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Abrus precatorius Leaf Extract Stimulates Insulin-mediated Muscle Glucose Uptake: In vitro Studies and Phytochemical Analysis Planta Med. (IF 2.7) Pub Date : 2024-03-15 Chintha Lankatillake, Tien Huynh, Daniel A Dias
Diabetes mellitus, linked with insulin resistance and hyperglycaemia, is a leading cause of mortality. Glucose uptake through glucose transporter type 4, especially in skeletal muscle, is crucial for maintaining euglycaemia and is a key pathway targeted by antidiabetic medication. Abrus precatorius is a medicinal plant with demonstrated antihyperglycaemic activity in animal models, but its mechanisms
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Chemical Constituents from Agave applanata and Its Antihyperglycemic, Anti-inflammatory, and Antimicrobial Activities Associated with Its Tissue Repair Capability Planta Med. (IF 2.7) Pub Date : 2024-03-12 A. Berenice Aguilar-Guadarrama, Mónica Aideé Díaz-Román, Maribel Osorio-García, Myrna Déciga-Campos, María Yolanda Rios
Agave applanata is a Mexican agave whose fresh leaves are employed to prepare an ethanol tonic used to relieve diabetes. It is also applied to skin to relieve varicose and diabetic foot ulcers, including wounds, inflammation, and infections. In this study, the chemical composition of this ethanol tonic is established and its association with antihyperglycemic, anti-inflammatory, antimicrobial, and
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Research Progress of Natural Product Photosensitizers in Photodynamic Therapy Planta Med. (IF 2.7) Pub Date : 2024-02-29 Xiaoxia Zhou, Xufang Ying, Linjie Wu, Liqin Liu, Ying Wang, Ying He, Min Han
Photodynamic therapy is a noninvasive cancer treatment that utilizes photosensitizers to generate reactive oxygen species upon light exposure, leading to tumor cell apoptosis. Although photosensitizers have shown efficacy in clinical practice, they are associated with certain disadvantages, such as a certain degree of toxicity and limited availability. Recent studies have shown that natural product
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Unveiling Gambogenic Acid as a Promising Antitumor Compound: A Review Planta Med. (IF 2.7) Pub Date : 2024-02-29 Li Mi, Zhichao Xing, Yujie Zhang, Ting He, Anping Su, Tao Wei, Zhihui Li, Wenshuang Wu
Gambogenic acid is a derivative of gambogic acid, a polyprenylated xanthone isolated from Garcinia hanburyi. Compared with the more widely studied gambogic acid, gambogenic acid has demonstrated advantages such as a more potent antitumor effect and less systemic toxicity than gambogic acid according to early investigations. Therefore, the present review summarizes the effectiveness and mechanisms of
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Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species Planta Med. (IF 2.7) Pub Date : 2024-02-29
Ephedra species are among the most popular herbs used in traditional medicine for a long time. The ancient Chinese medical book “Treatise on Febrile Diseases” refers to the classic traditional Chinese medicine prescription Ge Gen decoction, which consists of seven herbs, including an Ephedra species. Ephedra species are utilized all over the world to treat symptoms of the common cold and coughs, and
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Development and Validation of a GC-FID Method for the Quantitation of Δ 8-Tetrahydrocannabinol and Impurities Found in Synthetic Δ 8-Tetrahydrocannabinol and Vaping Products Planta Med. (IF 2.7) Pub Date : 2024-02-22 Waseem Gul, Iram Shahzadi, Nandakumara Sarma, Nam-Cheol Kim, Mahmoud A. ElSohly
Concerns about health hazards associated with the consumption of trans-delta-8-tetrahydrocannabinol products were highlighted in public health advisories from the U. S. Food and Drug Administration and U. S. Centers for Disease Control and Prevention. Simple and rapid quantitative methods to determine trans-delta-8-tetrahydrocannabinol impurities are vital to analyze such products. In this study, a
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Affinin, Isolated from Heliopsis longipes, Induces an Antihypertensive Effect That Involves CB1 Cannabinoid Receptors and TRPA1 and TRPV1 Channel Activation Planta Med. (IF 2.7) Pub Date : 2024-02-20 Beatriz A. Luz-Martínez, Dailenys Marrero-Morfa, Francisco J. Luna-Vázquez, Alejandra Rojas-Molina, César Ibarra-Alvarado
In previous studies, we demonstrated that the ethanolic extract of Heliopsis longipes roots and its main alkamide, affinin, elicit a vasorelaxant effect through a mechanism involving activation of the gasotransmitter pathways and stimulation of cannabinoid type 1 receptors and transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 channels. However, it has not yet been
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Development of Plant-Derived Bispecific Monoclonal Antibody Targeting PD-L1 and CTLA-4 against Mouse Colorectal Cancer Planta Med. (IF 2.7) Pub Date : 2024-02-19 Christine Joy I. Bulaon, Narach Khorattanakulchai, Kaewta Rattanapisit, Hongyan Sun, Nuttapat Pisuttinusart, Waranyoo Phoolcharoen
