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Diagnostic immunocytostaining with Peroxisome Proliferator-Activated Receptor-Gamma in urine cytology samples. Acta Cytol. (IF 1.8) Pub Date : 2023-11-26 Shinichi Tanaka,Yasunori Tokuhara,Sanae Ariyasu,Tatsuya Morinishi,Tamami Yamamoto,Norihiro Teramoto,Eiichiro Hirakawa
INTRODUCTION Urine cytology is a common method for detection of urothelial carcinoma (UC), however, is not high sensitivity. Improvement of the accuracy of cytodiagnosis using immunocytostaining as an auxiliary method is needed. This study aimed to determine the cyto-diagnostic usefulness of peroxisome proliferator-activated receptor-gamma (PPAR-γ) immunocytostaining in urine cytology for the detection
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The Kymi Odyssey Honorary Ceremony and the future G.N. Papanicolaou Museum - A personal appeal for support, enrichment, and visitation. Acta Cytol. (IF 1.8) Pub Date : 2023-11-21 Nikolaos Chantziantoniou
This Meeting Report describes the events prior to and following the Kymi Odyssey Honorary Ceremony conducted in Kymi, Greece, on September 15, 2023.
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Impact of the 3rd edition of The Bethesda System for Reporting Thyroid Cytopathology on Grey Zone Categories. Acta Cytol. (IF 1.8) Pub Date : 2023-10-28 Sofia Cuco Guerreiro,Ebru Tastekin,Mariana Mourao,Isabel Loureiro,Rosario Eusebio,Hugo Pinto Marques,Meltem Oznur,Can Kosti Caliskan,Fernando C Schmitt,Massimo Bongiovanni,Sule Canberk
INTRODUCTION Thyroid Bethesda Reporting System is a six-tiered system that aims to bring uniformity in reporting thyroid cytology and improve the communication with clinicians. The system has achieved its goal as a presurgical diagnostic method; however, it remains a screening method in the grey zone categories, namely atypia of undetermined significance (AUS) and follicular neoplasm (FN). The book
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Diagnostic performance of bile duct brush cytology with risk of malignancy of standardized categories in the wake of World Health Organization Reporting System for Pancreaticobiliary Cytopathology: An updated systematic review and meta-analysis. Acta Cytol. (IF 1.8) Pub Date : 2023-10-25 Ashutosh Rath,Immanuel Pradeep,Jitendra Singh Nigam
INTRODUCTION The WHO Reporting System for Pancreaticobiliary Cytopathology revised the Papanicolaou Society of Cytopathology guidelines in alignment with the WHO classification of digestive system tumors, 5th edition. The current systematic review and meta-analysis have been conducted to accurately assess the performance of bile duct brush cytology and report the risk of malignancy (ROM) of each standard
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Accuracy and reproducibility of cytology triage in a HPV-based primary screening setting: a revision of 384 Pap tests. Acta Cytol. (IF 1.8) Pub Date : 2023-09-26 Stefania Cannistrà,Francesca Carozzi,Chiara Di Stefano,Marzia Matucci,Giampaolo Pompeo,Giuseppe Gorini,Donella Puliti,Marco Zappa,Cristina Sani,Massimo Confortini
Introduction After the transition toward the HPV-based screening protocol, which has led to an increase in sensitivity, and in order to bring back the specificity to acceptable values, cytology underwent a change of approach becoming a triage test. For these reasons, in the Tuscany region (after the recommendations of the GISCi document), it was decided to reduce, as much as possible, the use of ASC-US
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A retrospective analysis of the clinicopathological features of patients with tuberculous mastitis: A single institution's experience. Acta Cytol. (IF 1.8) Pub Date : 2023-09-20 Nine-Paula Olmesdahl,Carolina Nel,Aylwyn Mannell,Luvo Fatman
BACKGROUND Tuberculosis remains a global health burden, especially in low- and middle-income countries. Breast tuberculosis is a rare disease with minimal research available. This disease produces a diagnostic challenge as the clinical presentation is variable, and diagnosis often requires additional investigations. This study was undertaken to determine the efficacy of cytology and histology, together
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Deep learning neural network -guided detection of asbestos bodies in bronchoalveolar lavage samples. Acta Cytol. (IF 1.8) Pub Date : 2023-09-19 Antti J Hakkarainen,Reija Randen-Brady,Henrik Wolff,Mikko I Mäyränpää,Antti Sajantila
INTRODUCTION Asbestos is a global occupational health hazard and exposure to it by inhalation predisposes to interstitial as well as malignant pulmonary morbidity. Over time, asbestos fibers embedded in lung tissue can become coated with iron-rich proteins and mucopolysaccharides, after which they are called asbestos bodies and can be detected in light microscopy. Bronchoalveolar lavage, a cytological
