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Sexually transmitted coinfections among at-risk HIV-positive MSM: implications for optimal preemptive treatment Front. Med. (IF 3.9) Pub Date : 2024-03-15 Tzong-Yow Wu, Kuan-Yin Lin, Li-Hsin Su, Hsin-Yun Sun, Yu-Shan Huang, Wang-Da Liu, Wen-Chun Liu, Lan-Hsin Chang, Sui-Yuan Chang, Chien-Ching Hung
BackgroundConcurrent sexually transmitted infections (STIs) are common in sexually active populations. We aimed to estimate the prevalence and coinfection rates of bacterial STIs among sexually active, HIV-positive men who have sex with men (MSM), and to assess the potential benefits of different combination treatment regimens in managing concurrent bacterial STIs.MethodsFrom September 2021 to September
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Single cell analysis of short-term dry eye induced changes in cornea immune cell populations Front. Med. (IF 3.9) Pub Date : 2024-03-15 Jehan Alam, Ebru Yaman, Gerda Cristal Villalba Silva, Rui Chen, Cinita S. de Paiva, Mary Ann Stepp, Stephen C. Pflugfelder
BackgroundDry eye causes corneal inflammation, epitheliopathy and sensorineural changes. This study evaluates the hypothesis that dry eye alters the percentages and transcriptional profiles of immune cell populations in the cornea.MethodsDesiccating stress (DS) induced dry eye was created by pharmacologic suppression of tear secretion and exposure to drafty low humidity environment. Expression profiling
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Nano-radiopharmaceuticals as therapeutic agents Front. Med. (IF 3.9) Pub Date : 2024-03-15 Tanu Dixit, Nayomi Dave, Kausani Basu, Pranav Sonawane, Trutuja Gawas, Selvan Ravindran
In recent years, there has been an increased interest in exploring the potential synergy between nanotechnology and nuclear medicine. The application of radioactive isotopes, commonly referred to as radiopharmaceuticals, is recognized in nuclear medicine for diagnosing and treating various diseases. Unlike conventional pharmaceutical agents, radiopharmaceuticals are designed to work without any pharmacological
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Basal cell carcinoma—a clinical indicator of immunosuppression Front. Med. (IF 3.9) Pub Date : 2024-03-14 Lucian G. Scurtu, Marian Petrica, Francesca Scurtu, Anca Angela Simionescu, Marco I. Popescu, Olga Simionescu
BackgroundBasal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are skin-derived carcinomas. The literature strongly connects SCC with acquired immunosuppression. Current data regarding BCC’s association with immunosuppressive comorbidities are vague. The primary objective of this study was to establish the correlations between BCC and immunosuppressive comorbidities of patients. Materials and
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Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease Front. Med. (IF 3.9) Pub Date : 2024-03-14 Xiaohan Jin, Yu Yang, Guangmei Chen, Yue Shao, Chang Liu, Rong Li, Yazhuo Liu, Lichuan Zhang
BackgroundBody composition changes are important extrapulmonary manifestations in chronic obstructive pulmonary disease (COPD) patients. This study aimed to investigate the characteristics of body composition in patients with COPD, and its correlation with disease severity.MethodsA total of 105 COPD patients admitted to Zhongshan Hospital affiliated to Dalian University, from May 1, 2021 to January
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Analysis of the main indicators and risk factors of ultrasonic shear wave elastography for the diagnosis of osteoarthritis among adults Front. Med. (IF 3.9) Pub Date : 2024-03-14 Jiong Zhang, Xiaozuo Zheng, Ying Zhao
ObjectiveThis study was conducted to explore the main indicators of ultrasonic shear wave elastography (SWE) for the diagnosis of osteoarthritis (OA) and its influencing factors.MethodsWe collected 910 patients between January 2018 and November 2023 from the department of ultrasound, Third Hospital of Hebei Medical University. Logistic regression was used to analyze the effects of age, gender, body
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Development and validation of a prognostic nomogram for 3-year all-cause mortality risk among elderly patients undergoing surgery for osteoporotic fractures Front. Med. (IF 3.9) Pub Date : 2024-03-14 Chong Li, Qin Shi, Ya-qin Gong, Ting Zhang, Ke Lu
IntroductionTo develop and validate a comprehensive prognostic model for the mid-to-long term mortality risk among ≥50-year-old osteoporotic fracture (OPF) surgical patients.MethodsOur retrospective investigation included data from the Osteoporotic Fracture Registration System established by the Affiliated Kunshan Hospital of Jiangsu University, and involved 1,656 patients in the development set and
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Collapsing glomerulopathy is likely a major contributing factor for worse allograft survival in patients receiving kidney transplants from black donors Front. Med. (IF 3.9) Pub Date : 2024-03-14 Lanny T. DiFranza, Emily Daniel, Geo Serban, Steven M. Thomas, Dominick Santoriello, Lloyd E. Ratner, Vivette D. D’Agati, Elena-Rodica Vasilescu, Syed Ali Husain, Ibrahim Batal
Although a few registry-based studies have shown associations between receiving kidney allografts from Black donors and shorter allograft survival, detailed, large, single-center studies accounting for common confounding factors are lacking. Furthermore, pathologic alterations underlying this potential disparity have not been systematically studied. We performed a retrospective clinical-pathological
