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Histopathologic clues to the etiopathogenesis of orbital inflammatory disease: idiopathic, IgG4-related, neoplastic, autoimmune and beyond Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-30 Anna M. Stagner
Orbital inflammatory diseases represent a heterogenous group of idiopathic, autoimmune-related, and sometimes neoplastic conditions with overlapping clinical and histopathologic features, as well as variable levels of IgG4-positive plasma cells detected within tissue biopsies. Some histopathologic features, especially in an appropriate clinical context, may point to a specific diagnosis in a given
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TABLE OF CONTENTS (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-18
Abstract not available
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COVER (PMS 180&K) (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-18
Abstract not available
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MASTHEAD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-18
Abstract not available
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EDITORIAL BOARD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-18
Abstract not available
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The History of the Microscope Reflects Advances in Science and Medicine Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-11 Caitlin A. Noble, Andrew P. Biesemier, Sarah McClees, Aljunaid Alhussain, Stephen E. Helms, Robert T. Brodell
Microscopes, more than any other instrument, reflect advances in clinical medicine over the past several hundred years. As the primary tool of the pathologist, they were, and continue to be, a key connector between the bedside and basic sciences. One specific example is the science of clinical dermatology, which relies on clinical-pathologic correlation to make a definitive diagnosis. The microscopes
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Pathology of Hereditary Renal Cell Carcinoma Syndromes Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-07 Chin-Lee Wu
Abstract not available
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Mark Wick contributions to pathology of the mediastinum Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-07 Horacio Maluf
Mark Wick made a wide range of contributions to the field of mediastinal pathology. Early papers amplified the spectrum of neuroendocrine carcinomas of the thymus and brought attention to the aggressive nature of this tumor, also highlighting the occurrence of coexisting carcinoid tumor and small cell carcinoma of this organ. The controversial issue of thymoma classification was addressed in several
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Birt-Hogg-Dubé syndrome in an overall view: Focus on the clinicopathological prospects in renal tumors Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-06 Jialong Wu, Jian Lu, Chin-Lee Wu, Min Lu
Birt-Hogg-Dubé syndrome (BHD) represents a rare autosomal dominant tumor predisposition syndrome characterized by skin lesions, lung cysts, and renal tumors. The predominant histological subtypes of BHD-related renal tumors include hybrid oncocytoma-chromophobe tumors, oncocytomas, and chromophobe renal cell carcinomas, all exhibiting eosinophilic/oncocytic features. Immunohistochemistry staining for
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Mimickers of Immunoglobulin G4-related Hepatobiliary Disease on Biopsy Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-06 Byoung Uk Park, Hee Eun Lee, Lizhi Zhang
With the growing recognition of IgG4-related hepatobiliary disease, establishing a definitive diagnosis relies mainly on a combination of clinical findings, serological markers, and imaging modalities. However, the role of histopathological evaluation remains indispensable, particularly in cases necessitating differential diagnosis or malignancy exclusion. While diagnosing IgG4-related hepatobiliary
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IgG4-related lymphadenopathy Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-05 Wah Cheuk, Jabob R. Bledsoe
IgG4-related lymphadenopathy is a nodal manifestation of IgG4-related disease (IgG4RD) which is characterized by increased polytypic IgG4+ plasma cells and IgG4+/IgG+ plasma cell ratio in lymph nodes and morphologically manifested as various patterns of reactive lymphadenopathy: Castleman disease-like, follicular hyperplasia, interfollicular expansion, progressive transformation of germinal centers
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Clinical-pathologic Correlation: The Impact of Grossing at the Bedside Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-05 C. Alexis Noble, Chinmoy Bhate, Buu Duong, Allison Cruse, Robert T. Brodell, Riley Hanus
The unenlightened clinician may submit a skin specimen to the lab and expect an “answer.” The experienced clinician knows that in performing skin biopsies, it is critical to select the most appropriate: 1) anatomic location for the biopsy1,2; 2) type of biopsy1,2; 3) depth and breadth of the biopsy; and 4) medium for hematoxylin and eosin staining (formalin) or direct immunofluorescence (Michel's Transport
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Contributions of Dr. Wick to the pathology of diseases of the lung and pleura. Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-05 Saul Suster
