样式: 排序: IF: - GO 导出 标记为已读
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Neutrophil accumulation raises defence against Streptococcus equi ssp. zooepidemicus in the absence of Gasdermin D Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-17 Yajuan Li, Zihua Lin, Jingyu Yu, Yuxuan Liu, Shun Li, Yunfei Huang, Oladejo Ayodele Olaolu, Qiang Fu
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Sophoricoside improved Crohn's disease-like colitis by inhibiting intestinal epithelial cell apoptosis through PI3K/AKT signaling Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Qingqing Li, Jing Li, Lixia Yin, Ju Huang, Xinyue Liu, Jinran Shi, Zhijun Geng, Xue Song, Lian Wang, Yueyue Wang, Xiaofeng Zhang, Lugen Zuo, Jianguo Hu
Increased apoptosis of intestinal epithelial cells (IECs) is a significant cause of intestinal barrier dysfunction in Crohn’s disease (CD). Sophoricoside (SOP) is an isoflavone glycoside known for its anti-apoptotic properties. The aim of this study was to investigate the effects of SOP on mice with CD-like colitis and to understand the underlying mechanisms. Mice treated with 2,4,6-trinitrobenzene
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Designing a predictive Framework: Immune-Related Gene-Based nomogram and prognostic model for kidney renal papillary cell carcinoma Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Adrian Lim, Mouad Edderkaoui, Yi Zhang, Qiang Wang, Ruoxiang Wang, Stephen J. Pandol, Yan Ou
Kidney renal papillary cell carcinoma (KIRP) is frequently associated with an unfavorable prognosis for affected individuals. Unfortunately, there has been insufficient exploration in search for a reliable prognosis signature and predictive indicators to forecast outcomes for KIRP patients. The aim of this study is to employ a comprehensive analysis of data for the identification of prognosis genes
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Targeting the “tumor microenvironment”: RNA-binding proteins in the spotlight in colorectal cancer therapy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Yiwei Zhang, Yujun Zhang, Jingjing Song, Xifu Cheng, Chulin Zhou, Shuo Huang, Wentao Zhao, Zhen Zong, Lingling Yang
Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate among cancers. The development of CRC involves both genetic and epigenetic abnormalities, and recent research has focused on exploring the ex-transcriptome, particularly post-transcriptional modifications. RNA-binding proteins (RBPs) are emerging epigenetic regulators that play crucial roles in post-transcriptional
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Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Manling Xie, Zhen He, Bing Bin, Ning Wen, Jihua Wu, Xiaoyong Cai, Xuyong Sun
Hepatic ischaemia–reperfusion injury (HIRI) is a major clinical concern during the perioperative period and is closely associated with early allograft dysfunction (EAD), acute rejection (AR) and long-term graft survival. Neutrophil extracellular traps (NETs) are extracellular structures formed by the release of decondensed chromatin and granular proteins following neutrophil stimulation. There is growing
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Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Nannan Peng, Jingmin Wang, Haimei Zhu, Ziyue Liu, Jiayi Ren, Wenjing Li, Yongzhong Wang
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Prussian blue analogues improves the microenvironment after spinal cord injury by regulating Zn Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Jinpeng Gao, ShuRui Chen, Sen Lin, Xifan Mei
Mitochondrial injury, neuronal apoptosis and phenotypic transformation of macrophages are the main mechanisms of spinal cord injury. Based on the Prussian blue nanomase's strong ability to clear free radicals, the treatment of spinal cord injury with nano-zirconium (Pb–Zr) was carried out. The disease treatment strategy based on nanomaterials has excellent therapeutic effect, and Prussian blue analogs
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Dupilumab therapy improves gut microbiome dysbiosis and tryptophan metabolism in Chinese patients with atopic dermatitis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Liu Yang, Danqi Li, Shuomin Sun, Danping Liu, Yi Wang, Xiaohuan Liu, Bin Zhou, Wenjia Nie, Lu Li, Yifei Wang, Shanshan Sha, Yan Li, Chen Shen, Juan Tao
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Pharmacological inhibition of the ACE/Ang-2/AT1 axis alleviates mechanical ventilation-induced pulmonary fibrosis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Jinhua Feng, Xi Huang, Qiaoyi Xu, Ri Tang, Yang Zhou, Shaojie Qin, Shunpeng Xing, Yuan Gao, Shuya Mei, Zhengyu He
