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Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas Modern Pathol. (IF 7.5) Pub Date : 2024-03-18 Amir Momeni-Boroujeni, Kerry Mullaney, Sara E. DiNapoli, Mario M. Leitao Jr., Martee L. Hensley, Nora Katabi, Douglas H.R. Allison, Kay J. Park, Cristina R. Antonescu, Sarah Chiang
Recurrent gene fusions have been observed in epithelioid and myxoid variants of uterine leiomyosarcoma. fusion was recently described in a subset of epithelioid leiomyosarcomas exhibiting rhabdoid morphology. In this study, we sought to expand the clinical, morphologic, immunohistochemical, and genetic features of gynecologic leiomyosarcomas harboring rearrangement with and novel fusion partners. We
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High-Grade, Non-Sarcomatoid Chromophobe Renal Cell Carcinoma: A Series of 22 Cases with Novel Molecular Features on A Subset Modern Pathol. (IF 7.5) Pub Date : 2024-03-14 Ezra G. Baraban MD, Roy Elias MD, Ming-Tseh Lin MD PhD, Yasser Ged MD, Jing Zhu, Aparna Pallavajjala, Nirmish Singla MD, Tamara L. Lotan MD, Pedram Argani MD, James R. Eshleman MD PhD, Jonathan I. Epstein MD
Chromophobe renal cell carcinoma (ChRCC) is the third most common subtype of renal cell carcinoma, and typically exhibits indolent behavior, though a rare subset can exhibit high-grade morphological features and are associated with a poor prognosis. Although there is limited data on the molecular characteristics of metastatic and sarcomatoid ChRCC, the molecular features of high-grade non-sarcomatoid
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Amplification of mutant NRAS in melanocytic tumors with features of Spitz tumors Modern Pathol. (IF 7.5) Pub Date : 2024-03-10 Jeffrey M. Cloutier, Meng Wang, Swapna S. Vemula, Sonia Mirza, Jingly Weier, Jamie D. Aquino, Timothy H. McCalmont, Philip E. LeBoit, Boris C. Bastian, Iwei Yeh
activating mutations are prevalent in melanocytic neoplasia, occurring in a subset of common acquired melanocytic nevi and approximately 30% of cutaneous melanomas. In this study, we describe a cohort of seven distinctive melanocytic tumors characterized by activating point mutations in codon 61 of with amplification of the mutant allele and shared clinicopathologic features. These tumors occurred
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Intra-abdominal epithelioid neoplasm with EWSR1::CREB fusions involving the kidney: A clinicopathologic and molecular characterization with an emphasis on differential diagnosis Modern Pathol. (IF 7.5) Pub Date : 2024-03-07 Ming Zhao MD, Hualei Gan MD, Shan Zhong MD, Qiuyan Xia MD PhD, Yanfeng Bai MD, Jiayun Xu MS, Xiaodong Teng MD, Jian Wang MD PhD
Soft tissue neoplasms harboring fusions between or with genes encoding CREB transcription factors family (ATF1, CREB1, and CREM) are an emerging heterogeneous group of mesenchymal tumors that differ significantly in morphology, immunophenotypes, and behavior. Recently, :: fusions have been recognized to define a group of aggressive neoplasms of epithelioid morphology with multiple growth patterns and
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L1CAM Expression and Molecular Alterations Distinguish Low Grade Oncocytic Tumor (LOT) from Eosinophilic Chromophobe Renal Cell Carcinoma Modern Pathol. (IF 7.5) Pub Date : 2024-03-07 Mohammed Alghamdi, Jie-Fu Chen, Achim Jungbluth, Sirma Koutzaki, Matthew B. Palmer, Hikmat A. Al-Ahmadie, Samson W. Fine, Anuradha Gopalan, Judy Sarungbam, S. Joseph Sirintrapun, Satish K. Tickoo, Victor E. Reuter, Ying-Bei Chen
Renal low-grade oncocytic tumor (LOT) is a recently recognized renal cell neoplasm designated within the “other oncocytic tumors” category in the 2022 WHO Classification. While the clinicopathologic, immunohistochemical, and molecular features reported for LOT have been largely consistent, the data is relatively limited. The morphologic overlap between LOT and other low grade oncocytic neoplasms, particularly
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5TH EDITION OF THE WORLD HEALTH ORGANIZATION CLASSIFICATION OF TUMORS OF THE HEMATOPOIETIC AND LYMPHOID TISSUES Modern Pathol. (IF 7.5) Pub Date : 2024-03-07 John K. Choi, Wenbin Xiao, Xueyan Chen, Sanam Loghavi, Kojo S. Elenitoba-Johnson, Kikkeri N. Naresh, L. Jeffrey Medeiros, Magdalena Czader, WHO 5th edition classification project
This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage, mixed-phenotype acute leukemias, myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangements, histiocytic and dendritic neoplasms and genetic tumor syndromes of the 5 edition of the World Health Organization Classification
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Profiling of copy number alterations using low-coverage whole-genome sequencing informs differential diagnosis and prognosis in primary cutaneous follicle center lymphoma Modern Pathol. (IF 7.5) Pub Date : 2024-03-07 Bence Bátai, Laura Kiss, Luca Varga, Ákos Nagy, Jacob Househam, Ann-Marie Baker, Tamás László, Anna Udvari, Róbert Horváth, Tibor Nagy, Judit Csomor, József Szakonyi, Tamás Schneider, Trevor A. Graham, Donát Alpár, Jude Fitzgibbon, Ágota Szepesi, Csaba Bödör
Primary cutaneous follicle center lymphoma (PCFCL) has an excellent prognosis using local treatment, while nodal follicular lymphoma (nFL) occasionally presenting with cutaneous spread, often requires systemic therapy. Distinction of the two diseases based on histopathology alone might be challenging. Copy number alterations (CNAs) have scarcely been explored on a genome-wide scale in PCFCL, yet they
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CHRNA6 RNA in situ hybridization is a useful tool for the diagnosis of extraskeletal myxoid chondrosarcoma Modern Pathol. (IF 7.5) Pub Date : 2024-03-05 Ben W. Dulken, Leandra Kingsley, Sabrina Zdravkovic, Oscar Cespedes, Xiaohua Qian, David I. Suster, Gregory W. Charville
Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon mesenchymal neoplasm characteristically composed of uniform-appearing round to spindle-shaped cells with eosinophilic cytoplasm and abundant myxoid extracellular matrix. While the majority of cases harbor a pathognomonic t(9;22) translocation that fuses with the orphan nuclear receptor , there are less common variants that partner with , , or
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Molecular and Clinical Portrait of HER2-low Invasive Lobular Carcinomas Modern Pathol. (IF 7.5) Pub Date : 2024-02-28 Lounes Djerroudi, Ahmad El Sabeh-Ayoun, Camille Benoist, Gaelle Pierron, Julien Masliah-Planchon, Laetitia Fuhrmann, Yann Kieffer, Matthieu Carton, Toulsie Ramtohul, Celine Callens, Victor Renault, François-Clément Bidard, Fatima Mechta-Grigoriou, Anne Vincent-Salomon
Invasive lobular carcinomas (ILCs) have a low frequency of amplification, therefore restricting the use of conventional anti-HER2 therapies for this histologic special type. Conversely, ILCs with low HER2 overexpression may represent a broader target for the use of emerging antibody drug conjugate therapies targeting HER2, since these treatments have proven effective in HER2-low breast cancers. Very
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Upgrade Rates of Variant Lobular Carcinoma In Situ Compared to Classic Lobular Carcinoma In Situ Diagnosed in Core Needle Biopsies: A 10-Year Single Institution Retrospective Study Modern Pathol. (IF 7.5) Pub Date : 2024-02-28 Lakshmi Harinath, Tatiana M. Villatoro, Beth Z. Clark, Jeffrey L. Fine, Jing Yu, Gloria J. Carter, Emilia Diego, Priscilla F. McAuliffe, Phuong Mai, Amy Lu, Margarita Zuley, Wendie A. Berg, Rohit Bhargava
The primary aim of this study was to determine the upgrade rates of variant lobular carcinoma in situ (V-LCIS, ie, combined florid [F-LCIS] and pleomorphic [P-LCIS]) compared with classic LCIS (C-LCIS) when diagnosed on core needle biopsy (CNB). The secondary goal was to determine the rate of progression/development of invasive carcinoma on long-term follow-up after primary excision. After institutional
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Atypical Spindle Cell/Pleomorphic Lipomatous Tumor With Sarcomatous Transformation: Clinicopathologic and Molecular Analysis of 4 Cases Modern Pathol. (IF 7.5) Pub Date : 2024-02-27 Raul Perret, Gregory W. Charville, Melissa Alame, Flora Rebier, Isabelle Soubeyran, John M. Gross, Daniel Graham, Donald C. Green, Darcy A. Kerr, Wahab A. Khan, Jeffrey M. Cloutier
Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently described adipocytic tumor predominantly affecting the subcutaneous soft tissues of adults. Previous studies have shown that ASPLT follows a benign clinical course with a 4% to 12% local recurrence rate and no risk of dedifferentiation. Herein, we describe the clinicopathologic and molecular findings of 4 cases of ASPLT showing
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Pathologic Assessment and Staging of Multiple Non–Small Cell Lung Carcinomas: A Paradigm Shift with the Emerging Role of Molecular Methods Modern Pathol. (IF 7.5) Pub Date : 2024-02-21 Jason Chang, Natasha Rekhtman
Non–small cell lung carcinomas (NSCLCs) commonly present as 2 or more separate tumors. Biologically, this encompasses 2 distinct processes: separate primary lung carcinomas (SPLCs), representing independently arising tumors, and intrapulmonary metastases (IPMs), representing intrapulmonary spread of a single tumor. The advent of computed tomography imaging has substantially increased the detection
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HistoEM: A Pathologist-Guided and Explainable Workflow Using Histogram Embedding for Gland Classification Modern Pathol. (IF 7.5) Pub Date : 2024-02-16 Alessandro Ferrero, Elham Ghelichkhan, Hamid Manoochehri, Man Minh Ho, Daniel J. Albertson, Benjamin J. Brintz, Tolga Tasdizen, Ross T. Whitaker, Beatrice S. Knudsen
Pathologists have, over several decades, developed criteria for diagnosing and grading prostate cancer. However, this knowledge has not, so far, been included in the design of convolutional neural networks (CNN) for prostate cancer detection and grading. Further, it is not known whether the features learned by machine-learning algorithms coincide with diagnostic features used by pathologists. We propose
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Whole-Genome Sequencing Analysis of Male Breast Cancer Unveils Novel Structural Events and Potential Therapeutic Targets Modern Pathol. (IF 7.5) Pub Date : 2024-02-16 Majd Al Assaad, Olivier Michaud, Alissa Semaan, Michael Sigouros, Marvel Tranquille, Andy Phan, Max F. Levine, Gunes Gundem, Juan S. Medina-Martínez, Elli Papaemmanuil, Jyothi Manohar, David Wilkes, Andrea Sboner, Syed A.F. Hoda, Olivier Elemento, Juan Miguel Mosquera
The molecular characterization of male breast cancer (MaBC) has received limited attention in research, mostly because of its low incidence rate, accounting for only 0.5% to 1% of all reported cases of breast cancer each year. Managing MaBC presents significant challenges, with most treatment protocols being adapted from those developed for female breast cancer. Utilizing whole-genome sequencing (WGS)
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Unraveling the Significance of MET Focal Amplification in Lung Cancer: Integrative NGS, FISH, and IHC Investigation Modern Pathol. (IF 7.5) Pub Date : 2024-02-16 Chan Xiang, Xinze Lv, Ke Chen, Lianying Guo, Ruiying Zhao, Haohua Teng, Min Ye, Ting Kuang, Ting Hou, Chenglin Liu, Haiwei Du, Zhou Zhang, Yuchen Han
amplification (amp) represents a promising therapeutic target in non–small cell lung cancer, but no consensus has been established to identify amp-dependent tumors that could potentially benefit from MET inhibitors. In this study, an analysis of amplification/overexpression status was performed in a retrospectively recruited cohort comprising 231 patients with non–small cell lung cancer from Shanghai