The curriculum vitae of Dr. Mark R. Wick contains 57 peer-reviewed publications, 3 editorials, 6 book chapters and a whole book dedicated to diseases of the lung and pleura. It is remarkable that such productivity should represent only a small portion of the overall output of Dr. Wick, which includes (at last count) 341 original peer-review publications, 119 invited review articles, 93 book chapters
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Unraveling the Complexities of IgG4-Related Disease: Musings from a Histopathologist Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-04 Vikram Deshpande
Abstract not available
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Autoimmune pancreatitis: Biopsy interpretation and differential diagnosis Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-03 Yoh Zen
Autoimmune pancreatitis (AIP) is classified into type 1 (IgG4-related) and type 2 (IgG4-unrelated) and the interpretation of pancreatic biopsy findings plays a crucial role in their diagnosis. Needle biopsy of type 1 AIP in the acute or subacute phase shows a diffuse lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis, and the infiltration of many IgG4-positive plasma cells. In
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Advancements in Diagnosing IgG4-Related Disease of the Head and Neck: Navigating Diagnostic Pitfalls Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2024-01-01 Munita Bal, Vikram Deshpande
IgG4-related disease (IgG4-RD) is an immune-mediated condition affecting nearly any organ. This review focuses on the nuances of diagnosing IgG4-RD affecting the head and neck. Salivary gland involvement, especially of the submandibular glands, often permits a definitive diagnosis on biopsy. However, elevated IgG4+ plasma cells are nonspecific and can be seen in chronic sialadenitis, lymphoma, and
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IgG4-Related Kidney Disease: Clinicopathologic Features, Differential Diagnosis, and Mimics Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-12-20 Sarwat I. Gilani, Alessia Buglioni, Lynn D. Cornell
IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial nephritis (IgG4-TIN), and then IgG4-related membranous glomerulonephritis (IgG4-MGN), we now recognize additional patterns of interstitial nephritis, glomerular disease, and vascular disease that can be seen as part of IgG4-RKD
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Hereditary papillary renal cell carcinoma Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-12-15 Isa Mulingbayan Jacoba, Zhichun Lu
Hereditary papillary renal cell carcinoma (HPRCC) is an autosomal dominant syndrome characterized by the occurrence of bilateral and multifocal, classic type papillary renal cell carcinomas. In the recent decades, extensive molecular studies have narrowed the molecular underpinnings of this syndrome to missense mutations in tyrosine kinase domain of MET proto-oncogene. Although MET mutations are specific
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CHALLENGES AND PITFALLS IN THE DIAGNOSIS OF IgG4-RELATED DISEASE Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-11-15 ADRIAN C. BATEMAN, EMMA L. CULVER
IgG4-related disease (IgG4-RD) is a relatively novel fibroinflammatory condition characterised typically by dense lymphoplasmacytic inflammation, storiform fibrosis and obliterative venulitis, together with prominent IgG4+ plasma cells and an IgG4+/IgG+ plasma cell ratio of >40%. The diagnosis is usually made on a combination of clinical and serological features together with characteristic radiological
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Kidney cancer: Links between hereditary syndromes and sporadic tumorigenesis Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-11-17 Michel Alchoueiry, Kristine Cornejo, Elizabeth P. Henske
Multiple hereditary syndromes predispose to kidney cancer, including Von Hippel-Lindau syndrome, BAP1-Tumor Predisposition Syndrome, Hereditary Papillary Renal Cell Carcinoma, Tuberous Sclerosis Complex, Birt-Hogg-Dubé syndrome, Hereditary Paraganglioma–Pheochromocytoma Syndrome, Fumarate Hydratase Tumor Predisposition Syndrome, and Cowden syndrome. In some cases, mutations in the genes that cause
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Differential Diagnosis of IgG4-Positive Plasma Cells in the Lung Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-11-15 Sanjay Mukhopadhyay
The recognition of immunoglobulin G4-related disease (IgG4-RD) as an entity in the pancreaticobiliary tract was followed by a slew of papers describing inflammation and fibrosis containing IgG4-positive plasma cells in a variety of sites including the respiratory tract, leading to the hypothesis that these abnormalities were attributable to IgG4-RD. Predictably, pathologists began to see requests from
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Diagnostic Work-up of Hematological Malignancies with Underlying Germline Predisposition Disorders (GPD) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-11-10 Rashmi Kanagal-Shamanna, Kristian T. Schafernak, Katherine R. Calvo
Hematological malignancies with underlying germline predisposition disorders have been recognized by the World Health Organization 5th edition and International Consensus Classification (ICC) classification systems. The list of genes and the associated phenotypes are expanding and involve both pediatric and adult populations. While the clinical presentation and underlying molecular pathogenesis are
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Hereditary succinate dehydrogenase-deficient renal cell carcinoma Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-11-08 Joanna Rogala, Ming Zhou
