape of Physiologically Based Pharmacokinetic Model Utilization in Different Fields: A Bibliometric Analysis (1999–2023) Pharm. Res. (IF 3.7) Pub Date : 2024-02-21
Abstract Purpose The physiologically based pharmacokinetic (PBPK) modeling has received increasing attention owing to its excellent predictive abilities. However, there has been no bibliometric analysis about PBPK modeling. This research aimed to summarize the research development and hot points in PBPK model utilization overall through bibliometric analysis. Methods We searched for publications related
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An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat Pharm. Res. (IF 3.7) Pub Date : 2024-02-21 Freddy Arce, Yue Schuman, John Gawel, Robert Garmise, Admassu Abebe, Divyakant Desai
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Antibody-Drug Conjugate Overview: a State-of-the-art Manufacturing Process and Control Strategy Pharm. Res. (IF 3.7) Pub Date : 2024-02-17 Meng Li, Xueyu Zhao, Chuanfei Yu, Lan Wang
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Co-delivery of Brinzolamide and Timolol from Micelles-laden Contact Lenses: In vitro and In Vivo Evaluation Pharm. Res. (IF 3.7) Pub Date : 2024-02-16 Hongyu Yang, Faxing Zhang, Yingzhen Fan, Jian Zhang, Ting Fang, Dandan Xing, Yanli Zhen, Zhihao Nie, Yaming Liu, Dongkai Wang, Ji Li
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Medicinal Polypharmacology in the Clinic – Translating the Polypharmacolome into Therapeutic Benefit Pharm. Res. (IF 3.7) Pub Date : 2024-02-16
Abstract Drugs with multiple targets, often annotated as ‘unselective’, ‘promiscuous’, ‘multitarget’, or ‘polypharmacological’, are widely considered in both academic and industrial research as a high risk due to the likelihood of adverse effects. However, retrospective analyses have shown that particularly approved drugs bear rich polypharmacological profiles. This raises the question whether our
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Convolutional Neural Networks Guided Raman Spectroscopy as a Process Analytical Technology (PAT) Tool for Monitoring and Simultaneous Prediction of Monoclonal Antibody Charge Variants Pharm. Res. (IF 3.7) Pub Date : 2024-02-16 Nitika Nitika, B. Keerthiveena, Garima Thakur, Anurag S. Rathore
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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD) Pharm. Res. (IF 3.7) Pub Date : 2024-02-13
Abstract Purpose This study was designed to verify a virtual population representing patients with nonalcoholic fatty liver disease (NAFLD) to support the implementation of a physiologically based pharmacokinetic (PBPK) modeling approach for prediction of disease-related changes in drug pharmacokinetics. Methods A virtual NAFLD patient population was developed in GastroPlus (v.9.8.2) by accounting
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In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules Pharm. Res. (IF 3.7) Pub Date : 2024-02-13 Daniel Sebastia-Saez, Guoping Lian, Tao Chen
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Monte Carlo Optimization Method Based QSAR Modeling of Placental Barrier Permeability Pharm. Res. (IF 3.7) Pub Date : 2024-02-09 Predrag Vukomanović, Milan Stefanović, Jelena Milošević Stevanović, Aleksandra Petrić, Milan Trenkić, Lazar Andrejević, Milan Lazarević, Danka Sokolović, Aleksandar M. Veselinović
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Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule Pharm. Res. (IF 3.7) Pub Date : 2024-02-09 Qiannan Yang, Tingting Zhang, Yujie Wu, Qianyue Liang, Wanqi Zhao, Rui Liu, Xin Jin
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Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles Pharm. Res. (IF 3.7) Pub Date : 2024-02-08 Jihui Lee, Malene A. Neustrup, Bram Slütter, Conor O’Mahony, Joke A. Bouwstra, Koen van der Maaden
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Structure Based Machine Learning Prediction of Retention Times for LC Method Development of Pharmaceuticals Pharm. Res. (IF 3.7) Pub Date : 2024-02-08 Jonathan Fine, Amanda K. Peterson Mann, Pankaj Aggarwal
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Unraveling Pre-filled Syringe Needle Clogging: Exploring a Fresh Outlook Through Innovative Techniques Pharm. Res. (IF 3.7) Pub Date : 2024-02-07
