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Evaluation of acute intravenous toxicity of HEPES: Is Good's buffer good and safe enough for clinical utilization in nuclear medicine? Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-03-09 Mohini Guleria, K.J. Pallavi, Pranjal P. Gujarathi, Tapas Das
Good's buffer or HEPES has advantages over other buffers commonly used in radiopharmaceutical preparation as it exhibits significantly lower complexation tendency with metal ions. However, use of HEPES buffer for radiolabeling reactions, meant for clinical applications, has been underrated due to the non-availability of sufficient toxicity data. The objective of the present study is to find the evidences
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Improved purification of cyclotron [68Ga]GaCl3 for the production of 68Ga radiopharmaceuticals Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-02-24 Ivan E. Wang, Allen F. Brooks, Mara Clark, Luke J. Morrissette, Peter J.H. Scott
Increased demand for NetSpot and Illuccix as requirement to receive the respective Lutathera and Pluvicto radiotherapies, and monitor subsequent response to treatment, have reinforced the need to develop alternative ways of producing gallium-68 (Ga). Building on our efforts to produce Ga in a liquid target on a GE PETtrace, the goal of this work is to modify the current GE Gallium Chloride cassette
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Serotonin transporter imaging agent as a probe for β-cells of pancreas Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-02-24 Yuli Sun, Guangwen Li, Haiyan Hong, Lin Zhu, Hank F. Kung, Yan Zhang, Jinxia Zhu
Diabetes mellitus (DM) is one of the major diseases in the world. Nuclear medicine imaging may be able to detect functional status of pancreatic β cells , which might elucidate the pathological mechanisms of diabetes and develop individualized treatment plans. In this study, we evaluated the ability of [I]ADAM, a serotonin transporter (SERT) imaging agent, as a probe for detecting pancreatic β-cell
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Development of a CCR2 targeted 18F-labeled radiotracer for atherosclerosis imaging with PET Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-02-23 Xiaohui Zhang, Lin Qiu, Debbie H. Sultan, Hannah P. Luehmann, Yanbo Yu, Xiuli Zhang, Gyu Seong Heo, Alexandria Li, Divangana Lahad, Shinji Rho, Zhude Tu, Yongjian Liu
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In vitro evaluation of [3H]PI-2620 and structural derivatives in non-Alzheimer's tauopathies Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-02-19 Cassis Varlow, Chester A. Mathis, Neil Vasdev
Alzheimer's disease (AD) and non-AD tauopathies such as chronic traumatic encephalopathy (CTE), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are characterized by the abnormal aggregation of three-repeat (3R) and/or four-repeat (4R) tau isoforms. Several tau-PET tracers have been applied for human imaging of AD and non-AD tauopathies including [F]PI-2620. Our objective is
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Biodistribution study of 211Pb progeny released from intravenously applied 223Ra labelled TiO2 nanoparticles in a mouse model Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-02-19 Michal Sakmár, Ján Kozempel, Jan Kučka, Tereza Janská, Matěj Štíbr, Martin Vlk, Luděk Šefc
Targeted alpha therapy is one of the most powerful therapeutical modalities available in nuclear medicine. It's therapeutic potency is based on the nuclides that emit one or several alpha particles providing strong and highly localized therapeutic effects. However, some of these radionuclides, like Ra or Ac decay in cascades, where the radioactive progeny originating from the consecutive alpha-decays
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Evaluation of targeting αVβ3 in breast cancers using RGD peptide-based agents Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-02-06 Anders Josefsson, Angel G. Cortez, Jing Yu, Sunipa Majumdar, Abhinav Bhise, Robert F. Hobbs, Jessie R. Nedrow
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Advancements in the development of radiopharmaceuticals for nuclear medicine applications in the treatment of bone metastases Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-02-03 Michael R. Dyer, Zhenghan Jing, Kathleen Duncan, Jacqueline Godbe, Monica Shokeen