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Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer Modern Pathol. (IF 7.5) Pub Date : 2024-02-16 Hanna Elomaa, Jouni Härkönen, Sara A. Väyrynen, Maarit Ahtiainen, Shuji Ogino, Jonathan A. Nowak, Mai Chan Lau, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Väyrynen
Indoleamine 2,3-dioxygenase (IDO) and arginase-1 (ARG1) are amino acid–metabolizing enzymes, frequently highly expressed in cancer. Their expression may deplete essential amino acids, lead to immunosuppression, and promote cancer growth. Still, their expression patterns, prognostic significance, and spatial localization in the colorectal cancer microenvironment are incompletely understood. Using a
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Prognostic Significance of Tumor-Infiltrating Lymphocytes and High-Risk Human Papillomavirus in Ocular Sebaceous Carcinoma: A Comprehensive Analysis Modern Pathol. (IF 7.5) Pub Date : 2024-02-16 Se Un Jeong, Joon Seon Song, Hee Jin Lee, Ho-Seok Sa, Kyung-Ja Cho
High-risk human papillomavirus (hrHPV) and tumor-infiltrating lymphocytes (TILs) are known to have prognostic significance in oropharyngeal squamous cell carcinoma. However, their significance in ocular sebaceous carcinoma (OSC) remains unverified because of the rarity of the condition. This study aimed to investigate the association between clinicopathologic features, biomarkers, and hrHPV infection
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Toward Deploying a Deep Learning Model for Diagnosis of Rhabdomyosarcoma Modern Pathol. (IF 7.5) Pub Date : 2024-02-08 David Joon Ho, Narasimhan P. Agaram, Arthur O. Frankel, Melvin Lathara, Daniel Catchpoole, Charles Keller, Meera R. Hameed
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SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors Modern Pathol. (IF 7.5) Pub Date : 2024-01-23 Nicolas Macagno, Thibault Kervarrec, Soumanth Thanguturi, Pierre Sohier, Daniel Pissaloux, Lenaïg Mescam, Marie-Laure Jullie, Eric Frouin, Amelie Osio, Monique Faisant, François Le Loarer, Bernard Cribier, Eduardo Calonje, Evelyn Vanesa Erazo Luna, Daniela Massi, Keisuke Goto, Haruto Nishida, Sandrine Paindavoine, Aurelie Houlier, Juliet Tantot, Nazim Benzerdjeb, Franck Tirode, Arnaud De la Fouchardière
Cutaneous mixed tumors exhibit a wide morphologic diversity and are currently classified into apocrine and eccrine types based on their morphologic differentiation. Some cases of apocrine-type cutaneous mixed tumors (ACMT), namely, hyaline cell–rich apocrine cutaneous mixed tumors (HCR-ACMT) show a prominent or exclusive plasmacytoid myoepithelial component. Although recurrent fusions of have been
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Prostate Cancer Risk Stratification by Simple Scoring of the Current pT3 Lesions: A Proposal for a New Pathologic T-Staging System Modern Pathol. (IF 7.5) Pub Date : 2024-01-23 Hiroshi Miyamoto, Yuki Teramoto, Numbereye Numbere, Ying Wang, Jean V. Joseph
Cancer spread beyond the prostate, including extraprostatic extension (other than seminal vesicle or bladder invasion; EPE)/microscopic bladder neck invasion and seminal vesicle invasion (SVI) currently classified as pT3a and pT3b lesions, respectively, does not uniformly indicate poor oncologic outcomes. Accurate risk stratification of current pT3 disease is therefore required. We herein further determined
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Molecular Screening in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling Modern Pathol. (IF 7.5) Pub Date : 2024-01-23 Marketa Kalinova, Marcela Mrhalova, Edita Kabickova, Michael Svaton, Aneta Skotnicova, Zuzana Prouzova, Zdenka Krenova, Alexandra Kolenova, Martina Divoka, Eva Fronkova, Roman Kodet
Anaplastic lymphoma kinase–positive anaplastic large cell lymphoma (ALK+ ALCL) originates from the T-lineage and is marked by rearrangements of the gene. More than 10 fusion partners with the gene are known, with the most common being the t(2;5)(p23;q35) translocation resulting in the fusion. In 10% to 20% of the ALK+ ALCL cases, the gene fuses with various other partners. Modern molecular techniques
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Systematic Characterization of the Clinical and Pathological Features of Schwannomas Harboring SH3PXD2A::HTRA1 Fusion Modern Pathol. (IF 7.5) Pub Date : 2024-01-12 Jen-Chieh Lee, Pei-Hang Lee, Sung-Chou Li, Kuan-Cho Liao, Yi-Ming Chang, Hui-Chun Chen, Yu-Chien Kao, Pao-Shu Wu, Shih-Chiang Huang, Jen-Wei Tsai, Chia-Fa Hu, Chih-Hao Li, Ting-Ting Liu, Shih-Chen Yu, Jui-Chu Wang, Hsuan-Ying Huang
The understanding of schwannoma tumorigenesis has been reshaped by the recent identification of :: fusion in 10% of intracranial/spinal schwannomas. Nonetheless, pathologic features of schwannomas harboring this fusion, as well as its prevalence outside intracranial/spinal locations, have not been characterized. We screened 215 consecutive schwannomas for their clinicopathologic characteristics and
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Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Immunohistochemistry Can Be a Useful Ancillary Tool to Identify Perivascular Epithelioid Cell Tumor Modern Pathol. (IF 7.5) Pub Date : 2024-01-12 Sintawat Wangsiricharoen, Davis R. Ingram, Rohini R. Morey, Khalida Wani, Alexander J. Lazar, Wei-Lien Wang
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors that express smooth muscle and melanocytic makers. Diagnosis of PEComas can be challenging due to focal or lost expression of traditional immunohistochemical markers, limited availability of molecular testing, and morphological overlap with much more common smooth muscle tumors. This study evaluates the use of glycoprotein nonmetastatic
