-
Prevention of sarcopenia in patients with obesity after bariatric and metabolic surgery: the effect of programmed training on the muscle tissue and anthropometric functions - a randomized controlled trial (SarxOb study protocol). Biomol. Biomed. (IF 3.4) Pub Date : 2022-09-25 Marek Bužga, Matej Pekar, Jaroslav Uchytil, Veronika Horká, Jan Malůš, Dominik Vilímek, Zdeněk Švagera, Petr Kutáč, Pavol Holéczy
Obesity is a serious metabolic disease that significantly increases cardiovascular risks and other health complications. Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from obesity that increases the health risks and is associated with cardiac, respiratory and other diseases. Bariatric and metabolic surgery (BMS) leads to significant changes in body composition
-
Amphiregulin/epidermal growth factor receptor/hypoxia-inducible factor-1α pathway regulates T helper 9 and T cytotoxic 9 cell response in adult patients with infectious mononucleosis. Biomol. Biomed. (IF 3.4) Pub Date : 2022-09-22 Yu Li, Lan Li, Weihua Zhang, Ying Gao
Amphiregulin (AREG)/epidermal growth factor receptor (EGFR) signaling induces hypoxia-inducible factor-1α (HIF-1α), leading to promotion of T helper 9 (Th9) differentiation and anti-tumor functions. However, the role of the AREG/EGFR/HIF-1α pathway in regulating interleukin-9 (IL-9) production by T cells in adult patients with infectious mononucleosis (IM) has not been fully elucidated. Fifty IM patients
-
Analysis of cardiac manifestation and treatment of multisystem inflammatory syndrome in children related to SARS-CoV-2. Biomol. Biomed. (IF 3.4) Pub Date : 2022-09-18 Stasa Krasic, Sanja Ninic, Sergej Prijic, Sasa Popovic, Srdjan Pasic, Gordana Petrovic, Boris Zec, Snezana Ristic, Dejan Nesic, Luka Nikolic, Vladislav Vukomanovic
Cardiovascular manifestations are common (35-100%) in the multisystem inflammatory syndrome in children. Our study aimed to analyze treatment impact and cardiovascular involvement in patients with multisystem inflammatory syndrome in children. The retrospective cohort included 81 patients treated between April 2020 and December 2021 (9.3±4.6 years). Elevated cardiac troponin I and pro-B-type natriuretic
-
SARS-CoV-2 infection and multi-organ system damage: a review. Biomol. Biomed. (IF 3.4) Pub Date : 2022-09-16 Ali A Rabaan, Samira Smajlović, Huseyin Tombuloglu, Sabahudin Ćordić, Azra Hajdarević, Nudžejma Kudić, Abbas Al Mutai, Safaa A Turkistani, Shamsah H Al-Ahmed, Nisreen A Al-Zaki, Mona J Al Marshood, Amal H Alfaraj, Saad Alhumaid, Ebtesam Al-Suhaimi
The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred million people globally as of August 2022. Organs and cells harboring angiotensin-converting enzyme 2 (ACE2) surface receptors are the primary targets of the virus. However, once it enters the body through the respiratory system, the virus can spread hematogenously to infect other body organs. Therefore, COVID-19
-
Clinical features and outcomes of fusion gene defined adult Ph-negative B-cell precursor acute lymphoblastic leukemia patients: a single institutional report. Biomol. Biomed. (IF 3.4) Pub Date : 2022-09-14 Kai Sun, Jun Wang, Wen-Min Chen, Nan Xu, Ling-Yu Long, Xu Wang, Hao Jiang, Qian Jiang, Xiao-Jun Huang, Ya-Zhen Qin
More clinical studies are needed to clarify the risk stratification by the integration of all fusion genes in adult B-cell precursor acute lymphoblastic leukemia (BCP-ALL). A total of 320 consecutive adult Ph-negative BCP-ALL patients who had been tested classical fusions (KMT2A rearrangement and TCF3-PBX1) at diagnosis were further retrospectively screened novel fusion genes (Ph-like, ZNF384 and MEF2D
-
Assessment of clinical utility and predictive potential of pre-chemotherapy soluble urokinase plasminogen activator receptor - observational single center study. Biomol. Biomed. (IF 3.4) Pub Date : 2022-09-08 Elina Beleva, Snezhana Stoencheva, Tanya Deneva, Ivanka Nenova, Zhanet Grudeva-Popova
Alteration of urokinase plasminogen activator receptor (uPAR) in neoplasms is a prerequisite for invasiveness and metastatic ability. In the present study, we aimed to evaluate the relationship of pre-chemotherapy soluble uPAR (suPAR) with the odds for metastasis, lack of disease control, and its predictive ability for progression-free survival (PFS). Baseline plasma suPAR levels were measured by ELISA
-
VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma. Biomol. Biomed. (IF 3.4) Pub Date : 2022-08-27 Lidija Todorović, Boban Stanojević
Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer, with an increasing incidence worldwide. The treatment of PTC is currently the subject of clinical controversy, making it critically important to identify molecular markers that would help improve the risk stratification of PTC patients and optimize the therapeutic approach. The VHL tumor suppressor gene has been implicated
-
Intensity modulated radiation therapy for elderly patients with esophageal cancer: our experience. Biomol. Biomed. (IF 3.4) Pub Date : 2022-08-26 Dan Li, Xiaoxiao Liu, Yuchen Wang, Yingying Jin, Fang Li, Hongbing Ma
