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From Conventional to Novel Drug Delivery Systems for Meloxicam: A Systematic Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-02-01 Manjusha Annaji, Nur Mita, Jessica Heard, Xuejia Kang, Ishwor Poudel, Sai H.S. Boddu, Amit K. Tiwari, R. Jayachandra Babu
Meloxicam, a selective COX-2 inhibitor, has demonstrated clinical effectiveness in managing inflammation and acute pain. Although available in oral formulations such as capsules, tablets, and suspension, frequent administration is necessary to maintain therapeutic efficacy, which can increase adverse effects and patient non-compliance. To address these issues, several sustained drug delivery strategies
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A Path of Novelty from Nanoparticles to Nanobots: Theragnostic Approach for Targeting Cancer Therapy Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Gursharanpreet Kaur, Bhawna Khanna, Mohammed Yusuf, Akanksha Sharma, Akhil Khajuria, Hema K. Alajangi, Pradeep K. Jaiswal, Mandip Sachdeva, Ravi Pratap Barnwal, Gurpal Singh
Pharmaceutical development of cancer therapeutics is a dynamic area of research. Even after decades of intensive work, cancer continues to be a dreadful disease with an ever-increasing global incidence. The progress of nanotechnology in cancer research has overcome inherent limitations in conventional cancer chemotherapy and fulfilled the need for target-specific drug carriers. Nanotechnology uses
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Nanotechnology-Based Approaches for Cosmeceutical and Skin Care: A Systematic Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Shital Rani, Piyush Dey, Kritika Pruthi, Sahajdeep Singh, Shivansh Mahajan, Hema K. Alajangi, Sumeet Kapoor, Ankur Pandey, Dikshi Gupta, Ravi Pratap Barnwal, Gurpal Singh
Cosmeceuticals have gained great importance and are among the top-selling products used for skin care. Because of changing lifestyles, climate, and increasing pollution, cosmeceuticals are utilized by every individual, thereby making cosmeceuticals a fruitful field for research and the economy. Cosmeceuticals provide incredibly pleasing aesthetic results by fusing the qualities of both cosmetics and
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Advances in Gold nanoparticles: Synthesis, Functionalization Strategies and Theranostic Applications in Cancer Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Mansi Damani, Mrunal Jadhav, Rashmi Joshi, Bheeshma Pratap Singh, Munira Momin, Raghumani S Ningthoujam, Tabassum Khan
Cancer is among the leading causes of mortality and morbidity in the world. Metallic nanoparticles, especially gold nanoparticles have emerged to be attractive systems to circumvent the associated adverse effects. By the virtue of their unique properties of tunable size, shape, composition, optical properties, biocompatibility, minimal toxicity, multivalency, fluorescence-luminescence property and
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Non-Invasive Delivery of Insulin for Breaching Hindrances against Diabetes Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Manoj Sarangi, Sasmita Padhi, Goutam Rath
Insulin is recognized as a crucial weapon in managing diabetes. Subcutaneous (s.c.) injections are the traditional approach for insulin administration, which usually have many limitations. Numerous alternative (non-invasive) slants through different routes have been explored by the researchers for making needle-free delivery of insulin for attaining its augmented absorption as well as bioavailability
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Targeting Pathways and Integrated Approaches to Treat Rheumatoid Arthritis Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Shradha Devi Dwivedi, Krishna Yadav, Anita Bhoi, Keshav Kant Sahu, Neelam Sangwan, Deependra Singh, Manju Rawat Singh
Rheumatoid arthritis (RA) is a chronic symmetrical systemic disorder that not only affects joints but also other organs such as heart, lungs, kidney, and liver. Approximately there is 0.5%−1% of the total population affected by RA. RA pathogenesis still remains unclear due to which its appropriate treatment is a challenge. Further, multitudes of factors have been reported to affect its progression
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Plant-Based Approaches for Rheumatoid Arthritis Regulation: Mechanistic Insights on Pathogenesis, Molecular Pathways, and Delivery Systems Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Anita Bhoi, Shradha Devi Dwivedi, Deependra Singh, S. Keshavkant, Manju Rawat Singh
Rheumatoid arthritis (RA) is classified as a chronic inflammatory autoimmune disorder, associated with a varied range of immunological changes, synovial hyperplasia, cartilage destructions, as well as bone erosion. The infiltration of immune-modulatory cells and excessive release of proinflammatory chemokines, cytokines, and growth factors into the inflamed regions are key molecules involved in the
