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From the archives of MD Anderson Cancer Center: Monomorphic epitheliotropic intestinal T-cell lymphoma: A case with an unusual immunophenotype and discussion of differential diagnosis Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-03-08 Nicholas J. Dcunha, Qing Wei, Beenu Thakral, L. Jeffrey Medeiros
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and aggressive T-cell neoplasm associated with poor survival. We report a case of MEITL that presented as an ulcerated mass in the jejunum with perforation. Microscopic examination showed that the neoplasm involved the full thickness of the intestinal wall, extended into the mesentery, and was composed of monomorphic, small to
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Analysis of glomerular deposition of IgM and C3 in patients with podocytopathies Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-03-07 Verônica Aparecida Ferreira, Crislaine Aparecida da Silva, José Rodrigues do Carmo Neto, Laura Penna Rocha, Ana Luisa Monteiro dos Santos Martins, Marlene Antônia dos Reis, Juliana Reis Machado
Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS) are the main causes of nephrotic syndrome in the world. The complement system appears to play an important role in the pathogenesis of these diseases. To evaluate the deposition of immunoglobulins and particles of the complement system in renal biopsies of patients with FSGS and MCD and relate to laboratory data, we selected
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Interpreting HER2-low at the lower end: Added challenge to the pathologists Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-03-07 Thaer Khoury
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Comparison of TERT and 5-hydroxymethylcytocine immunohistochemistry in various thyroid carcinomas Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-03-06 Hyeong Rok An, Won Gu Kim, Yu-Mi Lee, Tae-Yon Sung, Dong Eun Song
Telomerase reverse transcriptase () promoter mutation is associated with an aggressive clinical course in thyroid carcinomas. Therefore, detection of promoter mutation is essential for proper patient management. 5-Hydroxymethylcytosine (5hmC) is an epigenetic marker involved in the DNA demethylation pathway, and its loss has been observed in various tumors. Loss of 5hmC has also been reported in thyroid
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Concomitant expression patterns of CDX2 and SATB2 as prognostic factors in stage III colorectal cancers Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-03-06 Ji-Ae Lee, Hye Eun Park, Hye-Yeong Jin, Lingyan Jin, Nam-Yun Cho, Jeong Mo Bae, Jung Ho Kim, Gyeong Hoon Kang
CDX2 and SATB2 are often used as biomarkers for identification of colorectal origin in primary or metastatic adenocarcinomas. Loss of CDX2 or SATB2 expression has been associated with poor prognosis in patients with colorectal cancer (CRC). However, little is known regarding clinicopathological features, including prognosis, of CRCs with concomitant loss of CDX2 and SATB2.
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Concordance between pathologists and between specimen types in detection of HER2-low breast carcinoma by immunohistochemistry Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-03-02 Jing Wang, Esther Yoon, Savitri Krishnamurthy
Recent clinical trials indicate that HER2-targeted therapy may benefit HER2-low breast cancer patients including HER2 score 1+ or 2+ and no gene amplification. 57 patients with HER2 negative breast cancer (IHC 0, 1+, or 2+, no gene amplification) by core biopsy were included. Core biopsy and representative tumor from corresponding surgical excision was immunostained for HER2. Original HER2 IHC scores
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Expression of CD25, mast cell markers and T-cell markers in eosinophilic esophagitis Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-03-01 Arkar Htoo, Cary M. Qualia, Rose George, Soe Htet Arker, Nusret Bekir Subasi, Hwajeong Lee, Lorene Chung, Anne Chen
While eosinophilic esophagitis (EOE) is defined by histologic presence of eosinophils, a few studies have established the presence of mast cells in EOE and even shown their correlation with symptom persistence despite resolution of eosinophils. Expression of aberrant mast cell markers CD25 and CD2 have not been studied in EOE. This study quantifies the number of hotspot cells per high power field expressing
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Epstein-Barr virus latency patterns in polymorphic lymphoproliferative disorders and lymphomas in immunodeficiency settings: Diagnostic implications Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-02-29 Ashley K. Volaric, Atif Saleem, Sheren F. Younes, Shuchun Zhao, Yasodha Natkunam
Epstein-Barr virus (EBV) is responsible for many B cell lymphoproliferative disorders (LPD) spanning subclinical infection to immunodeficiency-related neoplasms. EBV establishes a latent infection in the host B cell as defined histologically by the expression of EBV latent membrane proteins and nuclear antigens. Herein, we characterize the latency patterns of immunodeficiency-related neoplasms including