Succinate dehydrogenase (SDH), formed by four subunits SDHA, SDHB, SDHC, SDHD, and an assembly factor SDHAF2, functions as a key respiratory enzyme. Biallelic inactivation of genes encoding any of the components, almost always in the presence of a germline mutation, causes loss of function of the entire enzyme complex (so-called SDH deficiency) and subsequent development of SDH-deficient neoplasms
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von Hippel–Lindau disease-related neoplasia with an emphasis on renal manifestations Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-11-08 Burak Tekin, Lori A. Erickson, Sounak Gupta
von Hippel–Lindau (VHL) disease is characterized by biallelic inactivation of the VHL gene leading to abnormal or absent VHL protein function, and constitutive activation of hypoxia-inducible factors (HIF) that leads to pro-tumorigenic signaling. Individuals with VHL disease develop numerous cysts and tumors involving multiple organs including the kidneys, central nervous system, endolymphatic sac
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Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-11-04 Alexandra E. Kovach, Brent L. Wood
Lymphoblastic leukemia/lymphoma (ALL/LBL), especially certain subtypes, continues to confer morbidity and mortality despite significant therapeutic advances. The pathologic classification of ALL/LBL, especially that of B-ALL, has recently substantially expanded with the identification of several distinct and prognostically important genetic drivers. These discoveries are reflected in both current classification
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Pathology of hereditary renal cell carcinoma syndromes: Tuberous sclerosis complex (TSC) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-09-20 Miranda E. Machacek, Chin-Lee Wu, Kristine M. Cornejo
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease characterized by hamartomatous tumors involving multiple organs such as the brain, skin, heart, lung and kidney. TSC is caused by inactivating mutations in TSC1/TSC2, which encodes hamartin and tuberin, respectively, and forms a complex that regulates mechanistic target of rapamycin complex 1 (mTORC1), resulting in cell overgrowth
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COVER (PMS 180&K) (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-08-19
Abstract not available
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MASTHEAD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-08-19
Abstract not available
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EDITORIAL BOARD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-08-19
Abstract not available
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TABLE OF CONTENTS (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-08-19
Abstract not available
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Post-transplant lymphoproliferative disorders (PTLD) in adolescents and young adults: A category in need of definition Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-08-01 Amy Chadburn
Post-transplant lymphoproliferative disorders are a well-recognized complication of solid organ and stem cell transplantation. Much data has accumulated with respect to the pathobiology and clinical behavior of these lesions in the general post-transplant population as well as in the pediatric and adult age groups. However, information as to these lesions in the adolescent and young adult populations
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COVER (PMS 180&K) (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-07-12
Abstract not available
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MASTHEAD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-07-12
Abstract not available
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EDITORIAL BOARD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-07-12
Abstract not available
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TABLE OF CONTENTS (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-07-12
Abstract not available
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A personalized approach to lymphoproliferations in patients with inborn errors of immunity Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-07-11
Biopsies from patients with inborn error of immunity (IEI) may pose a diagnostic challenge due to the abnormal anatomy of their lymphoid organs and the tendency for the development of lymphoproliferations in various organs, some of which may lead to the wrong impression of malignant lymphoma which may prompt aggressive unnecessary treatment. In this article we will review typical histologic findings
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Classic Hodgkin lymphoma in young people Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-06-30 Srishti Gupta, Jeffrey W. Craig
Classic Hodgkin lymphoma (CHL) is a unique form of lymphoid cancer featuring a heterogeneous tumor microenvironment and a relative paucity of malignant Hodgkin and Reed-Sternberg (HRS) cells with characteristic phenotype. Younger individuals (children, adolescents and young adults) are affected as often as the elderly, producing a peculiar bimodal age-incidence profile that has generated immense interest
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Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: a practical approach for the pathologist Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-06-28 Jingwei Li, Jacob R. Bledsoe