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High-Plex Assessment of Biomarkers in Tumors Modern Pathol. (IF 7.5) Pub Date : 2024-01-12 Thazin N. Aung, Katherine M. Bates, David L. Rimm
The assessment of biomarkers plays a critical role in the diagnosis and treatment of many cancers. Biomarkers not only provide diagnostic, prognostic, or predictive information but also can act as effective targets for new pharmaceutical therapies. As the utility of biomarkers increases, it becomes more important to utilize accurate and efficient methods for biomarker discovery and, ultimately, clinical
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Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2 Modern Pathol. (IF 7.5) Pub Date : 2024-01-12 Jessica M. Posada, Evgeny Yakirevich, Ashish M. Kamat, Akshay Sood, Joseph M. Jacob, Gennady Bratslavsky, Petros Grivas, Philippe E. Spiess, Roger Li, Andrea Necchi, Anthony E. Mega, Dragan J. Golijanin, Dean Pavlick, Richard S.P. Huang, Douglas Lin, Natalie Danziger, Ethan S. Sokol, Smruthy Sivakumar, Jeffrey S. Ross, Liang Cheng
The micropapillary subtype of urothelial carcinoma (MPUC) of the bladder is a very aggressive histological variant of urothelial bladder cancer (UBC). A high frequency of MPUC contains activating mutations in the extracellular domain (ECD) of . We sought to further characterize ECD-mutated MPUC to identify additional genomic alterations that have been associated with tumor progression and therapeutic
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Molecular and Clinicopathologic Characterization of Mismatch Repair-Deficient Endometrial Carcinoma Not Related to MLH1 Promoter Hypermethylation Modern Pathol. (IF 7.5) Pub Date : 2024-01-06 Merve Kaya, Cathalijne C.B. Post, Carli M. Tops, Maartje Nielsen, Emma J. Crosbie, Alexandra Leary, Linda R. Mileshkin, Kathy Han, Paul Bessette, Stephanie M. de Boer, Ina M. Jürgenliemk-Schulz, Ludy Lutgens, Jan J. Jobsen, Marie A.D. Haverkort, Remi A. Nout, Judith Kroep, Carien L. Creutzberg, Vincent T.H.B.M. Smit, Nanda Horeweg, Tom van Wezel, Tjalling Bosse
Universal tumor screening in endometrial carcinoma (EC) is increasingly adopted to identify individuals at risk of Lynch syndrome (LS). These cases involve mismatch repair-deficient (MMRd) EC without promoter hypermethylation (PHM). LS is confirmed through the identification of germline MMR pathogenic variants (PV). In cases where these are not detected, emerging evidence highlights the significance
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Tissue Contamination Challenges the Credibility of Machine Learning Models in Real World Digital Pathology Modern Pathol. (IF 7.5) Pub Date : 2024-01-06 Ismail Irmakci, Ramin Nateghi, Rujoi Zhou, Mariavittoria Vescovo, Madeline Saft, Ashley E. Ross, Ximing J. Yang, Lee A.D. Cooper, Jeffery A. Goldstein
Machine learning (ML) models are poised to transform surgical pathology practice. The most successful use attention mechanisms to examine whole slides, identify which areas of tissue are diagnostic, and use them to guide diagnosis. Tissue contaminants, such as floaters, represent unexpected tissue. Although human pathologists are extensively trained to consider and detect tissue contaminants, we examined
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Comparison of Immunohistochemistry, Next-generation Sequencing and Fluorescence In Situ Hybridization for Detection of MTAP Loss in Pleural Mesothelioma Modern Pathol. (IF 7.5) Pub Date : 2024-01-05 Christopher A. Febres-Aldana, Jason C. Chang, Achim A. Jungbluth, Prasad S. Adusumilli, Francis M. Bodd, Denise Frosina, Jerica A. Geronimo, Enmily Hernandez, Helen Irawan, Michael D. Offin, Natasha Rekhtman, William D. Travis, Chad Vanderbilt, Marjorie G. Zauderer, Yanming Zhang, Marc Ladanyi, Soo-Ryum Yang, Jennifer L. Sauter
9p21 deletions involving genes are detected in diffuse pleural mesotheliomas (DPM) but are absent in benign mesothelial proliferations. Loss of MTAP expression by immunohistochemistry (IHC) is well accepted as a surrogate for 9p21 deletion to support a diagnosis of DPM. Accurate interpretation can be critical in the diagnosis of DPM, but variations in antibody performance may impact interpretation
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Poor Diagnostic Reproducibility in the Identification of Nonconventional Dysplasia in Colitis Impacts the Application of Histologic Stratification Tools Modern Pathol. (IF 7.5) Pub Date : 2023-12-27 Nadia Nasreddin, Marnix Jansen, Maurice B. Loughrey, Lai Mun Wang, Viktor H. Koelzer, Manuel Rodriguez-Justo, Marco Novelli, Jennifer Fisher, Matthew W. Brown, Ibrahim Al Bakir, Ailsa L. Hart, Philip Dunne, Trevor A. Graham, Simon J. Leedham
Due to their increased cancer risk, patients with longstanding inflammatory bowel disease are offered endoscopic surveillance with concomitant histopathologic assessments, aimed at identifying dysplasia as a precursor lesion of colitis-associated colorectal cancer. However, this strategy is beset with difficulties and limitations. Recently, a novel classification criterion for colitis-associated low-grade
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EWSR1::WT1 Fusions in Neoplasms Other Than Conventional Desmoplastic Small Round Cell Tumor: Three Tumors Occurring Outside the Female Genital Tract Modern Pathol. (IF 7.5) Pub Date : 2023-12-27 Laura M. Warmke, Raul Perret, Pauline Ledoux, Audrey Michot, Antoine Italiano, Ying S. Zou, Andres Matoso, Pedram Argani, Thomas M. Ulbright, Daniel Baumhoer, Baptiste Ameline, John M. Gross
Desmoplastic small round cell tumor (DSRCT) is a high-grade, primitive round cell sarcoma classically associated with prominent desmoplastic stroma, coexpression of keratin and desmin, and a characteristic :: gene fusion. DSRCT typically arises in the abdominopelvic cavity of young males with diffuse peritoneal spread and poor overall survival. Although originally considered to be pathognomonic for
