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Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival Radiol. Oncol. (IF 2.4) Pub Date : 2024-03-07 Yueyi Xing, Xue Jing, Gong Qing, Yueping Jiang
Background The high mortality rate of pancreatic ductal adenocarcinoma (PDAC) is primarily attributed to metastasis. Laminin subunit alpha 3 (LAMA3) is known to modulate tumor progression. However, the influence of LAMA3 on liver metastasis in PDAC remains unclear. This study aimed to elucidate whether LAMA3 expression is increased in PDAC with liver metastasis. Patients and methods We extracted information
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The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism Radiol. Oncol. (IF 2.4) Pub Date : 2024-03-07 Xiaohui Wang, Feng Wang, Pengfei Dong, Lin Zhou
Background The aim of the study was to explore the therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its related mechanism. Materials and methods The Span-PEG microbubbles loaded with schisandrin A were prepared using Span60, NaCl, PEG-1500, and schisandrin A. The loading rate of schisandrin A in Span-PEG composite microbubbles was determined
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Dosimetry and efficiency comparison of knowledge-based and manual planning using volumetric modulated arc therapy for craniospinal irradiation Radiol. Oncol. (IF 2.4) Pub Date : 2024-03-07 Wei-Ta Tsai, Hui-Ling Hsieh, Shih-Kai Hung, Chi-Fu Zeng, Ming-Fen Lee, Po-Hao Lin, Chia-Yi Lin, Wei-Chih Li, Wen-Yen Chiou, Tung-Hsin Wu
Background Craniospinal irradiation (CSI) poses a challenge to treatment planning due to the large target, field junction, and multiple organs at risk (OARs) involved. The aim of this study was to evaluate the performance of knowledge-based planning (KBP) in CSI by comparing original manual plans (MP), KBP RapidPlan initial plans (RPI), and KBP RapidPlan final plans (RPF), which received further re-optimization
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Impact of early integrated rehabilitation on fatigue in 600 patients with breast cancer – a prospective study Radiol. Oncol. (IF 2.4) Pub Date : 2024-03-07 Masa Auprih, Tina Zagar, Nina Kovacevic, Andreja Cirila Skufca Smrdel, Nikola Besic, Vesna Homar
Background Fatigue after breast cancer treatment is a common burden that is challenging to treat. The aim of this study was to explore if such integrated rehabilitation program reduces the prevalence of chronic fatigue compared to simple, non-integrated rehabilitation. Patients and methods The subjects of our prospective study were 600 female breast cancer patients (29–65 [mean 52 years] of age), who
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Influence of different intraoperative fluid management on postoperative outcome after abdominal tumours resection Radiol. Oncol. (IF 2.4) Pub Date : 2024-03-07 Matej Jenko, Katarina Mencin, Vesna Novak-Jankovic, Alenka Spindler-Vesel
Background Intraoperative fluid management is a crucial aspect of cancer surgery, including colorectal surgery and pancreatoduodenectomy. The study tests if intraoperative multimodal monitoring reduces postoperative morbidity and duration of hospitalisation in patients undergoing major abdominal surgery treated by the same anaesthetic protocols with epidural analgesia. Patients and methods A prospective
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Looking through the imaging perspective: the importance of imaging necrosis in glioma diagnosis and prognostic prediction – single centre experience Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Hui Ma, Shanmei Zeng, Dingxiang Xie, Wenting Zeng, Yingqian Huang, Liwei Mazu, Nengjin Zhu, Zhiyun Yang, Jianping Chu, Jing Zhao
Background The aim of the study was to investigate the diagnostic value of imaging necrosis (Imnecrosis) in grading, predict the genotype and prognosis of gliomas, and further assess tumor necrosis by dynamic contrast-enhanced MR perfusion imaging (DCE-MRI). Patients and methods We retrospectively included 150 patients (104 males, mean age: 46 years old) pathologically proved as adult diffuse gliomas
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Sarcopenic obesity in cancer Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Mihaela Jurdana, Maja Cemazar
Background Sarcopenic obesity is a relatively new term. It is a clinical condition characterized by sarcopenia (loss of muscle mass and function) and obesity (increase in fat mass) that mainly affects older adults. As the incidence of sarcopenia and obesity increases worldwide, sarcopenic obesity is becoming a greater problem also in cancer patients. In fact, sarcopenic obesity is associated with poorer
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The prognostic significance of programmed cell death protein 1 and its ligand on lymphoma cells and tumor-immune cells in diffuse large B-cell lymphoma, not otherwise specified Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Teja Cas Slak, Simona Miceska, Gorana Gasljevic, Lucka Boltezar, Veronika Kloboves-Prevodnik
Background Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) is the most common type non-Hodgkin’s lymphoma, where the treatment of relapsed/refractory cases is the major challenge. Programmed cell death protein 1 (PD-1) and its ligand PD-L1 play a crucial role in the negative regulation of the immune response against the disease. The aim of the study was to analyze the expression
