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Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation Redox Rep. (IF 3.8) Pub Date : 2024-03-05 Yanmin Jiang, Lan Xu, Xue Zhu, Xiaowei Zhu, Xiang Xu, Jianbo Li
Diabetic gastrointestinal dysfunction (DGD) is a serious complication of diabetic mellitus (DM), affecting the enteric nervous system (ENS), particular enteric glial cells (EGCs). This study aimed ...
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Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan Redox Rep. (IF 3.8) Pub Date : 2024-02-27 Rania A. Elrashidy, Esraa M. Zakaria, Rehab A. Hasan, Asmaa M. Elmaghraby, Dina A. Hassan, Ranya M. Abdelgalil, Shaimaa R. Abdelmohsen, Amira M. Negm, Azza S. Khalil, Ayat M. S. Eraque, Reem M. Ahmed, Walaa S. Sabbah, Ahmed A. Ahmed, Samah E. Ibrahim
Objectives: Distant liver injury is a complication of renal ischemia-reperfusion (I/R) injury, which imposes mortality and economic burden. This study aimed to elucidate the cross-talk of endoplasm...
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Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice Redox Rep. (IF 3.8) Pub Date : 2024-02-23 Huan Liu, Gang Wei, Tongxing Wang, Yunlong Hou, Bin Hou, Xiaoyan Li, Chao Wang, Mingzhe Sun, Min Su, Zhifang Guo, Lu Wang, Ning Kang, Mengnan Li, Zhenhua Jia
Angelica keiskei is a medicinal and edible plant that has been reported to possess potent antioxidant properties in several in vitro models, but its effectiveness on naturally aging organisms is st...
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Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation Redox Rep. (IF 3.8) Pub Date : 2024-02-08 Yongjun Yang, Qian Chen, Shijun Fan, Yongling Lu, Qianyin Huang, Xin Liu, Xi Peng
Burns and burn sepsis, characterized by persistent and profound hypercatabolism, cause energy metabolism dysfunction that worsens organ injury and systemic disorders. Glutamine (Gln) is a key nutri...
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Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS-mediated signaling pathways Redox Rep. (IF 3.8) Pub Date : 2024-02-06 Jian Liu, Shu-Mei Li, Yan-Jun Tang, Jing-Long Cao, Wen-Shuang Hou, An-Qi Wang, Chang Wang, Cheng-Hao Jin
Jaceosidin (JAC) is a natural flavonoid with anti-oxidant and other pharmacological activities; however, its anti-cancer mechanism remains unclear. We investigated the mechanism of action of JAC in...
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Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis Redox Rep. (IF 3.8) Pub Date : 2023-12-27 Hongyan Zan, Jizheng Liu, Meixia Yang, Honghui Zhao, Chunyan Gao, Yunyan Dai, Zhiming Wang, Hongxuan Liu, Yunfei Zhang
Melittin, the main component of bee venom, is a natural anti-inflammatory substance, in addition to its ability to fight cancer, antiviral, and useful in diabetes treatment. This study seeks to det...
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Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy Redox Rep. (IF 3.8) Pub Date : 2023-12-18 Catalina Rojas-Solé, Víctor Pinilla-González, José Lillo-Moya, Tommy González-Fernández, Luciano Saso, Ramón Rodrigo
Increased life expectancy, attributed to improved access to healthcare and drug development, has led to an increase in multimorbidity, a key contributor to polypharmacy. Polypharmacy is characteris...
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Sulforaphane attenuates irradiation induced testis injury in mice Redox Rep. (IF 3.8) Pub Date : 2023-12-05 Yuanshuai Ran, Nengliang Duan, Zhixiang Gao, Yulong Liu, Xiaolong Liu, Boxin Xue
The testis is vulnerable to ionizing radiation, sexual dysfunction and male infertility are common problems after local radiation or whole-body exposure. Currently, there are no approved drugs for ...
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Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis Redox Rep. (IF 3.8) Pub Date : 2023-12-06 Ahmet Dündar
Infection remains current as an important discussion topic in the etiological factors of atherosclerosis. Ischemic-modified albumin (IMA), galectin-3 (gal-3), paraoxonase-1 (PON-1), and myeloperoxi...
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Evaluation of oxidative stress level: reactive oxygen species, reduced glutathione, and D-dimer in patients hospitalized due to COVID-19 Redox Rep. (IF 3.8) Pub Date : 2023-12-02 Claudionei Roessler, Karen Cristine Silva de Oliveira, Auricélia Xavier de Oliveira Portella, Paulo Cezar Nunes Fortes, Franciéle Romero Machado, Stífani Machado Araujo, Marina Prigol, Léia Carolina Lucio, Dalila Moter Benvegnú, Lirane Elize Defante Ferreto
Elevated D-dimer levels at hospital admission may also indicate a higher likelihood of progressing to a severe or critical state. This study aimed to assess reactive oxygen species (ROS), non-enzym...
