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Optimizing organically nano-fabricated Ni metal complexes for enhanced antioxidant and anticancer activity using response surface methodology Future J. Pharm. Sci. Pub Date : 2024-03-18 Swathi Aleti, Savita Belwal, Mukunda Vani Medala
Researchers, prompted by the toxicity and side effects associated with cisplatin, are exploring alternative approaches for developing transition metal-based anticancer agents. Employing a green biochemical approach, we transformed Nickel pyridine dicarboxylic acid compounds into the nanoscale using the aqueous extract of Macrotyloma uniflorum (horse gram). Characterization of the biosynthesized nanoparticles
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Formulation and evaluation of nanobiotherapeutics of Terminalia arjuna through plant tissue culture for atherosclerosis Future J. Pharm. Sci. Pub Date : 2024-03-18 Pradnya Pradeep Wadekar, Vijay Rajaram Salunkhe
The study seeks to investigate the therapeutic potential of Terminalia arjuna callus in addressing atherosclerosis. In order to get maximum beneficial phytoconstituents from Terminalia arjuna, it is recommended to harvest the bark from Arjuna trees that are at least 15 years old and a gap of minimum 2 years should be kept before harvesting bark from the same plant. The callus culture technique was
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Chemical characterization, safety profile and antileiomyoma effects of Tetrapleura tetraptera Taubert (Fabaceae) fruit ethanol extract in Sprague Dawley rats Future J. Pharm. Sci. Pub Date : 2024-03-15 Rose Osarieme Imade, Buniyamin Adesina Ayinde, Adaeze Phina Uchendu, Silvanus Innih, Aadam Anoghena Umar, Oghenemaro Victory Agoreyo, John Marvelous Adesina
Tetrapleura tetraptera Taubert (Fabaceae) fruits are employed by herbal practitioners in the management of uterine leiomyoma, but its usage in this regard and level of safety in chronic administration has not been sufficiently established. This study evaluated the toxicity effects of T. tetraptera ethanol fruit extract and explored its antileiomyoma effect in female Sprague Dawley (SD) rats. Sub-chronic
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Solvent fractions of Vitellaria paradoxa root extract suppress phenylhydrazine-mediated jaundice in Wistar rats Future J. Pharm. Sci. Pub Date : 2024-03-14 Daniel Abu Anyebe, Abdullahi Aliyu Turaki, Abdulrahman Bashir Yusuf, Ufuoma Bigila Shemishere, Musa Idu Okwanya, Yahaya Tajudeen
In the first few days of life, jaundice has continued to be a major health concern. It typically manifests as a yellowing of the skin, mucous membranes, and sclera as a result of bilirubin deposition from excessively high concentrations in the body. It affects 80% of preterm and 60% of term new-borns within the first seven days of life, which is of great concern. According to the World Health Organization
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Characterization of biochemical and optical properties of Nile tilapia (Oreochromis niloticus) corneal collagen Future J. Pharm. Sci. Pub Date : 2024-03-13 Hatem Hassan Abd-Elrahman, Wael Abdel-Moneim Omar, Hazem Abdallah Elnashar
Collagen extracted from fish body parts is a promising biological material. It has an important role in many pharmaceutical, medical applications and tissue engineering such as corneal regeneration and stromal replacement. The present work investigates a new trend to extract collagen from the fish cornea, as a prospected substituent of human corneal collagen by characterizing some biochemical and optical
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Dual drug-loaded cubosome nanoparticles for hepatocellular carcinoma: a design of experiment approach for optimization and in vitro evaluation Future J. Pharm. Sci. Pub Date : 2024-03-11 Poorvika Badiger, V. S. Mannur, Rahul Koli
Liver cancer, a formidable and complex disease, poses a significant global health threat, stemming from various causes, including chronic infections like hepatitis B and C, cirrhosis, and lifestyle factors. In liver cancer treatment, targeted delivery revolutionizes precision therapy, minimizing side effects by directing drugs specifically to cancer cells. This study aims to develop and statistically
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Genotype–phenotype correlation of fecal Streptococcus regulator (fsr) locus with gelatinase activity and biofilm formation intensity in clinical E. faecalis isolates Future J. Pharm. Sci. Pub Date : 2024-03-08 Khaled A. Abdelrahman, Mona T. Kashef, Ramy K. Aziz, Yomna A. Hashem
Enterococci, known for their disturbing involvement in nosocomial infections, possess a diverse set of virulence factors, regulated by multiple genes. A key virulence regulator is the fecal Streptococcus regulator (Fsr) quorum sensing system. Multiple reports describe the involvement of fsr genes in several virulence mechanisms, notably gelatinase production and biofilm formation; however, the presence