The aim of this study was to discuss the treatment mode of radical radiotherapy for elderly patients with esophageal cancer. The clinical data of 136 elderly patients (≥60 years old) with esophageal cancer (EC) who received radical intensity-modulated radiotherapy in the Second Affiliated Hospital of Xi'an Jiaotong University from January 2015 to December 2019 were retrospectively analyzed. Cox risk
-
Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker. Biomol. Biomed. (IF 3.4) Pub Date : 2022-08-26 Lucija Škara, Tonći Vodopić, Ivan Pezelj, Irena Abramovic, Borna Vrhovec, Alen Vrtarić, Nino Sincic, Davor Tomas, Stela Bulimbašić, Tomislav Kuliš, Monika Ulamec
High prevalence and mortality of prostate cancer (PCa) are well known global health issues. Novel biomarkers for better identifying patients with PCa are the subject of extensive research. Prostate specific antigen (PSA) shows low specificity in screening and diagnostics, leading to unnecessary biopsies and health costs. Eighty patients with PCa and benign prostate hyperplasia (BPH) were included in
-
Integrated transcriptomic and proteomic analysis reveals potential targets for heart regeneration. Biomol. Biomed. (IF 3.4) Pub Date : 2022-08-23 Liu Liu, Tongtong Yang, Qiqi Jiang, Liansheng Wang, Jiateng Sun, Lingfeng Gu, Sibo Wang, Yafei Li, Bingrui Chen, Di Zhao, Rui Sun, Qiming Wang, Hao Wang
Research on the regenerative capacity of the neonatal heart could open new avenues for the treatment of myocardial infarction (MI). However, the mechanism of cardiac regeneration remains unclear. In the present study, we constructed a mouse model of heart regeneration and then performed transcriptomic and proteomic analyses on them. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes
-
Prognostic significance of HDL-C on long-term mortality in patients with COVID-19 pneumonia in the Turkish population: A potential mechanism for population differences. Biomol. Biomed. (IF 3.4) Pub Date : 2022-08-22 Ömer Faruk Baycan, Furkan Bölen, Başak Atalay, Mehmet Agirbasli
Coronavirus disease 2019 (COVID-19) is diagnosed by the evidence of the presence of multiple phenotypes, including thrombosis, inflammation, and alveolar and myocardial damage, which can cause severe illness and mortality. High-density lipoprotein cholesterol (HDL-C) has pleiotropic properties, including anti-inflammatory, anti-infectious, antithrombotic, and endothelial cell protective effects. The
-
Impact of subchorionic hematoma on pregnancy outcomes in women with recurrent pregnancy loss. Biomol. Biomed. (IF 3.4) Pub Date : 2022-08-20 Zijie Fu, Xuelei Ding, Dawei Wei, Jun Li, Rong Cang, Xiaodong Li
We conducted a retrospective cohort study with the aim of investigating the relationship between subchorionic hematoma (SCH) and pregnancy outcomes in women with recurrent pregnancy loss (RPL). We reviewed all RPL patients who came to the Fourth Hospital of Shijiazhuang from January 2019 to June 2021. Two groups were divided according to the presence or absence of SCH. Live birth rate was considered
-
PD-L1 testing by immunohistochemistry in Immuno-Oncology. Biomol. Biomed. (IF 3.4) Pub Date : 2022-08-07 Semir Vranic, Zoran Gatalica
Immunotherapy, based on immune checkpoint inhibitors targeting the Programmed cell death ligand 1 (PD-L1) and/or Programmed Death Receptor 1 (PD-1), has substantially improved the outcomes of patients with various cancers. However, only ~30% of patients benefit from immune checkpoint inhibitors. Tumor PD-L1 expression, assessed by immunohistochemistry, is the most widely validated and used predictive
-
Guidelines for breast cancer treatment in Bosnia and Herzegovina. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-25 Lejla Hadžikadić-Gušić, Timur Cerić, Inga Marijanović, Ermina Iljazović, Dijana Koprić, Anela Zorlak, Mahira Tanović, Alma Mekić-Abazović, Ibrahim Šišić, Una Delić, Jasminka Mustedanagić-Mujanović, Alija Aginčić, Edin Bećiragić, Frederick Greene
Breast cancer is the most common cancer among women. In Bosnia and Herzegovina, accurate data on the status of breast cancer are lacking due to the absence of a central registry. Multiple international guidelines imply that institutions that monitor breast cancer patients should have optimal therapeutic options for treatment. In addition, there have been several international consensus guidelines written
-
Evolution of the combined effect of different irrigation solutions and activation techniques on the removal of smear layer and dentin microhardness in oval-shaped root canal - An in-vitro study. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-25 Lu Shi, Jie Wan, Yunfei Yang, Ying Yao, Ruiming Yang, Wen Xie
The aim of this in vitro study was to evaluate the effect of three final irrigants, namely QMix, MTAD and EDTA, combined with three irrigation techniques, namely conventional needle irrigation (CNI), passive ultrasonic irrigation (PUI) and photon-induced photoacoustic streaming (PIPS), on smear layer removal, dentin mineral content and microhardness in oval-shaped canals. 130 decoronated premolars