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Diagnostic value and challenges of BRAF V600E molecular testing and thyroid FNA cytology: a retrospective study from a tertiary institution in southern Hunan Province, China. Acta Cytol. (IF 1.8) Pub Date : 2023-09-14 Zhihua Lan,Fang Yang,Jing Zhang,Ya Lan,Hongtao Li,Rongfang He
INTRODUCTION Combined thyroid fine-needle aspiration (FNA) cytology and valine-to-glutamate substitution at codon 600 of B-Raf proto-oncogene, serine/threonine kinase (BRAF V600E) mutation detection are procedure used for diagnosing thyroid nodules in many Chinese tertiary institutions. This retrospective study at our institution aimed to explore the effectiveness and challenges of the combined approach
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False-positive atypical endocervical cells in conventional Pap smears: Cyto-histological correlation and analysis. Acta Cytol. (IF 1.8) Pub Date : 2023-08-10 Johanna Pulkkinen,Heini Huhtala,Ivana Kholová
INTRODUCTION Endocervical glandular atypia is relatively rarely diagnosed by Pap smears. A significant proportion of follow-up histological samples show no premalignant or malignant lesions. The observed cytomorphological findings in premalignant glandular lesions overlap with histologically proven reactive lesions. METHODS A total of 45 conventional Pap smears diagnosed as atypical endocervical cells
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Fine-Needle Aspiration of Sarcomas Metastatic to Lymph Nodes: A Cytomorphologic Study over a 10-Year Period. Acta Cytol. (IF 1.8) Pub Date : 2023-07-27 Carla Saoud,Hansen Lam,Syed Z Ali
INTRODUCTION Metastasis of sarcomas to lymph nodes is an uncommon event in its natural history. We aimed to present our experience with fine-needle aspiration (FNA) of metastatic sarcomas to lymph nodes over a 10-year period. MATERIAL AND METHODS The cytopathology archives were searched for FNA of lymph nodes involved by metastatic sarcomas. Available clinicopathologic data were recorded. All slides
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Discriminant Analysis Using Gabor Filter Sets for Lobular Endocervical Glandular Hyperplasia: Numerical Interpretation of Nuclear Atypia by Gabor Filter Features. Acta Cytol. (IF 1.8) Pub Date : 2023-07-27 Fumikazu Kimura,Kengo Ohshima,Keiichiro Shirai,Ryo Kanai,Masaki Sonohara,Keiko Ishii
INTRODUCTION Lobular endocervical glandular hyperplasia (LEGH) is a benign lesion; however, it is considered to be the origin of gastric-type adenocarcinoma in the uterine cervix, and early diagnosis is important. At Shinshu University Hospital, screening of LEGH cells is based on the difference in color tone of cytoplasmic mucin on Papanicolaou staining and detection of gastric mucin using HIK1083-labeled
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Histopathologic Follow-Up of Women with Inadequate ThinPrep™ Cervical Pap Tests and Positive High-Risk Human Papillomavirus Test Results. Acta Cytol. (IF 1.8) Pub Date : 2023-07-26 Gozde Kir,Suleyman Ozen
INTRODUCTION We found only a few studies that had performed high-risk human papillomavirus (hrHPV) analyses of inadequate ThinPrep™ Papanicolaou (Pap) tests. Therefore, this study aimed to analyze unsatisfactory ThinPrep Pap tests using hrHPV tests. The colposcopic biopsy results of cases with an unsatisfactory ThinPrep Pap test and positive hrHPV results were revealed. METHODS Between January 1, 2018
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PD-L1 (22C3) Expression Correlates with Clinical and Molecular Features of Lung Adenocarcinomas in Cytological Samples. Acta Cytol. (IF 1.8) Pub Date : 2023-07-26 Sarah A Anderson,Djamel Harbi,Diana Oramas Mogrovejo,Antoinette D Floyd,Isam-Eldin Eltoum,Huma Fatima,Frida Rosenblum,Manuel Lora Gonzalez,Diana Lin,Alexander C Mackinnon,Gene P Siegal,Thomas Winokur,Ceren Yalniz,Lei Huo,Shuko Harada,Xiao Huang
INTRODUCTION PD-L1 expression is the most widely used predictive marker for immune checkpoint inhibitor (ICI) therapy in patients with lung adenocarcinoma. However, the current understanding of the association between PD-L1 expression and treatment response is suboptimal. A significant percentage of patients have only a cytological specimen available for clinical management. Therefore, it is relevant
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Reliable Cerebrospinal Fluid Cytology and Immunocytochemistry Reporting over an Extended Period by the Addition of Aldehyde and Osmolyte-Based Preservative Solution. Acta Cytol. (IF 1.8) Pub Date : 2023-07-14 Lavleen Singh,Kanika Rastogi,Mamta Jajoo