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Imaging diabetic cardiomyopathy in a type 1 diabetic rat model using 18F-FEPPA PET Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-01-26 Hsin-Hua Hsieh, Pei-An Chu, Yu-Hsin Lin, Yu-Chieh Jill Kao, Yi-Hsiu Chung, Shih-Ting Hsu, Jia-Min Mo, Chun-Yi Wu, Shin-Lei Peng
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Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging. Comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-01-11 Vladimir Shalgunov, Sara Lopes van den Broek, Ida Vang Andersen, Nakul R. Raval, Gabriela Schäfer, Matthias Barz, Matthias M. Herth, Umberto M. Battisti
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Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-01-10 Amina Khalil, Sona Hakhverdyan, Pierre Cheung, Martin Bossart, Michael Wagner, Olof Eriksson, Irina Velikyan
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64Cu production via the 68Zn(p,nα)64Cu nuclear reaction: An untapped, cost-effective and high energy production route Nucl. Med. Biol. (IF 3.1) Pub Date : 2024-01-06 Bryce J.B. Nelson, Samantha Leier, John Wilson, Melinda Wuest, Jonathan Doupe, Jan D. Andersson, Frank Wuest
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Fully automated dual-run manufacturing of [11C]PIB on FASTlab Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-12-25 Manoj Nair, Yiu-Yin Cheung, Fei Liu, Mary Ellen Koran, Adam J. Rosenberg
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Chelation chemistry of manganese-52 for PET imaging applications Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-12-23 James M. Omweri, Volkan Tekin, Shefali Saini, Hailey A. Houson, Samith B. Jayawardana, Daniel A. Decato, Gayan B. Wijeratne, Suzanne E. Lapi
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Evaluation of a novel hexadentate 1,2-hydroxypyridinone-based acyclic chelate, HOPO-O6-C4, for 43Sc/47Sc, 68Ga, and 45Ti radiopharmaceuticals Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-12-22 Imma Carbo-Bague, Shefali Saini, Shelbie J. Cingoranelli, Patrick R.W.J. Davey, Marianna Tosato, Suzanne E. Lapi, Caterina F. Ramogida
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Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-12-07
Abstract not available
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Repeatability of brown adipose tissue activation measured by [18F]FDG PET after beta3-adrenergic stimuli in a mouse model Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-09-29 Daniele de Paula Faria, Cleinando Clemente da Silva Vera, Fabio Luiz Navarro Marques, Marcelo Tatit Sapienza
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Co-production of 155Tb and 152Tb irradiating 155Gd/151Eu tandem target with a medium energy α-particle beam Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-09-26 A.N. Moiseeva, K.A. Makoveeva, E.B. Furkina, M.N. German, I.A. Khomenko, A.L. Konevega, E.S. Kormazeva, V.I. Novikov, N.V. Aksenov, N.S. Gustova, R.A. Aliev
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Preparation and evaluation of 111In-labeled liposomes containing phosphatidylglycerol for detection of macrophages in atherosclerotic plaques Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-09-26 Masayuki Munekane, Hinako Mori, Nao Takada, Kohei Sano, Toshihide Yamasaki, Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake, Takahiro Mukai
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Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-09-21 Lauren A. McIntosh, Jonathan D. Burns, Evgeny E. Tereshatov, Riccardo Muzzioli, Kris Hagel, Noimat A. Jinadu, Laura A. McCann, Gabriela A. Picayo, Federica Pisaneschi, David Piwnica-Worms, Steven J. Schultz, Gabriel C. Tabacaru, Austin Abbott, Brooklyn Green, Travis Hankins, Andrew Hannaman, Bryan Harvey, Kylie Lofton, Robert Rider, Maxwell Sorensen, Sherry J. Yennello
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GTP1 metabolic stability assessment: A study of the tau PET tracer [18F]GTP1 Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-09-04 Jan Marik, Sharyl Rich, Gauri Deshmukh, Donglu Zhang, Jeff Tinianow, Jingwei Cai, Susan Wong, Sudheer Bobba, Kevin DeMent, Ning Liu, Jason Halladay, Sandra Sanabria-Bohórquez, Lionel Cheruzel, Cyrus Khojasteh
