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Carcinoma showing thymus‐like elements (CASTLE) with amyloid deposition in the parotid gland Pathol. Int. (IF 2.2) Pub Date : 2024-03-16 Mei Hamada, Yu Miyama, Satoko Matsumura, Yukako Shintani‐Domoto, Makoto Urano, Masanori Yasuda
Carcinoma showing thymus‐like elements (CASTLE) is a rare tumor that commonly occurs in the thyroid gland. Extrathyroidal CASTLE is rarer, and only 11 cases of CASTLE of major salivary glands have been reported to date. We report the first case of amyloid deposition in parotid CASTLE. A 63‐year‐old man presented with a slowly growing mass in the left parotid region. Computed tomography revealed an
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Molecular pathological approach to cancer epigenomics and its clinical application Pathol. Int. (IF 2.2) Pub Date : 2024-03-14 Yae Kanai
Careful microscopic observation of histopathological specimens, accumulation of large numbers of high‐quality tissue specimens, and analysis of molecular pathology in relation to morphological features are considered to yield realistic data on the nature of multistage carcinogenesis. Since the morphological hallmark of cancer is disruption of the normal histological structure maintained through cell−cell
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Evaluation of pancreatic cancer specimens for comprehensive genomic profiling Pathol. Int. (IF 2.2) Pub Date : 2024-03-13 Kota Washimi, Yukihiko Hiroshima, Shinya Sato, Makoto Ueno, Satoshi Kobayashi, Naoto Yamamoto, Chie Hasegawa, Emi Yoshioka, Kyoko Ono, Yoichiro Okubo, Tomoyuki Yokose, Yohei Miyagi
Inadequate specimen quality or quantity hinders comprehensive genomic profiling in identifying actionable mutations and guiding treatment strategies. We investigated the optimal conditions for pancreatic cancer specimen selection for comprehensive genomic profiling. We retrospectively analyzed 213 pancreatic cancer cases ordered for comprehensive genomic profiling and compared results from pancreatic
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Papillary renal neoplasm with reverse polarity is biologically and clinically distinct from eosinophilic papillary renal cell carcinoma Pathol. Int. (IF 2.2) Pub Date : 2024-03-08 Vincent Francis Castillo, Kiril Trpkov, Theodorus Van der Kwast, Fabio Rotondo, Malek Hamdani, Rola Saleeb
Papillary renal neoplasm with reverse polarity (PRNRP) is a recently described indolent entity with distinct features and its recognition from other oncocytic/eosinophilic papillary renal cell carcinoma (ePRCC) has important prognostic implications. ABCC2, a renal drug transporter, is overexpressed in aggressive PRCCs. In this study, we compared the clinicopathological parameters and the biological
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Late relapsing testicle cancer identified with isochromosome 12p (i12p) fluorescence in situ hybridization (FISH) analysis Pathol. Int. (IF 2.2) Pub Date : 2024-02-29 Teruki Isobe, Noriyasu Kawai, Maria Aoki, Toshiharu Morikawa, Masakazu Gonda, Nami Tomiyama, Takashi Nagai, Keitaro Iida, Toshiki Etani, Taku Naiki, Toyonori Tsuzuki, Takahiro Yasui
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Carcinogenesis caused by transcription‐coupled DNA damage through GANP and other components of the TREX‐2 complex Pathol. Int. (IF 2.2) Pub Date : 2024-02-27 Yasuhiro Sakai, Kazuhiko Kuwahara
Perturbation of genes is important for somatic hypermutation to increase antibody affinity during B‐cell immunity; however, it may also promote carcinogenesis. Previous studies have revealed that transcription is an important process that can induce DNA damage and genomic instability. Transciption‐export‐2 (TREX‐2) complex, which regulates messenger RNA (mRNA) nuclear export, has been studied in the
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JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure Pathol. Int. (IF 2.2) Pub Date : 2024-02-27 Mingming Ren, Xiaoqiang Ye, Chun Ouyang, Qing'en Da, Weiwei Xue, Piji Chen
The importance of mitochondrial dysfunction and oxidative stress has been indicated in the progression of heart failure (HF). The molecular mechanisms, however, remain to be fully elucidated. This study aimed to explore the role and underlying mechanism of secreted frizzled‐related protein 4 (SFRP4) in these two events in HF. Mice with HF were developed using transverse aortic constriction, and hematoxylin‐eosin
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Yin Yang 1 facilitates the activation, inflammation, and extracellular matrix deposition of hepatic stellate cells in hepatic fibrosis Pathol. Int. (IF 2.2) Pub Date : 2024-02-14 Xiao Fu, Xin Luo, Ping Xiao, Ninghong Guo
