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TBX15 and SDHB expression changes in colorectal cancer serve as potential prognostic biomarkers Exp. Mol. Pathol. (IF 3.6) Pub Date : 2024-02-22 Melika Golozar, Ali Valipour Motlagh, Mohammad Mahdevar, Maryam Peymani, Kolsoum InanlooRahatloo, Kamran Ghaedi
Alterations in the expression of certain genes could be associated with both patient mortality rates and drug resistance. This study aimed to identify genes in colorectal cancer (CRC) that potentially serve as hub genes influencing patient survival rates. RNA-Seq data were downloaded from the cancer genome atlas database, and differential expression analysis was performed between tumors and healthy
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Molecular and cellular pruritus mechanisms in the host skin Exp. Mol. Pathol. (IF 3.6) Pub Date : 2024-02-07 Li Li, Zhi-en Li, Yun-li Mo, Wan-yao Li, Hui-jing Li, Guang-hai Yan, Xiang-zheng Qin, Li-hua Piao
Pruritus, also known as itching, is a complex sensation that involves the activation of specific physiological and cellular receptors. The skin is innervated with sensory nerves as well as some receptors for various sensations, and its immune system has prominent neurological connections. Sensory neurons have a considerable impact on the sensation of itching. However, immune cells also play a role
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Interleukin 6 polymorphisms are associated with cardiovascular risk factors in premature coronary artery disease patients and healthy controls of the GEA Mexican study Exp. Mol. Pathol. (IF 3.6) Pub Date : 2024-02-01 Rosalinda Posadas-Sánchez, Ángel Rene López-Uribe, José Manuel Fragoso, Gilberto Vargas-Alarcón
Interleukin-6 (IL-6) is an acute-phase protein that plays an important role in the inflammatory response, vascular inflammation, and atherosclerosis process. The study aimed to establish whether gene polymorphisms and IL-6 concentrations are associated with premature coronary artery disease (pCAD) and cardiovascular risk factors. The IL-6 concentrations and the rs2069827, rs1800796, and rs1800795 IL-6
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CD10 expression as a potential predictor of pathological complete response in ER-negative and triple-negative breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy Exp. Mol. Pathol. (IF 3.6) Pub Date : 2024-01-29 George Dimitrov, Sami Shousha, Petranka Troianova
Background Neoadjuvant chemotherapy (NCT) can induce a pathological complete response (pCR) in breast cancer patients, leading to improved outcomes. However, predicting which patients will achieve pCR remains a challenge. CD10, a myoepithelial marker, has shown diagnostic and prognostic value in metastatic tumors. Its potential as a predictor of chemosensitivity to anthracycline-based NCT in breast
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Experimental models in Familial Mediterranean Fever (FMF): Insights into pathophysiology and therapeutic strategies Exp. Mol. Pathol. (IF 3.6) Pub Date : 2024-01-30 Nawal Mezher, Ola Mroweh, Louna Karam, José-Noel Ibrahim, Philippe Hussein Kobeissy
Familial Mediterranean Fever (FMF) is a recurrent polyserositis characterized by self-limiting episodes or attacks of fever along with serosal inflammation. It mainly impacts people of the Mediterranean and Middle Eastern basin. FMF is a recessive autoinflammatory condition caused by mutation in the MEFV gene located on chromosome 16p13. MEFV mutations lead to the activation of the pyrin inflammasome
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An in-silico analysis reveals further evidence of an aggressive subset of lung carcinoids sharing molecular features of high-grade neuroendocrine neoplasms Exp. Mol. Pathol. (IF 3.6) Pub Date : 2024-01-20 Giuseppe Pelosi, Valentina Melocchi, Elisa Dama, Paul Hofman, Marco De Luca, Adriana Albini, Maria Gemelli, Riccardo Ricotta, Mauro Papotti, Stefano La Rosa, Silvia Uccella, Sergio Harari, Angelica Sonzogni, Michael K. Asiedu, Dennis A. Wigle, Fabrizio Bianchi
Little is known as to whether there may be any pathogenetic link between pulmonary carcinoids and neuroendocrine carcinomas (NECs). A gene signature we previously found to cluster pulmonary carcinoids, large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC), and which encompassed MEN1, MYC, MYCL1, RICTOR, RB1, SDHA, SRC and TP53 mutations or copy number variations (CNVs), was
