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Modeling of a tissue expander with a radiofrequency identification port in postmastectomy radiation therapy planning J. Radiat. Res. (IF 2.0) Pub Date : 2024-03-10 Fumiyasu Matsubayashi, Taro Takahashi, Hikaru Miyauchi, Yasushi Ito, Arisa Harada, Yasuo Yoshioka
The purpose of this study was to evaluate the dose attenuation of Motiva Flora® (Flora, Establishment Labs, Alajuela, Costa Rica) tissue expander with a radiofrequency identification port locator and to develop a model for accurate postmastectomy radiation therapy planning. Dose attenuation was measured using an EBT3 film (Ashland, Bridgewater, NJ), and the optimal material and density assignment for
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Inhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation J. Radiat. Res. (IF 2.0) Pub Date : 2024-03-10 Ryota Hayashi, Hikaru Okumura, Mayu Isono, Motohiro Yamauchi, Daiki Unami, Rahmartani Tania Lusi, Masamichi Yamamoto, Yu Kato, Yuki Uchihara, Atsushi Shibata
Ionizing radiation (IR)-induced double-strand breaks (DSBs) are primarily repaired by non-homologous end joining or homologous recombination (HR) in human cells. DSB repair requires adenosine-5′-triphosphate (ATP) for protein kinase activities in the multiple steps of DSB repair, such as DNA ligation, chromatin remodeling, and DNA damage signaling via protein kinase and ATPase activities. To investigate
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MHY1485 potentiates immunogenic cell death induction and anti-cancer immunity following irradiation J. Radiat. Res. (IF 2.0) Pub Date : 2024-02-08 Lue Sun, Kumi Morikawa, Yu Sogo, Yuki Sugiura
Recent in vitro experiments showed that combined treatment with MHY1485, a low-molecular-weight compound, and X-ray irradiation significantly increased apoptosis and senescence in tumor cells, which was associated with oxidative stress, endoplasmic reticulum (ER) stress and p21 stabilization, compared to radiation treatment alone. However, evidence for MHY1485 treatment-mediated suppression of tumor
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The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in breast cancer patients J. Radiat. Res. (IF 2.0) Pub Date : 2024-02-07 Hisashi Yamaguchi, Nobuyoshi Fukumitsu, Haruko Numajiri, Hiroyuki Ogino, Tomoaki Okimoto, Takashi Ogino, Motohisa Suzuki, Shigeyuki Murayama
A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis in breast cancers. Cases in which PBT was performed at all Japanese proton therapy facilities between May 2016 and February 2019 were enrolled. The patients were selected based on the
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Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans J. Radiat. Res. (IF 2.0) Pub Date : 2024-01-24 Takuya Uehara, Yasumasa Nishimura, Kazuki Ishikawa, Masahiro Inada, Kenji Matsumoto, Hiroshi Doi, Hajime Monzen, Yukinori Matsuo
The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled
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Application of a derivative of human defensin 5 to treat ionizing radiation-induced enterogenic infection J. Radiat. Res. (IF 2.0) Pub Date : 2024-01-24 Gaomei Zhao, Yingjuan He, Yin Chen, Yiyi Jiang, Chenwenya Li, Tainong Xiong, Songling Han, Yongwu He, Jining Gao, Yongping Su, Junping Wang, Cheng Wang
Enterogenic infection is a common complication for patients with radiation injury and requires efficient therapeutics in the clinic. Herein, we evaluated the promising drug candidate T7E21RHD5, which is a peptide derived from intestinal Paneth cell-secreted human defensin 5. Oral administration of this peptide alleviated the diarrhea symptoms of mice that received total abdominal irradiation (TAI,
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An analysis of muscle growth after proton beam therapy for pediatric cancer J. Radiat. Res. (IF 2.0) Pub Date : 2024-01-24 Hazuki Nitta, Masashi Mizumoto, Yinuo Li, Yoshiko Oshiro, Hiroko Fukushima, Ryoko Suzuki, Sho Hosaka, Takashi Saito, Haruko Numajiri, Chie Kawano, Satoshi Kamizawa, Kazushi Maruo, Hideyuki Sakurai
Retardation of growth and development is a well-known late effect after radiotherapy for pediatric patients. The goal of the study was to examine the effect of proton beam therapy (PBT) on the growth of muscles included in the irradiated area. The subjects were 17 pediatric patients (age ≤ 5 years) who received PBT with a treatment field including a muscle on only one side out of a pair of symmetrical
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Enhanced induction of abnormal telomere FISH signals in response to oxidative DNA damage J. Radiat. Res. (IF 2.0) Pub Date : 2024-01-04 Yoshimi Sakamoto, Kazunori Shiraishi, Seiji Kodama
Telomere dysfunction induces chromosomal instability, which is a driving force in the development of cancers. To examine X-irradiation’s effect on telomere integrity, we investigated X-ray-induced abnormalities in telomere signals detected by fluorescence in situ hybridization (telomere FISH) in mouse embryo fibroblast cells. The abnormalities were categorized as either extra telomere signals (ETSs)