Chronic hepatic diseases often involve fibrosis as a pivotal factor in their progression. This study investigates the regulatory mechanisms of Yin Yang 1 (YY1) in hepatic fibrosis. Our data reveal that YY1 binds to the prolyl hydroxylase domain 1 (PHD1) promoter. Rats treated with carbon tetrachloride (CCl4) display heightened fibrosis in liver tissues, accompanied by increased levels of YY1, PHD1
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MicroRNA-196a-5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma Pathol. Int. (IF 2.2) Pub Date : 2024-01-30 Dubiao Xian, Shubo Yang, Yunzhong Liu, Qingfeng Liu, Ding Huang, Yuechang Wu
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy affecting the digestive tract, with an increasing incidence rate worldwide. Recently, numerous studies revealed that microRNAs were associated with gene expression regulation, particularly their involvement in the regulation of tumor cells, garnering widespread attention. Here, we discovered that miR-196a-5p was significantly upregulated
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Identification of uromodulin deposition in the stroma of perinephric fibromyxoid nephrogenic adenoma by mass spectrometry Pathol. Int. (IF 2.2) Pub Date : 2024-01-30 Kaori Yoshimura, Yukinobu Ito, Mina Suzuki, Masafumi Horie, Takumi Nishiuchi, Yukako Shintani-Domoto, Kazuyoshi Shigehara, Hiroko Oshima, Masanobu Oshima, Akiteru Goto, Takayuki Nojima, Tsuzuki Toyonori, Atsushi Mizokami, Hiroko Ikeda, Daichi Maeda
Nephrogenic adenoma (NA) is an epithelial lesion that usually occurs in the mucosa of the urinary tract. Rare cases of deep infiltrative or perinephric lesions have also been reported. Recently, NA with characteristic fibromyxoid stroma (fibromyxoid NA) has been proposed as a distinct variant. Although shedding of distal renal tubular cells due to urinary tract rupture has been postulated as the cause
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Pseudoimmunofluorescent immunohistochemistry image analysis of phosphorylated signaling proteins in human esophageal squamous cell carcinoma tissue Pathol. Int. (IF 2.2) Pub Date : 2024-01-23 Mari Nishio, Shuichi Tsukamoto, Takayuki Kodama, Manabu Shigeoka, Yu-ichiro Koma, Hiroshi Yokozaki
Immunohistochemistry is primarily employed to visualize the localization of specific molecules in tissue samples. However, there is an increasing need for software-assisted quantitative assessment. In the present study, we performed inverted blue channel-based pseudoimmunofluorescence image analysis using original immunohistochemistry images. In human esophageal squamous cell carcinoma tissues, various
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Erianin inhibits tumor growth by promoting ferroptosis and inhibiting invasion in hepatocellular carcinoma through the JAK2/STAT3/SLC7A11 pathway Pathol. Int. (IF 2.2) Pub Date : 2024-01-19 Liyan Chen, Rongrong Sun, Kun Fang
Iron has been found to be involved in the tumor cell proliferation process, which can lead to the increased sensitivity of cancer cells to ferroptosis. Since erianin is associated with oxidative stress in hepatocellular carcinoma (HCC), we hypothesized that the therapeutic effect and mechanism of erianin on HCC is related to ferroptosis. HCC cells were stimulated with increase of erianin concentrations
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Enterocolic granulomatous phlebitis associated with epidermal growth factor-containing fibulin-like extracellular matrix protein 1 deposition and focal amyloid properties: A case report Pathol. Int. (IF 2.2) Pub Date : 2024-01-19 Shojiro Ichimata, Akane Aikawa, Naonori Sugishita, Nagaaki Katoh, Fuyuki Kametani, Hibiki Tagawa, Yusuke Handa, Masahide Yazaki, Yoshiki Sekijima, Takashi Ehara, Naoki Nishida, Shin Ishizawa
A woman in her 60s with rheumatoid arthritis was admitted with fever and abdominal pain. Laparoscopic examination with the differential diagnosis of peritoneal neoplasm and infection revealed granulomatous phlebitis in the resected greater omentum. Amorphous eosinophilic deposits observed in the resected tissue exhibited focal, weak positivity for Congo red but were strongly positive for thioflavin
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Impact of the quality of resected thyroid cancer tissue sample on next-generation sequencing testing Pathol. Int. (IF 2.2) Pub Date : 2024-01-16 Kanako C. Hatanaka, Kenichi Nakamura, Ryohei Katoh, Koichi Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Yoshihiro Matsuno, Satoshi Kano, Yui Okada, Joji Mori, Yoichi M. Ito, Yutaka Hatanaka