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Assessing physicians’ knowledge, attitude, and practice on anticoagulant therapy in non-valvular atrial fibrillation: Syrian insights Future J. Pharm. Sci. Pub Date : 2024-03-07 Sarya Swed, Haidara Bohsas, Hidar Alibrahim, Mohamad Nour Nasif, Yasmeen Abouainain, Nagham Jawish, Angela Ishak, Bassel Dibah, Eva Mahmoud, Suzanne Mahfoud, Bisher Sawaf, Wael Hafez, Nouran Omar El Said, Engy Ahmed Wahsh
Atrial fibrillation (AF) is the most prevalent cardiac condition linked to increased mortality due to complications such as stroke. Oral anticoagulant (OAC) is the mainstay in preventing cerebrovascular accidents in patients with AF. Recent evidence identified gaps in physician’s knowledge in diagnosing and managing patients with AF. This study aims to assess Syrian physicians’ knowledge, attitude
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A comprehensive review comparing conventional versus traditional remedies in the treatment of endometriosis with futuristic insights Future J. Pharm. Sci. Pub Date : 2024-03-05 Mansi Shah, Bhavarth Dave, Shivam Bhagat, Hetansh Rao, Avinash Khadela, Nisha Parikh
A common condition known as endometriosis typically takes place in females in their reproductive age and develops generally in the endometrial lining of females. Chronically, endometriosis has been associated with a reduction in the patient’s quality of life (QOL) which can have a hazardous impact on their social working and functionality. Owing to the involvement of hormones in the development of
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Evaluating the prediction power and accuracy of two smart response surface experimental designs after revisiting repaglinide floating tablets Future J. Pharm. Sci. Pub Date : 2024-03-05 Tarek Elsayed, Rania M. Hathout
There is a soar in the figure of companies aiming to achieve efficiency in undergoing experimental processes. Therefore, instead of deploying one-factor-at-a-time, design of experiments is becoming rampantly utilized in order to reduce the resources outflow. There are a copious of different smart designs which could be employed as design of experiments tools. Central composite and d-optimal designs
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Enhanced therapeutic approach for diabetic foot ulcers: comparative study and characterisation of mupirocin-loaded nanosponge gel with marketed formulation for accelerating wound healing and in vivo evaluation Future J. Pharm. Sci. Pub Date : 2024-03-04 Rushikesh S. Dhamak, Pramod S. Salve, Deepak R. Tiwari, Pradnya A. Raut, Darshan S. Waghmare
The current investigation aimed to develop, optimise, and assess a mupirocin-loaded nanosponge-based topical delivery system for diabetic foot ulcer and to achieve prolonged drug release while improving drug deposition within the skin. The nanosponges carrying mupirocin were formulated using the emulsion solvent diffusion method. A 32 factorial design was utilised to investigate effect of two factors
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Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma Future J. Pharm. Sci. Pub Date : 2024-03-04 Ayobami Matthew Olajuyin, Onyinyechi Sharon Nwachukwu, Adefunke K. Olajuyin, Raji M. Hayatu, Adewale James, Akinrefon Adesupo, Ayodeji Mathias Adegoke, Adebola Idowu Akingbade
The overall survival of patients with lower-grade gliomas and glioblastoma varies greatly. No reliable or existing procedures can accurately forecast survival and prognostic biomarkers for early diagnosis in glioma and glioblastoma. However, investigations are progressing in immunotherapy, tumor purity, and tumor microenvironment which may be therapeutic targets for glioma and glioblastoma. This study
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Optimization of simvastatin transdermal patch for hyperlipidemia treatment in rat model Future J. Pharm. Sci. Pub Date : 2024-02-29 Neetu, Anubhav Anand, Dharamveer Panjwani
Biopharmaceutics Classification System says that simvastatin (SMV) is a Class II drug with low bioavailability (5%). This is because it dissolves slowly and is broken down a lot in the first pass. Simvastatin transdermal patches were produced as part of this study's aim to treat hyperlipidemia. The Box–Behnken design (three-factor, three-level) was selected for optimization of patches. The optimization
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Cordycepin alleviates osteoarthritis by inhibiting chondrocyte ferroptosis via Keap1/Nrf2 axis Future J. Pharm. Sci. Pub Date : 2024-02-28 Jianlei Li, Zuo Lv
Intervertebral disc degeneration (IVDD) is a prevalent condition known to contribute to lower back pain and various spinal disorders. The progression of IVDD is closely associated with cell ferroptosis. This study aimed to explore the therapeutic potential of a reactive oxygen species (ROS)-responsive hydrogel loaded with garlic extract for the inhibition of cell ferroptosis and the treatment of IVDD
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Multi-epitope-based vaccine designing against Junín virus glycoprotein: immunoinformatics approach Future J. Pharm. Sci. Pub Date : 2024-02-27 Mallari Praveen