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Radiological imaging protection: a study on imaging dose used while planning computed tomography for external radiotherapy in Japan J. Radiat. Res. (IF 2.0) Pub Date : 2023-12-28 Satoshi Kito, Yuhi Suda, Satoshi Tanabe, Takeshi Takizawa, Tomomasa Nagahata, Naoki Tohyama, Hiroyuki Okamoto, Takumi Kodama, Yukio Fujita, Hisayuki Miyashita, Kazuya Shinoda, Masahiko Kurooka, Hidetoshi Shimizu, Takeshi Ohno, Masataka Sakamoto
Previous studies have primarily focused on quality of imaging in radiotherapy planning computed tomography (RTCT), with few investigations on imaging doses. To our knowledge, this is the first study aimed to investigate the imaging dose in RTCT to determine baseline data for establishing national diagnostic reference levels (DRLs) in Japanese institutions. A survey questionnaire was sent to domestic
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Mechanistic insights into the survival curve of HeLa cells with a short shoulder and their S phase-specific sensitivity J. Radiat. Res. (IF 2.0) Pub Date : 2023-12-28 Kenshi Komatsu, Hiroshi Tauchi
HeLa cells are a cell line with two unique cellular features: a short-shouldered survival curve and two peaks of radioresistance during the cell cycle phase, while their underlying mechanisms remain unclear. We herein proposed that these radiobiological features are due to a common mechanism by which radiation suppresses homologous recombination repair (HRR) in a dose-dependent manner. This radio-suppression
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The potential overdose of heart and left anterior descending coronary artery region during intensity-modulated radiation therapy in patients with esophageal cancer J. Radiat. Res. (IF 2.0) Pub Date : 2023-12-28 Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki
This study aimed to investigate the changes in dose distribution in the heart and left anterior descending coronary artery region (LADR) during intensity-modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated at our institution. The heart and LADR were delineated on the initial and off-cord boost planning computed tomography (CT) images. Cardiac volume reduction (CVR) was
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Patterns of care for brachytherapy in Japan J. Radiat. Res. (IF 2.0) Pub Date : 2023-12-28 Hitoshi Ikushima, Noriko Ii, Shin-ei Noda, Koji Masui, Naoya Murakami, Ken Yoshida, Miho Watanabe, Shinnji Kawamura, Toru Kojima, Yoshihito Nomoto, Takafumi Toita, Tatsuya Ohno, Hideyuki Sakurai, Hiroshi Onishi
This study aimed to assess the current state of brachytherapy (BT) resources, practices and resident education in Japan. A nationwide survey was undertaken encompassing 177 establishments facilitating BT in 2022. Questionnaires were disseminated to each BT center, and feedback through online channels or postal correspondence was obtained. The questionnaire response rate was 90% (159/177), and every
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VMAT with DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery: results of a non-inferiority clinical study J. Radiat. Res. (IF 2.0) Pub Date : 2023-12-13 Keiichi Jingu, Kengo Ito, Kiyokazu Sato, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Hinako Harada, Yasuhiro Seki, Nanae Chiba, Noriyuki Kadoya
The purpose of this study was to show the safety of volumetric modulated arc therapy (VMAT) with deep inspiration breath-hold (DIBH) in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery in a clinical setting. Twenty-five Japanese women, aged 20–59 years, who were enrolled in this prospective non-inferiority study received VMAT under the condition of DIBH with
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An investigation into the impact of volumetric rescanning and fractionation treatment on dose homogeneity in liver cancer proton therapy. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-29 Pei-Yi Lee,Bing-Shen Huang,Shen-Hao Lee,Tsz-Yui Chan,Eric Yen,Tsair-Fwu Lee,I-Chun Cho
The Pencil Beam Scanning (PBS) technique in modern particle therapy offers a highly conformal dose distribution but poses challenges due to the interplay effect, an interaction between respiration-induced organ movement and PBS. This study evaluates the effectiveness of different volumetric rescanning strategies in mitigating this effect in liver cancer proton therapy. We used a Geant4-based Monte
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Development of local-power-free, remote α-particle detection using optical fibers. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-29 Kent B Pfeifer,Thomas M Weber,James E Martin
We demonstrate the application of fluorescence optical fiber coupled to a telecom grade fiber as a sensor for alpha particles using alpha-specific ZnS(Ag) scintillation materials whose wavelength is down-shifted into a low-loss region of the telecom grade fiber transmission band. Telecom-grade fiber optics offer a solution for sensing alpha radiation in deep repositories and cask storage for radioactive
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Clinical outcomes of scalp or face angiosarcoma treatment with intensity-modulated radiotherapy: a multicenter study J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-24 Takahiro Iwai, Toshiyuki Imagumbai, Shinya Hiraoka, Takahiro Kishi, Shun Okabayashi, Ryo Ashida, Takamasa Mitsuyoshi, Yukinori Matsuo, Takashi Ishigaki, Takashi Mizowaki, Masaki Kokubo