-
Prediction of pathologic complete response prediction in patients with locally advanced esophageal squamous cell carcinoma treated with neoadjuvant immunochemotherapy: a real-world study. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-24 Jifeng Feng, Liang Wang, Xun Yang, Qixun Chen, Xiangdong Cheng
As an emerging hotspot for patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC), neoadjuvant immunochemotherapy (nICT) is safe and feasible. Pathological complete response (pCR) is considered to be an important therapeutic effect of neoadjuvant therapy. However, few studies have explored pCR predictors for nICT in LA-ESCC. The purpose of this study was to predict pCR after nICT
-
Risk of graft loss in kidney transplant recipients after aortic valve replacement. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-23 Stefan Büttner, Carolin Zöller, Sammy Patyna, Anisa Gradascevic, Helge Weiler, Mark Rosenberg, Thomas Walther, Andreas M Zeiher, Helmut Geiger, Mariuca Vasa-Nicotera, Ingeborg Hauser, Stephan Fichtlscherer
Surgical aortic valve replacement (SAVR) in kidney transplant recipients (KTR) is associated with high morbidity and mortality, and an increased risk of postoperative graft failure potentially leading to graft loss. Transcatheter aortic valve implantation (TAVI) emerged as an alternative in high-risk patients. However, data on TAVI in kidney transplant recipients are limited. We performed a retrospective
-
Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-23 Jiangbo Yan, Gangning Feng, Yong Yang, Dong Ding, Long Ma, Xin Zhao, Xiaolei Chen, Hui Wang, Zhirong Chen, Qunhua Jin
Osteoarthritis (OA) is an age-related degenerative disease characterized by cartilage degeneration and abnormal bone remodeling in the subchondral bone. Autophagy maintains cellular homeostasis by self-phagocytosis. However, the underlying mechanisms of autophagy on the pathological progression of OA are still unknown. This study assessed the effects of autophagy on cartilage and subchondral bone in
-
Clinical and histopathological characteristics of COL4A3 c.2881+1G>A variant causing Alport spectrum disorders in Croatian population. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-19 Matija Horaček, Tamara Nikuševa Martić, Petar Šenjug, Marija Šenjug Perica, Maja Oroz, Sania Kuzmac, Dragan Klarić, Merica Glavina Durdov, Marijan Saraga, Danko Milošević, Danica Batinić, Marijana Ćorić, Frane Paić, Danica Galešić Ljubanović
Alport syndrome (AS) and thin basement membrane nephropathy (TBMN) are part of the spectrum of kidney disorders caused by pathogenic variants in α3, α4, or α5 chains of the collagen type IV, the major structural component of the glomerular basement membrane (GBM). Using targeted next-generation sequencing (NGS), 34 AS/TBMN patients (58.8% male) from 12 unrelated families were found positive for heterozygous
-
Olanzapine decreased osteocyte maturation and Wnt/β-catenin signaling during loading of the alveolar bone in rats. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-19 Saranda Disha-Ibrahimi, Borut Furlani, Gorazd Drevenšek, Samo Hudoklin, Janja Marc, Irena Prodan Žitnik, Jakob Sajovic, Martina Drevenšek
Several studies indicate the influence of olanzapine on bone metabolism; however, the results are contradictory. We evaluated the effects of olanzapine on the Wnt/β-catenin signaling pathway, physiological alveolar bone turnover, and alveolar bone modeling due to an applied orthodontic force. Adult male rats (n=48) were treated with either olanzapine or a vehicle for 21 days; then 8 rats from each
-
Altered fecal microbial and metabolic profile reveals potential mechanisms underlying iron deficiency anemia in pregnant women in China. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-09 Haixia Chen, Weigang Wu, Shuming Tang, Rong Fu, Xia Gong, Hu Hou, Junfa Xu
The gut microbiome and its metabolism may provide crucial insight into the cause of iron deficiency anemia (IDA) in pregnant women. This study aimed to investigate the effect of the gut microbiome and its related metabolites on pregnant women with iron deficiency (ID) and IDA. Maternal cubital venous blood and stool samples were collected from healthy control pregnant women (HC, non-anemic, n=10),
-
Circulating cytokine profile and modulation of regulatory T cells in chronic hepatitis B patients with type 2 diabetes mellitus. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-07 Wang He, Shu Hao, Xiaohui Dong, Dandan Zhang, Zhen Jia
The risk of hepatitis B virus (HBV) infection is higher in patients with diabetes mellitus, and diabetes mellitus is one of the metabolic complications of HBV infection. However, the cytokine profile of chronic hepatitis B (CHB) patients with type 2 diabetes mellitus (T2DM) is not fully understood. The aim of this study was to investigate the cytokine expression profile in CHB patients with T2DM, and