Activating rearranged during transfection (RET) proto-oncogene alterations can be identified using next-generation sequencing (NGS) of tumor DNA/RNA. We assessed factors associated with NGS (Oncomine Dx Target Test [ODxTT]) success for resected thyroid cancer (TC) specimens, including sample age, processing conditions, and DNA/RNA quality. TC samples were from three Japanese hospitals, with sample
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Decoding the DNA methylome of central nervous system tumors: An emerging modality for integrated diagnosis Pathol. Int. (IF 2.2) Pub Date : 2024-01-15 Kaishi Satomi, Koichi Ichimura, Junji Shibahara
The definitive diagnosis and classification of individual cancers are crucial for patient care and cancer research. To achieve a robust diagnosis of central nervous system (CNS) tumors, a genotype-phenotype integrated diagnostic approach was introduced in recent versions of the World Health Organization classification, followed by the incorporation of a genome-wide DNA methylome-based classification
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The first autopsy case of Epstein–Barr virus-positive marginal zone lymphoma that deteriorated after COVID-19 vaccination Pathol. Int. (IF 2.2) Pub Date : 2023-12-20 Ziyao Wang, Reiji Muto, Hiroaki Miyoshi, Mikiko Aoki, Noriko Uesugi, Hiroyuki Murayama, Kosuke Masutani, Makoto Hamasaki
This is the first autopsy case of Epstein–Barr virus-positive marginal zone lymphoma (EBV + MZL) with an other iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPD) (methotrexate [MTX]-associated LPD) that deteriorated after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. This case had a unique immunophenotype. A 71-year-old female patient with rheumatoid
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Colostomy-site carcinoma with primitive phenotype in a rectal cancer patient after achieving pathological complete response with neoadjuvant chemoradiotherapy Pathol. Int. (IF 2.2) Pub Date : 2023-12-22 Takayuki Kodama, Maki Kanzawa, Hiroshi Hasegawa, Shuichi Tsukamoto, Mari Nishio, Manabu Shigeoka, Yu-ichiro Koma, Tomoo Itoh, Hiroshi Yokozaki
Herein, we report a rare case of a carcinoma with primitive phenotype (enteroblastic and/or hepatoid differentiation) occurring at a colostomy site. The patient was an elderly male who underwent neoadjuvant chemoradiotherapy for rectal cancer, followed by abdominoperineal resection. A biopsy specimen for the rectal carcinoma before neoadjuvant chemoradiotherapy was conventional tubular adenocarcinoma
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Epidemiological study of the subtype frequency of systemic amyloidosis listed in the Annual of the Pathological Autopsy Cases in Japan Pathol. Int. (IF 2.2) Pub Date : 2023-12-13 Aina Yamaguchi, Masayoshi Tasaki, Mitsuharu Ueda, Yukio Ando, Hironobu Naiki
Clinical presentation of systemic amyloidosis differs among subtypes, and accurate subtype classification is important for choosing the treatment. Amyloid transthyretin (ATTR) amyloidosis was the predominant among the recently consulted amyloidosis cases in Japan. To reveal the latest subtype frequency of systemic amyloidosis among autopsy cases in Japan. We analyzed systemic amyloidosis cases autopsied
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Prevalence and diagnostic significance of non-invasive follicular thyroid neoplasm with papillary-like nuclear features in Japan—A multi-institutional study Pathol. Int. (IF 2.2) Pub Date : 2023-12-05 Mitsuyoshi Hirokawa, Masahiro Ito, Noriko Motoi, Tomohiro Chiba, Yoshiaki Imamura, Hironao Yasuoka, Rumi Hino, Miyoko Higuchi, Akira Miyauchi, Takashi Akamizu
This multi-institutional study investigated non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) frequency and its diagnostic significance in Japan. We reviewed 4008 thyroid nodules resected in six institutions before NIFTP was proposed. Overall, 26 cases diagnosed as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) and 145 cases of
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Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers Pathol. Int. (IF 2.2) Pub Date : 2023-12-05 Sunao Ito, Akira Koshino, Masayuki Komura, Shunsuke Kato, Takahiro Otani, Chengbo Wang, Akane Ueki, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma