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Three-Dimensional Printing as a Progressive Innovative Tool for Customized and Precise Drug Delivery Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Kirti Aggarwal, Kalpana Nagpal
While using three-dimensional printing, materials are deposited layer by layer in accordance with the digital model created by computer-aided design software. Numerous research teams have shown interest in this technology throughout the last few decades to produce various dosage forms in the pharmaceutical industry. The number of publications has increased since the first printed medicine was approved
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Stability Challenges of Amorphous Solid Dispersions of Drugs: A Critical Review on Mechanistic Aspects Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Muralidhar Pisay, Singh Padya, Srinivas Mutalik, Kunnatur B. Koteshwara
The most common drawback of the existing and novel drug molecules is their low bioavailability because of their low solubility. One of the most important approaches to enhance the bioavailability in the enteral route for poorly hydrophilic molecules is amorphous solid dispersion (ASD). The solubility of compounds in amorphous form is comparatively high because of the availability of free energy produced
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Pharmaceutical In Situ Gel for Glaucoma: Recent Trends and Development with an Update on Research and Patents Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Rohitas Deshmukh, Rajesh Singh, Sakshi Mishra
Glaucoma is a progressive visual polyneuropathy characterized by retinal ganglion cell atrophy and optic nerve head changes. It's generally triggered due to increased intraocular pressure compared with the healthy eye. Glaucoma is treated with various medications in traditional eye drops, such as prostaglandins, carbonic anhydrase inhibitors, beta-blockers, and others. Such treatments are difficult
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Targeting Amyloids with Coated Nanoparticles: A Review on Potential Combinations of Nanoparticles and Bio-Compatible Coatings Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Oshin D. Warerkar, Niyati H. Mudliar, Munira M. Momin, Prabhat K. Singh
Amyloidosis is the major cause of many neurodegenerative diseases, such as, Alzheimer's and Parkinson's where the misfolding and deposition of a previously functional protein make it inept for carrying out its function. The genesis of amyloid fibril formation and the strategies to inhibit it have been studied extensively, although some parts of this puzzle still remain unfathomable to date. Many classes
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Copper Nanoclusters as Novel Podium for Cancer Detection, Imaging, and Therapy Applications Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Ranjita Misra, A. Sivaranjani, Suraiya Saleem, Bignya Rani Dash
Nanoclusters (NCs) are meticulously small, kinetically stable, crystalline materials which hold immense potential as multifaceted catalysts for a broad range of biomedical applications. Metal NCs are atomically precise and exist within the range of Fermi wavelength of electrons. They are highly advantageous as functional materials as their physicochemical properties can be customized to meet specific
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Current Insights into Targeting Strategies for the Effective Therapy of Diseases of the Posterior Eye Segment Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Prachi Pimple, Apurva Sawant, Sujit Nair, Sujata P. Sawarkar
The eye is one a unique sophisticated human sense organ with a complex anatomical structure. It is encased by variety of protective barriers as responsible for vision. There has been a paradigm shift in the prevalence of several major vision threatening ocular conditions with enhanced reliance on computer-based technologies in our workaday life and work-from-home modalities although aging, pollution
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Novel Strategies Using Sagacious Targeting for Site-Specific Drug Delivery in Breast Cancer Treatment: Clinical Potential and Applications Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Pedram Ebrahimnejad, Zahra Mohammadi, Amirhossein Babaei, Melika Ahmadi, Shervin Amirkhanloo, Kofi Asare-Addo, Ali Nokhodchid
For more than a decade, researchers have been working to achieve new strategies and smart targeting drug delivery techniques and technologies to treat breast cancer (BC). Nanotechnology presents a hopeful strategy for targeted drug delivery into the building of new therapeutics using the properties of nanomaterials. Nanoparticles are of high regard in the field of diagnosis and the treatment of cancer
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Advanced Technologies of Drug Delivery to the Posterior Eye Segment Targeting Angiogenesis and Ocular Cancer Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Mudassir Ansari, Yogesh A. Kulkarni, Kavita Singh
