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High serum total vitamin B12 may mask biologically active B12 deficiency Ann. Clin. Biochem. (IF 2.2) Pub Date : 2024-02-26 Nathan Lorde, Jayne Parkes, Harminder Sensi, Ross Valentine, Morven Baker, Clare Ford, Tejas Kalaria, Rousseau Gama
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Acceptability of plasma ammonia results when samples are not transported and processed under ideal conditions Ann. Clin. Biochem. (IF 2.2) Pub Date : 2024-02-01 Ann Bowron, Victoria Osgood
BackgroundIt is recommended that samples for plasma ammonia analysis are kept chilled and processed promptly as in vitro metabolism causes falsely elevated results. Rejection of unsuitable samples can cause delayed diagnosis and treatment of hyperammonaemia with potentially serious clinical consequences. The Metabolic Biochemistry Network (MetBioNet) hyperammonaemia guideline recommends analysis of
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Detecting thyrotropin receptor mRNA from peripheral blood of patients with differentiated thyroid cancer rules out non-aggressive cases Ann. Clin. Biochem. (IF 2.2) Pub Date : 2024-01-10 Jelena R Janković Miljuš, Uršula Prosenc Zmrzljak, Rok Košir, Milan Jovanović, Ilona Đ Đorić, Jelena V Rončević, Tijana M Išić Denčić, Sonja A Šelemetjev
BackgroundEarly diagnosis of thyroid cancer is hampered by the inability of fine-needle aspiration biopsy (FNAB) to accurately classify ∼30% of cases while preoperative cancer staging detects lymph nodal involvement in only half of cases. Liquid biopsy may present an accurate, non-invasive alternative for preoperative thyroid nodule assessment. Thyrotropin receptor (TSHR) mRNA, a surrogate marker for
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Assay error detection when using common quality control targets across multiple instruments: An analysis using simulated and real-world data Ann. Clin. Biochem. (IF 2.2) Pub Date : 2024-01-04 Eric S Kilpatrick
BackgroundClinical laboratories frequently implement the same tests and internal quality control (QC) rules on identical instruments. It is unclear whether individual QC targets for each analyser or ones that are common to all instruments are preferable. This study modelled how common QC targets influence assay error detection before examining their effect on real-world data.MethodsThe effect of variable
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Case report: Skin protective barrier cream interference in benzethonium chloride method for urine protein measurement in a 6-month-old girl. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-26 Ömer Özcan,Joanna Ae van Wijk,Annet M Bosch,Wendy Pj den Elzen,Annemieke C Heijboer,Johan C Fischer
This case report describes the positive interference of the commonly used skin protective barrier cream used together with urine collection bags on the benzethonium chloride method for urine protein measurements in a 6-month-old female baby, leading to falsely elevated results. The interference was identified by both artificially mixing urine samples with this cream and comparing the results obtained
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Influence of pneumatic tube delivery system on laboratory results. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-24 Rihab Makhlouf,Sana Fendri,Dana Jallouli,Zeinab Labiadh,Lotfi Fritis,Khansa Chaabouni,Aida Elleuch,Fatma Makni Ayadi
INTRODUCTION The pneumatic tube system (PTS) is an automated and fast modality of transportation of biological samples, but it has been reported to induce preanalytical errors. AIM To study the influence of transportation by PTS on biochemistry tests which are particularly sensitive to haemolysis and atmospheric pressure variation. MATERIALS AND METHODS We compared laboratory results of arterial blood
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Implementation of Point-of-Care HbA1C instruments into Community Pharmacies: Initial development of a pathway for robust community testing. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-23 Andrew Radley,Lewis Beer,Danya Rushdi,Hazel Close,Stephen McBurney,Adrian Mackenzie,Anna Gourlay,Anna Barnett,Alison Grant,Neil Greig,Ellie Dow,Calum Sutherland
BACKGROUND Point-of-care (POC) analysers in community settings can provide opportunistic and regular HbA1c monitoring. Community pharmacies in NHS Scotland are utilised by populations at greatest risk of type two diabetes (T2D). This study describes initial development of an HbA1c pathway using a POC analyser in community pharmacies. METHODS The Abbott Afinion analyser was compared in (i) NHS Tayside's
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Reference ranges of thyroid hormones during the first trimester in Catalan women using the Atellica® IM Solution Immunoassay Analyzer. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-23 Marina Giralt,Noelia Díaz-Troyano,Immaculada Comas,Albert Blanco,Laura Conesa,Manel Mendoza,Carles Zafon,María Goya,Roser Ferrer