Checkpoint blockade immunotherapy has revolutionized cancer treatment, with monoclonal antibodies targeting immune checkpoints, yielding promising clinical benefits. However, with the advent of resistance to immune checkpoint inhibitor treatment in clinical trials, developing next-generation antibodies with potentially increased efficacy is critical. Here, we aimed to generate a recombinant bispecific
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Antiproliferative and Antitelomerase Effects of Silymarin on Human Colorectal and Hepatocellular Carcinoma Cells Planta Med. (IF 2.7) Pub Date : 2024-02-08
Silymarin, a widely-used hepatoprotective agent, has shown antitumor properties in both in vitro and animal studies. Currently, there is limited knowledge regarding silymarinʼs antitelomerase effects on human colorectal cancer and hepatocyte carcinoma cells. In this study, we investigated the antiproliferative and antitelomerase effects of silymarin on four human colorectal cancer and HepG2 hepatocyte
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Memantine versus Ginkgo biloba Extract: A Comparative Study on Cognitive Dysfunction Treatment in a Novel Rat Model Planta Med. (IF 2.7) Pub Date : 2024-01-29 Essmat A. H. Allam, Abdel-Azim Assi, Dalia M. Badary, Magda M. Y. Farrag, Mariam A. Nicola
Extracellular senile plaques and intraneuronal neurofibrillary tangles are two devastating brain proteinopathies that are indicative of Alzheimerʼs disease, the most prevalent type of dementia. Currently, no effective medications are available to stop or reverse Alzheimerʼs disease. Ginkgo biloba extract, commonly referred to as EGb 761, is a natural product made from the leaves of the G. biloba tree
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Vasorelaxant effects of ellagitannins isolated from Cuphea carthagenensis Planta Med. (IF 2.7) Pub Date : 2024-01-25 Kaori Katiuska Yamaguchi Isla, Mirtes Midori Tanae, Maria Teresa Riggio de Lima-Landman, Pedro Melillo de Magalhães, Antônio José Lapa, Caden Souccar
Cuphea carthagenensis (Jacq.) J. F. Macbr. is a popular plant in Brazilian folk medicine owing to its hypotensive and central nervous system depressant effects. This study aimed to validate the hypotensive effect of the plantʼs aqueous extract (AE) in rats and examine the vascular actions of three hydrolyzable tannins, oenothein B, woodfordin C, and eucalbanin B, isolated from AE. Systolic blood pressure
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A New Blend of Litsea cubeba, Pinus mugo, and Cymbopogon winterianus Essential Oil Active as an Anti-tyrosinase Ingredient in Topical Formulations Planta Med. (IF 2.7) Pub Date : 2024-01-22 Francesca Capetti, Cecilia Cagliero, Monica Argenziano, Roberta Cavalli, Chiara Dianzani, Marta Pavarino, Carlo Bicchi, Patrizia Rubiolo, Barbara Sgorbini
Tyrosinase is a target enzyme to be inhibited in order to reduce excessive melanin production and prevent typical age-related skin disorders. Essential oils are complex mixtures of volatile compounds, belonging mainly to monoterpenoids and sesquiterpenoids, which have been relatively little studied as tyrosinase inhibitors. Among the monoterpenoids, citral (a mixture of neral and geranial) is a fragrance
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Dendropanoxide Attenuates High Glucose-induced Oxidative Damage in NRK-52E Cells via AKT/mTOR Signaling Pathway Planta Med. (IF 2.7) Pub Date : 2024-01-16 Song Hee Lee, Ju Ri Kim, Joo Kyung Shin, Jin-Sol Lee, Young Mi Kim, Jeong Hwan Kwak, Hyung Sik Kim
Hyperglycemia is a potent risk factor for the development and progression of diabetes-induced nephropathy. Dendropanoxide (DPx) is a natural compound isolated from Dendropanax morbifera (Araliaceae) that exerts various biological effects. However, the role of DPx in hyperglycemia-induced renal tubular cell injury remains unclear. The present study explored the protective mechanism of DPx on high glucose
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Toxins in Botanical Drugs and Plant-derived Food and Feed – from Science to Regulation: A Workshop Review Planta Med. (IF 2.7) Pub Date : 2024-01-10 Dieter Schrenk, Ashley Allemang, Jörg Fahrer, Henrik Harms, Xilin Li, Ge Lin, Catherine Mahony, Patrick Mulder, Ad Peijnenburg, Stefan Pfuhler, Ans Punt, Hartwig Sievers, John Troutman, Frances Widjaja
In September 2022, the 3rd International Workshop on pyrrolizidine alkaloids (PAs) and related phytotoxins was held on-line, entitled ʼToxins in botanical drugs and plant-derived food and feed – from science to regulationʼ. The workshop focused on new findings about the occurrence, exposure, toxicity, and risk assessment of PAs. In addition, new scientific results related to the risk assessment of
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Polyphenols, Antioxidants, and Wound Healing of Lecythis pisonis Seed Coats Planta Med. (IF 2.7) Pub Date : 2024-01-10
To better use the Lecythis pisonis Cambess. biomass, this study investigates whether Sapucaia seed coats present wound healing properties. We analyzed the antibacterial, antioxidant, and wound healing-promoting potentials, plus cytotoxicity and stimulation of vascular endothelial growth factor-A. The chemical composition was analyzed by positive ion mode electrospray ionization Fourier transform ion