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Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies Redox Rep. (IF 3.8) Pub Date : 2023-12-02 Jie Gao, Liming Tao, Zhengxuan Jiang
This review outlines the function of oxidative stress in DR and discusses therapeutic strategies to treat DR with antioxidants.Published papers on oxidative stress in DR and therapeutic strategies ...
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Melittin kills A549 cells by targeting mitochondria and blocking mitophagy flux Redox Rep. (IF 3.8) Pub Date : 2023-12-02 Xuan Li, Zheng Li, Yu-Qi Meng, Hui Qiao, Ke-Rong Zhai, Zhen-Qing Li, Shi-Lin Wei, Bin Li
Melittin, a naturally occurring polypeptide found in bee venom, has been recognized for its potential anti-tumor effects, particularly in the context of lung cancer. Our previous study focused on i...
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Obstructive sleep apnea promotes the progression of lung cancer by modulating cancer cell invasion and cancer-associated fibroblast activation via TGFβ signaling Redox Rep. (IF 3.8) Pub Date : 2023-11-27 Zhilei Cui, Zhengshang Ruan, Meigui Li, Rongrong Ren, Yizong Ma, Junxiang Zeng, Jinyuan Sun, Wenjing Ye, Weiguo Xu, Xuejun Guo, Dengfei Xu, Linlin Zhang
Obstructive sleep apnea (OSA) is associated with severity of pneumonia; however, the mechanism by which OSA promotes lung cancer progression is unclear.Twenty-five lung cancer patients were recruit...
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Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis Redox Rep. (IF 3.8) Pub Date : 2023-11-27 Virendra Kumar Yadav, Nisha Choudhary, Amel Gacem, Rakesh Kumar Verma, Mohd Abul Hasan, Mohammad Tarique Imam, Ziyad Saeed Almalki, Krishna Kumar Yadav, Hyun-Kyung Park, Tathagata Ghosh, Pankaj Kumar, Ashish Patel, Haresh Kalasariya, Byong-Hun Jeon, Hassan Ali AlMubarak
Ferroptosis is an emerging and novel type of iron-dependent programmed cell death which is mainly caused by the excessive deposition of free intracellular iron in the brain cells. This deposited fr...
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L-methionine protects against nephrotoxicity induced by methotrexate through modulation of redox status and inflammation Redox Rep. (IF 3.8) Pub Date : 2023-11-06 Wessam M. Abdel-Wahab, Nada S. Daifalla, Amina E. Essawy
Objective: Methotrexate (MTX) is a drug used in the treatment of cancer and autoimmune disorders; however, its clinical use is limited because of serious side effects including renal toxicity. This...
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Oxidative stress signaling in the pathogenesis of diabetic cardiomyopathy and the potential therapeutic role of antioxidant naringenin Redox Rep. (IF 3.8) Pub Date : 2023-09-25 Nan Xu, Siqi Liu, Yongqiang Zhang, Yujing Chen, Yumei Zuo, Xiaoqiu Tan, Bin Liao, Pengyun Li, Jian Feng
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders that poses a global threat to human health. It can lead to complications in multiple organs and tissues, owing to its wide-ra...
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Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes Redox Rep. (IF 3.8) Pub Date : 2023-09-26 Yifan Liu, Kaimin Wu, Yinkun Fu, Wenyan Li, Xu-Yun Zhao
Primary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolatio...
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Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice Redox Rep. (IF 3.8) Pub Date : 2023-09-20 Jun Qian, Yun Li, Yanyun Wang, Qunying Ye, Hongbo Luo
Mitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main...