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Role of endoscopic ultrasound-guided fine needle aspiration biopsies in diagnosing pancreatic neoplasms in the paediatric population: experience from a tertiary center and review of the literature Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Maja Kebe Radulovic, Jernej Brecelj, Andrej Gruden, Margareta Strojan Flezar
Background Endoscopic ultrasound-guided fine needle aspiration biopsy (EUS FNAB) is a well established diagnostic method in adult patients, but is rarely used in the paediatric population. The Clinical Department of Gastroenterology at the University Clinical Centre Ljubljana and the Department of Cytopathology at the Institute of Pathology, Faculty of Medicine, University of Ljubljana, Slovenia, have
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The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Maria Scuderi, Janja Dermol-Cerne, Janez Scancar, Stefan Markovic, Lea Rems, Damijan Miklavcic
Background Electrochemotherapy (ECT) is a treatment involving the administration of chemotherapeutics drugs followed by the application of 8 square monopolar pulses of 100 μs duration at a repetition frequency of 1 Hz or 5000 Hz. However, there is increasing interest in using alternative types of pulses for ECT. The use of high-frequency short bipolar pulses has been shown to mitigate pain and muscle
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Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Manuel Ramanovic, Marko Novak, Andraz Perhavec, Taja Jordan, Karteek Popuri, Nada Rotovnik Kozjek
Background Retroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We investigated the impact of body composition on outcome in patients operated on for primary localized RPS. Patients and methods We retrospectively analysed data for all patients operated on for primary RPS at our institution between 1999 and 2020. Preoperative
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The influence of cytotoxic drugs on the immunophenotype of blast cells in paediatric B precursor acute lymphoblastic leukaemia Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Tomaz Prelog, Simon Bucek, Andreja Brozic, Jakob Peterlin, Marko Kavcic, Masa Omerzel, Bostjan Markelc, Tanja Jesenko, Veronika Kloboves Prevodnik
Background Flow cytometry plays is important in the diagnosis of acute lymphoblastic leukaemia (ALL) and when antigen-specific immunotherapy is indicated. We have investigated the effects of prednisolone, vincristine, daunorubicin, asparaginase and methotrexate on the antigen expression on blast cells that could influence the planning of antigen-specific therapy as well as risk-based treatment assignment
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The influence of anaesthesia on cancer growth Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Iztok Potocnik, Milena Kerin-Povsic, Jasmina Markovic-Bozic
Background Oncological patients make up a large proportion of all surgical patients. Through its influence on the patient’s inflammatory and immune system, the choice of anaesthetic technique has an indirect impact on the health of the individual patient and on public health. Both the specific and the non-specific immune system have a major influence on the recurrence of carcinomas. The pathophysiological
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Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Ana Mervic, Katja Goricar, Tanja Blagus, Alenka Franko, Katarina Trebusak-Podkrajsek, Metoda Dodic Fikfak, Vita Dolzan, Viljem Kovac
Background Asbestos exposure has been proposed as a risk factor for shorter telomere length. The aim of our study was to investigate whether telomere length in leukocytes and hTERT genetic polymorphisms may serve as potential biomarkers for the risk of developing asbestos-related diseases and as biomarkers of progression and chemotherapy response rate in malignant mesothelioma (MM). Subjects and methods
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RAD54B promotes gastric cancer cell migration and angiogenesis via the Wnt/β-catenin pathway Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Jianchao Li, Hui Geng, Xin Li, Shenshan Zou, Xintao Xu
Background Gastric cancer is an epidemic malignancy that is commonly diagnosed at the late stage. Evidence has elucidated that RAD54B exerts a crucial role in the progress of various tumors, but its specific role and mechanism in gastric cancer remain gloomy. Materials and methods The level of RAD54B was detected by western blot. RAD54B expression was downregulated or upregulated in both MKN45 and
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Role of diffusion-weighted imaging in response prediction and evaluation after high dose rate brachytherapy in patients with colorectal liver metastases Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Salma Karim, Ricarda Seidensticker, Max Seidensticker, Jens Ricke, Regina Schinner, Karla Treitl, Johannes Rübenthaler, Maria Ingenerf, Christine Schmid-Tannwald