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Esophageal adenocarcinoma heterogeneity in clinicopathology and prognosis: A single center longitudinal study of 146 cases over a 20-year period Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-02-27 Qin Huang, Edward Lew, Yuqing Cheng, Shweta Shinagare, Vikram Deshpande, Jason S. Gold, Daniel Wiener, H. Christian Weber
Recent genomic studies suggest that esophageal adenocarcinoma (EAC) is not homogeneous and can be divided into true (tEAC) and probable (pEAC) groups. We compared clinicopathologic and prognostic features between the two groups of EAC. Based on endoscopic, radiologic, surgical, and pathologic reports, tumors with epicenters beyond 2 cm of the gastroesophageal junction (GEJ) were assigned to the tEAC
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SALTT study: A retrospective analysis of 111 SAlivary gland tumors of Lung and Tracheobronchial Tree Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-02-24 Nishtha Batra, Prabhashankar Mishra, Trupti Pai, Sabita Jiwnani, George Karimundackal, Virendra Tiwari, Nilendu Purandare, Amit Janu, Vanita Noronha, Amit Joshi, Kumar Prabhash, Anil Tibdewal, Jai Prakash Agarwal, C.S. Pramesh, Rajiv Kumar Kaushal
Primary pulmonary salivary gland-type tumours (PPSGT) are rare lung neoplasms arising from submucosal seromucinous glands in the central airway. We retrospectively analysed the clinicopathological features of 111 PPSGTs diagnosed at our institute between 2003 and 2021. The mean age at diagnosis was 43.8 years(range 6–78 years) and a male-to-female ratio of 2:1. On imaging, 92 % of cases had centrally
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Histopathologic evaluation of gastric intestinal metaplasia in non-neoplastic biopsy specimens: Accuracy and interobserver reliability among general pathologists and pathology residents Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-02-23 Thiyaphat Laohawetwanit, Natcha Wanpiyarat, Nathawadee Lerttanatum, Sompon Apornvirat, Charinee Kantasiripitak, Nawaluk Atiroj, Adiluck Pisutpunya, Putch Phairintr, Komkrit Suttichan, Natcha Poungmeechai, Treepob Tassanawarawat, Natnalin Chumponpanich, Chetiyaphon Khueankaeo, Phirasit Chaijitrawan, Pornchai Sooksaen, Chatdhee Stithsuksanoh, Warut Thinpanja, Worakit Kaewnopparat
This study aimed to evaluate the accuracy and interobserver reliability of diagnosing and subtyping gastric intestinal metaplasia (IM) among general pathologists and pathology residents at a university hospital in Thailand, focusing on the challenges in the histopathologic evaluation of gastric IM for less experienced practitioners. The study analyzed 44 non-neoplastic gastric biopsies, using a consensus
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Evaluation of the follicular patterned thyroid lesions based on the WHO 2022 criteria with an emphasis on the grey-zone lesions Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-02-14 Sunayana Misra, Shashi Dhawan, Sonia Badwal, Arupparna Sengupta, Aanchal Khosla, Sangeet Kumar Agarwal, Seema Rao
Follicular-patterned thyroid nodules (FPTN) are classified byWHO-2022 into benign, borderline and malignant categories. There are however, grey-zone lesions that pose a diagnostic challenge due to ambiguity in defining criteria and inter-observer variability. WHO-2022 has enumerated specific diagnostic criteria for these lesions. Accurate categorization of morphologically similar TNs is vital to reduce
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Evaluation of C4d expression and staining patterns by immunohistochemistry in renal biopsy samples with focal segmental glomerulosclerosis and minimal change disease Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-02-13 Maryam Abedi, Fatemeh Nili, Farshid Dehkhoda, Alireza Abdollahi, Samaneh Salarvand
C4d is an activation product of lectin pathway of complement. Glomerular deposition of C4d is associated with poor prognosis in different types of immune-related glomerulonephritis. The present study was conducted to investigate expression level of C4d and its staining pattern in renal biopsy of patients with focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) by immunohistochemistry
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Comparison of different criteria for estimating major pathological response in resectable non-small cell lung cancer treated with neoadjuvant chemoimmunotherapy Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-01-30 Wei Sun, Xinying Liu, Chenglong Wang, Yumeng Jiang, Dongmei Lin
Background Major pathological response (MPR) is proposed as a surrogate endpoint for survival in non-small cell lung cancer (NSCLC) after neoadjuvant chemoimmunotherapy. However, the criteria for estimating MPR differ between the recommendations of the International Association for the Study of Lung Cancer (IASLC) and the immune-related pathologic response criterion (irPRC). IASLC's criteria focus