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Zingiber zerumbet: A Scoping Review of its Medicinal Properties Planta Med. (IF 2.7) Pub Date : 2023-12-20 Janice Sue Wen Chan, Xin Yi Lim, Norfarahana Japri, Ida Farah Ahmad, Terence Yew Chin Tan
Zingiber zerumbet, a plant native to tropical and subtropical Asia, has a vast range of traditional uses and has been continuously studied for its medicinal properties. However, a systematic methodological approach in evidence synthesis on the plantʼs efficacy is lacking, and there is a need to elicit the current research status of this plant. This scoping review was conducted to systematically explore
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The Potential of Anti-coronavirus Plant Secondary Metabolites in COVID-19 Drug Discovery as an Alternative to Repurposed Drugs: A Review Planta Med. (IF 2.7) Pub Date : 2023-12-07 Zahra Alipour, Somayeh Zarezadeh, Ali Akbar Ghotbi-Ravandi
In early 2020, a global pandemic was announced due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), known to cause COVID-19. Despite worldwide efforts, there are only limited options regarding antiviral drug treatments for COVID-19. Although vaccines are now available, issues such as declining efficacy against different SARS-CoV-2 variants and the aging of vaccine-induced
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Medicinal Cannabis: Extended Stability of Cannabis Extracts Produced Using a New Ethanol-based Extraction Method Planta Med. (IF 2.7) Pub Date : 2023-11-14 Camillo Morano, Michele Dei Cas, Eleonora Casagni, Marco Pallavicini, Cristiano Bolchi, Sara Penati, Arturo Cuomo, Marco Cascella, Sabrina Bimonte, Antonia Spensiero, Andrea Ferrari, Annunziata Lombardi, Gabriella Roda
Cannabis as a therapeutic agent is increasing in popularity all around the globe, particularly in Western countries, and its potential is now well assessed. On the other hand, each country has its own regulation for the preparation of cannabis macerated oils; in Italy, there are only a few preparation methods allowed. With this work, we aim to perform a stability study of cannabis oils produced with
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Bone Fracture-healing Properties and UPLC-MS Analysis of an Enriched Flavonoid Fraction from Oxystelma esculentum Planta Med. (IF 2.7) Pub Date : 2023-11-10 Priyanka Rawat, Kriti Sharma, Sonu Khanka, Yatendra Singh, Ravi Prakash, Nisha Rais, Arvind Kumar Maurya, Ritika Gupta, Dipak K. Mishra, Divya Singh, Sanjeev Kanojiya
Oxystelma esculentum has been used as a folk medicine to treat jaundice, throat infections, and skin problems. In the current study, the bone fracture-healing properties of a flavonoid-enriched fraction (Oxy50-60F) of O. esculentum were investigated in Swiss mice using a drill-hole injury model. Oxy50-60F (1 mg/kg/day, 5 mg/kg/day, and 10 mg/kg/day) was administered orally (from the next day) after
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Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control Planta Med. (IF 2.7) Pub Date : 2023-11-07 Fábio Cassola, Nedy Ramírez, Guilherme Ribeiro, Lucas Henrique Domingos da Silva, Alessandra Gambero, Adriana da Silva Santos de Oliveira, Pedro Manoel Mendes de Moraes Vieira, Flávia Aparecida Resende Nogueira, Marta Cristina Teixeira Duarte
Seborrheic dermatitis is a chronic inflammatory disease caused by Malassezia yeast species that affects the regions of the body where the sebaceous glands are present. The combined use of different essential oils (EOs) can increase their spectrum of action. Thus, the present study aimed to evaluate the action of EOs alone and in combination with each other on M. furfur, in planktonic and biofilm form
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Investigation of the Metabolism of Astragaloside IV in a Puromycin-Damaged Rat Model by UPLC-Q-TOF-MS/MS Analysis Planta Med. (IF 2.7) Pub Date : 2023-11-06 Bing Zhang, Shiying Huang, Zhuoting Liu, Xinhui Liu, Zilan Jiang, Jianping Chen, Youjia Zeng
Astragaloside IV (AS-IV) has been shown to provide renal protection in various kidney injury models. However, the metabolic profile variation of AS-IV in pathological models in vivo is not well established. This study aims to explore the metabolic pathway of AS-IV in vivo in the classical puromycin aminonucleoside (PAN)-induced kidney injury in a rat model. Twelve Wistar rats were randomly divided
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Identification of Major Bioactive Anti-inflammatory Compounds of Derris scandens Stem Using RAW 264.7 Cells and HPLC-UV Analysis Planta Med. (IF 2.7) Pub Date : 2023-11-06 Worapol Sae-Foo, Gorawit Yusakul, Natsajee Nualkaew, Waraporn Putalun
Derris scandens (DS) is widely recognized for its therapeutic properties, specifically its analgesic effects, which significantly alleviate muscle pain. The chemical constituents of DS stem include various isoflavone derivatives. However, there is currently a lack of specified anti-inflammatory chemical markers and analytical methods for quality control. The present study aimed to evaluate the anti-inflammatory
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Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis Planta Med. (IF 2.7) Pub Date : 2023-10-30 Jun-Ho Song, Hyeon-Hwa Nam, Inkyu Park, Sungyu Yang, Jin Mi Chun, Yun-Soo Seo, Hyun-Yong Kim, Byeong Cheol Moon, Sohi Kang, Changjong Moon, Seong-IL Kang, Ji Hoon Song, Joong-Sun Kim