The Junín virus (JUNV) is well known for causing argentine haemorrhagic fever (AHF), a severe endemic disease in farming premises. The glycoprotein of JUNV is an important therapeutic target in vaccine design. Despite using drugs and neutralizing weakened antibodies being used in the medication, neither the severity reduced nor eradicated the infection. However, this constraint can be resolved by immunoinformatic
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Efficacy evaluation of Berberis aristata and Silybum marianum fixed dose combination on glycaemic and insulin resistance parameters in adult population: a systematic review and meta-analysis of randomized controlled trials Future J. Pharm. Sci. Pub Date : 2024-02-27 Vishal Dubey, Jignesh Kansagra, Varun Sureja, Dharmeshkumar Kheni
Diabetes is one of the most prevalent metabolic diseases with high rate of morbidity and mortality. The increased level of blood glucose level and increased insulin resistance is the hallmark of diabetes. Currently, various non-pharmacological and pharmacological therapeutic options are used for lowering the glucose level and improving the insulin activity. The current systematic review and meta-analysis
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Antidiarrhoeal screening of Himalayan edible plant Begonia rubrovenia and its marker followed by its validation using computational analysis Future J. Pharm. Sci. Pub Date : 2024-02-27 Rupali S. Prasad, Jun M. Kalita, Nitish Rai, Nikhil Y. Yenorkar, Suhas R. Dhaswadikar, Pravesh Sharma, Mahaveer Dhobi, Damiki Laloo, Saurabh K. Sinha, Prakash R. Itankar, Satyendra K. Prasad
Diarrhoea has become one of the major areas of concern due to its high mortality rate contributing it to be the second largest cause of death in world. To explore the effectiveness of medicinal plant, the present investigation was undertaken to scientifically justify the traditional claim of the ethanolic root extract of the plant Begonia rubrovenia (EBV) against diarrhoea. EBV was standardized using
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Ethnozoological importance of Eisenia fetida and experimental validation of its anticancer activity in ascites Dalton’s lymphoma (DL) bearing mice Future J. Pharm. Sci. Pub Date : 2024-02-26 Manash Pratim Borah, Surya Bali Prasad
Eisenia fetida, commonly known as the red earthworm, holds significant ethnozoological importance due to its traditional use in various cultures as a medicinal agent. This study aims to explore the potential anticancer effects of Eisenia fetida paste (EFP) and evaluate its therapeutic efficacy in mice with ascites Dalton's lymphoma (DL). The EFP extract demonstrated a significant antitumour effect
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Biogenic metallic nanoparticles as game-changers in targeted cancer therapy: recent innovations and prospects Future J. Pharm. Sci. Pub Date : 2024-02-22 Moulika Todaria, Dipak Maity, Rajendra Awasthi
Cancer is a significant global health issue, resulting from uncontrolled cell division leading to abnormal cell or tissue growth. Traditional chemotherapeutic techniques have investigated a wide variety of pharmaceutically active molecules despite their poor bioavailability, quick renal clearance, inconsistent distribution, and unavoidable side effects. Green synthesis, unlike chemical methods, prioritizes
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Unveiling the anti-cancer potential of Euphorbia greenwayi: cytotoxicity, cell migration, and identification of its chemical constituents Future J. Pharm. Sci. Pub Date : 2024-02-21 Ahmed A. Zaghlol, Zeinab A. Kandil, Miriam F. Yousif, Riham Salah EL-Dine, Wafaa M. Elkady
Different herbal phytochemicals have potential in cancer treatment, Euphorbia genus has valuable secondary metabolites and is used in traditional medicine to treat various ailments. However, the specific constituents and biological activity of Euphorbia greenwayi remain largely unexplored. Euphorbia greenwayi aerial parts were extracted using methanol. Consequently, the methanol extract was then fractionated
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A validated, precise TLC-densitometry method for simultaneous quantification of mahanimbine and koenimbine in marketed herbal formulations Future J. Pharm. Sci. Pub Date : 2024-02-20 Nabarun Mukhopadhyay, Rezwan Ahmed, Kajal Mishra, Rujuta Sandbhor, Ram Jee Sharma, Venkata Rao Kaki
Murraya koenigii (L.) Spreng. (Rutaceae) is an important medicinal plant in natural products research for its diverse pharmacological activities. Carbazole alkaloids were the major classes of phytoconstituents obtained from different parts of this plant, such as leaves, stems, and roots. Mahanimbine and koenimbine are two important carbazole alkaloids obtained from the M. koenigii plant and are known
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Development and characterization of niosomes loaded mucoadhesive biodegradable ocular inserts for extended release of pilocarpine HCl Future J. Pharm. Sci. Pub Date : 2024-02-19 Tamara Ahmad Alotaibi, Affiong Iyire, Shereen Assaf, Eman Zmaily Dahmash
Pilocarpine HCl is a non-selective muscarinic receptor agonist that is prescribed for the treatment of glaucoma. The use of pilocarpine conventional eye drops is associated with several side effects, such as loss of visual acuity, and the need for several applications due to rapid drainage away via the nasolacrimal duct, especially for elderly people. Such adverse effects can lead to low patient compliance