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Population health in primary care Front. Med. (IF 3.9) Pub Date : 2024-03-14 David A. Haggstrom, Robert A. Gabbay, William L. Miller, Jenna Howard, Benjamin F. Crabtree
Population health in the United States continues to lag behind other wealthy nations. Primary care has the promise of enhancing population health; however, the implementation of a population health approach within primary care deserves further consideration. Clinicians and staff from a national sample of 10 innovative primary care practices participated in a working conference to reflect upon population
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Development and validation of a machine learning model to predict prognosis in liver failure patients treated with non-bioartificial liver support system Front. Med. (IF 3.9) Pub Date : 2024-03-13 Shi Shi, Yanfen Yang, Yuanli Liu, Rong Chen, XiaoXia Jia, Yutong Wang, Chunqing Deng
Background and objectivesThe prognosis of liver failure treated with non-bioartificial liver support systems is poor. Detecting its risk factors and developing relevant prognostic models still represent the top priority to lower its death risk.MethodsAll 215 patients with liver failure treated with non-bioartificial liver support system were retrospectively analyzed. Potential prognostic factors were
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An evaluation of rehabilitation students’ learning goals in their first year: a text mining approach Front. Med. (IF 3.9) Pub Date : 2024-03-13 Shin Kitamura, Kotaro Takeda, Shintaro Uehara, Taiki Yoshida, Hirofumi Ota, Shigeo Tanabe, Kazuya Takeda, Soichiro Koyama, Hiroaki Sakurai, Yoshikiyo Kanada
IntroductionQualitative information in the form of written reflection reports is vital for evaluating students’ progress in education. As a pilot study, we used text mining, which analyzes qualitative information with quantitative features, to investigate how rehabilitation students’ goals change during their first year at university.MethodsWe recruited 109 first-year students (66 physical therapy
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Clinical observation of a modified technique for intrascleral fixation of flanged three-piece foldable intraocular lenses through a Hoffman pocket Front. Med. (IF 3.9) Pub Date : 2024-03-13 Hongfei Ye, Mengxiao Wu, Wan Sun, Jiao Lyu, Yu Xu, Ping Fei, Jie Peng, Haiying Jin, Peiquan Zhao
PurposeTo present the outcomes of a new technique for intrascleral fixation of a flanged three-piece foldable intraocular lens (IOL) without a conjunctival incision.Materials and methodsWe retrospectively reviewed a consecutive series of 12 eyes of 12 patients who underwent scleral IOL fixation using this technique.ResultsThe follow-up period ranged 3–12 months. There was a significant improvement
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The effectiveness and safety of lifestyle medicine and integrative therapies in inflammatory arthritis: an umbrella review using a hierarchical evidence gathering approach Front. Med. (IF 3.9) Pub Date : 2024-03-13 Joshua Lin, Jing Liu, Allana O’Fee, Chhiti Pandey, Sarah Benna-Doyle, Alison Maunder, Vibhuti Rao, Simon Alesi, Beverly Ng, Carolyn Ee
ObjectiveAn umbrella review was conducted to provide a comprehensive evaluation of the evidence on lifestyle medicine and integrative therapies for inflammatory arthritis.MethodsFive electronic databases were searched for umbrella reviews, meta-analyses, and systematic reviews of randomised controlled trials on acupuncture, diet, exercise, herbal medicine, nutrient supplements, and mind–body therapies
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Use and acceptance of traditional, complementary and integrative medicine in Germany—an online representative cross-sectional study Front. Med. (IF 3.9) Pub Date : 2024-03-13 Michael Jeitler, Miriam Ortiz, Benno Brinkhaus, Mike Sigl, Rasmus Hoffmann, Miriam Trübner, Andreas Michalsen, Manfred Wischnewsky, Christian S. Kessler
BackgroundOlder representative surveys show that Traditional, Complementary and Integrative Medicine (TCIM) is used by about 60% of the German population. However, no data exists for the current nationwide situation. The main aim of this cross-sectional study is to investigate the current use and acceptance of TCIM in Germany.MethodsThis study is based on a representative sample of the German population
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Efficacy and safety of platelet-rich plasma for acute nonarteritic anterior ischemic optic neuropathy: a prospective cohort study Front. Med. (IF 3.9) Pub Date : 2024-03-13 Xin Jin, Junxia Fu, Ruju Lv, Xiaolu Hao, Song Wang, Mingming Sun, Guangcan Xu, Qi Zhang, Lei Zhang, Yan Li, Quangang Xu, Baoke Hou
BackgroundAs the most common acute optic neuropathy in older patients, nonarteritic anterior ischemic optic neuropathy (NAION) presents with varying degrees of visual acuity loss and visual field defect. However, there is no generally accepted treatment for NAION.ObjectivesTo evaluate the efficacy and safety of platelet-rich plasma (PRP) for patients with acute NAION within 2 months.DesignA prospective
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C-reactive protein-to-albumin ratio and neutrophil-to-albumin ratio for predicting response and prognosis to infliximab in ulcerative colitis Front. Med. (IF 3.9) Pub Date : 2024-03-12 Yanyan Zhang, Feng Xu, Ya Li, Bing Chen