-
Evaluation of qualitative and quantitative taste alterations in COVID-19. Biomol. Biomed. (IF 3.4) Pub Date : 2022-07-07 Angela Pia Cazzolla, Roberto Lovero, Francesca Spirito, Michele Di Cosola, Luigi Santacroce, Eleonora Lo Muzio, Domenico Ciavarella, Mario Dioguardi, Vito Crincoli, Maria Pepe, Lucia Varraso, Renato Contino, Francesca Di Serio, Lorenzo Lo Muzio
Taste dysfunctions occur in a large proportion of COVID-19 patients. This observational study compared interleukin-6 (IL-6) levels in mild and moderate COVID-19 patients with the type (quantitative or qualitative) of taste disorders. The 208 COVID-19 patients (118 men and 90 women) showing only taste dysfunctions as prodromic symptoms were classified as mild and moderate patients. The evaluation of
-
Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-30 Zhaopei Guo, Zian Wang, Ruifeng Liang, Huayu Tian, Xuesi Chen, Meiwan Chen
Camptothecin (CPT) has attracted much attention due to its potent antitumor activities. However, the undesirable physicochemical properties, including poor water-solubility, unstable lactone ring and severe adverse effects limit its further application. In this study, two water-soluble prodrugs, CPT-lysine (CPTK) and CPT-arginine (CPTR), were designed and synthesized by conjugating lysine or arginine
-
Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-30 Özden Yülek, Şebnem Batur, Kerem Özcan, Cansu Yol, Övgü Aydın Ülgen
This study aimed to investigate the programmed cell death-ligand 1 (PD-L1) expression in cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) and its relationship with prognostic factors in tumors that are not in the head and neck region and are therefore relatively less exposed to the sun. This retrospective cross-sectional study included 25 invasive cSCC and 42 BCC cases with a
-
ORM 1 as a biomarker of increased vascular invasion and decreased sorafenib sensitivity in hepatocellular carcinoma. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-29 Jiangning Gu, Shiqi Xu, Xiang Chen, Haifeng Luo, Guang Tan, Wenjing Qi, Feng Ling, Chenqi Wang, Feiliyan Maimaiti, Yunlong Chen, Lili Yang, Menghong Yin, Dan Chen
This study aimed to clarify the role of Orosomucoid 1 (ORM1) in the development and therapy resistance in hepatocellular carcinoma (HCC). The mRNA expression level of ORM1 was analyzed via integrative analysis of Gene Express Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets. The protein expression level of ORM1 in our cohort was determined using immunohistochemistry. Correlation analysis was
-
Evaluation of TyG index and TG/HDL-C ratio in HBeAg negative chronic hepatitis B infected patients. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-27 Tülay Ünver Ulusoy, Heval Can Bilek, Hacer Demirköse, Ayşegül Keleş
Patients with hepatitis B e antigen (HBeAg) negative chronic HBV infection are regularly followed up. This study investigates the presence of insulin resistance and the relationship between hepatosteatosis and insulin resistance in patients with HBeAg negative chronic HBV infection using the TyG index and TG/HDL-C ratio. Patients with HBeAg negative chronic HBV infection who applied to the Infectious
-
Mechanism of OTUD5 in non-small cell lung cancer cell proliferation, invasion, and migration. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-27 Xuebing Li, Baohua Lu, Lina Zhang, Jing Yang, Yurong Cheng, Dong Yan
Ovarian tumor protease deubiquitinase 5 (OTUD5) has been discussed as a regulator of cancer development. Herein, the current study set out to explore the molecular mechanism of OTUD5 in non-small cell lung cancer (NSCLC) cell proliferation, invasion, and migration. Firstly, the expression patterns of OTUD5, phosphatase and tensin homolog (PTEN), as well as microRNA (miR)-652-3p in cells were detected
-
PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-26 Linhai Huang, Chundi Liao, Hanhua Wu, Piwei Huang
Phospholipase C epsilon 1 (PLCE1) is involved in the pathogenesis of many cancers. However, the biological role of PLCE1 in osteosarcoma (OS) is still poorly understood. The prognostic survival analysis was performed on the PLCE1gene in the TARGET data set and the differential expression of PLCE1 in OS tissue and normal bone tissue on the tissue chip was detected by immunohistochemistry. Spearman's
-
Complement C1QC as a potential prognostic marker and therapeutic target in colon carcinoma based on single-cell RNA sequencing and immunohistochemical analysis. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-23 Huiming Deng, Yan Chen, Yong Liu, Li Liu, Ronghua Xu
Immune cell infiltration plays an essential role in the occurrence and development of colon cancer. However, the main tumor-associated immune cell infiltration and its gene regulation in colon cancer still need to be further clarified in order to provide a new perspective for diagnosing and treating this disease. For this study, single-cell RNA sequencing (scRNA-seq) expression profiles and TCGA colon
