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Insular cortex stimulation alleviates neuropathic pain through changes in the expression of collapsin response mediator protein 2 involved in synaptic plasticity Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-11 Kyeongmin Kim, Guanghai Nan, Hyeji Bak, Hee Young Kim, Junesun Kim, Myeounghoon Cha, Bae Hwan Lee
In recent studies, brain stimulation has shown promising potential to alleviate chronic pain. Although studies have shown that stimulation of pain-related brain regions can induce pain-relieving effects, few studies have elucidated the mechanisms of brain stimulation in the insular cortex (IC). The present study was conducted to explore the changes in characteristic molecules involved in pain modulation
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Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-09 Zongyi Liang, Liren Li, Liying Bai, Yan Gao, Yiming Qiao, Xueli Wang, Lili Yv, Ji-Tian Xu
Emerging evidence has implicated an important role of synapse-associated protein-97 (SAP97)-regulated GluA1-containing AMPARs membrane trafficking in cocaine restate and in contextual episodic memory of schizophrenia. Herein, we investigated the role of SAP97 in neuropathic pain following lumbar 5 spinal nerve transection (SNT) in rats. Our results showed that SNT led to upregulation of SAP97, enhanced
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Cathepsin B as a key regulator of ferroptosis in microglia following intracerebral hemorrhage Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-08 Jinxin Lu, Haiying Li, Zhengquan Yu, Chang Cao, Zhongmou Xu, Lu Peng, John H. Zhang, Gang Chen
Intracerebral hemorrhage (ICH) is a subtype of stroke marked by elevated mortality and disability rates. Recently, mounting evidence suggests a significant role of ferroptosis in the pathogenesis of ICH. Through a combination of bioinformatics analysis and basic experiments, our goal is to identify the primary cell types and key molecules implicated in ferroptosis post-ICH. This aims to propel the
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Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-07 Karen Ka Yan Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Cristo
Children who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition
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Charcot-Marie-tooth disease type 2A: An update on pathogenesis and therapeutic perspectives Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-05 Claudia Alberti, Federica Rizzo, Alessia Anastasia, Giacomo Comi, Stefania Corti, Elena Abati
Mutations in the gene encoding MFN2 have been identified as associated with Charcot–Marie–Tooth disease type 2A (CMT2A), a neurological disorder characterized by a broad clinical phenotype involving the entire nervous system. MFN2, a dynamin-like GTPase protein located on the outer mitochondrial membrane, is well-known for its involvement in mitochondrial fusion. Numerous studies have demonstrated
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Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer's disease and mild cognitive impairment Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-05 Kazuo Yamashiro, Kaito Takabayashi, Koji Kamagata, Yuichiro Nishimoto, Yuka Togashi, Yohsuke Yamauchi, Kotaro Ogaki, Yuanzhe Li, Taku Hatano, Yumiko Motoi, Michimasa Suzuki, Koichi Miyakawa, Dai Ishikawa, Shigeki Aoki, Takao Urabe, Nobutaka Hattori
Neuroinflammation contributes to the pathology and progression of Alzheimer's disease (AD), and it can be observed even with mild cognitive impairment (MCI), a prodromal phase of AD. Free water (FW) imaging estimates the extracellular water content and has been used to study neuroinflammation across several neurological diseases including AD. Recently, the role of gut microbiota has been implicated
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Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-03 Susanne Knorr, Lisa Rauschenberger, Muthuraman Muthuraman, Rhonda McFleder, Thomas Ott, Kathrin Grundmann-Hauser, Takahiro Higuchi, Jens Volkmann, Chi Wang Ip
DYT-TOR1A (DYT1) dystonia, characterized by reduced penetrance and suspected environmental triggers, is explored using a “second hit” DYT-TOR1A rat model. We aim to investigate the biological mechanisms driving the conversion into a dystonic phenotype, focusing on the striatum's role in dystonia pathophysiology.