The C-reactive protein-to-albumin ratio (CAR) and neutrophil-to-albumin ratio (NAR) serve as established markers for inflammatory diseases. However, limited studies have investigated their potential in predicting response and prognosis following infliximab (IFX) treatment. The objective of this paper was to evaluate feasibility of CAR and NAR as biomarkers to assess response to IFX induction therapy
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Causality between allergic diseases and kidney diseases: a two-sample Mendelian randomization study Front. Med. (IF 3.9) Pub Date : 2024-03-12 Zhe Peng, Xinyu Dong, Yingxin Long, Zunjiang Li, Yueyao Wang, Wei Zhu, Banghan Ding
BackgroundEvidence from observational studies and clinical trials suggests that the allergic diseases (ADs) are associated with kidney diseases (KDs). However, the causal association between them remains to be determined. We used bidirectional two-sample Mendelian randomization (MR) analysis to evaluate the potential causality between them.MethodsMendelian randomization (MR) was performed using publicly
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Agreement between PSMA-RADS and E-PSMA systems in classifying [18F]PSMA-1007 PET/CT lesions among prostate cancer patients: exploring the correlation between lesion size and uptake Front. Med. (IF 3.9) Pub Date : 2024-03-12 Miguel Mendoza-Ávila, Hiram Esparza-Pérez, Juan Andrés Castillo-López, Edel Rafael Rodea-Montero
PurposeTo determine the agreement between the PSMA-RADS and E-PSMA standardized reporting systems in the classification of [18F]PSMA-1007–uptaking lesions identified on PET/CT scan in patients with prostate cancer (PCa) and post-prostatectomy with suspected recurrent disease (local recurrence, regional nodal involvement and distant metastases), based on biochemical recurrence, while also exploring
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Case Report: Dostarlimab for treatment of aggressive cutaneous squamous cell carcinoma Front. Med. (IF 3.9) Pub Date : 2024-03-11 Sophia Gandarillas, Horace Tang, Bahar Dasgeb
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy with the aggressive cSCC subtype being especially worrisome due to its higher metastatic and mortality rate. An 80-year-old immunocompetent Caucasian man presented with a locally advanced and recurrent cSCC for which he underwent six Mohs surgeries, radiation therapy, and standard immunotherapy treatments. Throughout treatment
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Association between HDL-C and chronic pain: data from the NHANES database 2003–2004 Front. Med. (IF 3.9) Pub Date : 2024-03-11 Panpan Mi, Haoran Dong, Shengle Chen, Xuan Gao, Xu Cao, Yong Liu, Huijie Wang, Guofeng Fan
ObjectiveHigh-density lipoprotein cholesterol (HDL-C) has been reported to be associated with pain symptoms of various diseases, and its anti-inflammatory and antioxidant mediation is related to the pathogenesis of chronic pain. This study aims to evaluate the relationship between HDL-C levels and chronic pain in American adults.MethodsThis cross-sectional study used data from American adults aged
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Recent advances in the therapeutic management of calcium pyrophosphate deposition disease Front. Med. (IF 3.9) Pub Date : 2024-03-11 Paraskevi V. Voulgari, Aliki I. Venetsanopoulou, Alexandros A. Drosos
Calcium pyrophosphate deposition (CPPD) disease is a form of crystal-induced arthropathy that arises from the accumulation of calcium pyrophosphate crystals within joints and soft tissues. This process leads to inflammation and damage to the affected joints. It can present asymptomatically or as acute or chronic inflammatory arthritis. Risk factors and comorbidities, including prior joint injury, osteoarthritis
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Evaluation of peri-plaque pericoronary adipose tissue attenuation in coronary atherosclerosis using a dual-layer spectral detector CT Front. Med. (IF 3.9) Pub Date : 2024-03-11 Yulin Jia, Lei Zou, Ming Xue, Xiaoyu Zhang, Xigang Xiao
PurposeThis study aimed to evaluate the differences between pericoronary adipose tissue (PCAT) attenuation at different measured locations in evaluating coronary atherosclerosis using spectral computed tomography (CT) and to explore valuable imaging indicators.MethodsA total of 330 patients with suspicious coronary atherosclerosis were enrolled and underwent coronary CT angiography with dual-layer
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Addressing bias in the definition of SARS-CoV-2 reinfection: implications for underestimation Front. Med. (IF 3.9) Pub Date : 2024-03-11 Hiam Chemaitelly, Houssein H. Ayoub, Patrick Tang, Hadi M. Yassine, Asmaa A. Al Thani, Mohammad R. Hasan, Peter Coyle, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F. Abdul-Rahim, Gheyath K. Nasrallah, Mohamed Ghaith Al-Kuwari, Adeel A. Butt, Hamad Eid Al-Romaihi, Mohamed H. Al-Thani, Abdullatif Al-Khal, Roberto Bertollini
IntroductionReinfections are increasingly becoming a feature in the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, accurately defining reinfection poses methodological challenges. Conventionally, reinfection is defined as a positive test occurring at least 90 days after a previous infection diagnosis. Yet, this extended time window may lead to an underestimation