Retinoblastoma (RB), a childhood retinal cancer is caused due to RB1 gene mutation which affects the child below 5 years of age. Angiogenesis has been proven its role in RB metastasis due to the presence of vascular endothelial growth factor (VEGF) in RB cells. Therefore, exploring angiogenic pathway by inhibiting VEGF in treating RB would pave the way for future treatment. In preclinical studies,
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Applications of Cannabinoids in Neuropathic Pain: An Updated Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2024-01-01 Peggy Arthur, Anil Kumar Kalvala, Sunil Kumar Surapaneni, Mandip Sachdeva Singh
Neuropathic pain is experienced due to injury to the nerves, underlying disease conditions or toxicity induced by chemotherapeutics. Multiple factors can contribute to neuropathic pain such as central nervous system (CNS)-related autoimmune and metabolic disorders, nerve injury, multiple sclerosis and diabetes. Hence, development of pharmacological interventions to reduce the drawbacks of existing
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Exploring the Therapeutic Potential of Anticancer Heterocyclic Compounds: Role in Nanoscale Pharmacotherapy Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Lalit Kumar, Shivani Verma, Kajal Joshi, Sumit Sharma
There are a large number of pharmaceutical products in the market containing heterocyclic compounds. Heterocyclic compounds are explored in the field of therapeutics due to their unique physicochemical and pharmacological properties. A large number of heterocyclic compounds existing in the pharmaceutical market have marked anticancer activity and many of them are under research investigations to treat
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Impact of Nanotechnology on Differentiation and Augmentation of Stem Cells for Liver Therapy Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Ifrah Anwar, Usman Ali Ashfaq
The liver is one of the crucial organs of the body that performs hundreds of chemical reactions needed by the body to survive. It is also the largest gland of the body. The liver has multiple functions, including the synthesis of chemicals, metabolism of nutrients, and removal of toxins. It also acts as a storage unit. The liver has a unique ability to regenerate itself, but it can lead to permanent
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A Narrative Review on Non-Invasive Drug Delivery of Teriparatide: A Ray of Hope Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Neeraj Mittal, Gajanand Sharma, Om Parkash Katare, Sanjay Kumar Bhadada
In the field of pharmaceutical biotechnology and formulation development, various protein and peptide-based drugs have been used for therapeutic and clinical implications. These are mainly given via parenteral routes like intravenous, subcutaneous or intramuscular delivery. Teriparatide, also known as PTH 1-34, is a U.S. Food & Drug Administartion− approved anabolic drug to treat osteoporosis is currently
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Advances in Current Drugs and Formulations for the Management of Atopic Dermatitis Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Keerthi Atluri, Srikanth Manne, Vijendra Nalamothu, Alon Mantel, Purnendu K. Sharma, R. Jayachandra Babu
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with a complex pathophysiology. Treatment of AD remains challenging owing to the presence of a wide spectrum of clinical phenotypes and limited response to existing therapies. However, recent genetic, immunological, and pathophysiological insights into the disease mechanism resulted in the invention of novel therapeutic drug candidates
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Recent Advances in Teriparatide Delivery by-virtue-of Novel Drug Delivery Approaches for the Management of Osteoporosis Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Sagar Salave, Dhwani Rana, Kedar Prayag, Srushti Shah, Garima Rawat, Nitish Sharma, Anil B. Jindal, Rikin Patel, Derajram Benival
Osteoporosis is a bone incapacitating malady which globally accounts for over hundred million fractures annually. Therapeutic interventions for management of osteoporosis are divided as antiresorptive agents and osteoanabolic agents. Teriparatide is the only osteoana-bolic peptide which is available world-wide for the treatment of osteoporosis. It is administered as a daily subcutaneous injection for
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Exosomes: Recent Advances and Challenges as Targeted Therapeutic Delivery Vesicles Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Sourabh Jadhav, Ankaj Kumar, Arvind Gulbake
The exosome is a naturally derived nanostructured lipid vesicle that ranges from 40−100 nm in size and is utilized to transport drugs, and biological macromolecules, including therapeutic RNA and proteins. It is a membrane vesicle actively released by cells to transport cellular components with a purpose for biological events. The conventional isolation technique has several drawbacks, including low
