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Evidence of brain metabolism redistribution from neocortex to primitive brain structures in early acute COVID-19 respiratory syndrome EJNMMI Res. (IF 3.2) Pub Date : 2024-03-12 Stephan P. M. Souza, Nicoli Colet, Mariana Fujiwara, Alins P. Fernandes, Natalia Tobar, Sergio S. J. Dertkigil, Maria Emilia S. Takahashi, Bárbara J. Amorim, Lucas S. Silva, Clarissa L. Yasuda, Fernando Cendes, Thiago F. de Souza, Juliano T. Rodrigues, Denise E. Zantut-Wittmann, Celso Dario Ramos
Neuropsychiatric sequelae of COVID-19 have been widely documented in patients with severe neurological symptoms during the chronic or subacute phase of the disease. However, it remains unclear whether subclinical changes in brain metabolism can occur early in the acute phase of the disease. The aim of this study was to identify and quantify changes in brain metabolism in patients hospitalized for acute
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Improving multi-pinhole CZT myocardial perfusion imaging specificity without changing sensibility by using adapted filter parameters EJNMMI Res. (IF 3.2) Pub Date : 2024-03-07 Fabien Vauchot, Julien Dubois, Aurélie Bourdon
Meta-analysis show the diagnostic performance of cardiac dedicated multi-pinhole cadmium-zinc-telluride myocardial perfusion imaging (MPI) with a sensibility around 0.9 and a specificity around 0.7. The aim of the present study is to explore a simple method to generate less artefact on MPI using single photon emission computed tomography (SPECT) and to enhance specificity without changing sensibility
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Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids EJNMMI Res. (IF 3.2) Pub Date : 2024-03-07 Catarina I. G. Pinto, André D. M. Branco, Sara Bucar, Alexandra Fonseca, Antero J. Abrunhosa, Cláudia L. da Silva, Joana F. Guerreiro, Filipa Mendes
Glioblastoma is an extremely aggressive malignant tumor with a very poor prognosis. Due to the increased proliferation rate of glioblastoma, there is the development of hypoxic regions, characterized by an increased concentration of copper (Cu). Considering this, 64Cu has attracted attention as a possible theranostic radionuclide for glioblastoma. In particular, [64Cu]CuCl2 accumulates in glioblastoma
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Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA EJNMMI Res. (IF 3.2) Pub Date : 2024-03-06 Obada M. Alzghool, Richard Aarnio, Jatta S. Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J. Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O. Rinne, Merja Haaparanta-Solin
P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [11C]SMW139 is the most recently developed radiotracer to image P2X7 receptor. The aim of this study was to image reactive glia in the APP/PS1-21 transgenic (TG) mouse model of Aβ deposition longitudinally using [11C]SMW139 targeting P2X7 receptor and to compare tracer uptake
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Dynamic whole-body [18F]FES PET/CT increases lesion visibility in patients with metastatic breast cancer EJNMMI Res. (IF 3.2) Pub Date : 2024-03-04 Mette A. Pedersen, Ole L. Munk, André H. Dias, Johanne H. Steffensen, Anders L. Møller, Anna Lyhne Johnsson, Kim Vang Hansen, Dirk Bender, Steen Jakobsen, Morten Busk, Lars C. Gormsen, Trine Tramm, Signe Borgquist, Mikkel H. Vendelbo
Correct classification of estrogen receptor (ER) status is essential for prognosis and treatment planning in patients with breast cancer (BC). Therefore, it is recommended to sample tumor tissue from an accessible metastasis. However, ER expression can show intra- and intertumoral heterogeneity. 16α-[18F]fluoroestradiol ([18F]FES) Positron Emission Tomography/Computed Tomography (PET/CT) allows noninvasive
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Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs EJNMMI Res. (IF 3.2) Pub Date : 2024-03-02 Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester, Thomas Günther
We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in the tumor. However, one major drawback of these first generation rh-based cholecystokinin-2 receptor (CCK-2R) ligands is their elevated activity levels in the kidneys, especially at later time
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Pharmacodynamics and biodistribution of [195mPt]cisplatin(CISSPECT®) in head and neck squamous cell carcinoma EJNMMI Res. (IF 3.2) Pub Date : 2024-03-01 Reinout H. de Roest, Marijke Stigter van Walsum, Karlijn van der Schilden, Ruud H. Brakenhoff
Cisplatin- based chemoradiotherapy is a crucial pillar in the treatment of HNSCC. The use of cisplatin comes with high toxicity rates as 35% of patients cannot sustain the planned dose while response is unpredictable. Unfortunately, there are no clinically applicable biomarkers to predict response. Based on the association of response with the number of DNA adducts and the involved molecular pathway