-
Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/ NF-κB pathway and protecting the intestinal barrier. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-13 Bo Yan, Xiangjie Li, Linxiang Zhou, Yuqing Qiao, Jing Wu, Lanlan Zha, Peilu Liu, Shuai Peng, Baixin Wu, Xiaoyun Yu, Lei Shen
Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase of the Toll-like receptor (TLR)-mediated pathway, considered a new target for treating inflammatory diseases. Studies showed a significant correlation between TLRs and inflammatory responses in ulcerative colitis (UC). Therefore, in this study, after inducing experimental colitis in mice with 3% dextran sulfate sodium (DSS),
-
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-09 Yipeng Xu, Gabriela Pachnikova, He Wang, Yaoyao Wu, Dorothea Przybilla, Reinhold Schäfer, Zihao Chen, Shaoxing Zhu, Ulrich Keilholz
Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining attraction in this area, including prostate cancer (PCa) research. However, nearly all 3D drug design and screening assessments are based on 2D experiments, indicating the limitations of 3D drug testing. To simulate the natural response of human cells
-
Prognostic and predictive significance of VEGF, CD31, and Ang-1 in patients with metastatic clear cell renal cell carcinoma treated with first-line sunitinib. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-08 Marija Kraljević, Inga Marijanović, Maja Barbarić, Emir Sokolović, Merima Bukva, Timur Cerić, Teo Buhovac
The most common type of renal cell carcinoma (RCC) is clear cell renal cell carcinoma (ccRCC), which has a high metastatic potential. Even though the International Metastatic RCC Database Consortium (IMDC) risk model is conventionally utilized for selection and stratification of patients with metastatic RCC (mRCC), there remains an unmet demand for novel prognostic and predictive markers. The goal
-
Predictors of COVID-19 severity among pregnant patients. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-05 Marcin Januszewski, Laura Ziuzia-Januszewska, Alicja A Jakimiuk, Tomasz Oleksik, Marek Pokulniewicz, Waldemar Wierzba, Krzysztof Kozlowski, Artur J Jakimiuk
Coronavirus disease 2019 (COVID-19) was declared a pandemic and has spread around the globe, unsparingly affecting vulnerable populations. Effective prevention measures for pregnant women, who are particularly affected, include early identification of those patients at risk of developing in-hospital complications, and the continuous improvement of maternal-fetal treatment strategies to ensure the efficient
-
Serum microRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma: a meta-analysis. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-04 Yuping Chen, Bingtian Dong, Lichun Huang, Huibin Huang
Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer. Several studies have proposed serum microRNAs (miRNAs) as novel biomarkers for diagnosing PTC. In this study, we conducted a meta-analysis aiming to investigate the overall diagnostic accuracy of serum miRNAs in PTC detection. Three online databases including PubMed, EMBASE and Cochrane Library were searched up to 1 May 2021
-
Serum extracellular vesicle microRNA dysregulation and childhood trauma in adolescents with major depressive disorder. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-03 Liu-Yi Ran, Yi-Ting Kong, Jiao-Jiao Xiang, Qi Zeng, Chen-Yu Zhang, Lei Shi, Hai-Tang Qiu, Chuan Liu, Lin-Li Wu, Ya-Lan Li, Jian-Mei Chen, Ming Ai, Wo Wang, Li Kuang
Major depressive disorder (MDD) seriously endangers adolescent mental and physical health. Extracellular vesicles (EVs) are mediators of cellular communication and are involved in many physiological brain processes. Although EV miRNAshave been implicated in adults with major psychiatric disorders, investigation into their effects in adolescent MDDremains scarce. In discovery set, we conducted a genome-wide
-
Urine amylase level after Whipple resection might be a predictive factor of postoperative complications. Biomol. Biomed. (IF 3.4) Pub Date : 2022-06-03 Farid Ljuca, Amir Tursunović, Kenana Ljuca, Zijah Rifatbegović, Mirha Agić
The association between urine amylase levels and the development of postoperative complications after Whipple resection is still unknown. Aim of this study was to determine the prognostic value of urine amylase levels for postoperative complications in patients who underwent Whipple resection. In this retrospective cohort study, we analyzed amylase levels in urine, serum and drains in 52 patients who
-
Extent of clinical attachment loss as a practical parameter in efficacy of adjunctive photodynamic therapy in stage II - IV grade C Periodontitis (Aggressive periodontitis): A systematic review and meta-analysis. Biomol. Biomed. (IF 3.4) Pub Date : 2022-05-29 Zahra Baghani, Samira Basir Shabestari, Malihe Karrabi