Agastache rugosa Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea. Thus, we aimed to reveal the morphological and micromorphological differences between A. rugosa grown on island and inland areas and their pharmacological effects on gastritis in an animal model by combining morphological
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Identification and Characterization of Chemical Constituents from Ammopiptanthus nanus Stem and Their Metabolites in Rats by UHPLC-Q-TOF-MS/MS Planta Med. (IF 2.7) Pub Date : 2023-10-30 Guanru Chen, Yanpei Sun, Dilnur Yushan, Nuerjiamali Shaerbayi, Hongjuan Zhang, Hongliang He, Yang Jin, Lina Chen
Ammopiptanthus nanus as a Kirgiz medicine is widely used for the treatment of frostbite and chronic rheumatoid arthritis. However, due to a lack of systematic research on the chemical components of A. nanus and their metabolites, the bioactive components in it remain unclear. Herein, a reliable strategy based on UHPLC-Q-TOF-MS/MS was established to comprehensively analyze the chemical components and
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New Lupanes from Alstonia scholaris Reducing Uric Acid Level Planta Med. (IF 2.7) Pub Date : 2023-10-19 Bin-Yuan Hu, Yun-Li Zhao, Yuan Xu, Xiao-Na Wang, Xiao-Dong Luo
Twelve lupanes including three new compounds named alstoscholarilups A−C (1–3) were isolated from the leaves of Alstonia scholaris. Their structures were elucidated by spectroscopic analysis and ECD calculation. Structurally, compound 1 with a rare A ring-seco skeleton formed lactone and degraded C-3, while 2 with a 28-nor and 3 with a 29-nor-lupane skeleton supported the phytochemical diversity and
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Establishment of the Daucus carota SMC-1 Cell Suspension Line for Poliovirus Vaccine Development Planta Med. (IF 2.7) Pub Date : 2023-10-18 Mónica Morales-Aguilar, Omayra Citlalli Bolaños-Martínez, Andrea Romero Maldonado, Dania O. Govea-Alonso, Christian Carreño-Campos, María Luisa Villarreal, Sergio Rosales-Mendoza, Anabel Ortiz-Caltempa
The development of virus-free, oral vaccines against poliovirus capable of inducing mucosal protective immunity is needed to safely combat this pathogen. In the present study, a carrot cell line expressing the poliovirus VP2 antigen was established at the level of callus and cell suspensions, exploring the effects of culture media (MS and B5), supplementation with urea, phytoregulators (2,4-D : KIN)
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The Potential of Berberine to Target Telocytes in Rabbit Heart Planta Med. (IF 2.7) Pub Date : 2023-10-17 Min Yang, Tong Yang, Lu Mei, Yingxing Zhang, Chunhua Liang, Xuebing Bai, Zhenwei Zhang, Yonghong Shi, Qiusheng Chen
A brand-new class of interstitial cells, called telocytes, has been detected in the heart. Telocytes can connect and transmit signals to almost all cardiomyocytes; this is highly interrelated with the occurrence and development of heart diseases. Modern studies have shown that berberine has a therapeutic effect on cardiovascular health. However, berberineʼs mechanism of action on the cardiovascular
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Sargachromenol Attenuates Inflammatory Responses by Regulating NF-κB and Nrf2 Pathways in RAW 264.7 Cells and LPS-treated Mice Planta Med. (IF 2.7) Pub Date : 2023-10-17 Eun-Ji Joung, Min-Kyeong Lee, Minsup Lee, Misung Gwon, Taisun Shin, Heeyeon Ryu, Hyeon Hak Jeong, Myeong-Jin Kim, Ji Yun Van, Jae-Il Kim, Jinkyung Choi, Won-Kyo Jung, Hyeung-Rak Kim, Bonggi Lee
This study aims to explore the anti-inflammatory mechanisms of sargachromenol in both RAW 264.7 cells and lipopolysaccharide (LPS)-treated mice, as previous reports have suggested that sargachromenol possesses anti-aging, anti-inflammatory, antioxidant, and neuroprotective properties. Although the precise mechanism behind its anti-inflammatory activity remains unclear, pretreatment with sargachromenol
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Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo Planta Med. (IF 2.7) Pub Date : 2023-10-13 Ana Gabriela Silva Oliveira, Marina Andrade Rocha, Lucas Santos de Azevedo, Aline Thaynara de Moura Coelho, Rafael César Russo Chagas, Hélio Batista Santos, Ralph Gruppi Thomé, Peter Samuel, Evelyn Wolfram, Bonglee Kim, Rui Manuel Reis, Rosy Iara Maciel Azambuja Ribeiro
Glioblastoma is the most frequent primary malignant brain tumor without effective treatment, which makes this work extremely relevant. The study of the bioactive compounds from medicinal plants plays an important role in the discovery of new drugs. This research investigated the constituents of Tapirira guianensis and its antitumor potential (in vitro and in vivo) in glioblastoma. The T. guianensis
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Consensus Statement on the Outcome of a Workshop on Paediatric Phytotherapy: Rationalising Optimal Dosing for Use in Children by Real-World Data. Planta Med. (IF 2.7) Pub Date : 2023-10-09 Andreas Hensel,Rudolf Bauer,Michael Heinrich,Karin Kraft
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Review: The Chemistry, Toxicity and Antibacterial Activity of Curcumin and Its Analogues Planta Med. (IF 2.7) Pub Date : 2023-09-28 Hannah J. Denison, Sianne L. Schwikkard, Mouhamad Khoder, Alison F. Kelly