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PD-L1 immunohistochemical expression in bladder urothelial cancer with SP263, SP142 and 22C3 antibodies: A comparative study Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-01-20 Panagiotis Paliogiannis, Renato Lobrano, Michele Angelo Bella, Antonella Fara, Maria Gabriela Uras, Maria Antonia Pinna, Alessandro Tedde, Massimo Madonia, Angelo Zinellu, Antonio Cossu
Programmed death ligand 1 (PD-L1) is currently the only biomarker used for the selection of patients with bladder urothelial cancer for immunotherapy. Several platforms, antibodies and scores are currently available for the evaluation of the expression of PD-L1 in immunohistochemistry (IHC). In this study three different antibodies (SP263, SP142 and 22C3) were compared to establish their performances
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Incidental findings during donor liver assessment: Single center experience Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-01-20 Iván A. González, Omer Saeed, Mohamed Mustafa, Sheila E. Segura, Katrina Collins, Tieying Hou, Hector Mesa, Sun M. Lee, Dongwei Zhang, Jingmei Lin, Oscar W. Cummings
Intraoperative consultation of donor liver is an important part of transplant evaluation and determination of liver eligibility. In this study, we describe incidental pathologic findings discovered during the pretransplant evaluation of liver donors in our Institution from 1/2010 to 12/2022. During this 13-year period 369 intraoperative consultations from 262 liver donors were performed. Of those cases
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Overdiagnosis of diffuse mesothelioma: A reminder that pathologists need to think outside the “immunohistochemistry” diagnostic box Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-01-19 Alberto M. Marchevsky
Abstract not available
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Comparison of liquid-based cytology and cell blocks prepared from cell remnants for diagnosis of cervical pathology Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2024-01-12 Elif Kuzucular, Ferhat Ozden, Bahar Muezzinoglu
Background Cervical cancer is a global public health problem with high mortality. Advances in screening programs for cervical cancer are considered key to eliminate cervical cancer. We aimed to examine the contribution of cell block analysis to the detection of epithelial cell abnormalities in cervical smear samples. Methods A total of 559 patients with suspected cervical pathology were examined, and
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Non-papillary thyroid carcinoma diagnoses in the Bethesda system for reporting thyroid cytopathology categories V and VI: An institutional experience Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-29 Myunghee Kang, Na Rae Kim, Jae Yeon Seok
Background The non-papillary thyroid carcinoma (PTC) subgroups of The Bethesda system for reporting thyroid cytopathology (TBSRTC) categories V (Suspicious for malignancy) and VI (Malignant) are rare, and specific tumor typing is difficult. We aimed to analyze histologic outcomes and to investigate the points of caution. Methods We reviewed the electronic database and identified 12,215 cases of thyroid
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The spectrum of cytological findings in patients with BCG lymphadenitis: A series of 13 cases Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-28 Viren L. Vaghasiya, Jitendra G. Nasit, Bhoomika Rupavatiya, Divya D. Bambhaniya, Riya Kaka
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EphB3 protein is a potential ancillary diagnostic biomarker for thyroid cancers Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-25 Xinyue Gao, Rusong Zhang, Yan He, Xuan Wang, Wei Bao, Xiao Feng, Jiaxin Chai, Jiandong Wang
Objective To investigate the expression of ephrin type B receptor 3 (EphB3) in thyroid tumors and its usage as an ancillary diagnostic biomarker for thyroid tumors. Methods Formalin-fixed and paraffin-embedded (FFPE) tissue samples (78 cases) and FNAC samples (57 cases) were assessed with the EphB3 antibody using immunohistochemistry. PTC and other thyroid follicular tumors were compared regarding
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Application of rapid on-site evaluation combined with flexible bronchoscopy in the diagnosis of lung lesions Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-26 Shuang Yan, Lei Pan, Jian Chen, Hua Jiang, Li Gong, Faguang Jin
Background Pathology is considered the gold standard for the diagnosis of lung lesions, but the pathological result is relatively lagging and cannot provide real-time guidance for the biopsy procedure. Objective To investigate the potential application of rapid on-site evaluation (ROSE) during flexible bronchoscopy (FB) in the evaluation and diagnosis of lung lesions. Patients and methods Consecutive
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The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-21 John M. Carney, Victor L. Roggli, Carolyn H. Glass, Sergio Piña-Oviedo, Elizabeth N. Pavlisko
Background The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. Design A database including more than 4000 consultation cases of histologically confirmed mesothelioma was examined to identify cases in which mesothelioma was diagnosed
