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Long-term outcomes, residual symptoms and quality of life in COVID-19 hospitalized patients: A 12-month longitudinal study. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-29 Aspasia Manta,Ioannis Michelakis,Maria Dafni,Anastasia Spanoudaki,Sofia Krontira,Theodoros Tsoutsouras,Konstantina Flessa,Constantinos Papadopoulos,Dionysios Mantzos,Vasiliki Tzavara
The long-term impact of the coronavirus disease 2019 (COVID-19) pandemic is a critical public health concern. The presence of residual symptoms in COVID-19 survivors has been investigated with various results; however, there is limited data documenting outcomes longer than 6 months post-hospitalization. We aimed to investigate the 12-month lasting effects of COVID-19 in hospitalized patients. From
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EXPRESS: Cannabinoid Hyperemesis Syndrome: Prevalence and Management in an Era of Cannabis Legalization. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-23 Justin Joe Stubbs,Richard McCallum
As more states legalize cannabinoid products for recreational use and medicinal purposes the prevalence of cannabinoid hyperemesis syndrome has become increasingly common. Yet, it remains unrecognized to many healthcare providers along with the most efficacious treatments. Cannabinoid hyperemesis syndrome most often presents with episodic vomiting secondary to chronic daily cannabis use over several
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The spectrum of gastrointestinal functional bowel disorders in joint hypermobility syndrome and in an academic referral center. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-18 Priyadarshini Loganathan,Daniel Herlihy,Mahesh Gajendran,Zorisadday Gonzalez,Luis O Chavez,Karina Espino,Richard W McCallum
Joint hypermobility syndrome (JHS) is a non-inflammatory hereditary disorder of connective tissue with varied clinical presentations, including frequent joint dislocations, hyperextensible skin, easy bruising, and abnormal paper-thin scar formation. Many of these patients have unexplained gastrointestinal (GI) symptoms. Our aim was to evaluate the prevalence of JHS in a tertiary gastroenterology motility
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Cholesterol deficiency as a mechanism for autism: a valproic acid model. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-18 Morgan R Peltier,Jennifer Behbodikhah,Heather A Renna,Saba Ahmed,Ankita Srivastava,Yuko Arita,Lora J Kasselman,Aaron Pinkhasov,Thomas Wisniewski,Joshua De Leon,Allison B Reiss
Dysregulated cholesterol metabolism represents an increasingly recognized feature of autism spectrum disorder (ASD). Children with fetal valproate syndrome caused by prenatal exposure to valproic acid (VPA), an anti-epileptic and mood-stabilizing drug, have a higher incidence of developing ASD. However, the role of VPA in cholesterol homeostasis in neurons and microglial cells remains unclear. Therefore
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Rapid qPCR-based quantitative immune cell phenotyping in mouse tissues. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-12 Jinghao Huang,Richard Demmler,Mariam Mohamed Abdou,Oana-Maria Thoma,Benno Weigmann,Maximilian J Waldner,Michael Stürzl,Elisabeth Naschberger
The immune microenvironment plays an important role in the regulation of diseases. The characterization of the cellular composition of immune cell infiltrates in diseases and respective models is a major task in pathogenesis research and diagnostics. For the assessment of immune cell populations in tissues, fluorescence-activated cell sorting (FACS) or immunohistochemistry (IHC) are the two most common
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Can the generalizability issue of artificial intelligence be overcome? Pneumothorax detection algorithm. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-10 Elvan Burak Verdi,Muhammed Yılmaz,Deniz Doğan Mülazimoğlu,Abdussamet Türker,Aslıhan Gürün Kaya,Özlem Işık,Aslı Bostanoğlu Karaçin,Övgü Velioğlu Yakut,Bülent Mustafa Yenigün,Çağlar Uzun,Atilla Halil Elhan,Özlem Özdemir Kumbasar,Akın Kaya,Ayten Kayı Cangır,Cantürk Taşçı,Ahmet Murat Özbayoğlu,Serhat Erol
The generalizability of artificial intelligence (AI) models is a major issue in the field of AI applications. Therefore, we aimed to overcome the generalizability problem of an AI model developed for a particular center for pneumothorax detection using a small dataset for external validation. Chest radiographs of patients diagnosed with pneumothorax (n = 648) and those without pneumothorax (n = 650)
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Atrial fibrillation mortality trends in individuals with heart failure. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-10 Ramzi Ibrahim,Vikram J Singh,Simar J Singh,Ayman Hussein,Justin Z Lee
Atrial fibrillation (AF) frequently occurs concurrently with heart failure (HF). The two conditions can exacerbate each other, resulting in higher morbidity and mortality. In our analysis, we evaluated mortality trends related to AF in individuals with underlying HF. Cross-sectional analyses were performed using publicly available data from the Center for Disease Control and Prevention database to