The present study analyzed the expression of five independent immunohistochemical markers, CD4, CD8, CD66b, CD68, and CD163, on immune cells within the colorectal cancer (CRC) tumor microenvironment (TME). Using hierarchical clustering, patients were successfully classified according to significant associations with clinicopathological features and/or survival. Patients with mismatch repair-proficient
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The CAP: Your resource for artificial intelligence information Pathol. Int. (IF 2.2) Pub Date : 2023-12-01 Emily E. Volk
Artificial intelligence (AI) has become increasingly studied and implemented in some pathology departments; but how might AI models help change medicine? While technology leaders are calling for a pause on developing AI systems until there is greater confidence “that their effects will be positive and their risks will be manageable,” (Pause Giant AI Experiments: An Open Letter. March 22, 2023. https://futureoflife
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Distribution of proteinase K-resistant anti-α-synuclein immunoreactive axons in the cardiac plexus is unbiased to the left ventricular anterior wall Pathol. Int. (IF 2.2) Pub Date : 2023-12-01 Nei Fukasawa, Miku Maeda, Yoshifumi Sugiyama, Takahiro Fukuda, Masayuki Shimoda
Lewy body disease (LBD) is characterized by the appearance of Lewy neurites and Lewy bodies, which are predominantly composed of α-synuclein. Notably, the cardiac plexus (CP) is one of the main targets of LBD research. Although previous studies have reported obvious differences in the frequency of Lewy body pathology (LBP) in the CP, none of them have confirmed whether LBP preferably appears in any
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Epithelioid granulomas with proliferating T-lymphocytes in bone marrow in a patient with infectious mononucleosis modified by secondary hemophagocytic lymphohistiocytosis. Pathol. Int. (IF 2.2) Pub Date : 2023-11-17 Haruo Ohtani,Yoshihiro Sato,Isho Izumi,Keisuke Kato,Masahiro Tsuchida
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Mechanisms underlying retardation of aging by dietary energy restriction Pathol. Int. (IF 2.2) Pub Date : 2023-11-17 Isao Shimokawa
Moderate restriction of dietary energy intake, referred to here as dietary restriction (DR), delays aging and extends lifespan in experimental animals compared with a diet of ad libitum feeding (AL) control animals. Basic knowledge of the mechanisms underlying the effects of DR could be applicable to extending the healthspan in humans. This review highlights the importance of forkhead box O (FoxO)
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Influence of formalin fixation duration on RNA quality and quantity from formalin-fixed paraffin-embedded hepatocellular carcinoma tissues Pathol. Int. (IF 2.2) Pub Date : 2023-11-07 Kenji Amemiya, Yosuke Hirotsu, Yuki Nagakubo, Hitoshi Mochizuki, Toshio Oyama, Masao Omata
Analyzing RNA samples from formalin-fixed paraffin-embedded (FFPE) tissues is essential for precision medicine. We investigated RNA quantity and quality from FFPE tumor tissues fixed in formalin for various times and compared sequencing metrics from next-generation sequencing (NGS). Hepatocellular carcinoma (HCC) tissues were fixed in 10% neutral buffered formalin (1–240 h) and FFPE blocks were prepared
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Large cell neuroendocrine carcinoma with discohesive growth pattern of the sigmoid colon resembling undifferentiated carcinoma. Pathol. Int. (IF 2.2) Pub Date : 2023-10-27 Rin Yamada,Osamu Nakahara,Hiroshi Takamori,Yoshihiro Komohara,Minako Fujiwara
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Donepezil attenuates inflammation and apoptosis in ulcerative colitis via regulating LRP1/AMPK/NF-κB signaling Pathol. Int. (IF 2.2) Pub Date : 2023-10-13 Angqing Li, Junyi Zhang, Ke Chen, Jian Wang, Aman Xu, Zhengguang Wang
This article focuses on the specific effects and mechanisms of donepezil (DNPZ) hydrochloride on inflammation and apoptosis in ulcerative colitis (UC). In vivo and in vitro models of UC were established using dextran sodium sulfate (DSS)-induced mice and NCM460 cells, respectively. Following oral administration of DNPZ, body weight, disease activity index (DAI) scores and colon lengths of mice were
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Pulmonary interstitial glycogenosis in Birt-Hogg-Dubé syndrome-associated lung cysts: A new insight into the pathogenesis? Pathol. Int. (IF 2.2) Pub Date : 2023-10-11 Riken Kawachi, Yukio Nakatani, Mitsuko Furuya, Naoya Nakamura, Yusuke Kondo, Yoji Nagashima, Tomohiro Nakayama, Masahiro Okada, Hiroyuki Sakurai, Shinobu Masuda