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Interobserver agreement of pathologic classification and grading of tumoral intraductal pre-invasive neoplasms of the bile duct Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-18 Yasuni Nakanuma, Yasunori Sato, Yuko Kakuda, Yoshiki Naito, Yuki Fukumura, Mana Fukushima, Hiroshi Minato, Shinichi Aishima, Nobuyuki Ohike, Toru Furukawa
Current WHO terminology and recent publications have classified tumoral (grossly visible) intraductal pre-invasive neoplasms of bile duct (TIDN) into three categories: intraductal papillary neoplasm of bile duct (IPNB), intraductal papillary oncocytic neoplasm (IOPN), and intraductal tubulopapillary neoplasm (ITPN). A total of 227 cases of TIDN and related lesions ≥3 mm in height were examined by 10
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Challenges to the effectiveness of next-generation sequencing in formalin-fixed paraffin-embedded tumor samples for non-small cell lung cancer Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-21 Bruno da Silveira Corrêa, Fernanda De-Paris, Guilherme Danielski Viola, Tiago Finger Andreis, Clévia Rosset, Fernanda Sales Luiz Vianna, Luis Fernando da Rosa Rivero, Francine Hehn de Oliveira, Patricia Ashton-Prolla, Gabriel de Souza Macedo
Introduction Next-generation sequencing (NGS) of Formalin-Fixed and Paraffin-Embedded (FFPE) specimens is routine in precision oncology practice. However, results are not always conclusive, and it is important to identify which factors may influence FFPE tumor sequencing success. Materials and methods Here, we evaluated the influence of pre-analytical factors on 705 samples of non-small cell lung cancer
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Clinicopathologic features and diagnostic challenges of small cluster pattern appendiceal neuroendocrine tumors Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-20 Benjamin Gertsen, Juwairiya Arshi, Rena X. Li, Jennifer J. Findeis-Hosey, Aaron R. Huber, Yansheng Hao
Appendiceal neuroendocrine neoplasms (NENs) can present with various growth patterns including the traditional triad of histologic patterns-insular, trabecular and tubular. A small cluster pattern was also found in this study and the literature on this specific morphology is limited. In this study, we conducted a comprehensive review of appendiceal NENs from our institution over a ten-year period.
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Intraoperative pathologic diagnosis of central nervous system lymphomas: A comparison of frozen and permanent section diagnoses, and the significance of preoperative imaging Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-14 Aslı Kahraman, Fikret Dirilenoğlu, İsmail Güzeliş, Kenan Çetinoğlu
Background Central nervous system (CNS) lymphomas, either primary or secondary in origin, are rare malignant tumors affecting the brain, spinal cord, or leptomeninges. Diagnosis of CNS lymphomas is complicated by their diverse clinical presentations, radiological features, and histopathological characteristics. Although frozen section (FS) analysis is commonly employed for various CNS tumors, its role
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Primary gallbladder melanoma: A systematic review of literature Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-13 Shafi Rehman, Pravallika Venna, Sissmol Davis, Ragini Gopagoni, Ritika Uttam, Ameer Mustafa Farrukh, Mahsa Salehi
Primary gallbladder melanoma (PGM) is a rare malignancy with only sporadic cases reported in the English literature. We performed a systematic review of the cases published in the PubMed, Science Direct and Google Scholar databases with the aim of describing the reported clinicopathologic features of PGM. Thirty-six articles reporting on 39 patients were reviewed. There was a male predominance, with
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The liver in fatal COVID-19, the end of an era (or so we hope!) Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-14 Stephen M. Lagana
Abstract not available
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Clinicopathological features of differentiated thyroid carcinoma as predictors of the effects of radioactive iodine therapy Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-12-12 Wen Liu, Beibei Jiang, Jingli Xue, Ruijing Liu, Yuqing Wei, Peifeng Li
Background Patients with differentiated thyroid cancer (DTC) usually have an excellent prognosis; however, 5 %–15 % develop radioactive iodine-refractory (RAIR) DTC (RAIR-DTC), which has a poor prognosis and limited treatment options. The aim of the present study was to investigate the clinicopathological characteristics of RAIR-DTC in order to provide clinical evidence for timely prediction of the
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SMARCB1/INI1-deficient epithelioid and myxoid neoplasms in paratesticular region: Expanding the clinicopathologic and molecular spectrum Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-29 Xiaona Yin, Xiaoqun Yang, Suying Wang, Jue Zhou, Ming Zhao