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Association of MIF-173G/C, IL-4 VNTR, and IL-1RA VNTR variants with FMF-related amyloidosis in a Turkish cohort. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-10 Serbulent Yigit,Ayse Feyda Nursal,Adem Keskin,Suheyla Kaya,Nilufer Kuruca,Ozlem Sezer
The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis. The aim of this study is to investigate the risk of developing FMF-related amyloidosis with macrophage migration inhibitory factor (MIF), interleukin 4 (IL-4), and IL-1 receptor antagonist (IL-1RA) variants. This study included 62 FMF patients with amyloidosis, 110 FMF patients without amyloidosis, and 120
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Clinical predictions of COVID-19 patients using deep stacking neural networks. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-10 Sajid Hussain,Xu Songhua,Muhammad Usman Aslam,Fida Hussain
The coronavirus disease 2019 (COVID-19) pandemic, which emerged in late 2019, has caused millions of infections and fatalities globally, disrupting various aspects of human society, including socioeconomic, political, and educational systems. One of the key challenges during the COVID-19 pandemic is accurately predicting the clinical development and outcome of the infected patients. In response, scientists
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FK-binding protein 5: possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-09 Jing Ma,Zhihong Yang,Hui Gao,Nazmul Huda,Yanchao Jiang,Suthat Liangpunsakul
The FK506-binding protein (FKBP5) plays significant roles in mediating stress responses by interacting with glucocorticoids, participating in adipogenesis, and influencing various cellular pathways throughout the body. In this review, we described the potential role of FKBP5 in the pathogenesis of two common chronic liver diseases, metabolic dysfunction-associated steatotic liver disease (MASLD), and
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Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway. J. Investig. Med. (IF 2.6) Pub Date : 2023-10-31 Guangkui Bu,Gang Chen,Juan Li,Dan Wu,Jiangtao Liao
Metabolic dysfunction-associated fatty liver disease (MAFLD) is strongly associated with disturbances in the intestinal microbiota. Herein, the biological effects and mechanism of Bifidobacterium bifidum BGN4 fractions in regulating hepatocyte ferroptosis during MAFLD progression were investigated. To establish an in vitro model of MAFLD, LO2 cells were subjected to palmitic acid (PA). The mRNA and
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Effects of prehabilitation resistance training in mild to moderate clinically frail patients awaiting coronary artery bypass graft surgery. J. Investig. Med. (IF 2.6) Pub Date : 2023-10-30 Wajeeha Sahar,Mehwish Waseem,Muhammad Riaz,Nouman Nazeer,Muhammad Ahmad,Zulfiqar Haider
Coronary artery disease is one of the main causes of mortality and morbidity among chronic heart diseases worldwide. Patients reported chronic chest pain as the primary symptom of coronary artery disease. Due to its progressive nature, it affects the health status and functional capacity of the patients. The current study was planned to compare the effects of prehabilitation resistance training in
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Public health initiatives: addressing social vulnerability in research and practice. J. Investig. Med. (IF 2.6) Pub Date : 2023-10-28 Ramzi Ibrahim,Enkhtsogt Sainbayar,Hoang Nhat Pham
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Families with non-Hodgkin lymphoma and plasma cell dyscrasias in their pedigrees. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-28 Peter H Wiernik,Janice P Dutcher
Although reports of familial clustering of hematologic malignancies have appeared for decades, the cause(s) of this uncommon occurrence is still not completely understood. Most modern investigations, however, support a genetic rather than an environmental exposure as a cause of this observation. Most pedigrees of families with familial hematologic malignancies demonstrate age of onset anticipation
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Colonoscopy in the young: An indication-based analysis of outcome. J. Investig. Med. (IF 2.6) Pub Date : 2023-10-20 Fadi Abu Baker,Ahmad Samhat,Randa Taher Natour,Abdel-Rauf Zeina,Yael Kopelman
BACKGROUND Data on colonoscopy's diagnostic yield in young adults with lower gastrointestinal symptoms are scarce. We evaluated this yield in young patients by performing an indication-based analysis of outcomes. METHODS We reviewed diagnostic colonoscopies performed in young adults (age <50 years) over 10 years. We created two groups of young adults (18-39 years, n = 4941) and quadragenarians (40-49 years;
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Association between monocyte to high-density lipoprotein-cholesterol ratio and osteoporosis: an analysis of the National Health and Nutrition Examination Survey 2013-2014. J. Investig. Med. (IF 2.6) Pub Date : 2023-10-18 Fushan Zhou,Liyong Wu,Guizhou Shen,Xintan Chen,Chaoyang Liu,Dongqin Huang,Mingmei Li,Chengwei Xie,Ruyu Zhan