Multiple lung cysts are one of the major features of Birt-Hogg-Dubé syndrome (BHD), but little is known about their nature and pathogenesis. We report a case of a woman diagnosed with BHD lung cysts who exhibited pulmonary interstitial glycogenosis (PIG), a mesenchymal abnormality hitherto undescribed in this disease, in specimens resected at 14 and 29 years of age. Histopathologically, oval to spindle
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Endocrine cell generation in obstructive chronic pancreatitis in humans: A phenomenon of acinar cell plasticity. Pathol. Int. (IF 2.2) Pub Date : 2023-10-03 Stratigoula Sakellariou,Kostas Palamaris,Nikolaos Kavantzas,Evangelos Felekouras,Ioanna Delladetsima
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Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of “metabolism-based pathology” Pathol. Int. (IF 2.2) Pub Date : 2023-09-27 Kenta Masui, Paul S. Mischel
Molecular genetic approaches are now mandatory for cancer diagnostics, especially for brain tumors. Genotype-based diagnosis has predominated over the phenotype-based approach, with its prognostic and predictive powers. However, comprehensive genetic testing would be difficult to perform in the clinical setting, and translational research is required to histologically decipher the peculiar biology
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Proposal for combined macroscopic and microscopic on-site evaluation (cMOSES) of fresh tissue from liver tumor biopsies for histopathological diagnosis and comprehensive genomic panel testing. Pathol. Int. (IF 2.2) Pub Date : 2023-09-13 Tami Nagatani,Yoji Wani,Soichiro Fushimi,Yu Matsuo,Shiho Murakami,Toshifumi Tada,Shinichiro Nakamura,Hirofumi Inoue,Maki Tanioka,Hiroyuki Okada,Akira Hirasawa
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Endometrial gastric-type mucinous carcinoma: A clinicopathological study of an unfavorable histological type of endometrial carcinoma. Pathol. Int. (IF 2.2) Pub Date : 2023-09-06 Fumi Kawakami,Ken Yamaguchi,Sachiko Minamiguchi,Tamotsu Sudo,Takanori Hirose,Norihiro Teramoto,Yoshiki Mikami
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A case of diffuse goblet cell adenocarcinoma of the appendix showing carcinoid-like expansion. Pathol. Int. (IF 2.2) Pub Date : 2023-09-01 Daichi Yamakawa,Shu Yuguchi,Arinobu Yoshinaga,Junichiro Ikeda,Masayuki Noguchi
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Lymphoepithelial cyst of the parotid gland may be an alternative histogenetic pathway of Warthin tumor. Pathol. Int. (IF 2.2) Pub Date : 2023-08-28 Shinnichi Sakamoto,Fumio Ide,Miyako Hoshino,Michiko Nishimura,Tsutomu Nomura,Kentaro Kikuchi
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Tumor heterogeneity from the viewpoint of pathologists Pathol. Int. (IF 2.2) Pub Date : 2023-08-28 Eiichi Morii
Morphological and functional heterogeneity are found in tumors, with the latter reflecting the different levels of resistance against antitumor therapies. In a therapy-resistant subpopulation, the expression levels of differentiation markers decrease, and those of immature markers increase. In addition, this subpopulation expresses genes involved in drug metabolism, such as aldehyde dehydrogenase 1A1
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Primary cellular schwannoma of the kidney Pathol. Int. (IF 2.2) Pub Date : 2023-08-28 Xiaojing An, Jiong Liu, Bin Yang, Wei Zhang, Xiaoxia Dong
Cellular schwannoma (CS), first reported by Woodruff in 1981,1 is an uncommon tumor derived from the Schwann cells of the peripheral nerves. Anatomically, schwannomas have a wide distribution, but the most frequent locations include the subcutaneous tissues of the extremities, head and neck regions, and retroperitoneal and mediastinal soft tissues. Primary CS of the kidneys is rare, and there are no
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PTEN loss in intraductal carcinoma of the prostate has low incidence in Japanese patients Pathol. Int. (IF 2.2) Pub Date : 2023-08-23 Takanori Ito, Taishi Takahara, Natsuki Taniguchi, Yuki Yamamoto, Akira Satou, Akiko Ohashi, Emiko Takahashi, Naoto Sassa, Toyonori Tsuzuki
Clinical and genomic features of prostate cancer (PCa) vary considerably between Asian and Western populations. PTEN loss is the most frequent abnormality in intraductal carcinoma of the prostate (IDC-P) in Western populations. However, its prevalence and significance in Asian populations have not yet been well studied. In the present study, we evaluated PTEN expression in IDC-P in a Japanese population
