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Synergistic amelioration between Ligusticum striatum DC and borneol against cerebral ischemia by promoting astrocytes–mediated neurogenesis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-15 Xiaofeng Zhang, Fengjiao Deng, Xueqing Wang, Fanghan Liu, Yue Zhu, Bin Yu, Ming Ruan
Hort (LCH), with the accepted name of DC in “The Plant List” database, is a widely used ethnomedicine in treating ischemic stroke, and borneol (BO) is usually prescribed with LCH for better therapy. Our previous study confirmed their synergistic effect on neurogenesis against cerebral ischemia. However, the underlying mechanism is still unclear. More and more evidence indicated that astrocytes (ACs)
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Thai traditional medicines reduce CD147 levels in lung cells: Potential therapeutic candidates for cancers, inflammations, and COVID-19 J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-15 Kannika Sukadeetad, Bungorn Sripanidkulchai, Saowanaporn Tangsukworakhun, Ronnachai Payomchuen, Apichat Sakulchatrungroj, Sasithon Supmoon, Auradee Punkvang
The cluster of differentiation 147 (CD147) is identified as the signaling protein relevant importantly in various cancers, inflammations, and coronavirus disease 2019 (COVID-19) via interacting with extracellular cyclophilin A (CypA). The reduction of CD147 levels inhibits the progression of CD147-associated diseases. Thai traditional medicines (TTMs): Keaw-hom (), Um-ma-ruek-ka-wa-tee (), Chan-ta-lee-la
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A study on the anti-senescent effects of flavones derived from Prinsepia utilis Royle seed residue J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-15 Junxi Liu, Liping Qu, Feifei Wang, Zaoju Mei, Xinlang Wu, Bo Wang, Haiyang Liu, Li He
Prinsepia utilis Royle, also known as the Anas fruit, is a unique perennial woody oil plant from Yunnan Province, China. In the ancient texts of Dongba sutras and Yunnan Southern Materia Medica, it has been documented that the local Naxi, Tibetan, and Mosuo communities extensively utilize the root and leaf fruits of green thorns for various purposes. These include treating mild-to-moderate specific
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Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-15 Ning Xia, Jie Wang, Qiuting Guo, Jiawei Duan, Xuan Wang, Peijie Zhou, Jinkai Li, Tiantian Tang, Taotao Li, Huiting Li, Zhenfeng Wu, Ming Yang, Jing Sun, Dongyan Guo, Xing Chang, Xiaofei Zhang
is an ancient plant with significance in both medicine and perfumery that have a variety of therapeutic properties, including antidepressant, anti-anxiety, and anti-stress effects. essential oil (REO) has been used to treat depression, anxiety and other neurological related disorders in Iranian traditional medicine. However, its precise mechanism of action remains elusive. The aim of this study was
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Corrigendum to “Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3” [J. Ethnopharmacol. 270 (2021) 113765] J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-14 Ning-Ning Wang, Huan-Hua Xu, Wei Zhou, Hong-Xing Yang, Jia Wang, Zeng-Chun Ma, Yue Gao
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The molecular mechanism of action for the potent antitumor component extracted using supercritical fluid extraction from Croton crassifolius root J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-14 Xu Guo, Rui-Rui Zhang, Jin-Yue Sun, Yan Liu, Xian-Shun Yuan, Ying-Ying Chen, Hui Sun, Chao Liu
The root of has been used as a traditional Chinese medicine (TCM), called Radix Croton Crassifolius, and commonly known as “Ji Gu Xiang” in Chinese. Its medicinal value has been recorded in several medical books or handbooks, such as “Sheng Cao Yao Xing Bei Yao”, “Ben Cao Qiu Yuan” and “Zhong Hua Ben Cao”. It has been traditional employed for treating sore throat, stomach-ache, rheumatism and cancer
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Study on the therapeutic mechanism of HJ granules in a rat model of urinary tract infection caused by Escherichia coli J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-13 Shan Cao, Shuangrong Gao, Chen Ni, Yingli Xu, Bo Pang, Jingsheng Zhang, Yu Zhang, Yaxin Wang, Zihan Geng, Shurang Li, Ronghua Zhao, Bing Han, Xiaolan Cui, Yanyan Bao
Urinary tract infections (UTIs) are globally prevalent infectious diseases, predominantly caused by uropathogenic (UPEC). The misuse of antibiotics has led to the emergence of several drug-resistant strains. Traditional Chinese Medicine (TCM) has its own advantages in the treatment of UTIs. HJ granules is a herbal formula used for the treatment of UTIs. However, its mechanism of action is not clear
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Chemical composition, antioxidant, antimicrobial, and wound healing effects of Trachyspermum roxburghianum (DC.) H. Wolff essential oil: An in vivo and in silico approach J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-13 Mohan Kalaskar, Anjali Gavit, Srinivasan Prabhu, Manish Gagrani, Vinod Ugale, Saurabh Khadse, Muniappan Ayyanar, Sanjay Surana, Anilkumar Tatiya, Shailendra Gurav