Antimicrobial resistance is a global challenge that is already exacting a heavy price both in terms of human health and financial cost. Novel ways of approaching this crisis include the investigation of natural products. Curcumin is the major constituent in turmeric, and it is commonly used in the preparation of Asian cuisine. In addition, it possesses a wide range of pharmacological properties. This
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Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations Planta Med. (IF 2.7) Pub Date : 2023-09-25 Bernhard Retzl, Amy Marisa Zimmermann-Klemd, Moritz Winker, Sven Nicolay, Carsten Gründemann, Christian W. Gruber
Viola tricolor is a medicinal plant with documented application as an anti-inflammatory herb. The standard of care for the treatment of inflammatory bowel disease is immunosuppressive therapeutics or biologics, which often have undesired effects. We explored V. tricolor herbal preparations that are rich in an emerging class of phytochemicals with drug-like properties, so-called cyclotides. As an alternative
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Bioassay-Guided Fractionation and Biological Activity of Cardenolides from Streptocaulon juventas Planta Med. (IF 2.7) Pub Date : 2023-09-14 Yunhui Xu, Jian Xu, Wanfang Zhu, Yanling Yan, Xueyang Jiang, Zijian Xie, Feng Feng, Jie Zhang
The discovery that Na/K-ATPase acts as a signal transducer led us to investigate the structural diversity of cardiotonic steroids and study their ligand effects. By applying Na/K-ATPase activity assay-guided fractionation, we isolated a total of 20 cardiotonic steroids from Streptocaulon juventas, including an undescribed juventasoside B (10) and 19 known cardiotonic steroids. Their structures have
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Impact of Phylogenetically Diverse Bacterial Endophytes of Bergenia pacumbis on Bergenin Production in the Plant Cell Suspension Cultures Planta Med. (IF 2.7) Pub Date : 2023-09-06 Christoph Wawrosch, Martina Oberhofer, Stefan Steinbrecher, Sergey B. Zotchev
Plant in vitro cultures are potential sources for secondary metabolites. However, low productivity is often a major drawback for industrial application. Elicitation is an important strategy to improve product formation in vitro. In this context, endophytes are of special interest as biotic elicitors due to their possible interaction with the metabolism of the host plant. A total of 128 bacterial endophytes
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Immulina as an Immunostimulatory Supplement: Formulation and Pharmacological Studies Planta Med. (IF 2.7) Pub Date : 2023-08-30 Yusheng Li, Nan Ji, Minia Wang, Nirmal D. Pugh, Ikhlas A. Khan, Chalet Tan
Immulina is a commercially available extract of Arthrospira platensis enriched with bacterial lipoproteins that acts as a potent Toll-like receptor 2 agonist. However, the immunostimulatory effect of Immulina is not well understood in vivo. Here, to devise an Immulina formulation suitable for in vivo oral gavage dosing, Immulina nanosuspension was prepared and freeze-dried to yield lyophilized nano-Immulina
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Acetyl-11-Keto-Beta-Boswellic Acid Activates the Nrf2/HO-1 Signaling Pathway in Schwann Cells to Reduce Oxidative Stress and Promote Sciatic Nerve Injury Repair Planta Med. (IF 2.7) Pub Date : 2023-08-23 Chong Zhou, Yao Wang, Qiyuan Zhang, Guanghu Zhou, Xianglin Ma, Xiaowen Jiang, Wenhui Yu
Boswellia is a traditional medicine for bruises and injuries. Its main active ingredient, acetyl-11-keto-beta-boswellic acid, has antioxidant and antiapoptotic effects. In this experiment, we used Sprague-Dawley rats to make a sciatic nerve injury model to detect the transcription factor NF-E2-related factor 2/heme oxygenase 1 signaling pathway and apoptosis, combined with clinical indicators, for
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Structural Characterization and Anticomplement Activity of an Acidic Heteropolysaccharide from Lysimachia christinae Hance Planta Med. (IF 2.7) Pub Date : 2023-08-23 Zhou Hong, Li-Shuang Zhou, Zhi-Zhi Zhao, Guo-Qi Yuan, Xiao-Jiang Wang, Yan Lu, Dao-Feng Chen
A novel acidic heteropolysaccharide (LCP-90-1) was isolated and purified from a traditional “heat-clearing” Chinese medicine, Lysimachia christinae Hance. LCP-90-1 (Mw, 20.65 kDa) was composed of Man, Rha, GlcA, Glc, Gal, and Ara, with relative molar ratios of 1.00: 3.00: 11.62: 1.31: 1.64: 5.24. The backbone consisted of 1,4-α-D-GlcpA, 1,4-α-D-Glcp, 1,4-β-L-Rhap, and 1,3,5-α-L-Araf, with three branches
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Determination and Chemotaxonomic Analysis of Lanostane Triterpenoids in the Mycelia of Ganoderma spp. Using Ultra-performance Liquid Chromatography-Tandem Mass Spectrometry (I) Planta Med. (IF 2.7) Pub Date : 2023-08-14 Yawen Yue, Shuai Zhou, Chilu Cheng, Liming Teng, Jingsong Zhang, Baokai Cui, Wei Han, Yucheng Dai, Na Feng
A comprehensive and sensitive method combining ultra-performance liquid chromatography with tandem mass spectrometry was developed for the quantification of characteristic triterpenoids in Ganoderma mycelia. Eight ganoderic acids previously isolated from the mycelia of Ganoderma lingzhi were separated with a binary mobile phase on a reversed-phase C18 column. A triple quadrupole mass spectrometer equipped