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T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-02 Junjian Zeng, Zhiqiang Liao, Hanqin Yang, Qiong Wang, Zhiyong Wu, Fuzhou Hua, Zhidong Zhou
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological features of β-amyloid (Aβ) and hyperphosphorylated tau protein accumulation in the brain, often accompanied by cognitive decline. So far, our understanding of the extent and role of adaptive immune responses in AD has been quite limited. T cells, as essential members of the adaptive immune system, exhibit quantitative
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Influence of the gut microbiome on appetite-regulating neuropeptides in the hypothalamus: Insight from conventional, antibiotic-treated, and germ-free mouse models of anorexia nervosa Neurobiol. Dis. (IF 6.1) Pub Date : 2024-03-01 Radka Roubalová, Petra Procházková, Tereza Kovářová, Janet Ježková, Tomáš Hrnčíř, Helena Tlaskalová-Hogenová, Hana Papežová
Recent research highlights the profound impact of the gut microbiome on neuropsychiatric disorders, shedding light on its potential role in shaping human behavior. In this study, we investigate the role of the gut microbiome in appetite regulation using activity-based anorexia (ABA) mouse model of anorexia nervosa (AN) — a severe eating disorder with significant health consequences. ABA was induced
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Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-28 Lu Deng, Hong Jiang, Jingjing Lin, Di Xu, Ailin Qi, Qing Guo, Ping-Ping Li, Xinshi Wang, Judy S. Liu, Xiaoqin Fu, Peijun Li
Epilepsy is a brain disorder affecting up to 1 in 26 individuals. Despite its clinical importance, the molecular mechanisms of epileptogenesis are still far from clarified. Our previous study showed that disruption of in excitatory neurons alters cortical circuits and leads to generation of focal epilepsy. In this study, a mouse line with conditional gene knockout in inhibitory neurons was established
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Alteration of gut microbiota in post-stroke depression patients with Helicobacter pylori infection Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-28 Mei Sun, Han Chen, Siyu Dong, Guoxin Zhang, Xiaoying Zhou, Hong Cheng
Background: Several studies have identified an association between the gut microbiome and post-stroke depression(PSD), and () infection cause significant alterations in the composition of the gastrointestinal microbiome. However, evidence regarding the role of the infection in promoting PSD is still lacking. Here, we conducted a retrospective study to explore risk factors associated with PSD.
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Blood and cerebellar abundance of ATXN3 splice variants in spinocerebellar ataxia type 3/Machado-Joseph disease Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-27 Mafalda Raposo, Jeannette Hübener-Schmid, Rebecca Tagett, Ana F. Ferreira, Ana Rosa Vieira Melo, João Vasconcelos, Paula Pires, Teresa Kay, Hector Garcia-Moreno, Paola Giunti, Magda M. Santana, Luis Pereira de Almeida, Jon Infante, Bart P. van de Warrenburg, Jeroen J. de Vries, Jennifer Faber, Thomas Klockgether, Nicolas Casadei, Jakob Admard, Ludger Schöls, Olaf Riess, European Spinocerebellar ataxia
Spinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD) is a heritable proteinopathy disorder, whose causative gene, , undergoes alternative splicing. Ataxin-3 protein isoforms differ in their toxicity, suggesting that certain splice variants may be crucial in driving the selective toxicity in SCA3. Using RNA-seq datasets we identified and determined the abundance of annotated transcripts
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The free plasma amyloid Aβ1–42/Aβ1–40 ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma Aβ1–42/Aβ1–40 ratio. The BALTAZAR study Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-27 S. Schraen-Maschke, A. Duhamel, J.S. Vidal, N. Ramdane, L. Vaudran, C. Dussart, L. Buée, B. Sablonnière, C. Delaby, B. Allinquant, A. Gabelle, S. Bombois, S. Lehmann, O. Hanon
Blood-based biomarkers are a non-invasive solution to predict the risk of conversion of mild cognitive impairment (MCI) to dementia. The utility of free plasma amyloid peptides (not bound to plasma proteins and/or cells) as an early indicator of conversion to dementia is still debated, as the results of studies have been contradictory. In this context, we investigated whether plasma levels of the free
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hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-24 Sophia Dithmar, Abdolhossein Zare, Saeede Salehi, Michael Briese, Michael Sendtner
Axonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis. The RNA-binding protein hnRNP R interacts with different motoneuron disease-related proteins such as SMN and TDP-43 and has important roles in axons of motoneurons, including axonal mRNA transport. However, whether hnRNP R also modulates axonal
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Structural interhemispheric connectivity defects in mouse models of BBSOAS: Insights from high spatial resolution 3D white matter tractography Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-24 Jean Christophe Deloulme, Maxime Leclercq, Olivier Deschaux, Gemma Flore, Laetitia Capellano, Chiara Tocco, Barbara Yael Braz, Michèle Studer, Hana Lahrech
White matter (WM) tract formation and axonal pathfinding are major processes in brain development allowing to establish precise connections between targeted structures. Disruptions in axon pathfinding and connectivity impairments will lead to neural circuitry abnormalities, often associated with various neurodevelopmental disorders (NDDs). Among several neuroimaging methodologies, Diffusion Tensor
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Gene-environment interaction elicits dystonia-like features and impaired translational regulation in a DYT-TOR1A mouse model Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-24 Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Rauschenberger, Muthuraman Muthuraman, Panagiota Arampatzi, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip
DYT-TOR1A dystonia is the most common monogenic dystonia characterized by involuntary muscle contractions and lack of therapeutic options. Despite some insights into its etiology, the disease's pathophysiology remains unclear. The reduced penetrance of about 30% suggests that extragenetic factors are needed to develop a dystonic phenotype. In order to systematically investigate this hypothesis, we
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Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-23 Yu-Ting Huang, Ya-Wen Chen, Tze-Yen Lin, Jin-Chung Chen
A common adverse effect of Parkinson's disease (PD) treatment is L-dopa-induced dyskinesia (LID). This condition results from both dopamine (DA)-dependent and DA-independent mechanisms, as glutamate inputs from corticostriatal projection neurons impact DA-responsive medium spiny neurons in the striatum to cause the dyskinetic behaviors. In this study, we explored whether suppression of presynaptic
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Role of soluble epoxide hydrolase in pain and depression comorbidity Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-21 Yuchen Bu, Siqi Yang, Di Wang, Suwan Hu, Qi Zhang, Zifeng Wu, Chun Yang
The coexistence of chronic pain and depression in clinical practice places a substantial social burden and profoundly impacts in patients. Although a clear correlation exists, the underlying mechanism of comorbidity between chronic pain and depression remains elusive. Research conducted in recent decades has uncovered that soluble epoxide hydrolase, a pivotal enzyme in the metabolism of polyunsaturated
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The potential roles of salivary biomarkers in neurodegenerative diseases Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-19 Ling-Ling Jiao, Hui-Lin Dong, Meng-Meng Liu, Peng-Lin Wu, Yi Cao, Yuan Zhang, Fu-Gao Gao, Huai-Yuan Zhu
Current research efforts on neurodegenerative diseases are focused on identifying novel and reliable biomarkers for early diagnosis and insight into disease progression. Salivary analysis is gaining increasing interest as a promising source of biomarkers and matrices for measuring neurodegenerative diseases. Saliva collection offers multiple advantages over the currently detected biofluids as it is
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Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-18 Vaishnavi S. Jadhav, Jade G. Stair, Randall J. Eck, Samuel N. Smukowski, Heather N. Currey, Laura Garcia Toscano, Joshua C. Hincks, Caitlin S. Latimer, Paul N. Valdmanis, Brian C. Kraemer, Nicole F. Liachko
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the protein TDP-43 as a secondary pathology. The presence of TDP-43 pathology in AD is associated with increased tau neuropathology and worsened clinical outcomes
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Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-16 Jie Liu, Qian Dai, Tong Qu, Jun Ma, Chaolan Lv, Haitao Wang, Yue Yu