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Is the cost of the new home dialysis techniques still advantageous compared to in-center hemodialysis? An Italian single center analysis and comparison with experiences from western countries Front. Med. (IF 3.9) Pub Date : 2024-03-11 Gian Maria Iadarola, Elisa Giorda, Marco Borca, Daniela Morero, Savino Sciascia, Dario Roccatello
IntroductionPotential advantages of home dialysis remained a questionable issue. Three main factors have to be considered: the progressive reduction in the cost of consumables for in-Center hemodialysis (IC-HD), the widespread use of incremental Peritoneal Dialysis (PD), and the renewed interest in home hemodialysis (H-HD) in the pandemic era. Registries data on prevalence of dialysis modalities generally
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Development and validation of a prediction score for failure to casirivimab/imdevimab in hospitalized patients with COVID-19 pneumonia Front. Med. (IF 3.9) Pub Date : 2024-03-11 Alessandro Cozzi-Lepri, Vanni Borghi, Salvatore Rotundo, Bianca Mariani, Anna Ferrari, Cosmo Del Borgo, Francesca Bai, Pietro Colletti, Piermauro Miraglia, Carlo Torti, Anna Maria Cattelan, Giovanni Cenderello, Marco Berruti, Carlo Tascini, Giustino Parruti, Simona Coladonato, Andrea Gori, Giulia Marchetti, Miriam Lichtner, Luigi Coppola, Chiara Sorace, Alessandra D'Abramo, Valentina Mazzotta, Giovanni
IntroductionCasirivimab and imdevimab (CAS/IMV) are two non-competing, high-affinity human IgG1 anti-SARS-CoV-2 monoclonal antibodies, that showed a survival benefit in seronegative hospitalized patients with COVID-19. This study aimed to estimate the day-28 risk of mechanical ventilation (MV) and death in individuals hospitalized for severe COVID-19 pneumonia and receiving CAS/IMV. Additionally, it
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Retention rate of biologic and targeted synthetic anti-rheumatic drugs in elderly rheumatoid arthritis patients: data from GISEA registry Front. Med. (IF 3.9) Pub Date : 2024-03-11 Andreina Manfredi, Marco Fornaro, Chiara Bazzani, Simone Perniola, Alberto Cauli, Alessandra Rai, Ennio Giulio Favalli, Serena Bugatti, Maurizio Rossini, Rosario Foti, Fabrizio Conti, Giuseppe Lopalco, Anna Scalvini, Cristina Garufi, Mattia Congia, Roberto Gorla, Elisa Gremese, Fabiola Atzeni, Roberto Caporali, Florenzo Iannone, Marco Sebastiani
ObjectivesAn increased number of elderly individuals affected by rheumatoid arthritis (RA) has been reported, including both patients with RA onset in advanced age and patients aged with the disease. In this registry-based study, we aimed to analyze the retention rate and cause of discontinuation of biologic (b) and targeted synthetic (ts)-disease-modifying anti-rheumatic drugs (DMARDs) in RA patients
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The perilous consequences of bowel preparation: a case study with literature review of Boerhaave syndrome Front. Med. (IF 3.9) Pub Date : 2024-03-11 Ruo-yu Gao, Xiao-lan Wei, Jin-feng Wu, Zhi-wei Zhou, Xi-qiu Yu
Colonoscopy is widely acknowledged as a prevalent and efficacious approach for the diagnosis and treatment of gastrointestinal disorders. In order to guarantee an effective colonoscopy, it is imperative for patients to undergo an optimal bowel preparation regimen. This entails the consumption of a substantial volume of a non-absorbable solution to comprehensively purge the colon of any fecal residue
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Diagnostic accuracy of oral swab for detection of pulmonary tuberculosis: a systematic review and meta-analysis Front. Med. (IF 3.9) Pub Date : 2024-03-11 Fuzhen Zhang, Yilin Wang, Xuxia Zhang, Kewei Liu, Yuanyuan Shang, Wei Wang, Yuanyuan Liu, Liang Li, Yu Pang
ObjectivesTuberculosis (TB) remains a significant concern in terms of public health, necessitating the timely and accurate diagnosis to impede its advancement. The utilization of oral swab analysis (OSA) presents a promising approach for diagnosing pulmonary TB by identifying Mycobacterium tuberculosis (MTB) within oral epithelial cells. Due to disparities in the diagnostic performance of OSA reported
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Ultrasound radiomics-based artificial intelligence model to assist in the differential diagnosis of ovarian endometrioma and ovarian dermoid cyst Front. Med. (IF 3.9) Pub Date : 2024-03-08 Lu Liu, Wenjun Cai, Chenyang Zhou, Hongyan Tian, Beibei Wu, Jing Zhang, Guanghui Yue, Yi Hao
BackgroundAccurately differentiating between ovarian endometrioma and ovarian dermoid cyst is of clinical significance. However, the ultrasound appearance of these two diseases is variable, occasionally causing confusion and overlap with each other. This study aimed to develop a diagnostic classification model based on ultrasound radiomics to intelligently distinguish and diagnose the two diseases
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Efficacy and safety of a music-therapy facilitated pulmonary telerehabilitation program in COPD patients: the COPDMELODY study protocol Front. Med. (IF 3.9) Pub Date : 2024-03-08 Minghui Shi, Lulu Yang, Shiwei Qumu, Jieping Lei, Ke Huang, Ruoxi He, Hongtao Niu, Fen Dong, Siyuan Wang, Jiaze He, Ting Yang
Despite considerable evidence for the benefit in chronic obstructive pulmonary disease (COPD), the implementation of pulmonary rehabilitation (PR) is insufficient. However, music therapy may help address this gap due to its unique benefits. Therefore, we aimed to develop a music-therapy facilitated pulmonary telerehabilitation program based on rhythm-guided walking, singing, and objective telemonitoring