(DC.) H. Wolff, commonly known as ‘Ajamoda,’ is a neglected Indian spice highly used in Ayurveda and folklore remedies as an antimicrobial for chronic wounds and discharges, along with a multitude of other disease conditions. The aim of study was to explore chemical composition and to investigate the antioxidant, antimicrobial, analgesic, and wound healing activities of fruit essential oil from India
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Extract of Silphium perfoliatum L. improve lipid accumulation in NAFLD mice by regulating AMPK/FXR signaling pathway J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-13 Jiyu Xu, Wenjing Jia, Guoying Zhang, Liying Liu, Luya Wang, Di Wu, Jihong Tao, Huilan Yue, Dejun Zhang, Xiaohui Zhao
Globally, the incidence rate and number of patients with nonalcoholic fatty liver disease are increasing, which has become one of the greatest threats to human health. However, there is still no effective therapy and medicine so far. L. is a perennial herb native to North America, which is used to improve physical fitness and treat liver and spleen related diseases in the traditional medicinal herbs
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Yinhuang buccal tablet alters airway microbiota composition and metabolite profile in healthy humans J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-13 Zhenxuan Li, Tengwen Liu, Shuo Wang, Tengfei Chen, Xuerui Wang, Xiaolong Xu, Qingquan Liu
Perturbations in airway microbiota composition and disruption of microbe-metabolite interactions have been observed in respiratory infectious diseases (RIDs). The Yinhuang (YH) buccal tablet, as an ancient Chinese medicinal formula, has been traditionally employed for the management of upper RIDs. However, there is a lack of evidence for the effects of YH buccal tablets on upper respiratory tract microbiota
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Effects of Viscum coloratum (Kom.) Nakai on collagen-induced rheumatoid arthritis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-13 Yanfu Wang, Zhichao Hao, Dongxu Lu, Anam Naseem, Ye Sun, Yan Sun, Jianzhe Li, Haixue Kuang, Yan Liu, Bingyou Yang
(Kom.) Nakai has been traditionally used in China for nearly a thousand years to treat rheumatic diseases. However, its efficacy and mechanisms in treating rheumatoid arthritis (RA) have not been demonstrated. To investigate the anti-arthritic effects and molecular mechanisms of (Kom.) Nakai on collagen-induced arthritic mice through network pharmacology technology and experimental validation. First
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Research progress on medicinal components and pharmacological activities of polygonatum sibiricum J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-13 Ruilian Liu, Xili Zhang, Yuhan Cai, Shuang Xu, Qian Xu, Chengli Ling, Xin Li, Wenjiao Li, Pingan Liu, Wenlong Liu
, commonly known as Siberian Solomon's seal, is a traditional herb widely used in various traditional medical systems, especially in East Asia. In ancient China, the use of in medicine and food was mentioned in Li Shizhen's Bencao Gangmu of traditional Chinese medicine (TCM). It was also used in history of India in Vedic medicine. The plant is rich in bioactive substances such as polysaccharides, saponins
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Sedative and hypnotic effects of the saponins from a traditional edible plant Liriope spicata Lour. in PCPA-induced insomnia mice J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-12 Yi-Meng Li, Chun-Yan Shen, Jian-Guo Jiang
Lour., a species listed in the catalogue of ‘Medicinal and Edible Homologous Species’, is traditionally used for the treatment of fatigue, restlessness, insomnia and constipation. This study is aimed to evaluate the sedative and hypnotic effect of the saponins from a natural plant Lour. . The total saponin (LSTS) and purified saponin (LSPS) were extracted from , followed by a thorough analysis of their
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Zhumian Granules improves PCPA-induced insomnia by regulating the expression level of neurotransmitters and reducing neuronal apoptosis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-12 Yuchen Bao, Hailun Zhou, Yue Fu, Chao Wang, Qinwan Huang
Sleep problems, according to Traditional Chinese medicine (TCM) philosophy, are attributed to the imbalance between yin and yang. Zhumian Granules, also known as Sleep-aid Granules or ZG, are a traditional Chinese herbal remedy specifically designed to alleviate insomnia. This formula consists of many components, including Wu Wei Zi ( Fructus), Suan Zao Ren ( Semen), and other medicinal plants. According
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Adjuvant treatment with Cordyceps sinensis for lung cancer: A systematic review and meta-analysis of randomized controlled trials J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-12 Canran Wang, Jiawei Wang, Yuanfu Qi
is a fungus parasitic on lepidopteran larvae which is often used to treat lung diseases and regulate immune function. This review aimed to evaluate the efficacy of in the adjuvant treatment of lung cancer. As of June, 2022, the electronic database search was conducted in PubMed, EMBASE, Cochrane Library, China Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang
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Epiberberine inhibits bone metastatic breast cancer-induced osteolysis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-12 Chengming Wei, Meina Shi, Zi Wang, Wenjian Lan, Na Feng, Fuming Zhang, Jiachen Liu, Jing-Yu Lang, Wanjun Lin, Wenzhe Ma
(Huanglian) is the dried rhizome from the Franch. The anti-tumor related diseases of were correlated with its traditional use of removing damp-heat, clearing internal fire, and counteracting toxicity. In the recent years, and its components have drawn extensive attention toward their anti-tumor related diseases. Besides, is traditionally used as an anti-inflammatory herb. Epiberberine (EPI) is a significant
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Homotherapy-for-heteropathy of Bupleurum Chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer: A network pharmacology and animal model approach J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-12 Ruolan Sun, Yan Liang, Shijiao Zhu, Qihang Yin, Yong Bian, Hongyue Ma, Fan Zhao, Gang Yin, Decai Tang
DC.- Georgi () is a classic drug pair that has good clinical effects on depression and many tumors. However, the concurrent targeting mechanism of how the aforementioned drug pair is valid in the two distinct diseases, has not been clarified yet. The components of were detected by LC-MS, combined with network pharmacology to explore the active ingredients and common targeting mechanism of its multi-pathway
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A comprehensive review of Pfaffia glomerata botany, ethnopharmacology, phytochemistry, biological activities, and biotechnology J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-12 Susana Tavares Cotrim Ribeiro, Naiara Cássia Gancedo, Arildo José Braz de Oliveira, Regina Aparecida Correia Gonçalves
(Spreng.) Pedersen, Amaranthaceae, is found in South America, mainly in Brazil, where it is considered a species of great medicinal interest owing to its popular use as a tonic, aphrodisiac, anti-inflammatory, and analgesic. These properties can be attributed to the presence of the phytosteroid, 20-Hydroxyecdysone (β-ecdysone), the main compound found in its roots. This review aims to provide information
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Effect and mechanism of Prunella vulgaris L. extract on alleviating lipopolysaccharide-induced acute mastitis in protecting the blood-milk barrier and reducing inflammation J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-12 Hongshan Luo, Yamei Li, Jingchen Xie, Chunfang Xu, Zhimin Zhang, Minjie Li, Bohou Xia, Zhe Shi, Limei Lin
According to ancient literature, L. () alleviates mastitis and has been used in China for many years; however, there are no relevant reports that confirm this or the mechanism of its efficacy. To explore the anti-acute mastitis effect and potential mechanism of extract. First, the active ingredients and targets of against mastitis were predicted using network pharmacology. Next, the relevant active
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Yunvjian decoction mitigates hyperglycemia in rats induced by a high-fat diet and streptozotocin via reducing oxidative stress in pancreatic beta cells J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-11 Jie Lv, Meng Su, Yansong Wang, Juan Yang, Yanni Liang, Lin Chen, Liyan Lei
Yunvjian (YNJ), a traditional Chinese herbal formula first reported in Jing Yue Quan Shu, is commonly used in the clinical treatment of type 2 diabetes mellitus (T2DM). However, the mechanism by which YNJ affects T2DM remains unclear. This study aimed to assess the therapeutic effects of YNJ on T2DM and explore the potential mechanism involved. High-performance liquid chromatography (HPLC) was used
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SiNiSan exerts antidepressant effects by modulating serotonergic/GABAergic neuron activity in the dorsal raphe nucleus region through NMDA receptor in the adolescent depression mouse model J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-11 Kerun Cao, Jialong Zhong, Shanshan Wang, Yafei Shi, Shasha Bai, Jinlan Zhao, Lei Yang, Qi Liang, Di Deng, Rong Zhang
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Inhibition of hepatocellular carcinoma cell proliferation through regulation of the cell cycle, AGE RAGE, and leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, and oroxylin a derived from Andrographis Paniculata(Burm.f.) Nees J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-11 Shiyong Gao, Huixin Tan, Jian Gang
In 2020, liver cancer contributed to approximately 0.9 million new cases and 0.83 million deaths, making it the third leading cause of mortality worldwide. (Burm.f.) Nees(APN), a traditional Chinese or ethnic medicine extensively utilized in Asia, has been historically employed for treating hepatitis and liver cancer. However, the precise molecular mechanism responsible for its therapeutic efficacy
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The arousal effect of An-Gong-Niu-Huang-Wan on alcoholic-induced coma rats: A research based on EEG J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-11 Minghong Li, Zilei Tang, Liuyan Yu, Yingming Li, Wenyu Ma, Jincun Li, Gang Li, Lei Xiong, Na Lei, Peixin Guo, Yuhuan Xie