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Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants Planta Med. (IF 2.7) Pub Date : 2023-07-28 Junheng Li, Yin Chen, Lei Wu, Xiaotao Tuo, Li Wang, Guanglian Zhou, Sheng-Xiong Huang, Wei Xiong, Jian-Ping Huang
Camptothecin (CPT) and its derivatives have attracted worldwide attention because of their notable anticancer activity. However, the growing demand for CPT in the global pharmaceutical industry has caused a severe shortage of CPT-producing plant resources. In this study, phytochemical analysis of Nothapodytes tomentosa results in the isolation and identification of CPT (13) and 16 analogues (1 – 12
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Vanilla pompona Leaves and Stems as New Sources of Bioactive Compounds: The Therapeutic Potential for Skin Senescence Planta Med. (IF 2.7) Pub Date : 2023-07-17 Duanyang Wang, Yhiya Amen, Marwa Elsbaey, Maki Nagata, Masako Matsumoto, Dongmei Wang, Kuniyoshi Shimizu
A large variety of natural plants are widely produced and utilised because of their remarkable pharmacological effects. In this study, two phenolic glycosides were isolated for the first time from Vanilla pompona Schiede (Orchidaceae) from Kyushu, Japan: bis [4-(β-D – O-glucopyranosyloxy)-benzyl] (S)-2-isopropylmalate (1) and bis 4-[β-D-O-glucopyranosyloxy)-benzyl]-(2R,3S)-2-isopropyl tartrate (2)
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Anthelmintic Activities of Extract and Ellagitannins from Phyllanthus urinaria against Caenorhabditis elegans and Zoonotic or Animal Parasitic Nematodes Planta Med. (IF 2.7) Pub Date : 2023-07-17 Jonathan Jato, Patrick Waindok, François Ngnodandi Belga François Ngnodandi, Emmanuel Orman, Christian Agyare, Emelia Oppong Bekoe, Christina Strube, Andreas Hensel, Eva Liebau, Verena Spiegler
The aerial parts of Phyllanthus urinaria are used in traditional medicine in West Africa against helminthiasis, but their anthelmintic potential has not been evaluated until now. Within the current study, a hydroacetonic extract (AWE) and fractions and isolated ellagitannins from P. urinaria were, therefore, tested in vitro against Caenorhabditis elegans and the larvae of the animal parasites Toxocara
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1-Methoxyerythrabyssin II Induces Autophagy in Leukemia Cells via PI3K/Akt/mTOR Pathways Planta Med. (IF 2.7) Pub Date : 2023-07-17 Bo Fang, Soeun Kim, Yebon Kim, Yinda Qiu, Chang-Min Lee, Yinshuang Lai, Zhiguo Liu, Kun Wang, Namki Cho
Leukemia, despite currently being one of the most lethal cancers worldwide, still lacks a focused treatment. The purpose of the present investigation was to evaluate the pharmacological effect of 1-methoxyerythrabyssin II, a pterocarpan identified in the roots of Lespedeza bicolor, on leukemic cells and to explore its underlying mechanism using a network pharmacology strategy. 1-Methoxyerythrabyssin
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An Update on Impacts of Epigallocatechin Gallate Co-administration in Modulating Pharmacokinetics of Statins, Calcium Channel Blockers, and Beta-blockers Planta Med. (IF 2.7) Pub Date : 2023-07-14 Lee Siew-Keah, Tan Hong Jie, Chua Ang-Lim, Liew Kai Bin, Chew Yik-Ling
Brewed green tea, green tea extract, and its primary active compound, epigallocatechin gallate, may interact with drugs and alter the drugʼs therapeutic effectiveness, ultimately leading to therapeutic failure or drug overdose. Several isolated reports have claimed that epigallocatechin gallate is the main active ingredient that causes these effects. While a few studies aimed to uncover evidence of
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In vitro Assessment of the Effects of Silybin on CYP2B6-mediated Metabolism Planta Med. (IF 2.7) Pub Date : 2023-07-14 Wenwen Zhang, Yice Zhang, Chengming Wen, Xuehua Jiang, Ling Wang
Silybin is a flavonol compound with a variety of physiological properties, such as hepatoprotective, anti-fibrogenic, and hypocholesterolemic effects. Although the in vivo and in vitro effects of silybin are frequently reported, studies on herb–drug interactions have yet to be performed. With the discovery of multiple important substrates of CYP2B6 recently, there is a growing body of evidence indicating
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Network Pharmacology and Mechanism Studies of the Protective Effect of Ginseng against Alzheimerʼs Disease Based on Aβ Pathogenesis Planta Med. (IF 2.7) Pub Date : 2023-07-14 Jinman Liu, Wenqian Yu, Cuiru Ma, Tianyao Li, Yong Liang, Shijie Su, Guangcheng Zhong, Zhouyuan Xie, Qiqing Wu, Jiaxin Chen, Qi Wang
Alzheimerʼs disease (AD) is a critical neurodegenerative disease that manifests as progressive intellectual decline and is pathologically characterized by a progressive loss of neurons in the brain. Despite extensive research on this topic, the pathogenesis of AD is not fully understood, while the beta-amyloid (Aβ) hypothesis remains the dominant one and only a few symptomatic drugs are approved for