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A novel FET-ETS family fusion (FUS::FLI1) in a case of Ewing sarcoma. Pathol. Int. (IF 2.2) Pub Date : 2023-08-22 Pranav Dorwal,Duncan Lambie,Andrew Dettrick,Anna F N Goh,Beena Kumar,Peter Manders
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Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of pleural origin. Pathol. Int. (IF 2.2) Pub Date : 2023-08-22 Yuya Urano,Kennosuke Karube,Yukihiro Shiraki
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A case of lung carcinoma with a unique biphasic feature: Implications for histogenesis of “fake mucoepidermoid carcinoma” developing in the peripheral lung Pathol. Int. (IF 2.2) Pub Date : 2023-08-22 Eita Kumagai, Mai Matsumura, Ikuma Kato, Hiromasa Arai, Takehisa Suzuki, Misaki Sugiyama, Motoki Sekiya, Hideaki Mitsui, Toshiaki Kataoka, Hiromichi Iwashita, Koji Okudela
We present a case of lung carcinoma with a unique biphasic feature. The patient was a 67-year-old male smoker with idiopathic pulmonary fibrosis (IPF). A subpleural tumor in the left lower lobe, embedded in fibrotic tissue, was resected. Histologically, the tumor consisted of major and minor components of mucoepidermoid carcinoma (MEC) and surrounding conventional lepidic adenocarcinoma, respectively
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Effect of mitochondrial quantity and quality controls in white adipose tissue on healthy lifespan: Essential roles of GH/IGF-1-independent pathways in caloric restriction-mediated metabolic remodeling Pathol. Int. (IF 2.2) Pub Date : 2023-08-22 Yuina Otani, Yuka Nozaki, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami
Long-term caloric restriction is a conventional and reproducible dietary intervention to improve whole body metabolism, suppress age-related pathophysiology, and extend lifespan. The beneficial actions of caloric restriction are widely accepted to be regulated in both growth hormone/insulin-like growth factor 1-dependent and -independent manners. Although growth hormone/insulin-like growth factor 1-dependent
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Lowered IL-37 gene expression and elevated IL-37-producing tissue-resident immune cells in psoriasis lesional biopsies Pathol. Int. (IF 2.2) Pub Date : 2023-08-17 Aini Wulamujiang, Seyma Ozkanli, Ender Coskunpinar, Halime Tuba Canbaz, Gamze Yesilay, Muhammetnur Tekayev, Kubra Sevgin
Psoriasis is an immune cell-dependent chronic autoimmune skin disorder. Interleukin 37 (IL-37) is a cytokine belonging to the IL-1 family that shows anti-inflammatory and protective effects in various mouse models of psoriasis. Even though various animal models are used to investigate the pathogenic mechanisms of psoriasis, human clinical studies are still needed to make up for the deficiencies, as
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Clinicopathological significance of TUBB3 in upper tract urothelial carcinoma and possible application in urine cytology Pathol. Int. (IF 2.2) Pub Date : 2023-08-17 Go Kobayashi, Tetsutaro Hayashi, Kazuhiro Sentani, Naohiro Uraoka, Takafumi Fukui, Aya Kido, Narutaka Katsuya, Akira Ishikawa, Takashi Babasaki, Yohei Sekino, Hiroyuki Nose, Nobuyuki Hinata, Naohide Oue
βIII-Tubulin, encoded by the TUBB3 gene, is a microtubule protein. We previously reported that TUBB3 is overexpressed in renal cell carcinoma. We investigated the clinicopathological significance of TUBB3 in upper tract urothelial carcinoma (UTUC) by immunohistochemistry. In normal tissue, TUBB3 expression was weak or absent. In contrast, TUBB3 overexpression was observed in urothelial carcinoma (UC)
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The prognostic impact of a high number of peritumoral alveolar macrophages in neuroendocrine carcinoma in the lung Pathol. Int. (IF 2.2) Pub Date : 2023-08-17 Takehiko Tanaka, Shigeki Umemura, Tomohiro Miyoshi, Tokiko Nakai, Osamu Noritake, Jun Suzuki, Kenta Tane, Joji Samejima, Keiju Aokage, Sachiyo Mimaki, Katsuya Tsuchihara, Tetsuro Taki, Saori Miyazaki, Reiko Watanabe, Shingo Sakashita, Naoya Sakamoto, Motohiro Kojima, Koichi Goto, Norihiko Ikeda, Masahiro Tsuboi, Genichiro Ishii
Alveolar macrophages (AMs) are resident macrophages in the lungs; however, whether the number of AMs plays a role in the lung neuroendocrine tumor (NET) prognosis remains unclear. We counted the number of AMs located around the tumor (peritumoral alveolar macrophages [pAMs]) and the number of AMs located apart from the tumor (distant macrophages; dAMs). In 73 cases of neuroendocrine carcinoma (NEC:
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The risk of weekend biopsy: Impact of specimen source and fixation status on HER2 assessment in the treatment of advanced gastric cancer (The HER_WEEKEND study) Pathol. Int. (IF 2.2) Pub Date : 2023-08-17 Michio Nakamura, Ayako Watanabe, Aki Yoshizawa, Sari Iwasaki, Asako Nomura, Mariko Matsumura, Taichi Murai, Kazufumi Itaya, Yuta Koike, Takaaki Izumi, Ayana Endo, Shin Kato, Yuji Ono, Takahiro Ohshima, Nanase Okazaki, Shimpei Nakagawa, Yasushi Ishii, Yuichiro Fukasawa, Isao Yokota, Takahiro Tsuji, Shuji Nishikawa
Accurate evaluation of human epidermal growth factor receptor type 2 (HER2) expression is crucial for determining chemotherapy regimens in gastric cancer. However, formalin fixation status has been identified as an important factor affecting HER2 assessment reliability. This retrospective cohort study aimed to investigate the correlation between sample collection day (weekday vs. weekend) and source
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Endotheliopathy of liver sinusoidal endothelial cells in liver disease Pathol. Int. (IF 2.2) Pub Date : 2023-08-17 Reiichiro Kondo, Yasuko Iwakiri, Masayoshi Kage, Hirohisa Yano
Liver is the largest solid organ in the abdominal cavity, with sinusoid occupying about half of its volume. Under liver disease, hemodynamics in the liver tissue dynamically change, resulting in injury to liver sinusoidal endothelial cells (LSECs). We discuss the injury of LSECs in liver diseases in this article. Generally, in noninflamed tissues, vascular endothelial cells maintain quiescence of circulating
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Gastric juvenile polyposis syndrome with inflammatory changes in the intervening mucosa Pathol. Int. (IF 2.2) Pub Date : 2023-08-09 Mitsuhiro Nikaido, Takafumi Takimoto, Takaki Sakurai, Masahito Hoki, Sachiko Minamiguchi, Takeshi Nakajima, Masako Torishima, Tatsuto Nishigori, Kazutaka Obama, Yukari Koyama, Tsutomu Chiba, Mineko Ushiama, Masahiro Gotoh, Mari Teramura, Haruhiko Takeda, Takahiro Shimizu, Hiroshi Seno
Juvenile polyposis syndrome (JPS) is an autosomal dominant inherited disorder characterized by multiple hamartomatous polyps in the gastrointestinal tract, and is caused by germline mutations in SMAD4 or BMPR1A. 1 However, no pathogenic variant is found in 40% of cases, and one-fourth of cases occur without a family history. Multiple polyps are typically found in the colon (98%), stomach (14%), duodenum
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Secondary Budd-Chiari syndrome caused by adult T-cell leukemia/lymphoma. Pathol. Int. (IF 2.2) Pub Date : 2023-08-02 Ryutaro Tominaga,Kazuki Yoshimura,Masakatsu Kawamura,Shinichi Kako,Yoshinobu Kanda,Haruka Morikawa,Shiori Ando,Naota Okabe,Masahiro Hiruta,Akira Tanaka,Hisashi Oshiro
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The role of nonlinear dimension reduction of genome-wide DNA methylome in integrated diagnosis: A case study of glioblastoma, IDH-wildtype. Pathol. Int. (IF 2.2) Pub Date : 2023-08-02 Kaishi Satomi,Kuniaki Saito,Hiroaki Shimoyamada,Hiromi Onizuka,Takahiro Shibayama,Takashi Hibiya,Akimasa Hayashi,Kiyotaka Nagahama,Yuki Yamagishi,Nobuyoshi Sasaki,Keiichi Kobayashi,Miho Gomyo,Motoo Nagane,Junji Shibahara
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Mixed epithelial and stromal tumor synchronously detected in bilateral kidneys with end-stage renal failure. Pathol. Int. (IF 2.2) Pub Date : 2023-08-02 Hiroki Kiyokawa,Takahiro Matsui,Masako Kurashige,Shinichiro Tahara,Toyonori Tsuzuki,Eiichi Morii
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Constant small-cell changes and variable LEF1 expression in DUSP22-rearranged primary cutaneous anaplastic large-cell lymphoma: Analysis of the repeated biopsies of three patients Pathol. Int. (IF 2.2) Pub Date : 2023-08-02 Akio Osakada, Masakazu Fujimoto, Chiyuki Ueshima, Yo Kaku, Momoko Nishikori, Norihito Inoue, Kengo Takeuchi, Hironori Haga
DUSP22-rearranged primary cutaneous anaplastic large-cell lymphoma (pcALCL) has a biphasic histological pattern defined by large dermal atypical lymphocytes and epidermotropic small lymphocytes resembling pagetoid reticulosis, but the positivity rate of the biphasic pattern in DUSP22-rearranged pcALCL is unknown. Immunohistochemically, LEF1 expression in >75% of tumor cells is associated with DUSP22-rearrangement
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Gastric succinate dehydrogenase-deficient gastrointestinal stromal tumor presenting as a solitary cystic lesion. Pathol. Int. (IF 2.2) Pub Date : 2023-07-28 Hirotsugu Hashimoto,Sakiko Miura,Motomu Tanaka,Jun Sakuma,Yuji Fujita,Manabu Takamatsu,Tamaki Noie,Teppei Morikawa