This systematic review and meta-analysis aimed to assess the extent of clinical attachment loss (CAL) as a clinical parameter in the efficacy of antimicrobial photodynamic therapy (aPDT) in non-surgical management of stage II-IV grade C molar-incisor pattern Periodontitis. This review protocol was conducted in accordance with PRISMA statements and is registered in PROSPERO (CRD42022321211). An electronic
-
The first detection of Pneumocystis jirovecii in asthmatic patients post COVID-19 in Jordan. Biomol. Biomed. (IF 3.4) Pub Date : 2022-05-17 Ahmad Riyad Alsayed, Wamidh Talib, Abdullah Al-Dulaimi, Safa Daoud, Mohammed Al Maqbali
Pneumocystis jirovecii pneumonia (PCP), caused by fungal species named Pneumocystis jirovecii, is a frequent opportunistic infection in those with human immunodeficiency virus (HIV) infection. However, PCP has been documented in immunocompetent patients. This study aims to determine if P. jirovecii detection occurs in asthma patients following coronavirus disease 2019 (COVID-19) in a Jordanian cohort
-
Integrating abdominal plain radiographs and clinical data for neonatal necrotizing enterocolitis using hypergraph-based multi-constraint combined non-negative matrix factorization to construct a diagnostic model. Biomol. Biomed. (IF 3.4) Pub Date : 2022-05-15 Guoqiang Qi, Shoujiang Huang, Dengming Lai, Jing Li, Yonggen Zhao, Chen Shen, Jian Huang, Tianmei Liu, Kai Wei, Jinfa Dou, Qiang Shu, Gang Yu
Neonatal necrotizing enterocolitis is a severe neonatal intestinal disease. Timely identification of surgical indications is essential for newborns in order to seek the best time for treatment and improve prognosis. This paper attempts to establish an algorithm model based on multimodal clinical data to determine the features of surgical indications and construct an auxiliary diagnosis model. The proposed
-
The effect of sarcopenia on erlotinib therapy in patients with metastatic lung adenocarcinoma. Biomol. Biomed. (IF 3.4) Pub Date : 2022-05-14 Atakan Topcu, Akin Ozturk, Ismail Yurtsever, Mehmet Besiroglu, Ayse Irem Yasin, Haci Mehmet Turk, Mesut Seker
Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is a status with increasing importance in lung cancer, and it may predict a poor prognosis. We aimed to evaluate the impact of sarcopenia on erlotinib therapy and prognosis in patients with EGFR-mutated (exon 19 or 21
-
The α7nAChR agonist PNU-282987 ameliorates sepsis-induced acute kidney injury via CD4+CD25+ regulatory T cells in rats. Biomol. Biomed. (IF 3.4) Pub Date : 2022-05-10 Xiaocui Shi, Juncong Li, Yuzhen Han, Jingyi Wang, Qingping Li, Yue Zheng, Wenxiong Li
The ameliorative effects of α7 nicotinic acetylcholine receptor (α7nAChR) agonists have been demonstrated in acute kidney injury (AKI) caused by multiple stimulations. However, the ameliorative effect of α7nAChR on sepsis-induced acute kidney injury (SAKI) in the cecal ligation and puncture (CLP) model is unclear. Previous studies have demonstrated that α7nAChR is highly expressed on the surface of
-
Associations of Non-High-density Lipoprotein Cholesterol and Triglyceride/High-density Lipoprotein Cholesterol Ratio with Coronary Plaque Burden and Plaque Characteristics in Young Adults. Biomol. Biomed. (IF 3.4) Pub Date : 2022-05-08 Fatih Akin, İbrahim Altun, Burak Ayca, Nuri Kose, İlknur Altun
Coronary artery disease (CAD) is uncommon in young adult patients. However, these patients have different risk factor profiles and high-risk coronary plaques are more common. The aim of this study was to examine the relations between the coronary plaque burden, plaque composition, serum non-high-density lipoprotein cholesterol (non-HDL-C) levels, and triglyceride/high-density lipoprotein cholesterol
-
ROS responsive polyethylenimine-based fluorinated polymers for enhanced transfection efficiency and lower cytotoxicity. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-30 Peng Hua, Donglin Yang, Ruie Chen, Peiqi Qiu, Meiwan Chen
Cationic polymer polyethylenimine (PEI) plays a crucial role in gene delivery. However, high molecular weight PEI leads to higher efficient transfection efficacy and higher cytotoxicity while low molecular weight PEI exhibits lower transfection performance with lower toxicity. Therefore, effective chemical modification of PEI is required to enhance transfection activity and improve biocompatibility
-
Evaluation of cerebrospinal fluid neurofilament light chain levels in multiple sclerosis and non-demyelinating diseases of the central nervous system: clinical and biochemical perspective. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-30 Burak Arslan, Gökçe Ayhan Arslan, Aslı Tuncer, Rana Karabudak, Aylin Sepici Dinçel
The neurofilament light chain (NfL) is a promising biomarker in the diagnosis, prognosis, and treatment response evaluation of neurological diseases. The aims of this study were to compare the cerebrospinal fluid (CSF) NfL levels in multiple sclerosis (MS) and certain non-demyelinating diseases of the central nervous system (NDCNS); to determine the relationship between clinical and radiological features