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Artificial Intelligence-Based Mitosis Scoring in Breast Cancer: Clinical Application Modern Pathol. (IF 7.5) Pub Date : 2023-12-27 Asmaa Ibrahim, Mostafa Jahanifar, Noorul Wahab, Michael S. Toss, Shorouk Makhlouf, Nehal Atallah, Ayat G. Lashen, Ayaka Katayama, Simon Graham, Mohsin Bilal, Abhir Bhalerao, Shan E. Ahmed Raza, David Snead, Fayyaz Minhas, Nasir Rajpoot, Emad Rakha
In recent years, artificial intelligence (AI) has demonstrated exceptional performance in mitosis identification and quantification. However, the implementation of AI in clinical practice needs to be evaluated against the existing methods. This study is aimed at assessing the optimal method of using AI-based mitotic figure scoring in breast cancer (BC). We utilized whole slide images from a large cohort
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PATZ1-rearranged tumors of the central nervous system: characterization of a pediatric series of seven cases. Modern Pathol. (IF 7.5) Pub Date : 2023-11-23 Sabrina Rossi,Sabina Barresi,Giovanna Stefania Colafati,Silvia Genovese,Chantal Tancredi,Valentino Costabile,Sara Patrizi,Isabella Giovannoni,Sofia Asioli,Pietro Luigi Poliani,Marina Paola Gardiman,Antonello Cardoni,Giada Del Baldo,Manila Antonelli,Francesca Gianno,Eleonora Piccirilli,Giorgia Catino,Licia Martucci,Denise Quacquarini,Francesco Toni,Fraia Melchionda,Elisabetta Viscardi,Mino Zucchelli
PATZ1: rearranged sarcomas are well recognized tumors as part of the family of round cell sarcoma with EWSR1-non-ETS fusions. Whether PATZ1-rearranged Central Nervous System (CNS) tumors are a distinct tumor type is debatable. We thoroughly characterized a pediatric series of PATZ1-rearranged CNS tumors by Chromosome Microarray Analysis (CMA), DNA methylation analysis, gene expression profiling and
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Comprehensive genomic analysis of cemento-ossifying fibroma. Modern Pathol. (IF 7.5) Pub Date : 2023-11-21 Ricardo Santiago Gomez,Ahmed El Mouatani,Filipe Fideles Duarte-Andrade,Thais Dos Santos Fontes Pereira,Letícia Martins Guimarães,Tenzin Gayden,Damien Faury,Emily M Nakada,Sylvie Langlois,Daniel Sinnett,Wagner Henriques de Castro,Marina Gonçalves Diniz,Nada Jabado,Carolina Cavalieri Gomes
Cemento-ossifying fibroma (COF) of the jaws is currently classified as a benign mesenchymal odontogenic tumor and only targeted approaches have been used to assess its genetic alterations. A minimal proportion of COFs harbor CDC73 somatic mutations, and copy number alterations (CNAs) involving chromosomes 7 and 12 have recently been reported in a small proportion of cases. However, the genetic background
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Comparative Clinicopathological and Genomic Analysis of Hepatocellular Neoplasm, NOS and Hepatoblastoma. Modern Pathol. (IF 7.5) Pub Date : 2023-11-20 Shengmei Zhou,Stephen F Sarabia,Dolores Estrine,Dejerianne Ostrow,Ryan J Schmidt,Mikako Warren,Gordana Raca,Nick Shillingford,Larry Wang,Bruce Pawel,James E Stein,Jaclyn A Biegel,Dolores Lopez-Terrada,Leo Mascarenhas,Jianling Ji
Accurate diagnosis and treatment of hepatocellular neoplasm, not otherwise specified (HCN-NOS), poses significant challenges. Our study aimed to investigate the clinicopathological and genomic similarities and differences between HCN-NOS and hepatoblastoma (HB) to guide diagnostic and treatment strategies. The clinicopathological characteristics of 16 patients with HCN-NOS and 23 patients with HB were
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GLI1-altered mesenchymal tumors with ACTB or PTCH1 fusion: a molecular and clinicopathologic analysis. Modern Pathol. (IF 7.5) Pub Date : 2023-11-20 Darcy A Kerr,Jeffrey M Cloutier,Matthew Margolis,Douglas A Mata,Nathalie J Rodrigues Simoes,William C Faquin,Dora Dias-Santagata,Shefali Chopra,Gregory W Charville,Sintawat Wangsiricharoen,Alexander J Lazar,Wei-Lien Wang,Andrew E Rosenberg,Julie Y Tse
Mesenchymal tumors with GLI1 fusions or amplifications have recently emerged as a distinctive group of neoplasms. The terms GLI1-altered mesenchymal tumor or GLI1-altered soft tissue tumor serve as a nosological category, though the exact boundaries/criteria require further elucidation. We examined 16 tumors affecting predominantly adults (median age: 40 years), without sex predilection. Several patients
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Canadian Multicentric Pan-TRK (CANTRK) Immunohistochemistry Harmonization Study. Modern Pathol. (IF 7.5) Pub Date : 2023-11-14 Martin D Hyrcza,Sebastiao N Martins-Filho,Alan Spatz,Han-Jun Wang,Bibianna M Purgina,Patrice Desmeules,Paul C Park,Gilbert Bigras,Sungmi Jung,Jean-Claude Cutz,Zhaolin Xu,David M Berman,Brandon S Sheffield,Carol C Cheung,Charles Leduc,David M Hwang,Diana Ionescu,Paul Klonowski,Myriam Chevarie-Davis,Rose Chami,Bryan Lo,Tracy L Stockley,Ming-Sound Tsao,Emina Torlakovic
Tumor-agnostic testing for NTRK1-3 gene rearrangements is required to identify patients who may benefit from TRK inhibitor therapies. The overarching objective of this study was to establish a high-quality pan-TRK immunohistochemistry (IHC) screening assay among 18 large regional pathology laboratories across Canada using pan-TRK monoclonal antibody clone EPR17341 in a ring study design. TRK-fusion
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Synovial Sarcoma of the Gastrointestinal Tract. Modern Pathol. (IF 7.5) Pub Date : 2023-11-14 Domenika Ortiz Requena,Teri A Longacre,Andrew E Rosenberg,Jaylou M Velez Torres,Natalia Yanchenko,Monica T Garcia-Buitrago,Lysandra Voltaggio,Elizabeth A Montgomery