Mechanical ventilation (MV) is an essential therapy for acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. However, it can also induce mechanical ventilation-induced pulmonary fibrosis (MVPF) and the underlying mechanism remains unknown. Based on a mouse model of MVPF, the present study aimed to explore the role of the angiotensin-converting enzyme/angiotensin II/angiotensin type 1
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L-arginine mitigates bleomycin-induced pulmonary fibrosis in rats through regulation of HO-1/PPAR-γ/β-catenin axis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Nabil A. Alhakamy, Abdulmohsin J. Alamoudi, Hani Z. Asfour, Osama A.A. Ahmed, Ashraf B. Abdel-Naim, Esam M. Aboubakr
Pulmonary fibrosis is a chronic and progressively deteriorating lung condition that can be replicated in laboratory animals by administering bleomycin, a chemotherapeutic antibiotic known for its lung fibrosis-inducing side effects. L-arginine, a semi-essential amino acid, is recognized for its diverse biological functions, including its potential to counteract fibrosis. This study aimed to evaluate
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Clinicopathological features and mucosal microbiota in gastric mucosal damage between nodular and non-nodular gastritis in children with Helicobacter pylori infection Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Wei Zheng, Yongjie Gan, Yaofeng Yang, Kerong Peng, Fubang Li, Hong Zhao, Weizhong Gu, Mizu Jiang
Nodular gastritis (NG) represents a frequently observed clinical presentation of () infection in pediatric patients. This investigation aimed to explore the microbiota and histological features of the gastric mucosa in children with colonized NG. The current investigation examined a sample of 120 children who underwent gastroscopy due to symptoms of gastrointestinal distress, which showed that 64 were
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Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Xingliang Qin, Yongyao Tan, Weishu Ren, Weiwei Zhou, Rouxi Niu, Linyue Liang, Jinling Li, Kaiyuan Cao, Guohong Wei, Xun Zhu, Mingxing Huang
Lipocalin 13 (LCN13) is a member of the lipocalin family that consists of numerous secretory proteins. LCN13 high-expression has been reported to possess anti-obesity and anti-diabetic effects. Although metabolic dysfunction-associated steatotic liver diseases (MASLD) including metabolic dysfunction-associated steatohepatitis (MASH) are frequently associated with obesity and insulin resistance, the
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Costunolide mitigates inflammation and promotes extracellualr matrix integrity of thoracic aortic dissection by inhibiting NF-κB signaling Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Tonglei Han, Hanfei Tang, Changpo Lin, Dong Yan, Zhenyu Zhou, Yimin Yang, Liang Cai, Jiaqi Zhu, Bin Gao, Yi Si, Weiguo Fu, Zongguang Tai, Xiao Tang, Daqiao Guo
Thoracic aortic dissection (TAD) is one of the most fatal cardiovascular diseases. One of its important pathological characteristics is the local inflammatory response. Many studies have found that Macrophage polarization plays an extremely critical role in the inflammatory progression and tissue remodeling of TAD. Costunolide (CTD) has an improving effect on oxidative stress and inflammation in the
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The NLRP3 inhibitor, OLT1177 attenuates brain injury in experimental intracerebral hemorrhage Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Mei Fang, Fan Xia, Jiayan Wang, Chengyang Wang, Bang Teng, Shenglan You, Manrui Li, Xiameng Chen, Xin Hu
It has been reported activation of NLRP3 inflammasome after intracerebral hemorrhage (ICH) ictus exacerbates neuroinflammation and brain injury. We hypothesized that inhibition of NLRP3 by OLT1177 (dapansutrile), a novel NLRP3 inflammasome inhibitor, could reduce brain edema and attenuate brain injury in experimental ICH. ICH was induced by injection of autologous blood into basal ganglia in mice models
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Platelet-to-lymphocyte ratio predicts tumor response and survival of patients with hepatocellular carcinoma undergoing immunotherapies Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Zi-Yi Wang, Bin Xu, Lu-Na Wang, Xiao-Dong Zhu, Cheng Huang, Ying-Hao Shen, Hui Li, Mei-Ling Li, Jian Zhou, Jia Fan, Hui-Chuan Sun