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Impact of Dietary Nitrate on the Recovery of Therapy-related Vascular Health Impairments Following Standard Periodontal Aftercare Therapy: a Hypothesis-generating Subanalysis Planta Med. (IF 2.7) Pub Date : 2023-07-07 Yvonne Jockel-Schneider, Sophia K. Goßner, Peggy Stölzel, Imme Haubitz, Reinhold Carle, Nicole Petersen, Johannes Baulmann, Ulrich Schlagenhauf
This follow-up study assessed the impact of a nitrate-rich diet on salivary nitrate/nitrite levels and the recovery of therapy-induced vascular impairments in a cohort of 39 periodontitis patients treated by standard subgingival mechanical plaque removal (PMPR). At baseline, saliva samples for nitrate/nitrite analysis were collected, and peripheral/central blood and augmentation pressure was documented
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Bioassay-Guided Isolation and Identification of Antiplasmodial Compounds from the Stem Bark of Clausena excavata Planta Med. (IF 2.7) Pub Date : 2023-07-06 Prapairat Seephonkai, Chatthai Kaewtong, Phurpa Wangchuk, Kedchin Jearawuttanakul, Phongthon Kanjanasirirat, Suparerk Borwornpinyo, Tachin Khulmanee, Rapatbhorn Patrapuvich
Clausena excavata is a medicinal plant widely distributed in Southeast Asia. It is used for a variety of indications, including to treat malaria. In our present study, a phytochemical study of the methanol extract from the stem bark of C. excavata led to the isolation of five pyranocoumarins, nordentatin (1), dentatin (2), kinocoumarin (3), clausarin (4), and clausenidin (5), and a coumarin, 8-hydroxy-3″
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Molecular Descriptors and QSAR Models for Sedative Activity of Sesquiterpenes Administered to Mice via Inhalation Planta Med. (IF 2.7) Pub Date : 2023-07-03 Godfried Dougnon, Michiho Ito
Essential oils are often utilized for therapeutic purposes and are composed of complex structural molecules, including sesquiterpenes, with high molecular weight and potential for stereochemistry. A detailed study on the properties of selected sesquiterpenes was conducted as part of a broader investigation on the effects of sesquiterpenes on the central nervous system. A set of 18 sesquiterpenes, rigorously
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Editorial for the Special Issue Dedicated to Prof. Gerhard Franz. Planta Med. (IF 2.7) Pub Date : 2023-07-05 Susanne Alban,Robert Fürst
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Influence of Garlic on the Glycemic Control and Lipid Profile in Animals with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis Planta Med. (IF 2.7) Pub Date : 2023-06-29 Sara Shojaei-Zarghani, Nastaran Najafi, Mohammad Reza Fattahi, Ali Reza Safarpour
Nonalcoholic fatty liver disease is the hepatic sign of metabolic syndrome. Here, we aimed to assess the effects of garlic and its major components on fasting plasma glucose, fasting insulin, and lipid profile levels in animal models of nonalcoholic fatty liver disease. A systematic search in PubMed, Scopus, ProQuest, and Web of Science was performed. After the screening process and data extraction
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Polyphenols for Preventing Dental Erosion in Pre-clinical Studies with in situ Designs and Simulated Acid Attack Planta Med. (IF 2.7) Pub Date : 2023-06-29 Isabelly de Carvalho Leal, Cibele Sales Rabelo, Mary Anne Sampaio de Melo, Paulo Goberlânio de Barros Silva, Fábio Wildson Gurgel Costa, Vanara Florêncio Passos
Dental erosion is a chemical process characterized by acid dissolution of dental hard tissue, and its etiology is multifactorial. Dietary polyphenols can be a strategy for dental erosion management, collaborating to preserve dental tissues through resistance to biodegradation. This study describes a comprehensive review to interpret the effects of polyphenols on dental erosion of pre-clinical models
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Sustaining Traditional Ethnomedicinal Knowledge and Protected Areas in Synergy: A Case Study of Overa-Aru Wildlife Sanctuary in Kashmir Himalaya Planta Med. (IF 2.7) Pub Date : 2023-06-28 Tajamul Islam, Irshad A. Nawchoo, Junaid A. Magray, Anzar Ahmad Khuroo
The ethnic communities living near protected areas are critically dependent on medicinal plants for their healthcare. Although several ethnomedicinal studies are available from the Himalaya, quantitative studies focusing on protected areas in this region are largely overlooked. In this study, we aimed to document the ethnomedicinal plants of the Overa-Aru wildlife sanctuary in Kashmir Himalaya. We
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Paecilins Q and R: Antifungal Chromanones Produced by the Endophytic Fungus Pseudofusicoccum stromaticum CMRP4328 Planta Med. (IF 2.7) Pub Date : 2023-06-28 Jucélia Iantas, Daiani Cristina Savi, Larissa V. Ponomareva, Jon S. Thorson, Jürgen Rohr, Chirlei Glienke, Khaled A. Shaaban
Chemical investigation of the endophyte Pseudofusicoccum stromaticum CMRP4328 isolated from the medicinal plant Stryphnodendron adstringens yielded ten compounds, including two new dihydrochromones, paecilins Q (1) and R (2). The antifungal activity of the isolated metabolites was assessed against an important citrus pathogen, Phyllosticta citricarpa. Cytochalasin H (6) (78.3%), phomoxanthone A (3)