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Qualitative assessment of the flowering buds of Mesua ferrea Linn with special emphasize on HPTLC and universal DNA bar-coding technique and evaluation of its antimicrobial potential Future J. Pharm. Sci. Pub Date : 2024-02-16 Jugal Sutradhar, Bapi Ray Sarkar
The study has been scientifically exploring the powder sample and extracts of flowering buds of Mesua ferrea Linn (FBMF) based on pharmacognostic and phytochemical parameters. The medicinal plant Mesua ferrea Linn was identified by Botanical verification and the universal DNA bar-coding technique. The FBMF powder’s quality was performed by the micromeritics properties like bulk density, tapped density
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Design, synthesis and in-vitro anti-depressant activity evaluation of some 2-styrylbenzimidazole derivatives Future J. Pharm. Sci. Pub Date : 2024-02-15 Manisha Sahariah, Rubina Chowdhury, Padmanath Pegu, Farak Ali, Rajat Subhra Dutta, Supriya Sahu
Existing antidepressants possess various adverse effects and so they are not considered as the first line of drug in mild depression. The lack of proper drugs to treat the mild depression on the other hand alleviates severe depressive cases. To overcome this problem, the nucleus of benzimidazole and cinnamic acid having very less toxicity were fused and a small library of 40 compounds was prepared
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Preparation and in vitro evaluation of BBG-250 loaded liposomal formulation for anticancer potential Future J. Pharm. Sci. Pub Date : 2024-02-12 Twinkle Gupta, Priyanshu Nema, Sakshi Soni, Vivek Yadav, Sanyog Jain, Vandana Soni, Sushil K. Kashaw
Liposome-mediated drug delivery systems have emerged as a promising avenue for enhancing cancer treatment strategies. This study aims to develop and assess liposomal carriers loaded with Brilliant Blue G-250 (BBG-250), a potent P2X7 receptor antagonist that shows potential as an anti-tumor agent. Specifically, two types of liposomal formulations were designed: conventional liposomes composed of hydrogenated
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Development of superior chitosan–EDTA microparticles as an adsorbent base for solidifying the self-emulsifying drug delivery systems Future J. Pharm. Sci. Pub Date : 2024-02-12 Mohit Kumar, Pooja A. Chawla, Abdul Faruk, Viney Chawla, Shubham Thakur, Subheet Kumar Jain
The present study focused on developing a superior adsorbent carrier (microparticles) to solidify the self-emulsifying drug delivery system. The two approaches, solvent evaporation and spray drying, were explored to synthesize the microparticles using chitosan (CH) and EDTA disodium. The 32 full factorial design was applied to optimize the microparticle process produced by both methods. The various
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The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients Future J. Pharm. Sci. Pub Date : 2024-02-12 Walla’a A. Osman, Heba Taher, Hanan Darweesh, Mai Abdel Samie, Olfat G. Shaker, Dina A. Labib, Hayam Ateyya
People of Mediterranean descent are primarily affected by the autoinflammatory genetic condition known as familial Mediterranean fever (FMF). The disease is resistant to colchicine therapy in 10–20% of patients. Numerous recent animal studies showed promising results of extra virgin olive oil (EVOO) to control inflammation. The objective of this study was to assess the effectiveness of combining EVOO
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Pharmaceutical significance of Schiff bases: an overview Future J. Pharm. Sci. Pub Date : 2024-02-12 Irfan Mushtaq, Maqbool Ahmad, Muhammad Saleem, Adnan Ahmed
Schiff bases are a diverse group of organic compounds with great pharmaceutical importance due to the presence of carbon–nitrogen double bonds (–C=N–). These compounds are synthesized by the condensation reaction between a primary amine and an aldehyde or ketone in a suitable solvent such as methanol. These compounds have shown antibacterial, antifungal, antiviral, anti-inflammatory, and antioxidant
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Brentuximab vedotin resistance in classic Hodgkin's lymphoma and its therapeutic strategies: a review Future J. Pharm. Sci. Pub Date : 2024-02-09 Dayeeta Bera, Dattatreya Roy
Bone marrow cancer has been at the forefront of cancer research. The propensity of cancers to extravasate to the bone makes it a very relevant topic in the topology of this heterogeneous disease. Our narrative review article addresses Brentuximab vedotin (BV) resistance in classic Hodgkin’s lymphoma patients and discusses the current trends in the therapeutic process. The data have been collected from
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Nanotechnology-based strategies overcoming the challenges of retinoblastoma: a comprehensive overview and future perspectives Future J. Pharm. Sci. Pub Date : 2024-02-09 Shymaa Hatem, Donia Mohammed, Nermeen Ezzat