Limited treatment options have been shown to alter the natural course of constipation-predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective approaches are urgently needed. We investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in a mouse model of IBS-C. In the current study, C57BL/6 mice were randomly divided into normal control, IBS-C model
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TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43 Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-15 Juan M. Godoy-Corchuelo, Zeinab Ali, Jose M. Brito Armas, Aurea B. Martins-Bach, Irene García-Toledo, Luis C. Fernández-Beltrán, Juan I. López-Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jimenez-Coca, Ramón A. Muñoz de Bustillo Alfaro, Maria J. Sánchez-Barrena, Remya R. Nair, Brian J. Nieman, Jason P. Lerch, Karla L. Miller, Hande P. Ozdinler, Elizabeth M.C. Fisher, Thomas J. Cunningham, Abraham
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as “TDP-43 proteinopathies”. Aggregates of TDP-43 are present in the brains and spinal cords of >97% of amyotrophic lateral sclerosis (ALS), and in brains of ∼50% of frontotemporal dementia (FTD) patients. While mutations in the TDP-43 gene () are usually associated with ALS, many clinical reports have linked
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Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-15 Nicholas Vidas-Guscic, Joëlle van Rijswijk, Johan Van Audekerke, Ben Jeurissen, Israel Nnah, Haiying Tang, Ignacio Munoz-Sanjuan, Dorian Pustina, Roger Cachope, Annemie Van der Linden, Daniele Bertoglio, Marleen Verhoye
Huntington's disease (HD) is a progressive neurodegenerative disease affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans and animal models of HD. The identification of sensitive white-matter-based biomarkers in HD animal models will be important in understanding disease mechanisms and testing the efficacy of therapeutic interventions. Here
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Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-15 Claudia Tato-Fernández, Laura L. Ekblad, Elina Pietilä, Virva Saunavaara, Semi Helin, Riitta Parkkola, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne, Anniina Snellman
Except for aging, carrying the allele () is the most important risk factor for sporadic Alzheimer's disease. carriers may have reduced capacity to recycle lipids, resulting in white matter microstructural abnormalities. In this study, we evaluated whether white matter impairment measured by diffusion tensor imaging (DTI) differs between healthy individuals with a different number of alleles, and whether
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Navigating the future of retinitis pigmentosa treatments: A comprehensive analysis of therapeutic approaches in rd10 mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-08 Hongli Yang, Hui Zhang, Xiaorong Li
Retinitis pigmentosa (RP) is a degenerative disease, caused by genetic mutations that lead to a loss in photoreceptors. For research on RP, rd10 mice, which carry mutations in the phosphodiesterase (PDE) gene, exhibit degenerative patterns comparable to those of patients with RP, making them an ideal model for investigating potential treatments. Although numerous studies have reported the potential
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NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1 Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-08 Qi He, Changchang Meng, Mengjie Jia, Junyi Tan, Keli Huang, Hui Gan, Lingyu Li, Jing Zhao
Innate inflammation is crucial for ischemic stroke development. NLRP6, a nucleotide-binding and oligomerization domain-like receptors (NLRs) family member, regulates innate inflammation. Whether NLRP6 regulates neurological damage and neuroinflammation during ischemic stroke remains unclear. We report that NLRP6 is abundantly expressed in microglia and significantly upregulated in the ischemic brain
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Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-07 Sultan Aljuraysi, Mark Platt, Michela Pulix, Harish Poptani, Antonius Plagge
Mutations of the human () cause a neurodevelopmental disorder characterised by microcephaly and intellectual disability. Trappc9 constitutes a subunit specific to the intracellular membrane-associated TrappII complex. The TrappII complex interacts with Rab11 and Rab18, the latter being specifically associated with lipid droplets (LDs). Here we used non-invasive imaging to characterise knock-out (KO)
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The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-07 Yu Cai, Yangqiqi Zhang, Shuo Leng, Yuanyuan Ma, Quan Jiang, Qiuting Wen, Shenghong Ju, Jiani Hu
