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Beginning of the whips: Proposed sequence in the formation of whip‐like heterophil projections Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-03-13 Nicole I. Stacy, John W. Harvey
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
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Metastatic cutaneous myxosarcoma in an adult horse Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-03-03 Andreza A. Rabelo, Renata P. A. Maranhão, Ana Luísa S. de Miranda, Natalia M. Ocarino, Camila I. Amaral, Paulo R. O. Paes, Nathalia C. C. Monteiro, Priscila Fantini
A 25-year-old mixed-breed equine with separate nodular cutaneous lesions in the right thoracic limb (RTL) and right ventral abdominal region was admitted to a Veterinary Hospital in Belo Horizonte, Minas Gerais. Fine-needle aspiration cytology was performed on the RTL lesion and superficial cervical lymph node, and the results were suggestive of a malignant neoplasm known as myxosarcoma. Due to the
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Effects of canine influenza infection and DA2PP vaccination on the development of platelet-associated immunoglobulins and platelet counts in dogs Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-03-03 Maggie Williams, Sarah Shropshire, Nida Chornarm, Melissa Brewer, Jennifer Hawley, Matthew Khorsand, Michael Lappin
Immune thrombocytopenia (ITP) is commonly associated with platelet-associated immunoglobulins (PAIg). Demonstration of PAIg can help determine etiologies for thrombocytopenia. In humans, ITP and thrombocytopenia have been associated with various vaccinations and influenza infections, respectively.
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Immune-mediated hemolytic anemia and pure red cell aplasia in a Jack Russell Terrier during treatment for hypoadrenocorticism Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-03-03 Shunya Yokota, Masashi Yuki
An 11-year-old neutered male Jack Russell Terrier was presented to Yuki Animal Hospital for regenerative anemia during the treatment of hypoadrenocorticism. A blood smear examination showed spherocytes, polychromatic erythrocytes, and erythrocyte ghosts. The direct agglutination test was positive at 37°C. The dog was then diagnosed with immune-mediated hemolytic anemia (IMHA). Although prednisolone
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Gastrointestinal colonization by Diutina (Candida) rugosa in a 6‐year‐old Siberian Husky Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-29 Nina K. Randolph, Jiwoong Her, Camille A. McAloney, Maxey Wellman
A 6‐year‐old 21.5 kg castrated male Siberian Husky was presented for acute onset of lethargy, vomiting, hemorrhagic diarrhea, and inappetence. Physical examination revealed marked discomfort upon abdominal palpation and 5%–7% dehydration. The CBC and biochemical profile revealed changes consistent with mild to moderate inflammation, dehydration, and gastrointestinal (GI) disease. Despite aggressive
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Telangiectatic osteosarcoma in four dogs: Cytologic, histopathologic, cytochemical, and immunohistochemical findings Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-28 Laura A. Cagle, Morgan Maisel, Francisco O. Conrado, Courtney Wait, Katherine Peper, Tannis Lochhead, Thao Vo, Jacqueline K. Dolan, Helena Hauck de Oliveira, Sarah Bosch, Randall Walker, Stacey A. Fox-Alvarez, Erin Porter, Sheila Carrera-Justiz, Christopher J. Lanier, Aline Rodrigues Hoffmann, Michael J. Dark, Leslie C. Sharkey
Telangiectatic osteosarcoma is a rare variant of osteosarcoma histologically and clinically similar to hemangiosarcoma (HSA). This case series describes the imaging and cytologic features of four histologically confirmed telangiectatic osteosarcomas, including the use of cytochemical stains. Alkaline phosphatase (ALP) was applied to Wright–Giemsa-stained cytology slides, and Factor VIII immunohistochemistry
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Clinical, pathologic, and molecular characterization of a non-metastatic multicentric cutaneous mast cell tumor in a cow Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-28 Lucie Chevallier, Amaury Briand, Edouard Reyes-Gomez, Wilfried Defer, Yves Millemann, Jérémy Béguin
Cutaneous mast cell tumors are rarely reported in cattle. Although mutations in the c-KIT gene have been shown to play a central role in the oncogenesis of canine mast cell tumors, few data are available in cattle. This report describes the clinical, histologic, immunohistochemical, and genetic features of a multicentric cutaneous mast cell tumor in an adult cow. An 11-year-old Prim'Holstein cow was
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What is your diagnosis? External bilateral ear cysts in a cat Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-28 Milena Carolina Paz, Igor R. Santos, Fernanda G. Cony, Marcele B. Bandinelli, Alan G. Pöppl, Saulo P. Pavarini
CONFLICT OF INTEREST STATEMENT The authors have no affiliations or financial involvement with any organization or entity with a financial interest in, or in financial competition with, the subject matter or materials discussed in this article.