Combined modality therapy, including radiotherapy (RT), is a common treatment for scalp or face angiosarcoma. Although intensity-modulated radiotherapy (IMRT) can deliver homogeneous doses to the scalp or face, clinical data are limited. This multicenter study aimed to evaluate scalp or face angiosarcoma treated with definitive or post-operative IMRT. We retrospectively analyzed data from patients
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A multivariable normal tissue complication probability model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma patients in the modern radiotherapy era J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-24 Siriporn Wongwattananard, Anussara Prayongrat, Natchalee Srimaneekarn, Anthony Hayter, Jiratchaya Sophonphan, Seksan Kiatsupaibul, Puvarith Veerabulyarith, Yothin Rakvongthai, Napat Ritlumlert, Sarin Kitpanit, Danita Kannarunimit, Chawalit Lertbutsayanukul, Chakkapong Chakkabat
Radiation-induced hypothyroidism (RHT) is a common long-term complication for nasopharyngeal carcinoma (NPC) survivors. A model using clinical and dosimetric factors for predicting risk of RHT could suggest a proper dose–volume parameters for the treatment planning in an individual level. We aim to develop a multivariable normal tissue complication probability (NTCP) model for RHT in NPC patients after
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Dosimetric verification of four dose calculation algorithms for spine stereotactic body radiotherapy. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-22 Hideaki Hirashima,Mitsuhiro Nakamura,Kiyonao Nakamura,Yukinori Matsuo,Takashi Mizowaki
The applications of Type B [anisotropic analytical algorithm (AAA) and collapsed cone (CC)] and Type C [Acuros XB (AXB) and photon Monte Carlo (PMC)] dose calculation algorithms in spine stereotactic body radiotherapy (SBRT) were evaluated. Water- and bone-equivalent phantoms were combined to evaluate the percentage depth dose and dose profile. Subsequently, 48 consecutive patients with clinical spine
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Revolutionizing radiation therapy: the role of AI in clinical practice. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-22 Mariko Kawamura,Takeshi Kamomae,Masahiro Yanagawa,Koji Kamagata,Shohei Fujita,Daiju Ueda,Yusuke Matsui,Yasutaka Fushimi,Tomoyuki Fujioka,Taiki Nozaki,Akira Yamada,Kenji Hirata,Rintaro Ito,Noriyuki Fujima,Fuminari Tatsugami,Takeshi Nakaura,Takahiro Tsuboyama,Shinji Naganawa
This review provides an overview of the application of artificial intelligence (AI) in radiation therapy (RT) from a radiation oncologist's perspective. Over the years, advances in diagnostic imaging have significantly improved the efficiency and effectiveness of radiotherapy. The introduction of AI has further optimized the segmentation of tumors and organs at risk, thereby saving considerable time
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Role of microbiota in radiation-induced small-bowel damage. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-22 Yi-Fan Chen,Sung-Chou Li,Eng-Yen Huang
Radiation-induced gastrointestinal damage is a common acute radiation syndrome. Previous studies have highlighted that Galectin-1 and Interleukin-6 (IL-6) are associated with flaking of small intestinal villi and intestinal radioresistance. Therefore, our goal is to study whether gut bacteria regulated by galectin-1 or IL-6 can mitigate radiation-induced small intestine damage. In this study, differences
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Current status of remote radiotherapy treatment planning in Japan: findings from a national survey†. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-22 Masahide Saito,Tetsuro Tamamoto,Shohei Kawashiro,Rei Umezawa,Masaki Matsuda,Naoki Tohyama,Yoshiyuki Katsuta,Takayuki Kanai,Hikaru Nemoto,Hiroshi Onishi
The purpose of this study was to investigate the status of remote-radiotherapy treatment planning (RRTP) in Japan through a nationwide questionnaire survey. The survey was conducted between 29 June and 4 August 2022, at 834 facilities in Japan that were equipped with linear accelerators. The survey utilized a Google form that comprised 96 questions on facility information, information about the respondent
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Real-time tumor-tracking radiotherapy with SyncTraX for primary liver tumors requiring isocenter shift†. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-22 Yusuke Uchinami,Naoki Miyamoto,Daisuke Abo,Ryo Morita,Koji Ogawa,Tatsuhiko Kakisaka,Ryusuke Suzuki,Tomohiko Miyazaki,Hiroshi Taguchi,Norio Katoh,Hidefumi Aoyama
The SyncTraX series enables real-time tumor-tracking radiotherapy through the real-time recognition of a fiducial marker using fluoroscopic images. In this system, the isocenter should be located within approximately 5-7.5 cm from the marker, depending on the version, owing to the limited field of view. If the marker is placed away from the tumor, the isocenter should be shifted toward the marker.