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Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3 Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-09-01 Maryam Oroujeni, Ekaterina A. Bezverkhniaia, Tianqi Xu, Yongsheng Liu, Evgenii V. Plotnikov, Susanne Klint, Eva Ryer, Ida Karlberg, Anna Orlova, Fredrik Y. Frejd, Vladimir Tolmachev
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Comparison of three 18F-labeled 2-nitroimidazoles for imaging hypoxia in breast cancer xenografts: [18F]FBNA, [18F]FAZA and [18F]FMISO Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-08-26 Sofia Nascimento dos Santos, Melinda Wuest, Hans-Sonke Jans, Jenilee Woodfield, Arian Pérez Nario, Daniel Krys, Jennifer Dufour, Darryl Glubrecht, Cody Bergman, Emerson Soares Bernardes, Frank Wuest
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Development of [18F]DASA-10 for enhanced imaging of pyruvate kinase M2 Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-08-22 Mustafa T. Kendirli, Rim Malek, Marina B. Silveira, Christopher Acosta, Shuwen Zhang, Carmen Azevedo, Sydney C. Nagy, Frezghi Habte, Michelle L. James, Lawrence D. Recht, Corinne Beinat
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Automated production of [68Ga]Ga-DOTA-exendin-4 via fractionated radionuclide generator elution on a cassette based synthesis module Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-08-18 Martin Kraihammer, Elisabeth von Guggenberg, Anton Amadeus Hörmann, Michael Gabriel, Clemens Decristoforo
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Imaging of cell death in malignancy: Targeting pathways or phenotypes? Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-08-13 Ivan Ho Shon, Philip J. Hogg
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Retraction notice to “Radiosynthesis and biological evaluation of fluorine-18 labeled N-acetylgalactosamine derivative [18F]FPGalNAc for PET imaging of asialoglycoprotein receptor-positive tumors”. [Nucl Med Biol 88–89 (2020) 1–9] Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-08-10 Penghui Sun, Yanjiang Han, Yun Zhu, Kongzhen Hu, Shun Huang, Jianer Tan, Meng Wang, Hubing Wu, Ganghua Tang
Abstract not available
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Characterization of a S1PR2 specific 11C-labeled radiotracer in streptozotocin-induced diabetic murine model Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-07-26 Hao Jiang, Tianyu Huang, Yanbo Yu, Charles Zhou, Lin Qiu, Hien Ngoc Mai, Robert J. Gropler, Robyn S. Klein, Zhude Tu
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Preclinical studies of a PARP targeted, Meitner-Auger emitting, theranostic radiopharmaceutical for metastatic ovarian cancer Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-07-19 S.L.V. Hoffman, J.C. Mixdorf, O. Kwon, T.R. Johnson, M. Makvandi, H. Lee, E. Aluicio-Sarduy, T.E. Barnhart, J.J. Jeffery, M.S. Patankar, J.W. Engle, B.P. Bednarz, P.A. Ellison
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Astatine-211-labeled aza-vesamicol derivatives as sigma receptor ligands for targeted alpha therapy Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-07-22 Kazuma Ogawa, Kota Nishizawa, Kohshin Washiyama, Masayuki Munekane, Takeshi Fuchigami, Hiroaki Echigo, Kenji Mishiro, Saki Hirata, Hiroshi Wakabayashi, Kazuhiro Takahashi, Seigo Kinuya
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Relative Biological Effectiveness (RBE) of [64Cu]Cu and [177Lu]Lu-NOTA-panitumumab F (ab')2 radioimmunotherapeutic agents vs. γ-radiation for decreasing the clonogenic survival in vitro of human pancreatic ductal adenocarcinoma (PDAC) cells Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-07-17 Amanda J. Boyle, Zhongli Cai, Siobhan O’Brien, Jennifer Crick, Stephane Angers, Raymond M. Reilly
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Integrin αvβ3 and EGFR dual-targeted [64Cu]Cu-NOTA-RGD-GE11 heterodimer for PET imaging in pancreatic cancer mouse model Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-07-16 Huiqiang Li, Wenhua Peng, Zhifei Zhen, Weifeng Zhang, Shuguang Liao, Xinyu Wu, Li Wang, Ang Xuan, Yongju Gao, Junling Xu