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Neuroprotective potential of pyrazole benzenesulfonamide derivative T1 in targeted intervention against PTZ-induced epilepsy-like condition in in vivo zebrafish model Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Raghul Murugan, S.P. Ramya Ranjan Nayak, B. Haridevamuthu, D. Priya, Vellapandian Chitra, Bader O. Almutairi, Selvaraj Arokiyaraj, Muthupandian Saravanan, M.K. Kathiravan, Jesu Arockiaraj
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Interleukin-1β polarization in M1 macrophage mediates myocardial fibrosis in diabetes Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Wenli Guo, Chen Yang, Jiawei Zou, Tingting Yu, Mingde Li, Ruilin He, Keyang Chen, Rafaela C.R. Hell, Eric R. Gross, Xin Zou, Yao Lu
Diabetes is a global health problem whose common complication is diabetic cardiomyopathy, characterized by chronic inflammation of the heart muscle. Macrophages are the main white blood cells found in the resting heart. Therefore, we investigated the underling mechanism of macrophage on myocardial fibrosis in diabetes. Here, echocardiography was utilized to evaluate cardiac function, and the degree
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Butyrate alleviates alcoholic liver disease-associated inflammation through macrophage regulation and polarization via the HDAC1/miR-155 axis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Lina Zhang, Zhiguo Ma, Xiaoxu Zhang, Jing Wang, Wenyan Tian, Yi Ren, Yajuan Liu, Ting Wang, Yiwei Li, Yuanyuan Liu, Wenke Shen, Ting Li, Jian Liu, Junbai Ma, Xiaoxia Zhang, Shaoqi Yang, Hao Wang
We recently found that butyrate could ameliorate inflammation of alcoholic liver disease (ALD) in mice. However, the exact mechanism remains incompletely comprehended. Here, we examined the role of butyrate on ALD-associated inflammation through macrophage (Mψ) regulation and polarization using and experiments. For experiments, C57BL/6J mice were fed modified Lieber-DeCarli liquid diets supplemented
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Fucosterol isolated from Sargassum horneri attenuates allergic responses in immunoglobulin E/bovine serum albumin-stimulated mast cells and passive cutaneous anaphylaxis in mice Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Arachchige Maheshika Kumari Jayasinghe, Hye-Won Yang, Kirinde Gedara Isuru Sandanuwan Kirindage, Kyungsook Jung, Jun-Geon Je, Lei Wang, Kil-Nam Kim, Ginnae Ahn
Allergic diseases have become a serious problem worldwide and occur when the immune system overreacts to stimuli. is an edible marine brown alga with pharmacological relevance in treating various allergy-related conditions. Therefore, this study aimed to investigate the effect of fucosterol (FST) isolated from on immunoglobulin E(IgE)/bovine serum albumin (BSA)-stimulated allergic reactions in mouse
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Examining the causal relationship between circulating immune cells and the susceptibility to osteomyelitis: A Mendelian randomization study Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Chun-Gui Liu, Dong-Yang Li, Xi Gao, Teng Ma, Kun Zhang, De-Yin Liu
Osteomyelitis is considered as a deleterious inflammatory condition affecting the bone, primarily attributed to pathogenic infection. However, the underlying factors predisposing individuals to osteomyelitis remain incompletely elucidated. The immune system plays a multifaceted role in the progression of this condition, yet previous observational studies and randomized controlled trials investigating
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HIF-1α induced by hypoxic condition regulates Treg/Th17 axis polarization in chronic immune thrombocytopenia Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-15 Hao Gu, Zhifa Wang, Xingjuan Xie, Hui Chen, Juntao Ouyang, Runhui Wu, Zhenping Chen
Immune thrombocytopenia (ITP) is an acquired immune disorder characterized by increased platelet destruction and reduced platelet (Plt) production. Hypoxia-inducible factor-1α (HIF-1α) have regulatory effects on Treg/Th17 axis balance and may represent relevant factors in the pathogenesis of ITP. Treg/Th17 ratio, serum levels and gene expression were investigated in new diagnosed ITP (NITP) and chronic
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Integration of transcriptomics and metabolomics identify biomarkers of aberrant lipid metabolism in ulcerative colitis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-14 Xuexuan Ding, Fangfang Yan, Wenjian Wang, Jingtong Qin, Lianxiang Luo