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Retraction notice to “Overexpression of cortistatin alleviates oxygen/glucose-deprivation-induced ER stress and prompts neural stem cell proliferation via SSTR2” [Experimental and Molecular Pathology 113 (2020) 104351] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-11-30 Xiulin Liang, Qing Mao, Donghong Huang, Jian Tang, Jinou Zheng
Abstract not available
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Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-11-18 Lulu Han, Shenghai Wang, Juan Li, Lulu Zhao, Hong Zhou
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The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon-β activation Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-11-03 Brian T. Reiss, Lissette Bouza, Swagath Thomas, Catherine D. Suarez, Erik R. Hill, Daniel Brian Nichols
Molluscum contagiosum virus (MCV) is a poxvirus that causes benign, persistent skin lesions. MCV encodes a variety of immune evasion molecules to dampen host immune responses. Two of these proteins are the MC159 and MC160 proteins. Both MC159 and MC160 contain two tandem death effector domains and share homology to the cellular FLIPs, FADD, and procaspase-8. MC159 and MC160 dampen several innate immune
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Corrigendum to “RAB5A effect on metastasis of hepatocellular carcinoma cell line via altering the pro-invasive content of exosomes” [Experimental and Molecular Pathology 120 (2021) 104632] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-11-03 Gilar Gorji-bahri, Hamid Reza Moghimi, Atieh Hashemi
Abstract not available
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SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-09-30 G. Cappelletti, E.V. Carsana, G. Lunghi, S. Breviario, C. Vanetti, A.B. Di Fonzo, E. Frattini, M. Magni, S. Zecchini, M. Clerici, M. Aureli, C. Fenizia
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Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-09-27 Lijiang Wang, Supaporn Kulthinee, John Slate-Romano, Thomas Zhao, Hamsa Shanmugam, Patrycja M Dubielecka, Ling X. Zhang, Gangjian Qin, Shougang Zhuang, Y. Eugene Chin, Ting C. Zhao
Introduction Irisin plays an important role in regulating tissue stress, cardiac function, and inflammation. Integrin αvβ5 was recently identified as a receptor for irisin to elicit its physiologic function. It remains unknown whether integrin αvβ5 is required for irisin's function in modulating the physiologic response to hemorrhage. The objective of this study is to examine if integrin αvβ5 contributes
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DNA methylation of HOX genes and its clinical implications in cancer Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-09-13 Xin Hu, Yong Wang, Xiaoyu Zhang, Chensheng Li, Xikun Zhang, Dongxia Yang, Yuanyuan Liu, Lianlian Li
Homeobox (HOX) genes encode highly conserved transcription factors that play vital roles in embryonic development. DNA methylation is a pivotal regulatory epigenetic signaling mark responsible for regulating gene expression. Abnormal DNA methylation is largely associated with the aberrant expression of HOX genes, which is implicated in a broad range of human diseases, including cancer. Numerous studies
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Effects of bisphenol A on murine salivary glands and human tumor cell lines Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-09-13 Gabriela Kelly da Silva, José Alcides Almeida de Arruda, Tatiana Fernandes Araújo Almeida, Sicília Rezende Oliveira, Paula Alves da Silva Rocha, Ricardo Alves Mesquita, Zenilda de Lourdes Cardeal, Helvécio Costa Menezes, Ivana Márcia Alves Diniz, Soraia Macari, Andréia Machado Leopoldino, Tarcília Aparecida Silva
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Characterization of human umbilical cord blood-derived mast cells using high-throughput expression profiling and next-generation knowledge discovery platforms Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-08-31 Sherin Bakhashab, Ghalya H. Banafea, Farid Ahmed, Haneen Alsehli, Huda F. AlShaibi, Nadia Bagatian, Ohoud Subhi, Kalamegam Gauthaman, Mahmood Rasool, Hans-Juergen Schulten, Peter Natesan Pushparaj
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A review of the critical role of vitamin D axis on the immune system Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-08-17 Gholamreza Daryabor, Nasser Gholijani, Fatemeh Rezaei Kahmini