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The efficacy of short acquisition time using 18F-FDG total-body PET/CT for the identification of pediatric epileptic foci EJNMMI Res. (IF 3.2) Pub Date : 2024-02-26 Min Li, Xiao Cui, Huixin Yue, Chao Ma, Kun Li, Leiying Chai, Min Ge, Hui Li, Yee Ling Ng, Yun Zhou, Jianguo Shi, Yanhua Duan, Zhaoping Cheng
18F-FDG positron emission tomography (PET) plays a crucial part in the evaluation for pediatric epileptic patients prior to therapy. Short-term scanning holds significant importance, especially for pediatrics epileptic individuals who exhibited involuntary movements. The aim was to evaluate the effects of short acquisition time on image quality and lesion detectability in pediatric epileptic patients
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Evaluation of therapeutic effect and prognostic value of 18F-FDG PET/CT in different treatment nodes of DLBCL patients EJNMMI Res. (IF 3.2) Pub Date : 2024-02-19 Wenyu Zhao, Xiaodong Wu, Shuo Huang, Hui Wang, Hongliang Fu
In the present study, we aimed to investigate the role of baseline (B), interim (I) and end-of-treatment (Eot) 18F-FDG PET/CT in assessing the prognosis of diffuse large B cell lymphoma (DLBCL), so as to identify patients who need intensive treatment at an early stage. A total of 127 DLBCL patients (62 men; 65 women; median age 62 years) were retrospectively analyzed in this study. Baseline (n = 127)
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Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor EJNMMI Res. (IF 3.2) Pub Date : 2024-02-16 Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, Albert D. Windhorst
Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the receptor's function. However, subsequent treatment resistance mutations in the ATP binding site are common. The EGFR allosteric inhibitor, EAI045, is proposed to have an alternative
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Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET EJNMMI Res. (IF 3.2) Pub Date : 2024-02-15 Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman
Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be present, which influences quantification. The aim was to investigate the presence of non-specific irreversible uptake in tumour tissue using Patlak linearization
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Relaxed fibronectin: a potential novel target for imaging endometriotic lesions EJNMMI Res. (IF 3.2) Pub Date : 2024-02-10 Belinda Trachsel, Stefan Imobersteg, Giulia Valpreda, Gad Singer, Regula Grabherr, Mark Ormos, Irene A. Burger, Rahel A. Kubik-Huch, Roger Schibli, Viola Vogel, Martin Béhé
Endometriosis is characterized by the ectopic occurrence of endometrial tissue. Though considered benign, endometriotic lesions possess tumor-like properties such as tissue invasion and remodeling of the extracellular matrix. One major clinical hurdle concerning endometriosis is its diagnosis. The diagnostic modalities ultrasound and MRI are often unable to detect all lesions, and a clear correlation
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Spherization indices measured by resting SPECT improve risk stratification in patients with ischemia with non-obstructive coronary artery disease (INOCA) EJNMMI Res. (IF 3.2) Pub Date : 2024-02-07 Yuting Zhao, Yingqi Hu, Yuanyuan Li, Yanhui Wang, Yuxin Xiao, Li Xu, Tailin Ren, Qiuyan Wu, Ruonan Wang, Zhifang Wu, Sijin Li, Ping Wu
The prevalence of ischemia with non-obstructive coronary artery disease (INOCA) is substantial, but its risk stratification has been suboptimal. Resting SPECT myocardial perfusion imaging (MPI) could provide useful heart information including spherical indices. We aimed to evaluate the prognostic value of spherical indices in individuals with INOCA. During a median follow-up of 47.2 ± 20.8 months,
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Exploring the impact of PEGylation on pharmacokinetics: a size-dependent effect of polyethylene glycol on prostate-specific membrane antigen inhibitors EJNMMI Res. (IF 3.2) Pub Date : 2024-02-07 Yang Liu, Li Xia, Haiyang Li, Ping Cai, Sufan Tang, Yue Feng, Guangfu Liu, Yue Chen, Nan Liu, Wei Zhang, Zhijun Zhou
Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer-related deaths in men. Prostate-specific membrane antigen (PSMA) as a target has gained increasing attention. This research aims to investigate and understand how altering size of PEG impacts the in vitro and in vivo behavior and performance of PSMA inhibitors, with a specific focus on their pharmacokinetic characteristics
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The image quality and feasibility of solitary delayed [68 Ga]Ga-PSMA-11 PET/CT using long field-of-view scanning in patients with prostate cancer EJNMMI Res. (IF 3.2) Pub Date : 2024-02-06 Xiaofeng Yu, Lian Xu, Gang Huang, Jianjun Liu, Ruohua Chen, Yumei Chen
Previous studies have demonstrated that delayed [68 Ga]Ga-PSMA PET/CT imaging improves lesion detection compared to early [68 Ga]Ga-PSMA PET/CT in patients with prostate cancer. However, the sole use of delayed [68 Ga]Ga-PSMA PET/CT has been limited due to the insufficient number of photons obtained with standard PET/CT scanners. The combination of early and delayed [68 Ga]Ga-PSMA standard PET/CT may