Retinoblastoma (RB) is a rare type of pediatric ocular cancer with difficulty in treatment and detection owing to alterations in tumor suppressor genes and the lack of focused, efficient, and cost-effective treatments. The current review presents different approaches adopted for the treatment of RB. Recently, nanodrug delivery-based systems have shown significant reported advancements in RB treatment
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Quisqualis indica Linn.: HRLCMS/MS profiling and anti-asthma activity of leaf extracts Future J. Pharm. Sci. Pub Date : 2024-02-07 Charulata T. Nemade, Anilkumar N. Aher
Asthma is a chronic inflammatory disorder of the airways, involving various cells and cellular elements precisely eosinophils, mast cells, neutrophils, T lymphocytes, epithelial cells, and macrophages. Worldwide, about 300 million people are affected by asthma, and is expected that 100 million people may get affected, in 2025. Quisqualis indica is commonly planted as an ornamental plant in India; and
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Seaweeds as a potential resource in diabetes management: a review Future J. Pharm. Sci. Pub Date : 2024-02-07 J. S. Vidyashree, Priya P. Shetti, Shridhar C. Ghagane
Seaweeds are the marine macroalgae predominantly found in the coastal regions. These species have unique chemical profiles which makes them stand different from terrestrial plants. They are found to be rich in secondary metabolites which have potential in treating various unhealthy conditions. Diabetes is a chronic condition where an individual suffers from high or low sugar levels in the blood. This
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Comprehensive preclinical studies on the bioactivity of Orbignya phalerata Mart. (Babassu) and its derived products: a systematic review Future J. Pharm. Sci. Pub Date : 2024-01-31 Nicole Debia, Isione Oliveira Castro, Ana Beatriz Santana Sousa, Victor Alves de Oliveira, Helber Alves Negreiros, Paulo Michel Pinheiro Ferreira, João Marcelo de Castro e Sousa
Babassu (Orbignya phalerata Mart.) is a palm tree well distributed in Latin America, whose fruit has a mesocarp and kernel used for human feeding, and empirically related to the treatment of gastritis, vaginitis, and wound healing. The activities attributed to babassu can guide new research on health applications and, for this reason, this study aimed to report in vitro and in vivo biological activities
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Screening and characterization of bioactive compounds from two epiphytic microlichen and evaluation of their in vitro antioxidant activity Future J. Pharm. Sci. Pub Date : 2024-01-31 Shubham Pradhan, Satyabrata Dash, Bijayananda Sahoo, Sabyasachy Parida, Biswajit Rath
Lichens in symbiosis produce a wide range of primary and secondary fine compounds in extreme environmental conditions that have a broad range of biological properties as well as antioxidant potential and can be used in future pharmaceuticals as a natural source of antioxidant molecules. The two microlichen species collected are identified based on morphological and molecular techniques; further studies
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Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study Future J. Pharm. Sci. Pub Date : 2024-01-29 Engy A. Wahsh, Ahmed E. Abou Warda, Mahmoud S. Abdallah, Aya Elsayed, Yasser Soliman Abdel Daiem, Eman Mohamed Sadek
Pharmacists have an important role in preventing prescribing errors and providing appropriate information. They can detect potential drug–drug interactions (DDIs), which are associated with a more extended hospital stay and higher medical costs that lead to substantial financial burdens on healthcare systems. This study aimed to evaluate and assess the knowledge of community and hospital pharmacists
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A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study Future J. Pharm. Sci. Pub Date : 2024-01-19 Haitham A. El Fiky, Maha F. Abd El Ghany, Amr M. Badawey, N. V. Fares, Dina A. Ahmed
Carivalan® dosage form containing carvedilol and ivabradine is widely indicated for patients with stable angina. Three precise, eco-friendly and reproducible spectrophotometric techniques were created for resolving the researched drugs in their mixtures using zero and/or ratio spectra. Technique I is a factorized dual wavelength coupled with spectrum subtraction (FDW-SS), technique II is a ratio difference
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In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma Future J. Pharm. Sci. Pub Date : 2024-01-12 Marvin Antonio Soriano-Ursúa, Angélica Vega-García, Vinnitsa Buzoianu-Anguiano, Ana Lilia Ocampo-Nestor, Joaquín Manjarrez-Marmolejo, Iris Angélica Feria-Romero
Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tumour have a poor prognosis because after surgical treatment, radiotherapy and/or chemotherapy, these tumours eventually regrow or progress. To date, there is no effective treatment that can cure affected patients. Quercetin and 3-bromopyruvate are chemical compounds that have been