INTRODUCTION The cytological examination of cerebrospinal fluid (CSF) is an important investigation in the workup of various inflammatory, malignant, or traumatic disorders of the central nervous system. The cells in the CSF lyse and degenerate at a very fast rate owing to its low tonicity, buffering capacity, redox potential, and pH, making it crucial to examine it within 2 h of sampling. We have
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Diagnostic Utility of Claudin4 and Comparison with BerEp4 as a Marker for Metastatic Adenocarcinoma in Serous Effusions. Acta Cytol. (IF 1.8) Pub Date : 2023-06-16 Gunjan Mangla,Pooja Bakshi,Poojan Agarwal,Kusum Verma
INTRODUCTION Fluid cytology for malignant cells is important for diagnosis and staging of malignancies. Morphological overlap between reactive mesothelial cells and adenocarcinoma poses challenges, for which many immunohistochemical markers like BerEp4 and MOC-31 have been used extensively. Claudin4 is a new marker with promising results; however, further studies are required to establish its role
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Correlative Evaluation of Seven Cytological 3-Tier Grading Systems of Breast Carcinoma with the Standard Histological Grading: A 4 and ½ Year Study. Acta Cytol. (IF 1.8) Pub Date : 2023-06-16 Shweta Pai,Srinivasa Murthy V
INTRODUCTION The early diagnosis of breast carcinoma is of paramount importance in its management. Fine-needle aspiration cytology (FNAC) has the potential to play a pivotal role in providing the relevant information on the aggressiveness of this tumor. But there is no gold standard when it comes to cytological grading of breast carcinoma as there is no consensus between the pathologists and also the
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Prolonged Duration of Air-Dry Fixation of Cervical Smears Produces Superior Cytomorphological Staining Quality over Conventional Wet-Fixed Smears. Acta Cytol. (IF 1.8) Pub Date : 2023-05-24 Kwabena Owusu Danquah,Ernest Adankwah,Headtlove E Dadzie,Daniel Gyamfi,Ernest Akwasi Adjei,Paul Poku Ossei Sampene,Emmanuel Morhe
INTRODUCTION Immediate fixation of smears in 95% alcohol for Pap staining is commonly used for cytopathological diagnosis of cancers and other diseases. Few research studies have investigated the comparative outcomes of alcohol wet fixation and rehydration of air-dried smears, indicating that air-dried rehydrated (ARF) smears are viable alternative to wet-fixed (WF) smears. However, there are no or
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Myxoid Soft Tissue Tumors: A 20-Year Experience on Fine Needle Aspiration with Application of the Proposed WHO Reporting System for Soft Tissue Cytopathology. Acta Cytol. (IF 1.8) Pub Date : 2023-05-23 Carla Saoud,Jeffrey Schowinsky,Syed Z Ali
INTRODUCTION Myxoid soft tissue tumors represent a heterogenous group of neoplasms. The study presented our experience on cytopathology of myxoid soft tissue tumors on fine needle aspiration (FNA) and aimed to apply the recently proposed WHO system for reporting soft tissue cytopathology. MATERIAL AND METHODS We performed a 20-year retrospective search of our archives to identify all FNAs performed
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Utility of the Proposed Sydney System for Classification of Fine-Needle Aspiration Cytopathology of Lymph Node: A Retrospective Study at a Tertiary Care Center. Acta Cytol. (IF 1.8) Pub Date : 2023-05-11 Rucha Kanhe,Santosh Tummidi,Kanchan Kothari,Mona Agnihotri
INTRODUCTION Fine-needle aspiration cytology (FNAC) is an established first-line technique for the evaluation of lymphadenopathy and, with the help of ancillary testing, can in many instances obviate the need for an open biopsy. The Sydney system was recently proposed to provide consensus guidelines for the performance, classification, and reporting of lymph node FNAC. The present study was undertaken
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The utility of fallopian tube cytology in the early detection of extrauterine serous gynecological malignancies: a narrative literature review” Acta Cytol. (IF 1.8) Pub Date : 2023-04-12 Victoria Psomiadou, Sofia Lekka, Theodoros Panoskaltsis, Helen Tsouma, Natasa Novkovic, Helen J. Trihia, Olympia Tzaida, Dimitrios Korfias, Panagiotis Giannakas, Christos Iavazzo, Christos Papadimitriou, Nikolaos Vlahos, George Vorgias
Objectives: To analyze the published evidence for the use of fallopian tube brush cytology for the early detection of extrauterine serous gynecological cancer. Methods: We systematically searched the literature and, additionally, cross checked on the bibliographies of selected articles. The inclusion criteria involved studies assessing the utility of fallopian tube brush cytology and its applications
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Cytologic findings in serous effusion specimens from melanoma patients. Acta Cytol. (IF 1.8) Pub Date : 2023-03-30 Paul Shield, Dalisay Liwanag Ribu