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Nanotherapeutic Approach to Delivery of Chemo- and Gene Therapy for Organ-Confined and Advanced Castration-Resistant Prostate Cancer Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Satish Sharma, Supriya D. Mahajan, Kent Chevli, Stanley A. Schwartz, Ravikumar Aalinkeel
Treatments for late-stage prostate cancer (CaP) have not been very successful. Frequently, advanced CaP progresses to castration-resistant prostate cancer (CRPC), with 50#37;-70% of patients developing bone metastases. CaP with bone metastasis-associated clinical complications and treatment resistance presents major clinical challenges. Recent advances in the formulation of clinically applicable nanoparticles
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Theranostic Approach for the Management of Osteoporosis Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Anjali Pant, Joga Singh, Ravi Pratap Barnwal, Gurpal Singh, Bhupinder Singh
Osteoporosis (OP) is a bone-metabolic disorder, causing micro-architecture degeneration and a decrease in bone density. Nutritional deficiency, i.e., calcium, vitamin D, and hormonal imbalances are the primary cause for the occurrence of OP. Although conventional diagnostic techniques and therapies are available and found to be effective only at a later stage, though still lack prevention strategies
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Lignin-Based Nanomaterials as Drug Delivery Vehicles: A Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Tahmidul Islam Aquib
Over the past decade, lignin-based nanomaterials have astonishingly gained tremendous popularity among researchers worldwide for utilization in various high-value added fields. However, the copiousness of published articles suggests that lignin-based nanomaterials are currently being given the most priority as drug delivery vehicles or drug carriers. A large number of reports have been published during
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An Overview on Macrophage Targeting: A Promising Approach Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Venkata Deepthi Vemuri, Rekharani Kushwaha, Gollu Gowri, Nalini Mathala, Swathi Nalla, Sasikala Allam, Gurijala Lekhya
Macrophages are immuno cells with high flexibility among hematopoietic system. Macrophages are tangled with many diseases like chronic inflammatory, atherosclerosis, autoimmune, and cancer. Macrophages play a major role in developing the inflammation and meanwhile resolving the damage occurred during these disease conditions. Therefore, the use of macrophages in targeted drug delivery appeared to be
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Exploring the Therapeutic Potential of Cyclosporine for Ophthalmic Indications by Novel Carrier Systems Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Garima Rawat, Shital Kolhe, Dhwani Rana, Sagar Salave, Derajram Benival
Cyclosporine (CsA) stays the most intangible molecule holding a good history for treating several ophthalmic conditions and it even attributes to multiple off-label uses. Topical delivery of CsA is the most preferred route but owing to the molecule's physicochemical properties such as poor aqueous solubility and high molecular weight as well as its encounter with multiple barriers of eye causes hindrance
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Implementation of Quality by Design in the Formulation and Development of Nanocarrier-Based Drug Delivery Systems Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Sonal Mehrotra, Salwa, Lalit Kumar
Quality by design (QbD) has recently fascinated researchers for utilizing it in various arenas of pharma trends. By overcoming the conventional process, QbD prevents the risk of errors caused by the 'guess and by god approach'. This framework fosters profound knowledge of product and process quality by implying sound science and risk assessment strategies. The virtue of QbD leads to the collaborative
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[Novel strategies using sagacious targeting for site-specific drug delivery in breast cancer treatment: Clinical potentials and applications] Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-12-01 Pedram Ebrahimnejad, Zahra Mohammadi, Melika Ahmadi, Shervin Amirkhanloo, Amirhossein Babaei, Kofi Asare-Addo, Ali Nokhodchi
For more than a decade, researchers have been working to achieve new strategies and smart targeting drug delivery techniques and technologies to treat breast cancer. Nanotechnology presents a hopeful strategy for targeted drug delivery into the building of new therapeutics using the properties of nanomaterials. Nanoparticles are of a high regard in the field of diagnosis and the treatment of cancer
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Recent Advances and Prospects for Plant Gum-Based Drug Delivery Systems: A Comprehensive Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Minkal Tuteja, Kalpana Nagpal
This work is an effort to first introduce plant-based gums and discussing their drug delivery applications. The composition of these plant gums and their major characteristics, which make them suitable as pharmaceutical excipients are also described in detail. The various modifications methods such as physical and chemical modifications of gums and polysaccharides have been discussed along with their