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Meta-analysis of evaluating neuron specific enolase as a serum biomarker for sepsis-associated encephalopathy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-14 Jiyun Hu, Shucai Xie, Weiping Xia, Fang Huang, Biaoxiang Xu, Zhihong Zuo, Ya Liao, Zhaoxin Qian, Lina Zhang
Brain dysfunction in sepsis is known as Sepsis-associated encephalopathy (SAE), which often results in severe cognitive and neurological sequelae and increases the risk of death. Neuron specific enolase (NSE) may serve as an important neurocritical biomarker for detection and longitudinal monitoring in SAE patients. Our Meta-analysis aimed to explore the diagnostic and prognostic value of serum NSE
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Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ377-395 peptide ameliorates neurological deficits after ischemic stroke Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-14 Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, De-Sheng Zhu, Yangtai Guan
Fibrin(ogen) deposition in the central nervous system (CNS) contributes to neuropathological injury; however, its role in ischemic stroke is unknown. In this study, we identified fibrinogen as a novel proinflammatory regulator of post-stroke neuroinflammation and revealed the neuro-protection effect of fibrin-derived γpeptide in stroke. Fibrinogen depletion and fibrinogen-derived γpeptide treatment
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The relationship and clinical significance of serum cytokine expression level and skin pruritus in patients with Hodgkin lymphoma and angioimmunoblastic T-cell lymphoma Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-14 Xin Wen, Hui Yu, Lei Zhang, Ling Li, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Xudong Zhang, Linan Zhu, Xiaolong Wu, Jiaqin Yan, Cunzhen Shi, Mengjuan Zhang, Mingzhi Zhang, Xin Li
Pruritus of lymphoma is commonly associated with both Hodgkin lymphoma (HL) and angioimmunoblastic T cell lymphoma (AITL) and critically affects the life quality of patient. Recent evidence suggests that the pruritogenic cytokines seem to play a significant role in the genesis of chronic. This study aims to investigate the cytokines associated with itching in lymphoma patients and provide the basis
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Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-14 Ruiqin Zhang, Qiuyan Jiang, Shaoyan Gao, Huizhe Zhang, Qin Xia, Bowen Liu, Jingyan Zhu, Haixia Jiang, Ruixi Zhao, Huixuan Dong, Xiaohe Li, Yanping Zhang, Cheng Yang, Xiaoting Gu, Liang Sun, Honggang Zhou
Corona Virus Disease 2019 (COVID-19) is an infectious disease that seriously endangers human life and health. The pathological anatomy results of patients who died of the COVID-19 showed that there was an excessive inflammatory response in the lungs. It is also known that most of the COVID-19 infected patients will cause different degrees of lung damage after infection, and may have pulmonary fibrosis
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CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-14 Chao Wang, Xianxu Yang
Bladder cancer (BCa) is a common malignant disease with high recurrence and poor prognosis. Several circular RNAs (circRNAs) have been found to be associated with the malignant progression of bladder cancer (BCa). Here, the aim of this study was to investigate the expression, role and mechanism of circRAPGEF5 in BCa progression. Quantitative real-time PCR (qRT-PCR) and immunoblotting were used to detect
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A prognostic model for SARS-CoV-2 breakthrough infection: Analyzing a prospective cellular immunity cohort Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-14 Mei Yang, Yuan Meng, Wudi Hao, Jin Zhang, Jianhua Liu, Lina Wu, Baoxu Lin, Yong Liu, Yue Zhang, Xiaojun Yu, Xiaoqian Wang, Yu gong, Lili Ge, Yan Fan, Conghong Xie, Yiyun Xu, Qing Chang, Yixiao Zhang, Xiaosong Qin
Following the COVID-19 pandemic, studies have identified several prevalent characteristics, especially related to lymphocyte subsets. However, limited research is available on the focus of this study, namely, the specific memory cell subsets among individuals who received COVID-19 vaccine boosters and subsequently experienced a SARS-CoV-2 breakthrough infection. Flow cytometry (FCM) was employed to
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miR-186-5p improves alveolar epithelial barrier function by targeting the wnt5a/β-catenin signaling pathway in sepsis-acute lung injury Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Mei Li, Jing Yang, Yanli Wu, Xigang Ma