The term “glymphatic” emerged roughly a decade ago, marking a pivotal point in neuroscience research. The glymphatic system, a glial-dependent perivascular network distributed throughout the brain, has since become a focal point of investigation. There is increasing evidence suggesting that impairment of the glymphatic system appears to be a common feature of neurodegenerative disorders, and this impairment
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Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-07 Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B. Relvas, Ana M. Sebastião, Sandra H. Vaz
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition, closely linked to the loss/gain of astrocytic function. Using the ALS SOD1 mice, we investigated the astrocytic contribution for the electrophysiological
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Depression-like phenotypes in mice following common bile duct ligation: Insights into the gut–liver–brain axis via the vagus nerve Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-07 Yong Yang, Akifumi Eguchi, Chisato Mori, Kenji Hashimoto
Depression frequently occurs in patients with liver cirrhosis, yet the reasons for this correlation are not fully understood. Dysbiosis of gut microbiota has been implicated in depression through the gut–brain axis via the vagus nerve. This study explored the potential role of the gut–liver–brain axis via the vagus nerve in depression-like phenotypes in mice with liver cirrhosis. These mice underwent
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P2X7 receptor of olfactory bulb microglia plays a pathogenic role in stress-related depression in mice with allergic rhinitis Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-06 Yakui Mou, Caiyu Sun, Shizhuang Wei, Xiaoyu Song, Hanrui Wang, Yao Wang, Chao Ren, Xicheng Song
The aim of this study was to explore the role and mechanism of the olfactory bulb (OB) microglial P2X7 receptor (P2X7R) in allergic rhinitis (AR)-related depression, with the objective of identifying a potential clinical target. An AR mouse model was induced using ovalbumin (OVA), while chronic stress was employed to induce depression. The study used P2X7R-specific antagonists and OB microglia-specific
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Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-06 Eva P. Cuevas, Loreto Martinez-Gonzalez, Clara Gordillo, Carlota Tosat-Bitrián, Carmen Pérez de la Lastra, Amets Sáenz, Carmen Gil, Valle Palomo, Ángeles Martin-Requero, Ana Martinez
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Astrocyte-derived lactate in stress disorders Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-29 Farah Chamaa, Pierre J. Magistretti, Hubert Fiumelli
Stress disorders are psychiatric disorders arising following stressful or traumatic events. They could deleteriously affect an individual's health because they often co-occur with mental illnesses. Considerable attention has been focused on neurons when considering the neurobiology of stress disorders. However, like other mental health conditions, recent studies have highlighted the importance of astrocytes
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Altered static and dynamic functional connectivity of the default mode network across epilepsy subtypes in children: A resting-state fMRI study Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-29 Yongxin Li, Yun Ran, Maohua Yao, Qian Chen
Background Epilepsy is a chronic neurologic disorder characterized by abnormal functioning of brain networks, making it a complex research topic. Recent advancements in neuroimaging technology offer an effective approach to unraveling the intricacies of the human brain. Within different types of epilepsy, there is growing recognition regarding ongoing changes in the default mode network (DMN). However
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The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-02 Dani M. Long, Olga Cravetchi, Eileen S. Chow, Charles Allen, Doris Kretzschmar
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TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-02 Nan Xu, Yufeng He, Chunyu Zhang, Yongqiang Zhang, Shengjie Cheng, Li Deng, Yi Zhong, Bin Liao, Yan Wei, Jian Feng
The heart and brain are the core organs of the circulation and central nervous system, respectively, and play an important role in maintaining normal physiological functions. Early neuronal and cardiac damage affects organ function. The relationship between the heart and brain is being continuously investigated. Evidence-based medicine has revealed the concept of the “heart- brain axis,” which may