The monocyte to high-density lipoprotein-cholesterol (HDL-C) ratio (monocyte-to-HDL-C ratio) was proposed as a marker of atherosclerosis. Osteoporosis and atherosclerosis share common risk factors and pathophysiological mechanisms. This study aimed to assess the relationship between monocyte-to-HDL-C ratio and osteoporosis. Participants aged ≥50 years with complete bone mineral density (BMD), monocyte
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GANT61, an inhibitor of Gli1, inhibits the proliferation and migration of hepatocellular carcinoma cells. J. Investig. Med. (IF 2.6) Pub Date : 2023-10-09 Bao-Wang Liu,Jing-Lin Cao,Yang Wang,Xin Zhao,Qiang Zeng,Wen-Peng Liu,Jun-Hong Zhang,Yi-Ze Fan,Jian Dou
Constitutive activation of Hedgehog (Hh) signaling has been implicated in many cancers including hepatocellular carcinoma (HCC). Among them, the terminal glioma-associated oncogene homolog 1 (Gli1) regulates the expression of critical genes in the Hh pathway. The current study aims to evaluate the anti-HCC effect of the Gli1 inhibitor, GANT61. In vitro analysis including cell counting kit-8 (CCK-8)
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EXPRESS: Integrin α2 promotes immune escape in non-small cell lung cancer by enhancing PD-L1 expression in exosomes to inhibit CD8+T cell activity. J. Investig. Med. (IF 2.6) Pub Date : 2023-10-07 Hui Jing,Meng Meng,Mengjie Ye,Shuan Liu,Xubo Cao,Ke Li,Yuanyuan Liu,Jinghao Zhang,Yanmin Wu
This study intended to delineate the mechanism and functional role of Integrin α2(ITGA2) in Non-small cell lung cancer (NSCLC) cell immune escape. Bioinformatics analysis was utilized to analyze ITGA2 expression in NSCLC tissues, and correlations between ITGA2 expression and patient survival time, ITGA2 expression and PD-L1(CD274) expression, and ITGA2 expression and CD8+T cell infiltration. qRT-PCR
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CIAP1/2 can regulate the inflammatory response and lung injury induced by apoptosis in septic rats. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-28 Xiaoyu Liu,Jie Chen,Zhonghao Li,Nan Gao,Guoqiang Zhang
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), induced by sepsis, is predominantly caused by inflammation injury. However, there is no clear consensus on how to regulate the inflammatory response. The TNF pathway is one of the primary inflammatory pathways activated in sepsis. cIAP1/2, an essential E3 ubiquitin ligase in the TNF pathway, plays a pivotal role in positively regulating
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Colonoscopy in the young: Rethinking the yield. J. Investig. Med. (IF 2.6) Pub Date : 2023-09-30 Afif Yaccob,Amir Mari
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COVID-19-related mortality in Texas border counties vs non-border counties. J. Investig. Med. (IF 2.6) Pub Date : 2023-09-29 Amna Obaid,Seyed Khalafi,Alok K Dwivedi,Vishwajeet Singh,Fatma Dihowm
The state of Texas ranked second in total cases of coronavirus disease 2019 (COVID-19) in the United States during the pandemic. Counties near the US-Mexico border were severely impacted by the pandemic. Mortality and long-term consequences from COVID-19 are associated with comorbidities, illness severity, and patient demographics. However, differences in outcomes between border and non-border counties
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Health insurance prevalence and acute pancreatitis mortality: a cross-sectional analysis. J. Investig. Med. (IF 2.6) Pub Date : 2023-09-22 Macklin Loveland,Elise Le Cam,Ramzi Ibrahim,João Paulo Ferreira
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Plasma endocannabinoids and cannabimimetic fatty acid derivatives are altered in cyclic vomiting syndrome: The effects of sham feeding. J. Investig. Med. (IF 2.6) Pub Date : 2023-09-15 Mohammad Bashashati,Heather B Bradshaw,Clare T Johnson,Marc J Zuckerman,Jerzy Sarosiek,Richard W McCallum,Irene Sarosiek
Cyclic vomiting syndrome (CVS) is an underdiagnosed disorder of the gut-brain interaction. Our understanding of the pathophysiology of CVS is evolving. Here, we tested the hypotheses that: (1) the levels of endocannabinoids and related lipids are altered in CVS, and (2) cephalic-vagal stimulation drive changes in endolipid levels. Ten adult patients with CVS and eight healthy controls were included
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Metformin prescription for U.S. veterans with prediabetes, 2010-2019. J. Investig. Med. (IF 2.6) Pub Date : 2023-11-20 Barbara I Gulanski,Joseph L Goulet,Krishnan Radhakrishnan,John Ko,Yuli Li,Nallakkandi Rajeevan,Kyung Min Lee,Kent Heberer,Julie A Lynch,Elani Streja,Pradeep Mutalik,Kei-Hoi Cheung,John Concato,Mei-Chiung Shih,Jennifer S Lee,Mihaela Aslan
Affecting an estimated 88 million Americans, prediabetes increases the risk for developing type 2 diabetes mellitus (T2DM), and independently, cardiovascular disease, retinopathy, nephropathy, and neuropathy. Nevertheless, little is known about the use of metformin for diabetes prevention among patients in the Veterans Health Administration, the largest integrated healthcare system in the U.S. This