In recent years, the physiological and molecular functions of vitamin D (Vit-D) have been deeply investigated. At first, Vit-D was considered a regulator of mineral and skeletal homeostasis. However, due to the extensive-expression pattern of Vit-D receptor (VDR) in almost every non-skeletal cell, Vit-D is considered mainly a multifunctional agent with broad effects on various tissues, notably the
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Epigenetic regulation of circ-HIPK3, circ-PVT1, miR-25, and miR-149 in radiosensitivity of breast cancer Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-08-09 Elahe Abdollahi, Hossein Mozdarani
Assessing the radiosensitivity of cells before administering radiation therapy (RT) to individuals diagnosed with breast cancer (BC) can facilitate the selection of appropriate treatment regimens and minimize the incidence of adverse side effects in patients undergoing radiation exposure. In this research, blood samples were obtained from 60 women who had been diagnosed with Invasive Ductal Carcinoma
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The biogenesis, biological functions and modification of Circular RNAs Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-05-13 Sen Liu, Xiang Yu Guo, Qing Juan Shang, Peng Gao
Circular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing
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Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-04-14 Paul Giacomo Bruch, Henning Plage, Sebastian Hofbauer, Kira Kornienko, Sarah Weinberger, Florian Roßner, Simon Schallenberg, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Steffen Hallmann, Stefan Koch, Nico Adamini, Sefer Elezkurtaj
Cytokeratin 20 (CK20) expression is limited to umbrella cells in the normal urothelium. Since CK20 is often upregulated in neoplastic urothelial cells including dysplasia and carcinoma in situ, immunohistochemical CK20 analysis is often used for the assessment of bladder biopsies. CK20 expression is a feature of luminal bladder cancer subtype, but its prognostic relevance is disputed. In this study
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Analysis of BRCA1 and BRCA2 alternative splicing in predisposition to ovarian cancer Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-03-03 Anna Jasiak, Magdalena Koczkowska, Maciej Stukan, Dariusz Wydra, Wojciech Biernat, Ewa Izycka-Swieszewska, Kamil Buczkowski, Michael R. Eccles, Logan Walker, Bartosz Wasag, Magdalena Ratajska
Background The mRNA splicing is regulated on multiple levels, resulting in the proper distribution of genes' transcripts in each cell and maintaining cell homeostasis. At the same time, the expression of alternative transcripts can change in response to underlying genetic variants, often missed during routine diagnostics. Aim The main aim of this study was to define the frequency of aberrant splicing
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Amplicon-based NGS test for assessing MLH1 promoter methylation and its correlation with BRAF mutation in colorectal cancer patients Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-02-07 Sara Iolanda Oliveira da Silva, Tabata Alves Domingos, Bruna Elisa Catin Kupper, Louise De Brot, Samuel Aguiar Junior, Dirce Maria Carraro, Giovana Tardin Torrezan
Detecting MLH1 promoter methylation is highly relevant to differentiate between possible Lynch syndrome patients or patients with sporadic causes of MLH1/PMS2 deficiency in colorectal (CRC) and endometrial cancers. Here, we aimed to develop a test for assessing MLH1 promoter methylation based in next generation sequencing (NGS), and to evaluate the concordance of MLH1 methylation and BRAF-V600 mutation
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Retraction notice to “ Probucol via inhibition of NHE1 attenuates LPS-accelerated atherosclerosis and promotes plaque stability in vivo” [Experimental and Molecular Pathology 96/2 (2014) 250–256] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-01-25 Li Jian-Fei, Chen Song, Feng Jun-Duo, Zhang Ming-Yu, Liu Xiao-Xia
Abstract not available
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Diversin upregulates the proliferative ability of colorectal cancer by inducing cell cycle proteins Exp. Mol. Pathol. (IF 3.6) Pub Date : 2023-01-07 Lan Luan, Nanyang Li, Keyuan Zhang, Xiaojie Wang, Hai Pan
Colorectal cancer (CRC) is a common gastrointestinal tumour with increasing incidence worldwide. However, the underlying molecular mechanism of CRC proliferation is not completely clear. Diversin,as an ankyrin repeat-containing protein, is upregulated in various solid tumours and accelerates cancer progression by promoting cell proliferation and increasing S phase fraction of cells. In this study,