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What is your diagnosis? Subcutaneous inguinal mass in a dog Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-25 Eryca C. Lamego, Milena C. Paz, Igor R. dos Santos, Stella M. P. de Melo, Edgar C. da Silva, Thatiana S. Assumpção, Geovana K. F. Stumm, Saulo P. Pavarini, Marcele B. Bandinelli
4 DISCLOSURE The authors have no affiliations or financial involvement with any organization or entity with a financial interest in, or in financial competition with, the subject matter or materials discussed in this article.
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A comparison study between the Siemens ADVIA 120 and manual method for the differential white blood cell count in goats Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-23 Ioannis L. Oikonomidis, Christos Brozos, Theodora K. Tsouloufi, Evangelos Kiossis, Maria Kritsepi-Konstantinou
Although widely used, the ADVIA 120 hematology analyzer has not been previously validated for determining the differential leukocyte count in goats.
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What is your diagnosis? Cervical mass in a dog Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-22 Alexandra C. E. Draper, Ioannis Oikonomidis, Alice Pastorello, Roslind McKenzie, Sophie Le Calvez
CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest.
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Comments for the Veterinary Clinical Pathology special issue on laboratory quality management Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-21 Kathleen Freeman
CONFLICT OF INTEREST STATEMENT The author has no conflict of interest.
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Repeat patient testing-quality control compared to commercial quality control material for the Sysmex XT-2000iV hematology analyzer in a multi-site veterinary laboratory Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-14 S. Daly, M. Rishniw, P. A. Graham, K. P. Freeman
Quality control material (QCM) for hematology in veterinary laboratories is limited, and repeat patient testing quality control (RPT-QC) is an alternative method using excess matrix-specific samples.
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Analytical performance of feline plasma on current Heska and IDEXX point-of-care biochemistry analyzers compared with a commercial laboratory analyzer Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-06 Randolph M. Baral, Susan M. Jaensch, Douglas A. Hayward, Kathleen P. Freeman
Point-of-care (POC) biochemistry analyzers are widely used in small animal clinical practice but infrequently independently assessed for performance.
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Serum vitamin D3 (25-OH vit D3) concentrations and hemogram changes in calves with enzootic pneumonia Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-06 Seviye Ertunç, Zafer Mecitoğlu, Sevim Kasap, Sezgin Şentürk
Enzootic pneumonia is an important disease complex associated with insufficient colostrum intake after birth, adverse environmental conditions, and stress. Vitamin D deficiency may be an important predisposing factor for this disease.
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Adipocytes in synovial fluid cytology: An approach for diagnosing synovial lipomatosis Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-06 Beatriz Agulla, Nùria Vizcaíno, Roser Velarde, Josep Estruch, Elisabet Domínguez, Josep Pastor
A 2-year-old neutered male bullmastiff dog was presented with chronic left hind limb lameness. Physical examination revealed left stifle effusion and medial buttress without cranial tibial thrust. Radiographs showed joint effusion and new bone formation at the patella apex. Magnetic resonance imaging showed increased synovial fluid, widening of the joint space, abnormal infrapatellar fat body and thinning
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Development of a reference interval for urinary ammonia-to-creatinine ratio in feline patients Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-06 Eleanor E. Brown, Rebecca A. Castro, Francesca C. Griffin, Wendy W. Mandese, Jenna K. Rooks, Amy E. Stone, Julia A. Wuerz, Kirsten L. Cooke, Andrew J. Specht, Autumn N. Harris
Disruption of acid–base homeostasis can lead to many clinical problems. Ammonia excretion by the kidneys is critical to maintaining acid–base homeostasis through bicarbonate production. Measurement of ammonia excretion may help determine if the kidneys are properly functioning in maintaining acid–base balance. Reference intervals are essential tools for clinical decision-making but do not currently
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Diagnostic utility of the total nucleated cell count for differentiation of septic and sterile peritoneal effusions in dogs Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-06 Amy E. DiDomenico, Megan E. Jacob, Devorah M. Stowe, Erika J. Gruber
Rapid and accurate diagnosis of septic peritonitis is critical for initiating appropriate medical and surgical management.