BACKGROUND Gestational hypothyroidism has been shown to be associated with adverse pregnancy outcomes as well as adverse outcomes for the child. Thyroid hormones concentrations change in gestation, especially within the first trimester, so the results of thyroid function test often are outside non-pregnant reference ranges. The objective of this study was to establish the first trimester reference
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Cardiac troponin in hospitalized COVID-19 patients: Incidence, predictors, and outcomes. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-20 Praveen Gupta,Anunay Gupta,Sandeep Bansal,Ira Balakrishnan
BACKGROUND The incidence, predictors, and association of cardiac troponin with mortality in hospitalized COVID-19 were not adequately studied in the past and were also not reported from an Indian hospital. METHODS In this retrospective cohort study, the cardiac troponin of 240 hospitalized COVID-19 patients was measured. The incidence, predictors, and association of elevated cardiac troponin with in-hospital
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Closed analyser lids do not reduce the measurement uncertainty of serum total carbon dioxide. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-18 Francesca Borrillo,Alessia Capoferri,Leila Rovegno,Mauro Panteghini
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Utilising routine clinical laboratory data to support quality improvement in health care: Application of a national acute kidney injury alert system as a proof of concept. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-18 Jennifer Holmes,Ray Higginson,John Geen,Aled Phillips
BACKGROUND Acute kidney injury (AKI) is a global health issue known to cause avoidable harm and death. Improvement in its prevention and management is therefore considered an important goal for the health-care sector. The work here aimed to develop a tool which could be used to robustly and reliably measure, monitor, and compare the effectiveness of health-care interventions related to AKI across the
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Long term stability of lactate in uncentrifuged sodium fluoride/potassium oxalate blood collection tubes. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-10 Ivan Stevic,Jade Bolsover,Rick Moore,Vipin Bhayana
BACKGROUND Delayed time from collection to centrifugation may cause erroneously high lactate levels in vitro (from continued blood cell metabolism under anaerobic conditions in the collection tube) if not collected in appropriate collection devices, consequently increasing the risk for inappropriate patient care or harm. We undertook a study to determine the turnaround time for lactate testing in a
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Plasma cell-free DNA in patients with acute promyelocytic leukemia treated with arsenic trioxide. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-09 Junko Fujihara,Naoki Nishimoto,Haruo Takeshita
BACKGROUND Cell-free DNA (cfDNA) is free DNA found in circulating blood that originates from apoptosis or necrosis, and elevated cfDNA concentrations have been reported in cancers and other diseases. METHODS In this study, the concentrations and fragment distributions of plasma cfDNA were preliminary investigated in elderly (n = 1) and pediatric (n = 1) patients with acute promyelocytic leukemia (APL)
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The current status of lipoprotein (a) measurement in clinical biochemistry laboratories in the UK: Results of a 2021 national survey. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-08 Saleem Ansari,Robert D Garmany Neely,Jules Payne,Jaimini Cegla
BACKGROUND Lipoprotein(a) (Lp(a)) is now established as a causal risk factor for cardiovascular disease (CVD) and accurate laboratory measurement is of pivotal importance in reducing Lp(a) associated risk. The consensus statement by HEART UK in 2019 included recommendations to improve standardisation of clinical laboratory measurement and reporting of Lp(a). METHODS A 16 question, electronic audit
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Reference intervals for deconjugated urine metanephrines by Bhattacharya analysis. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-02 Bobby Li,Richard King,Christiaan Sies,Simon Thompson,Chris Florkowski
BACKGROUND Urine metanephrines are used to screen for phaeochromocytoma or paraganglioma (PPGL). Current reference intervals (RI) derived in healthy individuals are not age or sex-stratified, and lower than in hypertensive patients, leading to high false positive rates. This study aims to determine age and sex-stratified RI from a contingent screening population. METHODS Patients with 24-h deconjugated
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Validation of the Randox colorimetric assay for serum copper and zinc. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-10-03 Simon Handley,Troy Wanandy,Louise Prentice