Acute alcohol intoxication is one of the leading causes of coma. A well-regarded Chinese herbal formula, known as An-Gong-Niu-Huang-Wan (AGNHW), has garnered recognition for its efficacy in treating various brain disorders associated with impaired consciousness, including acute alcohol-induced coma. Despite its clinical effectiveness, the scientific community lacks comprehensive research on the mechanistic
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Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-11 Mengze Ding, Xiaohan Wei, Changshun Liu, Xiaomei Tan
Allergic rhinitis (AR) is a prevalent nasal inflammatory disorder, and pyroptosis plays a crucial role in aggravating AR. Current medications for AR treatment still have deficiencies, and finding new agents is of great interest. Mahuang Fuzi Xixin decoction (MFXD), an ancient Chinese medicine, is now commonly used to treat AR, which has anti-inflammatory and immunomodulatory effects, but its underlying
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A multidimensional strategy for characterization, distinction, and quality control of two Clinopodium medicinal plants J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-11 Yumeng Wang, Kaicheng Du, Quanyou Wang, Xinyong Yang, Dali Meng
Kuntze (CC) and (Vaniot) C. Y. Wu & S. J. Hsuan (CP) are both included in the Pharmacopoeia of the People's Republic of China (edition 2020) as the legitimate source of “Duan Xue Liu” (DXL), which is a crucial traditional Chinese medicine used as a clinical remedy for bleeding diseases. However, the differences in plant endogenous metabolites and bioactivities between CC and CP are still unclear. This
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Rujifang inhibits triple-negative breast cancer growth via the PI3K/AKT pathway J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-10 Wenyu Jia, Xuan Lin, Xuezhang Chen, Hongliang Li, Xingru Zhang, Yuzhuo Zhang, Yinsong Chen, Bin Wang, Xikang Chen, Ju Chen, Huaqin Tian
Rujifang (RJF) constitutes a traditional Chinese medicinal compound extensively employed in the management of triple-negative breast cancer (TNBC). However, information regarding its potential active ingredients, antitumor effects, safety, and mechanism of action remains unreported. To investigate the efficacy and safety of RJF in the context of TNBC. We employed the ultra high-performance liquid
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Comparing massa medicata fermentata before and after charred in terms of digestive promoting effect via metabolomics and microbiome analysis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-09 Siqi Fan, Huangyao Zhu, Wanqiu Liu, Jingwen Ha, Ying Liu, Ma Mi, Qingjia Ren, Lijun Xu, Jie Zhang, Wenyuan Liu, Feng Feng, Jian Xu
Massa Medicata Fermentata, a fermented Chinese medicine, is produced by the fermentation of six traditional Chinese medicines. Liu Shenqu (LSQ) and charred Liu Shenqu (CLSQ) have been used for strengthening the spleen and enhancing digestion for over a thousand years, and CLSQ is commonly used in clinical practice. However, it is unclear whether there is a difference in the spleen strengthening and
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Research status of pathogenesis of anxiety or depression after percutaneous coronary intervention and Traditional Chinese Medicine intervention J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-09 Bo Ning, Teng Ge, Qiang-Qiang Zhao, Lan-Shuan Feng, Yong-Qing Wu, Huan Chen, Kun Lian, Ming-Jun Zhao
Anxiety or depression after percutaneous coronary intervention (PCI) is a common clinical disease. Currently, conventional pharmacotherapy primarily involves the administration of anxiolytic or antidepressant medications in conjunction with anticoagulants, antiplatelet agents, and other cardiovascular drugs. However, challenges such as drug dependence, adverse reactions and related concerns persist
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Codonopsis pilosula water extract delays D-galactose-induced aging of the brain in mice by activating autophagy and regulating metabolism J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-08 Xuewen Wang, Jiachao Kang, Xuechan Li, Pingmin Wu, Yong Huang, Yongqiang Duan, Juan Feng, Jing Wang
(), also called “Dangshen” in Chinese, is derived from the roots of (Franch.) Nannf. (), var. (Nannf.) L.D.Shen ( var. ) or subsp. (Oliv.) D.Y.Hong ( subsp. ), is a well-known traditional Chinese medicine. It has been regularly used for anti-aging, strengthening the spleen and tonifying the lungs, regulating blood sugar, lowering blood pressure, strengthening the body's immune system, However, the
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Glycyrrhizae radix et rhizoma processing ameliorates adverse reactions of polygalae radix in zebra fish and rabbit models J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-07 Shi-hao Chen, Qi-wu Jiang, Su-han Yang, Bei-bei Lv, Zi-Xuan Ma, Ping Li, Wei-long Xu, Fei Li
Willd (Polygalaceae), a traditional Chinese medicine, has been used for a long time to treat various illnesses with serious adverse reactions. Glycyrrhizae radix et rhizoma processing is generally used to reduce the adverse reactions. The aim of this study was to validate the irritation caused by raw Polygalaceae (RPA), to investigate whether processed Polygalaceae (PGA) was less irritating, and to