Background The aim of the study was to assess the role of diffusion-weighted imaging (DWI) to evaluate treatment response in patients with liver metastases of colorectal cancer. Patients and methods In this retrospective, observational cohort study, we included 19 patients with 18 responding metastases (R-Mets; follow-up at least one year) and 11 non-responding metastases (NR-Mets; local tumor recurrence
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Detection performance and prognostic value of initial bone marrow involvement in diffuse large B-cell lymphoma: a single centre 18F-FDG PET/CT and bone marrow biopsy evaluation study Radiol. Oncol. (IF 2.4) Pub Date : 2024-02-20 Andrej Doma, Katarina Zevnik, Andrej Studen, Veronika Kloboves Prevodnik, Gorana Gasljevic, Barbara Jezersek Novakovic
Background Detection of bone marrow involvement (BMI) in diffuse large B-cell lymphoma (DLBCL) typically relies on invasive bone marrow biopsy (BMB) that faces procedure limitations, while 18F-FDG PET/CT imaging offers a noninvasive alternative. The present study assesses the performance of 18F-FDG PET/CT in DLBCL BMI detection, its agreement with BMB, and the impact of BMI on survival outcomes. Patients
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Quantitative assessment of bone marrow infiltration and characterization of tumor burden using dual-layer spectral CT in patients with multiple myeloma Radiol. Oncol. (IF 2.4) Pub Date : 2024-01-06 Xing Xiong, Rong Hong, Xu Fan, Zhengmei Hao, Xiaohui Zhang, Yu Zhang, Chunhong Hu
Background The aim of the study was to evaluate whether virtual calcium subtraction (VNCa) image extracted from dual-layer spectral CT could estimate bone marrow (BM) infiltration with MRI as the reference standard and characterize tumor burden in patients with multiple myeloma (MM). Patients and methods Forty-seven patients with newly diagnosed MM were retrospectively enrolled. They had undergone
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Multi-institutional study of ‘Sandwich treatment’ for motor area large brain metastases (LBM) with diameter over 3 cm Radiol. Oncol. (IF 2.4) Pub Date : 2024-01-06 Zheng Wang, Haining Chen, Qun Chen, Yucun Zhu, Min Li, Jia Zhou
Background The objective of the present study was to explore the effectiveness and safety of ‘Sandwich treatment’ strategy for large brain metastases (LBM) with diameter over 3 cm (minimum volume >= 15 cm3) located in motor area. Patients and methods Patients from four gamma knife center that received ‘Sandwich treatment’ were retrospectively studied from January 2016 to March 2023. The strategy was
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A retrospective study on improving the accuracy of radiotherapy for patients with breast cancer with lymph node metastasis using Styrofoam Radiol. Oncol. (IF 2.4) Pub Date : 2024-01-06 Jie Li, Lin Yang, Xiaowei Yao, Linlin Xu, Lina Zhao, Fei Bai
Background To retrospectively analyze the accuracy of radiotherapy using cone beam computed tomography (CBCT), Styrofoam fixation, and breast bracket fixation in the chest wall target area and supraclavicular lymphatic drainage area (supraclavicular target area) of patients with breast cancer.and compare the setting efficiency and comfort satisfaction. Patients and methods A total of 65 patients with
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Assessment of short-term effect of platelet-rich plasma treatment of tendinosis using texture analysis of ultrasound images Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Karlo Pintaric, Vladka Salapura, Ziga Snoj, Andrej Vovk, Mojca Bozic Mijovski, Jernej Vidmar
Background Computer-aided diagnosis (i.e., texture analyses) tools are becoming increasingly beneficial methods to monitor subtle tissue changes. The aim of this pilot study was to investigate short-term effect of platelet rich plasma (PRP) treatment in supraspinatus and common extensor of the forearm tendinosis by using texture analysis of ultrasound (US) images as well as by clinical questionnaires
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Apparent diffusion coefficient measurements of bone marrow infiltration patterns in multiple myeloma for the assessment of tumor burden – a feasibility study Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Xing Xiong, Yuzhu Ma, Yao Dai, Chunhong Hu, Yu Zhang
Background The purpose of our study was to explore and compare the tumor burden of different bone marrow infiltration patterns and evaluate the feasibility of apparent diffusion coefficient (ADC) value to identify patterns in multiple myeloma (MM). Patients and methods Ninety-three patients with newly diagnosed multiple myeloma and 23 controls had undergone routine magnetic resonance imaging (MRI)
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The association of genetic factors with serum calretinin levels in asbestos-related diseases Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Cita Zupanc, Alenka Franko, Danijela Strbac, Viljem Kovac, Vita Dolzan, Katja Goricar
Background Asbestos exposure is associated with different asbestos-related diseases, including malignant mesothelioma (MM). MM diagnosis is confirmed with immunohistochemical analysis of several markers, including calretinin. Increased circulating calretinin was also observed in MM. The aim of the study was to determine if CALB2 polymorphisms or polymorphisms in genes that can regulate calretinin expression