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Case report: Neglected subacute thyroiditis: a case following COVID-19 vaccination Front. Med. (IF 3.9) Pub Date : 2024-03-08 Shuai Yang, Ting Guan, HuanYi Yang, YiRong Hu, Yan Zhao
We report a case of overlooked Subacute Thyroiditis (SAT) potentially induced by the administration of a COVID-19 vaccine. This case prompted a thorough review of the existing literature to elucidate possible mechanisms by which immune responses to the COVID-19 vaccine might precipitate thyroid damage. The primary objective is to enhance the clinical understanding and awareness of SAT among healthcare
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The potential role of artificial intelligence in the clinical management of Hansen’s disease (leprosy) Front. Med. (IF 3.9) Pub Date : 2024-03-08 Patrícia D. Deps, Rie Yotsu, Brunna C. R. S. Furriel, Bruno D. de Oliveira, Sergio L. de Lima, Rafael M. Loureiro
Missed and delayed diagnoses of Hansen’s disease (HD) are making the battle against it even more complex, increasing its transmission and significantly impacting those affected and their families. This strains public health systems and raises the risk of lifelong impairments and disabilities. Worryingly, the three countries most affected by HD witnessed a growth in new cases in 2022, jeopardizing the
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Case report: Treatment of two cases of recurrent/refractory early T-cell precursor acute lymphoblastic leukemia with venetoclax combined with the CAG regimen Front. Med. (IF 3.9) Pub Date : 2024-03-08 Yuxia Jiang, Lin Ji, Xin Jin, Haiying Wu, Mingxia He, Fenglin Shen, Xiaofeng Xu, Huifang Jiang
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a highly aggressive subtype of T-ALL. No standard chemotherapy regimen exists for patients with recurrent/refractory (R/R) ETP-ALL; in these patients, the primary goal of salvage therapy is to achieve remission as a foundation for consolidation and intensification treatments. This study reports cases of two patients with R/R ETP-ALL who
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An overview of case reports and case series of pulmonary actinomycosis mimicking lung cancer: a scoping review Front. Med. (IF 3.9) Pub Date : 2024-03-07 Amin Khoshbayan, Nour Amirmozafari, Shiva Mirkalantari
BackgroundPulmonary actinomycosis (PA) is a rare type of Actinomyces infection that can be challenging to diagnose since it often mimics lung cancer.MethodsPublished case reports and case series of PA in patients with suspicion of lung cancer were considered, and data were extracted by a structured search through PubMed/Medline.ResultsAfter analyzing Medline, 31 studies were reviewed, from which 48
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Patient listening on social media for patient-focused drug development: a synthesis of considerations from patients, industry and regulators Front. Med. (IF 3.9) Pub Date : 2024-03-07 Philipp Cimiano, Ben Collins, Maria Carmela De Vuono, Thierry Escudier, Jürgen Gottowik, Matthias Hartung, Mathias Leddin, Bikalpa Neupane, Raul Rodriguez-Esteban, Ana Lucia Schmidt, Cornelius Starke-Knäusel, Maarten Voorhaar, Krzysztof Wieckowski
Patients, life science industry and regulatory authorities are united in their goal to reduce the disease burden of patients by closing remaining unmet needs. Patients have, however, not always been systematically and consistently involved in the drug development process. Recognizing this gap, regulatory bodies worldwide have initiated patient-focused drug development (PFDD) initiatives to foster a
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Advantages of Chinese herbal medicine in treating rheumatoid arthritis: a focus on its anti-inflammatory and anti-oxidative effects Front. Med. (IF 3.9) Pub Date : 2024-03-07 Xiaoyu Wang, Youqian Kong, Zeguang Li
Oxidative stress is a condition characterized by an imbalance between the oxidative and antioxidant processes within the human body. Rheumatoid arthritis (RA) is significantly influenced by the presence of oxidative stress, which acts as a pivotal factor in its pathogenesis. Elevated levels of mitochondrial reactive oxygen species (ROS) and inflammation have been found to be closely associated in the
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Effects of different treatments on metabolic syndrome in patients with obstructive sleep apnea: a meta-analysis Front. Med. (IF 3.9) Pub Date : 2024-03-07 Jianing Liu, Jiahuan Xu, Shibo Guan, Wei Wang
BackgroundObstructive sleep apnea (OSA) and metabolic syndrome (MetS) often coexist, and the causal relationship between them is not yet clear; treatments for OSA include continuous positive airway pressure (CPAP), mandibular advancement device (MAD), surgery, and lifestyle intervention and so on. However, the effects of different treatments on metabolic syndrome in OSA patients are still under debate
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Hearing impairment in systemic sclerosis patients—what do we really know? Front. Med. (IF 3.9) Pub Date : 2024-03-06 Michał Sieśkiewicz, Damian Rębacz, Andrzej Sieśkiewicz
Background Systemic sclerosis (SSc) is a disease of a very heterogeneous clinical picture and immunological profile with progression rate that varies between individuals. Although hearing deterioration is not a complaint that comes to the fore in SSc patients, as it is not life-threatening compared to many other more severe symptoms of this disease, it can significantly impair the quality of life.