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Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-28 Dick Jaarsma, Maria B. Birkisdóttir, Randy van Vossen, Demi W.G.D. Oomen, Oussama Akhiyat, Wilbert P. Vermeij, Sebastiaan K.E. Koekkoek, Chris I. De Zeeuw, Laurens W.J. Bosman
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A systematic review and meta-analysis of tau phosphorylation in mouse models of familial Alzheimer's disease Neurobiol. Dis. (IF 6.1) Pub Date : 2024-02-01 Malamati Kourti, Athanasios Metaxas
Transgenic models of familial Alzheimer's disease (AD) serve as valuable tools for probing the molecular mechanisms associated with amyloid-beta (Aβ)-induced pathology. In this meta-analysis, we sought to evaluate levels of phosphorylated tau (p-tau) and explore potential age-related variations in tau hyperphosphorylation, within mouse models of AD. The PubMed and Scopus databases were searched for
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Trimethylamine-N-oxide and cerebral stroke risk: A review Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-28 Phurbu Dolkar, Tenzin Deyang, Nikhilesh Anand, Annan Gopinath Rathipriya, Tousif Ahmed Hediyal, Vichitra Chandrasekaran, Naveen Kumar Krishnamoorthy, Vasavi Rakesh Gorantla, Muhammed Bishir, Luay Rashan, Sulie L. Chang, Meena Kishore Sakharkar, Jian Yang, Saravana Babu Chidambaram
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Cyclin F can alter the turnover of TDP-43 Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-28 Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee
Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43. A hurdle to the use of cyclin F, however, is that the overexpression of cyclin F can lead to the initiation of cell death pathways. Accordingly, the aim of this study was to identify and evaluate a less
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Low-frequency stimulation in the zona incerta attenuates seizure via driving GABAergic neuronal activity Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-28 Mengdi Zhang, Lin Yang, Zhongxia Li, Fan Fei, Yuan Zhou, Dongxiao Jiang, Yuyi Zheng, Hui Cheng, Yu Wang, Cenglin Xu, Jiajia Fang, Shuang Wang, Zhong Chen, Yi Wang
Background Managing refractory epilepsy presents a significant a substantial clinical challenge. Deep brain stimulation (DBS) has emerged as a promising avenue for addressing refractory epilepsy. However, the optimal stimulation targets and effective parameters of DBS to reduce seizures remian unidentified. Objectives This study endeavors to scrutinize the therapeutic potential of DBS within the zona
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Blood D-serine levels correlate with aging and dopaminergic treatment in Parkinson's disease Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-20 Alberto Imarisio, Isar Yahyavi, Micol Avenali, Anna Di Maio, Gabriele Buongarzone, Caterina Galandra, Marta Picascia, Asia Filosa, Clara Gasparri, Maria Cristina Monti, Mariangela Rondanelli, Claudio Pacchetti, Francesco Errico, Enza Maria Valente, Alessandro Usiello
We recently described increased D- and L-serine concentrations in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, the post-mortem caudate-putamen of human Parkinson's disease (PD) brains and the cerebrospinal fluid (CSF) of de novo living PD patients. However, data regarding blood D- and L-serine levels in PD are scarce. Here, we investigated whether the serum profile
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The gut-brain axis: Correlation of choroid plexus volume and permeability with inflammatory biomarkers in Crohn's disease Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-23 Cristiana Bonifacio, Giovanni Savini, Christian Reca, Federico Garoli, Riccardo Levi, Giulia Vatteroni, Luca Balzarini, Mariangela Allocca, Federica Furfaro, Arianna Dal Buono, Alessandro Armuzzi, Silvio Danese, Michela Matteoli, Maria Rescigno, Gionata Fiorino, Letterio S. Politi
Background The dysregulation of the gut-brain axis in chronic inflammatory bowel diseases can cause neuro-psychological disturbances, but the underlying mechanisms are still not fully understood. The choroid plexus (CP) maintains brain homeostasis and nourishment through the secretion and clearance of cerebrospinal fluid. Recent research has demonstrated the existence of a CP vascular barrier in mice