Background Serum copper and zinc are measured to assess deficiency and toxicity. Atomic absorption spectrophotometry and mass spectrometry methods are expensive and require highly trained staff. Colorimetric assays are available from Randox which are inexpensive and can be automated. We validated serum copper and zinc colorimetric assays on the Binding Site Optilite analyser including comparison with
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Sample viscosity as a source of analytical error: The role of protein structure and mass concentration. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-09-29 Charlton Agius
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The CELTIC ranges project (comprehensive and effective laboratory test reference intervals for Irish children) methodology and results for renal profile tests in plasma on the Roche modularTM system. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-09-27 Ann Leonard,Turlough Bolger,Eleanor Molloy,Gerard Boran
BACKGROUND The CELTIC ranges project aims to deliver a comprehensive range of reference intervals for commonly ordered laboratory investigations suitable for use in an Irish population as well as enabling comparison with relevant international studies. In this paper, we describe our methodology used throughout the entire project and present paediatric reference intervals for renal profile tests in
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Can artificial intelligence replace biochemists? A study comparing interpretation of thyroid function test results by ChatGPT and Google Bard to practising biochemists. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-09-20 Emma Stevenson,Chelsey Walsh,Luke Hibberd
BACKGROUND Public awareness of artificial intelligence (AI) is increasing and this novel technology is being used for a range of everyday tasks and more specialist clinical applications. On a background of increasing waits for GP appointments alongside patient access to laboratory test results through the NHS app, this study aimed to assess the accuracy and safety of two AI tools, ChatGPT and Google
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Paediatric reference ranges for plasma chromogranin A. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-09-15 Sofie Lieberoth,Frederik Friis-Hansen,Lennart Friis-Hansen
BACKGROUND Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare diseases with varied aggressiveness originating from endocrine cells belonging to the diffuse endocrine system and most often produce and secrete chromogranin A (CgA). CgA in plasma is therefore used to screen, diagnose, and monitor for NENs in both adults and children with sporadic or familial NENs. METHODS Plasma CgA was
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Vitamin B12 reference intervals on Beckman, Roche and Siemens analytical platforms. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-09-12 Nuthar Jassam,Thomas Bancroft,Ahai Luvai,Wycliffe Mbagaya,Julian H Barth
BACKGROUND Vitamin B12 status is assessed primarily by measuring total serum B12 using competitive binding methods. The lack of availability of a standard material and high-level reference measurement procedure affect the trueness of B12 results; this results in variation between methods. This study aimed to determine the reference intervals for vitamin B12 on three routine analytical platforms. METHOD
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Maintaining glucose integrity ex-vivo: Impact of preanalytical specimen handling. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-09-07 Md Nahidul Islam,Claire Lyons,Tomas P Griffin,Siobhan Hamon,Fidelma P Dunne,Paula M O'Shea
BACKGROUND Adopting the WHO protocol for glucose analysis is arguably impractical in the routine clinical setting. Deviations may develop due to a lack of understanding regarding the impact of glycolysis on the accuracy of results. AIM We sought to assess the stability of glucose in two different blood collection tubes (BCT), BD Vacutainer® FX 'Fl-Ox' and Greiner Vacuette® FC-Mix 'FC-Mix' stored at
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Practical approaches to the detection of macrotroponin. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-09-02 Leo Lam,Campbell Kyle
INTRODUCTION Macrotroponin is increasingly recognised as a cause of confusion in interpreting high-sensitivity cardiac troponin (hs-cTnI) results. In this study, we sought to evaluate two practical approaches to detecting macrotroponin. These two approaches are PEG precipitation and SVM (support vector machine) analysis to classify discrepancies between hs-cTn assays. METHOD Residual serum and heparin
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Preliminary evaluation of the diagnostic performance of Roche Elecsys® active vitamin B12 versus total vitamin B12 for vitamin B12 deficiency screening. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-31 Jennifer Guillerme,Guillaume Feugray,Hélène Girot,Valéry Brunel,Muriel Quillard Muraine