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Red ginseng ameliorates lipotoxicity-induced renal fibrosis in hyperuricemia mice J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-07 Ying-Ling Zhang, Si-Min Chen, Yi-Jie Song, Ariful Islam, Pei-Li Rao, Meng-Jie Zhu, Wen-Yi Gu, Yu Xu, Hong-Xi Xu
Chronic kidney disease can be caused by numerous diseases including obesity and hyperuricemia (HUA). Obesity may exacerbate the renal injury caused by HUA. Red ginseng, a steamed products of Meyer root, is known for its remarkable efficacy in improving metabolic syndrome, such as maintaining lipid metabolic balance. However, the role of red ginseng on hyperuricemia-induced renal injury in obese cases
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Corrigendum to “Multi-target meridians classification based on the topological structure of anti-cancer phytochemicals using deep learning” [J. Ethnopharmacol. 319, Part 2, (30 January 2024), 117244] J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-07 Sheng Zhang, Xianwei Zhang, Jiayin Du, Wei Wang, Xitian Pi
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Identification of anti-fibrotic and pro-apoptotic bioactive compounds from Ganoderma formosanum and their possible mechanisms in modulating TGF-β1-induced lung fibrosis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-06 Kuan-Chen Cheng, Patrick Chun Theng Chong, Chen-Che Hsieh, Yu-Te Lin, Chih-Hung Ye, Darin Khumsupan, Jheng-Jhe Lu, Wei-Chieh Yu, Kai-Wen Cheng, Kah Yi Yap, Weng Si Kou, Meng-Tsung Cheng, Cheng-Chih Hsu, Lee-Yan Sheen, Shin-Ping Lin, An-Chi Wei, Shu-Han Yu
The Compendium of Materia Medica and the Classic of Materia Medica, the two most prominent records of traditional Chinese medicine, documented the therapeutic benefits of particularly in addressing pulmonary-related ailments. , an indigenous subspecies of from Taiwan, has demonstrated the same therapeutic properties. The aim of this study is to identify bioactive compounds and evaluate the potential
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Folk medicine, biological activity, and chemical profiles of Brazilian acanthaceae (Lamiales) - A review J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-06 Denise Monte Braz, Luiz Ricardo dos Santos Tozin, Kathlyn Vasconcelos Gevú, Helena Regina Pinto Lima, Viviane dos Santos, Rickson Alves Marques de Oliveira, Vítor Oliveira dos Santos, Frances Regiane dos Santos, Rosane Nora Castro, Mario Geraldo Carvalho, Raimundo Braz-Filho
The botanical family Acanthaceae (order Lamiales) potentially comprises 4900 species in 191 genera with extensive morphological, habit and habitat diversity. The family is widely distributed throughout the world but is especially rich in tropical and subtropical regions. Many of its species have great ornamental importance and are broadly used for medicinal purposes in several countries of Asia and
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Synergistic effect of paeoniflorin combined with luteolin in alleviating Lipopolysaccharides-induced acute lung injury J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-05 Zhen Liu, Junling Gao, Yuxuan Ban, Ting Ting Wan, Wenjuan Song, Wanshun Zhao, Yuou Teng
Acute lung injury (ALI) is an acute multifactorial infectious disease caused by trauma, pneumonia, shock and sepsis. Paeoniae Radix Rubra ( Pall. or Lynch, Chishao in Chinese, CS) and Salviae Miltiorrhizae Radix et Rhizoma ( Bge., Lamiaceae, Danshen in Chinese, DS) are common traditional Chinese medicines (TCMs). CS-DS herb pair has been widely used to promote blood circulation and eliminate blood
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Progress in clinical and basic research of fuzheng Huayu formula for the treatment of liver fibrosis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-05 Xiaoxi Zhou, Yadong Fu, Jiamei Chen, Ping Liu
Traditional Chinese medicine has great potential and advantages in the treatment of liver fibrosis, with Fuzheng Huayu formula (FZHY) serving as a prime example due to its remarkable efficacy in delaying and reversing liver fibrosis while simultaneously improving clinical symptoms for patients. A comprehensive literature search was conducted on FZHY, TCM319, traditional Chinese medicine 319, liver
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Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-05 Shanbo Ma, Ye Chong, Rui Zhang, Wei Quan, Jiayue Gui, Long Li, Jin Wang, Shan Miao, Xiaopeng Shi, Minggao Zhao, Kun Zhang
As a traditional Chinese medicinal herb, . Fisch. (licorice root, chinese name: Gancao) has a variety of medicinal values and is widely used clinically. Its main active ingredient, glycyrrhizic acid (GA), is believed to have a neuroprotective effect. However, the underlying biological mechanisms of GA on stress-induced anxiety disorders are still unclear. To investigate the anti-anxiety effect of GA
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Food drugs as drivers of therapeutic knowledge and the role of chemosensory qualities J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-05 Marco Leonti, Stefano Cabras, María Eugenia Castellanos Nueda, Laura Casu