Alveolar epithelial barrier dysfunction is one of the pathological features of sepsis-acute lung injury(ALI). However, the molecular mechanisms that regulate the function of alveolar epithelial barrier remain unclear. This study aimed to determine the regulatory role of miR-186-5p in alveolar epithelial barrier function in sepsis-ALI and its underlying molecular mechanism. We established sepsis-ALI
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A novel HDAC6 inhibitor attenuate APAP-induced liver injury by regulating MDH1-mediated oxidative stress Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Guo-dong Zhang, Li-li Wang, Ling Zheng, Shi-qi Wang, Rong-quan Yang, Yu-ting He, Jun-wei Wang, Ming-yu Zhao, Yi Ding, Mei Liu, Tian-yu Yang, Bao-ming Wu, Hao Cui, Lei Zhang
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Iron overload promotes hemochromatosis-associated osteoarthritis via the mTORC1-p70S6K/4E-BP1 pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Zhiyuan Fang, Chengwei Wang, Jiang Zhu, Yangyang Gou
Joint iron overload in hemochromatosis induces M1 polarization in synovial macrophages, releasing pro-inflammatory factors and leading to osteoarthritis development. However, the mechanism by which iron overload regulates M1 polarization remains unclear. This study aims to elucidate the mechanism by which synovial iron overload promotes macrophage M1 polarization. In vitro, RAW264.7 macrophages were
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IFNγ insufficiency during mouse intra-vaginal Chlamydia trachomatis infection exacerbates alternative activation in macrophages with compromised CD40 functions Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Naveen Challagundla, Dhruvi Shah, Sarat K. Dalai, Reena Agrawal-Rajput
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Olink proteomics analysis uncovers inflammatory proteins in patients with different states of bipolar disorder Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Fangming Xu, Yu Su, Xiaobo Wang, Tianle Zhang, Tingting Xie, Yumei Wang
Study Design: A prospective study. This study aims to investigate the relationship between different states of bipolar disorder (BD) and plasma inflammatory proteins, which may be used as their biomarkers. We totally collected admission plasma from 16 healthy subjects and 32 BD patients, including 16 patients with BD manic episodes (BD-M) and 16 patients with BD depressive episodes (BD-D). Ten samples
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Integrative analysis and validation of necroptosis-related molecular signature for evaluating diagnosis and immune features in Rheumatoid arthritis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Wei Wan, Xinyu Qian, Bole Zhou, Jie Gao, Jiewen Deng, Dongbao Zhao
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that is characterized by persistent morning stiffness, joint pain, and swelling. However, there is a lack of reliable diagnostic markers and therapeutic targets that are both effective and trustworthy. In this study, gene expression profiles (GSE89408, GSE55235, GSE55457, and GSE77298) were obtained from the Gene Expression Omnibus
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Maresin1 improves hippocampal neuroinflammation and cognitive function in septic rats by activating the SLC7A11 / GPX4 ferroptosis signaling pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Huiping Wu, Na Li, Shuang Peng, Haiyan Fu, Zhansheng Hu, Longxiang Su
Sepsis-associated encephalopathy (SAE) is a prevalent complication of sepsis, with hippocampal neuroinflammation playing a crucial role in SAE-induced cognitive impairment. Maresin1 (MaR1), a bioactive docosahexaenoic acid (DHA) metabolite, demonstrates comprehensive anti-inflammatory and neuroprotective attributes. Yet, its protective efficacy against SAE-induced cognitive decline remains unexplored
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Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-13 Yuxing Cai, Jiangmin Zhu, Ling Zhu, Lihong Hong, Jianfei Zhang, Lingyi Kong, Chen Chen, Jianguang Luo
Physalin H (PH), a withanolide isolated from L. has been reported to have anti-inflammatory effect. However, its impact on acute lung injury (ALI) remains unexplored. In this study, we observed that PH significantly alleviated inflammation in LPS-stimulated macrophages by suppressing the release of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and down-regulating the expression of the inflammation-related