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What is your diagnosis? Blood smear from a Corolla wild horse stallion Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-02-01 William Benedict, Ashley Parsley, Hiroyuki Mochizuki
CONFLICT OF INTEREST STATEMENT The authors have no affiliations or financial involvement with any organization or entity with a financial interest in, or in financial compensation with, the subject matter or materials discussed in this article.
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Are analytical performance specifications derived from reference intervals of any use in the veterinary clinical laboratory? A preliminary study on the empirical biological variation model Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-18 Simone Manzocchi, Liesl J. van Rooyen
Analytical performance specifications (APS) are vital for method evaluation and quality control validation. However, the limited availability of biological variation (BV) data, regulatory guidelines, and expert opinion (EO) may present challenges in veterinary medicine. The empirical biological variation (EBV) approach, based on population reference intervals (pRI), has emerged as an alternative method
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What is your diagnosis? A blood film and a saliva direct smear from two inland bearded dragons (Pogona vitticeps) Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-18 Carolina Azevedo, Alisa Rassin, Emily E. Brenner, James F. X. Wellehan, Carolyn Cray, Nicole I. Stacy
CONFLICT OF INTEREST STATEMENT The authors have indicated that they have no affiliations or financial involvement with any organization or entity with a financial interest in, or in financial competition with, the subject matter or materials discussed in this article.
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Atypical disseminated histiocytic sarcoma in a 7-month-old dog Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-19 Maria Garcia-Torres, Bárbara Serrano Muñoz, Joaquim Segalés, Clàudia Mallol, Alba Sanz, María C. López, Xavier Roura
A 7-month-old intact female bearded collie dog was admitted after a 2-week history of progressive cough, inappetence, and lethargy, with no response to previous treatment with doxycycline and steroids. Mild attenuation of lung sounds in the right middle hemithorax was the only abnormality detected on physical examination. Abdominal ultrasound and thoracic radiographs were performed and revealed multifocally
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Multiple myeloma in dogs: Use of the cell block technique as a new diagnostic tool Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-19 Pâmela Cristina Lopes Gurgel Valente, Maria Conceição Peleteiro, Maria Joana Dias, Gonçalo Vicente, Constança Pomba, António Duarte, Jorge Correia
The diagnosis of multiple myeloma (MM) in dogs may be challenging and complex. The cell blocks are a diagnostic technique that allows the characterization of neoplastic cells and, therefore, might help in the diagnosis of atypical MM.
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Cytologic features of canine melanotroph and corticotroph pituitary adenomas Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-18 Adriana P. Furtado, Michelle DeCourcey, Margaret A. Miller, Annie V. Chen, Linda G. Martin, Sarah C. Guess, K. Jane Wardrop, Cleverson de Souza, Tina J. Owen
The introduction of intraoperative cytology revolutionized neurosurgical procedures in human medicine, providing real-time diagnostic guidance to surgeons and contributing to improved patient outcomes. In the realm of veterinary medicine, the understanding of pituitary tumors in dogs and cats remains limited due to challenges in obtaining antemortem samples of central nervous system lesions.