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Biokinetics, radiopharmacokinetics and estimation of the absorbed dose in healthy organs due to Technetium-99m transported in the core and on the surface of reconstituted high-density lipoprotein nanoparticles Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-06-22 Diana L. Pérez-Velasco, Enrique Morales-Avila, Blanca Ocampo-García, Eugenio Torres-García, Germán Izquierdo, Nallely Jiménez-Mancilla, Rigoberto Oros-Pantoja, Luis E. Díaz-Sánchez, Liliana Aranda-Lara, Keila Isaac-Olivé
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[18F]FDG and [11C]PK11195 PET imaging in the evaluation of brown adipose tissue - effects of cold and pharmacological stimuli and their association with crotamine intake in a male mouse model Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-06-17 Daniele de Paula Faria, Joana D'Arc Campeiro, Mara de Souza Junqueira, Caroline Cristiano Real, Fabio Luiz Navarro Marques, Mirian Akemi Furuie Hayashi, Marcelo Tatit Sapienza
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Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-06-14
Abstract not available
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Production and radiochemistry of antimony-120m: Efforts toward Auger electron therapy with 119Sb Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-06-12 Thomas I. Kostelnik, Aeli P. Olson, Aivija Grundmane, Paul A. Ellison, Jenasee Mynerich, Shaohuang Chen, Atanaska Marinova, Parmissa Randhawa, Dimitar Karaivanov, Eduardo Aluicio-Sarduy, Todd E. Barnhart, Chris Orvig, Caterina F. Ramogida, Cornelia Hoehr, Dmitry Filosofov, Jonathan W. Engle, Valery Radchenko
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Automated radiosynthesis of [89Zr]Zr-DFOSq-Durvalumab for imaging of PD-L1 expressing tumours in vivo Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-05-16 Christian W. Wichmann, Stan Poniger, Nancy Guo, Peter Roselt, Stacey E. Rudd, Paul S. Donnelly, Benjamin Blyth, Jessica Van Zuylekom, Angela Rigopoulos, Ingrid J.G. Burvenich, Laurence Morandeau, Shifaza Mohamed, Anna Nowak, Fiona Hegi-Johnson, Michael MacManus, Andrew M. Scott
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Visualization research on ENT1/NIS dual-function gene therapy to reverse drug resistance mediated by MUC1 in GEM-resistant pancreatic cancer Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-05-08 Yun Xi, Hong Chen, Yue Xi, Wangxi Hai, Qian Qu, Min Zhang, Biao Li
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Synthesis and preclinical evaluation of two osimertinib isotopologues labeled with carbon-11 as PET tracers targeting the tyrosine kinase domain of the epidermal growth factor receptor Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-05-04 Antonia Högnäsbacka, Alex J. Poot, Esther Kooijman, Robert C. Schuit, Maxime Schreurs, Mariska Verlaan, Johan van den Hoek, Daniëlle A.M. Heideman, Wissam Beaino, Guus A.M.S. van Dongen, Danielle J. Vugts, Albert D. Windhorst
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The emerging role of artificial intelligence and digital twins in pre-clinical molecular imaging Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-04-04 Geoffrey M. Currie
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In vivo validation of 68Ga-labeled AMD3100 conjugates for PET imaging of CXCR4 Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-04-05 Isaline Renard, Juozas Domarkas, Sophie Poty, Benjamin P. Burke, David P. Roberts, Christine Goze, Franck Denat, Christopher J. Cawthorne, Stephen J. Archibald
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Imaging of microglia in post-stroke inflammation Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-03-31 Ze Wang, Yaying Song, Shuwei Bai, Weiwei Xiang, Xiajun Zhou, Lu Han, Desheng Zhu, Yangtai Guan
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Direct comparison of [18F]AlF-NOTA-JR11 and [18F]AlF-NOTA-octreotide for PET imaging of neuroendocrine tumors: Antagonist versus agonist Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-03-29 Stephen Ahenkorah, Christopher Cawthorne, Erika Murce, Christophe M. Deroose, Thomas Cardinaels, Yann Seimbille, Guy Bormans, Maarten Ooms, Frederik Cleeren
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Deuterated [18F]fluoroethyl tropane analogs as dopamine transporter probes: Synthesis and biological evaluation Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-03-24 Qingming Li, Qianyue Hu, Jie Tang, Yi Fang, Chunyi Liu, Jie Liu, Meihui Qi, Zhengping Chen, Ling Zhang