Chemosensory qualities of botanical drugs are important cues for anticipating physiologic consequences. Whether a botanical drug is used as both, food and medicine, or only as medicine depends on taste preferences, nutritional content, cultural background, and the individual and overall epidemiological context. We subjected 540 botanical drugs described in having at least one oral medical application
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Corrigendum to “Fei-Yan-Qing-Hua decoction decreases hyperinflammation by inhibiting HMGB1/RAGE signaling and promotes bacterial phagocytosis in the treatment of sepsis” [J. Ethnopharmacol. (2024 Mar 1) 321:117553] J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-05 Huan Zhang, Guihua Xu, Xiao Wu, Yanwu Xu, Lirong Xu, Yingxiang Zou, Xiaodong Yang, Lingyun Pan, Biao Lei, Jingwen Mu, Qilin Huang, Yuhe Ma, Naifan Duan, Wei Zhang, Yuejuan Zheng
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Artemisia capillaris thunb. Polysaccharide alleviates cholestatic liver injury through gut microbiota modulation and Nrf2 signaling pathway activation in mice J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-04 Jingyi Cai, Zhenyun Zhu, Yuanyuan Li, Qi Li, Tian Tian, Qian Meng, Tianming Wang, Yueming Ma, Jiasheng Wu
According to traditional Chinese medicine (TCM) theory, cholestasis belongs to category of jaundice. Thunb. has been widely used for the treatment of jaundice in TCM. The polysaccharides are the one of main active components of the herb, but its effects on cholestasis remain unclear. To investigate the protective effect and mechanism of Thunb. polysaccharide (APS) on cholestasis and liver injury. The
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Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-04 Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu
Traditional Chinese medicine (TCM) has been used for centuries to treat various types of inflammation and tumors of the digestive system. L. (POL), has been used in TCM for thousands of years. The chemical composition of POL is variable and includes flavonoids, alkaloids, terpenoids and organic acids and other classes of natural compounds. Many of these compounds exhibit powerful anti-inflammatory
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Xanthoceras sorbifolium leaves alleviate hyperuricemic nephropathy by inhibiting the PI3K/AKT signaling pathway to regulate uric acid transport J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-04 Yuchao Liu, Yunqi Han, Yuquan Liu, Congying Huang, Wanze Feng, Hongwei Cui, Minhui Li
In China, Bunge was first documented as “Wen Guan Hua” in the “” in 1406 A.D. According to the , leaves are sweet and flat in nature and can dispel wind and dampness, suggesting that their extract can be used to treat rheumatoid arthritis. Bunge has also been used to treat arteriosclerosis, hyperlipidemia, hypertension, chronic hepatitis, and rheumatism, complications associated with hyperuricemic
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Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-03 Xufeng Bai, Shuwen Wang, Limei Shu, Qingyu Cao, Huiming Hu, Yanchen Zhu, Chen Chen
Hawthorn leaves are a combination of the dried leaves of the Rosaceae plants, i.e., Bge. or Bge. var. major N. E. Br., is primarily cultivated in East Asia, North America, and Europe. hawthorn leaf flavonoids (HLF) are the main part of extraction. The HLF have demonstrated potential in preventing hypertension, inflammation, hyperlipidemia, and atherosclerosis. However, the potential pharmacological
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Angelicin: A leading culprit involved in fructus Psoraleae liver injury via inhibition of VKORC1 J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-03 Tang Xuan, Jia-yin Han, Chen Pan, Chun-ying Li, Yong Zhao, Yan Yi, Yu-shi Zhang, Bao-xin Zheng, Xing-nan Yue, Ai-hua Liang
The adverse effects of Fructus Psoraleae (FP), especially liver injury, have attracted wide attention in recent years. To establish a system to explore potential hepatotoxic targets and the chief culprit of liver injury based on clinical experience, network pharmacological method, molecular docking, and and experiments. Clinical applications and adverse reactions to FP were obtained from public literatures
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Anti-inflammatory effects of the Thai herbal remedy Yataprasen and biflavonoids isolated from Putranjiva roxburghii in RAW264.7 macrophages J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-03 Supachoke Mangmool, Ratchanee Duangrat, Tulaporn Rujirayunyong, Natthinee Anantachoke
Yataprasen is a topical Thai herbal remedy for the treatment of musculoskeletal pain and is included in Kumpe Thart Phra Narai, the first Thai textbook of traditional medicine. The herbal preparation is made from a hydroethanolic extract of a mixture of 13 medicinal plants, of which Wall. leaves are the major ingredient. In this study, we investigated the underlying mechanism of action for the anti-inflammatory
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Demethylzeylasteral protects against renal interstitial fibrosis by attenuating mitochondrial complex I-mediated oxidative stress J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-02 Pan Shen, Xuan Deng, Tingting Li, Xiaoqi Chen, Xiaoyan Wu