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Association of leukergy (in vitro leukocyte aggregation) with systemic inflammation in dogs and cats (2017–2022) Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-18 Rose D. Nolen-Walston, Darko Stefanoski, Francisco O. Conrado
Leukergy is the phenomenon of aggregation of leukocytes on a peripheral blood film, and in humans, it is used as an indicator of systemic inflammation and infection.
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What is your diagnosis? Cranial coelomic mass in a western hognose snake (Heterodon nasicus) Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-02 Alexandria Argue, Shawn Thomas, Sarah Cudd, Laura McCarthy, Elise E. B. LaDouceur
CONFLICT OF INTEREST STATEMENT The authors declare that they have no conflict of interest.
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Osteosarcoma of the wing in a sulfur-crested cockatoo Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-02 Sydney A. Hastain, Lauren Mumm, Sarah Ozawa, Olivia Petritz, Chris Gaudette, Brigid V. Troan, Devorah M. Stowe
A 26-year-old female sulfur-crested cockatoo (Cacatua galerita) was evaluated for vocalizing through the night and extending her right wing. Physical examination revealed a large, firm mass extending from the humerus to the distal aspect of the elbow. Computed tomography confirmed a large aggressive mass of the right distal humerus with a large soft tissue component, severe osteolysis, and adjacent
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What is your diagnosis? Fine needle aspirate from a cutaneous mass in a cat Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-02 Kathryn H. Shaffert, Kayla B. Sample, Jennifer L. Grady, Gisela Martinez-Romero, Francisco O. Conrado
CONFLICT OF INTEREST STATEMENT The authors have no conflict of interest to disclose.
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Performance evaluation of the Sysmex XN-1000V in side-by-side comparison with the Siemens ADVIA 120 and manual methods for healthy CD Sprague–Dawley rats and CD-1 mice Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-02 Jill M. Schroeder, Hsiu-Yung C. Lee, Albert E. Schultze
The Sysmex XN-1000V automated hematology analyzer with multispecies software was released in June 2017 for use in research laboratories. Laser light, impedance, fluorescent staining, and fluorescent flow cytometry are used to analyze whole blood for CBC, reticulocyte counts, and WBC counts, including a 5-part differential leukocyte analysis.
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The importance of quality control validation and relationships with total error quality goals and bias in the interpretation of laboratory results Vet. Clin. Pathol. (IF 1.2) Pub Date : 2024-01-02 Kathleen Freeman, Stefanie Klenner-Gastreich, Jérémie Korchia
The objective of a quality system is to provide accurate and reliable results for clinical decision-making. One part of this is Quality Control (QC) validation. QC validation is not routinely applied in veterinary laboratories. This leads to the inappropriate usage of random QC rules without knowing the Probability of error detection (Ped) and Probability of false rejection (Pfr) of a method. In this
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An IRONic case of PIMA Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-12-28 Megan J. Crawford, Allison R. Rogich, Michael A. Scott, Cynthia A. Lucidi
An 8-year-old spayed female Labrador retriever that was presented for a wellness examination at a referring practice had mild anemia with a hematocrit that progressed from 32% to 25% over the next 5 weeks. The dog's reticulocyte concentration was 26 400/μL on day 23, supporting nonregenerative anemia, and no cause was apparent from clinical and laboratory findings. This prompted the submission of bone
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Hemophilia A in a litter of Border Collies caused by a one base pair deletion in the F8 gene Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-12-17 Maria Brockmann, Niels Mensing, Jennifer von Luckner, Elisabeth Müller, Alexandra Kehl
In dogs, hemophilia A is known to affect different breeds. This is a case report describing hemophilia A in a litter of Border Collies. A privately owned bitch and her puppies (n = 7) were presented to the referring veterinarian after acute hematoma formation in the male offspring (n = 3) following microchip implantation. Global coagulation testing, as well as determination of factor VIII and IX activity
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Silica and barium: Comparison of microscopic appearance and characterization of effects of silica on cytomorphology Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-12-14 Laura A. Cagle, Michael M. Fry, Kenneth B. Wesley, Sarah S. K. Beatty
Silica from plastic red top sample collection tubes and barium cause recognized artifacts in slide preparations for microscopic examination.