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Risk of treatment-altering haematological toxicity and its dependence on bone marrow doses in peptide receptor radionuclide therapy EJNMMI Res. (IF 3.2) Pub Date : 2024-02-06 Märta Persson, Cecilia Hindorf, Oscar Ardenfors, Martin Larsson, Joachim N. Nilsson
Peptide receptor radionuclide therapy is effective in treating neuroendocrine tumours, but treatment may be limited by kidney and bone marrow toxicity. In this work, the absorbed dose burden to the bone marrow was estimated using image-based dosimetry and its potential use for predicting treatment-altering toxicity was studied. Peripheral blood samples taken before and after 229 treatments with 177Lu-DOTATATE
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A histogram of [18F]BBPA PET imaging differentiates non-neoplastic lesions from malignant brain tumors EJNMMI Res. (IF 3.2) Pub Date : 2024-02-02 Ziren Kong, Zhu Li, Junyi Chen, Yixin Shi, Nan Li, Wenbin Ma, Yu Wang, Zhi Yang, Zhibo Liu
Differentiating treatment response from tumor progression is fundamental but challenging for almost all oncological subjects, as the treatment strategy is effective and should be insisted in the former situation, while the therapeutic regimen is invalid and necessitates substitutions in the latter circumstances [1]. However, radiotherapy or immunotherapy may induce pseudo-progression, a transient increase
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Repeatability of [15O]H2O PET imaging for lower extremity skeletal muscle perfusion: a test–retest study EJNMMI Res. (IF 3.2) Pub Date : 2024-01-31 Nana Louise Christensen, Jens Sørensen, Kirsten Bouchelouche, Michael Alle Madsen, Christian Selmer Buhl, Lars Poulsen Tolbod
[15O]H2O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis and treatment of peripheral artery disease. We aimed to evaluate the reliability of dynamic [15O]H2O PET imaging for measuring lower extremity skeletal muscle perfusion. Ten healthy participants underwent same-day test–retest study with six dynamic [15O]H2O PET scans of lower
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ParaPET: non-invasive deep learning method for direct parametric brain PET reconstruction using histoimages EJNMMI Res. (IF 3.2) Pub Date : 2024-01-30 Rajat Vashistha, Hamed Moradi, Amanda Hammond, Kieran O’Brien, Axel Rominger, Hasan Sari, Kuangyu Shi, Viktor Vegh, David Reutens
The indirect method for generating parametric images in positron emission tomography (PET) involves the acquisition and reconstruction of dynamic images and temporal modelling of tissue activity given a measured arterial input function. This approach is not robust, as noise in each dynamic image leads to a degradation in parameter estimation. Direct methods incorporate into the image reconstruction
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Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer’s disease and amnestic mild cognitive impairment using integrated PET/MR EJNMMI Res. (IF 3.2) Pub Date : 2024-01-25 Sheng Bi, Shaozhen Yan, Zhigeng Chen, Bixiao Cui, Yi Shan, Hongwei Yang, Zhigang Qi, Zhilian Zhao, Ying Han, Jie Lu
Developing biomarkers for early stage AD patients is crucial. Glucose metabolism measured by 18F-FDG PET is the most common biomarker for evaluating cellular energy metabolism to diagnose AD. Arterial spin labeling (ASL) MRI can potentially provide comparable diagnostic information to 18F-FDG PET in patients with neurodegenerative disorders. However, the conclusions about the diagnostic performance
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18F-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation EJNMMI Res. (IF 3.2) Pub Date : 2024-01-22 Yong-il Kim, Seung Hak Lee, Jin Hwa Jung, Seog-Young Kim, Nare Ko, Sang Ju Lee, Seung Jun Oh, Jin-Sook Ryu, Dabin Ko, Won Kim, Kyunggon Kim
The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury. Hence, we investigated the utility of the 18F-ASEM alpha7-nAChR targeting radiotracer as a new diagnostic method by visualizing skeletal muscle denervation in mouse models of sciatic nerve injury. Ten-week-old
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Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490 EJNMMI Res. (IF 3.2) Pub Date : 2024-01-11 Victoria J. M. Reid, Wesley K. X. McLoughlin, Kalyani Pandya, Holly Stott, Monika Iškauskienė, Algirdas Šačkus, Judit A. Marti, Dominic Kurian, Thomas M. Wishart, Christophe Lucatelli, Dan Peters, Gillian A. Gray, Andrew H. Baker, David E. Newby, Patrick W. F. Hadoke, Adriana A. S. Tavares, Mark G. MacAskill
Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targeting these processes could be used to elucidate cardiac wound healing mechanisms. The alpha7 nicotinic acetylcholine receptor (ɑ7nAChR) stimulates pro-reparative macrophage activity and angiogenesis