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Long-term outcomes of stimulated salivary flow and xerostomia after definitive intensity-modulated radiation therapy for patients with head and neck cancer†. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-22 Shinya Hiraoka,Michio Yoshimura,Aya Nakajima,Ryota Nakashima,Takashi Mizowaki
This retrospective study aimed to evaluate the time to recovery from xerostomia and analyze its predictors, along with long-term outcomes of stimulated salivary flow after intensity-modulated radiation therapy (IMRT) for head and neck cancer (HNC). We evaluated patients with HNC who had received IMRT with curative intent between 2012 and 2018 at our institution. The salivary recovery ratio (SRR) was
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The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in esophagogastric cancer patients. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Hisashi Yamaguchi,Nobuyoshi Fukumitsu,Haruko Numajiri,Hiroyuki Ogino,Norio Katoh,Tomoaki Okimoto,Motohisa Suzuki,Hideyuki Sakurai
A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis of esophagogastric cancers. Cases in which PBT was performed at all PBT facilities in Japan between May 2016 and February 2019 were enrolled. The patients were selected based on the
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Current status and issues with the dosimetric assay of iodine-125 seed sources at medical facilities in Japan: a questionnaire-based survey†. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Toru Kojima,Shinji Kawamura,Yuki Otani,Takashi Hanada,Yuichiro Wakitani,Kenta Naniwa,Atsunori Yorozu,Hitoshi Ikushima,Takushi Dokiya
In conducting dosimetric assays of seed sources containing iodine-125 (125I), several major guidelines require the medical physicist to verify the source strength before patient treatment. Japanese guidelines do not mandate dosimetric assays at medical facilities, but since 2017, three incidents have occurred in Japan wherein seeds with incorrect strengths were delivered to medical facilities. Therefore
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Therapeutic mechanism of Liangxue-Guyuan-Yishen decoction on intestinal stem cells and tight junction proteins in gastrointestinal acute radiation syndrome rats. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Ziqiao Yan,Bofeng Yin,Yuguo Wang,Zhexin Ni,Jian Feng,Qianyu Yang,Xiao Li,Heng Zhu,Yongqi Dou
On the basis of the previous research, the Traditional Chinese Medicine theory was used to improve the drug composition for gastrointestinal acute radiation syndrome (GI-ARS). The purpose of this study was to study the therapeutic mechanism of Liangxue-Guyuan-Yishen decoction (LGYD) on GI-ARS and to provide a new scheme for the treatment of radiation injury. Here, we investigated the effects of LGYD
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Prediction of late adverse events in pelvic cancer patients receiving definitive radiotherapy using radiation-induced gamma-H2AX foci assay. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Masanori Someya,Tomokazu Hasegawa,Asako J Nakamura,Takaaki Tsuchiya,Mio Kitagawa,Toshio Gocho,Sho Mafune,Yutaro Ikeuchi,Hiroshi Tauchi,Koh-Ichi Sakata
Radiation can induce DNA double-stranded breaks, which are typically detected by the fluorescence of phosphorylated histone H2AX. In this study, we examined the usefulness of the dynamics of radiation-induced gamma-H2AX foci of peripheral blood lymphocytes (PBLs), as a marker of DNA repair ability, in predicting late adverse events from radiotherapy. A total of 46 patients with cervical, vaginal and
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Evaluations of patient-specific bolus fabricated by mold-and-cast method using computer numerical control machine tools†. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Geum Bong Yu,Jimin Kwon,Seunghoon Chae,Sung Young Lee,Seongmoon Jung
The patient-specific bolus fabricated by a mold-and-cast method using a 3D printer (3DP) and silicon rubber has been adopted in clinical practices. Manufacturing a mold using 3DP, however, can cause time delays due to failures during the 3D printing process. Thereby, we investigated an alternative method of the mold fabrication using computer numerical control (CNC) machine tools. Treatment plans were
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Dual-energy computed tomography-based iodine concentration as a predictor of histopathological response to preoperative chemoradiotherapy for pancreatic cancer. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Shingo Ohira,Toshiki Ikawa,Naoyuki Kanayama,Masanari Minamitani,Sayaka Kihara,Shoki Inui,Yoshihiro Ueda,Masayoshi Miyazaki,Hideomi Yamashita,Teiji Nishio,Masahiko Koizumi,Keiichi Nakagawa,Koji Konishi
To explore predictors of the histopathological response to preoperative chemoradiotherapy (CRT) in patients with pancreatic cancer (PC) using dual-energy computed tomography-reconstructed images. This retrospective study divided 40 patients who had undergone preoperative CRT (50-60 Gy in 25 fractions) followed by surgical resection into two groups: the response group (Grades II, III and IV, evaluated