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Marked paraneoplastic basophilia in a cat with alimentary T-cell lymphoma Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-12-01 Natalia J. Strandberg, Priscila B. S. Serpa, Lindsey M. Fourez, Michael O. Childress, Christopher M. Fulkerson, Caroline V. Fulkerson, Masahiro Murakami, Andrea P. dos Santos
An 8-year-old, spayed female domestic shorthair cat was presented for acute weight loss, hyporexia, intermittent vomiting, and loose stools. A caudal abdominal mass and thickened intestinal loops were palpated on initial examination. An abdominal ultrasound identified a circumferential intramural jejunal mass with complete loss of wall layering, diffuse thickening of the jejunal muscularis, and jejunal
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B-cell leukemia in an adult sheep Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-27 Adriana P. Furtado, Lindsay M. Fry, Lindsay M. W. Piel, Reginaldo G. Bastos, David A. Schneider, Mara S. Varvil
B-cell leukemia is a rare form of hematologic neoplasia in sheep, especially in adult animals. We present a case report of a 5-year-old WhiteFace Sheep wether with suspected acute lymphoblastic leukemia. The patient, a second-generation relative of ewes experimentally inoculated with atypical scrapie, exhibited acute lethargy and loss of appetite. Laboratory investigation revealed marked leukocytosis
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Creatine kinase and its isoenzymes in the serum and cerebrospinal fluid of healthy canines Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-20 Jennifer H. Kopanke, Annie V. Chen, Jourdan E. Brune, Amanda C. Brenna, Stephanie A. Thomovsky
Creatine kinase (CK) exists as three isoenzymes (CK-MM, CK-MB, and CK-BB) that are predominantly expressed in specific tissues and can be detected in both the serum and cerebrospinal fluid (CSF). CSF CK has been relatively unstudied in veterinary medicine, although studies in human medicine have demonstrated that changes in total CSF CK activity can indicate neurologic abnormalities.
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Repeat patient Testing-Quality control: An example of implementation in a network of commercial laboratories Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-20 Kathleen P. Freeman, Susan Daly, Bente Flatland
The theory and calculations underpinning Repeat Patient Testing-Quality Control (RPT-QC) have been presented in prior publications. This paper gives an example of the process used for implementing RPT-QC in a network of veterinary commercial reference laboratories and the stages associated with the transition to the sole use of RPT-QC. To employ RPT-QC in this commercial laboratory network, eight stages
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What is your diagnosis? Peritoneal fluid from a Hanoverian horse Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-10 Cornelius J. Withers, Luan C. Henker, Kira J. Noordwijk, Claudia Reyner, Maninder Sandey, Emily C. Graff
CONFLICT OF INTEREST STATEMENT The authors have indicated that they have no affiliations or financial involvement with any organization or entity with a financial interest in, or in financial competition with, the subject matter or materials discussed in this article.
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Feline Heinz bodies interfering in standard bicarbonate analysis by the ABL90 FLEX Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-10 Emma Strage, Anna Hillström, Ulrika Falkenö, Anna Sjöström
Venous blood gases were analyzed with ABL90 FLEX in two cats with Heinz bodies in approximately 60% of the erythrocytes. The instrument demonstrated an inability to correctly report standard bicarbonate (stHCO3−), hematocrits, and hemoglobin concentrations by indicating an OXI spectrum mismatch alarm (ie, the spectrum of measured hemoglobin forms differed from the spectrum of calculated forms). Actual
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Antemortem cytologic diagnosis of pulmonary Langerhans cell histiocytosis in a cat Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-01 Alex Mau, Elliott S. Chiu, Anibal Armien, Lynelle R. Johnson, Peter F. Moore, William Vernau
Feline pulmonary Langerhans cell histiocytosis (FPLCH) is a rare histiocytic proliferative disease of middle-aged to older domestic cats. Langerhans cells in the terminal airways proliferate and infiltrate the interstitium and the airways to a lesser degree, widely effacing normal parenchyma. Historically, definitive diagnosis has required postmortem evaluation where pulmonary lesions have a classic
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Serum butyrylcholinesterase activity in healthy dogs with and without exposure to diazinon Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-01 Sara S. F. Almeida, Rayanne H. S. da Silva, Iago M. Oliveira, Luma B. Alonso, Beatriz S. Gonzaga, Alexandre C. M. Barros, Monica C. Vicente, Marília M. Melo, Naida C. Borges, Danieli B. Martins, Ana F. M. Botelho
Cholinesterase is a biomarker for poisonings by anticholinesterase agents, but its reference values are scarce, and possible interaction with collars containing parasiticides has not been studied.