INTRODUCTION The prevalence of vitamin B12 deficiency is high in at-risk populations with sometimes irreversible consequences. Beside total B12 (TVB12), active B12 (AVB12) is a promising first-line marker. Only Abbott AVB12 assays were largely evaluated and generally demonstrated benefit in clinical practice. More recently developed Roche AVB12 still requires some investigations. OBJECTIVES Our study
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Current practice and recommendations for managing transgender patient data in clinical laboratories in the United Kingdom and Republic of Ireland. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-30 Sophie Hepburn,Devon Buchanan,Seán J Costelloe
BACKGROUND Transgender people may avoid seeking medical care due to previous negative experiences and fear of discrimination. Clinical laboratories can contribute to a poor patient experience and clinical outcome when the design and functionality of laboratory information management systems (LIMS) do not consider the needs of transgender patients. This survey aimed to capture current practices in United
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Development of blood collection tubes for glucose measurement using adenosine 3-phosphate and sodium fluoride as glycolytic inhibitors. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-30 Yukio Kume,Yuji Hirowatari,Makoto Kurano,Yutaka Yatomi,Makoto Matsushita
BACKGROUND Blood collection tubes with sodium fluoride (NaF) added as a glycolytic inhibitor are widely used for glucose measurement. However, the glycolytic inhibitory effects of NaF are insufficient, and decreases in glucose levels over time after blood collection have become a problem. METHODS Blood from a volunteer collected using an NaF tube was used to compare the glycolysis inhibitory abilities
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UKMedLab2023 conference - A celebration of 70 years of the ACB. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-29 Sarah Robinson,Kath Hayden
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Use of finer needles for venipuncture increases in vitro haemolysis despite reducing persistent pain and nerve injury: A retrospective study. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-29 Hiroshi Umemura,Hiromichi Takahashi,Yoshiaki Fukuda,Hitoshi Soma,Rumiko Aoki,Norihisa Takei,Tomohiro Nakayama
BACKGROUND Although venipuncture is minimally invasive, and is the most frequently performed medical procedure, it carries the small risk of causing persistent pain, including nerve damage. Recently, our hospital stopped using 22-gauge needles for venipuncture in outpatients and switched to using only 23- and 25-gauge needles. We investigated the impact of using only the finer needles on the incidence
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Different serum sodium assay, different model for end stage liver disease - sodium scores in patients awaiting liver transplant: A cross-sectional study. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-20 Fatima Rodriguez-Alvarez,Paulina Moctezuma-Velázquez,Blanca Zuleyma Mota-Ayala,Paul Alonso Pamila-Tecuautzin,Ignacio García-Juárez,Carlos Moctezuma-Velázquez
INTRODUCTION AND AIMS Sodium can be measured with direct or indirect methods; abnormal plasma total protein concentration can impact on sodium measured by indirect ion-selective electrodes (ISE). Serum sodium is an important item to determine the Model for End Stage Liver Disease Sodium (MELD-Na) score, commonly used for liver graft allocation. Patients with cirrhosis usually have hypoproteinemia.
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Interference by paraproteins is an infrequent finding in nine Roche c702 assays. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-10 Alison M Jones,Stuart J Wilkinson
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Analytical assays and bootstrap resampling method to validate performance of the Roche Elecsys STAT highly sensitive troponin T assay and its application for the 'rule-out' part of ESC guidelines for NTSTEMI. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-08-07 David Metsu,Daphné Mille,Carole Pailly,Valerica G Oancea,Luc Essemilaire,Dominique Coppin
BACKGROUND The European Society of Cardiology (ESC) guidelines recommend a dynamic (0-1h) cardiac troponin (cTn) determination for non-ST elevation myocardial infarction diagnosis. For patients with low cTn levels, a discharge from emergency can be considered. Nevertheless, cTn cutoffs for discharge are lower than the limits of quantification proposed by laboratory reagent suppliers. AIM Validate cTn
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Artefactually low creatinine by Beckman Coulter enzymatic method due to immunoglobulin M paraprotein interference. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-07-23 Bobby Li,Simon Thompson,Kareen Igot,Richard King,Matthew Doogue,Chris Florkowski
An 81-year-old man was admitted to hospital with symptomatic coronavirus disease (COVID-19) infection. He had a background of progressive chronic inflammatory demyelinating polyneuropathy associated with Waldenstrom's macroglobulinaemia. His plasma creatinine on four separate samples was inconceivably low (all ≤13 μmol/L), as measured by a Beckman Coulter enzymatic assay) after being 72 μmol/L 3 months