Introduction Metastatic melanoma (MM) is an uncommon finding in serous effusion specimens with a highly variable cytomorphology. Methods We reviewed specimens submitted over a 19-year period to determine (a) the range of cytologic findings in effusion specimens from melanoma patients and b) the cytologic presentation and immunoprofile of MM in effusion specimens. Results Of 123 serous effusion specimens
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Comparison of the clinical performance of Aptima HPV assay and the Cobas 4800 platform in women with normal cytology and positive high-risk HPV Acta Cytol. (IF 1.8) Pub Date : 2023-03-28 Gozde Kir, Damla DOKMECI GUNEY, Hatice SENELDİR
Introduction: According to current the American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines, patients with normal cytology results may be referred for colposcopy according to their high-risk human papillomavirus (hrHPV) test results. A higher positive predictive value (PPV) of hrHPV has significance for preventing unnecessary colposcopic examinations. Several studies have compared
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Role of Fine Needle Aspiration Cytology in the Diagnosis of Gynecologic Tumors Acta Cytol. (IF 1.8) Pub Date : 2023-03-14
Background: The tumors involving the gynecologic tract encompass a wide range of lesions including those of epithelial, mesenchymal, sex cord-stromal, and germ cell origin. Amongst the carcinomas of tubo-ovarian origin, high-grade serous carcinoma is the most common malignancy. The primary role of fine needle aspiration (FNA) cytology in the management of gynecologic tract malignancies is in the diagnosis
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The application of the proposed Sydney system for reporting lymph node cytopathology: A five year experience of an academic institution in south India. Acta Cytol. (IF 1.8) Pub Date : 2023-03-14
Introduction: Fine needle aspiration biopsy (FNAB) is a routinely used investigation in the evaluation of lymph node pathologies. However, there exists a lack of uniformity in cytopathology reporting owing to the non-availability of standard guidelines. Recently, a novel system for reporting lymph node cytopathology has been proposed. The present study aimed to analyze the utility of the proposed system
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Role of Fine Needle Aspiration Cytology in the Diagnosis of Gynecologic Tumors Acta Cytol. (IF 1.8) Pub Date : 2023-03-14
Background: The tumors involving the gynecologic tract encompass a wide range of lesions including those of epithelial, mesenchymal, sex cord-stromal, and germ cell origin. Amongst the carcinomas of tubo-ovarian origin, high-grade serous carcinoma is the most common malignancy. The primary role of fine needle aspiration (FNA) cytology in the management of gynecologic tract malignancies is in the diagnosis
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Utility of BAP1, p16 and MTAP immunohistochemistry in cytological and histological samples of pleural mesotheliomas Acta Cytol. (IF 1.8) Pub Date : 2023-03-08 Vera Amacher, Peter Karl Bode, Holger Moch, Daniela Lenggenhager, Bart Vrugt
Introduction: In most cases the diagnostic workup of pleural mesotheliomas (MPM) starts with cytological examination of pleural effusion, but histology is needed to confirm the diagnosis. The introduction of BAP1 and MTAP immunohistochemistry have become a powerful tool to confirm the malignant nature of mesothelial proliferations also in cytological specimens. The objective of this study is to determine
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Utility of BAP1, p16 and MTAP immunohistochemistry in cytological and histological samples of pleural mesotheliomas Acta Cytol. (IF 1.8) Pub Date : 2023-03-08
Introduction: In most cases the diagnostic workup of pleural mesotheliomas (MPM) starts with cytological examination of pleural effusion, but histology is needed to confirm the diagnosis. The introduction of BAP1 and MTAP immunohistochemistry have become a powerful tool to confirm the malignant nature of mesothelial proliferations also in cytological specimens. The objective of this study is to determine
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Kari J. Syrjänen, MD, PhD, FIAC A Tribute to our Editor on His 75th Birthday Acta Cytol. (IF 1.8) Pub Date : 2023-03-03 Ivana Kholová, Fernando Schmitt, Massimo Bongiovanni, Laszlo Vass, Danijela Vrdoljak Mozetic
The Editor-in-Chief of Acta Cytologica, Prof. Kari J. Syrjänen, M.D., Ph.D., FIAC will celebrate his 75th Birthday on March 20, 2023, and we would like to offer a tribute to the 3rd Editor of Acta Cytologica and one of the pioneers in HPV research.