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Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis Redox Rep. (IF 3.8) Pub Date : 2023-08-31 Zhi-Qiang Ouyang, Li-shi Shao, Wei-peng Wang, Teng-fei Ke, Dong Chen, Guang-rong Zheng, Xi-rui Duan, Ji-xiang Chu, Yu Zhu, Lu Yang, Hai-yan Shan, Lin Huang, Cheng-de Liao
ABSTRACT Objective It is very important to develop a new therapeutic strategy to cope with the increasing morbidity and mortality of chronic kidney disease (CKD). As a kind of physical therapy, low intensity pulsed ultrasound (LIPUS) has remarkable anti-inflammatory and repair-promoting effects and is expected to become a new therapeutic method for CKD. This study aims to clarify the treatment effect
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Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect Redox Rep. (IF 3.8) Pub Date : 2023-08-29 Kai-Hua Xue, Yi-Fan Jiang, Ji-Yu Bai, Di-Ze Zhang, Yu-Hang Chen, Jian-Bin Ma, Zhi-Jing Zhu, Xinyang Wang, Peng Guo
ABSTRACT Background Metabolic alteration drives renal cell carcinoma (RCC) development, while the impact of melatonin (MLT), a neurohormone secreted during darkness, on RCC cell growth and underlying mechanisms remains unclear. Methods We detected concentration of metabolites through metabolomic analyses using UPLC-MS/MS, and the oxygen consumption rate was determined using the Seahorse Extracellular
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Analysis of an antioxidative defence system of hydrogen peroxide-treated pancreatic islet-derived 1.1B4 cells and siRNA targeting NR4A3-treated cells by microarray Redox Rep. (IF 3.8) Pub Date : 2023-08-15 Motoko Nakayama, Etsuko Ueta, Mitsuru Yoshida, Yuri Shimizu, Atsuko Tokuda, Yasuko Sone, Yuri Nomi, Y. Otsuka
ABSTRACT Pancreatic islet β-cells weaken under oxidative stress. In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a human microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) and jun B proto-oncogene were upregulated, whereas superoxide dismutase
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Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway Redox Rep. (IF 3.8) Pub Date : 2023-08-11 Ju Huang, Yu Zhu, Songtao Li, Huanyu Jiang, Nianzhi Chen, Hang Xiao, Jingwen Liu, Dan Liang, Qiao Zheng, Jianyuan Tang, Xiangrui Meng
ABSTRACT Background Acute lung injury (ALI) is a severe and often fatal pulmonary disease. Current treatments for ALI and acute respiratory distress syndrome (ARDS) are limited. Natural product metabolites have shown promise as therapeutic alternatives. However, the effects of Licochalcone B (LCB) on ALI are largely unknown. Methods We investigated the effects of LCB on lipopolysaccharide-challenged
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Reduction of butyric acid-producing bacteria in the ileal mucosa-associated microbiota is associated with the history of abdominal surgery in patients with Crohn’s disease Redox Rep. (IF 3.8) Pub Date : 2023-08-02 Osamu Handa, Hiroto Miura, Tingting Gu, Motoyasu Osawa, Hiroshi Matsumoto, Eiji Umegaki, Ryo Inoue, Yuji Naito, Akiko Shiotani
ABSTRACT Fecal microbiota is a significant factor determining the cause, course, and prognosis of Crohn’s disease (CD). However, the factors affecting mucosa-associated microbiota (MAM) remain unclear. This retrospective study examined the differences in ileal MAM between CD patients and healthy controls and investigated the factors affecting MAM in CD patients to clarify potential therapeutic targets
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Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1α/RORγt pathway Redox Rep. (IF 3.8) Pub Date : 2023-07-13 Zenghui Liu, Lixuan Chen, Defang Xiong, Yu Zhan, Jiduo Liu, Ling Ouyang, Wancheng Chen, Ziyuan Lu, Tianqi Gao, Xiaozhen Li, Yanqun Zhou, Xuekui Gu, Yang Xiao
ABSTRACT Background Acquired aplastic anemia (AA) is a life-threatening disease associated with an imbalance in Th17/Treg cells. Regulating this balance may be an effective treatment approach for AA. Rhodiola rosea has shown efficacy in AA treatment, but its mechanisms remain unclear. Purpose We investigated salidroside's effect (a component of Rhodiola rosea) on Th17/Treg balance in adult AA patients
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Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats Redox Rep. (IF 3.8) Pub Date : 2023-06-22 Elizabeth Enohnyket Besong, Tunmise Maryanne Akhigbe, Precious Jesutofunmi Ashonibare, Abimbola Ayoola Oladipo, Jacinta Nkechi Obimma, Moses Agbomhere Hamed, Damilare Hakeem Adeyemi, Roland Eghoghosoa Akhigbe