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A further monoclonal antibody-based immunoturbidimetry option for measuring faecal elastase on the Optilite analyser. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-07-20 Alessia Capoferri,Ilenia Infusino,Mauro Panteghini
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A service evaluation of the use of faecal immunochemical tests in symptomatic patients aged under 50 years presenting to primary care. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-07-16 Rebecca E Tibbs,Sally C Benton
BACKGROUND Most colorectal cancers (CRCs) occur in individuals aged over 50 years; however, the incidence in younger age groups is increasing. Diagnosis in younger patients is frequently delayed due to non-specific symptoms and the relative frequency of benign disease. There is a need to identify patients who warrant further investigation for CRC. This study reviewed whether a faecal haemoglobin (f-Hb)
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Standardising the biochemical confirmation of adult male hypogonadism; a joint position statement by the Society for Endocrinology and Association of Clinical Biochemistry and Laboratory Medicine. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-30 Channa N Jayasena,Nipun Lakshitha de Silva,Michael W O'Reilly,Finlay MacKenzie,Rachel Marrington,Hugh Jones,Mark Livingston,Paul Downie,Geoff Hackett,Sud Ramachandran,Jeremy Tomlinson,Janine David,Christopher Boot,Mayur Patel,Julie Tarling,Fredrick Wu,Richard Quinton
Background: Inter-assay variation between different immunoassays and different mass spectrometry methods hampers the biochemical confirmation of male hypogonadism. Furthermore, some laboratories utilis eassay manufacturer reference ranges that do not necessarily mirror assay performance characteristics, with the lower limit of normality ranging from 4.9 nmol/L to 11 nmol/L. The quality of the normative
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First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-26 Paula Sienes Bailo,Nuria Goñi Ros,Bárbara Menéndez Jándula,Ramiro Álvarez Alegret,Eduardo González Gómez,Ricardo González Tarancón,Silvia Izquierdo Álvarez
Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by the proliferation and infiltration of macrophages and hyperactivated T lymphocytes that escape from the physiological control pathways and favour the existence of an environment of excessive inflammation and tissue destruction. HLH has been classified into two types: a primary or familial autosomal recessive form
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Artificially raised creatinine concentrations due to analytical interference for samples contaminated with total parenteral nutrition fluid. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-07-11 Jinny Jeffery,Helen Millar,Rachel Marrington,Finlay MacKenzie,Roanna George
BACKGROUND A sample received in the laboratory from a patient receiving total parenteral nutrition (TPN) indicated that the patient may have renal dysfunction, but the results were not considered to be reliable enough to report. Investigations using a reference method for measurement of creatinine confirmed positive interference in the creatinine assay and distribution of samples via an External Quality
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Example of use of clock time-dependent targets for patient-based quality control. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-22 Douglas F Stickle
BACKGROUND Running means for total calcium (Ca) results at our laboratory exhibit a stable time-of-day (TOD) periodic pattern. We examined use of TOD-dependent targets for running means in patient-based quality control (PBQC) for Ca. METHODS Primary data were Ca results over a 3 month interval, restricted to weekday data within the Ca reference interval (8.5-10.3 mg/dL; 2.12-2.57 mmol/L). Running means
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Increased PD-1 expression of bone marrow T-cells in acute myeloid leukaemia patients after stem cell transplantation, and its association with overall survival. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-11-21 Eunkyoung You,Chan-Jeoung Park,Young-Uk Cho,Seongsoo Jang,Min Young Lee,Hery Kim,Kyung Nam Koh,Ho Joon Im,Eun-Ji Choi,Je-Hwan Lee,Kyoo-Hyung Lee
BACKGROUND Immune checkpoints are involved in mechanisms by which tumours escape from the host immune system. Our aim was to evaluate acute myeloid leukaemia (AML) patients to determine expression levels of checkpoint molecules according to diagnosis and treatments, and to identify optimal candidates for checkpoint blockade. METHODS Bone marrow (BM) samples were obtained from 279 AML patients at different
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Effect of multiple loading FIT sample collection devices on faecal haemoglobin concentration. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-10-06 Cerin John,Carolyn Piggott,Sally C Benton