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A Review on Recent Advances in Mannose-Functionalized Targeted Nanocarrier Delivery Systems in Cancer and Infective Therapeutics Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Vasanti Suvarna, Niserga Sawant, Namita Desai
Unmodified nanocarriers used in the chemotherapy of cancers and various infectious diseases exhibit prolonged blood circulation time, prevent enzymatic degradation and increase chemical stability of encapsulated therapeutics. However, off-target effect and lack of specificity associated with unmodified nanoparticles (NPs) limit their applications in the health care system. Mannose (Man) receptors with
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Cyclodextrin-Based Arsenal for Anti-Cancer Treatments Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Hitesh Chopra, Ravinder Verma, Sakshi Kaushik, Jatin Parashar, Kumud Madan, Afsareen Bano, Rashmi Bhardwaj, Parijat Pandey, Beena Kumari, Deepika Purohit, Manish Kumar, Saurabh Bhatia, Md. Habibur Rahman, Vineet Mittal, Inderbir Singh, Deepak Kaushik
Anti-cancer drugs are mostly limited in their use due to poor physicochemical and biopharmaceutical properties. Their lower solubility is the most common hurdle limiting their use upto their potential. In the recent years, the cyclodextrin (CD) complexation have emerged as existing approach to overcome the problem of poor solubility. CD-based nano-technological approaches are safe, stable and showed
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Peptides as Diagnostic, Therapeutic, and Theranostic Tools: Progress and Future Challenges Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Reena Thakur, Chander Raman Suri, Indu Pal Kaur, Praveen Rishi
Peptides are emerging as a promising candidate for therapeutic as well as diagnostic applications within the domain of clinical and scientific research. They are recognized for being highly selective, sensitive and efficacious with minimal or no toxicity. Small size, non-immunogenicity, ease of synthesis and huge scope of modification are some of the well-established properties of peptides, which make
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Armamentarium in Drug Delivery for Colorectal Cancer Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2023-01-01 Asad Ali, Juber Akhtar, Usama Ahmad, Abdul Samad Basheer, Neha Jaiswal, Afroz Jahan
Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States. However, more than half of all incidence and mortality are caused by risk factors such as smoking, unhealthy diet, excessive alcohol consumption, inactivity, and excess weight, and thus can be protected. CRC morbidity and mortality can also be reduced by proper screening and monitoring. Over the last
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Self-Assembly Polymeric Nano Micelles for the Futuristic Treatment of Skin Cancer and Phototoxicity: Therapeutic and Clinical Advancement Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Navneet Mehan, Manish Kumar, Shailendra Bhatt, Ravi Shankar, Beena Kumari, Rakesh Pahwa, Deepak Kaushik
In the last few years, the polymeric micelles played a major role as a drug carrier in nano-sized drug delivery system. The polymeric micelles are designed from synthetic block co-polymers and graft copolymers. In the mixed micelles, the bilayer lipid membrane and surfactants are used. Both micelles are in nano-sized and used to enhance the drug delivery to treat different diseases. In this review
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Recent Progress in Self-Emulsifying Drug Delivery Systems: A Systematic Patent Review (2011-2020) Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Pedro Sebastián Londoño Ruiz, Mairim Russo Serafini, Izabel Almeida Alves, Diana Marcela Aragón Novoa
Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim of this review is to discuss the state of the art of patents for this drug delivery system by studying recent patent applications (2011 to 2020). We
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The Role of Polymers and Excipients for Better Gastric Retention of Captopril Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Uddipta Das, Pankaj Wadhwa, Pankaj Kumar Singh, Dheeraj Varma Kalidindi, Kalpana Nagpal
Captopril is an angiotensin-converting enzyme (ACE) inhibitor that prevents angiotensin I (ATI) from being converted to angiotensin II (ATII). However, it offers certain limitations like instability, dose dumping and burst release due to its usage in the native state. In the last two decades, different polymers and excipients have been used to make captopril more accessible and well-accepted. The present
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Grafting of Natural Polymers and Gums for Drug Delivery Applications: A Perspective Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Baburao N. Chandakavathe, Ravindra G. Kulkarni, Shivsharan B. Dhadde