ABSTRACT Aim: The present study evaluated the effect of lead exposure with and without zinc therapy on male sexual and erectile function. Methods: Twenty male Wistar rats were randomly assigned into four groups; the control, zinc-treated, lead-exposed, lead + zinc-treated groups. Administrations were per os daily for 28 days. Results: Zinc co-administration significantly improved absolute and relative
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Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure Redox Rep. (IF 3.8) Pub Date : 2023-06-20 Shan Mi, Feng Huang, Mingli Jiao, Zhuang Qian, Mingming Han, Zheng Miao, Heqin Zhan
ABSTRACT The long non-coding RNA, maternally expressed gene 3 (MEG3), are involved in myocardial fibrosis and compensatory hypertrophy, but its role on cardiomyocyte apoptosis and autophagy in heart failure (HF) remains unclear. The aim of this study was to investigate the effect of MEG3 on cardiomyocyte apoptosis and autophagy and the underlying mechanism. A mouse model of HF was established by subcutaneous
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Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation Redox Rep. (IF 3.8) Pub Date : 2023-06-06 Wu Ying, Song Meiyan, Chen Wen, Xu Kaizu, Wu Meifang, Lin Liming
ABSTRACT Objective To investigate the effects of glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on endothelial dysfunction in LDL receptor-deficient (LDLR-KO) mice and ox-LDL-challenged human umbilical vein endothelial cells (HUVECs) and its possible mechanism. Methods LDLR-KO mice were randomly treated with normal saline, liraglutide, or liraglutide plus a GLP-1R antagonist exendin-9
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Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway Redox Rep. (IF 3.8) Pub Date : 2023-06-01 Hanan M. Hassan, Nouf M. Alatawi, Alaa Bagalagel, Reem Diri, Ahmad Noor, Deina Almasri, Hussain T. Bakhsh, Hussam I. Kutbi, Noha Ashy, Mohammed M. H. Al-Gayyar
ABSTRACT Objectives Gastric ulcer (GU) is a prevalent chronic digestive disease affecting about 10% of the world's population leading to gastrointestinal perforation and bleeding. Genistein is a legume flavonoid with antioxidants, anti-inflammatory and antibacterial activities. Therefore, we aimed to investigate the ability of genistein to reduce experimentally induced GU in rats by affecting gastric
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Relevance of oxidative stress biomarkers, hemoglobin A1c, troponin-I, and angiotensin-converting enzyme metabolism to blood pressure in acute myocardial infarction: a case-control study Redox Rep. (IF 3.8) Pub Date : 2023-05-16 Sounira Mehri, Raja Chaaba, Josef Finsterer, Wided Khamlaoui, Sonia Hammami, Mohamed Hammami
ABSTRACT The aim was to investigate this relationship by calculating 1) the correlation between peak troponin-C (peak-cTnI), levels of oxidative stress biomarkers, including lipid peroxidation products (malondialdehyde (MDA), conjugated dienes (CD)), and antioxidant enzyme activity (glutathione peroxidase (GPx)), and HbA1c and 2) the correlation between HbA1c and serum angiotensin-converting enzyme
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The consumption of Sechium edule (chayote) has antioxidant effect and prevents telomere attrition in older adults with metabolic syndrome Redox Rep. (IF 3.8) Pub Date : 2023-05-04 Graciela Gavia-García, Juana Rosado-Pérez, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez, Edelmiro Santiago-Osorio, Víctor Manuel Mendoza-Núñez
ABSTRACT Objective To determine the effect of the consumption of Sechium edule (1.5 g/day) for six months on oxidative stress (OxS) and inflammation markers and its association with telomere length (TL) in older adults with metabolic syndrome (MetS). Methods The study was conducted in a sample of 48 older adults: placebo (EP) and experimental (EG) groups. Lipoperoxides, protein carbonylation, 8-OHdG
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Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt Redox Rep. (IF 3.8) Pub Date : 2023-04-27 Ziling Wang, Kunhang Du, Jiying Hou, Hanxianzhi Xiao, Ling Hu, Xiongbin Chen, Lu Wang, Yaping Wang
ABSTRACT Objectives: High reactive oxygen species (ROS) levels lead to cell death, and the testes are among the most vulnerable organs to oxidative damage. Rg1, an active ingredient extracted from the natural medicine ginseng, has potential anti-inflammatory, antioxidant and antiapoptotic properties. Our previous studies showed that Rg1 can effectively improve spermatogenic function in mice, but the
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Hydroxytyrosol attenuates ethanol-induced liver injury by ameliorating steatosis, oxidative stress and hepatic inflammation by interfering STAT3/iNOS pathway Redox Rep. (IF 3.8) Pub Date : 2023-03-18 Xianying Fang, Jiamin Cao, Zhi Tao, Zhiqing Yang, Yuan Dai, Linguo Zhao