BACKGROUND Faecal immunochemical tests (FIT) are routinely used in colorectal cancer (CRC) screening programmes around the world. More recently, quantitative FIT has been recommended to help triage patients presenting to primary care with symptoms suggestive of CRC. Participants collect faecal samples using sampling probes which are inserted into sample collection devices (SCDs) containing preservative
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The diagnostic utility of IgG index and oligoclonal bands for multiple sclerosis in a neurology hospital patient population. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-05 Francesca Shaw,Carrie Chadwick
BACKGROUND Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Diagnosis is based on the 2017 revised McDonald criteria. Unmatched oligoclonal bands (OCB) within the CSF (i.e. positive OCB) can substitute for dissemination in time by magnetic resonance imaging (MRI). Simonsen et al. (2020) claimed a raised (>0.7) immunoglobulin G (IgG) index could replace OCB status
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National recommendations to standardise acute kidney injury detection and alerting. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-14 Rachel Marrington,Anna L Barton,Alexandra Yates,William McKane,Nicholas M Selby,Jonathan S Murray,James F Medcalf,Finlay MacKenzie,Martin Myers
BACKGROUND National Health Service England issued a Patient Safety Alert in 2014 mandating all acute Trusts in England to implement Acute Kidney Injury (AKI) warning stage results and to do so using a standardised algorithm. In 2021, the Renal and Pathology Getting It Right First Time (GIRFT) teams found significant variation in AKI reporting across the UK. A survey was designed to capture information
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Dataset dependency of low-density lipoprotein-cholesterol estimation by machine learning. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-05 Ishida Hidekazu,Hiroki Nagasawa,Yasuko Yamamoto,Hiroki Doi,Midori Saito,Yuya Ishihara,Takashi Fujita,Mariko Ishida,Yohei Kato,Ryosuke Kikuchi,Hidetoshi Matsunami,Masao Takemura,Hiroyasu Ito,Kuniaki Saito
OBJECTIVES We evaluated the applicability of a machine learning-based low-density lipoprotein-cholesterol (LDL-C) estimation method and the influence of the characteristics of the training datasets. METHODS Three training datasets were chosen from training datasets: health check-up participants at the Resource Center for Health Science (N = 2664), clinical patients at Gifu University Hospital (N =
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Serum cortisol assay performance following the 1 mg overnight dexamethasone suppression test. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-30 Jonathan S Atkins,James M Hawley,Laura J Owen,Jonathan Clayton,Jonathan Scargill,Brian G Keevil
BACKGROUND The 1 mg overnight dexamethasone suppression test (ONDST) is recommended for the differential diagnosis of Cushing's syndrome and the investigation of adrenal incidentalomas. Despite documented variation in serum cortisol immunoassay performance, little has been published regarding its effect on the ONDST. AIMS Assess the performance of three immunoassay platforms (Roche Elecsys II, Abbott
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Measurement of cholesterol levels of lipoprotein subclasses in human serum using anion-exchange high-performance liquid chromatography with a linear concentration gradient of sodium perchlorate. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-06-02 Riku Ito,Daisuke Manita,Hidekatsu Yanai,Yuji Hirowatari
BACKGROUND Relationships between the subclasses of high-density lipoprotein (HDL) or low-density lipoprotein (LDL) and the risk of atherosclerotic cardiovascular disease have been studied, and using various methods, such as ultracentrifugation, electrophoresis, and nuclear magnetic resonance, for analysing lipoprotein subclasses. We established a method for HDL and LDL subclasses using anion-exchange
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Determination of in vitro stability of routine haematinics tests using EFLM standards and the CRESS checklist Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-05-09 Robert Daniel Williams, Chris J Duff, Alexandra Marie Yates
Background: Laboratories should be are aware of stability of the analytes they are testing in order to avoid incorrect reporting and patient management. Stability studies are difficult to interpret...
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Variation of eGFR reporting and CKD equations used in the United Kingdom Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-05-09 Rachel Marrington, Finlay Mackenzie
Background UK Clinical laboratories have been routinely reporting an estimated Glomerular Filtration Rate (eGFR) based on creatinine measurements using an eGFR equation since the early 2000s. Thoug...