Natural polymers have received more attention because of their advantages over synthetic polymers such as abundant availability, low cost, biodegradability and non-toxicity. However, natural polymers suffer some limitations such as drop-in viscosity upon storage, uncontrolled hydration, solubility, inability to perform under high temperature and pressure (thermal stability), etc. In many instances
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Polymeric Nanoparticles: A Holistic Approach to Combat Tuberculosis Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Sarita Rani, Ashok Kumar Sharma, Raghu Kasu, Umesh Gupta
The emergence of multidrug-resistant (MDR) and extremely drug resistant (XDR) forms of pulmonary tuberculosis (TB) remains a major health challenge in this advanced era of health science. The longer therapy and higher dose of anti-tubercular drugs (ATDs) increases the patient incompliance at its peak levels of intolerance as well as toxicity. In the recent decades, nanoparticulate drug delivery has
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Receptor-Targeted Surface-Engineered Nanomaterials for Breast Cancer Imaging and Theranostic Applications Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Javed Ahmad, Md. Rizwanullah, Teeja Suthar, Hassan A. Albarqi, Mohammad Zaki Ahmad, Parameswara Rao Vuddanda, Mohammad Ahmed Khan, Keerti Jain
Breast cancer is one of the most frequently diagnosed cancers in women and the major cause of worldwide cancer-related deaths among women. Various treatment strategies including conventional chemotherapy, immunotherapy, gene therapy, gene silencing and deliberately engineered nanomaterials for receptor mediated targeted delivery of anticancer drugs, antibodies, and small-molecule inhibitors, etc are
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Exploration of 3D Printing of Anti-Infective Urinary Catheters: Materials and Approaches to Combat Catheter-Associated Urinary Tract Infections (CAUTIs) - A Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Archana Menon, Rubini Durairajan, Ramyadevi Durai, Nithyanand Paramasivam, VedhaHari B. Narayanan
Three-dimensional (3D) printing is a pioneering technology that has gained increased popularity in the fields of tissue engineering, drug design, drug delivery systems and biomedical devices. Thus, it enables us to explore this technique for fabricating 3D-printed catheters. Owing to its enhanced productivity and cost-efficiency, this technique can be utilized to fabricate any material for manufacturing
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Crafting Immunological Response Using Particulate Vaccines Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Amit Bansal, Bernadette D'Souza, Deepak N. Kapoor, Paritosh Singh, Gretchen Starr, Kiran Kumar Muppireddy
To achieve optimal immunogenicity, particulates present a promising vehicle for antigen delivery and have the potential to skew immune response. Particulate vaccine offers several advantages including targeting of antigen to sentinel cells, protection from degradation, sustained release, and itself acts an adjuvant mimics viral structure. Adjuvant presence is vital in overcoming the poor immunogenicity
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Cyclodextrin-Based Supramolecular Ternary Complexes: Emerging Role of Ternary Agents on Drug Solubility, Stability, and Bioavailability Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Pooja Suvarna, Pinal Chaudhari, Shaila A. Lewis
The aqueous solubility of active drug moiety plays a crucial role in the development of an efficacious formulation. The poor aqueous solubility of BCS class II and IV drugs is manifested as poor bioavailability. Preparation of cyclodextrin inclusion complex to improve the solubility, stability, and bioavailability is a well-established technique. The latest trend in cyclodextrin research is focused
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Recent Advancements in Electrospun Nanofibers for Wound Healing: Polymers, Clinical and Regulatory Perspective Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Zeeshan Patel, Sankalp A. Gharat, Moawia M. Al-Tabakha, Akram Ashames, Sai H. S. Boddu, Munira M. Momin
Wound management is an unmet therapeutic challenge and a global healthcare burden. Current treatment strategies provide limited efficiency in wound management, thus undergoing constant evolution in the treatment approaches. As wound healing is a complex physiological process involving precise synchronization of various phases like hemostasis, inflammation and remodelling, which necessitates innovative
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A Review of Anti-Aging Nanoformulations: Recent Developments in Excipients for Nanocosmeceuticals and Regulatory Guidelines Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Vivek Basudkar, Sankalp A. Gharat, Munira M. Momin, Mihika Shringarpure