SMARCB1/INI1-deficient soft tissue tumors with epithelioid and myxoid features are diverse and mainly include soft tissue myoepithelial tumor, extraskeletal myxoid chondrosarcoma, and the recently described myoepithelioma-like tumor of the vulvar region and myxoepithelioid tumor with chordoid features. Because of their overlapping features, the accurate diagnosis and classification of these tumors
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Granulomatous lobular mastitis co-existing with ductal carcinoma in situ: Report of three cases and review of the literature Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-24 Jianmin Zhu, Xiuming Miao, Xin Li, Yang Zhang, Yuan Lou, Hanhan Chen, Xiaofei Liu
Granulomatous lobular mastitis (GLM) is a benign and infrequent chronic breast ailment. Although this lesion can be clinically and radiographically mistaken for early-onset breast cancer, it is a rare occurrence for the two to coexist. This report describes three such cases. In all three patients, the primary signs and symptoms were related to the formation of diffuse breast masses or abscesses. Breast
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Prognostic implications of synaptophysin, CD56, thyroid transcription factor-1, and Ki-67 in pulmonary high-grade neuroendocrine carcinomas Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-22 Yulong He, Lei Zhao, Xiaorong Tang, Qinling Jiang, Xianling Zhao, Yilin Cao
Background The correlation between the expression of immunohistochemical markers and the clinicopathological characteristics of pulmonary high-grade neuroendocrine carcinomas (HGNEC) and its impact on the clinical outcomes of individuals with HGNEC has not yet been explored. Methods This study enrolled patients diagnosed with HGNEC between April 2015 and July 2023. Based on the expression levels of
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A case-control autopsy series of liver pathology associated with novel coronavirus disease (COVID-19) Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-20 Fabiola A. Righi, Richard S. Vander Heide, Rondell P. Graham, Marie Christine Aubry, Jorge A. Trejo-Lopez, Melanie C. Bois, Anja C. Roden, Ross Reichard, Joseph J. Maleszewski, Mariam P. Alexander, Reade A. Quinton, Sarah M. Jenkins, Christopher P. Hartley, Catherine E. Hagen
Background Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) is most well-known for causing pulmonary injury, a significant proportion of patients experience hepatic dysfunction. The mechanism by which SARS-CoV2 causes liver injury is not fully understood. The goal of this study was to describe the hepatic pathology in a large
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Comparative expression of trophoblast cell-surface antigen 2 (TROP2) in the different molecular subtypes of invasive breast carcinoma: An immunohistochemical study of 94 therapy-naive primary breast tumors Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-11 Richard B. Mertens, Elias P. Makhoul, Xiaomo Li, Farnaz Dadmanesh
Background Sacituzumab govitecan, targeting trophoblast cell-surface antigen 2 (TROP2), is approved for the treatment of triple-negative and hormone receptor-positive/HER2-negative breast cancers. However, detailed studies comparing TROP2 protein expression in the different molecular subtypes of breast cancer are limited, and definitive evidence supporting the use of TROP2 as a biomarker for predicting
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Response to letter to the editor Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-31 Padmajaa Krishnan, Thayalan Dineshkumar, Bose Divya, Rajkumar Krishnan, Annasamy Rameshkumar
Abstract not available
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Morphological characteristics of SETD2-mutated locally advanced clear cell renal cell carcinoma: Comparison with BAP1-mutated clear cell renal cell carcinoma Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-04 Kotaro Takeda, Sheldon Bastacky, Rajiv Dhir, Maedeh Mohebnasab, Gabriela M. Quiroga-Garza
SET-domain containing 2 (SETD2) and BRCA1-associated protein 1 (BAP1), both chromatin remodeling genes, are frequently mutated in clear cell renal cell carcinoma (ccRCC) and involved in tumor progression and metastasis. Herein, we studied clinicopathologic features of 7 cases of locally advanced ccRCC with single SETD2 mutation, and compared to 7 cases of locally advanced ccRCC with single BAP1 mutation
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Morphology of immune-mediated hepatitis: A comparison between immune checkpoint inhibitor therapy and combined immune checkpoint inhibitor/anti-angiogenic therapy Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-03 Qiongyan Zhang, Lingli Chen, Xinxin Guo, Licheng Shen, Yufeng Huang, Yi Chen, Ningping Zhang, Ningling Ge, Hong Gao, Wen Zhang, Yingyong Hou, Yuan Ji
Background The combination of immune checkpoint inhibitors (ICIs) with anti-angiogenic drugs has shown promising anticancer effects. However, ICIs can trigger immune-mediated hepatitis (IMH). We aimed to clarify whether the combined use of anti-angiogenic drugs and ICIs would increase the severity of IMH. Methods One hundred IMH patients (ICI monotherapy vs. ICI plus anti-angiogenic therapy 30 vs.