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Comparison of tracer kinetic models for 68Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients EJNMMI Res. (IF 3.2) Pub Date : 2024-01-10 Nathaniel J. Smith, Mark A. Green, Clinton D. Bahler, Mark Tann, Wendy Territo, Anne M. Smith, Gary D. Hutchins
68Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified as standard uptake values (SUVs) for clinical decision-making. However, analysis of dynamic images characterizing both tracer uptake and pharmacokinetics may offer added insights into the underlying
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ImmunoPET provides a novel way to visualize the CD103+ tissue-resident memory T cell to predict the response of immune checkpoint inhibitors EJNMMI Res. (IF 3.2) Pub Date : 2024-01-05 Xiaoyu Fan, Hans W. Nijman, Marco de Bruyn, Philip H. Elsinga
Immune checkpoint inhibitors (ICIs) have made significant progress in oncotherapy improving survival of patients. However, the benefits are limited to only a small subgroup of patients who could achieve durable responses. Early prediction of response may enable treatment optimization and patient stratification. Therefore, developing appropriate biomarkers is critical to monitoring efficacy and assessing
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Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoacetyltriglycine SPECT in mice EJNMMI Res. (IF 3.2) Pub Date : 2024-01-05 Fabian Schmitz-Peiffer, Mathias Lukas, Ajay-Mohan Mohan, Jakob Albrecht, Jörg R. Aschenbach, Winfried Brenner, Nicola Beindorff
The influence of anaesthetic depth and the potential influence of different anaesthetic beds and thus different handling procedures were investigated in 86 severe combined immunodeficient (SCID) mice using semi-stationary dynamic single photon emission computed tomography (SPECT) for kidney scintigraphy. Therefore, isoflurane concentrations were adjusted using respiratory rate for low (80–90 breath/min)
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PSMA imaging as a non-invasive tool to monitor inducible gene expression in vivo EJNMMI Res. (IF 3.2) Pub Date : 2024-01-04 Marin Simunic, Jay T. Joshi, Helen Merkens, Nadine Colpo, Hsiou-Ting Kuo, Julian J. Lum, François Bénard
Tetracycline (Tet)-On and Tet-Off systems have been widely used in biomedical research as an important tool allowing for controlled gene expression in eukaryotic cells and organisms [1,2,3,4]. Those systems become effective upon binding of a tetracycline class antibiotic [5], either by switching off gene expression in a so-called Tet-Off system or by inducing gene expression in a Tet-On system, wherein
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[68 Ga]Ga-FAPI-04 PET/CT may be a predictor for early treatment response in rheumatoid arthritis EJNMMI Res. (IF 3.2) Pub Date : 2024-01-04 Qingqing Pan, Huaxia Yang, Ziyue Zhou, Min Li, Xu Jiang, Fang Li, Yaping Luo, Mengtao Li
The identification of biomarkers predicting the treatment response of rheumatoid arthritis (RA) is important. [68 Ga]Ga-FAPI-04 showed markedly increased uptake in the joints of patients with RA. The purpose of this study is to investigate whether [68 Ga]Ga-FAPI-04 PET/CT can be a predictor of treatment response in RA. Nineteen patients diagnosed with RA in the prospective cohort study were finally
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A short 18F-FDG imaging window triple injection neuroimaging protocol for parametric mapping in PET EJNMMI Res. (IF 3.2) Pub Date : 2024-01-02 Hamed Moradi, Rajat Vashistha, Kieran O’Brien, Amanda Hammond, Viktor Vegh, David Reutens
In parametric PET, kinetic parameters are extracted from dynamic PET images. It is not commonly used in clinical practice because of long scan times and the requirement for an arterial input function (AIF). To address these limitations, we designed an 18F-fluorodeoxyglucose (18F-FDG) triple injection dynamic PET protocol for brain imaging with a standard field of view PET scanner using a 24-min imaging
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Advancements in theranostic applications: exploring the role of fibroblast activation protein inhibition tracers in enhancing thyroid health assessment EJNMMI Res. (IF 3.2) Pub Date : 2023-12-22 Yuhua Wang, Ye Liu, Huixia Geng, Wanchun Zhang
The diagnostic accuracy of [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography imaging in accurately identifying thyroid lesions is limited, primarily due to the physiological uptake of normal head and neck tissues and inflammatory uptake in lymph nodes. Since fibroblast activating protein is highly expressed in tumors and largely unexpressed in normal tissues, quinoline-based fibroblast
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[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma EJNMMI Res. (IF 3.2) Pub Date : 2023-12-18 Peter Iversen, Stine Kramer, Andreas Ebbehoj, Esben Søndergaard, Kirstine Stochholm, Per Løgstrup Poulsen, Karin Hjorthaug
Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only available in small series. We conducted a retrospective comparative analysis of FDOPA and DOTATOC to assess their sensitivity and accuracy in detecting PPGL when administered based on suspicion