Abstract Objective This study aimed to investigate the movement of liquid in the needle region of staked-in-needle pre-filled syringes using neutron imaging and synchrotron X-ray tomography. The objective was to gain insights into the dynamics of liquid presence and understand the factors contributing to needle clogging. Methods Staked-in-needle pre-filled syringes were examined using neutron radiography
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Characterization of mRNA Lipid Nanoparticles by Electron Density Mapping Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm Pharm. Res. (IF 3.7) Pub Date : 2024-02-07 Huy M. Dao, Khaled AboulFotouh, Aasim Faheem Hussain, Alexander E. Marras, Keith P. Johnston, Zhengrong Cui, Robert O. Williams
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Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice Pharm. Res. (IF 3.7) Pub Date : 2024-02-01
Abstract Purpose Green tea is a widely consumed beverage. A recent clinical study reported green tea decreased systemic exposure of raloxifene and its glucuronide metabolites by 34–43%. However, the underlying mechanism(s) remains unknown. This study investigated a change in raloxifene’s solubility as the responsible mechanism. Methods The effects of green tea extract, (–)-epigallocatechin gallate
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WANTED DEAD OR ALIVE: New Thinking to Incentivize Drug Development Pharm. Res. (IF 3.7) Pub Date : 2024-01-30 Michael S. Kinch
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Novel Pharmaceutical Cocrystals of Tegafur: Synthesis, Performance, and Theoretical Studies Pharm. Res. (IF 3.7) Pub Date : 2024-01-30
Abstract Purpose Tegafur (TF) is one of the most important clinical antitumor drugs with poor water solubility, severely reducing its bioavailability. This work develops new cocrystals to improve the solubility of TF and systematically investigates the intermolecular interactions to provide new insights into the formation of cocrystal and changes in physicochemical properties. Method In this paper
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Coupling Drug Dissolution with BCS Pharm. Res. (IF 3.7) Pub Date : 2024-01-30 Antony Simitopoulos, Athanasios Tsekouras, Panos Macheras
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The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking Pharm. Res. (IF 3.7) Pub Date : 2024-01-30 Meng-Jia Jin, Xin-Zhe Ge, Qiong Huang, Jia-Wei Liu, Rahul G. Ingle, Dong Gao, Wei-Jie Fang
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Keratinocyte Exosomes for Topical Delivery of Tofacitinib in Treatment of Psoriasis: an In Vitro/ In Vivo Study in Animal Model of Psoriasis Pharm. Res. (IF 3.7) Pub Date : 2024-01-23
Abstract Introduction Exosomes are extracellular vesicles in the range of 40-150 nm released from the cell membrane. Exosomes secreted by keratinocytes can communicate with other keratinocytes and immune cells with specific biomarkers at their surface, which may be effective on inflammation of psoriasis and its pathogenesis. Objective The present study aimed to formulate and study effectiveness of
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Time-Lapse Macro Imaging with Dissolution Tests for Exploring the Interrelationship Between Disintegration and Dissolution Behaviors of Solid Dosages Pharm. Res. (IF 3.7) Pub Date : 2024-01-19 Yichen Yang, Jiajia Gengji, Tao Gong, Zhirong Zhang, Li Deng
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Development of an Accelerated Rotator-based Drug Release Method for the Evaluation of Bupivacaine Multivesicular Liposomes Pharm. Res. (IF 3.7) Pub Date : 2024-01-11 Ziyun Xia, Minzhi Yu, Yayuan Liu, Wenmin Yuan, Yan Wang, Xiaoming Xu, Jungeun Bae, Anna Schwendeman
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IVIVC Revised Pharm. Res. (IF 3.7) Pub Date : 2024-01-08 Nikolaos Alimpertis, Antony Simitopoulos, Athanasios A. Tsekouras, Panos Macheras
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The Osmolality and Hemolysis of High-Concentration Monoclonal Antibody Formulations Pharm. Res. (IF 3.7) Pub Date : 2024-01-03 Meng-Juan Pang, Meng-Wen Wang, Li-Fei Mao, Ze Guo, Ci Qian, Xiao-He Zheng, Wei-Jie Fang