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Assessment of intrafractional motion of the cervix-uterus by MR-guided radiotherapy system†. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Ayaka Nagao,Hiroyuki Okamoto,Hiroki Nakayama,Takahito Chiba,Daisuke Fujiyama,Junichi Kuwahara,Tatsuya Sakasai,Tairo Kashihara,Tomoya Kaneda,Koji Inaba,Kae Okuma,Naoya Murakami,Hiroshi Igaki
The uterus is known as one of the moving organs. We evaluated the movement of the uterus during irradiation and the effects of changes in the surrounding organs using a magnetic resonance (MR)-guided radiotherapy system. Seven patients with cervical cancer underwent pre- and posttreatment MR imaging to assess changes in the positioning of the uterus and cervix as well as the alterations in bladder
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MTDH enhances radiosensitivity of head and neck squamous cell carcinoma by promoting ferroptosis based on a prognostic signature J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-20 Xiang Cao, Yizhi Ge, Zhenyu Yan, Xinyu Hu, Fanyu Peng, Yujie Zhang, Xia He, Dan Zong
Ionizing radiation (IR) induces ferroptosis in head and neck squamous cell carcinoma (HNSCC). But, it remains unclear whether ferroptosis affects the prognosis of HNSCC patients after receiving radiotherapy. This study aims to develop a ferroptosis signature to predict the radiosensitivity and prognosis of HNSCC. Ferroptosis-related genes, clinical data and RNA expression profiles were obtained from
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Comparison of external dose estimates using different retrospective dosimetry methods in the settlements located near Semipalatinsk Nuclear Test Site, Republic of Kazakhstan J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-20 Valeriy Stepanenko, Sergey Shinkarev, Andrey Kaprin, Kazbek Apsalikov, Sergey Ivanov, Peter Shegay, Evgenia Ostroumova, Ausrele Kesminiene, Alexandra Lipikhina, Viktoria Bogacheva, Kassym Zhumadilov, Masayoshi Yamamoto, Aya Sakaguchi, Satoru Endo, Nariaki Fujimoto, Bernd Grosche, Vladimir Iatsenko, Alla Androsova, Zukhra Apsalikova, Noriyuki Kawano, Masaharu Hoshi
For correct assessment of health risks after low-dose irradiation, calculation of radiation exposure estimates is crucial. To verify the calculated absorbed doses, instrumental methods of retrospective dosimetry are used. We compared calculated and instrumental-based estimates of external absorbed doses in the residents of Dolon, Mostik and Cheremushki villages, Kazakhstan, affected by the first nuclear
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Daily fraction dose-adjusted radiotherapy policy to avoid prolonging the overall treatment time for early glottic squamous cell carcinoma: a single-institutional retrospective study. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-10 Yasuhiro Dekura,Koichi Yasuda,Hideki Minatogawa,Yusuke Uchinami,Nayuta Tsushima,Takayoshi Suzuki,Satoshi Kano,Takashi Mori,Kentaro Nishioka,Keiji Kobashi,Norio Katoh,Akihiro Homma,Hidefumi Aoyama
The objective of this study was to determine the outcomes of radical radiotherapy for early glottic squamous cell carcinoma (EGSCC) with the policy of increasing the fraction size during radiotherapy when the overall treatment time (OTT) was expected to be prolonged. Patients diagnosed with clinical T1-2N0M0 EGSCC, who were treated with radical radiotherapy between 2008 and 2019 at Hokkaido University
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Ultrasound-mediated delivery of Pik3cb shRNA using magnetic nanoparticles for the treatment of in-stent restenosis in a rat balloon-injured model J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-10 Yuhao Wang, Miao Li, Zongxiang Sheng, Hong Ran, Jing Dong, Lingling Fang, Pingyang Zhang
The aim of the present work was to examine the effect of polyethylene glycol (PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles carrying Pik3cb short hairpin RNA (shRNA) in the prevention of restenosis with the aid of ultrasound and a magnetic field. SPIO is a type of contrast agent used in medical imaging to enhance the visibility of specific tissues or organs. It consists of tiny iron
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Gamma-irradiated Aspergillus conidia show a growth curve with a reproductive death phase J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-10 Shigetoshi Horikiri, Mami Harada, Ryoko Asada, Tetsuaki Tsuchido, Masakazu Furuta
In this study, we evaluated the effects of gamma irradiation on the germination of Aspergillus conidia and mycelial growth using microscopy and predictive microbiological modeling methods. A dose of 0.4 kGy reduced the germination rate by 20% compared to the untreated control, indicating interphase death due to the high radiation dose. The number of colonies formed (5.5%) was lower than the germination
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A national survey on the medical physics workload of external beam radiotherapy in Japan J. Radiat. Res. (IF 2.0) Pub Date : 2023-10-11 Naoki Tohyama, Hiroyuki Okamoto, Kohei Shimomura, Masahiko Kurooka, Ryu Kawamorita, Seiichi Ota, Toru Kojima, Naoki Hayashi, Masahiko Okumura, Masaru Nakamura, Mitsuhiro Nakamura, Atsushi Myojoyama, Hiroshi Onishi
Several staffing models are used to determine the required medical physics staffing, including radiotherapy technologists, of radiation oncology departments. However, since Japanese facilities tend to be smaller in scale than foreign ones, those models might not apply to Japan. Therefore, in this study, we surveyed workloads in Japan to estimate the optimal medical physics staffing in external beam