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COVID-19 in the intensive care unit: Unmasking the critical factors impacting patient survival. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-31 Bahadar S Srichawla,Jared Quast,Peter Pacut,Shravan Sivakumar,Maria A Garcia-Dominguez,Jillian Belgrad,Ashwin Panda,Sara Carbone,Delia T Sanders,Eli Min,Nicole T Hayes,Abigail Bose,Vanessa Lee,Mehdi Ghasemi
In the midst of the coronavirus disease 2019 (COVID-19) pandemic, intensive care units (ICUs) around the world have been pushed to their limits as they grapple with the effects of the severe acute respiratory syndrome coronavirus 2 virus. Identifying prognostic factors that influence mortality in COVID-19 patients admitted to the ICU could offer valuable insights for clinicians seeking to prevent disease
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Validation of a renal risk score in a cohort of children with ANCA-associated glomerulonephritis. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-24 Pei Zhang,Jun Yao,Chun-Lin Gao,Xiang Fang,Zhi-Qiang Zhang,Zheng-Kun Xia
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is extremely rare in children. Renal involvement is a common and severe complication of AAV as it can cause end stage kidney disease (ESKD). ANCA renal risk score (ARRS) is helpful in predicting long-term ESKD in patients with ANCA-associated glomerulonephritis (AAGN). This retrospective study included 61 consecutive patients with
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Perception of pacifier use among caregivers of infants 0-1 years of age. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-23 Aashika Janwadkar,Genefer Duran,T Deseree Irving,Dhaivat Shah,Ronald Arevalo,Miguel Sanchez,Janine Adjo,David Rubin
American Academy of Pediatrics approves pacifier use for soothing and calming; it recommends delaying its use until breastfeeding is well established. Though pacifiers have protective effects against sudden infant death syndrome, prolonged use of a pacifier can lead to complications. American Academy of Family Physicians discourages the use by 6 months to 1 year of age. Pacifier use guidelines are
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Potential reduction of post-acute sequelae of SARS-CoV-2 symptoms via vaccination. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-23 Greg Vanichkachorn,Elizabeth Gilman,Ravindra Ganesh,Michael Mueller,Melanie Swift,Laura Breeher,M Hassan Murad
The objective of this observational study is to determine whether vaccination for SARS-CoV-2 alters the clinical presentation of post-COVID conditions (PCC). Self-reported data provided by patients requesting care for PCC at the Mayo Clinic were analyzed to assess for a relationship between vaccination status prior to COVID infection and PCC symptoms. In all, 477 subjects were included in this study
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Risk factors for post-acute sequelae of COVID-19: Survey results from a tertiary care hospital. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-12 Bala Munipalli,Yaohua Ma,Zhuo Li,Ravindra Ganesh,Dacre Knight,Ilana I Logvinov,Stefan N Paul,Troy R Delaney,Abd Moain Abu Dabrh
Identifying risk factors for post-acute sequelae of COVID-19 (PASC) is important. We conducted a multicenter cross-sectional survey study to define and characterize risk factors for severe COVID-19 in adults (≥18 years) treated at our virtual COVID-19 clinic from March 1, 2020, through March 31, 2021. We assessed patient demographics, symptom types, and persistence, incidence of PASC, and COVID-19-caused
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Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-09 Huseyin Erdal,Faruk Turgut
This is the first study to show both dynamic thiol-disulfide balance and oxidative stress levels in patients with Fabry disease (FD). This prospective study consists of 30 FD patients and 30 healthy controls. Thiol and disulfide values of the study groups were evaluated using a new, cost-effective and fully automatic colorimetric method. A total of 60 subjects were included in the study. A statistically
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Analysis of risk factors for abdominal aortic calcification in dialysis patients and its influence on long-term recovery. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-07 Qianying Cao,Fan Yang,Xiaoying Lian,Xiangnan Li,Zhongxin Li
This study investigated the risk factors of abdominal aortic calcification (AAC) in patients with stage 5 chronic kidney disease (CKD) and the effects of AAC and different dialysis methods on the 3-year survival rate of patients with stage 5 CKD. A retrospective cohort study was conducted on stage 5 CKD patients who received dialysis treatment. The general data were collected, and all fasting venous