Skin aging is the progressive biological process generally characterized by the appearance of wrinkles, age spots, sagging of skin, and dryness. Since skin is an essential part of physical appearance, this has led to increased concerns about skincare. Anti-aging products help in improving the quality and health of the skin by nourishing it. However, due to large particle size they are less efficacious
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Immunomodulation and Anticancer Immunity: Reviewing the Potential of Probiotics and Their Delivery with Macromolecular Carriers Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Sanjay Tiwari, Mitesh Dwivedi, Sachin Rathod, Pratap Bahadur
Probiotics colonize in the gastrointestinal tract and regulate the homeostasis in healthy human hosts. These protect the host against putrefactive organisms and secrete soluble factors exhibiting important transductive roles. However, constitutive processes in human host are deregulated following dysbiosis caused during prolonged exposure to cytotoxic agents and pollutants. Apart from restoring the
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Getting into the Brain: Are We in Yet or Just Knocking at the Door? Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Kalpana Nagpal, Dhirender Singh, Amit Bhatia, Pradeep Kumar
Nanomedicine, a promising addition to the spectrum of biomedicine, has viewed countless breakthroughs in the implementations of "site-specific" drug delivery. The promises of nanomedicines revolve around their unique physicochemical properties that permit the transport of therapeutics to the desired site of action, improve the pharmacokinetic endpoint, maximize the pharmacological influence of treatment
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Exploring Liposomes for Lung Cancer Therapy Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Aisha Shahid, Mohd Muazzam Khan, Usama Ahmad, Md. Faheem Haider, Asad Ali
Cancer is referred to as a pleiotropic disease-causing approximately 9.6 million deaths in 2018. Among all cancers, lung cancer was the leading cause of death in 2017, and 12% of fatalities were alone due to lung cancer. The associated risk factors in lung cancer include smoking (80-85%), chronic inflammation in the lungs, COPD, pulmonary fibrosis, environmental and occupational exposure to nickel
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A Critical Review on Floating Tablets as a Tool for Achieving Better Gastric Retention Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Anjali Rajora, Kalpana Nagpal
Most of the oral drug delivery systems demand better retention of drug in the gastrointestinal tract (GIT) for better bioavailability. One of the tools for better gastric retention of the drug is to administer it as a floating drug delivery system (FDDS) by reducing its density, compared to the gastric fluids. This system is helpful to overcome the problems associated with the conventional pharmaceutical
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Oral Dispersible Films from Product Development to End-User Acceptability: A Review Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Qurrat-ul-ain Khan, Muhammad Irfan Siddique, Muhammad Sarfraz, Khurram Rehman, Muhammad Farhan Sohail, Haliza Katas
Orodispersible films (ODFs) have served as an emerging platform for the delivery of drugs in a convenient way. They have numerous advantages, the significant one is simplicity of administration for special populations such as pediatric and geriatric as well as patients with swallowing difficulty. Besides, the advantages include accurate dosing and fast action. The ODFs are efficiently designed with
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Challenges and Strategies for Topical and Transdermal Delivery of Bioactive Peptides Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2022-01-01 Antonio Jiménez-Rodríguez, Daniela Guardado-Félix, Marilena Antunes-Ricardo
Bioactive peptides have gained the attention and interest of researchers and the industry for their therapeutic effects and high specificity, thus reducing the risks of side effects and making them an attractive alternatives in developing new biopharmaceuticals or cosmeceuticals. Nevertheless, their incorporation into formulations and administration presents challenges such as low stability under different
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Mesenchymal Stem Cells: From Regeneration to Drug Delivery Systems Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Zeeshan Shaukat, Abdaal Ali, Uzair Ahmed, Muhammad Rizwan Javed, Muhammad Qasim, Muhammad Tariq, Muhammad Rauf Ahmed, Muhammad Masoud
Targeting drug delivery has been a focus of researchers in recent years for cancer and other diseases. Many approaches like liposomes, exosomes, nanoparticles (magnetic), encapsulation etc. have been developed and investigated for their clinical applications. But disadvantages linked to these therapies limit them to be used in clinical settings. Cell based drug delivery systems has emerged as an alternative
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What's New in Allergen Immunotherapy Patents? A Review. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Anamaria Mendonça Santos,Carina Carvalho Dos Santos,Tiago Bittencourt de Oliveira,Mairim Russo Serafini,Izabel Almeida Alves