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Detection of serum M-protein in acetonitrile pecipitates by MALDI-TOF mass spectrometry: A novel, low-cost methodology Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-05-09 Nikita Mehra, Gopal Gopisetty, Jayavelu Subramani, Sariga Dhanasekar, Arivazhagan Rajamanickam, Jayachandran Perumal Kalaiyarasi, Parathan Karunakaran, Krishnarathinam Kannan, Swaminathan Rajaraman, Thangarajan Rajkumar
BackgroundSeveral studies have demonstrated the analytical sensitivity of MALDI-TOF mass spectrometry (MALDI-TOF MS) by immunoenrichment for M-protein analysis. We report the results of a novel, lo...
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The role of the laboratory in the diagnosis of an unusual case of Waldenstrom’s macroglobulinaemia that lacked the common clinical features: A case report Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-28 Philip Logue, W Ian Deighan, Sumana Gidwani, Aaron Niblock
Lymphoplasmacytic lymphoma (LPL) is a neoplasm of small B lymphocytes, plasmacytoid lymphocytes and plasma cells usually involving the bone marrow (BM). A subset of LPL which is associated with IgM...
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Growth mindset of meaning in Life: Viewing meaning in life as malleable matters Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-18 Zhen Huang, Yiwen Wu, Yukun Zhao, Kaiping Peng
Meaning in life contributes to psychological well-being. However, few studies have adopted an implicit theory approach to studying people's beliefs about the malleability of meaning in life. We pro...
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Understanding how virtual care has shifted primary care interactions and patient experience: A qualitative analysis Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-18 Kelly Wu, Marlena Dang Nguyen, Geneviève Rouleau, Rhea Azavedo, Diya Srinivasan, Laura Desveaux
IntroductionThe widespread and rapid implementation of virtual care has introduced evolutionary changes in the context, process, and way primary care is delivered. The objectives of this study were...
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Artificial intelligence assisted telehealth for nursing: A scoping review Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-18 Jeeyae Choi, Seoyoon Woo, Anastasiya Ferrell
BackgroundDue to the COVID-19 pandemic, telehealth resurfaced as a convenient efficient healthcare delivery method. Researchers indicate that Artificial Intelligence (AI) could further facilitate d...
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Strategic Leaders and Corporate Social Responsibility: A Meta-Analytic Review Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-18 Gang Wang, Richard A. Devine, Gonzalo Molina-Sieiro, R. Michael Holmes, Jr.
A large body of literature has focused on strategic leaders’ (i.e., CEOs’, TMT members’, and board directors’) influence on corporate social responsibility (CSR). However, inconsistent findings hav...
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Beyond Income: Dynamic Consumer Financial Vulnerability Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-18 Linda Court Salisbury, Gergana Y. Nenkov, Simon J. Blanchard, Ronald Paul Hill, Alexander L. Brown, Kelly D. Martin
This research challenges the entrenched belief that financial vulnerability affects only low-income consumers. Instead, most consumers across the socioeconomic spectrum experience varying degrees o...
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Effect of secretory DKK3 on circulating CD56bright natural killer cells in patients with liver cancer Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-18 Da-Hua Liu, Gui-Min Wen, Chang-Liang Song, Pu Xia
BackgroundLiver cancer seriously threatens human health. Natural killer (NK) cells are an important part of the innate immune system and have strong anti-tumor ability. Immunotherapy based on NK ce...
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Evaluation of the two-point calibration bromocresol green method, showing reduced deviation from the bromocresol purple method in sera from patients with hypoalbuminemia Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-04 tatsuya iwasaki, Kazuki Nakajima, Yuji Hirowatari, Makoto Matsushita
Background: The bromocresol green (BCG) and bromocresol purple (BCP) methods are widely used for albumin measurements in routine testing, but the BCG method is known to react with globulin fraction...
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EQA: There’s not a glitch in the matrix. Investigation of CRP bias on the Roche Cobas c701 Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-04 Emma Stevenson, Chelsey Walsh, Sadie Thomas
Background: The Roche Cobas c Tina-quant C-Reactive Protein (CRP) IV method has shown persistent, significant negative bias compared to other methodologies in the UK NEQAS external quality assuranc...
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Implementing cardiovascular precision diagnostics: laboratory specialists as catalysts? Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-04-05 Christa M Cobbaert
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Subjects used to calculate pregnancy-specific reference intervals must exclude those who are overweight or obese. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-03-19 William Tormey
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Exclusion criteria for reference studies: Context is key. Ann. Clin. Biochem. (IF 2.2) Pub Date : 2023-03-19 Samuel Dockree,Brian Shine,Tim James,Manu Vatish