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An innovative approach to comprehensive communication skills training for residents: A resident-led communication curriculum. J. Investig. Med. (IF 2.6) Pub Date : 2023-08-02 Chelsea Hook Chang,Krishna Suri,Rex Huang,Michael Machiorlatti,Mery Bartl,Roque Mifuji
Innovations to enhance residency training in interpersonal and communication skills are needed and a resident-led strategy has not been well-described. In this study, we explored a resident-led comprehensive communication skills curriculum for internal medicine residents. Residents and faculty prepared the curriculum as part of an Accreditation Council for Graduate Medical Education (ACGME) Back to
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Integrating evidence-based medicine into resident education. J. Investig. Med. (IF 2.6) Pub Date : 2023-07-31 Kristina Terrani,Ramzi Ibrahim,Eric Brucks
Evidence-based medicine (EBM) is the practice of applying scientific evidence to clinical decision-making, with a focus on addressing the individualized needs and values of patients. It requires not only a solid foundation of medical knowledge and the ability to gather a thorough patient history but also the skills to locate, interpret, and apply relevant principles from the medical literature. Given
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EXPRESS: Novel Strategies for Chimeric Antigen Receptor T-Cell Therapy for Acute Lymphoblastic Leukemia: Moving Beyond CD19. J. Investig. Med. (IF 2.6) Pub Date : 2023-07-27 Luna Acharya,Alpana Garg,Manoj Rai,Rupesh Kshetri,Udhayvir Singh Grewal,Prajwal Dhakal
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults with a poor prognosis with Relapsed Refractory (RR) B cell lineage ALL (B-ALL). Anti-CD19 Chimeric antigen receptor (CAR) T-cell therapy has shown excellent response rates in RR B-ALL, but most patients relapse due to poor persistence of CAR T-cell therapy or other tumor-associated escape mechanisms. In addition,
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Prediction of overall survival after radical gastrectomy using nomograms created by tumor markers. J. Investig. Med. (IF 2.6) Pub Date : 2023-07-21 Li-Xiang Zhang,Zi-Yi Cao,Hao-Hao Li,Chuan-Hong Li,Ang-Qing Li,Pan-Quan Luo,En-Dong Song,Zhi-Jian Wei,Wen-Xiu Han,Ye-Zhou Su,Long-Ping Ye,A-Man Xu
Prediction of prognosis after radical resection of gastric cancer has not been well established. Therefore, we aimed to establish a prognostic model based on a new score system of patients with gastric cancer. A total of 1235 patients who underwent curative gastrectomy at our hospital from October 2015 to April 2017 were included in this study. Univariate and multivariate analyses were used to screen
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Survival of small-cell lung cancer patients after surgery: A single-center retrospective cohort study. J. Investig. Med. (IF 2.6) Pub Date : 2023-07-10 Zhibo Zheng,Danyang Zhu,Lei Liu,Michael W Chen,Guiping Li,Ruixuan Geng,Ying Zhang,Cheng Huang,Zhenhuan Tian,Hongsheng Liu,Shanqing Li,Yeye Chen
This study summarized and analyzed the clinical characteristics and prognosis of small-cell lung cancer (SCLC) patients after surgical treatment. The clinical data of 130 patients (99 males and 31 females) with SCLC treated by surgery and confirmed by postoperative pathological examination at Peking Union Medical College Hospital from April 2004 to April 2019 were retrospectively analyzed. Clinical
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Harms of third- and fourth-generation combined oral contraceptives in premenopausal women: A systematic review and meta-analysis. J. Investig. Med. (IF 2.6) Pub Date : 2023-07-06 Andrea Flores-Rodriguez,Fernando Diaz Gonzalez-Colmenero,Mariana Garcia-Leal,Melissa Saenz-Flores,Erick Burciaga-Jimenez,Jorge A Zuñiga-Hernandez,Neri A Alvarez-Villalobos,Rene Rodríguez-Guajardo,Felipe A Morales-Martinez,Luis H Sordia-Hernandez,Rene Rodriguez-Gutierrez
We assessed the available evidence regarding adverse effects on surrogate and patient-important health outcomes of third- and fourth-generation combined oral contraceptives among premenopausal women. We performed a systematic review and meta-analysis including randomized controlled trials and observational studies comparing third- and fourth-generation combined oral contraceptives with other generation
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Chronic liver disease is not associated with statin prescription in a primary care cohort. J. Investig. Med. (IF 2.6) Pub Date : 2023-07-03 Joseph A Moore,Andrew D Schreiner,Jingwen Zhang,Patrick Mauldin,William P Moran,David G Koch
Statins have historically been underutilized in patients with chronic liver disease (CLD). We sought to investigate the association between CLD and statin prescription in a primary care setting. Our retrospective cohort study identified primary care patients with a low-density lipoprotein value and more than one office visit from 2012 through 2018. Indication for statin therapy was determined using