The diagnostic work up and surveillance of germline disorders of bone marrow failure and predisposition to myeloid malignancy is complex and involves correlation between clinical findings, laboratory and genetic studies, and bone marrow histopathology. The rarity of these disorders and the overlap of clinical and pathologic features between primary and secondary causes of bone marrow failure, acquired
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Small biopsies in the head and neck: Bone and soft tissue Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-06-29 Aarti E Sharma, Darcy A Kerr, Nicole A Cipriani
Bone and soft tissue lesions in the head and neck encompass not only a broad morphologic spectrum but also significant inherent clinicopathologic overlap. Epidemiology, radiology, and location – similar to the diagnostic assessment in other sites – are especially important considerations in the context of an established mesenchymal proliferation. Herein, the approach towards diagnosis is stratified
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Approach to small biopsies in the larynx Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-06-25 Abberly Lott Limbach
Small biopsies in the larynx can make a definitive diagnosis challenging due to the sampling or tangential sectioning. The differential diagnosis can be divided into mucosal lesions (squamous papillomas, intraepithelial dysplasia, and invasive squamous cell carcinoma) or submucosal lesions (vocal cord polyps/nodules, amyloidosis, granular cell tumor, rhabdomyoma, neuroendocrine neoplasms, salivary
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The many faces of Atypical fibroxanthoma Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-06-23 Abbas Agaimy
Atypical fibroxanthoma (AFX) is an uncommon, primary dermal neoplasm of uncertain histogenesis, typically originating in the sun-damage skin of the head and neck of the elderly. Since first description in 1958, ∼3000 cases have been reported in the literature. However, the disease is underreported as the neoplasm is considered a standard diagnosis in the last decades. On the other hand, many earlier
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Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-06-22 Amrit Singh, Ifeyinwa E. Obiorah
Mature non-Hodgkin lymphomas (NHLs) of the pediatric and young adults(PYA), including Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL), high-grade B cell lymphoma (HGBCL), primary mediastinal large B cell lymphoma (PMBL) and anaplastic large cell lymphoma (ALCL), generally have excellent prognosis compared to the adult population. BL, DLBCL and HGBCL are usually of germinal center (GCB)
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Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-06-01 Rachel A. Mariani, Elizabeth L. Courville
Benign lymphadenopathy is common in the pediatric population and may be clinically striking. As in adults, lymph node evaluation in pediatric patients requires careful morphologic and immunohistochemical assessment and clinical contextualization of the findings. It is important for the pathologist to be familiar with benign and reactive conditions that may mimic malignancy. This review presents non-neoplastic
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The Changing Landscape of Pediatric Histiocytoses: Birth, Life, and Transdifferentiation of Pediatric Histiocytes Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-05-20 Aaron Auerbach, Nadine S. Aguilera
Histiocytic neoplasms in the children are very rare, and histiocytoses can occur in the perinatal period. The presumed origins and presentation of specific histiocytoses in the pediatric age group are described. Common and newly described histiocytoses are presented including Langerhans cell histiocytosis, Rosai-Dorfman disease, histiocytic sarcoma, ALK positive histiocytosis, and hemophagocytic lymphohistiocytosis
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COVER (PMS 180&K) (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-05-16
Abstract not available
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MASTHEAD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-05-16
Abstract not available
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EDITORIAL BOARD (p/u from previous issue) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-05-16
Abstract not available
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TABLE OF CONTENTS (p/u from previous issue w/updates) Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-05-16
Abstract not available
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Preface: An update on superficial mesenchymal tumors: How the explosion of data translates into every day clinical practice Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-05-12 Konstantinos Linos
Abstract not available
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Indeterminate Thyroid Nodules and Advances in Molecular Pathology Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-05-03 Brendan Belovarac, Fang Zhou, Jake Sharma, Tamar C. Brandler
Thyroid cytology has in recent years been augmented by molecular testing for indeterminate lesions. Three commercial molecular tests are available which provide variable amounts of detail regarding the genetic alterations identified in a sample. This paper will describe these tests, as well as the common molecular drivers associated with papillary thyroid carcinoma (PTC) and follicular patterned lesions