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Kari J. Syrjänen, MD, PhD, FIAC A Tribute to our Editor on His 75th Birthday Acta Cytol. (IF 1.8) Pub Date : 2023-03-03
The Editor-in-Chief of Acta Cytologica, Prof. Kari J. Syrjänen, M.D., Ph.D., FIAC will celebrate his 75th Birthday on March 20, 2023, and we would like to offer a tribute to the 3rd Editor of Acta Cytologica and one of the pioneers in HPV research.
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Adoption of Rapid On-Site Evaluation (ROSE) in the routine evaluation of lung cytology specimens Acta Cytol. (IF 1.8) Pub Date : 2023-03-02 Immanuel Pradeep, Ashutosh Rath, JITENDRA SINGH NIGAM
Not applicable
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Adoption of Rapid On-Site Evaluation (ROSE) in the routine evaluation of lung cytology specimens Acta Cytol. (IF 1.8) Pub Date : 2023-03-02
Not applicable
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Number needed to diagnose in malignant ascites – effects of volume, repeating collection, and primary malignancy on diagnostic performance in peritoneal fluid cytology Acta Cytol. (IF 1.8) Pub Date : 2023-02-23 Joanna K. M. Ng, Lok Hang Chow, Annabelle M. Y. Ngai, Ronald C. K. Chan, Jacqueline H. S. Lee, Alfred L. H. Lee, Joshua J.X. Li, Curtis C. K. To, Gary M. Tse
Introduction Volume recommendations of 80-200ml have been proposed for peritoneal fluid cytology. While cut-offs are impractical when volume is limited by the amount present and disease factors, collections, however, can be repeated. This study addresses adequacy and number needed to diagnose by comparing diagnostic agreement to volumes in single specimens, total volumes collected daily, and within
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Number needed to diagnose in malignant ascites – effects of volume, repeating collection, and primary malignancy on diagnostic performance in peritoneal fluid cytology Acta Cytol. (IF 1.8) Pub Date : 2023-02-23
Introduction Volume recommendations of 80-200ml have been proposed for peritoneal fluid cytology. While cut-offs are impractical when volume is limited by the amount present and disease factors, collections, however, can be repeated. This study addresses adequacy and number needed to diagnose by comparing diagnostic agreement to volumes in single specimens, total volumes collected daily, and within
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To get the most out of the least: BRAF molecular evaluation in melanoma metastases on cell suspension from fine needle aspiration cytology (FNAC) needle rinses. Acta Cytol. (IF 1.8) Pub Date : 2023-02-20 Andrea Ronchi, Marco Montella, Emma Carraturo, Eduardo Clery, Federica Zito Marino, martina amato, giuseppe argenziano, elvira moscarella, gabriella brancaccio, teresa troiani, pasquale alfano, Roberto Alfano, Renato Franco, Immacolata Cozzolino
Abstract Introduction: Cytological samples from cutaneous melanoma (CM) metastases may be the only biomaterial available for diagnostic and predictive purpose in the clinical practice. BRAF evaluation from cytological samples actually implies the loss of one or more diagnostic smears, or the execution of one or more passes to obtain dedicated cytological samples. We tested BRAF molecular evaluation
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To get the most out of the least: BRAF molecular evaluation in melanoma metastases on cell suspension from fine needle aspiration cytology (FNAC) needle rinses. Acta Cytol. (IF 1.8) Pub Date : 2023-02-20
Abstract Introduction: Cytological samples from cutaneous melanoma (CM) metastases may be the only biomaterial available for diagnostic and predictive purpose in the clinical practice. BRAF evaluation from cytological samples actually implies the loss of one or more diagnostic smears, or the execution of one or more passes to obtain dedicated cytological samples. We tested BRAF molecular evaluation
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Clinical impact of fine needle aspiration cytology on sentinel node biopsy after preoperative chemotherapy for core needle biopsy-proven metastatic lymph nodes Acta Cytol. (IF 1.8) Pub Date : 2023-02-16 Rikiya Nakamura, Shouko Hayama, Satoshi Yoshimura, Makiko Itami, Akinobu Araki, Akiko Odaka, Naohito Yamamoto
Introduction: Sentinel node biopsy (SNB) has been increasingly performed for patients with lymph node (LN)-positive (cN1) breast cancer that converted to LN-negative (ycN0) status after neoadjuvant chemotherapy (NAC). This study aimed to clarify the SNB avoidance rates using fine needle aspiration cytology (FNAC) for mLNs after NAC. Methods: This study included 68 patients with cN1 breast cancer undergoing
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Clinical impact of fine needle aspiration cytology on sentinel node biopsy after preoperative chemotherapy for core needle biopsy-proven metastatic lymph nodes Acta Cytol. (IF 1.8) Pub Date : 2023-02-16