Renal interstitial fibrosis (RIF) is a main pathological process in chronic kidney disease (CKD). Demethylzeylasteral (DML), a major component of Hook. f., has anti-renal fibrosis effects. However, its mechanism of action remains incompletely understood. The present study was designed to comprehensively examine the effects of DML on RIF and the underlying mechanisms. Pathological experiments were performed
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Integrated network pharmacology and pharmacological investigations to explore the potential mechanism of Ding-Chuan-Tang against chronic obstructive pulmonary disease J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-02 Lin-Tao Xu, Tian Wang, Qing-Tong Han, Zhen-Peng Xu, Xue-Sen Wen, Xiao-Ning Wang, Tao Shen
Ding-Chuan-Tang (Abbreviated as DCT) is frequently prescribed for treatment of respiratory diseases, including chronic obstructive pulmonary disease (COPD), which is characterized by coughing, wheezing, and chest tightness in traditional Chinese medicine (TCM). However, the potential mechanism of DCT has not been investigated. The aim of the study is to explore the efficiency of DCT in the treatment
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Corrigendum to “Tiliacora racemosa leaves induce oxidative stress mediated DNA damage leading to G2/M phase arrest and apoptosis in cervical cancer cells SiHa” [J. Ethnopharmacol. 269 (2021) 113686] J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-02 Asmita Pal, Soumee Sengupta, Rita Kundu
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Polygonati Rhizoma: A review on the extraction, purification, structural characterization, biosynthesis of the main secondary metabolites and anti-aging effects J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-02 Miao Pan, Yajing Wu, Chunyong Sun, Hang Ma, Xiaoli Ye, Xuegang Li
Polygonati Rhizome (PR) is a plant that is extensively widespread in the temperate zones of the Northern Hemisphere. It is a member of the family of Asparagaceae. PR exhibits diverse pharmacological effects and finds applications in ethnopharmacology, serving as a potent tonic for more than two millennia. PR's compounds endow it with various pharmacological properties, including anti-aging, antioxidant
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The mechanism and experimental verification of Ixeris sonchifolia promoting apoptosis of hepatocellular carcinoma based on network pharmacology: Ixeris sonchifolia Induces Hepatocellular Carcinoma Apoptosis via the PI3K/AKT Pathway J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-02 Bao-Jun Liu, Yuan-Yue Guan, Lu-Xin Qiao, Ji-Mei Zhang, Ai-Ju Li, Peng-Xiang Yang, Yu-Xue Gao, De-Xi Chen, Chun-Xiao Wang, Jin Wu
alias Kudiezi, it was named , a synonym for in the . And it was first published in J. Linn. Soc., Bot. 13: 108 (1873), which was named in the MPNS (). As a widely distributed medicinal and edible wild plant, it possesses unique bitter-cold characteristics and constituents with various pharmacological activities. Its main antitumor substances, same as artemisinin and paclitaxel, are classified as terpenoids
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ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE−/− mice to attenuate vascular inflammation and increase plaque stability J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-02 Rumin Huang, Yan Sun, Ruiyi Liu, Boran Zhu, Hailou Zhang, Haoxin Wu
Zexieyin formula (ZXYF), a traditional Chinese herbal formula recorded in the to have efficacy in relieving spleen dampness and heat accumulation syndrome, which is also the key pathogenesis of atherosclerosis (AS). The efficacy has demonstrated by our previous studies. However, the intrinsic mechanism of ZXYF for treating vascular inflammation and the effect of inflammatory response on plaque are
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Network pharmacology analysis, molecular docking integrated experimental verification reveal β-sitosterol as the active anti-NSCLC ingredient of Polygonatum cyrtonema Hua by suppression of PI3K/Akt/HIF-1α signaling pathway J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-01 Wen Cao, Fangwei Yuan, Tongyan Liu, Rong Yin
Hua (Huangjing) is a Chinese herb that is considered by ancient Chinese healers to have the effect of nourishing yin and moisturizing the lungs. It is clinically used to treat diseases of the pulmonary system, including non-small cell lung cancer. However, the precise active components and underlying mechanisms of Huangjing in the context of treating NSCLC remain uncertain. This study aimed to explore
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Effects of andiroba oil (Carapa guianensis aublet) on the immune system in inflammation and wound healing: A scoping review J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-03-01 Aimê Stefany Alves da Fonseca, Isolda de Souza Monteiro, Carolina Ramos dos Santos, Marcella Lemos Brettas Carneiro, Samuel Silva Morais, Paula Lauane Araújo, Thamis Fernandes Santana, Graziella Anselmo Joanitti