We report the clinicopathologic and immunohistochemical features of 18 cases of confirmed primary synovial sarcoma of the gastrointestinal tract. The neoplasms arose in 10 women and 8 men ranging in age from 23 to 81 years (mean: 50; median: 57.5 years). The tumors for which size was known ranged from 1.8 to 15.0 cm (mean: 5.2; median: 5.1 cm). Microscopically, 14 synovial sarcomas were of the monophasic
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Gradual transition towards anaplasia in Wilms tumor through tolerance to genetic damage. Modern Pathol. (IF 7.5) Pub Date : 2023-11-09 Kaname Uno,Bahar Rastegar,Caroline Jansson,Geoffroy Durand,Anders Valind,Subhayan Chattopadhyay,Alessia Bertolotti,Sara Ciceri,Filippo Spreafico,Paola Collini,Daniela Perotti,Linda Holmquist Mengelbier,David Gisselsson
Patients with Wilms tumor (WT) in general have excellent survival, but the prognosis of patients belonging to the subgroup of WT with diffuse anaplasia (DA) is poor due to frequent resistance to chemotherapy. We hypothesized that DA WT cells might undergo changes, such as acquiring a persistent tolerance to DNA damage and copy number aberrations (CNAs), that could eventually lead to their resistance
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Corrigendum to "HER2-Low Breast Cancer: Incidence, Clinicopathologic Features, and Survival Outcomes From Real-World Data of a Large Nationwide Cohort" [Modern Pathology 36(4) 100087]. Modern Pathol. (IF 7.5) Pub Date : 2023-11-09 Ximena Baez-Navarro,Mieke R van Bockstal,Eleni-Rosalina Andrinopoulou,Carolien H M van Deurzen
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Corrigendum to "Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship." [Modern Pathology 34 (2021) 2154-2167]. Modern Pathol. (IF 7.5) Pub Date : 2023-11-08 L Jeffrey Medeiros,Mario L Marques-Piubelli,Valentina F I Sangiorgio,Roberto Ruiz-Cordero,Francisco Vega,Andrew L Feldman,Jennifer R Chapman,Mark W Clemens,Kelly K Hunt,Mark G Evans,Christine Khoo,Stephen Lade,Mark Silberman,Jerzy Morkowski,Edward M Pina,Daniel C Mills,Christopher M Bates,Winston B Magno,Aliyah R Sohani,Beth A Sieling,Joseph M O'Donoghue,Chris M Bacon,Neill Patani,Despina Televantou
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The complexity of shapes; how the circularity of tumor nodules impacts prognosis in colorectal cancer. Modern Pathol. (IF 7.5) Pub Date : 2023-11-03 N P M Brouwer,A Khan,J M Bokhorst,F Ayatollahi,J Hay,F Ciompi,F Simmer,N Hugen,J H W de Wilt,M D Berger,A Lugli,I Zlobec,J Edwards,I D Nagtegaal
The current stratification of tumor nodules in colorectal cancer (CRC) staging is subjective and leads to high interobserver variability. In this study, objective assessment of the shape of lymph node metastases (LNMs), extranodal extension (ENE) and tumor deposits (TDs) was correlated with outcome. A test and validation cohort were included from two different institutions. The test cohort consisted
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Dedifferentiated and Undifferentiated Ovarian Carcinoma: An Aggressive and Molecularly Distinct Ovarian Tumor Characterized by Frequent SWI/SNF Complex Inactivation. Modern Pathol. (IF 7.5) Pub Date : 2023-11-03 Basile Tessier-Cloutier,Felix K F Kommoss,David L Kolin,Kristýna Němejcová,DuPreez Smith,Jennifer Pors,Colin J R Stewart,W Glenn McCluggage,William D Foulkes,Andreas von Deimling,Martin Köbel,Cheng-Han Lee
Dedifferentiated and undifferentiated ovarian carcinomas (DDOC/UDOC) are rare neoplasms defined by the presence of an undifferentiated carcinoma. In this study, we detailed the clinical, pathological, immunohistochemical, and molecular features of a series of DDOC/UDOC. We collected a multi-institutional cohort of 23 DDOC/UDOC and performed immunohistochemistry for core switch/sucrose nonfermentable
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Non-Lobular Invasive Breast Carcinomas with Bi-Allelic Pathogenic CDH1 Somatic Alterations: a Histologic, Immunophenotypic and Genomic Characterization. Modern Pathol. (IF 7.5) Pub Date : 2023-11-02 Fatemeh Derakhshan,Arnaud Da Cruz Paula,Pier Selenica,Edaise M da Silva,Anne Grabenstetter,Sahar Jalali,Andrea M Gazzo,Higinio Dopeso,Antonio Marra,David N Brown,Dara S Ross,Diana Mandelker,Pedram Razavi,Sarat Chandarlapaty,Hannah Y Wen,Edi Brogi,Hong Zhang,Britta Weigelt,Fresia Pareja,Jorge S Reis-Filho
CDH1 encodes for E-cadherin, and its loss of function is the hallmark of invasive lobular carcinoma (ILC). Albeit vanishingly rare, bi-allelic CDH1 alterations may be found in non-lobular breast carcinomas (NL-BCs). We sought to determine the clinicopathologic characteristics and repertoire of genetic alterations of NL-BCs harboring CDH1 bi-allelic genetic alterations. Analysis of 5,842 breast cancers
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Intestinal-Type Adenocarcinoma in Head and Neck: Dissecting Oncogenic Gene Alterations Through Whole Transcriptome and Exome Analysis. Modern Pathol. (IF 7.5) Pub Date : 2023-10-31 Diana Bell,Achim H Bell,Randal S Weber,Ehab Y Hanna
Adenocarcinomas of the nasal/paranasal sinuses are uncommon, but intestinal-type adenocarcinomas (ITACs) are important. Due to the rarity of these tumors, their molecular profile is not well known. To further investigate the molecular profile and find potential oncogenic drivers, we compared the whole transcriptome and exome of ITACs at different anatomic locations in the head and neck. Twenty-one
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Outcome-Based Risk Stratification Model for the Diagnosis of Placental Maternal Vascular Malperfusion. Modern Pathol. (IF 7.5) Pub Date : 2023-10-30 Dale L Davis,Adam C Lechner,David B Chapel,Jonathan C Slack,Chrystalle Katte Carreon,Bradley J Quade,Carlos Parra-Herran