Introduction: Sentinel node biopsy (SNB) has been increasingly performed for patients with lymph node (LN)-positive (cN1) breast cancer that converted to LN-negative (ycN0) status after neoadjuvant chemotherapy (NAC). This study aimed to clarify the SNB avoidance rates using fine needle aspiration cytology (FNAC) for mLNs after NAC. Methods: This study included 68 patients with cN1 breast cancer undergoing
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Atypical category of the Johns Hopkins Template has higher ROM than the Paris System but the Paris system is more applicable for suspicious category Acta Cytol. (IF 1.8) Pub Date : 2023-02-02 Betul Celik, Gamze Kavas
Introduction: To compare performance of indivisual categories between the Johns Hopkins template and the Paris system for reporting urinary cytology. Methods: Medical records of patients with bladder biopsy and relevant cytology slides were obtained from archived material. Slides were reclassified according to Johns Hopkins Template and the Paris. Results were compared to histologic diagnoses. Results:
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Atypical Category of the Johns Hopkins Template Has Higher Risk of Malignancy than the Paris System but the Paris System Is More Applicable for Suspicious Category Acta Cytol. (IF 1.8) Pub Date : 2023-02-02
Introduction: The aim of this study was to compare performance of individual categories between the Johns Hopkins template and the Paris system for reporting urinary cytology. Methods: Medical records of patients with bladder biopsy and relevant cytology slides were obtained from archived material. Slides were reclassified according to Johns Hopkins template and the Paris system. Results were compared
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A Practical Approach to Squamous Abnormalities on Cervical Cytology: Overview of Interpretive Criteria and Guidance for Altering Thresholds in Response to Quality Assurance Findings Acta Cytol. (IF 1.8) Pub Date : 2023-01-26 Michael James Thrall
Background: Squamous intraepithelial lesions observed in Papanicolaou (Pap) test gynecologic cytology arise as a result of infection of the cervicovaginal tract by human papillomavirus (HPV). The viral cytopathic effect of HPV manifests as koilocytosis, also known as low-grade squamous intraepithelial lesion (LSIL) in The Bethesda System (TBS). Integration of HPV genetic material into the genome of
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A Practical Approach to Squamous Abnormalities on Cervical Cytology: Overview of Interpretive Criteria and Guidance for Altering Thresholds in Response to Quality Assurance Findings Acta Cytol. (IF 1.8) Pub Date : 2023-01-26
Background: Squamous intraepithelial lesions observed in Papanicolaou (Pap) test gynecologic cytology arise as a result of infection of the cervicovaginal tract by human papillomavirus (HPV). The viral cytopathic effect of HPV manifests as koilocytosis, also known as low-grade squamous intraepithelial lesion (LSIL) in The Bethesda System (TBS). Integration of HPV genetic material into the genome of
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IMPACT OF THE COVID-19 PANDEMIC ON CERVICAL CANCER SCREENING IN SÃO PAULO STATE, BRAZIL Acta Cytol. (IF 1.8) Pub Date : 2023-01-20 Toni Ricardo Martins, Steven S Witkin, Maria Cássia Mendes-Correa, Amanda Scancella de Godoy, Lise Cury, Marcelo Luiz Balancin, Alexandre Muxfeldt Ab'Saber, Stela Verzinhasse Peres, Sandra Messias, Tania Regina Tozetto Mendonza, Adhemar Longatto-Filho
INTRODUCTION: The early identification of precursor lesions followed by appropriate treatment prevents development of cervical cancer and its consequences OBJECTIVE: The present study evaluated the influence of the Covid-19 pandemic on cervical cancer screening by comparing the quantity of tests to detect cervical cellular changes performed in Sao Paulo state in 2019, prior to the detection of SARS-CoV-2
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Impact of the COVID-19 Pandemic on Cervical Cancer Screening in São Paulo State, Brazil Acta Cytol. (IF 1.8) Pub Date : 2023-01-20
Introduction: The early identification of precursor lesions followed by appropriate treatment prevents development of cervical cancer and its consequences. Objective: The present study evaluated the influence of the COVID-19 pandemic on cervical cancer screening by comparing the quantity of tests to detect cervical cellular changes performed in São Paulo state in 2019, prior to the detection of SARS-CoV-2
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The Future Role of Cytology in Cervical Cancer Screening in the Era of HPV Vaccination Acta Cytol. (IF 1.8) Pub Date : 2023-01-16 Julieta E. Barroeta