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Docking is not enough: 17-trifluoromethylphenyl trinor PGF2α is only a very weak ligand of neurokinin-1 receptor Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-12-14 Joanna Matalińska, Piotr F.J. Lipiński
17-trifluoromethylphenyl trinor prostaglandin F2α (17-CF3PTPGF2α) was reported recently to exhibit in vitro and in vivo anticancer activity. Based solely on the results of in silico molecular docking, it was claimed that this compound is NK1 receptor (NK1R) antagonist and that its activity is through this receptor. In this contribution we show that 17-CF3PTPGF2α is only a very weak NK1R ligand (IC50 > 200 μM)
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Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-12-07 Elham Mohammadisoleimani, Zahra Firoozi, Mohammad Mehdi Naghizadeh, Ali Ghanbari Asad, Anahita Jafari, Mohammad Hosein Pourjafarian, Ali Ariafar, Hosein Mansoori, Hassan Dastsooz, Hani Sabaie, Shahryar Zeighami, Yaser Mansoori
Renal cell carcinoma (RCC) is a prevalent heterogeneous kidney cancer. So far, different genes have been reported for RCC development. However, its particular molecular mechanism remains unclear. Circular RNAs (circRNAs), a class of non-coding RNAs, are involved in numerous biological processes in different malignancies such as RCC. This study aims to assess the expression and underlying mechanism
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The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-11-24 Ahsas Goyal, Anant Agrawal, Aanchal Verma, Nandini Dubey
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. Numerous pathological processes including, inflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalance, and apoptosis as well as genetic factors may lead to neuronal degeneration. With the emergence of aging population, the health
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Corrigendum to “Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune Encephalomyelitis.” [Experimental and Molecular Pathology. 2014; 97(3):470–6. doi: 10.1016/j.yexmp.2014.10.004.] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-10-20 Nan Liu, Quan-cheng Kan, Xiao-jian Zhang, Yu-ming Xv, Su Zhang, Guang-Xian Zhang, Lin Zhu
Abstract not available
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Value of immunohistochemistry in crushed areas of pulmonary neuroendocrine carcinoma Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-10-04 Hava Kuçuk, David Laville, Pierre Dal-Col, Violaine Yvorel, Abdulrazzak Sulaiman, Sophie Bayle-Bleuez, Philippe Cosmo, Jean-Michel Vergnon, Olivier Tiffet, Anne-Laure Desage, Fabien Forest
Immunohistochemical demonstration of neuroendocrine differentiation is often performed in routine diagnostic practice for lung neuroendocrine carcinoma. However, these carcinomas are often crushed, especially on small specimens. The value of immunohistochemistry on crushed areas is not known. We aimed to assess the value of immunohistochemical markers in crushed areas. We performed a retrospective
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Increased synovial expression of calcitonin gene-related peptide and its potential roles in Charcot Neuroarthropathy Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-10-03 Yi Guo, Lew Schon, Sharada Paudel, Tyler Feltham, Lumanti Manandhar, Zijun Zhang
Objective Joint destruction in Charcot neuroarthropathy (CNA) is accompanied with abundant hyperplastic synovium. This study aimed to characterize the expression patterns of a group of neuropeptides in the CNA synovium. Methods Synovial specimens were collected during surgery from the CNA (n = 6) and non-CNA joints (n = 14). Tissue samples were processed for protein extraction and western blot for
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Targeted molecular profiling of epithelial ovarian cancer from Italian BRCA wild-type patients with a BRCA and PARP pathways gene panel Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-09-20 Annamaria Salvati, Ileana Carnevali, Elena Alexandrova, Sofia Facchi, Susanna Ronchi, Laura Libera, Nora Sahnane, Domenico Memoli, Jessica Lamberti, Sonia Amabile, Stefano Pepe, Roberta Tarallo, Fausto Sessa, Alessandro Weisz, Maria Grazia Tibiletti, Francesca Rizzo