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Preparation and labelling of red blood cells with [68Ga]Ga-oxine for PET/CT imaging of the human spleen Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-03-15 Robert Drescher, Sebastian Gröber, Martin Freesmeyer, Julia Greiser
Introduction With the introduction of automated synthetization methods, the in-house production of several 68Ga-based tracers became feasible in hospital laboratories. We describe a possible standard operating procedure (SOP) for [68Ga]Ga-oxine-labeled heat-denaturated erythrocytes, which can be used for selective imaging in patients with splenic disorders. Methods Heat-denaturated erythrocytes were
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[99mTc]Tc-HYNIC-RM2: A potential SPECT probe targeting GRPR expression in prostate cancers Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-03-10 Kusum Vats, Avik Chakraborty, Sutapa Rakshit, Archana Damle, Haladhar Dev Sarma, Drishty Satpati
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Biological evaluation of a novel stable peptide PET molecular probe [18F]AlF-NOTA-DVAP targeting to tumor cell surface GRP78 Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-02-28 Bolin Yao, Luting Wang, Cao Xie, Ming Li, Chengyuan Peng, Zhuoyun Li, Weiyue Lu, Jian Chen
Backgrounds Glucose-Regulated Protein 78 (GRP78) is an attractive anticancer target for its selective anchoring on the surface of tumor cells and cancer endothelial cells rather than normal cells. Cell-surface GRP78 overexpression of tumor indicates that GRP78 is a crucial target for relative tumor imaging and clinical treatment. Herein, we report the design and preclinical evaluation of a new D peptide
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Theranostic cobalt-55/58m for neurotensin receptor-mediated radiotherapy in vivo: A pilot study with dosimetry Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-02-13 Wilson Lin, Eduardo Aluicio-Sarduy, Hailey A. Houson, Todd E. Barnhart, Volkan Tekin, Justin J. Jeffery, Ashley M. Weichmann, Kendall E. Barrett, Suzanne E. Lapi, Jonathan W. Engle
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Cyclotron production of 103Pd using a liquid target Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-02-09 Viktoria Krol, Lucas Mues gennant Koers, Scott McNeil, Cornelia Hoehr, Valery Radchenko
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Automated production of [11C]butyrate for keto body PET imaging Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-01-13 Ryan J. Pakula, David M. Raffel, Robert A. Koeppe, Wade P. Winton, Jenelle Stauff, Nicolaas I. Bohnen, Roger L. Albin, Peter J.H. Scott, Xia Shao
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High-yield cyclotron production of 203Pb using a sealed 205Tl solid target Nucl. Med. Biol. (IF 3.1) Pub Date : 2023-01-13 Bryce J.B. Nelson, John Wilson, Michael K. Schultz, Jan D. Andersson, Frank Wuest
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Comparison of the synthesis and biological properties of no-carrier-added and carrier-added 4-borono-2-[18F]fluorophenylalanine ([18F]FBPA) Nucl. Med. Biol. (IF 3.1) Pub Date : 2022-12-30 Ting-Yu Chang, Wen-Yi Chang, Yi-Wei Chen, Ming-Che Ho, Chi-Wei Chang, Sie-Ong Lau, Nan-Jing Peng, Chun-Yi Wu
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A radioiodinated rucaparib analogue as an Auger electron emitter for cancer therapy Nucl. Med. Biol. (IF 3.1) Pub Date : 2022-12-28 Gianluca Destro, Zijun Chen, Chung Ying Chan, Claudia Fraser, Gemma Dias, Michael Mosley, Florian Guibbal, Veronique Gouverneur, Bart Cornelissen
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Evaluation of sulfone-labeled amino acid derivatives as potential PET agents for cancer imaging Nucl. Med. Biol. (IF 3.1) Pub Date : 2022-12-24 Mei Hu, Liping Yang, Nan Liu, Ruiling Long, Liu Zhou, Weiling Zhao, Yue Feng, Changjiang Wang, Zibo Li, Yue Chen, Li Wang
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Synthesis, radiolabeling, and preclinical in vivo evaluation of 68Ga-radiolabelled nanodiamonds Nucl. Med. Biol. (IF 3.1) Pub Date : 2022-12-20 Thomas Wanek, Severin Mairinger, Marco Raabe, Md Noor A. Alam, Thomas Filip, Johann Stanek, Gordon Winter, Lujuan Xu, Christian Laube, Tanja Weil, Volker Rasche, Claudia Kuntner