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Dosimetric comparison of postoperative interstitial high-dose-rate brachytherapy and modern external beam radiotherapy modalities in tongue and floor of the mouth tumours in terms of doses to critical organs Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Örs Ferenczi, Tibor Major, Georgina Fröhlich, Dalma Béla, Szabolcs Tódor, Csaba Polgár, Hironori Akiyama, Botond Bukovszky, Zoltán Takácsi-Nagy
Background The aim of the study was to dosimetrically compare interstitial high-dose-rate (HDR) brachytherapy (BT) and modern external beam radiotherapy modalities, as volumetric modulated arc therapy (VMAT) and stereotactic radiotherapy with Cyberknife (CK) of tumours of the tongue and floor of the mouth in terms of dose to the critical organs. Patients and methods In National Institute of Oncology
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Phase angle as a prognostic indicator of surgical outcomes in patients with gastrointestinal cancer Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Jana Gulin, Ester Ipavic, Denis Mlakar Mastnak, Erik Brecelj, Ibrahim Edhemovic, Nada Rotovnik Kozjek
Background In patients with gastrointestinal cancer with planned elective surgery, malnutrition increases the risk of adverse outcomes in the postoperative period. The phase angle, measured by the bioelectrical impedance analysis is an indicator of the metabolic and functional status of the patient. It may be an important prognostic indicator for the clinical outcome of post-surgical treatment in patients
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Quantitative SSTR-PET/CT for predicting response and survival outcomes in patients with pancreatic neuroendocrine tumors receiving CAPTEM Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Maria Ingenerf, Homeira Karim, Christoph Auernhammer, Matthias Zacherl, Vera Wenter, Michael Winkelmann, Jens Ricke, Frank Berger, Christine Schmid-Tannwald
Background This study aimed to evaluate the predictive and monitoring role of somatostatin receptor (SSTR) positron emission tomography-computed tomography (PET/CT) and clinical parameters in patients with neuroendocrine liver metastases (NELM) from pancreatic neuroendocrine tumors (pNET) receiving capecitabine and temozolomide (CAPTEM). Patients and methods This retrospective study included twenty-two
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Correlation between maximum heart distance and thoracic diameter changes and diaphragmatic descent in left-sided breast cancer patients during deep inspiration breath-hold (DIBH) Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 He-Gou Wu, Guang-Wei Zhang, Jian-Feng Liu, Jun-Guo Yang, Xiao-Hui Su
Background Cardioprotection is valued in radiotherapy for patients with left-sided breast cancer. Deep inspiration breath-hold (DIBH) technique can achieve cardioprotection well. However, during DIBH, the extent to which the heart enters the radiation field is affected by the movement of the thorax and diaphragm. The aim of this study was to analyze the correlation between the maximum distance of the
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Imaging microvascular changes in nonocular oncological clinical applications by optical coherence tomography angiography: a literature review Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Rok Hren, Gregor Sersa, Urban Simoncic, Matija Milanic
Background Optical coherence tomography angiography (OCTA) is an emerging imaging modality that enables noninvasive visualization and analysis of tumor vasculature. OCTA has been particularly useful in clinical ocular oncology, while in this article, we evaluated OCTA in assessing microvascular changes in clinical nonocular oncology through a systematic review of the literature. Method The inclusion
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Retropharyngeal calcific tendinitis in the neurological emergency unit, report of three cases and review of the literature Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Tatjana Filipovic, Jernej Avsenik
Background Retropharyngeal calcific tendinitis (RCT) is a relatively benign condition of calcination of the longus colli muscle tendon of unknown origin, which causes severe acute neck pain. However, it is often not recognised, which leads to delayed diagnosis and unnecessary treatment. Patients and methods We have searched PubMed and Google Scholar for publications which reported at least one patient
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The prognostic significance of tumor-immune microenvironment in ascites of patients with high-grade serous carcinoma Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Simona Miceska, Erik Skof, Simon Bucek, Cvetka Grasic Kuhar, Gorana Gasljevic, Spela Smrkolj, Veronika Kloboves Prevodnik
Background High-grade serous carcinoma (HGSC) is often associated with ascites at presentation. Our objective was to quantify immune cells (ICs) in ascites prior to any treatment was given and evaluate their impact on progression-free survival (PFS) and overall survival (OS). Patients and methods Forty-seven patients with primary HGSC and ascites were included. Flow-cytometric analysis was performed