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Spindle-cell thymoma colliding with a bronchogenic cyst in a Yorkshire terrier Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-01 Stephanie Kline, Sabrina R. Manley, Clare Timothy, Samuel H. Jennings, Rose Nolen-Walston, Francisco O. Conrado
An 8-year-old male Yorkshire terrier was presented to the Tufts Veterinary Hospital for evaluation of increased respiratory effort. A mediastinal mass composed of a spindle-cell thymoma within a bronchogenic cyst was diagnosed with computed tomography thoracic imaging, ultrasound-guided fine-needle aspirate biopsy, and histopathologic evaluation after surgical removal. Histologic evaluation showed
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Extracardiac adult-type rhabdomyoma—Report of two cases in dogs Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-11-01 Katarzyna Paździor-Czapula, Muhammad Nasir Bhaya, Agnieszka Piotrowska, Iwona Otrocka-Domagała
This report describes the cytologic, histopathologic, and immunohistochemical features of adult-type rhabdomyoma located within the subcutaneous tissue in a 14-year-old female Border Collie (thigh) and a 13-year-old male Mongrel (flank). In both cases, fine-needle aspiration biopsy revealed cluster-forming, epithelial-like polygonal cells with abundant foamy cytoplasm, and moderate to marked anisocytosis
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Establishing hematologic and biochemical reference intervals for the endangered Lear's macaw (Anodorhynchus leari) Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-10-23 Paula da Costa Machado, Caio Filipe da Motta Lima, Patrícia Locosque Ramos, Carolina Romeiro Fernandes Chagas, Paula Andrea Borges Salgado
The Lear's macaw, Anodorhynchus leari (Psittaciformes, Psittacidae), is an endemic species of the Caatinga region in Brazil. With only a few free-living individuals that are constantly under threat from agricultural clearance, hunting, and trapping, A. leari is classified as “endangered” by the Red Book of Endangered Brazilian Fauna and by the International Union for Conservation of Nature. At the
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Eosinophilic cavitary effusions in cats: 48 cases (2010–2020) Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-10-03 Meagan A. Wheatley, Devorah M. Stowe, Hiroyuki Mochizuki
Eosinophilic effusions are commonly defined as effusions with ≥10% eosinophils. Eosinophilic cavitary effusions are infrequently observed in cats, with few case reports comprising the majority of the recent literature.
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What is your diagnosis? Intraabdominal mass in a dog Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-09-20 Mami Murakami, Keishi Owaki, Minami Goto, Kayoko Yonemaru, Akihiro Hirata, Hiroki Sakai
CONFLICT OF INTEREST STATEMENT The authors have no affiliations or financial involvement with any organization or entity with a financial interest in or in financial competition with the subject matter or materials discussed in this article.
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Comparison of hematologic and serum biochemical variables in Brucella-infected and Brucella-free adult Himalayan marmots (Marmota himalayana) Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-09-18 Nan Wang, Qingfeng Zhu, Shanshan Zhao, Wenbo Tan, Suwen Wang, Songsong Xie, Yuanzhi Wang
The Himalayan marmot (Marmota himalayana) plays a reservoir role in the epidemiology of brucellosis. However, the changes in blood biochemical parameters are still unclear in Brucella-seropositive marmots.