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Antioxidant and acetylcholinesterase inhibitory activities, in silico analyses, and anti-Alzheimer’s disease potential of leaf extracts of three Nigerian endemic medicinal plants (Spondias mombin, Carica papaya and Kalanchoe crenata) Future J. Pharm. Sci. Pub Date : 2024-01-08 Aanuoluwapo Ruth Adetuyi, Michael E. Ayenero, Mary T. Olaleye, Afolabi A. Akindahunsi, Afolabi C. Akinmoladun
The evaluation of the correlations between antioxidant and anti-acetylcholinesterase activities of methanol leaf extracts of three Nigerian endemic plants, Spondias mombin, Carica papaya and Kalanchoe crenata, was carried out. Their constituent phytochemicals were identified by HPLC–DAD fingerprinting. The antioxidant activity as typified by 2,2-diphenyl-1-picrylhydrazyl (DPPH·), 2,2′-azino-bis-(3
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Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management Future J. Pharm. Sci. Pub Date : 2024-01-05 Dipak D. Gadade, Hariom Jha, Chetan Kumar, Farzan Khan
Personalized or Precision medicine (PM) is a promising approach for the cancer treatment that tailors treatment to a patient's characteristics. Biomarkers are crucial for identifying the patients who are expected to derive greatest advantage from targeted therapy. Here, various biomarkers, including genetic, epigenetic, protein, and metabolites, and their clinical significance, are discussed. The review
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Nanocrystals: an emerging paradigm for cancer therapeutics Future J. Pharm. Sci. Pub Date : 2024-01-05 Ayush Patel, Krishi Patel, Viral Patel, Mithun Singh Rajput, Ravish Patel, Amarjitsing Rajput
Medical fraternity are continuously pitching toward the development of novel mechanisms to combat the menace of cancer and to enhance the efficacy of prevailing molecules. During the drug development phase, majority of new molecular entity pose a threat due to hydrophobic nature, that compromises its bioavailability upon administration. These suboptimal accumulation and low drug loading hampers the
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Integrating in silico molecular docking, ADMET analysis of C.verticillata with diabetic markers and in vitro anti-inflammatory activity Future J. Pharm. Sci. Pub Date : 2024-01-05 Maheswari A., Salamun DE
Over the past decade, various research studies have proved the interconnection between the inflammatory pathways and diabetes complication in clinical condition. The present study evaluated the anti-inflammatory and antioxidant activity. Further, the sample was tested for its pharmacokinetics properties and the best compounds were docked with the diabetic markers (DPP IV (PDB-ID: IJ2E) and SGLT2 (PDB-ID:
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Multifaceted applications of micro/nanorobots in pharmaceutical drug delivery systems: a comprehensive review Future J. Pharm. Sci. Pub Date : 2024-01-03 Tanisha Das, Shirin Sultana
Drug delivery systems (DDSs) encompass a wide range of methods, including oral, injectable, and topical routes of administration, all tailored to meet specific patient needs. Micro and nanorobots, equipped with pioneering propulsion mechanisms that convert external energy sources into precise movements, have revolutionized drug delivery. This cutting-edge technology ensures highly efficient drug delivery
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Bioanalytical method development and validation for the simultaneous estimation of Olanzapine and Samidorphan in rabbit plasma by using HPLC–MS/MS and application to pharmacokinetic study Future J. Pharm. Sci. Pub Date : 2024-01-02 Rambabu Kantipudi, Sugandha Kumar Pavuluri
Samidorphan is an opioid antagonist while Olanzapine is an effective medication for schizophrenia and bipolar disorder. A unique and accurate MS/HPLC approach due to simultaneous measurement of Olanzapine and Samidorphan is, therefore, more urgently required. Simultaneous quantification of Olanzapine and Samidorphan in rabbit plasma using HPLC-MS. Using a buffer composed of 1 mL of formic acid in 1 L
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Nano-calcium incorporated piscean collagen scaffolds: potential wound dressing material Future J. Pharm. Sci. Pub Date : 2023-12-21 Chaitra Shree TJ, Sindhu Abraham, Sharon Furtado, Darshan Ramesh, Kesha Desai, Bharath Srinivasan
Collagen proteins extracted from piscean sources are alternatives to bovine and porcine collagen because of their abundance, low price, and skin compatibility and are being explored as suitable wound dressing materials. Intracellular calcium ions are crucial for wound healing, and studies have shown that calcium ion supplementation via an external medium is equally beneficial for speedy recovery. This
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Nanoemulsion drug delivery system loaded with imiquimod: a QbD-based strategy for augmenting anti-cancer effects Future J. Pharm. Sci. Pub Date : 2023-12-20 Shital Tanaji Jadhav, Vijay Rajaram Salunkhe, Somnath Devidas Bhinge