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Breast-lesion assessment using amide proton transfer-weighted imaging and dynamic contrast-enhanced MR imaging Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Lulu Zhuang, Chun Lian, Zehao Wang, Ximin Zhang, Zhigang Wu, Rong Huang
Background Previous studies have indicated that amide proton transfer-weighted imaging (APTWI) could be utilized for differentiating benign and malignant tumors. The APTWI technology has increasingly being applied to breast tumor research in recent years. However, according to the latest literature retrieval, no relevant previous studies compared the value of APTWI and dynamic contrast-enhanced (DCE)
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Locoregional therapy combined with systemic therapy (LRT + ST) for unresectable and metastatic intrahepatic cholangiocarcinoma: a systematic review and meta-analysis Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Mengqi Zhang, Weiwei Qi, Xiaofei Qiu, Chunpeng Yu, Wensheng Qiu, Song Wang, Zhenkang Qiu
Background The outcome of systemic therapy (ST) for unresectable and metastatic intrahepatic cholangiocarcinoma (iCCA) is poor. This study aims to further evaluate the efficacy and safety of locoregional therapy combined with systemic therapy (LRT + ST) compared with only ST in unresectable and metastatic iCCA by performing a systematic literature review and meta-analysis. Methods A comprehensive search
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Post-radiation xerostomia therapy with allogeneic mesenchymal stromal stem cells in patients with head and neck cancer: study protocol for phase I clinical trial Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Primoz Strojan, Gaber Plavc, Marko Kokalj, Goran Mitrovic, Olga Blatnik, Luka Lezaic, Aljaz Socan, Aljosa Bavec, Natasa Tesic, Katrina Hartman, Urban Svajger
Background Xerostomia is a common side effect of radiotherapy in patients with head and neck tumors that negatively affects quality of life. There is no known effective standard treatment for xerostomia. Here, we present the study protocol used to evaluate the safety and preliminary efficacy of allogeneic mesenchymal stromal stem cells (MSCs) derived from umbilical cord tissue. Patients and methods
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Management of tumor volume changes during preoperative radiotherapy for extremity soft tissue sarcoma: a new strategy of adaptive radiotherapy Radiol. Oncol. (IF 2.4) Pub Date : 2023-12-04 Marion Geneau De Lamarliere, Amélie Lusque, Justine Attal Khalifa, Vincent Esteyrie, Christine Chevreau, Thibaud Valentin, Dimitri Gangloff, Thomas Meresse, Louis Courtot, Philippe Rochaix, Bérénice Boulet, Eliane Graulieres, Anne Ducassou
Background Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan. Patients and methods We included 17 patients with a lower extremity ESTS treated between 2019 and 2021 with preoperative RT, using helicoidal intensity-modulated RT (IMRT) tomotherapy, before
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Prominin 2 decreases cisplatin sensitivity in non-small cell lung cancer and is modulated by CTCC binding factor Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Jiyang Tang, Dejun Shu, Zhimin Fang, Gaolan Yang
Background Non-small cell lung cancer (NSCLC) is the major pathological type of lung cancer and accounts for the majority of lung cancer-related deaths worldwide. We investigated the molecular mechanism of prominin 2 (PROM2) involved in cisplatin resistance in NSCLC. Patients and methods The GEO database was analyzed to obtain differential genes to target PROM2. Immunohistochemistry and western blotting
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Central and peripheral pulmonary sclerosing pneumocytomas: multi-phase CT study and comparison with Ki-67 Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Yanli Zhang, Chao Ran, Wei Li
Background This study aimed to evaluate the multi-phase CT findings of central and peripheral pulmonary sclerosing pneumocytomas (PSPs) and compared them with Ki-67 to reveal their neoplastic nature. Patients and methods Multi-phase CT and clinical data of 33 PSPs (15 central PSPs and 18 peripheral PSPs) were retrospectively analyzed and compared their multi-phase CT features and Ki-67 levels. Results
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Billroth-I anastomosis in distal subtotal gastrectomy for non-early gastric adenocarcinoma Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Sevak S Shahbazyan, Mushegh A Sahakyan, Artak Gabrielyan, Xiaoran Lai, Aram Martirosyan, Hmayak Petrosyan, Shushan Yesayan, Artur M Sahakyan
Background Billroth-I (B-I) anastomosis is known as a simple and physiological reconstruction method after distal subtotal gastrectomy for early gastric cancer. Yet its role and oncological validity in non-early gastric adenocarcinoma (NEGA) remain unclear. Patients and methods Patients with NEGA without distant metastases operated between May 2004 and December 2020 were included. Surgical and oncologic
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Treatment and outcome of patients with Graves’ disease and metastatic differentiated thyroid cancer Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Nikola Besic, Barbara Vidergar-Kralj