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The role of ANXA1 in the tumor microenvironment Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Lanxin Li, Baiqi Wang, Shuang Zhao, Qinglin Xiong, Ailan Cheng
Annexin A1 (ANXA1) is widely expressed in a variety of body tissues and cells and is also involved in tumor development through multiple pathways. The invasion, metastasis, and immune escape of tumor cells depend on the interaction between tumor cells and their surrounding environment. Research shows that ANXA1 can act on a variety of cells in the tumor microenvironment (TME), and subsequently affect
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CPD-002, a novel VEGFR2 inhibitor, relieves rheumatoid arthritis by reducing angiogenesis through the suppression of the VEGFR2/PI3K/AKT signaling pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Fei Jiang, Meng-qing Wang, Man-yu Zhang, Sheng-long Gu, Ya-wen Xie, Yan Huang, Meng-yuan Zhou, Fei-long Li, Yu-chen Yang, Pei-pei Zhang, Xue-song Liu, Rong Li
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S-Adenosylmethionine (SAM) diet promotes innate immunity via histone H3K4me3 complex Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Yi Xiao, Chao Han, Xiaocong Li, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu, Fang Liu
S-adenosylmethionine (SAM) was a methyl donor for modifying histones, which had crucial roles in lipid accumulation, tissue injury, and immune responses. SAM fluctuation might be linked to variations in histone methylation. However, the underlying molecular mechanisms of whether the SAM diet influenced the immune response via histone modification remained obscure. In this study, we utilized the as
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Cancer-associated fibroblasts promote gastric cancer cell proliferation by paracrine FGF2-driven ribosome biogenesis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Dandan Li, Pan Huang, Lingyun Xia, Weidong Leng, Shanshan Qin
The cancer-associated fibroblast (CAF)-derived secretome plays critical roles in tumor progression by remodelling tumor microenvironment. Tumorigenesis is accompanied by the transformation of normal fibroblasts (NF) into CAF, leading to significant changes in their secretome. This work aims to identify the differential components of secretome between NFs and CAFs and reveal their functions in gastric
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The coumarin component isofraxidin targets the G-protein-coupled receptor S1PR1 to modulate IL-17 signaling and alleviate ulcerative colitis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Yisen Huang, Xiangbo Chen, Xiaoqiang Liu, Chanchan Lin, Yubin Wang
The increasing global prevalence of ulcerative colitis (UC) underscores the imperative to explore novel therapeutic approaches. Traditional Chinese medicine has historically shown potential in addressing this ailment. The current study aimed to elucidate the functional attributes and underlying mechanisms of isofraxidin, a coumarin derivative from Acanthopanax, in the context of UC. A murine model
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CD28null T cells in aging and diseases: From biology to assessment and intervention Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Yuqi Guan, Ming Cao, Xiaofen Wu, Jinhua Yan, Yi Hao, Cuntai Zhang
CD28 T cells, an atypical subset characterized by the loss of CD28 costimulatory molecule expression, exhibit functional variants and progressively expand with age. Moreover, T cells with these phenotypes are found in both typical and atypical humoral immune responses. Consequently, they accumulate during infectious diseases, autoimmune disorders, cardiovascular conditions, and neurodegenerative ailments
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Dapagliflozin prevents kidney podocytes pyroptosis via miR-155-5p/HO-1/NLRP3 axis modulation Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Zhen-Wang Zhang, Ming-Qiu Tang, Wu Liu, Yi Song, Man-Jun Gao, Ping Ni, Dan-Dan Zhang, Qi-gui Mo, Bao-Qing Zhao
Diabetic nephropathy (DN) is a significant clinical microvascular complication associated with diabetes mellitus (DM), and end-stage diabetes giving rise to kidney failure is developing into the major etiological factor of chronic kidney failure. Dapagliflozin is reported to limit podocyte damage in DM, which has proven to protect against renal failure. Mounting evidence has demonstrated that pyroptosis