Skin cancer is becoming a public health concern due to increased exposure to environmental pollutants and UV rays, among other factors. In India, skin neoplasms constitute 2–3% of all human cancer cases, whereas in the USA, 2–3 million cases of non-melanoma skin cancer are reported annually. Various drugs are available in the market for treating skin cancer. Imiquimod (IMQ) is one such drug approved
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Isolation and characterization of undescribed flavonoid from Abrus precatorius L. based on HPTLC-DPPH bioautography and its cytotoxicity evaluation Future J. Pharm. Sci. Pub Date : 2023-12-19 Hafsa I. Ansari, Ranjitsinh C. Dabhi, Pooja G. Trivedi, Milan S. Thakar, Jayesh J. Maru, Gaurang M. Sindhav
Naturally derived compounds play a tremendous role as a drug as well as lead structure for the development of APIs. Therefore, isolation and characterization of compounds from nature are needed to alleviate life-threatening diseases. A. precatorius L. belongs to the family Leguminosae and is valued for its medicinal properties. Therefore, in this study, efforts are being made to isolate bioactive entity
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Interaction of telmisartan and related sartans with the programmed cell death-ligand 1 (PD-L1) protein dimer: a molecular docking analysis Future J. Pharm. Sci. Pub Date : 2023-12-18 Gérard Vergoten, Christian Bailly
Telmisartan (TLT) is a prototypic angiotensin receptor blocker largely used to treat hypertension worldwide. In addition to its cardioprotective effects, TLT presents pleiotropic activities and notably displays noticeable anti-inflammatory and antitumor effects. The repression of the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint may be implicated antitumor action
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Optimization and evaluation of microwave-assisted curcumin-loaded nanostructured lipid carriers: a green approach Future J. Pharm. Sci. Pub Date : 2023-12-15 Sunidhi Lohan, Ravinder Verma, Deepak Kaushik, Meenakshi Bhatia
The goal of current research work is to develop and optimize curcumin-encapsulated nanostructured lipid carriers and to enhance therapeutic effect of curcumin after oral administration. Curcumin-loaded nanostructured lipid carriers were developed by a single-step one-pot microwave-assisted technique. The preparation of curcumin-loaded nanostructured lipid carriers was optimized by employing two factors
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Chlorogenic acid-optimized nanophytovesicles: a novel approach for enhanced permeability and oral bioavailability Future J. Pharm. Sci. Pub Date : 2023-12-13 Hemangi R. Trivedi, Prashant K. Puranik
Chlorogenic acid, a phenolic derivative, shows excellent pharmacological properties. However, poor lipidic solubility, permeability, and oral bioavailability restrict its clinical use. Therefore, two different phospholipids—Phospholipon® 90H and LIPOID® S100 nanophytovesicles (NPVs)—were optimized, formulated and compared with central composite design for improved biopharmaceutical properties, antioxidant
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GC–MS and ADME profile analysis of Carcinoscorpius rotundicauda bioactive compounds and their potential as COVID-19 antiviral Future J. Pharm. Sci. Pub Date : 2023-12-11 Ahmad Misbakhus Sururi, Dwi Anggorowati Rahayu, Martina Kurnia Rohma, Maftukhatul Faizah, Elsa Aulia Vebianawati, Mia Savita
Carcinoscorpius rotundicauda is a species of horseshoe crab that is rarely studied. This animal is often used as part of the blood as a medical sterilization material. This study aims to identify the content of bioactive compounds and their bioactivity as an antiviral for COVID-19. The stages of this research include extraction, GC–MS analysis, molecular docking analysis, and ADME analysis. The results
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Phytochemical profiling, antioxidant and antimicrobial investigations on Viburnum simonsii Hook. f. & Thoms, an unexplored ethnomedicinal plant of Meghalaya, India Future J. Pharm. Sci. Pub Date : 2023-12-11 Samson Rosly Sangma, Mayur Mausoom Phukan, Vahshi Chongloi, Dakeshwar Kumar Verma, Plaban Bora, Sony Kumari, Pranay Punj Pankaj
Viburnum simonsii Hook. f. & Thoms is one of the 17 Viburnum species reported from India. Viburnum species such as Viburnum opulus and Viburnum grandiflorum have been used since time immemorial to treat various ailments and their therapeutic claims have been scientifically validated. However, the species under investigation despite having a long traditional usage history for the treatment of various
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Pharmacokinetics of nanoparticles: current knowledge, future directions and its implications in drug delivery Future J. Pharm. Sci. Pub Date : 2023-12-11 Muthukrishnan Haripriyaa, Krishnamurthy Suthindhiran
Nanoparticles have emerged as a viable biological candidate with the possibility to be employed as drug carriers. They acquire high surface-to-volume ratios and unique physicochemical features such as biochemical, magnetic, optical, and electrical changes at the cellular, atomic, and molecular levels. This phenomenon has proven extensive utility for biomedical applications, as their biological activity