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Pathologic correlates of aging-related tau astrogliopathy: ARTAG is associated with LATE-NC and cerebrovascular pathologies, but not with ADNC Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-19 Yuriko Katsumata, Xian Wu, Khine Zin Aung, Kathryn Gauthreaux, Charles Mock, Shelley L. Forrest, Gabor G. Kovacs, Peter T. Nelson
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Exo-miR-144-3p as a promising diagnostic biomarker for depressive symptoms in heart failure Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-22 Ruting Wang, Kai Huang, Yuehua Feng, Jiahao Duan, Hangfeng Ying, Qianyuan Shi, Yi Zhang, Riyue Jiang, Ling Yang
Aims The prevalence of depression is higher in heart failure (HF) patients. Early screening of depressive symptoms in HF patients and timely intervention can help to improve patients' quality of life and prognosis. This study aims to explore diagnostic biomarkers by examining the expression profile of serum exosomal miRNAs in HF patients with depressive symptoms. Methods Serum exosomal RNA was isolated
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PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-21 Issa O. Yusuf, Sepideh Parsi, Lyle W. Ostrow, Robert H. Brown, Paul R. Thompson, Zuoshang Xu
Alteration in protein citrullination (PC), a common posttranslational modification (PTM), contributes to pathogenesis in various inflammatory disorders. We previously reported that PC and protein arginine deiminase 2 (PAD2), the predominant enzyme isoform that catalyzes this PTM in the central nervous system (CNS), are altered in mouse models of amyotrophic lateral sclerosis (ALS). We now demonstrate
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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-14 Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell, Matthew J. Benskey
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Corrigendum to “ Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy Body Disease” [Neurobiology of Disease127 (2019) 163–177] Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-12 Brian Spencer, Ivy Trinh, Edward Rockenstein, Michael Mante, Jazmin Florio, Anthony Adame, Omar M.A. El-Agnaf, Changyoun Kim, Eliezer Masliah, Robert A. Rissman
Abstract not available
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Widespread slow oscillations support interictal epileptiform discharge networks in focal epilepsy Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-12 Hongyi Ye, Lingqi Ye, Lingli Hu, Yuyu Yang, Yi Ge, Ruotong Chen, Shan Wang, Bo Jin, Wenjie Ming, Zhongjin Wang, Sha Xu, Cenglin Xu, Yi Wang, Yao Ding, Junming Zhu, Meiping Ding, Zhong Chen, Shuang Wang, Cong Chen
Interictal epileptiform discharges (IEDs) often co-occur across spatially-separated cortical regions, forming IED networks. However, the factors prompting IED propagation remain unelucidated. We hypothesized that slow oscillations (SOs) might facilitate IED propagation. Here, the amplitude and phase synchronization of SOs preceding propagating and non-propagating IEDs were compared in 22 patients with
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Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-12 Mariia Ivanova, Irina Belaya, Nina Kucháriková, Izaque de Sousa Maciel, Liudmila Saveleva, Arto Alatalo, Ilona Juvonen, Navjot Thind, Clarisse Andrès, Riikka Lampinen, Sweelin Chew, Katja M. Kanninen
Integrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known to participate in multiple cellular processes such as adhesion, migration, and signaling, its specific role in AD remains poorly understood, particularly in astrocytes, the main glial cell type in the brain
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Spontaneous and optogenetically induced cortical spreading depolarization in familial hemiplegic migraine type 1 mutant mice Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-09 Inge C.M. Loonen, Rob A. Voskuyl, Maarten Schenke, Sandra H. van Heiningen, Arn M.J.M. van den Maagdenberg, Else A. Tolner
Mechanisms underlying the migraine aura are incompletely understood, which to large extent is related to a lack of models in which cortical spreading depolarization (CSD), the correlate of the aura, occurs spontaneously. Here, we investigated electrophysiological and behavioural CSD features in freely behaving mice expressing mutant CaV2.1 Ca2+ channels, either with the milder R192Q or the severer
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TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-09 Charlene P. Poore, Nurul A.M.N. Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Liao
Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagonists have been examined for their efficacy in mitigating excitotoxicity, but failed to generate beneficial outcome due to their side effects on healthy