In recent years, allergies are on the rise. The growth of allergies cases has changed the immune system's response to new pathogens. The therapy used to treat these diseases is based on allergen avoidance, pharmacotherapy and allergen-specific immunotherapy. The last one has received a lot of interest in the research field, due to the possibility of leading the patient to a cure. In this sense, new
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Nanocarriers for Anticancer Drug Targeting: Recent Trends and Challenges. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Sunita Dahiya,Rajiv Dahiya,Eliud Hernández
Nanocarriers are nanostructured vehicles employed to deliver anticancer drugs to the targeted tumor sites in the body. Nanocarriers have been successfully employed to circumvent certain limitations of conventional anticancer drug delivery while providing greater bioavailability, prolonged circulation time and higher tumor accumulation for enhanced therapeutic outcomes in cancer treatment. Nanocarriers
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Understanding Nanotechnology in the Treatment of Oral Cancer: A Comprehensive Review. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Neeraj Taneja,Aftab Alam,Ranjana S Patnaik,Tannu Taneja,Sonia Gupta,Sunil M K
Oral cancer is the 11th most common cancer in the world with a high morbidity rate. Various conventional therapies have been used for the treatment of oral cancer such as surgery, radiotherapy, and chemotherapy used either alone or in combination but these have many limitations, making them unsuitable for treating oral cancer. Nanotechnology has been emerged out as an innovative tool in the field of
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Role of Exosomes for Delivery of Chemotherapeutic Drugs. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Aragaw Gebeyehu,Nagavendra Kommineni,David G Meckes,Mandip Singh Sachdeva
Exosomes are endogenous extracellular vesicles (30-100 nm) composed with membrane lipid bilayer which carry vesicular proteins, enzymes, mRNA, miRNA and nucleic acids. They act as messengers for intra- and inter-cellular communication. In addition to their physiological roles, exosomes have the potential to encapsulate and deliver small chemotherapeutic drugs and biological molecules such as proteins
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Role of Cissus quadrangularis in the Management of Osteoporosis: An Overview. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Jaspreet Kaur,Gajanand Sharma,Akanksha Mahajan,Om Parkash Katare,Sanjay Kumar Bhadada,Gargi Ghoshal
This article aims to provide a comprehensive review of Cissus quadrangularis (CQ), which is a traditional medicinal herb and has a potential osteoprotective effect. CQ is a perennial climber of family Vitaceae that is commonly found in the hotter parts of India. It is most widely used in India for improving bone health and is well known as "hadjod." It shows an anti-osteoporotic effect through different
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Synthesis and Therapeutic Potential of Nanoceria against Cancer: An Update. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Duaa Zahra,Anam Javaid,Mudassir Iqbal,Iqra Akbar,Usman Ali Ashfaq
Applications of nanoceria in the biomedical field are quite promising, as previous data has shown potential use of nanoceria as therapeutics via radical scavenging and oxidative stress mitigating properties. But, still, there are contradicting reports regarding nanoceria activity, mode of action, and in vitro toxicity in the cell. There are different nanoceria synthesis methods and Ligands for functionalization
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Nanoformulations and Highlights of Clinical Studies for Ocular Drug Delivery Systems: An Overview. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Munira M Momin,Shaikh Darakhshan Afreen
Several ocular drug delivery (ODD) systems, like hydrogels, microparticles, nano-emulsions, micro-emulsions, and liposomes have been researched, which can govern the drug release and sustain therapeutic levels for a delayed period in the eye. While new drugs targeting methods to the eye are possible by various nanoparticles. Presently in the market, there are fewer choices and need for novel nano-ocular
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Nanodiamonds: A Versatile Drug-Delivery System in the Recent Therapeutics Scenario. Crit. Rev. Ther. Drug Carr. Syst. (IF 2.7) Pub Date : 2021-01-01 Awesh Yadav,Rahul Shukla,S J S Flora
Nanodiamonds (ND) belong to the nano-carbon family, which involves several synthesis, post-synthesis methods, and other modifications for ND preparation. NDs have played vital role both inside and outside of medicine in recent years. The study of NDs has stated in early 1960s, NDs are smaller particles with a size of about 4-5 nm with confined size distribution, large-scale synthesis at lower costs