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Enhancing accessibility for improved diagnosis with modified EfficientNetV2-S and cyclic learning rate strategy in women with disabilities and breast cancer Front. Med. (IF 3.9) Pub Date : 2024-03-06 Moteeb Al Moteri, T. R. Mahesh, Arastu Thakur, V. Vinoth Kumar, Surbhi Bhatia Khan, Mohammed Alojail
Breast cancer, a prevalent cancer among women worldwide, necessitates precise and prompt detection for successful treatment. While conventional histopathological examination is the benchmark, it is a lengthy process and prone to variations among different observers. Employing machine learning to automate the diagnosis of breast cancer presents a viable option, striving to improve both precision and
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Non-adherence to anti-tuberculosis treatment and associated factors among TB patients in public health facilities of Hossana town, Southern Ethiopia, 2022 Front. Med. (IF 3.9) Pub Date : 2024-03-06 Lire Lemma Tirore, Tadele Ersido, Tilahun Beyene Handiso, Abriham Shiferaw Areba
BackgroundNon-adherence to anti-tuberculosis treatment is one of the crucial challenges to improving TB treatment outcomes and reducing healthcare costs. The prevalence of non-adherence to anti-tuberculosis treatment is not well documented in the study context. Therefore, this study was aimed at estimating the prevalence of non-adherence to anti-tuberculosis treatment and associated factors among TB
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The collateral damage of the COVID-19 pandemic on homeless people in the Netherlands; a qualitative study on the impact of health and care Front. Med. (IF 3.9) Pub Date : 2024-03-06 Tessa van Loenen, Jeyna Sow, Maria van den Muijsenbergh
IntroductionPeople experiencing homelessness, also in the Netherlands, experience poorer physical and mental health compared to the general population and suffer from unmet health needs that are strongly related to their unfavorable social situation. This makes them especially vulnerable to negative consequences of a public health emergency such as the COVID-19 pandemic. This qualitative study aims
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Spirometry test values can be estimated from a single chest radiograph Front. Med. (IF 3.9) Pub Date : 2024-03-06 Akifumi Yoshida, Chiharu Kai, Hitoshi Futamura, Kunihiko Oochi, Satoshi Kondo, Ikumi Sato, Satoshi Kasai
IntroductionPhysical measurements of expiratory flow volume and speed can be obtained using spirometry. These measurements have been used for the diagnosis and risk assessment of chronic obstructive pulmonary disease and play a crucial role in delivering early care. However, spirometry is not performed frequently in routine clinical practice, thereby hindering the early detection of pulmonary function
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Effects of secukinumab and ixekizumab on major adverse cardiovascular events in patients with psoriasis: a meta-analysis of randomized controlled trials Front. Med. (IF 3.9) Pub Date : 2024-03-06 Yonghong Zhang, Zhiya Yang, Jinyan Gong, Dongmei Shi
IntroductionThe aims of this study is to analyze the risk of major adverse cardiovascular events (MACEs) in patients with psoriasis treated with secukinumab and ixekizumab.MethodologyWe systematically identified randomized controlled trials (RCTs) that focused on the treatment of psoriasis with secukinumab and ixekizumab by conducting computerized searches of PubMed, Embase, and the Cochrane Library
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Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults Front. Med. (IF 3.9) Pub Date : 2024-03-06 Reshma Aziz Merchant, Yiong Huak Chan, Denishkrshna Anbarasan, Bruno Vellas
BackgroundDecline in intrinsic capacity (IC) has been shown to accelerate progression to disability. The study aims to explore association of IC composite score with functional ability, sarcopenia and systemic inflammation in pre-frail older adults.MethodsCross-sectional study of pre-frail older adults ≥60 years old recruited from the community and primary care centers. Composite scores of four domains
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Evaluation of serum and urine biomarkers for severe COVID-19 Front. Med. (IF 3.9) Pub Date : 2024-03-06 Yaroslav D. Shansky, Oleg O. Yanushevich, Alina V. Gospodarik, Igor V. Maev, Natella I. Krikheli, Oleg V. Levchenko, Andrew V. Zaborovsky, Vladimir V. Evdokimov, Alexander A. Solodov, Petr A. Bely, Dmitry N. Andreev, Anna N. Serkina, Sulejman S. Esiev, Anastacia V. Komarova, Philip S. Sokolov, Aleksei K. Fomenko, Mikhail K. Devkota, Sergei V. Tsaregorodtsev, Julia A. Bespyatykh
IntroductionThe new coronavirus disease, COVID-19, poses complex challenges exacerbated by several factors, with respiratory tissue lesions being notably significant among them. Consequently, there is a pressing need to identify informative biological markers that can indicate the severity of the disease. Several studies have highlighted the involvement of proteins such as APOA1, XPNPEP2, ORP150, CUBN
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Exploring the divergence in perspectives on clinical trial operations in South Korea during the COVID-19 pandemic: a comparison of a trial site and sponsors Front. Med. (IF 3.9) Pub Date : 2024-03-06 Young-Sang Kim, Anhye Kim, Yil-Seob Lee