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Efficacy and safety of medications for osteoporosis in kidney transplant recipients or patients with chronic kidney disease: A meta-analysis. J. Investig. Med. (IF 2.6) Pub Date : 2023-06-30 Yunji Leng,Xian Yu,Yi Yang,Yifan Xia
This study conducted a meta-analysis to analyze the efficacy and safety of osteoporosis medications in kidney transplant recipients and patients with chronic kidney disease (CKD). PubMed, Embase, the Cochrane Central Register of Controlled Trials were searched from the date of their inception through October 21, 2022. We performed a meta-analysis of the efficacy and safety of osteoporosis medications
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Could endothelial progenitor cells complement the diagnosis of inflammatory arthritis? A systematic review and meta-analysis. J. Investig. Med. (IF 2.6) Pub Date : 2023-06-29 Hui Zhao,Lanlan Fang,Yuting Chen,Yubo Ma,Qiang Zhou,Shengqian Xu,Zongwen Shuai,Guoqi Cai,Faming Pan
The objective of this meta-analysis was to systematically review existing evidence and evaluate variations in levels of circulating endothelial progenitor cells (EPCs) among individuals with psoriatic arthritis (PsA), juvenile idiopathic arthritis (JIA), and rheumatoid arthritis (RA). Relevant studies were identified through database searches, and 20 records were enrolled. We used the fixed-effect
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Increased triglyceride-glucose index predicts contrast-induced nephropathy in non-diabetic NSTEMI patients: A prospective study. J. Investig. Med. (IF 2.6) Pub Date : 2023-06-28 Halil Aktas,Sinan Inci,Murat Gul,Selman Gencer,Oguz Yildirim
The triglyceride-glucose (TyG) index is a new reliable marker of insulin resistance (IR) and has recently been reported to be associated with renal dysfunction and contrast-induced nephropathy (CIN). Our aim in this study is to investigate the relationship between the TyG index and CIN in non-diabetic non-ST elevation acute myocardial infarction (NSTEMI) patients. The study included 272 non-diabetic
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Racial/ethnic disparities in HIV care outcomes among insured patients at a large urban sexual health clinic. J. Investig. Med. (IF 2.6) Pub Date : 2023-06-26 Reanne Mathai,Federico Hinestrosa,Edwin DeJesus,Charlotte-Paige Rolle
Prior studies demonstrate that non-White patients are less likely to achieve human immunodeficiency virus (HIV) suppression compared to White patients due to lack of health insurance. This study aims to determine whether racial disparities in the HIV care cascade persist among a cohort of privately and publicly insured patients. This retrospective analysis evaluated HIV care outcomes during the first
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Development and validation of a simple-to-use nomogram for predicting the delayed radiographic recovery in children with mycoplasma pneumoniae pneumonia complicated with atelectasis. J. Investig. Med. (IF 2.6) Pub Date : 2023-06-02 Yonghan Luo,Jihong Dai,Guojing Tang,Shan He,Wenlong Fu
This study aimed to develop and validate a simple-to-use nomogram for predicting the delayed radiographic recovery in children with mycoplasma pneumoniae pneumonia (MPP) complicated with atelectasis. A retrospective study of 306 children with MPP complicated with atelectasis was performed at the Children's Hospital of Chongqing Medical University from February 2017 to March 2020.The patients were divided
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Relation between erythropoietin resistance and metabolic syndrome in hemodialysis patients: A multicentric propensity score matched analysis. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-18 Essam Kotb,Ismail Mohamed El Mancy,Ibrahim Ghounim Ramadan Mohamed,Hazem Sayed Ahmed Ayoub,Al-Sayed M Rashed,Waleed S El-Nasser,Hani Ismail Hamed,Hossam Aladl Aladl,Mostafa Sabrh,Ahmed Eliwa,Esam M Ghamry,Rady Elmonier,Mahmoud Osama Ahmed Abd El Fattah,Saad El Deen Mohamed El Sheref,Tamer M Mahmoud
Erythropoietin (EPO) resistance is frequently reported in hemodialysis (HD) patients. Metabolic syndrome (MetS) is a common biochemical condition that comprises central obesity, dyslipidemia, hypertension, and hyperglycemia. The present study aimed to assess the relation between MetS and EPO resistance in HD patients. The present multicentric study included 150 patients with EPO resistance and 150
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Short- and long-term outcomes of patients with hyper or hypothyroidism following COVID vaccine. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-18 Efrat Markus,Anat Bel-Ange,Carlos Benbassat,Miriam Steinschneider,Ronit Koren
Since the beginning of the wide-scale anti-Coronavirus disease 2019 (COVID-19) vaccination program, sporadic cases of thyroid disease following vaccination have been reported. We describe 19 consecutive cases of COVID vaccine-related thyroid disease. Medical records were reviewed for 9 patients with Graves' disease (GD) and 10 with Thyroiditis, all of whom were diagnosed following COVID-19 vaccination