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Superficial mesenchymal tumours expressing epithelial markers on immunohistochemistry: Diagnostic clues and pitfalls Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-28 Vanghelita Andrei, Simon Haefliger, Daniel Baumhoer
The diagnosis of mesenchymal neoplasms arising in the superficial soft tissue can be challenging as some entities are rare and show overlapping features. Moreover, the spectrum of mesenchymal tumours has expanded recently to include potential new entities, some of which have been described after the 5th edition of the World Health Organisation (WHO) classification of soft tissue and bone tumours published
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Benign and low-grade superficial endothelial cell neoplasms in the molecular era Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-28 Julio A Diaz-Perez, Darcy A Kerr
Vascular tumors are the most common mesenchymal neoplasms of the skin and subcutis, and they encompass a heterogeneous group with diverse clinical, histological, and molecular features, as well as biological behavior. Over the past two decades, molecular studies have enabled the identification of pathogenic recurrent genetic alterations that can be used as additional data points to support the correct
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Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-25 Grant M. Fischer, David J. Papke Jr
Cutaneous mesenchymal neoplasms are diagnostically challenging because of their overlapping morphology, and, often, the limited tissue in skin biopsy specimens. Molecular and cytogenetic techniques have identified characteristic gene fusions in many of these tumor types, findings that have expanded our understanding of disease pathogenesis and motivated development of useful ancillary diagnostic tools
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An update on selected cutaneous (myo) fibroblastic mesenchymal tumors Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-25 Natalia Georgantzoglou, Konstantinos Linos
Cutaneous (myo)fibroblastic tumors constitute a group of tumors with overlapping clinicopathological features and variable biologic behavior. In the present review we focus on the histomorphology, immunohistochemical profile and molecular background of the following entities: dermatofibrosarcoma protuberans (DFSP), CD34-positive fibroblastic tumor (SCD34FT), myxoinflammatory sarcoma (MIFS), low-grade
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Application of immunohistochemical studies in diagnosing emerging superficial mesenchymal neoplasms Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-25 Kasey J. McCollum, Rami N. Al-Rohil
Molecular diagnostics, with the subsequent development of novel immunohistochemical markers, continues to advance and expand the field of soft tissue pathology. As such, the ever-evolving molecular diagnostic landscape will continue to shape and refine our understanding and classification of neoplasms. This article reviews the current literature on various tumors of mesenchymal origin, including f
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The new and old in superficial mesenchymal tumors with uncertain origin and/or melanocytic differentiation Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-25 Ahmad Alkashash, Azadeh Samiei, Ahmed K. Alomari
Abstract not available
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Contemporary diagnostic approach to atypical vascular lesion and angiosarcoma Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-25 Cooper D. Rutland, Gregory R. Bean, Gregory W. Charville
Vascular neoplasms account for a substantial fraction of cutaneous mesenchymal tumors, spanning from clinically indolent benign lesions to highly aggressive malignancies. These neoplasms present a distinctive challenge in terms of their diagnostic histopathology, both because of the breadth of their morphological manifestations and because of the significant histological overlap between different entities
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Myelodysplastic syndrome: Approach to diagnosis in the era of personalized medicine Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-18 Paul Barone, Sanjay Patel
Abstract not available
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Myeloid sarcoma: An overview Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-17 Maximiliano Ramia de Cap, Weina Chen
Myeloid Sarcoma (MS) is a high grade, hematological malignancy defined as an extramedullary tumor mass of myeloid blasts with or without maturation that effaces tissue architecture. It is a highly heterogenous condition that represents a variety of myeloid neoplasms. This heterogeneity of MS, together with its rarity, have greatly hampered our understanding of the condition. Diagnosis requires tumor
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Salivary gland neoplasms in small biopsies and fine needle aspirations Semin. Diagn. Pathol. (IF 2.3) Pub Date : 2023-04-17 Jalal B. Jalaly, Zubair W. Baloch
Salivary gland neoplasms are rare and represent a diverse group of head and neck tumors. Their diagnosis in limited cellularity specimens can be challenging as many of these have overlapping clinical, radiological presentation, and pathologic features. Fine needle aspiration and/or core biopsies are more of a norm than rarity to be performed preoperatively to provide invaluable information that can