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Filamentous Fungi-Derived Orsellinic Acid-Sesquiterpene Meroterpenoids: Fungal Sources, Chemical Structures, Bioactivities, and Biosynthesis Planta Med. (IF 2.7) Pub Date : 2023-06-23 Hua Gao, Luning Zhou, Peng Zhang, Ying Wang, Xuan Qian, Yujia Liu, Guangwei Wu
Fungi-derived polyketide-terpenoid hybrids are important meroterpenoid natural products that possess diverse structure scaffolds with a broad spectrum of bioactivities. Herein, we focus on an ever-increasing group of meroterpenoids, orsellinic acid-sesquiterpene hybrids comprised of biosynthetic start unit orsellinic acid coupling to a farnesyl group or/and its modified cyclic products. The review
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Lyonensinols A – C, 24-Norursane-Type Triterpenoids from the Twigs and Leaves of Lyonia doyonensis and Their Potential Anti-inflammatory and PTP1B Inhibitory Activities Planta Med. (IF 2.7) Pub Date : 2023-06-21 Ming-Zhu Zhang, Meng-Yuan Jiang, Ling-Ping Kong, Cai-Ying Liu, Huai-Xin Kang, Ai-Hong Liu, Bin Wang, Shui-Chun Mao
Lyonia doyonensis is a deciduous shrub native to high-altitude regions of Asia. So far, there is no report on any chemical and biological properties of L. doyonensis. An EtOH extract of L. doyonensis twigs and leaves showed inhibitory activities on protein tyrosine phosphatase 1B and lipopolysaccharide-induced inflammation in BV-2 microglial cells. A phytochemical investigation of this extract led
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Hop-derived Humulinones Reveal Protective Effects in in vitro Models of Hepatic Steatosis, Inflammation and Fibrosis Planta Med. (IF 2.7) Pub Date : 2023-06-21 Abdo Mahli, Wolfgang E. Thasler, Martin Biendl, Claus Hellerbrand
Nonalcoholic fatty liver disease (NAFLD) is emerging as leading cause of liver disease worldwide. Specific pharmacologic therapy for NAFLD is a major unmet medical need. Recently, iso-alpha acids, hop-derived bitter compounds in beer, have been shown to beneficially affect NAFLD pathology. Humulinones are further hop derived bitter acids particularly found in modern styles of beer. So far, biological
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Anti-viral and Anti-inflammatory Isoflavonoids from Ukrainian Iris aphylla Rhizomes: Structure-Activity Relationship Coupled with ChemGPS-NP Analysis Planta Med. (IF 2.7) Pub Date : 2023-06-05 Olha Mykhailenko, Chung-Fan Hsieh, Mohamed El-Shazly, Alexander Nikishin, Vladimir Kovalyov, Pavlo Shynkarenko, Liudas Ivanauskas, Bing-Hung Chen, Jim-Tong Horng, Tsong-Long Hwang, Victoriya Georgiyants, Michal Korinek
Dried Iris rhizomes have been used in Chinese and European traditional medicine for the treatment of various diseases such as bacterial infections, cancer, and inflammation, as well as for being astringent, laxative, and diuretic agents. Eighteen phenolic compounds including some rare secondary metabolites, such as irisolidone, kikkalidone, irigenin, irisolone, germanaism B, kaempferol, and xanthone
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Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F Planta Med. (IF 2.7) Pub Date : 2023-05-26 Fernando Bombarda Oda, Flávio Alexandre Carvalho, Priscila Akemi Yamamoto, Jonata Augusto de Oliveira, Rosângela Gonçalves Peccinini, Guilherme Julião Zocolo, Paulo Riceli Vasconcelos Ribeiro, Natália Valadares de Moraes, André Gonzaga dos Santos
Oral preparations of Casearia sylvestris (guacatonga) are used as antacid, analgesic, anti-inflammatory, and antiulcerogenic medicines. The clerodane diterpenes casearin B and caseargrewiin F are major active compounds in vitro and in vivo. The oral bioavailability and metabolism of casearin B and caseargrewiin F were not previously investigated. We aimed to assess the stability of casearin B and caseargrewiin
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Potential Involvement of Organic Anion Transporters in Drug Interactions with Shuganning Injection, a Traditional Chinese Patent Medicine Planta Med. (IF 2.7) Pub Date : 2023-05-26 Yajuan Bi, Yanchao Xing, Chunshan Gui, Yiqing Tian, Mingzhe Zhang, Yao Yao, Ge Hu, Lifeng Han, Feng He, Youcai Zhang
Traditional Chinese medicine injections have been widely used in China for the treatment of various diseases. Transporter-mediated drug-drug interactions are a major contributor to adverse drug reactions. However, the research on transporter-mediated Traditional Chinese medicine injection-drug interactions is limited. Shuganning injection is a widely used Traditional Chinese medicine injection for
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Metabolic Fingerprinting of Different Sideritis Taxa Infusions and Their Neurogenic Activity Planta Med. (IF 2.7) Pub Date : 2023-05-23 Ekaterina-Michaela Tomou, Lara Bieler, Tobias Spöttl, Sebastien Couillard-Despres, Helen Skaltsa, Corinna Urmann
Over the last years, Sideritis extracts were shown to improve memory. However, their potential to promote the generation of new neurons, starting with the neuronal differentiation of neural stem cells, remains unexplored. Therefore, the present study aimed to evaluate the neurogenic effects of different Sideritis infusions in neural stem and precursor cells and their impact on cell viability. Moreover