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Paragonimus westermani preadult fluke in a pulmonary necrotizing granulomatous lesion: A case associated with eating soy sauce-marinated raw freshwater crab, "gejang". Pathol. Int. (IF 2.2) Pub Date : 2023-07-26 Kazunari Maekawa,Eiji Nagayasu,Youichi Hata,Fumio Hanamure,Haruhiko Maruyama,Atsushi Yamashita
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Clinical impact of perineural cancer invasion detected in prostate cores: Involvement of spatially contiguous versus separate biopsy sites. Pathol. Int. (IF 2.2) Pub Date : 2023-07-26 Yuki Teramoto,Numbereye Numbere,Hiroshi Miyamoto
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Focal glioneuronal differentiation in an atypical teratoid/rhabdoid tumor after chemoradiotherapy. Pathol. Int. (IF 2.2) Pub Date : 2023-07-26 Makiko Yoshida,Atsuro Saito,Daiichiro Hasegawa,Yoshiyuki Kosaka,Junji Koyama,Atsufumi Kawamura,Yoshinobu Akasaka,Toshinori Soejima
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Circ_0001955 promotes non-small cell lung cancer cell proliferation and invasion by regulating MiR-29a-3p/NKIRAS2 axis to activate the nuclear factor-κB pathway Pathol. Int. (IF 2.2) Pub Date : 2023-07-21 Xia Zhou, Guoqin Qiu, Yang Yang, Wuan Bao, Danhong Zhang, Xianghui Du
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors worldwide. Circular RNAs (circRNAs) have been widely reported to play a role in the pathogenesis of various tumors. Nevertheless, the function of circ_0001955 in NSCLC progression has not been explored yet. This study aims to explore the functions of circ_0001955 in NSCLC and investigate its regulatory molecular mechanism
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Emerging roles of transmembrane-type tight junction proteins in cancers Pathol. Int. (IF 2.2) Pub Date : 2023-07-14 Akira Takasawa, Kumi Takasawa, Masaki Murata, Makoto Osanai, Norimasa Sawada
Tight junctions (TJs) are the most apical components of the cell–cell adhesion machinery in epithelial and endothelial cells and they play essential roles in homeostasis. Recent studies have revealed that aberrant expression of tight junction proteins (TJPs) is frequently observed in various type of cancers. Here we review cancer-associated aberrant expression of TJPs with focus on transmembrane-type
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Ghost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor, peripheral: A case report Pathol. Int. (IF 2.2) Pub Date : 2023-07-04 Shinnichi Sakamoto, Toshinori Ando, Kuniko Mizuta, Shigehiro Ono, Masaru Konishi, Mutsumi Miyauchi, Ikuko Ogawa
Ghost cell odontogenic carcinoma (GCOC) is an extremely rare intraosseous malignant odontogenic tumor with prominent ghost cell keratinization and dentinoid formation. Here, we present the first case of GCOC arising in dentinogenic ghost cell tumor (DGCT), peripheral. The patient was a man in his 60s with an exophytic mass in the anterior part of lower gingiva. The resected tumor measured 4.5 cm in
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Vimentin-positive invasive breast carcinoma of no special type: A breast carcinoma with lethal biological characteristics Pathol. Int. (IF 2.2) Pub Date : 2023-06-28 Yuki Ichinose, Takahiro Hasebe, Masataka Hirasaki, Ayaka Sakakibara, Hideki Yokogawa, Asami Nukui, Miyuki Hiratsuka, Akihiro Fujimoto, Chihiro Iso, Noriko Wakui, Satomi Shibasaki, Koichi Kamada, Nobuyuki Suzuki, Yasuo Kamakura, Masanori Yasuda, Asano Aya, Hiroko Shimada, Kazuo Matsuura, Hiroshi Ishiguro, Akihiko Osaki, Toshiaki Saeki
Vimentin is a stable mesenchymal immunohistochemical marker and is widely recognized as a major marker of mesenchymal tumors. The purpose of the present study was to investigate if the vimentin expression status might serve as a significant predictor of outcomes in patients with invasive breast carcinoma of no special type (IBC-NST) and to investigate, by comprehensive RNA sequencing analyses, the
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Possible roles of human mast cells in the formation of xanthelasma palpebrarum Pathol. Int. (IF 2.2) Pub Date : 2023-06-21 Hiroya Nakamura, Takashi Matsuzaki, Ken R. Ito, Ryota Nakagawa, Lurica M. Asano, Hinako Nishikido, Hironori Haga, Tatsuki R. Kataoka
Cutaneous xanthoma consist of foam cells that originate from monocytes or macrophages and accumulate in perivascular areas of the skin. The main component of these cells is oxidized low-density lipoprotein (oxLDL). In this study, we show that mast cells surround the accumulated foam cells, suggesting their involvement in xanthoma formation. Coculture of THP-1 or U937 monocytes with the human mast cell