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Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells EJNMMI Res. (IF 3.2) Pub Date : 2023-12-15 Pierre Cheung, Julia Thorngren, Bo Zhang, Svitlana Vasylovska, Francesco Lechi, Jonas Persson, Stefan Ståhl, John Löfblom, Olle Korsgren, Jonas Eriksson, Joey Lau, Olof Eriksson
Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1 diabetes, but widespread application is challenging due to shortages of donor tissue and the need for continuous immunosuppressive treatments. Stem-cell-derived islets have been suggested as an alternative source of beta cells, but face transplantation protocols optimization
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Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat EJNMMI Res. (IF 3.2) Pub Date : 2023-12-11 Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Riemer H. J. A. Slart
The apolipoprotein E-deficient (apoE−/−) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. Recently, the apoE−/− rat has emerged as an alternative. With this study, we investigate the feasibility of using apoE−/− rats as an in vivo model for longitudinal atherosclerotic PET/CT imaging
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18F-FDG PET/CT-based deep learning radiomics predicts 5-years disease-free survival after failure to achieve pathologic complete response to neoadjuvant chemotherapy in breast cancer EJNMMI Res. (IF 3.2) Pub Date : 2023-12-06 Xingxing Zheng, Yuhong Huang, Yingyi Lin, Teng Zhu, Jiachen Zou, Shuxia Wang, Kun Wang
This study aimed to assess whether a combined model incorporating radiomic and depth features extracted from PET/CT can predict disease-free survival (DFS) in patients who failed to achieve pathologic complete response (pCR) after neoadjuvant chemotherapy. This study retrospectively included one hundred and five non-pCR patients. After a median follow-up of 71 months, 15 and 7 patients experienced
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Single time point quantitation of cerebral glucose metabolism by FDG-PET without arterial sampling EJNMMI Res. (IF 3.2) Pub Date : 2023-11-30 Paul Cumming, André H. Dias, Lars C. Gormsen, Allan K. Hansen, Ian Alberts, Axel Rominger, Ole L. Munk, Hasan Sari
Until recently, quantitation of the net influx of 2-[18F]fluorodeoxyglucose (FDG) to brain (Ki) and the cerebrometabolic rate for glucose (CMRglc) required serial arterial blood sampling in conjunction with dynamic positron emission tomography (PET) recordings. Recent technical innovations enable the identification of an image-derived input function (IDIF) from vascular structures, but are frequently
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[18F]FDG PET-MR characterization of aortitis in the IL1rn−/− mouse model of giant-cell arteritis EJNMMI Res. (IF 3.2) Pub Date : 2023-11-29 Samuel Deshayes, Caroline Baugé, Pierre-Antoine Dupont, Christophe Simard, Hanan Rida, Hubert de Boysson, Alain Manrique, Achille Aouba
Metabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate the preclinical model of aortitis in BALB/c IL1rn−/− mice using [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography–magnetic resonance (PET-MR), gamma counting and immunostaining. We used 15 first-generation specific and opportunistic pathogen-free (SOPF) 9-week-old
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Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies EJNMMI Res. (IF 3.2) Pub Date : 2023-11-25 Jade Fantin, Jérôme Toutain, Elodie A. Pérès, Benoit Bernay, Sarina Maya Mehani, Charly Helaine, Mickael Bourgeois, Carole Brunaud, Laurent Chazalviel, Julien Pontin, Aurélien Corroyer-Dulmont, Samuel Valable, Michel Cherel, Myriam Bernaudin
Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor microenvironment (TME) of BM and particularly hypoxia and redox state, known to play a role in tumor growth and treatment resistance with multimodal PET and MRI imaging, immunohistochemical and proteomic approaches in a human lung cancer (H2030-BrM3)-derived BM model in rats. First
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Biological efficacy of simulated radiolabeled Lipiodol® ultra-fluid and microspheres for various beta emitters: study based on VX2 tumors EJNMMI Res. (IF 3.2) Pub Date : 2023-11-23 Arnaud Dieudonné, Stéphanie Becker, Miguel Soares, Claire Hollenbeck, Marie-Christine De Goltstein, Pierre Vera, Robin Santus
Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of this study was to evaluate the distribution of Lipiodol® ultra-fluid and microspheres and to simulate their effectiveness with different beta emitters (90Y, 188Re, 32P, 166Ho, 131I, and 177Lu) on VX2 tumors implanted in the liver of 30 New Zealand rabbits. Twenty-three out of 30
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Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET EJNMMI Res. (IF 3.2) Pub Date : 2023-11-20 Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman, Marco de Bruyn
CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive biomarker for noninvasive PET imaging of immunotherapy response. Since the long half-life of antibodies preclude repeat imaging of CD103+ T cell dynamics early in therapy, we therefore here explored
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Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer EJNMMI Res. (IF 3.2) Pub Date : 2023-11-16 Hui Wang, Marianne Remke, Thomas Horn, Kristina Schwamborn, Yiyao Chen, Katja Steiger, Wilko Weichert, Hans-Jürgen Wester, Margret Schottelius, Wolfgang A. Weber, Matthias Eiber
Targeting prostate-specific membrane antigen (PSMA) has been highly successful for imaging and treatment of prostate cancer. However, heterogeneity in immunohistochemistry indicates limitations in the effect of imaging and radionuclide therapy of multifocal disease. 99mTc-PSMA-I&S is a γ-emitting probe, which can be used for intraoperative lesion detection and postsurgical autoradiography (ARG). We
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Characterisation of a novel [18F]FDG brain PET database and combination with a second database for optimising detection of focal abnormalities, using focal cortical dysplasia as an example EJNMMI Res. (IF 3.2) Pub Date : 2023-11-15 Sameer Omer Jin, Inés Mérida, Ioannis Stavropoulos, Robert D. C. Elwes, Tanya Lam, Eric Guedj, Nadine Girard, Nicolas Costes, Alexander Hammers
Brain [18F]FDG PET is used clinically mainly in the presurgical evaluation for epilepsy surgery and in the differential diagnosis of neurodegenerative disorders. While scans are usually interpreted visually on an individual basis, comparison against normative cohorts allows statistical assessment of abnormalities and potentially higher sensitivity for detecting abnormalities. Little work has been done
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An update on the use of image-derived input functions for human PET studies: new hopes or old illusions? EJNMMI Res. (IF 3.2) Pub Date : 2023-11-10 Tommaso Volpi, Lucia Maccioni, Maria Colpo, Giulia Debiasi, Amedeo Capotosti, Tommaso Ciceri, Richard E. Carson, Christine DeLorenzo, Andreas Hahn, Gitte Moos Knudsen, Adriaan A. Lammertsma, Julie C. Price, Vesna Sossi, Guobao Wang, Paolo Zanotti-Fregonara, Alessandra Bertoldo, Mattia Veronese
The need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research settings. Image-derived input function (IDIF) approaches have been proposed as a cost-effective and non-invasive alternative to gold-standard arterial sampling. However, this approach comes with its own limitations—partial volume effects and radiometabolite correction
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Adenosine-induced splenic switch-off on [15O]H2O PET perfusion for the assessment of vascular vasodilatation EJNMMI Res. (IF 3.2) Pub Date : 2023-11-09 Satu Irene Inkinen, Eero Hippeläinen, Valtteri Uusitalo
Splenic switch-off (SSO) is a marker of adequate adenosine-induced vasodilatation on cardiac magnetic resonance perfusion imaging. We evaluate the feasibility of quantitative assessment of SSO in myocardial positron emission tomography (PET) perfusion imaging using [15O]H2O. Thirty patients underwent [15O]H2O PET perfusion with adenosine stress. Time-activity curves, as averaged standardized uptake
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Effects of novel androgen receptor signaling inhibitors on PSMA PET signal intensity in patients with castrate-resistant prostate cancer: a prospective exploratory serial imaging study EJNMMI Res. (IF 3.2) Pub Date : 2023-10-30 Ida Sonni, Andrei Gafita, Lena M. Unterrainer, Rejah M. Alano, Stephanie Lira, John Shen, Alexandra Drakaki, Tristan Grogan, Matthew B. Rettig, Johannes Czernin, Jeremie Calais
PSMA expression is influenced by hormonal status. We evaluated changes in PSA and whole-body 68Ga-PSMA-11 PET/CT (WB-PSMA PET) after initiation of androgen receptor signaling inhibitors (ARSi). Prospectively enrolled patients with metastatic castration-resistant prostate cancer (mCRPC) initiating ARSi underwent serial PSA measurements and WB-PSMA PET at baseline, 1-week, and 3-months post-ARSi. We
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The remodeling of metabolic brain pattern in patients with extracranial diffuse large B-cell lymphoma EJNMMI Res. (IF 3.2) Pub Date : 2023-10-30 Junyi Liu, Ming Tang, Dongling Zhu, Ge Ruan, Sijuan Zou, Zhaoting Cheng, Xiaohua Zhu, Yuankai Zhu
Owing to the advances in diagnosis and therapy, survival or remission rates for lymphoma have improved prominently. Apart from the lymphoma- and chemotherapy-related somatic symptom burden, increasing attention has been drawn to the health-related quality of life. The application of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) has been routinely recommended
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Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline EJNMMI Res. (IF 3.2) Pub Date : 2023-10-27 Hayel Tuncel, Denise Visser, Tessa Timmers, Emma E. Wolters, Rik Ossenkoppele, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard, Sandeep S. V. Golla
Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained from different tracers could be used interchangeably and is irrespective of target tissue. However, the similarities or differences of R1 obtained from different PET tracers
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Baseline 18F-FDG PET/CT radiomics for prognosis prediction in diffuse large B cell lymphoma EJNMMI Res. (IF 3.2) Pub Date : 2023-10-26 Fenglian Jing, Yunuan Liu, Xinming Zhao, Na Wang, Meng Dai, Xiaolin Chen, Zhaoqi Zhang, Jingmian Zhang, Jianfang Wang, Yingchen Wang
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults. Standard treatment includes chemoimmunotherapy with R-CHOP or similar regimens. Despite treatment advancements, many patients with DLBCL experience refractory disease or relapse. While baseline 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) parameters have shown promise in predicting
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Quantitative and clinical implications of the EARL2 versus EARL1 [18F]FDG PET-CT performance standards in head and neck squamous cell carcinoma EJNMMI Res. (IF 3.2) Pub Date : 2023-10-25 Maurice C. Cox, Tijn Jurcka, Anne I. J. Arens, Maartje C. van Rijk, Johannes H. A. M. Kaanders, Sven van den Bosch
The EANM Research Ltd. (EARL) guidelines give recommendations for harmonization of [18F]FDG PET-CT image acquisition and reconstruction, aiming to ensure reproducibility of quantitative data between PET scanners. Recent technological advancements in PET-CT imaging resulted in an updated version of the EARL guidelines (EARL2). The aim of this study is to compare quantitative [18F]FDG uptake metrics
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Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction EJNMMI Res. (IF 3.2) Pub Date : 2023-10-12 Benjamin Wilk, Haris Smailovic, Rebecca Sullivan, Erik R. Sistermans, John Butler, Hannah Jago, Michael Kovacs, Gerald Wisenberg, Jonathan D. Thiessen, Frank S. Prato
After myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse cardiac remodeling. FDG PET is an imaging modality sensitive to inflammation as long as suppression protocols are observed while gadolinium enhanced MRI can be used to determine extracellular volume (ECV), a measure of fibrosis. In patients, glucose suppression is achieved variously
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Value of 18F-FDG-PET/CT radiomics combined with clinical variables in the differential diagnosis of malignant and benign vertebral compression fractures EJNMMI Res. (IF 3.2) Pub Date : 2023-10-11 Xun Wang, Dandan Zhou, Yu Kong, Nan Cheng, Ming Gao, Guqing Zhang, Junli Ma, Yueqin Chen, Shuang Ge
Vertebral compression fractures (VCFs) are common clinical problems that arise from various reasons. The differential diagnosis of benign and malignant VCFs is challenging. This study was designed to develop and validate a radiomics model to predict benign and malignant VCFs with 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT). Twenty-six features (9 PET features
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Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of diffuse large B-cell lymphoma patients to image reconstruction protocols EJNMMI Res. (IF 3.2) Pub Date : 2023-09-28 Maria C. Ferrández, Sandeep S. V. Golla, Jakoba J. Eertink, Bart M. de Vries, Sanne E. Wiegers, Gerben J. C. Zwezerijnen, Simone Pieplenbosch, Louise Schilder, Martijn W. Heymans, Josée M. Zijlstra, Ronald Boellaard
Convolutional neural networks (CNNs), applied to baseline [18F]-FDG PET/CT maximum intensity projections (MIPs), show potential for treatment outcome prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study is to investigate the robustness of CNN predictions to different image reconstruction protocols. Baseline [18F]FDG PET/CT scans were collected from 20 DLBCL patients. EARL1, EARL2
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Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography EJNMMI Res. (IF 3.2) Pub Date : 2023-09-27 Robert M. Bober, Richard V. Milani, Sergey M. Kachur, Daniel P. Morin
Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower. This value has been confirmed using the 3 most common myocardial perfusion agents (13N, 15O-H2O and 82Rb) incorporating various kinetic models on older 2D positron emission tomography (PET) systems
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Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements EJNMMI Res. (IF 3.2) Pub Date : 2023-09-26 Juela Cufe, Florian Gierse, Klaus P. Schäfers, Sven Hermann, Michael A. Schäfers, Philipp Backhaus, Florian Büther
Kinetic modelling of dynamic PET typically requires knowledge of the arterial radiotracer concentration (arterial input function, AIF). Its accurate determination is very difficult in mice. AIF measurements in an extracorporeal shunt can be performed; however, this introduces catheter dispersion. We propose a framework for extracorporeal dispersion correction and validated it by comparison to invasively