ABSTRACT Objective: Hydroxytyrosol (HT) is a polyphenol with a wide range of biological activities. Excessive drinking can lead to oxidative stress and inflammation in the liver, which usually develop into alcohol liver disease (ALD). At present, there is no specific drug to treat ALD. In this paper, the protection effect of HT on ALD and the underline mechanism were studied. Methods: HepG2 cells were
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Cystathionine γ-lyase S-sulfhydrates SIRT1 to attenuate myocardial death in isoprenaline-induced heart failure Redox Rep. (IF 3.8) Pub Date : 2023-02-09 Dan Wu, Yuanyuan Sun, Yijing Gu, Deqiu Zhu
ABSTRACT Objective: Hydrogen sulfide (H2S), the third gasotransmitter, plays a critical role in protecting against heart failure. Sirtuin-1 (SIRT1) is a highly conserved histone deacetylase that has a protective role in the treatment of heart failure by regulating the deacetylation of some functional proteins. This study investigates the interaction between SIRT1 and H2S in heart failure and the underlying
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Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats Redox Rep. (IF 3.8) Pub Date : 2023-02-04 Bin Hu, Tian Tian, Xin-Tao Li, Pei-Pei Hao, Wei-Chao Liu, Ying-Gui Chen, Tian-Yu Jiang, Pei-Shan Chen, Yi Cheng, Fu-Shan Xue
ABSTRACT Objectives To observe the protective effects of dexmedetomidine (Dex) postconditioning on myocardial ischemia/reperfusion injury (IRI) and to explore its potential molecular mechanisms. Methods One-hundred forty-seven male Sprague-Dawley rats were randomly divided into five groups receiving the different treatments: Sham, ischemia/reperfusion (I/R), Dex, Brusatol, Dex + Brusatol. By the in
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Ndufaf2, a protein in mitochondrial complex I, interacts in vivo with methionine sulfoxide reductases Redox Rep. (IF 3.8) Pub Date : 2023-02-04 Sujin Park, José A. Trujillo-Hernandez, Rodney L. Levine
ABSTRACT Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure. However, very few in vivo binding partners or substrates of the reductases have been identified. Methods We implemented a proximity labeling method, TurboID, to covalently link mitochondrial
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LncRNA Fendrr: involvement in the protective role of nucleolin against H2O2-induced injury in cardiomyocytes Redox Rep. (IF 3.8) Pub Date : 2023-01-31 Cheng Chen, Xiaofang Lin, Yuting Tang, Hui Sun, Leijing Yin, Zhengyang Luo, Shuxin Wang, Pengfei Liang, Bimei Jiang
ABSTRACT Background: Nucleolin is a multifunctional nucleolar protein with RNA-binding properties. Increased nucleolin expression protects cells from H2O2-induced damage, but the mechanism remains unknown. Long noncoding RNAs (lncRNAs) play crucial roles in cardiovascular diseases. However, the biological functions and underlying mechanisms of lncRNAs in myocardial injury remain unclear. Methods: In
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Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis Redox Rep. (IF 3.8) Pub Date : 2023-01-24 Xing-Qiang Dong, Li-Kai Chu, Xu Cao, Qian-Wei Xiong, Yi-Ming Mao, Ching-Hsien Chen, Yun-Li Bi, Jun Liu, Xiang-Ming Yan
ABSTRACT Renal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acute renal dysfunction and eventual chronic kidney diseases (CKD). The chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its executing mechanisms of action are versatile and elusive. Here, we show that cisplatin induces renal
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Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue Redox Rep. (IF 3.8) Pub Date : 2023-01-20 Hanem M. Rabah, Darin A. Mohamed, Reham A. Mariah, Sarah R. Abd El-Khalik, Haidy A. Khattab, Norhan A. AbuoHashish, Amal M. Abdelsattar, Mohamed A. Raslan, Eman E. Farghal, Amira K. Eltokhy
ABSTRACT Purpose Polycystic ovary syndrome (PCOS) has a series of reproductive and metabolic consequences. Although the link between PCOS, IR, and obesity, their impact on the pathogenesis of PCOS has yet to be determined. Dysfunction of PI3K/AKT pathway has been reported as the main cause of IR in PCOS. This study purposed to explore the effects of selenium nanoparticles (SeNPs) alone and combined
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Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation Redox Rep. (IF 3.8) Pub Date : 2023-01-20 Masahiro Adachi, Kota Yanagizono, Yasuhito Okano, Hitoshi Koizumi, Isao Uemaetomari, Keiji Tabuchi
ABSTRACT Cisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity. In this study, we investigated the effect of E2 on nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated hair cell protection using the organ of Corti