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Thyroid cancer risk after radiation exposure in adults—systematic review and meta-analysis J. Radiat. Res. (IF 2.0) Pub Date : 2023-10-11 Nafiseh Beygom Mirkatouli, Seiko Hirota, Shinji Yoshinaga
Notably, the growing use of radionuclear technology, especially in diagnostic and therapeutic procedures involving radiation exposure, raises concerns about the health effects of radiation. Although epidemiological studies have provided strong evidence for elevated thyroid cancer risk after radiation exposure in childhood, the risk of thyroid cancer associated with adult exposure remains to be investigated
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Radiation-induced gastric injury during radiotherapy: molecular mechanisms and clinical treatment J. Radiat. Res. (IF 2.0) Pub Date : 2023-10-03 Guangxia Chen, Zuxiang Yu, Yuehua Zhang, Shiyu Liu, Chong Chen, Shuyu Zhang
Radiotherapy (RT) has been the standard of care for treating a multitude of cancer types. Radiation-induced gastric injury (RIGI) is a common complication of RT for thoracic and abdominal tumors. It manifests acutely as radiation gastritis or gastric ulcers, and chronically as chronic atrophic gastritis or intestinal metaplasia. In recent years, studies have shown that intracellular signals such as
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Acute hematologic toxicity of radiation therapy - a comprehensive analysis and predictive nomogram. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Kazuya Takeda,Rei Umezawa,Takaya Yamamoto,Noriyoshi Takahashi,Yu Suzuki,Keita Kishida,So Omata,Keiichi Jingu
To investigate radiation-induced cytopenia and establish predictive nomograms for hematological toxicity, we reviewed 3786 patients aged 18 or older who received radiation monotherapy between 2010 and 2021 for non-hematologic malignancies. We collected data on patient background, treatment content and hematologic toxicities for 12 weeks after the start of radiotherapy. The patients were randomly divided
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Radiation-quality-dependent bystander cellular effects induced by heavy-ion microbeams through different pathways. J. Radiat. Res. (IF 2.0) Pub Date : 2023-09-22 Masao Suzuki,Tomo Funayama,Michiyo Suzuki,Yasuhiko Kobayashi
We investigated the radiation-quality-dependent bystander cellular effects using heavy-ion microbeams with different ion species. The heavy-ion microbeams were produced in Takasaki Ion Accelerators for Advanced Radiation Application, National Institutes for Quantum Science and Technology. Carbon (12C5+, 220 MeV), neon (20Ne7+, 260 MeV) and argon (40Ar13+, 460 MeV) ions were used as the microbeams,
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Planning strategies for robust carbon-ion scanning radiotherapy for stage I esophageal cancer: a retrospective study. J. Radiat. Res. (IF 2.0) Pub Date : 2023-09-22 Makito Suga,Yohsuke Kusano,Yosuke Takakusagi,Yukio Oosawa,Shinichi Minohara,Daisaku Yoshida,Hiroyuki Katoh,Tadashi Kamada,Masataka Komori
This study aimed to establish a treatment planning strategy with carbon-ion scanning radiotherapy (CIRTs) for stage I esophageal cancer. The clinical data of seven patients treated with CIRTs were used. The setup error and interfractional and intrafractional motion error were analyzed using in-room computed tomography (CT) images for each treatment day. Finally, the planning target volume (PTV) margin
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Definitive carbon ion re-irradiation with pencil beam scanning in the treatment of unresectable locally recurrent rectal cancer. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Xin Cai,Ping Li,Jingfang Zhao,Weiwei Wang,Jingyi Cheng,Guangyuan Zhang,Sanjun Cai,Zhen Zhang,Guoliang Jiang,Qing Zhang,Zheng Wang
This study aimed to evaluate the oncological outcomes and safety of carbon ion re-irradiation with pencil beam scanning (PBS) delivery technique for previously irradiated and unresectable locally recurrent rectal cancer (LRRC). Between June 2017 and September 2021, 24 patients of unresectable LRRC with prior pelvic photon radiotherapy who underwent carbon ion re-irradiation at our institute were retrospectively
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A JROD survey: nationwide overview of radiotherapy data from 2015 to 2021. J. Radiat. Res. (IF 2.0) Pub Date : 2023-11-21 Hisateru Ohba,Yoshihiro Nakada,Hodaka Numasaki,Kensuke Umehara,Junko Ota,Yasuo Okuda,Teruki Teshima,Kazuhiko Ogawa,Katsumasa Nakamura,Japanese Society For Radiation Oncology Database Committee
The purpose of this survey was to examine the status of radiotherapy in Japan based on the cases registered in the Japanese Radiation Oncology Database (JROD), from 2015 to 2021, and to provide basic data to help improve the usefulness of the JROD in the future. The study population consisted of patients who underwent radiotherapy between 2014 and 2020 and did not opt out of the study. The survey item
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Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy J. Radiat. Res. (IF 2.0) Pub Date : 2023-09-17 Yoshihide Hattori, Tooru Andoh, Shinji Kawabata, Naonori Hu, Hiroyuki Michiue, Hiroyuki Nakamura, Takahiro Nomoto, Minoru Suzuki, Takushi Takata, Hiroki Tanaka, Tsubasa Watanabe, Koji Ono