-
LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-29 Shuang Qu, Qiao Liao, Cheng Yu, Yue Chen, Han Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A Jose, Zhuxin Li, Wei Eric Wang, Qing Rex Lyu, Chunyu Zeng
The regenerative potential of cardiomyocytes in adult mammals is limited. Previous studies reported that cardiomyocyte proliferation is suppressed by AMP-activated protein kinase (AMPK). The role of liver kinase B1 (LKB1), as the major upstream kinase for AMPK, on cardiomyocyte proliferation is unclear. In this study, we found that the LKB1 levels rapidly increased after birth. With loss- and gain-of-function
-
Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-27 Emana Sheikh, Tony Tran, Semir Vranic, Arkene Levy, R Daniel Bonfil
c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several physiological processes, including pigmentation, hematopoiesis and gut movement. Accumulating evidence suggests that dysregulated c-KIT function, caused by either
-
Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-21 Nikola Serman, Semir Vranic, Mislav Glibo, Ljiljana Serman, Zrinka Bukvic Mokos
Melanoma is a highly aggressive cancer originating from melanocytes. Its etiopathogenesis is strongly related to genetic, epigenetic, and environmental factors. Melanomas encountered in clinical practice are predominantly sporadic, whereas hereditary melanomas account for approximately 10% of the cases. Hereditary melanomas mainly develop due to mutations in the CDKN2A gene, which encodes two tumor
-
First-line treatment of patients with HER2-positive metastatic gastric and gastroesophageal carcinoma. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-17 Selin Aktürk Esen, Yakup Ergun, Cihan Erol, Rukiye Arikan, Muhammed Muhiddin Er, Muhammed Mustafa Atci, Atakan Topçu, Gökhan Uçar, Baran Akagündüz, Musa Bariş Aykan, Miraç Özen, Naziyet Köse Baytemur, Melike Özçelik, Elif Şahin, Denizcan Güven, Serkan Menekşe, Naziye Ak, Fatih Teker, Engin Kut, Teoman Şakalar, Özkan Alan, Turgut Kaçan, Nazim Serdar Turhal, Saadettin Kiliçkap, Sema Türker, Mehmet Ali
Fluoropyrimidine+cisplatin/oxaliplatin+trastuzumab therapy is recommended for the first-line treatment of HER2-positive metastatic gastric adenocarcinoma. However, there is no comprehensive study on which platinum-based treatment should be preferred. This study aimed to compare the treatment response and survival characteristics of patients with HER2-positive metastatic gastric or gastroesophageal
-
Acceptance, effects, and tolerability in the vaccination process against SARS-CoV-2 among cancer patients in Bosnia and Herzegovina: a single-center cross-sectional study. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-08 Timur Ceric, Emir Sokolović, Anes Pašić, Emina Borovac-Gurda, Velda Smajlbegović, Berisa Hasanbegović, Emina Bičakčić Filipović, Elma Kapisazović, Selma Sokolović, Semir Bešlija
The SARS-CoV-2 pandemic has been the main public health issue since the end of 2019. The vaccination campaign in Bosnia and Herzegovina started in April 2021, with several vaccines available. Our study aimed to evaluate the acceptance, effects, and tolerability of vaccines against SARS-COV-2 among cancer patients. We conducted a cross-sectional, observational study between 22 October and 30 November
-
Strategies and safety considerations of booster vaccination in COVID-19. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-03 Hanyan Meng, Jianhua Mao, Qing Ye
First-generation SARS-CoV-2 vaccines have played a significant role in controlling the COVID-19 pandemic, preventing severe diseases, and reducing mortality. However, the continuous emergence of SARS-CoV-2 variants, the persistence of breakthrough infections, and the seemingly rapid decline in the protective efficacy of SARS-CoV-2 vaccines have presented additional challenges for the next phase. There
-
Exploring autophagy related prognostic genes of Alzheimer's disease based on pathway crosstalk analysis. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-02 Fang Qian, Wei Kong, Shuaiqun Wang
Recent studies have shown that different signaling pathways are involved in the pathogenesis of Alzheimer's disease (AD), with complex molecular connections existing between these pathways. Autophagy is crucial for the degradation and production of pathogenic proteins in AD, and it shows link with other AD-related pathways. However, current methods for identifying potential therapeutic targets for
-
Astrocytes and human artificial blood-brain barrier models. Biomol. Biomed. (IF 3.4) Pub Date : 2022-04-01 Tanja Zidarič, Lidija Gradišnik, Tomaž Velnar
The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells, protecting the central nervous system from potentially harmful substances by selectively controlling the entry of cells and molecules, including components of the immune system. To study the BBB properties, find suitable therapies, and identify new drug targets, there is a need to develop representative in vitro