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Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Abduallah Nasser Mansoure, Mahmoud Elshal, Manar G. Helal
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FOXA1-Driven pathways exacerbate Radiotherapy-Induced kidney injury in colorectal cancer Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-12 Minhai Zhang, Jingyuan Yang, Guodong Liang, Huiqiong Yuan, Yanni Wu, Li Li, Tao Yu, Yuling Zhang, Jingfeng Wang
This study aimed to investigate the role of FOXA1 in acute kidney injury (AKI) induced by radiotherapy in colorectal cancer. Although FOXA1 is known to be aberrantly expressed in malignant tumors, its contribution to AKI remains unclear. This study aimed to explore the involvement of FOXA1 in AKI induced by radiotherapy in colorectal cancer and its influence on the regulation of downstream target genes
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Distinct disease-modifying therapies are associated with different blood immune cell profiles in people with relapsing-remitting multiple sclerosis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-10 João Canto-Gomes, Daniela Boleixa, Catarina Teixeira, Ana Martins da Silva, Inés González-Suárez, João Cerqueira, Margarida Correia-Neves, Claudia Nobrega
Disease modifying therapies (DMTs) used for treating people with relapsing-remitting multiple sclerosis (pwRRMS) target the immune system by different mechanisms of action. However, there is a lack of a comprehensive assessment of their effects on the immune system in comparison to treatment-naïve pwRRMS. Herein, we evaluated the numbers of circulating B cells, CD4 and CD8 T cells, regulatory T cells
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A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-10 Zi-Ying Zhan, Zhi-Hong Zhang, Rong-Hui Sun, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian
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Icariin ameliorates LPS-induced acute lung injury in mice via complement C5a-C5aR1 and TLR4 signaling pathways Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-10 Jing Guo, Qi-Yun Zhang, Lin Xu, Min Li, Qian-Yun Sun
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Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-10 Yaojian Rao, Junjie Li, Ruofei Qiao, Jinxin Luo, Yan Liu
Reactive astrocytes are hallmarks of traumatic spinal cord injury (T-SCI) and are associated with neuropathic pain (NP). Mediating the functional phenotype of reactive astrocytes helps neural repair and ameliorates NP in T-SCI. Here, we aimed to explore the role of tetramethylpyrazine (TMPZ) and astragaloside IV (AGS-IV) in astrocyte polarization and the underlying molecular mechanism in T-SCI. Primary
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The activation of the AIM2 inflammasome after cigarette smoke exposure leads to an immunosuppressive lung microenvironment Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-10 Chiara Colarusso, Anna Falanga, Simone Di Caprio, Michela Terlizzi, Aldo Pinto, Piera Maiolino, Rosalinda Sorrentino
Cigarette smoke is widely known as contributing to chronic inflammation underlying several airway diseases, such as chronic obstructive pulmonary disease (COPD) and lung cancer. In our previous studies we found that the lung of both COPD and cancer patients were characterized by the presence and activation of the AIM2 inflammasome. Here, we wanted to investigate the upstream step during the establishment
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The role of BAFF and BAFF-R inhibitors in the treatment of immune thrombocytopenia; a focused review Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-10 Mohammad Ali Nilforoushzadeh, Nazila Heidari, Amirhossein Heidari, Yekta Ghane, Zahra Lotfi, Fariba Jaffary, Minou Najar Nobari, Niloufar Najar Nobari
Immune thrombocytopenia (ITP) is an autoimmune-driven disease characterized by increased destruction and impaired platelet production resulting in an enhanced risk of bleeding. Immunosuppressant agents are the most common treatment strategies for ITP. Despite their efficacy, these medications often cause unpredictable side effects. Recent investigations revealed that patients with ITP exhibit elevated
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MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-08 Tongyu Li, Siji Li