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A retrospective evaluation of phenobarbital-induced hematologic changes in 69 cats Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-09-18 Anna Dohány, Abigail Guija-de-Arespacochaga, Daniela Fux, Christina Silberbauer, Ákos Pákozdy
Phenobarbital (PB) is used as a first-line treatment for recurrent epileptic seizures in cats. While hematologic abnormalities are well-known side effects of antiepileptic therapy with PB in humans and dogs, little is known about such alterations in cats.
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Cytologic, histopathologic, and immunohistochemical features of keloidal fibroma in a dog Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-09-03 Jelena Palić, Veronique Saey, Jaco van der Lugt, Wolfgang Baumgärtner, Kirsten Hülskötter
A five-year-old male English Bulldog was presented with a firm, well-circumscribed, 1 cm in diameter cutaneous mass on the left flank. Fine-needle aspiration (FNA) biopsy samples were collected for cytologic analysis. Cytology revealed a highly cellular sample consisting of spindle cells, numerous bundles of thick, glassy eosinophilic material (hyalinized collagen), and inflammatory cells. Spindle
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What's the matter with this foreign matter? Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-09-01 Francisco O Conrado,Nicole I Stacy
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Regenerative response in dogs naturally and experimentally infected with Babesia rossi Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-08-28 Chandini Seejarim, Yolandi Rautenbach, Emma H. Hooijberg, Andrew L. Leisewitz, Johan P. Schoeman, Amelia Goddard
The regenerative response following Babesia rossi infection in dogs is mild, despite severe hemolytic anemia.
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What is your diagnosis? Postmortem impression smear from a kitten with lung nodules Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-08-24 Cierra B. Starbird, Rachel L. A. L. T. Neto, Cornelius J. Withers, Emily C. Graff, Lindsay A. Starkey, Maureen A. McMichael, Aina Claret
CONFLICT OF INTEREST STATEMENT The authors have no conflict of interest to disclose.
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What is your diagnosis? Additional cluster on the white blood cell differential scattergram using the Sysmex XN-V hematology analyzer in the blood of a dog Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-08-23 Theo Chenal, Maud Guerlin, Maxime Jurrus, Rachel Tanté, Fanny Granat, Catherine Trumel
CONFLICT OF INTEREST STATEMENT The authors have no conflict of interest to disclose.
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A review of Bland–Altman difference plot analysis in the veterinary clinical pathology laboratory Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-08-24 A Russell Moore
Current guidelines recommend using Bland–Altman plots (BA-plots), also called Difference plots, as part of method comparison evaluation in the veterinary clinical pathology laboratory. Analysis of differences can meaningfully augment linear regression techniques and allows fuller summarization of the performance of two methods relative to each other. This work summarizes the current literature on BA-plot
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Reliability of the Enterprise Point-of-Care (EPOC) blood analyzer's calculated arterial oxygen-hemoglobin saturation in immobilized white rhinoceroses (Ceratotherium simum) Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-08-23 Thembeka K. Mtetwa, Edward P. Snelling, Ashleigh C. Donaldson, Peter E. Buss, Leith C. R. Meyer
Enterprise Point-of-Care (EPOC) blood analysis is used routinely in wildlife veterinary practice to monitor blood oxygenation, but the reliability of the EPOC calculated arterial oxygen-hemoglobin saturation (cSaO2) has never been validated in the white rhinoceros (Ceratotherium simum), despite their susceptibility to hypoxemia during chemical immobilization.
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Melanophoroma in a Lichtenstein's green racer snake Vet. Clin. Pathol. (IF 1.2) Pub Date : 2023-08-16 Alan S. Beanes, Marina C. dos Passos, Eduarda A. N. L. D. Cavalcanti, Gabriel da S. Zani, Marcele B. Bandinelli, Paulo da M. Bandarra, Cristina G. Fernandes, Raqueli T. França
Melanophoroma is a neoplasm of reptilian pigment cells, considered uncommon and part of a group of neoplasms called chromatophoromas. The objective of this work was to describe a case of melanophoroma in a free-living Lichtenstein's green racer snake (Philodryas olfersii), presenting with an ulcerative nodular neoformation in the integument of the head region. In the neurologic evaluation, a proprioceptive