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Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction EJNMMI Res. (IF 3.2) Pub Date : 2023-09-25 Yao Lu, Jingjing Meng, Mingkai Yun, Marcus Hacker, Xiang Li, Xiaoli Zhang
Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-inflammatory activation. We aimed to investigate the hematopoietic-inflammatory activation and the outcome in categorized patients with primary myocardial infarction (PMI) versus RMI as well as chronic stable angina (CSA) by 18F-FDG PET. A total of 105 patients (88 males; 60.1 ± 9
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CYP3A4 inhibitors do not influence [68Ga]Ga-DOTA-TATE uptake in liver tissue EJNMMI Res. (IF 3.2) Pub Date : 2023-09-22 Youssef Chahid, Faouzi Chahid, Ewoudt van de Garde, Jan Booij, Hein J. Verberne, N. Harry Hendrikse
The use of the positron emission tomography (PET) tracer [68 Ga]Ga-DOTA-TATE for somatostatin receptor (SSTR) imaging is common in patients with neuroendocrine tumours (NETs) [1]. PET-SSTR is indicated for various purposes, including initial staging at diagnosis, primary tumour localization, staging before surgery, patient selection for peptide receptor radionuclide therapy (PRRT), and post-PRRT studies
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Threshold for defining PSMA-positivity prior to 177Lu-PSMA therapy: a comparison of [68Ga]Ga-PSMA-11 and [18F]F-DCFPyL in metastatic prostate cancer EJNMMI Res. (IF 3.2) Pub Date : 2023-09-20 Jan Heilinger, Jasmin Weindler, Katrin Sabine Roth, Philipp Krapf, Klaus Schomäcker, Markus Dietlein, Alexander Drzezga, Carsten Kobe
In 2022, the American Food and Drug Administration and the European Medicines Agency approved [177Lu]Lu-PSMA-617 (PLUVICTO™, Novartis AG, Basel, Switzerland) for radionuclide therapy with prostate-specific membrane antigen (PSMA) ligands in metastatic prostate cancer. Theranostics require appropriate patients to be identified by positron emission tomography (PET) prior to radionuclide therapy, usually
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Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus EJNMMI Res. (IF 3.2) Pub Date : 2023-09-15 Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato, Yasuyuki Kimura
The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection areas such as the hippocampus. This diminishing noradrenaline availability is thought to play an important role pathophysiologically in the development of cognitive impairment in AD, because noradrenaline
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Fc-engineered monoclonal antibodies to reduce off-target liver uptake EJNMMI Res. (IF 3.2) Pub Date : 2023-09-11 Tristan Mangeat, Matthieu Gracia, Alexandre Pichard, Sophie Poty, Pierre Martineau, Bruno Robert, Emmanuel Deshayes
Radiolabeled-antibodies usually display non-specific liver accumulation that may impair image analysis and antibody biodistribution. Here, we investigated whether Fc silencing influenced antibody biodistribution. We compared recombinant 89Zr-labeled antibodies (human IgG1 against different targets) with wild-type Fc and with mutated Fc (LALAPG triple mutation to prevent binding to Fc gamma receptors;
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3D-printed dual holder system for simultaneous rat PET scanning: design and influence on quantification EJNMMI Res. (IF 3.2) Pub Date : 2023-09-07 Caroline Bouillot, Sébastien Daligault, Radu Bolbos, Nicolas Costes, Luc Zimmer
The low throughout of small animal positron emission tomography (PET) images acquisitions represents a substantial limitation. The aims of this study were (i) to design a low-cost support for simultaneous dynamic PET scanning of two lying rats and (ii) to study its impact on brain image quantification. Accuracy of concentration measurement was 5.5% for one phantom in the field of view, and 5.7% for
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Impact of brain segmentation methods on regional metabolism quantification in 18F-FDG PET/MR analysis EJNMMI Res. (IF 3.2) Pub Date : 2023-09-05 Yi Shan, Shao-zhen Yan, Zhe Wang, Bi-xiao Cui, Hong-wei Yang, Jian-min Yuan, Ya-yan Yin, Feng Shi, Jie Lu
Accurate analysis of quantitative PET data plays a crucial role in studying small, specific brain structures. The integration of PET and MRI through an integrated PET/MR system presents an opportunity to leverage the benefits of precisely aligned structural MRI and molecular PET images in both spatial and temporal dimensions. However, in many clinical workflows, PET studies are often performed without
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First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study EJNMMI Res. (IF 3.2) Pub Date : 2023-09-04 Wolfgang Roll, Michael Müther, Guido Böning, Astrid Delker, Nils Warneke, Franz-Josef Gildehaus, Michael Schäfers, Walter Stummer, Reinhard Zeidler, Hans-Jürgen Reulen, Lars Stegger
Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic anhydrase XII and injected into the resection cavity offers a novel and promising strategy for improved tumor control. Three glioblastoma patients underwent tumor