Andiroba seed oil ( Aubl.) is widely used by traditional populations in tropical countries, especially in the Brazilian Amazon, because of its anti-inflammatory, antirheumatic, antiseptic, healing and antipyretic properties, among others, which makes it useful for the treatment, mainly, of skin afflictions and wounds. To describe the modulation of the immune system by andiroba oil ( Aubl.) in inflammation
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Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-02-29 Ghazal Nabil, Yasmine H. Ahmed, Omaima Ahmed, Selvia S. Milad, Mohamed Hisham, Mohamed Rafat, Mohamed Atia, Aya A. Shokry
is widely distributed in Africa & Asia with traditional usage in alleviating abdominal colic, aches, & cramps. This plant is rich in phytochemicals, which must be explored for its pharmacological effects. Peptic lcer isease (PUD) is the digestion of the digestive tube. PUD not only interferes with food digestion & nutrient absorption, damages one of the largest defensive barriers against pathogenic
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Predicting the mechanism of action of YQYYJD prescription in the treatment of non-small cell lung cancer using transcriptomics analysis J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-02-29 Yinan Yin, Yichao Wang, Chengyan Wang, Yilu Zhang, Ao Qi, Jiajun Song, Ling Xu, Wenxiao Yang, Lijing Jiao
The efficacy of the herbal formula Yiqi Yangyin Jiedu (YQYYJD) in the treatment of advanced lung cancer has been reported in clinical trials. However, the key anti-lung cancer herbs and molecular mechanisms underlying its inhibition of lung cancer are not well-understood. To identify the key anti-lung cancer herbs in the YQYYJD formula and investigate their therapeutic effect and potential mechanism
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Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-02-29 Miao Zhao, Jun Wu, Yuchen Jin, Min Li, KeXin Yu, Haibo Yu
, the dried and ripe fruit of the magnolia family plant (Turcz.) Baill, was commonly used in traditional analgesic prescription. Studies have shown that the extract of (SC) displayed analgesic activity. However, the analgesic active component and the exact mechanisms have yet to be revealed. The present study was to investigate the anti-nociceptive constituent of , assess its analgesic effect, and
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Positive benefit-risk ratio of Psoraleae Fructus: Comprehensive safety assessment and osteogenic effects in rats J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-02-29 Zhuo Shi, Jin-chao Pan, Yi Ru, Ning-ning Shen, Yu-fu Liu, Cheng Zhang, Xiang-jun Wu, Fang-yang Li, Jia-lu Cui, Chun-qi Yang, Jun-ling Yang, Mao-xing Li, Cheng-rong Xiao, Zeng-chun Ma, Chuan Li, Yu-guang Wang, Yue Gao
Psoraleae Fructus (PF), the dried fruit of L., is a commonly used traditional medicine that has contributed to the treatment of orthopedic diseases for thousands of years in China. However, recent PF-related liver injury reports have drawn widespread attention regarding its potential hepatotoxicity risks. This study was aimed to evaluate the long-term efficacy and chronic toxicity of PF using a 26-week
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Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-02-29 Yingnan Hu, Jingyi Tang, Yongfeng Xie, Wenjun Xu, Weihan Zhu, Linying Xia, Jintao Fang, Dian Yu, Jingjing Liu, Zhipeng Zheng, Qiujing Zhou, Qiyang Shou, Wei Zhang
Chinese herbal medicine Gegen Qinlian Decoction (GQD) has been clinically shown to be an effective treatment of ulcerative colitis (UC) in China. However, the underlying mechanism of GQD's anti-ulcerative colitis properties and its effect on gut microbiota still deserve further exploration. This study observed the regulatory effects of GQD on Th2/Th1 and Tregs/Th17 cells balance, the NOD-like receptor
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Exploring the mechanism of Erteng-Sanjie capsule in treating gastric and colorectal cancers via network pharmacology and in-vivo validation J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-02-29 Wencui Zhang, Ying Wang, Han Yu, Zengcai Jin, Yuyao Yuan, Likun Liu, Jing Zhou
The Erteng-Sanjie capsule (ETSJC) has therapeutic effects against gastric cancer (GC) and colorectal cancer (CRC). However, its underlying pharmacological mechanism remains unclear. To explore the pharmacological mechanism of ETSJC against GC and CRC via network pharmacology and in-vivo validation. Data on the ingredients of ETSJC were obtained from the TCMSP and HERB databases. Further, details on
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Effective substances and molecular mechanisms guided by network pharmacology: An example study of Scrophulariae Radix treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries J. Ethnopharmacol. (IF 5.4) Pub Date : 2024-02-28 Meng-Yuan Sheng, De-Wei Peng, Hui-Ming Peng, Ya-Li Zhang, Ling Xiao, Meng-Ru Zhang, Si-Yu Wang, Chuan-Peng Zhao, Si-Ying Zhu, Jian-Kang Lu, Li Lin, Rong Huang, Jing Nie, Jin-Bo Fang
Scrophulariae Radix (Xuanshen [XS]) has been used for several years to treat hyperthyroidism. However, its effective substances and pharmacological mechanisms in the treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries have not yet been elucidated. This study aimed to explore the pharmacological material basis and potential mechanism of XS therapy for hyperthyroidism and