IntroductionDuring the COVID-19 pandemic, novel clinical trial methods known as decentralized clinical trials (DCTs) were rapidly introduced. The attitude toward operating clinical trials and perspectives on DCTs may differ between clinical trial sites and sponsors. The impact of the COVID-19 pandemic on clinical trials was investigated for a society of sponsors and a trial site in South Korea.MethodsThe
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Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis Front. Med. (IF 3.9) Pub Date : 2024-03-06 Natasha de Zoysa, Kotaro Haruhara, David J. Nikolic-Paterson, Peter G. Kerr, Jonathan Ling, Sarah E. Gazzard, Victor G. Puelles, John F. Bertram, Luise A. Cullen-McEwen
Corticosteroid therapy, often in combination with inhibition of the renin-angiotensin system, is first-line therapy for primary focal and segmental glomerulosclerosis (FSGS) with nephrotic-range proteinuria. However, the response to treatment is variable, and therefore new approaches to indicate the response to therapy are required. Podocyte depletion is a hallmark of early FSGS, and here we investigated
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Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis Front. Med. (IF 3.9) Pub Date : 2024-03-06 Andrea Olguín-Ortega, Ricardo Figueroa-Damian, Martha Leticia Palafox-Vargas, Enrique Reyes-Muñoz
IntroductionHistologic chorioamnionitis (HCA) is a placental inflammatory condition associated with adverse perinatal outcomes (APOs). This historical cohort study explores the risk of APOs in pregnant women with HCA and compares the impact of clinical chorioamnionitis (CCA) with subclinical chorioamnionitis (SCCA).MethodologyPlacentas were evaluated by a perinatal pathologist tand all women with HCA
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Antimicrobial treatment in invasive infections caused by Gordonia bronchialis: systematic review Front. Med. (IF 3.9) Pub Date : 2024-03-06 Radica Zivkovic Zaric, Petar Canovic, Milan Zaric, Marko Vuleta, Katarina Vuleta Nedic, Jovan Jovanovic, Nenad Zornic, Jelena Nesic, Marko Spasic, Stefan Jakovljevic, Milena Ilic, Dalibor Jovanovic, Zeljko Todorovic, Petar Arsenijevic, Miroslav Sovrlic, Jasmina Milovanovic
BackgroundCorynebacterium, Nocardia, Rhodococcus, Mycobacterium, as well as Gordonia genera belongs to the genus Gordonia, Actinomycetia class. Gordonia bronchialis is a nitrate-reducing, urease-producing, non-motile, force aerobe with a rod-like figure that is known to arrangement into sessile, cord-like groups. This systematic review aimed to establish whether and what invasive infections in humans
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The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population—A comparison of two German registries Front. Med. (IF 3.9) Pub Date : 2024-03-06 Rebecca Hasseli, Frank Hanses, Melanie Stecher, Christof Specker, Tobias Weise, Stefan Borgmann, Martina Hasselberger, Bernd Hertenstein, Martin Hower, Bimba F. Hoyer, Carolin Koll, Andreas Krause, Marie von Lilienfeld-Toal, Hanns-Martin Lorenz, Uta Merle, Susana M. Nunes de Miranda, Mathias W. Pletz, Anne C. Regierer, Jutta G. Richter, Siegbert Rieg, Christoph Roemmele, Maria M. Ruethrich, Tim Schmeiser
ObjectivesTo investigate, whether inflammatory rheumatic diseases (IRD) inpatients are at higher risk to develop a severe course of SARS-CoV-2 infections compared to the general population, data from the German COVID-19 registry for IRD patients and data from the Lean European Survey on SARS-CoV-2 (LEOSS) infected patients covering inpatients from the general population with SARS-CoV-2 infections were
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Esophageal cancer detection via non-contrast CT and deep learning Front. Med. (IF 3.9) Pub Date : 2024-03-06 Chong Lin, Yi Guo, Xu Huang, Shengxiang Rao, Jianjun Zhou
BackgroundEsophageal cancer is the seventh most frequently diagnosed cancer with a high mortality rate and the sixth leading cause of cancer deaths in the world. Early detection of esophageal cancer is very vital for the patients. Traditionally, contrast computed tomography (CT) was used to detect esophageal carcinomas, but with the development of deep learning (DL) technology, it may now be possible
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Long-term reduced functional capacity and quality of life in hospitalized COVID-19 patients Front. Med. (IF 3.9) Pub Date : 2024-03-06 Anderson Donelli da Silveira, Fernando Luis Scolari, Marina Petersen Saadi, Darshan H. Brahmbhatt, Mauricio Milani, Juliana Goulart Prata Oliveira Milani, Gerson Cipriano Junior, Ivaine Tais Sauthier Sartor, Gabriela Oliveira Zavaglia, Maiko Luis Tonini, Marcela Santos Correa da Costa, Marcelo Comerlato Scotta, Renato T. Stein, Regis Goulart Rosa
BackgroundPersistent symptoms and exercise intolerance have been reported after COVID-19, even months after the acute disease. Although, the long-term impact on exercise capacity and health-related quality of life (HRQoL) is still unclear.Research questionTo assess the long-term functional capacity and HRQoL in patients hospitalized due to COVID-19.Study design and methodsThis is a prospective cohort
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Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study Front. Med. (IF 3.9) Pub Date : 2024-03-05 Wang Xiaowu, Zhou Qiang, Han Yike, Zhixuan Wu, Jin Yiheng, Chen Xuemei, Lin Sen, Chen Jiong