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The impact of MCP1-2518A/G and CCR2-V64I genetic polymorphisms in Egyptian sickle cell disease patients Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-09-22 Nihal Salah Ibrahim, Manal Mohamed Makhlouf, Gehan Hamed Shahin, Mona Kamal Elghamrawy, Nehad Mohammed Hussein
Background Sickle cell disease (SCD) is an inherited genetic disorders of hemoglobin that causes multisystem morbidity. The pathophysiology of SCD is complex and includes HbS polymerization/sickling, hemolysis, endothelial dysfunction and inflammation. Chemokines are proteins playing an important role in the inflammation process and could be involved the context of pro-inflammatory SCD. Some chemokine
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A novel prognostic index of stomach adenocarcinoma based on immunogenomic landscape analysis and immunotherapy options Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-09-17 Weijie Xue, Bingzi Dong, Yixiu Wang, Yuwei Xie, Pu Li, Zhiqi Gong, Zhaojian Niu
Stomach adenocarcinoma (STAD) is one of the most common malignant tumors worldwide. In this study, we attempted to construct a valid immune-associated gene prognostic index risk model that can predict the survival of patients with STAD and the efficacy of immune checkpoint inhibitors (ICIs) treatment. Transcriptome, clinical, and gene mutational data were obtained from the TCGA database. Immune-related
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Microbial community profiling by next-generation DNA sequencing of adenocarcinoma of the prostate with evidence of ochratoxin A producing fungi Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-09-11 Stephen E. Fry, Mitchell Kaye, Dara S. Missan, Christian Becker, Matthew Shabilla, Delyn Martinez, Erin Bossert, Jeremy Ellis
Background Prostatic carcinomas are a leading cancer and leading cause of mortality in the developed world. The etiology is diverse with underlying patient genetics, environmental factors, and microbial associations. Sequencing DNA for microbes allows the detection of potential disease relationships. Objective Targeted 16S (prokaryotic) and 18S (eukaryotic) rDNA sequencing was performed to map the
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The importance of regulatory pathway mediated by Circ0001955 in colorectal cancer Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-29 Sepideh Kadkhoda, Soudeh Ghafouri-Fard, Farshid Noorbakhsh, Sima Ravaei, Farzaneh Darbeheshti, Mahsa M. Amoli, Reza Taslimi, Abbas Shakoori
Introduction Colorectal cancer (CRC) has become one of the most common cancers in recent years. Given the importance that non-coding RNAs have recently acquired in various diseases including cancers, we decided to design this study to evaluate the expression levels of circ0001955/miR-145-5p/ONECUT2 axis in CRC. Methods After bioinformatics analysis of GEO datasets related to CRC, a putative circ0001955/
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NK1 receptor antagonistic effect of 17-trifluoromethyl phenyl trinor prostaglandin F2α on the growth of human breast cancer cell line Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-25 Mutukuru Mayuri, Praveen T. Krishnamurthy, Thangavel Mahalingam Vijayakumar
Background A growing number of genetic and cancer biology investigations have found that the tachykinin NK1 Receptor plays an important role in cancer cell proliferation and survival. In this study. The present study was designed to evaluate the inhibition of cell growth by 17-trifluoromethyl phenyl trinor prostaglandin F2α with NK1 receptor in breast cancer cell lines. Materials and methods MDB-MB-468
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ST2 and the alteration of cobalt, sodium, potassium and calcium concentration in acute inflammation Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-28 Marija S. Stankovic, Silvio R. De Luka, Sasa Jankovic, Srdjan Stefanovic, Maja Stojanovic, Jelena Nesovic-Ostojic, Nina Japundzic-Zigon, Alexander M. Trbovich
Introduction ST2 is the receptor for interleukin (IL)-33, the last discovered member of the IL-1 cytokine family. Acute inflammation is an early response of vascularized tissue to injury, in which alteration of micro- and macro-elements occurs. This study aimed to examine the alteration of cobalt, sodium, potassium, and calcium concentration at the site of acute inflammation and the role of ST2 in