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Chemical profiling of antifungal Dicerocaryum senecioides and Diospyros mespiliformis extracts using TLC-p-iodonitrotetrazolium violet assay and GC–MS/MS Future J. Pharm. Sci. Pub Date : 2023-12-04 R. Zhou, P. Dzomba, L. Gwatidzo
Despite the availability of conventional medication for fungal skin diseases, dermatophytic infections are now a major crisis in the whole world due to multidrug resistance. In an effort to search for complementary and alternative remedies, this study evaluated the chemical composition of Dicerocaryum senecioides and Diospyros mespiliformis leaf and fruit extracts, respectively, exhibiting significant
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Inhibitory capacity of extracts and main constituents of hop flowers Future J. Pharm. Sci. Pub Date : 2023-12-01 Francisco Mateus Gomes do Nascimento, Samuel Pedro Dantas Marques, Maria Teresa Salles Trevisan, Robert Wyn Owen, Lucas Ramos Pereira, Thales Caldas Lima, Anderson Freitas de Sousa, Carlos Eduardo Gonçalves Maia
Hops (Humulus lupulus Linn.) produce flowers that are used on an industrial scale to impart sensory properties to beer and have some pharmacologic properties already published in the literature. Gout, type 2 diabetes and Alzheimer’s are diseases the appearance/aggravation of which is related to the action of enzymes such as xanthine oxidase, α-glucosidase and acetylcholinesterase, respectively, which
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QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers Future J. Pharm. Sci. Pub Date : 2023-11-29 Ankaj Kumar, Sandeep Jat, Pramod Kumar, Arvind Gulbake
In cancer therapies, chemo-herbal combinations are receiving increased attention. A multiple tyrosine kinase inhibitor, lenvatinib (LTB) is beneficial in treating thyroid, lung, endometrial, and liver cancers. An isoflavone called biochanin A (BCA) is well known for its diverse biological properties that have been studied to potentiate the anti-cancer potential and lower the normal cell toxicities
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Peptide-modified PAMAM-based bone-targeting RNA delivery system Future J. Pharm. Sci. Pub Date : 2023-11-21 Suryaji Patil, Yong-Guang Gao, Airong Qian
Osteoporosis, among other bone diseases, has become a prevalent cause of decreased quality of life in older and postmenopausal women. Traditional anti-osteoporotic therapies, though widely prescribed, are limited by a lack of cell- or tissue-specific targeting ability and effectiveness without side effects. Gene therapy is rapidly replacing traditional therapeutics, primarily because of its specific
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A validated RP-UPLC method for estimation of Samidorphan and Olanzapine in mixed powder and combined tablets Future J. Pharm. Sci. Pub Date : 2023-11-21 Krishnaphanisri Ponnekanti, Ramreddy Godela
The key objective of the research study is to develop a new stability-indicating RP-UPLC approach to determine the presence of Samidorphan and Olanzapine simultaneously in bulk and their combination. A successful separation of Samidorphan and Olanzapine was achieved by using HSS column C18 (100 × 2.1 mm), a mobile phase of 0.1% orthophospharic acid: Acetonitrile (70:30 v/v), flow rate of 0.3 mL/min
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Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS Future J. Pharm. Sci. Pub Date : 2023-11-20 Bhawani Sunkara, Ganesh Kumar Tummalapalli Naga Venkata
In the dapagliflozin (DPF) synthesis, 5-Bromo-2-chlorobenzoic acid (5-BC impurity) and 4-Bromo-1-chloro-2-(4-ethoxybenzyl) benzene (4-BC impurity) are used as starting and reagent sources, respectively. The presence of 5-BC and 4-BC impurities in DPF could potentially affect the effectiveness of the final DPF product. The purpose of this investigation was to develop a stability indicating HPLC methodology
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A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration Future J. Pharm. Sci. Pub Date : 2023-11-16 Harshwardhan G. Gunjal, Vivek V. Byahatti
Since long, triamcinolone and fluocinolone, fluorinated derivatives, have been used for treating various types of dermatitis. Rosacea and perioral dermatitis are the most common side effects observed with prolonged use of fluorinated derivatives. Recent studies have shown that these adverse effects are more severe at low doses of fluorinated derivatives compared to low doses of non-fluorinated derivatives
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IVIVC assessment, pharmacokinetic evaluation, and X-ray radiography mapping of Novel Parteck® SRP 80 and hypromellose-loaded LTD4 receptor antagonist chronosystem Future J. Pharm. Sci. Pub Date : 2023-11-13 Saniya Jawed, C. S. Satish
The current research aims to determine the pharmacokinetic parameters, mucoadhesive strength, and IVIVC correlation of the novel chronotherapeutic drug delivery system of montelukast sodium (MTS) loaded Parteck® SRP80 and hypromellose system. To accomplish this, an HPLC method was developed which is highly sensitive, precise, and rapid for quantifying pure MTS in rabbit plasma. Mucoadhesive strength