PurposeIn recent years, the relationship between malignant tumors and atrial fibrillation has attracted more and more attention. Atrial fibrillation can also cause a series of adverse events, such as the risk of thromboembolism. Also, Warfarin is often used here. But, the relationship between cutaneous melanoma and atrial fibrillation, and between cutaneous melanoma and warfarin is still unclear. Therefore
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Robotic surgery for deep-infiltrating endometriosis: is it time to take a step forward? Front. Med. (IF 3.9) Pub Date : 2024-03-05 Filippo Alberto Ferrari, Youssef Youssef, Antoine Naem, Federico Ferrari, Franco Odicino, Harald Krentel, Gaby Moawad
Endometriosis is a chronic debilitating disease that affects nearly 10% of women of the reproductive age. Although the treatment modalities of endometriosis are numerous, surgical excision of the endometriotic implants and nodules remains the sole cytoreductive approach. Laparoscopic excision of endometriosis was proven to be beneficial in improving the postoperative pain and fertility. Moreover, it
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Development and validation of a predictive model for stroke associated pneumonia in patients after thrombectomy for acute ischemic stroke Front. Med. (IF 3.9) Pub Date : 2024-03-05 Jingying Wang, Chao Yang, Ruihai Zhang, Wei Hu, Peng Yang, Yiqing Jiang, Weijun Hong, Renfei Shan, Yongpo Jiang
ObjectiveThis study aims to identify the risk factors associated with stroke-associated pneumonia (SAP) in patients who have undergone thrombectomy for acute ischemic stroke and to develop a nomogram chart model for predicting the occurrence of pneumonia.MethodsConsecutive patients who underwent thrombectomy for acute ischemic stroke were enrolled from three hospitals at Taizhou Enze Medical Center
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Development and implementation of a high-fidelity simulation training course for medical and nursing collaboration based on the Fink integrated course design model Front. Med. (IF 3.9) Pub Date : 2024-03-05 Meng-Han Jiang, Li-Wen Dou, Bo Dong, Man Zhang, Yue-Ping Li, Cui-Xia Lin
AimThe purpose of this study is to examine the design and implementation of a high-fidelity simulation training course for medical and nursing collaboration, based on the Fink integrated course design model. Additionally, the study aims to validate the teaching effectiveness of the course.BackgroundPrevious empirical studies have highlighted the effectiveness of collaborative healthcare education in
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Post-operative sepsis-induced acute respiratory distress syndrome: risk factors for a life-threatening complication Front. Med. (IF 3.9) Pub Date : 2024-03-05 Miguel Bardají-Carrillo, Marta Martín-Fernández, Rocío López-Herrero, Juan Manuel Priede-Vimbela, María Heredia-Rodríguez, Esther Gómez-Sánchez, Estefanía Gómez-Pesquera, Mario Lorenzo-López, Pablo Jorge-Monjas, Rodrigo Poves-Álvarez, Jesús Villar, Eduardo Tamayo
IntroductionPrevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis and major surgery are conditions associated with ARDS. We aimed to examine the impact of post-operative sepsis-induced ARDS on 60-day mortality.MethodsWe performed a secondary
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The association between chronic obstructive pulmonary disease and autoimmune diseases: a bidirectional Mendelian randomization study Front. Med. (IF 3.9) Pub Date : 2024-03-05 Xiaohui Yu, Xue Cheng, Lin Lv, Na Wang, Mengcong Li, Wenwen Ji, Tingting Liu, Guangdong Wang, Tinghua Hu, Zhihong Shi
ObjectiveObservational studies have reported that chronic obstructive pulmonary disease (COPD) is often accompanied by autoimmune diseases, but the causal relationships between them remain uncertain. In this Mendelian study, we aimed to investigate the potential causal relationship between COPD and four common autoimmune diseases.MethodsWe conducted an analysis of summary data on COPD and autoimmune
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Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report Front. Med. (IF 3.9) Pub Date : 2024-03-05 Antonio Maiorano, Chiara Lupia, Nicola Montenegro, Giuseppe Neri, Andrea Bruni, Eugenio Garofalo, Federico Longhini, Claudia Crimi, Angelantonio Maglio, Alessandro Vatrella, Girolamo Pelaia, Corrado Pelaia
Beclomethasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) single inhaler extrafine triple therapy is effective for the treatment of uncontrolled asthma. Nevertheless, there is a lack of data about the use of diaphragmatic ultrasonography to monitor adult asthmatics while they are receiving inhaled treatment. We took into consideration a 78-year-old woman complaining of asthma, treated
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A phase I clinical trial assessing the safety, tolerability, and pharmacokinetics of inhaled ethanol in humans as a potential treatment for respiratory tract infections Front. Med. (IF 3.9) Pub Date : 2024-03-05 David G. Hancock, William Ditcham, Eleanor Ferguson, Yuliya V. Karpievitch, Stephen M. Stick, Grant W. Waterer, Barry S. Clements
BackgroundCurrent treatments for respiratory infections are severely limited. Ethanol’s unique properties including antimicrobial, immunomodulatory, and surfactant-like activity make it a promising candidate treatment for respiratory infections if it can be delivered safely to the airway by inhalation. Here, we explore the safety, tolerability, and pharmacokinetics of inhaled ethanol in a phase I clinical