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Serum levels of matrix metalloproteinases as prognostic markers for severe dengue with plasma leakage Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-28 Srinivasan Sivasubramanian, Sundhar Mohandas, Vidya Gopalan, Karthikeyan Govindan, Poovazhagi Varadarajan, Krishnasamy Kaveri, Kunka Mohanram Ramkumar
Background Plasma leakage is a major pathogenic manifestation of severe dengue and is a precursor of life-threatening complications associated with dengue. Accumulating evidence indicates the role of Matrix Metalloproteinases (MMPs) in mediating vascular permeability and plasma leakage following induction by the dengue virus. This study aims to investigate the utility of MMP-2, MMP-3, and MMP-9 in
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Ranolazine alleviated cardiac/brain dysfunction in doxorubicin-treated rats Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-23 Titikorn Chunchai, Apiwan Arinno, Benjamin Ongnok, Patcharapong Pantiya, Thawatchai Khuanjing, Nanthip Prathumsap, Chayodom Maneechote, Nipon Chattipakorn, Siriporn C. Chattipakorn
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Phloretin enhances autophagy by impairing AKT activation and inducing JNK-Beclin-1 pathway activation Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-22 Chenghe Fan, Yilin Zhang, Yu Tian, Xinyu Zhao, Junfang Teng
Phloretin is a type of dihydrochalcone that is primarily found in apples and has been reported to possess various potent biological activities, such as anticancer, antioxidant and anti-inflammatory effects. Our previous study has shown that phloretin induces apoptosis in human glioblastoma. In this study, we found that phloretin induced autophagy in SH-SY5Y cells by decreasing p-AKT and p-mTOR levels
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MicroRNA-575 acts as a novel oncogene via targeting multiple signaling pathways in glioblastoma Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-25 Ashley Gray, Tiantian Cui, Erica Hlavin Bell, Joseph McElroy, Ebin Sebastian, Fuhai Li, Marjolein Geurts, Kevin Liu, Pierre Robe, S. Jaharul Haque, Arnab Chakravarti
Purpose Glioblastoma (GBM) patients currently face poor survival outcomes with an average survival period of <15 months, while only 3–5% of patients survive longer than 36 months. Although the mechanisms of tumorigenesis are still being elucidated, miRNAs are promising candidates to explore as novel and prognostic biomarkers in GBM. In this study, we identified the association between miR-575 expression
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Neurogranin regulates calcium-dependent cardiac hypertrophy Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-20 Ashton N. Jorgensen, Chowdhury S. Abdullah, Md. Shenuarin Bhuiyan, Megan Watt, Paari Dominic, Gopi K. Kolluru, Christopher G. Kevil, Hyung W. Nam
Intracellular Ca2+-calmodulin (CaM) signaling plays an important role in Ca2+-CaM-dependent kinase (CaMKII) and calcineurin (CaN)-mediated cardiac biology. While neurogranin (Ng) is known as a major Ca2+-CaM modulator in the brain, its pathophysiological role in cardiac hypertrophy has never been studied before. In the present study, we report that Ng is expressed in the heart and depletion of Ng dysregulates
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Retraction notice to “ Long non-coding RNA LINC00052 regulates miR-608/EGFR axis to promote progression of head and neck squamous cell carcinoma” [Experimental and Molecular Pathology 111 (2019) 104321] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-21 Tianbin Ouyang, Ying Zhang, Shixiong Tang, Yaowen Wang
Abstract not available
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Single nucleotide polymorphism patterns associated with a cancer resistant phenotype Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-21 June K. Dunnick, Arun R. Pandiri, Keith R. Shockley, Ronald Herbert, Deepak Mav, Dhiral Phadke, Ruchir R. Shah, B. Alex Merrick
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Single-cell transcriptomes identifies characteristic features of mouse macrophages in liver Mallory-Denk bodies formation Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-16 Rong Zhang, Bei Zhong, Jiashan He, Xinyu Yang, Menghua He, Wuyi Zeng, Jiayi Pan, Zixuan Fang, Jiangtao Jia, Hui Liu
Mallory-Denk bodies (MDBs) consist of intracellular aggregates of misfolded proteins in ballooned hepatocytes and serve as important markers of progression in certain liver diseases. Resident hepatic macrophage-mediated inflammation influences the development of chronic liver diseases and cancer. Here, the first systematic study of macrophages heterogeneity in mice was conducted to illustrate the pathogenesis