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Focal cortical dysplasia is a frequent coexistent pathology in patients with Rasmussen's encephalitis Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-11-03 Georgi Galev, Richard A. Prayson
Introduction Rasmussen's encephalitis (RE) is a rare, predominantly pediatric epilepsy disorder of unknown etiology. It classically affects one of the cerebral hemispheres and histologically shows cortical chronic inflammation, gliosis, and neuronal loss. The etiopathogenesis of RE remains unknown, with genetic, infectious, and autoimmune factors all speculated to play a role. Although the histologic
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Intrathyroid thymic carcinoma: A clinicopathological analysis of 22 cases Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-28 Yanan Gao, Yi Pan, Ye Luo, Runfen Cheng, Qiongli Zhai
Objective Intrathyroid thymic carcinoma (ITTC) is a rare malignancy. The current understanding of ITTC is inadequate, and there is no standard treatment for ITTC. In the present study, we aimed to explore the clinicopathological characteristics of ITTC and identify potential therapeutic targets. Methods The clinicopathological characteristics of 22 ITTC patients at our institution were reviewed. The
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Utility of MUC4 in the diagnosis of secretory carcinoma of salivary glands Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-28 Saira Fatima, Arsalan Ahmed, Sehar Suleman, Nasir Ud Din
Salivary gland tumors are diverse in morphology and both benign and malignant tumors may pose diagnostic challenges especially in small biopsies. Secretory carcinoma (SC) is histologically characterized by microcysts, follicles, solid growth pattern and occasional papillary structures, and absence of zymogen granules. SC is molecularly defined by the presence of novel gene fusion ETV6::NTRK3. Among
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Reporting the neglected cases of temporomandibular joint ganglion cysts in the systematic review Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-20 Yasir Rehman Khattak, Iftikhar Ahmad
Abstract not available
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The prevalence and clinical significance of HER2 expression in prostate adenocarcinoma Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-20 Fayez Estephan, Coen J. Lap, Jeff Banagan, Martha Antonio, Shanshan Liu, Guoqing Diao, Alexandra Zara Rozalen, Rithika Rajendran, Steven Krasnow, Ramesh Subrahmanyam, Victor E. Nava, Maneesh Jain
Aims Abnormalities in HER2 are well-established oncogenic drivers and are approved therapeutic targets in various malignancies. Prior studies evaluating HER2 expression in prostate cancer (PCa) have yielded variable results. Most of these studies used immunohistochemistry scoring systems based on breast cancer data. The goal of this study was to determine the prevalence and clinical significance of
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Prognostic value of CD44 expression in oral squamous cell carcinoma: A meta-analysis Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-18 Majid Mirhashemi, Masoumeh Sadeghi, Narges Ghazi, Nasrollah Saghravanian, Mohsen Dehghani, Amin Aminian
CD44 as a marker of cancer stem cells (CSCs) may be correlated with tumor growth, cell migration, metastasis and chemo-radiotherapy resistance of cancers. However, the prognostic value of CD44 in oral squamous cell carcinoma(OSCC) remains controversial. Therefore, the purpose of the current study was to evaluate the correlation of CD44 expression with the prognosis of OSCC through a meta-analysis.