Background The aim of the study was to report on the experience in a single tertiary cancer center about the treatment and outcome of patients with Graves’ disease (GD) and metastatic thyroid cancer as compared with patients without GD in our country. Patients and methods Altogether, 28 patients (8 males, 20 females; 49–85 years of age; median 74 years) were treated because of differentiated thyroid
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Erector spinae plane block versus intercostal nerve block for postoperative analgesia in lung cancer surgery Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Polona Gams, Marko Bitenc, Nenad Danojevic, Tomaz Jensterle, Aleksander Sadikov, Vida Groznik, Maja Sostaric
Background A recent trend in postoperative analgesia for lung cancer surgery relies on regional nerve blocks with decreased opioid administration. Our study aims to critically assess the continuous ultrasound-guided erector spinae plane block (ESPB) at our institution and compare it to a standard regional anesthetic technique, the intercostal nerve block (ICNB). Patients and methods A prospective randomized-control
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Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Lidija Ljubicic, Urska Janzic, Mojca Unk, Ana Sophie Terglav, Katja Mohorcic, Fran Seiwerth, Lela Bitar, Sonja Badovinac, Sanja Plestina, Marta Korsic, Suzana Kukulj, Miroslav Samarzija, Marko Jakopovic
Background The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after failing ICI +/− ChT remains an open question, and docetaxel plus nintedanib represent a valid second line option. Patients and methods A multicenter retrospective
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A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Xing Li, Kaida Liu, Lidong Xing, Boris Rubinsky
Background Tumor Treating Fields (TTFields) is a non-invasive modality for cancer treatment that utilizes a specific sinusoidal electric field ranging from 100 kHz to 300 kHz, with an intensity of 1 V/cm to 3 V/cm. Its purpose is to inhibit cancer cell proliferation and induce cell death. Despite promising outcomes from clinical trials, TTFields have received FDA approval for the treatment of glioblastoma
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The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1 -weighted, T2 -weighted and FLAIR images in human brain Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Vida Velej, Ksenija Cankar, Jernej Vidmar
Background Dissolved oxygen has known paramagnetic effects in magnetic resonance imaging (MRI). The aim of this study was to compare the effects of normobaric oxygenation (NBO) and hyperbaric oxygenation (HBO) on human brain MRI signal intensities. Patients and methods Baseline brain MRI was performed in 17 healthy subjects (mean age 27.8 ± 3.2). MRI was repeated after exposure to the NBO and HBO at
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Breast cancer risk assessment and risk distribution in 3,491 Slovenian women invited for screening at the age of 50; a population-based cross-sectional study Radiol. Oncol. (IF 2.4) Pub Date : 2023-09-04 Katja Jarm, Vesna Zadnik, Mojca Birk, Milos Vrhovec, Kristijana Hertl, Zan Klanecek, Andrej Studen, Cveto Sval, Mateja Krajc
Background The evidence shows that risk-based strategy could be implemented to avoid unnecessary harm in mammography screening for breast cancer (BC) using age-only criterium. Our study aimed at identifying the uptake of Slovenian women to the BC risk assessment invitation and assessing the number of screening mammographies in case of risk-based screening. Patients and methods A cross-sectional population-based
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Effectiveness and safety of anlotinib with or without S-1 in the treatment of patients with advanced hepatocellular carcinoma in a Chinese population: a prospective, phase 2 study Radiol. Oncol. (IF 2.4) Pub Date : 2023-07-26 Mafei Kang, Feng Xue, Shengyuan Xu, Jieqiong Shi, Yunyan Mo
Background The aim of the study was to observe the safety and efficacy of anlotinib (ANL) alone or combined with S-1 in the first-line treatment of advanced hepatocellular carcinoma (HCC). Patients and methods Fifty-four patients with untreated advanced HCC who could not be resected were randomly divided into the ANL group (n = 27) and ANL+S-1 group (n = 27). The ANL group was given 10 mg ANL orally
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Comparing the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis Radiol. Oncol. (IF 2.4) Pub Date : 2023-07-26 Longjie Xia, Jianqin Lai, Di Huang, Shenghui Qiu, Huiqiong Hu, Yunxiang Luo, Jie Cao
Background This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [18F]FDG PET/CT and [18F] FDG PET/MRI in detecting bone metastases in breast cancer patients. Methods An extensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases to identify available publications up to February 2023. Studies were included if they evaluated the diagnostic
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Modern approach to the management of genitourinary syndrome in women with gynecological malignancies Radiol. Oncol. (IF 2.4) Pub Date : 2023-07-26 Nina Kovacevic, Ines Cilensek, Sebastjan Merlo, Barbara Segedin