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Correction: Effect of Buffer Salts on Physical Stability of Lyophilized and Spray-Dried Protein Formulations Containing Bovine Serum Albumin and Trehalose Pharm. Res. (IF 3.7) Pub Date : 2023-12-29 Tarun Tejasvi Mutukuri, Jing Ling, Yong Du, Yongchao Su, Qi Tony Zhou
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Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model Pharm. Res. (IF 3.7) Pub Date : 2023-12-29 Manfred Bodenlenz, Thean Yeoh, Gabriel Berstein, Thomas Birngruber, Shibin Mathew, Jaymin Shah, Christopher Banfield, Brett Hollingshead, Stefanus J. Steyn, Sarah M. Osgood, Kevin Beaumont, Sonja Kainz, Christian Holeček, Gert Trausinger, Reingard Raml
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An In Silico Platform to Predict Cardiotoxicity Risk of Anti-tumor Drug Combination with hiPSC-CMs Based In Vitro Study Pharm. Res. (IF 3.7) Pub Date : 2023-12-26 Lan Sang, Zhengying Zhou, Shizheng Luo, Yicui Zhang, Hongjie Qian, Ying Zhou, Hua He, Kun Hao
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Impact of Formulation and Microneedle Length on Transdermal Metronidazole Permeation through Microneedle-Treated Skin Pharm. Res. (IF 3.7) Pub Date : 2023-12-22
Abstract Objective This study aimed to determine the impact of formulation (gel vs cream) and microneedle characteristics (length, number) on permeation of metronidazole through excised microneedle-treated skin. The long-term goal is to apply these results towards a pharmacokinetic study in human subjects with diverse skin types, using in vitro flux data to determine dosing conditions and ultimately
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Exploiting Apical Sodium-Dependent Bile Acid Transporter (ASBT)-Mediated Endocytosis with Multi-Functional Deoxycholic Acid Grafted Alginate Amide Nanoparticles as an Oral Insulin Delivery System Pharm. Res. (IF 3.7) Pub Date : 2023-12-19 Maryam Razmjooei, Seyed Mohammad Hashem Hosseini, Gholamhossein Yousefi, Mohammad-Taghi Golmakani, Mohammad Hadi Eskandari
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Application of PAT Probes in Aluminum Phosphate Adjuvant Manufacturing Pharm. Res. (IF 3.7) Pub Date : 2023-12-19 Przemyslaw Kowal, Ginny Fung, Gabriel Gemmiti, Liliana Sampaleanu, James T. Cronin, Marina Kirkitadze
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Integrated Exposure–Response of Dupilumab in Children, Adolescents, and Adults With Atopic Dermatitis Using Categorical and Continuous Efficacy Assessments: A Population Analysis Pharm. Res. (IF 3.7) Pub Date : 2023-12-11 Emily Briggs, Mohamed A. Kamal, Matthew P. Kosloski, Ian Linsmeier, Natalie Jusko, Nancy Dolphin, Jason Chittenden, Eric L. Simpson, Amy S. Paller, Elaine C. Siegfried, Brad Shumel, Noah A. Levit, Ashish Bansal, John D. Davis, Sunny Chapel, David E. Smith, Nidal Huniti
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PBPK/PD Modeling of Nifedipine for Precision Medicine in Pregnant Women: Enhancing Clinical Decision-Making for Optimal Drug Therapy Pharm. Res. (IF 3.7) Pub Date : 2023-12-04 Xinyang Liu, Wei Wang, Jingsi Chen, Dunjin Chen, Yong Tao, Defang Ouyang
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Impact of Processing Methods on the Physico-chemical Properties of Posaconazole Amorphous Solid Dispersions Pharm. Res. (IF 3.7) Pub Date : 2023-12-01 Ru He, Matthew S. Lamm, Andrew Brunskill, Stephanus Axnanda, Yongjun Li
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Professor David E. Smith: A Fearless Scientist and Devoted Mentor Pharm. Res. (IF 3.7) Pub Date : 2023-11-29 Brian Thompson, Kim Brouwer, Reina Bendayan, Maria M. Posada
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General Commentary: A Tribute to Professor Kenneth R. Morris – Scientist, Teacher, Mentor, Friend…and Underappreciated Academic Arborist Pharm. Res. (IF 3.7) Pub Date : 2023-11-28 Peter L. D. Wildfong
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AgNPs-Modified Polylactic Acid Microneedles: Preparation and In Vivo/In Vitro Antimicrobial Studies Pharm. Res. (IF 3.7) Pub Date : 2023-11-20 Wenqin Zhang, Xiaozhen Cai, Xinyi Zhang, Shiqi Zou, Danhong Zhu, Qiulong Zhang, Jianmin Chen
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Comparative Study of Sorption Phenomena Between Three Medications and Syringes Made of Cyclic Olefin Copolymer or Polypropylene Pharm. Res. (IF 3.7) Pub Date : 2023-11-21 Joëlle Claves, Philip Chennell, Yoann Le Basle, Nina Krautwurst, Valérie Sautou