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Reduced hydrogen sulfide production contributes to adrenal insufficiency induced by hypoxia via modulation of NLRP3 inflammasome activation Redox Rep. (IF 3.8) Pub Date : 2023-01-20 Ningning Zhang, Zhan Zhou, Yan Huang, Gang Wang, Zhengshan Tang, Jianqiang Lu, Changnan Wang, Xin Ni
ABSTRACT Objective: Adrenocortical responsiveness is critical for maintaining glucocorticoids production and homeostasis during stress. We sought to investigate adrenocortical responsiveness during hypoxia in mice and the mechanisms responsible for the regulation of adrenal responsiveness. Methods: (1) Adult male WT mice were randomly divided into four groups: normoxia, hypoxia (24h), hypoxia (72h)
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Evaluation of targeted oxidative stress induced by oxygen-ozone in vitro after ischemic induction Redox Rep. (IF 3.8) Pub Date : 2022-11-10 Jessica Rodrigues Orlandin, Sarah Ingrid Pinto Santos, Luciana Cristina Machado, Paulo Fantinato Neto, Fabiana Fernandes Bressan, Naira Caroline Godoy Pieri, Kaiana Recchia, Meline de Paula Coutinho, Priscilla Avelino Ferreira Pinto, Annalisa Santucci, Valter Travagli, Carlos Eduardo Ambrosio
ABSTRACT Encephalic vascular accident, or stroke, is the most common pathology of the central nervous system in humans, the second leading cause of death and physical and cognitive disabilities, in developing countries. It presents as an ischemic (more common) or hemorrhagic form. Ozone therapy has been shown to be effective in neuromodulation, neuroprotection, and nerve regeneration. The present study
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Caffeine reduces oxidative stress to protect against hyperoxia-induced lung injury via the adenosine A2A receptor/cAMP/PKA/Src/ERK1/2/p38MAPK pathway Redox Rep. (IF 3.8) Pub Date : 2022-11-10 Xijuan Wang, Shuai Lv, Jianwei Sun, Meihui Zhang, Lei Zhang, Yan Sun, Ziyan Zhao, Dandan Wang, Xinjing Zhao, Jiajie Zhang
ABSTRACT Objectives: Caffeine has been shown to reduce the incidence of bronchopulmonary dysplasia (BPD). To investigate the protective mechanism of caffeine in a hyperoxia-based cell model of BPD in vitro. Methods: Type II alveolar epithelial cells (AECs II) were isolated and randomly divided into 6 groups: the normal, hyperoxia, caffeine (50 μM caffeine), antagonist (5 μM ZM241385), agonist (5 μM
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Zinc oxide nanoparticles and spironolactone-enhanced Nrf2/HO-1 pathway and inhibited Wnt/β-catenin pathway in adenine-induced nephrotoxicity in rats Redox Rep. (IF 3.8) Pub Date : 2022-11-07 Amira Awadalla, Eman T. Hamam, Fardous F. El-Senduny, Nisreen Mansour Omar, Mohamed R. Mahdi, Nashwa Barakat, Omar A. Ammar, Abdelaziz M. Hussein, Ahmed A. Shokeir, Salma M. Khirallah
ABSTRACT Objective To investigate the renoprotective, the antioxidant, and the anti-inflammatory impact of a combination of SPL and ZnO-NPs to combat against chronic kidney disease (CKD). Methods In total, 50 males of rats were distributed into 5 groups (10 rats each); normal group, adenine sulfate (0.25% in diet for 10 days) (CKD) group. After the last dose of adenine sulfate, rats were divided into
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Swinhoeic acid from Potentilla fragarioides ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2 Redox Rep. (IF 3.8) Pub Date : 2022-10-19 Huankai Yao, Min Kong, Dan Du, Fengwei Ai, Jindong Li, Yan Li
ABSTRACT Objectives Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Oxidative stress resulting from high glucose promotes accumulation of ECM and development of DN. Activation of Nrf2 could attenuate oxidative stress and following accumulation of ECM. To find novel therapy for DN, we explored the effects of swinhoeic acid from Potentilla fragarioides
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β-catenin ISGylation promotes lipid deposition and apoptosis in ethanol-stimulated liver injury models Redox Rep. (IF 3.8) Pub Date : 2022-10-19 Qi Ding, Guodong Zhang, Yang Wang, Lei Xu, Meifei Wu, Yiwen Zhou, Tao Xu, Xiaoming Meng, Cheng Huang, Lei Zhang
ABSTRACT Background The restoration of the Wnt/β-catenin pathway to alleviate alcoholic fatty liver disease (AFLD) progression is under study as a new strategy for alcoholic liver disease (ALD) treatment. Recent studies have indicated that interferon-stimulated gene 15 (ISG15) can covalently bind to β-catenin by HECT E3 ubiquitin ligase 5 (HERC5), leading to ISG degradation and downregulation of β-catenin
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Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury Redox Rep. (IF 3.8) Pub Date : 2022-10-06 O. A. Afolabi, M. A. Hamed, D. C. Anyogu, D. H. Adeyemi, A. F. Odetayo, R. E. Akhigbe