Recently, boron neutron capture therapy (BNCT) has been attracting attention as a minimally invasive cancer treatment. In 2020, the accelerator-based BNCT with L-BPA (Borofalan) as its D-sorbitol complex (Steboronine®) for head and neck cancers was approved by Pharmaceutical and Medical Devices Agency for the first time in the world. As accelerator-based neutron generation techniques are being developed
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Long-term outcomes of whole-pelvis radiation therapy using volumetric modulated arc therapy for high-risk prostate cancer J. Radiat. Res. (IF 2.0) Pub Date : 2023-08-29 Reiko Takemura, Kentaro Ishii, Yukinari Hosokawa, Hideyuki Morimoto, Shogo Matsuda, Ryo Ogino, Keiko Shibuya
This study investigated the outcomes of whole-pelvis radiation therapy (WPRT) using volumetric modulated arc therapy (VMAT) for high-risk prostate cancer. We retrospectively analysed 112 patients with high-risk prostate cancer who started WPRT at our hospital between August 2011 and August 2015. The prescribed dose was 78 Gy in 39 fractions to the prostate and 46.8 Gy in 26 fractions to the pelvic
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Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study J. Radiat. Res. (IF 2.0) Pub Date : 2023-08-22 Naonori Hu, Minoru Suzuki, Shin-ichiro Masunaga, Genro Kashino, Yuko Kinashi, Yi-Wen Chen, Yong Liu, Koki Uehara, Toshinori Mitsumoto, Hiroki Tanaka, Koji Ono
A neutron beam for boron neutron capture therapy (BNCT) of deep-seated tumours is designed to maintain a high flux of epithermal neutrons, while keeping the thermal and fast neutron component as low as possible. These neutrons (thermal and fast) have a high relative biological effectiveness in comparison with high energy photon beams used for conventional X-ray radiotherapy. In the past, neutrons for
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Evaluation of deep learning-based deliverable VMAT plan generated by prototype software for automated planning for prostate cancer patients J. Radiat. Res. (IF 2.0) Pub Date : 2023-08-22 Noriyuki Kadoya, Yuto Kimura, Ryota Tozuka, Shohei Tanaka, Kazuhiro Arai, Yoshiyuki Katsuta, Hidetoshi Shimizu, Yuto Sugai, Takaya Yamamoto, Rei Umezawa, Keiichi Jingu
This study aims to evaluate the dosimetric accuracy of a deep learning (DL)-based deliverable volumetric arc radiation therapy (VMAT) plan generated using DL-based automated planning assistant system (AIVOT, prototype version) for patients with prostate cancer. The VMAT data (cliDose) of 68 patients with prostate cancer treated with VMAT treatment (70–74 Gy/28–37 fr) at our hospital were used (n =
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Increased radiosensitivity of melanoma cells through cold plasma pretreatment mediated by ICG J. Radiat. Res. (IF 2.0) Pub Date : 2023-08-17 Sara Momeni, Ahmad Shanei, Ameneh Sazgarnia, Rasool Azmoonfar, Farzaneh Ghorbani
Radiation therapy (RT) is the primary treatment for many cancers, but its effectiveness is reduced due to radioresistance and side effects. The study aims to investigate an emerging treatment for cancer, cold atmospheric plasma (CAP), as a selectable treatment between cancerous and healthy cells and its role in the occurrence of photodynamic therapy (PDT) utilizing indocyanine green (ICG) as a photosensitizer
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Internal organ dose rate conversion coefficients of Japanese macaques to 134Cs,137Cs and 131I J. Radiat. Res. (IF 2.0) Pub Date : 2023-08-08 Yuta Takamura, Tsuyoshi Kajimoto, Kenichi Tanaka, Tomoya Yamamoto, Masatoshi Suzuki, Yohei Inaba, Koichi Chida, Manabu Fukumoto, Chary Rangacharyulu, Satoru Endo
The purpose of this study was to estimate the internal dose of radiation in Japanese macaques (aka Nihonzaru or snow monkey) due to the Fukushima nuclear power plant accident. Images of a male Japanese macaque weighing ~10 kg were acquired using a multi-slice computed tomography (CT) scan with a 64-row segment detector. The CT images were used to create voxel phantoms of the bones, bone marrow, brain
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The effects of BPA-BNCT on normal bone: determination of the CBE value in mice J. Radiat. Res. (IF 2.0) Pub Date : 2023-07-30 Ryota Iwasaki, Ryutaro Yoshikawa, Ryo Umeno, Azusa Seki, Takehisa Matsukawa, Satoshi Takeno, Kazuhito Yokoyama, Takashi Mori, Minoru Suzuki, Koji Ono
Boron neutron capture therapy (BNCT) with p-boronophenylalanine (BPA) is expected to have less effect on the decrease in normal bone strength than X-ray therapy. However, the compound biological effectiveness (CBE) value necessary to convert the boron neutron capture reaction (BNCR) dose into a bioequivalent X-ray dose has not been determined yet. The purpose of this study was to evaluate the influence
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Development of a prediction model for head and neck volume reduction by clinical factors, dose–volume histogram parameters and radiomics in head and neck cancer J. Radiat. Res. (IF 2.0) Pub Date : 2023-07-19 Miyu Ishizawa, Shohei Tanaka, Hisamichi Takagi, Noriyuki Kadoya, Kiyokazu Sato, Rei Umezawa, Keiichi Jingu, Ken Takeda