Background The term genitourinary syndrome of menopause was first used in 2014 by the North American Menopause Society and the International Society for the Study of Women's Sexual Health to describe conditions previously known as atrophic vaginitis, urogenital atrophy, or vulvovaginal atrophy. It is a complex, chronic, progressive condition characterized by a wide range of signs and symptoms affecting
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Local control and survival after stereotactic body radiation therapy of early-stage lung cancer patients in Slovenia Radiol. Oncol. (IF 2.4) Pub Date : 2023-07-26 Karmen Stanic, Jasna But-Hadzic, Jan Zagar, Martina Vrankar
Background Stereotactic body radiation therapy (SBRT) precisely and non-invasively delivers ablative radiation dose to tumors in early-stage lung cancer patients who are not candidates for surgery or refuse it. The aim of research was to evaluate local control, overall survival (OS), local progression free survival (LPFS), distant metastases free survival (DMFS), disease free survival (DFS) and toxicity
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Does tumor rupture during robot-assisted partial nephrectomy have an impact on mid-term tumor recurrences? Radiol. Oncol. (IF 2.4) Pub Date : 2023-07-20 Simon Hawlina, Kosta Cerovic, Andraz Kondza, Peter Popovic, Jure Bizjak, Tomaz Smrkolj
Background Intraoperative kidney tumor rupture (TR) can occur during robot-assisted partial nephrectomy (RAPN) in daily clinical practice, but there are no solid guidelines on the management and implications of it. The purpose of the study was to investigate the impact of TR on tumor recurrences, what a surgeon should do if this adverse event occurs, and how to avoid it. Patients and methods We retrospectively
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Monitoring the effect of perioperative nutritional care on body composition and functional status in patients with carcinoma of gastrointestinal and hepatobiliary system and pancreas Radiol. Oncol. (IF 2.4) Pub Date : 2023-07-13 Andrej Gyergyek, Nada Rotovnik Kozjek, Jasna Klen
Background The significance of nutritional care in the management of cancer, particularly in the surgical treatment of abdominal cancer, is increasingly acknowledged. Body composition analysis, such as the Bioelectric impedance assay (BIA), and functional tests, e.g., handgrip strength, are used when assessing nutritional status alongside general and nutritional history, clinical examination, and laboratory
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Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma Radiol. Oncol. (IF 2.4) Pub Date : 2023-07-13 Matej Panjan, Lucka Boltezar, Srdjan Novakovic, Ira Kokovic, Barbara Jezersek Novakovic
Background t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2. Breakpoint most commonly occurs at major breakpoint region (MBR) but may happen at minor cluster region (mcr) and between MBR and mcr at 3′MBR and 5′mcr
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Association between PIK3CA activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Domen Ribnikar, Valentina Jeric Horvat, Ivica Ratosa, Zachary W Veitch, Biljana Grcar Kuzmanov, Srdjan Novakovic, Erik Langerholc, Eitan Amir, Bostjan Seruga
Background The aim of the study was to evaluate the independent prognostic role of PIK3CA activating mutations and an association between PIK3CA activating mutations and efficacy of adjuvant endocrine therapy (ET) in patients with operable invasive lobular carcinoma (ILC). Patients and methods A single institution study of patients with early-stage ILC treated between 2003 and 2008 was performed. Clinicopathological
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Changes in the quality of life of early breast cancer patients and comparison with the normative Slovenian population Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Cvetka Grasic Kuhar, Tjasa Gortnar Cepeda, Christian Kurzeder, Marcus Vetter
Background We aimed to identify changes in quality of life after breast cancer treatment and compare them with the normative population data for the Slovenian population. Patients and methods A prospective, single-group, cohort design was used. A total of 102 early breast cancer patients treated with chemotherapy at the Institute of Oncology Ljubljana were included. Of those, 71% returned the questionnaires
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Cognitive functioning in a cohort of high-grade glioma patients Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Andreja Cirila Skufca Smrdel, Anja Podlesek, Marija Skoblar Vidmar, Jana Markovic, Jana Jereb, Manja Kuzma Okorn, Uros Smrdel
Background High grade gliomas are associated with cognitive problems. The aim of the study was to investigate cognitive functioning in a cohort of patients with high grade glioma, according to isocitrate dehydrogenase (IDH) and methyl guanine methyl transferase (MGMT) status and other clinical characteristics. Patients and methods The patients with the high-grade glioma treated in Slovenia in given