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Retraction notice to “ Geniposide suppresses growth, migration and invasion of MKN45 cells by down-regulation of lncRNA HULC” [Experimental and Molecular Pathology 105/3 (2018) 252–259] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-09 Ji Ma, Yong Ding
Abstract not available
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Retraction notice to “Lycium barbarum polysaccharides alleviate hydrogen peroxide-induced injury by up-regulation of miR-4295 in human trabecular meshwork cells” [Experimental and Molecular Pathology 106 (2019) 109–115] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-09 Yuxia Liu, Yan Zhang
Abstract not available
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Retraction notice to “Quercetin ameliorates lipopolysaccharide-caused inflammatory damage via down-regulation of miR-221 in WI-38 cells”: [Experimental and Molecular Pathology 108 (2019) 1–8] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-09 Chong Wang, Zhenghai Qu, Lingpeng Kong, Lei Xu, Mengxue Zhang, Jianke Liu, Zhaochuan Yang
Abstract not available
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Retraction notice to “ Baicalin protects human retinal pigment epithelial cell lines against high glucose-induced cell injury by up-regulation of microRNA-145” [Experimental and Molecular Pathology 106 (2019) 123–130] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-07 Chunhua Dai, Shanhao Jiang, Cuiying Chu, Meng Xin, Xiufen Song, Bojun Zhao
Abstract not available
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Retraction notice to "TRAF4 promotes endometrial cancer cell growth and migration by activation of PI3K/AKT/Oct4 signaling" [Experimental and Molecular Pathology 108 (2019) 9–16] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-06 Pengmu Xie, Xiuling Wang, Min Kong, Xiuyu Bai, Tao Jiang
Abstract not available
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Retraction notice to “ Triptolide inhibits viability and migration while promotes apoptosis in nephroblastoma cells by regulation of miR-193b-3p” [Experimental and Molecular Pathology 108 (2019) 80–88] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-05 Shiying Hang, Xianghong Wang, Hai Li
Abstract not available
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Retraction notice to “Anti-proliferation and anti-metastatic effects of sevoflurane on human osteosarcoma U2OS and Saos-2 cells” [Experimental and Molecular Pathology 108 (2019) 121–130] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-05 Ke Gao, Zhen Su, Hailin Liu, Yan Liu
Abstract not available
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Retraction notice to “Ligustrazine promoted hypoxia-treated cell growth by upregulation of miR-135b in human umbilical vein endothelial cells” [Experimental and Molecular Pathology 106 (2019) 102–108] Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-05 Shujing Wei, Hui Wang
Abstract not available
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Overexpression of SHARPIN promotes tumor progression in ovarian cancer Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-04 Guanghui Wang, Zi Zhuang, Jianxiang Cheng, Fan Yang, Dachun Zhu, Zhiyuan Jiang, Wensheng Du, Siyuan Shen, Ju Huang, Lei Hua, Youguo Chen
SHARPIN (Shank-associated RH domain interacting protein) plays an important role in tumorigenesis. However, its role in ovarian cancer remains largely unknown. To investigate this issue, we systematically analyzed the amplification and expression of the SHARPIN in the TCGA database. From the database, we found that SHARPIN was amplified in ovarian cancer compared to normal ovarian tissue, and the mRNA
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Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix Exp. Mol. Pathol. (IF 3.6) Pub Date : 2022-07-04 Laurie B. Joseph, Marion K. Gordon, Peihong Zhou, Rita A. Hahn, Hamdi Lababidi, Claire R. Croutch, Patrick J. Sinko, Diane E. Heck, Debra L. Laskin, Jeffrey D. Laskin
Sulfur mustard (SM; bis(2-chloroethyl) sulfide) is a highly reactive bifunctional alkylating agent synthesized for chemical warfare. The eyes are particularly sensitive to SM where it causes irritation, pain, photophobia, and blepharitis, depending on the dose and duration of exposure. In these studies, we examined the effects of SM vapor on the corneas of New Zealand white male rabbits. Edema and