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Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends Pharm. Res. (IF 3.7) Pub Date : 2023-11-17 Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
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Development of Sustained Release System Based on High Water-Absorbable Gel Formation Using Croscarmellose Sodium, Alkaline Excipients and HPMC (ACSH SR System); Novel Application of Croscarmellose Sodium as a Gel Former Pharm. Res. (IF 3.7) Pub Date : 2023-11-14 Masato Gomi, Naoya Mizutani, Ryotaro Senoo, Noriaki Matsubara, Ayahisa Watanabe, Masato Maruyama, Go Kimura, Kazutaka Higaki
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Use of Resonant Acoustic Mixing Technology for Ultra-Low-Dose Blending in a Single-Step Mixing Process Pharm. Res. (IF 3.7) Pub Date : 2023-11-07 Kyle A. Frey, Helen Baker, Dale K. Purcell, Andrew L. Lewis, David A. Engers
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LC–MS Approach to Decipher a Light Chain Chromatographic Peak Splitting of a Monoclonal Antibody Pharm. Res. (IF 3.7) Pub Date : 2023-11-07 Yanjun Liu, Zac VanAernum, Yue Zhang, Xinliu Gao, Mariana Vlad, Bo Feng, Robert Cross, Bruce Kilgore, Alice Newman, Dongdong Wang, Hillary A. Schuessler, Douglas D. Richardson, Jennifer S. Chadwick
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Fabrication and Characterization of Dissolving Microneedles for Transdermal Drug Delivery of Apomorphine Hydrochloride in Parkinson’s Disease Pharm. Res. (IF 3.7) Pub Date : 2023-11-03 Daisuke Ando, Aisa Ozawa, Motoharu Sakaue, Eiichi Yamamoto, Tamaki Miyazaki, Yoji Sato, Tatsuo Koide, Ken-ichi Izutsu
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Pharmaceutical and Immunological Evaluation of Cholera Toxin A1 Subunit as an Adjuvant of Hepatitis B Vaccine Microneedles Pharm. Res. (IF 3.7) Pub Date : 2023-11-01 Jong-Chan Kim, Jung-ah Choi, Hayan Park, Eunji Yang, Shinyoung Noh, Ji-Seok Kim, Moon-Jin Kim, Manki Song, Jung-Hwan Park
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A survey of FDA Approved Monoclonal Antibodies and Fc-fusion Proteins for Manufacturing Changes and Comparability Assessment Pharm. Res. (IF 3.7) Pub Date : 2023-11-01 Zhe Li, Xiulian Du, Yow-Ming C. Wang
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A Stable Irinotecan Liposome with Enhanced Antitumor Activity in a Range of Tumor Models Pharm. Res. (IF 3.7) Pub Date : 2023-11-01 Zhengxing Su, Li Li, Fei Hao, Jinlong Zhao, Ming Li, Xi Zhao, Dong Zhao
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Benchmark Glycan Profile of Therapeutic Monoclonal Antibodies Produced by Mammalian Cell Expression Systems Pharm. Res. (IF 3.7) Pub Date : 2023-11-01 Shen Luo, Baolin Zhang
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Small is Powerful: Demonstration of the Impact of Nanoformed Piroxicam in a Controlled Clinical Study Pharm. Res. (IF 3.7) Pub Date : 2023-11-01 Satu Lakio, David J. Smith, Goncalo Andrade, Niklas Sandler, Philip Evans, John McDermott, Chris Roe, Edward Hӕggström
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Validation of Anti-Adeno Associated Virus Serotype rh10 (AAVrh.10) Total and Neutralizing Antibody Immunogenicity Assays Pharm. Res. (IF 3.7) Pub Date : 2023-10-25 Elizabeth Butala-Flores, Thien Nguyen, Nithya Selvan, Luke Armstrong, Michelle Miller, Lynn Kamen, Todd Lester, Roman Wernyj, Richie Khanna, Jim McNally, Amanda Hays
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Effect of Food Viscosity on Drug Dissolution Pharm. Res. (IF 3.7) Pub Date : 2023-10-26 Rika Hirose, Kiyohiko Sugano
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Examination of the Rate and Extent of Drug Released from Commercial Topical Delivery Systems During Wear: An Example with Lidocaine Topical Systems Pharm. Res. (IF 3.7) Pub Date : 2023-10-17 Qing Cai, Armita Azarpanah, Jayshil A. Bhatt, Hui Wei, Jamie Carr, Kenneth R. Morris, Caroline Strasinger, Nicole K. Brogden
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Hydration Mechanism and Its Effect on the Solubility of Aripiprazole Pharm. Res. (IF 3.7) Pub Date : 2023-10-13 Zhixin Zheng, Xin Huang, Na Wang, Ting Wang, Lina Zhou, Zhao Xu, Guibin Chen, Wan Cao, Hongxun Hao