Mitochondria serve as a platform for innate immune signaling transduction, and mitochondrial antiviral signaling protein (MAVS) is essential for interferon-β (IFN-β) production and innate antiviral immunity against RNA viruses. Here, we identified zinc finger-containing ubiquitin peptidase 1 (ZUFSP/ZUP1) as a MAVS-interacting protein by using proximity-based labeling technology in HEK293T and found
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MGP+ and IDO1+ tumor-associated macrophages facilitate immunoresistance in breast cancer revealed by single-cell RNA sequencing Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-08 Kexin Chang, Yangchi Jiao, Bo Zhang, Lan Hou, Xiangmei He, Donghui Wang, Danxi Li, Ruolei Li, Zhe Wang, Pengyu Fan, Juliang Zhang
Immunotherapy is widely applied for the treatment of breast cancer, but to which some patients respond poorly or develop resistance. Therefore, the mechanism needs to be further studied. Transcriptomic data of 31 breast cancer patients treated with anti-programmed death receptor 1 (PD-1) was downloaded from the VIB-KULeuven Center for Cancer Biology to analyze the changes in myeloid cells in tumor
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Evaluation of different types of adjuvants in a malaria transmission-blocking vaccine Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-08 Xinxin Yu, Hui Min, Shijie Yao, Guixiang Yao, Di Zhang, Biying Zhang, Muyan Chen, Fei Liu, Liwang Cui, Li Zheng, Yaming Cao
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MCC950 attenuates plasma cell mastitis in an MDSC-dependent manner Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-08 Xiaowei Sun, Junchen Hou, Tianyi Ni, Zibo Xu, Wei Yan, Lianbao Kong, Qian Zhang
Plasma cell mastitis (PCM) is a sterile inflammatory condition primarily characterized by periductal inflammation and ductal ectasia. Currently, there is a lack of non-invasive or minimally invasive treatment option other than surgical intervention. The NLRP3 inflammasome has been implicated in the pathogenesis and progression of various inflammatory diseases, however, its involvement in PCM has not
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New advances in the study of PD-1/PD-L1 inhibitors-induced liver injury Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-08 Meijun Yue, Chunyu Li, Guohui Li
The application of immune checkpoint inhibitors (ICIs) has made extraordinary achievements in tumor treatment. Among them, programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors can improve the prognosis of advanced tumors, and have been widely used in clinical practice to treat many types of cancers. However, excessive immune response can also induce immune-related adverse
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Dexamethasone protects against asthma via regulating Hif-1α-glycolysis-lactate axis and protein lactylation Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-08 Ning Chen, Qiu-Meng Xie, Si-Ming Song, Si-Nuo Guo, Yu Fang, Guang-He Fei, Hui-Mei Wu
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SERPINB5 promotes colorectal cancer invasion and migration by promoting EMT and angiogenesis via the TNF-α/NF-κB pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-08 Bi-Xia Liu, Yang Xie, Jiayu Zhang, Shuyan Zeng, Jun Li, Qing Tao, Jing Yang, Youxiang Chen, Chunyan Zeng
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Identification and exploration of a new M2 macrophage marker MTLN in alveolar echinococcosis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-07 Yuyu Ma, Jiajun Li, Yumei Liu, Hui Zhao, Xinwei Qi, Yuqin Sun, Jiahui Chen, Jinping Zhou, Xiumin Ma, Liang Wang
The pathogen of alveolar echinococcosis (AE) is Echinococcus multilocularis (E. multilocularis), which has the characteristics of diffuse infiltration and growth and has a high mortality rate. At present, the role of macrophages in AE infection has attracted more and more attention, but the new biomarkers and polarization mechanisms of macrophages are rarely studied. In this study, CIBERSORT and WGCNA
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Combined transcriptomics and TMT-proteomics reveal abnormal complement and coagulation cascades in cow's milk protein allergy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-07 Qunchao Li, Yan Deng, Zhiwei Xu, Haoquan Zhou
Cow's milk protein allergy (CMPA) is primarily due to the inability of the intestinal mucosa to establish typical immunological tolerance to proteins found in cow's milk, and the specific molecular mechanism is still unclear. In order to investigate molecular alterations in intestinal tissues during CMPA occurrence, this study analyzed the jejunal tissue of β-lactoglobulin (BLG)-sensitized mice through