ABSTRACT Background Oxidative damage is critical in the pathogenesis of ovarian ischaemia/reperfusion (I/R) injury, and statins have been reported to exert antioxidant activity. However, the role of VCAM-1 and xanthine oxidase (XO)/uric acid (UA) in ovarian I/R injury is not known. Also, whether or not atorvastatin exerts antioxidant activity like other statins is unclear. Objectives This study investigated
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Chili-supplemented food decreases glutathione-S-transferase activity in Drosophila melanogaster females without a change in other parameters of antioxidant system Redox Rep. (IF 3.8) Pub Date : 2022-10-06 Uliana V. Semaniuk, Dmytro V. Gospodaryov, Olha M. Strilbytska, Alicja Z. Kucharska, Anna Sokół-Łętowska, Nadia I. Burdyliuk, Kenneth B. Storey, Maria M. Bayliak, Oleh Lushchak
ABSTRACT Objectives Many plant-derived anti-aging preparations influence antioxidant defense system. Consumption of food supplemented with chili pepper powder was found to extend lifespan in the fruit fly, Drosophila melanogaster. The present study aimed to test a connection between life-extending effect of chili powder and antioxidant defense system of D. melanogaster. Methods Flies were reared for
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The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1 Redox Rep. (IF 3.8) Pub Date : 2022-09-30 Yangmeng Zhao, Yuxin Xie, Xiaolong Li, Jing Song, Menglu Guo, Dehai Xian, Jianqiao Zhong
ABSTRACT Background Inflammation and oxidative stress (OS) are important contributors to psoriasis pathogenesis. Proanthocyanidins (PCs) have anti-inflammatory and anti-oxidative activities. Previously, we discovered that PCs alleviated psoriasis-like mice symptoms, likely via mitigating inflammation and OS damage. Objective To elucidate the protective mechanism underlying PCs against the damage of
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Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss Redox Rep. (IF 3.8) Pub Date : 2022-09-26 Jingying Wang, Yinghao Pan, Guangmin Wei, Hanxiao Mao, Rulan Liu, Yuanmin He
ABSTRACT Objectives The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis. Methods Published papers on vitiligo, oxidative stress and DAMPs were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc. Results Oxidative stress may be an important inducer
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Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners Redox Rep. (IF 3.8) Pub Date : 2022-09-20 Sebastian Bańkowski, Miroslav Petr, Michał Rozpara, Ewa Sadowska-Krępa
ABSTRACT Background The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO2max and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle. Methods Thirty runners were randomly assigned to a placebo group (PL) and a curcumin-supplemented group (CU). Their VO2max was assessed
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Fisetin ameliorates oxidative glutamate testicular toxicity in rats via central and peripheral mechanisms involving SIRT1 activation Redox Rep. (IF 3.8) Pub Date : 2022-09-01 Fatma H. Rizk, Nema A. Soliman, Suzan E. Abo-Elnasr, Heba A. Mahmoud, Muhammad T. Abdel Ghafar, Rasha A. Elkholy, Ola A. ELshora, Reham A. Mariah, Shaimaa Samir Amin Mashal, Amira A. El Saadany
ABSTRACT Objectives This study aimed to evaluate the potential mitigating effect of fisetin on monosodium glutamate (MSG)-induced testicular toxicity and investigate the possible involvement of silent mating type information regulation 2 homolog 1 (SIRT1) in this effect. Methods Forty male rats were divided into normal control, fisetin-treated, MSG-treated, and fisetin + MSG-treated groups. Testosterone
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Correction Redox Rep. (IF 3.8) Pub Date : 2022-08-16
Published in Redox Report: Communications in Free Radical Research (Vol. 27, No. 1, 2022)
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miR-34a induces neutrophil apoptosis by regulating Cdc42-WASP-Arp2/3 pathway-mediated F-actin remodeling and ROS production Redox Rep. (IF 3.8) Pub Date : 2022-08-06 Meiwan Cao, Baoling Peng, Huan Chen, Min Yang, Peiyu Chen, Liping Ye, Hongli Wang, Lu Ren, Jing Xie, Jingnan Zhu, Xiangye Xu, Wanfu Xu, Lanlan Geng, Sitang Gong
ABSTRACT Background The number of neutrophils is significantly reduced in myelodysplastic syndrome (MDS), but the molecular basis remains unclear. We recently found that miR-34a was significantly increased in MDS neutrophils. Therefore, this study aims to clarify the effects of aberrant miR-34a expression on neutrophil counts. Methods miR-34a mimics/inhibitor transfection were performed in neutrophil-like