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Xanthogranulomatous inflammation of the female genital tract: An 11-year single institutional study of 40 cases Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-14 Parul Mehrotra, Gayatri Ravikumar
Background and objectives Xanthogranulomatous inflammation (XGI) is a rare form of chronic inflammation that affects the female genital tract (FGT). The absence of a standard lexicon in the literature has contributed to the relative obscurity of this condition. We attempt to study this lesion with its various clinicopathological associations. Methodology We conducted an 11-year retrospective study
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Most Siewert type II esophagogastric junction adenocarcinomas in Chinese patients lack a Barrett esophagus background Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-14 Wei-Wei Tan, Chun-Sheng Cheng, Kai-Xin Wang, Mu-Xian Lin, Shao-Xiong Liu, Ling-Ling Kang, Hou-De Zhang
The histological origins and classification of Siewert II esophageal gastric junction (EGJ) adenocarcinomas are controversial. While the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system suggests that they be classified as esophageal cancer, some scholars insist that these cancers include a Barrett esophageal (BE) adenocarcinoma form and a gastric
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Spitz tumor with RAF1 fusion: A report of 3 cases Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-10-05 Michele Donati, Daniel Nosek, Shantel Olivares, Julie Lemahieu, Siebe Loontiens, Boulos Mansour, Pedram Gerami, Dmitry V. Kazakov
Spitz tumors are melanocytic neoplasms morphologically characterized by spindled and/or epithelioid cells and specific stromal and epidermal changes associated with mutually exclusive fusion kinases involving ALK, ROS1, NTRK1, NTRK2, NTRK3, MET and RET, BRAF and MAP3K8 genes or, less commonly, HRAS mutation. RAF1 fusions have been recently detected in cutaneous melanocytic neoplasms, including conventional
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Immunohistochemistry and immunofluorescence utilization audit by subspecialty in an academic setting: A step toward stewardship Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-09-28 Mahmoud A. Khalifa, Brooke Gagner, Liam Chen, Paari Murugan, Molly E. Klein, Emilian Racila, Khalid Amin, Daniel Miller, Jimmie Stewart, Yanli Ding, Mariya Farooqui, Sandhyarani Dasaraju, Oyedele A. Adeyi
There are immunohistochemistry (IHC) and immunofluorescence (IF) panels described in the literature and established by personal and institutional experiences that are in common use by pathologists in their daily practice. Stewardship is a difficult discussion because IHC utilization is influenced by many factors including the pathologist's experience, background, practice setting, personal bias, and
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Ganglion cyst of temporomandibular joint – A systematic review Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-09-20 Padmajaa Krishnan, Thayalan Dineshkumar, Bose Divya, Rajkumar Krishnan, Annasamy Rameshkumar
Ganglion cyst of the temporomandibular joint (TMJ) is an uncommon pathology with uncertain etiology. There is no consensus on their management. The current systematic review aimed to discuss the clinical and histopathological features of ganglion cysts of TMJ, to aid in appropriate treatment. A literature search was done and a total of 20 cases were retrieved from published databases such as PubMed
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Carbon footprint evaluation of routine anatomic pathology practices using eco-audit: Current status and mitigation strategies Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-09-16 Alexis Trecourt, Pierre-Jean Cottinet, Marie Donzel, Marion Favretto, Béatrice Bancel, Myriam Decaussin-Petrucci, Alexandra Traverse-Glehen, Mojgan Devouassoux-Shisheboran, David Meyronet, Geneviève Belleannée, Anne Rullier, Minh-Quyen Lê, Guilhem Rival, Daniel Grinberg, Cyprien Tilmant, Lucie Gaillot-Durand,
Because of global warming, integrating an ecological dimension to the practice of pathology is crucial, as already performed in other medical specialties. The aim of the study was to estimate the greenhouse gas emissions (GHE) of one biopsy/surgical specimen hematoxylin-phloxine-saffron (HPS) slide, one frozen section examination, and one immunohistochemistry (IHC) slide, and to propose environmentally
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Diagnostic utility of combining PRAME and HMB-45 stains in primary melanocytic tumors Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-09-13 Dusan Rasic, Niels Korsgaard, Niels Marcussen, Eva Magrethe Precht Jensen
Background Pathologists face ongoing challenges distinguishing between benign and malignant melanocytic tumors. PRAME (PReferentially expressed Antigen in Melanoma) has a demonstrated value distinguishing between these types of lesions. However, the sensitivity of single immunohistochemistry is variable. HMB-45 is another valuable marker, but on its own, has a limited ability in setting of primary