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Prevalence of active and passive smoking among asthma and asthma-associated emergency admissions: a nationwide prevalence survey study. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-18 Irina Balan,Syed Nazeer Mahmood,Richa Jaiswal,Yelena Pleshkova,Divya Manivannan,Shayaan Negit,Viraj Shah,Prarthana Desai,Narayana Varalakshmi Akula,Muhammad Umair Nawaz,Namratha Gurram,Raghavendra Tirupathi,Urvish Patel,Vikramaditya Samala Venkata
Asthma affects 7% of children and 8% of adults in the United States. There is a paucity of studies examining the association between passive smoking and an increased risk of asthma exacerbations that led the authors to examine the association between various modes of smoking and rates of asthma exacerbations. A retrospective cross-sectional/case-control study was conducted using the National Health
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Machine learning, a new tool for the detection of immunodeficiency patterns in systemic lupus erythematosus. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-09 Iciar Usategui,Julia Barbado,Ana María Torres,Joaquín Cascón,Jorge Mateo
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects several organs and causes variable clinical symptoms. Early diagnosis is currently the most effective way to save the lives of patients with SLE. But it is very difficult to detect in the early stages of the disease. Because of this, this study proposes a machine learning system to help diagnose patients with SLE. To carry
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A prospective observational multicentric clinical trial to evaluate microscopic examination of acid-fast bacilli in sputum by artificial intelligence-based microscopy system. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-09 Prashant Gupta,Vineeta Khare,Anand Srivastava,Jyotsna Agarwal,Vineeta Mittal,Vijay Sonkar,Shelly Saxena,Ankit Agarwal,Amita Jain
Microscopy-based tuberculosis (TB) diagnosis i.e., Ziehl-Neelsen (ZN) stained smear screening still remains the primary diagnostic method in resource poor and high TB burden countries, however itrequires considerable experience and is bound to human errors. In remote areas, wherever expert microscopist is not available, timely diagnosis at initial level is not possible. Artificial intelligence (AI)-based
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Study of antibiotic resistance and virulence genes in Escherichia coli isolated from urinary tract infection patients in Tanta University Hospitals. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-06 Aya A Helmy,Muhammad T Abdel Ghafar,Hanaa I Okda,Amany M Abo-Elenein
This study aimed to investigate the prevalence of antibiotic resistance genes CTX-M and Qnr, as well as the virulence genes HlyA, Pap, CNF1, and Afa, in uropathogenic Escherichia coli (UPEC) isolates from the Egyptian population. In this cross-sectional study, a total of 50 E. coli isolates were collected from urine samples from patients with urinary tract infections (UTIs) admitted to Tanta University
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The role of ultrasound in determining the presence and severity of carpal tunnel syndrome in diabetic patients. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-06 Yasar Sertbas,Nimet Dortcan,Esin Derin Cicek,Meltem Sertbas,Nalan Okuroglu,Hande Erman,Ali Ozdemir
Carpal tunnel syndrome (CTS) is seen in 5% of the population and 14%-30% in diabetics. Although electrophysiological tests are used as the gold standard method in the diagnosis, alternative methods are being studying. We aimed to investigate whether the measurement of median nerve cross-sectional area (CSA) by ultrasound is associated with the presence and severity of CTS. This prospective, cross-sectional
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Spleen size change after hepatitis C treatment: a simple parameter to predict clinical outcomes. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-05 Shahana Prakash,Kyle Kinder,Kyle E Brown
Portal hypertension contributes to splenomegaly in cirrhotic patients. Reduction in spleen size may represent improvement in portal hypertension. The goal was to determine whether reduction in spleen size following sustained virologic response (SVR) in patients with hepatitis C virus (HCV) cirrhosis is associated with lower risk of liver-related adverse outcomes. A retrospective cohort study was performed
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Metabolomics in acromegaly: a systematic review. J. Investig. Med. (IF 2.6) Pub Date : 2023-05-04 Oana Pînzariu,Carmen Emanuela Georgescu
The therapeutic response heterogeneity in acromegaly persists, despite the medical-surgical advances of recent years. Thus, personalized medicine implementation, which focuses on each patient, is justified. Metabolomics would decipher the molecular mechanisms underlying the therapeutic response heterogeneity. Identification of altered metabolic pathways would open new horizons in the therapeutic management