Background: Up until recently, cervical cytology was the mainstay for cervical cancer screening. However, the established association between human papillomavirus (HPV) infection and cervical cancer has led to changes in preventive strategies with cytology being replaced by the use of high risk HPV (hrHPV) testing and primary prevention being achieved by HPV vaccination. In this context, the role of
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How to Diagnose Anaplastic Large Cell Lymphoma on Cytological Samples? A Series with Emphasis on Diagnostic Clue and Pitfalls Acta Cytol. (IF 1.8) Pub Date : 2023-01-12 Marco Montella, Stefano Lucà, Andrea Ronchi, Federica Zito Marino, Alessandro Caputo, Antonello Sica, Pio Zeppa, Renato Franco, Immacolata Cozzolino
Introduction: Anaplastic large cell lymphoma (ALCL) is a rare mature T-cell non-Hodgkin’s lymphoma characterized by large and pleomorphic neoplastic CD30-positive T cells. ALCL includes different subtypes with different clinical and biological features: systemic ALCL, primary cutaneous ALCL, breast implant-associated ALCL (BIA-ALCL). Anaplastic lymphoma kinase (ALK) is overexpressed and rearranged
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Utility of Trichorhinophalangeal Syndrome Type 1 in Malignant Effusion Cytology Acta Cytol. (IF 1.8) Pub Date : 2023-01-12
Introduction: Identifying metastatic breast carcinoma (mBC) in malignant effusion cytology (MEC) specimens is critical, as this will determine the patient’s prognosis and therapeutic management. Overlapping cytomorphologic features of breast carcinoma (BC) with other neoplastic entities makes the use of sensitive and specific markers highly desirable. Recent studies have reported trichorhinophalangeal
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Utility of TRPS1 in Malignant Effusion Cytology. Acta Cytol. (IF 1.8) Pub Date : 2023-01-12 Youley Tjendra,Nicolas Millan,Jaylou M Velez Torres,Yiqin Zuo,Monica Garcia-Buitrago,Merce Jorda,Carmen R Gomez-Fernandez
INTRODUCTION Identifying metastatic breast carcinoma (mBC) in malignant effusion cytology (MEC) specimens is critical, as this will determine the patient's prognosis and therapeutic management. Overlapping cytomorphologic features of breast carcinoma (BC) with other neoplastic entities makes the use of sensitive and specific markers highly desirable. Recent studies have reported trichorhinophalangeal
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Diagnostic Value of Epithelial Cell Adhesion Molecule Flow Cytometry for Diagnosis of Metastatic Carcinoma in Serous Effusions Acta Cytol. (IF 1.8) Pub Date : 2023-01-10 Neda Khodadadi, Maral Mokhtari
Introduction: Malignant serous effusions are common in metastatic carcinomas. Although cytomorphology is recognized as the gold standard diagnostic method, it exhibits moderate sensitivity. This study aimed to assess the diagnostic value of immunophenotyping with a single epithelial marker, known as the epithelial cell adhesion molecule (EpCAM, CD326), in discriminating malignant metastatic carcinomas
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Cytology of Benign Peritoneal Fluids and Pelvic Washing Specimens: Diagnostic Cytomorphologic Features and Pitfalls Acta Cytol. (IF 1.8) Pub Date : 2023-01-10 Gordon H. Yu, Sharon J. Song
Background: Pelvic washing and peritoneal fluid cytology specimens are used to detect peritoneal spread of malignancies. In most cases, identification of malignancy in these specimens is straightforward, but benign processes may occasionally mimic neoplasia and cause diagnostic difficulty. Summary: In this article, we perform a focused review of common benign entities encountered in pelvic washing
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Comprehensive Review of Anal Cytology Acta Cytol. (IF 1.8) Pub Date : 2023-01-10 Amanda M. Hopp, Andrii Puzyrenko, Tamara Giorgadze
Background: The incidence of anal cancer has increased over at least the past decade, with estimates of a continued increase in the coming years. Women are more commonly affected than men in the general population; separate high-risk populations have also been identified. While the pathophysiology of anal cancer is thought to be similar to its cervical counterpart, well-defined and standardized screening
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Editorial - Cytopathology in Gynecology and Gynecologic Oncology: Updates, Recent Advances, and Practical Considerations Acta Cytol. (IF 1.8) Pub Date : 2023-01-05 Julieta E. Barroeta, Ricardo R Lastra
The role of cytopathology in the diagnosis, management, and follow-up of patients with gynecologic neoplasms has expanded tremendously since the introduction of the Papanicolaou test, more than 50 years ago. Evidently, advances in HPV testing have revolutionized cervical cancer screening, which now faces new challenges in the setting of increasingly available HPV vaccines. In addition, recent changes
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Chondroblastoma: Cytomorphologic Analysis of Ten Cases with Review of the Literature Acta Cytol. (IF 1.8) Pub Date : 2023-01-04 Carla Saoud, Paul E. Wakely Jr., Liron Pantanowitz, Momin T. Siddiqui, Syed Z. Ali