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Morphological, immunohistochemical, and genetic analyses of epithelioid gastrointestinal stromal tumors Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-09-07 Jingli Shi, Kunkun Sun, Fangzhou Kong, Danhua Shen
Epithelioid gastrointestinal stromal tumors (GISTs) are rare and may be confused with other tumors with epithelioid morphology. Therefore, herein, we collected 12 epithelioid GIST samples and summarized their morphological and immunohistochemical characteristics. Through genetic testing, we explored the correlation between morphology and gene mutations. The results showed that eight tumors showed focal
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Prognostic role of the number of resected and negative lymph nodes in Spanish patients with gastric cancer Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-09-08 Cristina Díaz del Arco, Luis Ortega Medina, Lourdes Estrada Muñoz, Elena Molina Roldán, Soledad García Gómez de las Heras, M. Jesús Fernández Aceñero
Introduction Lymph node (LN) involvement is one of the most critical prognostic factors in resected gastric cancer (GC). Some analyses, mainly conducted in Asian populations, have found that patients with a higher number of total lymph nodes (NTLN) and/or negative lymph nodes (NNLN) have a better prognosis, although other authors have failed to confirm these results. Materials and methods Retrospective
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The topographical distribution of lymph node metastases in colon cancer resections Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-08-23 Kamilla Maria Bech Johannesen, Anne-Marie Kanstrup Fiehn, Susanne Eiholm
In accordance with international guidelines all lymph nodes in colon cancer specimens must be examined to obtain accurate staging. This study aimed to determine the topographical location of lymph node metastases and evaluate if a more limited sampling approach could be an alternative. Partial colectomies received at the Department of Pathology, Zealand University Hospital during a six-month period
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Clinicopathological features of primary malignant perivascular epithelioid cell tumors of ureter: Histologic-radiologic correlation Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-08-23 Runlin Feng, Yanping Tao, Tao Zhang, Shenzhao Zhao, Zhiyuan Yin, Changxing Ke, Jiaping Wang
Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor that is mainly seen in middle-aged women. PEComa originating in the ureter is extremely rare it is unclear whether they display typical clinical and radiographic features seen elsewhere. Herein, we report findings from 2 cases of primary PEComa of the ureter that we classified as malignant. Case 1: A 45-year-old woman was admitted
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Primary plasmablastic lymphoma of the gastrointestinal tract: A series of 13 HIV-negative cases and a review of literature Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-08-19 Zhiyan Fu, Haibo Wang, Gregory Y. Lauwers, Kun Jiang, Nushani L. Jayaratne, Sanjay Bridglal, Ning Dong, Endi Wang, Lugen Chen, Deniz Peker Barclift, Ling Zhang
Context Primary gastrointestinal plasmablastic lymphoma (GI-PBL) is a rare variant of diffuse B-cell lymphoma with an aggressive clinical course. PBL was initially reported among HIV-positive patients; however, subsequent studies have shown that it also occurs among HIV-negative patients. Its clinical characteristics remain poorly understood. This study aims to retrospectively analyze the clinicopathological
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High XB130 expression in renal cell carcinoma is strongly associated with poor prognosis Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-08-19 Piti Ungarreevittaya, Orapin Nintra, Wichien Sirithanaphol, Jarin Chindaprasirt, Sakkarn Sangkhamanon
The aim of this study was to assess the prognostic value of XB130 expression in three major RCC subtypes, and its association with clinical outcomes and adverse clinicopathologic features. A total of 101 nephrectomy samples at Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand, from 2007 to 2017 were included in the study. XB130 immunohistochemistry was performed on slides from
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Epithelioid dedifferentiated liposarcoma: A clinicopathological and molecular study of 6 cases Ann. Diagn. Pathol. (IF 2.0) Pub Date : 2023-08-18 Yuan Tu, Peipei Zhu, I. Weng Lao, Lin Yu, Jian Wang
In this study, we present six cases of epithelioid dedifferentiated liposarcoma to further characterize its clinical and pathological features. The patients are all adult men with age at presentation ranging from 46 to 64 years (median 58.5 years). The patients presented with nonspecific symptoms of retroperitoneal mass, intermittent dull pain or discomfort. None of the patients had any prior history