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Beneficial role of naringin against methotrexate-induced injury to rat testes: biochemical and ultrastructural analyses Redox Rep. (IF 3.8) Pub Date : 2022-07-21 Hany Elsawy, Abdullah M. Alzahrani, Manal Alfwuaires, Ashraf M. Abdel-Moneim, Mahmoud Khalil
ABSTRACT Background Methotrexate (MTX) is a commonly used chemotherapeutic drug that has adverse toxic effects on germ cells. Naringin (NG) is a natural flavanone glycoside, with different phytotherapeutic applications, and its possible protective effects against MTX-induced testicular tissue damage were investigated in this study. Methods Low and high doses of NG (40 and 80 mg/kg/day) were given for
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Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study Redox Rep. (IF 3.8) Pub Date : 2022-07-13 Candida Zuchegna, Antonio Porcellini, Samantha Messina
ABSTRACT Background Although the protooncogenes small GTPases Ras are redox-sensitive proteins, how they are regulated by redox signaling in the central nervous system (CNS) is still poorly understood. Alteration in redox-sensitive targets by redox signaling may have myriad effects on Ras stability, activity and localization. Redox-mediated changes in astrocytic RAS may contribute to the control of
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Sevoflurane reduces lipopolysaccharide-induced apoptosis and pulmonary fibrosis in the RAW264.7 cells and mice models to ameliorate acute lung injury by eliminating oxidative damages Redox Rep. (IF 3.8) Pub Date : 2022-07-08 Fushuang Zheng, Xiuying Wu, Jin Zhang, Zhiling Fu, Yan Zhang
ABSTRACT Objectives Sevoflurane is identified as an effective candidate drug for acute lung injury (ALI) treatment, but its curing effects and detailed mechanisms have not been fully disclosed. The present study was designed to resolve this academic issue. Methods The ALI mice models were established, and Hematoxylin-eosin staining assay was performed to examine tissue morphologies. Cell viability
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Therapeutic effects of sulforaphane in ulcerative colitis: effect on antioxidant activity, mitochondrial biogenesis and DNA polymerization Redox Rep. (IF 3.8) Pub Date : 2022-06-26 Abdullah Alattar, Reem Alshaman, Mohammed M. H. Al-Gayyar
ABSTRACT Objectives Ulcerative colitis (UC), an inflammatory bowel disease, affects mucosal lining of colon leading to inflammation and ulcers. Sulforaphane is a natural compound obtained from cruciferous vegetables. We aimed to investigate potential therapeutic effects of sulforaphane in experimentally induced UC in rats through affection antioxidant activity, mitochondrial biogenesis and DNA polymerization
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Norcantharidin down-regulates iron contents in the liver and spleen of lipopolysaccharide-treated mice Redox Rep. (IF 3.8) Pub Date : 2022-06-23 Jie Zheng, Jiao-Jiao Wang, Hui-Min Ma, Meng-Qi Shen, Zhong-Ming Qian, Yu-Xin Bao
ABSTRACT Objective The inhibiting effect of Norcantharidin (NCTD) on IL-6 (interleukin-6) and STAT3 and the involvement of the IL-6/STAT3 pathway in hepcidin expression prompted us to speculate that NCTD could affect iron metabolism. Methods We examined the effects of NCTD on serum iron (SI) and transferrin (Tf) saturation, iron and ferritin light chain (FTL), transferrin receptor 1 (TfR1), divalent
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Suppression of glutathione system and upregulation of caspase 3-dependent apoptosis mediate rohypnol-induced gastric injury Redox Rep. (IF 3.8) Pub Date : 2022-05-10 R. E. Akhigbe, D. T. Oluwole, T. E. Adegoke, M. A. Hamed, D. C. Anyogu, A. F. Ajayi
ABSTRACT Objectives: This study investigated the impact of rohypnol on gastric tissue integrity. Methods: Forty male Wistar rats were randomized into control, low dose rohypnol-treated, high dose rohypnol-treated, low dose rohypnol-treated recovery and high dose rohypnol-treated recovery groups. Results: Rohypnol caused significant rise in gastric malondialdehyde (MDA), oxidized glutathione (GSSG)
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Hydrogen sulfide protects retina from blue light-induced photodamage and degeneration via inhibiting ROS-mediated ER stress-CHOP apoptosis signal Redox Rep. (IF 3.8) Pub Date : 2022-04-28 Sen Zhu, Xuan Li, Bingrong Dang, Fen Wu, Kexin Gou, Chunming Wang, Changjun Lin
ABSTRACT Background: Hydrogen sulfide (H2S) is a small reducing gas molecule with various biological functions such as anti-oxidative, anti-apoptotic and anti-inflammatory activities. In this study, we investigated the therapeutic effects of exogenous H2S in the experimental models of retinal photodamage in vivo and in vitro. Methods: Rats with open eyelids were pretreated with H2S (80~120 μmol/kg)