In external radiotherapy of head and neck (HN) cancers, the reduction of irradiation accuracy due to HN volume reduction often causes a problem. Adaptive radiotherapy (ART) can effectively solve this problem; however, its application to all cases is impractical because of cost and time. Therefore, finding priority cases is essential. This study aimed to predict patients with HN cancers are more likely
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Expression of TMEM59L associated with radiosensitive in glioblastoma. J. Radiat. Res. (IF 2.0) Pub Date : 2023-09-22 Dezhi Gao,Peng Wang,Lin Zhi,Shibin Sun,Xiaoguang Qiu,Yanwei Liu
Radiotherapy is one of the cornerstone of the glioblastoma treatment paradigm. However, the resistance of tumor cells to radiation results in poor survival. The mechanism of radioresistance has not been fully elucidated. This study aimed to screen the differential expressed genes related with radiosensitivity. The differentially expressed genes were screened based on RNA sequencing in 15 pairs of primary
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Confounding factors and biases involved in regional differences in the detection rate of thyroid cancer in the second-round Thyroid Ultrasound Examination: the Fukushima Health Management Survey J. Radiat. Res. (IF 2.0) Pub Date : 2023-07-11 Hiroki Shimura, Susumu Yokoya, Satoru Suzuki, Manabu Iwadate, Satoshi Suzuki, Takashi Matsuzuka, Shinichi Suzuki, Fumikazu Hayashi, Masanori Nagao, Tetsuya Ohira, Seiji Yasumura, Hitoshi Ohto, Kenji Kamiya
In response to concerns about health due to radiation exposure, the Fukushima Prefecture launched the Thyroid Ultrasound Examination program for residents aged 0–18 years at the time of the earthquake. Herein, we considered the confounding factors involved in the regional differences in the development of thyroid cancer. In this study, the 242 065 individuals who participated in both first- and second-round
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Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy J. Radiat. Res. (IF 2.0) Pub Date : 2023-07-11 Lin Deng, Shaoqing Wang, Xingli Leng, Peng Yao, Cuicui Li, Yang Zheng
Radiation nephropathy refers to kidney damage caused by radiation therapy for malignant tumours. Currently, the pathogenesis is unclear and there is a lack of effective treatment methods. With the development of traditional Chinese medicine, the role of traditional Chinese medicine in the protection of radiation nephropathy is receiving increasing attention. Therefore, in this study, we used X-ray
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Partial liver irradiation in rats induces the hypertrophy of nonirradiated liver lobes through hepatocyte proliferation J. Radiat. Res. (IF 2.0) Pub Date : 2023-07-10 Takuya Adachi, Yukari Yoshida, Kei Shibuya, Ken Sato, Yuichi Yamazaki, Satoru Kakizaki, Toshio Uraoka, Akihisa Takahashi
Irradiation of the liver induces a regenerative response in the nonirradiated part of the liver. It is unclear whether this leads to actual liver enlargement. The aim of this study was to evaluate the weight of compensatory hypertrophy that occurs in nonirradiated livers and to clarify the mechanism of hypertrophy from the viewpoint of hepatocyte proliferation. The anterior liver lobes (anterior lobes)
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Event-by-event approach to the oxygen-effect-incorporated stochastic microdosimetric kinetic model for hypofractionated multi-ion therapy J. Radiat. Res. (IF 2.0) Pub Date : 2023-07-08 Taku Inaniwa, Nobuyuki Kanematsu
An oxygen-effect-incorporated stochastic microdosimetric kinetic (OSMK) model was previously developed to estimate the survival fraction of cells exposed to charged-particle beams with wide dose and linear energy transfer (LET) ranges under various oxygen conditions. In the model, hypoxia-induced radioresistance was formulated based on the dose-averaged radiation quality. This approximation may cause
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Assessing target localization accuracy across different soft-tissue matching protocols using end-exhalation breath-hold cone-beam computed tomography in patients with pancreatic cancer J. Radiat. Res. (IF 2.0) Pub Date : 2023-06-20 Makoto Sasaki, Mitsuhiro Nakamura, Ryo Ashida, Manabu Nakata, Michio Yoshimura, Takashi Mizowaki
The purpose of this study was to retrospectively assess target localization accuracy across different soft-tissue matching protocols using cone-beam computed tomography (CBCT) in a large sample of patients with pancreatic cancer and to estimate the optimal margin size for each protocol. Fifty-four consecutive patients with pancreatic cancer who underwent 15-fraction volumetric modulated arc therapy
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The effects of cystine and theanine mixture on the chronic survival rate and tumor incidence of rats after total body X-ray irradiation J. Radiat. Res. (IF 2.0) Pub Date : 2023-06-20 Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Takashi Tsuchiya, Masahiro Nakashima
Cystine and theanine (CT), an amino acid mixture, provides the substrates cysteine and glutamic acid that promote glutathione synthesis. We previously reported that CT pre-treatment significantly improved the acute survival rate and reduced acute radiation injury of the small intestine and bone marrow of rats after 5 Gy of total body X-ray irradiation. To examine the long-term effects of CT administration