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Mentor training for junior faculty: a brief evaluation report from the Georgia Clinical and Translational Science Alliance. J. Investig. Med. (IF 2.6) Pub Date : 2023-04-21 Robin E McGee,Henry M Blumberg,Thomas R Ziegler,Ighovwerha Ofotokun,Pamela T Bhatti,Douglas F Paulsen,Alexander Quarshie,Payaningal R Somanath,Dawn L Comeau
To provide a foundation for mentoring, junior faculty participated in a mentor training workshop informed by the Mentoring Clinical and Translational Researchers curriculum. The goal was to develop skills and behaviors that engender more rewarding and inclusive mentoring practices. Attendees responded to baseline and follow-up surveys assessing perceived mentoring skills. Follow-up surveys included
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Butylphthalide protects against ischemia-reperfusion injury in rats via reducing neuron ferroptosis and oxidative stress. J. Investig. Med. (IF 2.6) Pub Date : 2023-04-18 Jun-Dong Lu,Mei-Lin Sun,Pei-Li,Xiao-Peng Wang
Local ischemia in the cerebra leads to vascular injury and necrosis. Ferroptosis is involved in the pathophysiological process of many diseases and widely exists when ischemia-reperfusion injury occurs in many organs. The aim of this study was to evaluate the effect of Butylphthalide (NBP) on middle cerebral artery occlusion (MCAO) rats model-caused neuron injury. Sprague Dawley Rats were randomly
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Development and validation of a scoring system incorporating tumor growth pattern and perineural invasion for risk stratification in colorectal cancer. J. Investig. Med. (IF 2.6) Pub Date : 2023-04-18 Yulin Liu,Yiting Wang,Su Yao,Changhong Liang,Qian Li,Zaiyi Liu,Yaxi Zhu,Yanfen Cui,Ke Zhao
Tumor growth pattern (TGP) and perineural invasion (PNI) at the invasive margin have been recognized as indicators of tumor invasiveness and prognostic events in colorectal cancer (CRC). This study aims to develop a scoring system incorporating TGP and PNI, and further investigate its prognostic significance for CRC risk stratification. A scoring system, termed tumor-invasion score, was established
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E-cigarette use and prevalence of lung diseases among the U.S. population: a NHANES survey. J. Investig. Med. (IF 2.6) Pub Date : 2023-04-13 Sudha Dirisanala,Srishti Laller,Naga Ganti,Shafaq Taj,Neel Patel,Kunwardeep Singh Arora,Inemesit Williams,Ayesha Hameed,Aasa Deepika Kuditipudi,Yadanar Win Lei,Raghavendra Tirupathi,Sachin Gupta,Urvish Patel,Vikramaditya Samala Venkata
The primary aim of this study was to evaluate epidemiological characteristics and prevalence of lung disease among e-cigarettes users in the United States. A population-based, cross-sectional survey was performed using the National Health and Nutrition Examination Survey (NHANES) of 2015-2018. Adults using e-cigarettes (SMQ900), traditional smoking (SMQ020: > 100 cigarettes in lifetime or SMQ040: current
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Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis. J. Investig. Med. (IF 2.6) Pub Date : 2023-03-31 Vikash Jaiswal,Song Peng Ang,Helen Huang,Navroop Kaur Momi,Maha Hameed,Sidra Naz,Nitya Batra,Angela Ishak,Neel Doshi,Asmita Gera,Medha Sharath,Madeeha Subhan Waleed,Nishchita Raj,Victor Hugo Aguilera Alvarez
The association between nonalcoholic fatty liver disease (NAFLD) with cardiovascular and cerebrovascular outcomes, as well as their clinical impact, has yet to be established in the literature. This meta-analysis aims to evaluate the association between the NAFLD patients and the risk of atrial fibrillation (AF), heart failure (HF), stroke, cardiovascular mortality (CVM), and revascularization incidence
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Building a new regional home for implementation science: Annual Midwest Clinical & Translational Research Meetings. J. Investig. Med. (IF 2.6) Pub Date : 2023-03-31 Angelica C Scanzera,Sharmilee M Nyenhuis,Brittany N Rudd,Megha Ramaswamy,Stephanie Mazzucca,Mario Castro,David J Kennedy,Robin J Mermelstein,David A Chambers,Steven M Dudek,Jerry A Krishnan
The vision of the Central Society for Clinical and Translational Research (CSCTR) is to "promote a vibrant, supportive community of multidisciplinary, clinical, and translational medical research to benefit humanity." Together with the Midwestern Section of the American Federation for Medical Research, CSCTR hosts an Annual Midwest Clinical & Translational Research Meeting, a regional multispecialty
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The effect of over- and undertreatment of hypothyroidism on hospitalization outcomes of patients with decompensated heart failure. J. Investig. Med. (IF 2.6) Pub Date : 2023-03-28 Dana Kagansky,Karen Or,Matan Elkan,Shlomit Koren,Ronit Koren
The effect of over- and undertreatment of hypothyroidism on hospitalization outcomes of patients with acute decompensated heart failure (HF) has not been evaluated yet. We conducted retrospective cohort analyses of outcomes among 231 consecutive patients with treated hypothyroidism who were admitted to internal medicine departments of Shamir Medical Center with HF (2011-2019). Patients were divided