The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to group a constellation of findings associated with impaired maternal-placental circulation. In isolation, these findings are relatively common in placentas from normal gestations, and there is uncertainty on how many, and which, are required. We aimed to determine the criteria essential for MVM diagnosis in
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Analysis of B7-H4 Expression Across Salivary Gland Carcinomas Reveals Adenoid Cystic Carcinoma-Specific Prognostic Relevance. Modern Pathol. (IF 7.5) Pub Date : 2023-10-28 Juliana Mota Siqueira,Yoshitsugu Mitani,Camilla Oliveira Hoff,Flavia Bonini,Luana Guimaraes de Sousa,Mario L Marques-Piubelli,Anurag Purushothaman,Mutsumi Mitani,Hui Dai,Shiaw-Yih Lin,Michael T Spiotto,Ehab Y Hanna,Daniel J McGrail,Adel K El-Naggar,Renata Ferrarotto
B7-H4 (VTCN1), a member of the B7 family, is overexpressed in several types of cancer. Here we investigated the pattern of expression of B7-H4 in salivary gland carcinomas (SGC) and assessed its potential as a prognostic marker and therapeutic target. Immunohistochemistry (IHC) analyses were performed in a cohort of 340 patient tumors, composed of 124 adenoid cystic carcinomas (ACC), 107 salivary duct
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Generative Adversarial Networks in Digital Histopathology: Current Applications, Limitations, Ethical Considerations, and Future Directions. Modern Pathol. (IF 7.5) Pub Date : 2023-10-27 Shahd A Alajaji,Zaid H Khoury,Mohamed Elgharib,Mamoon Saeed,Ahmed R H Ahmed,Mohammad B Khan,Tiffany Tavares,Maryam Jessri,Adam C Puche,Hamid Hoorfar,Ivan Stojanov,James J Sciubba,Ahmed S Sultan
Generative adversarial networks (GANs) have gained significant attention in the field of image synthesis, particularly in computer vision. GANs consist of a generative model and a discriminative model trained in an adversarial setting to generate realistic and novel data. In the context of image synthesis, the generator produces synthetic images, whereas the discriminator determines their authenticity
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Testicular Neoplasms With Sex Cord and Stromal Components Harbor a Recurrent Pattern of Chromosomal Gains. Modern Pathol. (IF 7.5) Pub Date : 2023-10-21 Andres M Acosta,Lynette M Sholl,Fiona Maclean,Chia-Sui Kao,Thomas M Ulbright
A small subset of testicular sex cord-stromal tumors, designated as Sertoli-stromal cell tumors (SSCTs), comprises a mixture of Sertoli, spindle, and/or Leydig cells. The clinicopathologic features of these tumors have not been studied in any detail, and their molecular features are unknown. We, therefore, assessed the morphologic and genomic features of 14 SSCTs, including 1 tumor with features similar
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Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms. Modern Pathol. (IF 7.5) Pub Date : 2023-10-21 Taito Itoh,Yuko Omori,Mitsuru Seino,Katsuya Hirose,Fumiko Date,Yusuke Ono,Yusuke Mizukami,Shuichi Aoki,Masaharu Ishida,Masamichi Mizuma,Takanori Morikawa,Ryota Higuchi,Goro Honda,Yasunobu Okamura,Kengo Kinoshita,Michiaki Unno,Toru Furukawa
Intraductal oncocytic papillary neoplasms (IOPNs) are distinct from intraductal papillary mucinous neoplasms based on characteristic morphologic and genetic features represented by fusion genes involving PRKACA or PRKACB (PRKACA/B). However, pancreatic and biliary tumors with partial oncocytic features are often encountered clinically, and their molecular features are yet to be clarified. This study
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Inflammatory Rhabdomyoblastic Tumor: Clinicopathologic and Molecular Analysis of 13 Cases. Modern Pathol. (IF 7.5) Pub Date : 2023-10-21 Toru Odate,Kaishi Satomi,Takashi Kubo,Yuko Matsushita,Toshihide Ueno,Akira Kurose,Kohei Shomori,Tokiko Nakai,Reiko Watanabe,Keiko Segawa,Shusa Ohshika,Naritomo Miyake,Sayaka Kudo,Tatsunori Shimoi,Eisuke Kobayashi,Motokiyo Komiyama,Seiichi Yoshimoto,Fumihiko Nakatani,Akira Kawai,Yasushi Yatabe,Shinji Kohsaka,Koichi Ichimura,Hitoshi Ichikawa,Akihiko Yoshida
Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. We investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The cohort included 7 men and 6 women, aged 23 to 80 years (median, 50 years), of whom 2 had neurofibromatosis type 1. Most tumors occurred in the deep soft tissues of the lower limbs, head/neck
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A New Hierarchy of Research Evidence for Tumor Pathology: A Delphi Study to Define Levels of Evidence in Tumor Pathology. Modern Pathol. (IF 7.5) Pub Date : 2023-10-20 Richard Colling,Iciar Indave,Javier Del Aguila,Ramon Cierco Jimenez,Fiona Campbell,Magdalena Chechlińska,Magdalena Kowalewska,Stefan Holdenrieder,Inga Trulson,Karolina Worf,Marina Pollán,Elena Plans-Beriso,Beatriz Pérez-Gómez,Oana Craciun,Ester García-Ovejero,Irmina Maria Michałek,Kateryna Maslova,Grzegorz Rymkiewicz,Joanna Didkowska,Puay Hoon Tan,Nur Diyana Md Nasir,Nickolas Myles,Gabrielle Goldman-Lévy
The hierarchy of evidence is a fundamental concept in evidence-based medicine, but existing models can be challenging to apply in laboratory-based health care disciplines, such as pathology, where the types of evidence and contexts are significantly different from interventional medicine. This project aimed to define a comprehensive and complementary framework of new levels of evidence for evaluating
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Utilization of p53 and p16 Immunohistochemistry in the Classification of Human Papillomavirus-Associated, p53 Wild-Type, and p53 Abnormal Oral Epithelial Dysplasia. Modern Pathol. (IF 7.5) Pub Date : 2023-10-19 Rachel Novack,Erin Chapman,Jiangyuan Gao,Basil Horst,Lynn N Hoang,Tony L Ng,Yen Chen Kevin Ko
p53 immunohistochemistry (IHC) has recently been shown to be a clinically useful marker for predicting risk of progression to invasive squamous cell carcinoma in oral epithelial dysplasia (OED). The literature supports the use of p53 IHC as a marker to identify TP53 mutation in in situ and invasive vulvar lesions and as a surrogate marker for high-risk human papillomavirus (HPV) infection, but there