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Synaptic Zn2+ contributes to deleterious consequences of spreading depolarizations Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-09 Michael C. Bennett, Katelyn M. Reinhart, Jordan E. Weisend, Russell A. Morton, Andrew P. Carlson, C. William Shuttleworth
Spreading depolarizations (SDs) are profound waves of neuroglial depolarization that can propagate repetitively through injured brain. Recent clinical work has established SD as an important contributor to expansion of acute brain injuries and have begun to extend SD studies into other neurological disorders. A critical challenge is to determine how to selectively prevent deleterious consequences of
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Interhemispheric reactivity of the subthalamic nucleus sustains progressive dopamine neuron loss in asymmetrical parkinsonism Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-03 Pascal Salin, Christophe Melon, Carine Chassain, Paolo Gubellini, Guilhem Pages, Bruno Pereira, Yann Le Fur, Franck Durif, Lydia Kerkerian-Le Goff
Parkinson's disease (PD) is characterized by the progressive and asymmetrical degeneration of the nigrostriatal dopamine neurons and the unilateral presentation of the motor symptoms at onset, contralateral to the most impaired hemisphere. We previously developed a rat PD model that mimics these typical features, based on unilateral injection of a substrate inhibitor of excitatory amino acid transporters
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Neurovascular coupling alteration in drug-naïve Parkinson's disease: The underlying molecular mechanisms and levodopa's restoration effects Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-08 Chenqing Wu, Haoting Wu, Cheng Zhou, Xiaojun Guan, Tao Guo, Jingjing Wu, Jingwen Chen, Jiaqi Wen, Jianmei Qin, Sijia Tan, Xiaojie Duanmu, Weijin Yuan, Qianshi Zheng, Baorong Zhang, Xiaojun Xu, Minming Zhang
Background Parkinson's disease (PD) patients exhibit an imbalance between neuronal activity and perfusion, referred to as abnormal neurovascular coupling (NVC). Nevertheless, the underlying molecular mechanism and how levodopa, the standard treatment in PD, regulates NVC is largely unknown. Material and methods A total of 52 drug-naïve PD patients and 49 normal controls (NCs) were enrolled. NVC was
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Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-03 Ilham El Atiallah, Giulia Ponterio, Maria Meringolo, Giuseppina Martella, Giuseppe Sciamanna, Annalisa Tassone, Martina Montanari, Maria Mancini, Antonio N. Castagno, Libo Yu-Taeger, Hoa Huu Phuc Nguyen, Paola Bonsi, Antonio Pisani
Loss-of-function mutations in the GNAL gene are responsible for DYT-GNAL dystonia. However, how GNAL mutations contribute to synaptic dysfunction is still unclear. The GNAL gene encodes the Gαolf protein, an isoform of stimulatory Gαs enriched in the striatum, with a key role in the regulation of cAMP signaling. Here, we used a combined biochemical and electrophysiological approach to study GPCR-mediated
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Scaling of smaller pyramidal neuron size and lower energy production in schizophrenia Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-02 Kirsten E. Schoonover, Nora E. Miller, Kenneth N. Fish, David A. Lewis
Background Dorsolateral prefrontal cortex (DLPFC) dysfunction in schizophrenia appears to reflect alterations in layer 3 pyramidal neurons (L3PNs), including smaller cell bodies and lower expression of mitochondrial energy production genes. However, prior somal size studies used biased strategies for identifying L3PNs, and somal size and levels of energy production markers have not been assessed in
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Inferior social hierarchy is vulnerable to anxiety-like behavior in chronic pain mice: Potential role of gut microbiota and metabolites Neurobiol. Dis. (IF 6.1) Pub Date : 2024-01-04 Yuanyuan Wang, Xinying Zhang, Yiting Yao, Suwan Hu, Wenli Wang, Di Wang, Chaoli Huang, Hanyu Liu, Qi Zhang, Teng He, Sen Wang, Zifeng Wu, Riyue Jiang, Chun Yang
Social dominance is a universal phenomenon among grouped animals that profoundly affects survival, health, and reproductive success by determining access to resources, and exerting a powerful influence on subsequent behavior. However, the understanding of pain and anxiety comorbidities in dominant or subordinate animals suffering from chronic pain is not well-defined. Here, we provide evidence that
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