Introduction: Chondroblastoma (CB) is a rare, benign cartilage-producing tumor, typically affecting the epiphysis of long bones in skeletally immature individuals. There have been only limited case reports describing the cytomorphologic features of this tumor, and thus the cytopathologic diagnostic criteria are controversial. Herein, we report the cytologic findings of 10 CB cases, discuss the diagnostic
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Overview of Ancillary Techniques in Cervical Cytology Acta Cytol. (IF 1.8) Pub Date : 2023-01-04
Background: The association between high-risk serotypes of human papillomavirus (hr-HPV) and cervical cancer is well-established. Summary: In order to improve the sensitivity of cervical cytology testing, hr-HPV testing has rapidly become part of routine cervical cancer screening, either in conjunction with cytology or as primary testing. In this review, we discuss the overall utility and strategies
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Thyroid fine needle aspiration, the Bethesda System and the BRAFV600E mutation in Papillary Thyroid Carcinoma. Association and prediction for biopsy. Acta Cytol. (IF 1.8) Pub Date : 2023-01-02 María Eugenia Galan-Garcia, Maria Soledad Martínez-Martin, Eduardo José Araujo-Ruano, Juan Francisco Loro-Ferrer, Pedro Saavedra-Santana, Eduardo Salido-Ruiz, Juan Jose Cabrera-Galván
ABSTRACT Introduction: BRAFV600E mutations have been associated with papillary thyroid carcinoma histological types including Tall-cell and Classical, peritumoral infiltration, and nuclear signs, whereas cytological features such as plump cells and sickle nuclei have also been associated with favorable thyroid FNA results for this tumor. BRAF and RAS are considered early driver mutations that contribute
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Subtyping of Non-small Cell Lung Carcinoma into Adenocarcinoma and Squamous Cell Carcinoma by Cytological Structural Features Acta Cytol. (IF 1.8) Pub Date : 2023-01-02 Kosuke Inoue, Reiji Haba, Kana Kiyonaga, Toru Matsunaga, Seiko Kagawa, Toshitetsu Hayashi, Ryou Ishikawa
Introduction: This study aimed to clarify the diagnostic structural features in cytology specimens that are useful in subtyping non-small cell lung carcinoma (NSCLC) into adenocarcinoma (ADC) and squamous cell carcinoma (SQCC). Methods: Cytology specimens (n = 233) of NSCLCs, which included ADCs (n = 149) and SQCCs (n = 84), were analyzed. The following cytological features were evaluated: isolated
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TRANSTHORACIC FINE NEEDLE ASPIRATION CYTOLOGY OF PULMONARY SPINDLE AND MESENCHYMAL NEOPLASMS: A PANDORA’S BOX Acta Cytol. (IF 1.8) Pub Date : 2022-12-29 Kanwalpreet Kaur, Trupti Patel, Sanjiban Patra, Priti Trivedi
Introduction: Pulmonary spindle cell and mesenchymal lesions are paradox for pathologists due to their rarity, overlapping morphology and differentials ranging from benign to malignant lesions, correct diagnosis is essential due to major treatment implications. This study highlights the role of fine-needle aspiration cytology (FNAC), clot core biopsy/cell block and immunohistochemistry in diagnosis
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Practical Approach to the Evaluation of Malignant Peritoneal Fluids in the Setting of Gynecologic Neoplasms Acta Cytol. (IF 1.8) Pub Date : 2022-12-26 Rachelle P Mendoza, Ricardo R. Lastra
Background: Evaluation of peritoneal fluid cytology, either from ascitic fluids or as result of peritoneal washings, is a fundamental aspect in the evaluation of women presenting with clinically concerning or histologically confirmed gynecologic neoplasms. Summary: Ascitic fluid samples are often the initial and only source of diagnostic material in women presenting with gynecologic malignancies, and
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Interobserver agreement among cytopathologists in false-negative cases by cytological diagnosis with EUS-FNA in solid pancreatic lesions Acta Cytol. (IF 1.8) Pub Date : 2022-12-20 Chen Shi, Suwen Li, Lihong non Chen, Jianglong Hong, Junjun Bao, Zhangwei Xu, Jianming Xu, Qiao Mei
Background and aims:Introduction:Early detection and accurate pathological assessment are critical to improving prognosis of pancreatic cancer.EUS has been widely used in diagnosing pancreatic lesions and can obtain histological diagnosis by EUS-FNA.However,comprehensive assessment of the interobserver agreement (IOA) among cytopathologists evaluating EUS-FNA specimens is still limited.Therefore,this
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“The impact factor of Baltimore”: Thank you the American Society of cytopathology and the International Academy of Cytology Acta Cytol. (IF 1.8) Pub Date : 2022-12-16 Mousa A. Al-Abbadi
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