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Pathologic Processing of Lung Cancer Resection Specimens After Neoadjuvant Therapy. Modern Pathol. (IF 7.5) Pub Date : 2023-10-14 Annikka Weissferdt,Cheuk H Leung,Heather Lin,Boris Sepesi,William N William,Stephen G Swisher,Tina Cascone,J Jack Lee,Abujiang Pataer
Neoadjuvant treatment of non-small cell lung cancer challenges the traditional processing of pathology specimens. Induction therapy before resection allows evaluation of the efficacy of neoadjuvant agents at the time of surgery. Many clinical trials use pathologic tumor response, measured as major pathologic response (MPR, ≤10% residual viable tumor [RVT]) or complete pathologic response (CPR, 0% RVT)
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Comprehensive Genomic and Transcriptomic Analysis of Sclerosing Pneumocytoma. Modern Pathol. (IF 7.5) Pub Date : 2023-10-14 Yi-Chen Yeh,Ping-Yuan Chu,Shin-Ying Lin,Shu-Ying Wang,Hsiang-Ling Ho,Yu-Chao Wang
Sclerosing pneumocytoma is a rare and distinct lung neoplasm whose histogenesis and molecular alterations are the subject of ongoing research. Our recent study revealed that AKT1 internal tandem duplications (ITD), point mutations, and short indels were present in almost all tested sclerosing pneumocytomas, suggesting that AKT1 mutations are a major driving oncogenic event in this tumor. Although the
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Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow. Modern Pathol. (IF 7.5) Pub Date : 2023-10-13 Sam Sadigh,Daniel J DeAngelo,Jacqueline S Garcia,Robert P Hasserjian,Christopher B Hergott,Andrew A Lane,Scott B Lovitch,Fabienne Lucas,Marlise R Luskin,Elizabeth A Morgan,Geraldine S Pinkus,Olga Pozdnyakova,Scott J Rodig,Vignesh Shanmugam,Harrison K Tsai,Eric S Winer,David Zemmour,Annette S Kim
In this study, we performed a comprehensive molecular analysis of paired skin and peripheral blood/bone marrow (BM) samples from 17 patients with cutaneous myeloid or cutaneous histiocytic-dendritic neoplasms. The cutaneous manifestations included 10 patients with cutaneous acute myeloid leukemia (c-AML), 2 patients with full or partial Langerhans cell differentiation, 2 patients with blastic plasmacytoid
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Portosinusoidal Vascular Disorder: A Heretofore Unrecognized Manifestation of Sickle Cell Disease? Modern Pathol. (IF 7.5) Pub Date : 2023-10-10 Pari Jafari,Gertruda Evaristo,Xiaotang Alison Du,Aarti E Sharma,Victoria Marcus,Xiuli Liu,Lei Zhao,Maria Westerhoff,John Hart
Portosinusoidal vascular disorder (PSVD) is a recently proposed histopathologic entity that encompasses a spectrum of often subtle hepatic microvascular lesions and related microarchitectural abnormalities. Clinical manifestations may arise years after histologic diagnosis and include extrahepatic portal vein thrombosis and portal hypertension. While the histopathologic features of PSVD have been associated
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The Clinicopathologic Features and Molecular Signatures of Blastoid High-Grade B Cell Lymphoma, Not Otherwise Specified. Modern Pathol. (IF 7.5) Pub Date : 2023-10-10 Lianqun Qiu,Pei Lin,Mahsa Khanlari,Jie Xu,Evan N Cohen,Sofia Garces,Roberto N Miranda,Wei Wang,Hong Fang,Carlos E Bueso-Ramos,L Jeffrey Medeiros,Shaoying Li
A small subset of high-grade B-cell lymphoma (HGBL) with blastoid morphology remains poorly understood. We assessed 55 cases of blastoid HGBL, not otherwise specified (NOS) and compared their clinicopathologic characteristics with those of 81 non-blastoid HGBL-NOS and 62 blastoid HGBL with MYC and BCL2, with or without BCL6 rearrangements (double/triple-hit lymphoma [D/THL]). Patients with blastoid
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Airway Injury Caused by Aspiration of Iron Sulfate Pills: A Series of Eleven Cases. Modern Pathol. (IF 7.5) Pub Date : 2023-09-26 Juan Xing,Ruchi Yadav,Prince Ntiamoah,Colin T Gillespie,Atul C Mehta,Daniel P Raymond,Sanjay Mukhopadhyay
It is not widely recognized that iron (ferrous sulfate) pill aspiration causes airway damage. Clinical diagnosis is challenging because patients are often unaware that they have aspirated a pill. The literature on this entity consists mainly of case reports. The aim of this study is to describe the clinical and pathologic features of iron pill aspiration in a series of 11 patients. A retrospective
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Pan-TRK Immunohistochemistry to Optimize the Detection of NTRK Fusions: Removing the Hay When Looking for the Needle. Modern Pathol. (IF 7.5) Pub Date : 2023-09-26 Esther Conde,Susana Hernandez,Marta Alonso,Fernando Lopez-Rios
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EWSR1::POU2AF3(COLCA2) Sarcoma: An Aggressive, Polyphenotypic Sarcoma With a Head and Neck Predilection. Modern Pathol. (IF 7.5) Pub Date : 2023-09-22 Olena Koshyk,Carina A Dehner,Mari F C M van den Hout,Isabelle Vanden Bempt,Raf Sciot,Hsuan-Ying Huang,Abbas Agaimy,Nasir Ud Din,Natálie Klubíčková,Elaheh Mosaieby,Alena Skálová,Květoslava Michalová,Patrick Schöffski,Andre M Oliveira,Kevin C Halling,Sounak Gupta,John M Gross,Johanna W M Nin,Michal Michal,Andrew L Folpe,Kemal Kosemehmetoglu,Jorge Torres-Mora,Michael Michal
EWSR1::POU2AF3 (COLCA2) sarcomas are a recently identified group of undifferentiated round/spindle cell neoplasms with a predilection for the head and neck region. Herein, we report our experience with 8 cases, occurring in 5 men and 3 women (age range, 37-74 years; median, 60 years). Tumors involved the head/neck (4 cases), and one each the thigh, thoracic wall, fibula, and lung. Seven patients received