-
Prognostic nomograms for predicting overall survival and cancer-specific survival of patients with very early onset colorectal cancer: a population‑based analysis. Biomol. Biomed. (IF 3.4) Pub Date : 2022-03-27 Bingtian Dong, Yuping Chen, Guorong Lyu
In contrast to the declining incidence in older populations, the incidence of very early onset colorectal cancer (VEO-CRC) patients (aged ≤40 years) has been increasing in different regions of the world. In this study, we aimed to establish nomogram models for the prognostic prediction of patients with VEO-CRC for both overall survival (OS) and cancer-specific survival (CSS). Patients diagnosed with
-
Regulatory aspects of biological medicines in Bosnia and Herzegovina. Biomol. Biomed. (IF 3.4) Pub Date : 2022-03-23 Biljana Tubić, Saša Jungić
The use of the biological medicines, also called "biologics," has contributed to the progress of the treatment of many chronic diseases, such as cancer, rheumatoid arthritis, Crohn's disease, multiple sclerosis, and psoriasis. However, biologicals are expensive for healthcare systems in several countries. Their availability has been a global issue, which has affected many patients that suffer from
-
The Oncology Association of Bosnia and Herzegovina's Recommendations for Fertility Preservation in Oncologic Patients. Biomol. Biomed. (IF 3.4) Pub Date : 2022-03-15 Timur Cerić, Emir Sokolović, Berisa Hasanbegović, Anes Pašić, Zdenka Gojković, Jelena Vladičić Mašić, Nikolina Dukić, Inga Marijanović, Alma Mekić Abazović, Ibrahim Šišić, Dijana Koprić, Mustafa Hammami, Semir Bešlija
Malignancy is one of the major public health problems in Bosnia and Herzegovina. Along with breakthroughs in specific oncological therapy, improving the quality of life of cancer patients and management of therapy-induced side effects need to be recognized as a priority in the comprehensive cancer patient care. Fertility loss after cancer treatment is a field requiring special attention due to its
-
Small cell variant of chromophobe renal cell carcinoma: Clinicopathologic, and molecular-genetic analysis of 10 cases. Biomol. Biomed. (IF 3.4) Pub Date : 2022-03-10 Joanna Rogala, Fumiyoshi Kojima, Reza Alaghehbandan, Nikola Ptakova, Ana Bravc, Stela Bulimbasic, Delia Perez Montiel, Maryna Slisarenko, Leila Ali, Levente Kuthi, Kristyna Pivovarcikova, Kvetoslava Michalova, Boris Bartovic, Adriena Bartos Vesela, Olga Dolejsova, Michal Michal, Ondrej Hes
The morphologic diversity of chromophobe renal cell carcinoma (ChRCC) is well-known. Aside from typical morphology, pigmented adenomatoid, multicystic and papillary patterns have been described. Ten cases of CHRCC composed of small cell population in various percentages were analysed, using morphologic parameters, immunohistochemistry and next-generation sequencing (NGS) testing. Patients were five
-
Identification and Verification of the Ferroptosis- and Pyroptosis-Associated Prognostic Signature for low-grade Glioma. Biomol. Biomed. (IF 3.4) Pub Date : 2022-03-09 Jie Wang, Jie Ren, Jifeng Liu, Linyun Zhang, Qihang Yuan, Bin Dong
Accumulating evidence reveals that ferroptosis and pyroptosis play pivotal roles in tumorigenesis of low-grade glioma (LGG). In this research, we aimed to classify molecular subtypes and further identify and verify a novel multigene signature in LGG on the basis of ferroptosis and pyroptosis-related genes (FPRGs). Raw sequencing data and corresponding clinical data of LGG samples retrieved from the
-
Thiersch graft follow-up with narrow band imaging for Acquired atresia of the external auditory canal: Canaloplasty with thiersch graft vs vascularization evaluated with narrow band imaging. Biomol. Biomed. (IF 3.4) Pub Date : 2022-03-02 Annalisa Pace, Valeria Rossetti, Irene Claudia Visconti, Alessandro Milani, Giannicola Iannella, Antonino Maniaci, Salvatore Cocuzza, Giuseppe Magliulo
Acquired atresia of the external ear canal is a narrowing of the external ear canal (EAC) that appears obstructed by fibrous tissue or bone tissue. Acquired atresia has two different phases: wet and dry stage. Computed tomography (CT) scan may show a scan where soft tissue fills EAC. Treatment may be medical and/or surgical. The surgical treatment of choice is represented by canaloplasty with a skin-free
-
Association between fasting blood glucose and thyroid stimulating hormones and suicidal tendency and disease severity in patients with major depressive disorder. Biomol. Biomed. (IF 3.4) Pub Date : 2022-02-28 Weiting Liu, Zezhen Wu, Min Sun, Shuo Zhang, Juan Yuan, Dan Zhu, Guimimg Yan, Kaijian Hou
Thyroid dysfunction and diabetes are reported to be associated with depression. However, their role in the suicide risk in patients with major depressive disorder (MDD) is unclear. The purpose of this study was to investigate and compare thyroid dysfunction and diabetes between suicide attempters and non-suicide attempters in a large sample of first-episode drug-naïve (FEND) MDD patients. A descriptive