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Two-stage hepatectomy in resection of colorectal liver metastases – a single-institution experience with case-control matching and review of the literature Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Spela Turk, Irena Plahuta, Tomislav Magdalenic, Tajda Spanring, Kevin Laufer, Zan Mavc, Stojan Potrc, Arpad Ivanecz
Background Two-stage hepatectomy (TSH) has been proposed for patients with bilateral liver tumours who have a high risk of posthepatectomy liver failure after one-stage hepatectomy (OSH). This study aimed to determine the outcomes of TSH for extensive bilateral colorectal liver metastases. Patients and methods A retrospective review of a prospectively maintained database of liver resections for colorectal
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Radiological assessment of skeletal muscle index and myosteatosis and their impact postoperative outcomes after liver transplantation Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Miha Petric, Taja Jordan, Popuri Karteek, Sabina Licen, Blaz Trotovsek, Ales Tomazic
Background Liver transplantation offers curative treatment to patients with acute and chronic end-stage liver disease. The impact of nutritional status on postoperative outcomes after liver transplantation remains poorly understood. The present study investigated the predictive value of radiologically assessed skeletal muscle index (SMI) and myosteatosis (MI) on postoperative outcomes. Patients and
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Quantitative dynamic contrast-enhanced parameters and intravoxel incoherent motion facilitate the prediction of TP53 status and risk stratification of early-stage endometrial carcinoma Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Hongxia Wang, Ruifang Yan, Zhong Li, Beiran Wang, Xingxing Jin, Zhenfang Guo, Wangyi Liu, Meng Zhang, Kaiyu Wang, Jinxia Guo, Dongming Han
Background The aim of the study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and intravoxel incoherent motion (IVIM) in differentiating TP53-mutant from wild type, low-risk from non-low-risk early-stage endometrial carcinoma (EC). Patients and methods A total of 74 EC patients underwent pelvic MRI. Parameters volume transfer constant (Ktrans), rate
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Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Tobian Muir, Giulia Bertino, Ales Groselj, Lakshmi Ratnam, Erika Kis, Joy Odili, Ian McCafferty, Walter A Wohlgemuth, Maja Cemazar, Aljosa Krt, Masa Bosnjak, Alessandro Zanasi, Michela Battista, Francesca de Terlizzi, Luca G Campana, Gregor Sersa
Background Biomedical applications of electroporation are expanding out of the field of oncology into vaccination, treatment of arrhythmias and now in the treatment of vascular malformations. Bleomycin is a widely used sclerosing agent in the treatment of various vascular malformations. The application of electric pulses in addition to bleomycin enhances the effectiveness of the drug, as demonstrated
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Correlation of mean apparent diffusion coefficient (ADC) and maximal standard uptake value (SUVmax) evaluated by diffusion-weighted MRI and 18F-FDG-PET/CT in children with Hodgkin lymphoma: a feasibility study Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Nicolas Rosbach, Sebastian Fischer, Vitali Koch, Thomas J. Vogl, Konrad Bochennek, Thomas Lehrnbecher, Scherwin Mahmoudi, Leon Grünewald, Frank Grünwald, Simon Bernatz
Background The objective was to analyse if magnetic resonance imaging (MRI) can act as a non-radiation exposure surrogate for (18)F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in children with histologically confirmed Hodgkin lymphoma (HL) before treatment. This was done by analysing a potential correlation between apparent diffusion coefficient (ADC) in MRI and
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ADC values as a biomarker of fetal brain maturation Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Lucija Kobal, Katarina Surlan Popovic, Jernej Avsenik, Tina Vipotnik Vesnaver
Background During the period of fetal development, myelination plays a key role and follows specific time and spatial sequences. The water content in the brain is inversely proportional to myelination – the more myelinated the brain, the lower the water content in it. The diffusion of water molecules can be quantitatively assessed using the apparent diffusion coefficient (ADC). We were interested in
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Longitudinal monitoring of Apparent Diffusion Coefficient (ADC) in patients with prostate cancer undergoing MR-guided radiotherapy on an MR-Linac at 1.5 T: a prospective feasibility study Radiol. Oncol. (IF 2.4) Pub Date : 2023-06-21 Haidara Almansour, Fritz Schick, Marcel Nachbar, Saif Afat, Victor Fritz, Daniela Thorwarth, Daniel Zips, Felix Bertram, Arndt-Christian Müller, Konstantin Nikolaou, Ahmed E Othman, Daniel Wegener
Background Hybrid MRI linear accelerators (MR-Linac) might enable individualized online adaptation of radiotherapy using quantitative MRI sequences as diffusion-weighted imaging (DWI). The purpose of this study was to investigate the dynamics of lesion apparent diffusion coefficient (ADC) in patients with prostate cancer undergoing MR-guided radiation therapy (MRgRT) on a 1.5T MR-Linac. The ADC values